The reaction of carbon-free oxide-based(corundum,spinel,zirconia,and mullite)submerged entry nozzle(SEN)lining with rare earth inclusions and its anti-clogging effects under near working conditions were systematically...The reaction of carbon-free oxide-based(corundum,spinel,zirconia,and mullite)submerged entry nozzle(SEN)lining with rare earth inclusions and its anti-clogging effects under near working conditions were systematically studied.A variety of lining composite test methods were innovatively used to ensure the consistency of test conditions.The experimental results showed that the mullite(acidic oxide)has strong reactivity with rare earth inclusions,and the spinel(basic oxide)has stable chemical properties and weak reactivity with rare earth inclusions.Because alumina is one of the main reactants of clogging formation,corundum is not suitable for SEN lining.There are less clogs on the surface of zirconia,but it will be exsoluted and unstable.Therefore,solving the problem of zirconia exsolution will greatly strengthen its application in SEN lining.展开更多
Non-metallic inclusions in steel are a significant challenge,affecting material properties and leading to issues such as stress concentration,cracking,and accelerated corrosion.Current methods for removing inclusions,...Non-metallic inclusions in steel are a significant challenge,affecting material properties and leading to issues such as stress concentration,cracking,and accelerated corrosion.Current methods for removing inclusions,including bubble,electromagnetic stirring,filtration separation,fluid flow,and sedimentation,often struggle with the removal of fine inclusions.Apart from these known methods,pulsed electric current(PEC),as an emerging technology,has demonstrated immense potential and environmental advantages.PEC offers adjustable current parameters and simple equipment,making it an attractive alternative to traditional methods.Its green energy-saving features and excellent results in regulating inclusion morphology and migration,as well as inhibiting submerged entry nozzle(SEN)clogging,make it a promising technology.In comparison to continuous current technology,PEC has shown significant advantages in regulating inclusions,not only improving purification efficiency but also demonstrating outstanding performance in flow stability and energy consumption.The ability of PEC to efficiently reduce inclusion numbers enhances the purity and quality of molten steel,improving its mechanical properties.Currently,the theoretical basis for controlling the movement of inclusions by current is mainly composed of three major theories:the double electric layer theory,electromagnetic force reverse separation theory,and electric free energy drive theory.These theories together form an important framework for researchers to understand and optimize the behavior of impurity movement controlled by electric current.Looking ahead,PEC is expected to pave the way for new solutions in directional regulation of inclusion migration,efficient inclusion removal,SEN clogging prevention,and the purification of molten steel.展开更多
Dear Editor,Lassa virus(LASV)is the causative agent of the acute viral hemorrhagic Lassa fever(LF),which is classified into Mammarenavirus within the Arenaviridae family,with a single-stranded,negative-sense,bisegment...Dear Editor,Lassa virus(LASV)is the causative agent of the acute viral hemorrhagic Lassa fever(LF),which is classified into Mammarenavirus within the Arenaviridae family,with a single-stranded,negative-sense,bisegmented RNA genome.Due to its high pathogenicity and lethality,LASV is considered as a priority threat to public health,with an estimated cases of 300,000 infections and 5000 deaths annually.LASV was first isolated and described as a clinical entity in 1969 in Lassa,Nigeria(Garry,2023).LASV isolates of different geographic and host origins are highly diverse in genomic sequences and phylogenetically classified into up to seven lineages,with each lineage predominately localized in specific countries.Although the research on LF has been carried out for decades since the pathogen first characterized,there is no approved antiviral drugs or vaccines for clinical use against LASV to date(Grant et al.,2023).One possible reason that hindered the development of countermeasures is that the preclinical studies on authentic LASV are restricted in high bio-containment biosafety level 4(BSL-4)facilities.In this letter,we describe isolation,and characterization of the LASV from the clinical samples.And we applied a coadministration assay of antiviral drugs for LASV by using a clinically isolated Mammarenavirus lassaense strain in the BSL-4 facility,aiming to investigate new therapeutic strategies for LASV infection.展开更多
Stromal interaction molecules(STIM)s are Ca^(2+)sensors in internal Ca^(2+)stores of the endoplasmic reticulum.They activate the store-operated Ca^(2+)channels,which are the main source of Ca^(2+)entry in non-excitabl...Stromal interaction molecules(STIM)s are Ca^(2+)sensors in internal Ca^(2+)stores of the endoplasmic reticulum.They activate the store-operated Ca^(2+)channels,which are the main source of Ca^(2+)entry in non-excitable cells.Moreover,STIM proteins interact with other Ca^(2+)channel subunits and active transporters,making STIMs an important intermediate molecule in orchestrating a wide variety of Ca^(2+)influxes into excitable cells.Nevertheless,little is known about the role of STIM proteins in brain functioning.Being involved in many signaling pathways,STIMs replenish internal Ca^(2+)stores in neurons and mediate synaptic transmission and neuronal excitability.Ca^(2+)dyshomeostasis is a signature of many pathological conditions of the brain,including neurodegenerative diseases,injuries,stroke,and epilepsy.STIMs play a role in these disturbances not only by supporting abnormal store-operated Ca^(2+)entry but also by regulating Ca^(2+)influx through other channels.Here,we review the present knowledge of STIMs in neurons and their involvement in brain pathology.展开更多
To enhance the recuperation rate of the mine and comply with the stipulations of green mining technology, it is vital to expeditiously recuperate the coal pillar resources in the final stage, thus preventing the consi...To enhance the recuperation rate of the mine and comply with the stipulations of green mining technology, it is vital to expeditiously recuperate the coal pillar resources in the final stage, thus preventing the considerable squandering of resources. The coal pillar resource of the main roadway and its branch roadway constitutes a significant recovery subject. Its coal pillar shape is regular and possesses a considerable strike distance, facilitating the arrangement of the coal pillar recovery working face (CPRWF) for mining operations. However, for the remaining coal pillars with a thick and hard roof (THF) and multiple tectonic zones, CPRWF encounters challenges in selecting an appropriate layout, managing excessive roof pressure, and predicting mining stress. Aiming at the roadway coal pillar group with THF and multi-structural areas in specific projects, a method of constructing multi-stage CPRWF by one side gob-side entry driving (GSED) and one side roadway reusing is proposed. Through theoretical calculation of roof fracture and numerical simulation verification, combined with field engineering experience and economic analysis, the width of the narrow coal pillar (NCP) in the GSED is determined to be 10 m and the length of the CPRWF is 65 m. Concurrently, the potential safety hazard that the roof will fall asymmetrically and THF is difficult to break during CPRWF mining after GSED is analyzed and verified. Then, a control method involving the pre-cutting of the roof in the reused roadway before mining is proposed. This method has been shown to facilitate the complete collapse of THF, reduce the degree of mine pressure, and facilitate the symmetrical breaking of the roof. Accordingly, a roof-cutting scheme based on a directional drilling rig, bidirectional shaped polyvinyl chloride (PVC) pipe, and emulsion explosive was devised, and the pre-splitting of 8.2 m THF was accomplished. Field observations indicate that directional cracks are evident in the roof, the coal wall is flat during CPRWF mining, and the overall level of mining pressure is within the control range. Therefore, the combined application of GSED and roof-cutting technology for coal pillar recovery has been successfully implemented, thereby providing new insights and engineering references for the construction and pressure relief mining of CPRWF.展开更多
Rapid and reliable onboard optimization of bank angle profiles is crucial for mitigating uncertainties during Mars atmospheric entry.This paper presents a neural-network-accelerated methodology for optimizing parametr...Rapid and reliable onboard optimization of bank angle profiles is crucial for mitigating uncertainties during Mars atmospheric entry.This paper presents a neural-network-accelerated methodology for optimizing parametric bank angle profiles in Mars atmospheric entry missions.The methodology includes a universal approach to handling path constraints and a reliable solution method based on the Particle Swarm Optimization(PSO)algorithm.For illustrative purposes,a mission with the objective of maximizing terminal altitude is considered.The original entry optimization problem is converted into optimizing three coefficients for the bank angle profiles with terminal constraints by formulating a parametric Mars entry bank angle profile and constraint handling methods.The parameter optimization problem is addressed using the PSO algorithm,with reliability enhanced by increasing the PSO swarm size.To improve computational efficiency,an enhanced Deep Operator Network(Deep ONet)is used as a dynamics solver to predict terminal states under various bank angle profiles rapidly.Numerical simulations demonstrate that the proposed methodology ensures reliable convergence with a sufficiently large PSO swarm while maintaining high computational efficiency facilitated by the neural-network-based dynamics solver.Compared to the existing methodologies,this methodology offers a streamlined process,the reduced sensitivity to initial guesses,and the improved computational efficiency.展开更多
Car manufacturers aim to enhance the use of two-factor authentication (2FA) to protect keyless entry systems in contemporary cars. Despite providing significant ease for users, keyless entry systems have become more s...Car manufacturers aim to enhance the use of two-factor authentication (2FA) to protect keyless entry systems in contemporary cars. Despite providing significant ease for users, keyless entry systems have become more susceptible to appealing attacks like relay attacks and critical fob hacking. These weaknesses present considerable security threats, resulting in unauthorized entry and car theft. The suggested approach combines a conventional keyless entry feature with an extra security measure. Implementing multi-factor authentication significantly improves the security of systems that allow keyless entry by reducing the likelihood of unauthorized access. Research shows that the benefits of using two-factor authentication, such as a substantial increase in security, far outweigh any minor drawbacks.展开更多
To evaluate the heat performance of the lifting-body entry vehicle during the hypersonic gliding phase,entry flight heat tests involving the determination of the maximum peak-heat-flux entry trajectory with complex co...To evaluate the heat performance of the lifting-body entry vehicle during the hypersonic gliding phase,entry flight heat tests involving the determination of the maximum peak-heat-flux entry trajectory with complex constraints are essential.A significant obstacle is the uncertainty of passage time or energy states of the maximum peak entry heat flux point and waypoints.This paper showcases an endeavour to leverage disjunctive programming and combinatorial theory for the max-max type(maximum peak-heat-flux)Entry Trajectory Optimization(ETO)problems with complex constraints such as dynamic pressure,normal load,waypoints,and no-fly zones.The concept of a"generalized waypoint"is introduced,and the maximum peak-heat-flux point is regarded as a"generalized waypoint".Through the application of propositional calculus rules,the derivation of generalized waypoints incorporating various physical quantities and magnitudes such as heat flux density,longitude,and latitude is actualized in one disjunctive normal form,enabling resolution via a unified method.Consequently,a novel method based on combinatorial prior rules is proposed,utilizing Successive Mixed-Integer Nonlinear Programming(SMINLP)to optimize various heat entry test flight trajectories.Numerical experiments are provided to show the computational accuracy,stability,and adaptability of the proposed method in solving maxmax type entry optimal control problems.展开更多
Gob-side entry retaining(GER)is widely applied in China.Nevertheless,the stability mechanism of the GER with coal pilla r-backfill body(CPBB)under dynamic overburden load remains unexplored.A voussoir beam structure(V...Gob-side entry retaining(GER)is widely applied in China.Nevertheless,the stability mechanism of the GER with coal pilla r-backfill body(CPBB)under dynamic overburden load remains unexplored.A voussoir beam structure(VBS)model is established to analyze roof structure stability during panel advancement,introducing a VBS stability criterion.Reducing block B length l and immediate roof damage variable D,and increasing coal pillar widthχ_(c).lowers the GER structure instability risk.Reducing l and the GER width w leads to a CPBB system stability upswing.A UDEC model was established to systematically reveal how the l,backfill body width x_(b),and strength affect the stability and coupling performance of the CPPB system by monitoring the crack damage D_(C).Simulation results indicate that at l=14 m,χ_(b)=2.0 m,watercement ratio 1.5:1,the coal pillar and backfill body have similar D_(C)but maintain stability,resulting in CPPB system coupling degree K,better.A novel GER method supported by the CPBB was implemented on-site.Monitoring results indicated that the coal pillar peak stresses were 19.17 MPa(ahead),16.14 MPa(behind),and the backfill body peak stress was 12.27 MPa(maximum).The floor heave was380 mm,with a 103 mm backfill body rib.展开更多
This paper reports an experimental investigation on the flow of a water entry cavity formed with a water jet cavitator.To investigate the formation characteristics,systematic water entry experiments were conducted in ...This paper reports an experimental investigation on the flow of a water entry cavity formed with a water jet cavitator.To investigate the formation characteristics,systematic water entry experiments were conducted in a water tank under different water jet rates,entry velocities,entry angles,and nozzle diameters.The formation mechanism of the water entry cavity was also analyzed.Results indicate that before the model impacts the water surface for water entry with a water jet cavitator,a gas bubble is created,and its width increases as the model approaches the water surface.Moreover,the length of the water jet gradually reduces to zero due to the increase in the static pressure of the water.The formation of the cavity is directly correlated with the location of the stagnation point moving downstream from the far field of the water jet to the exit of the water jet nozzle with the increasing entry depth.The dominant parameter is the momentum ratio of the water jet and quiescent water.展开更多
A non-pillar coal-mining technology with an automatically formed entry is proposed,which reduces the waste of coal resources and the underground entry drivage workload.Three key techniques in this technology cooperate...A non-pillar coal-mining technology with an automatically formed entry is proposed,which reduces the waste of coal resources and the underground entry drivage workload.Three key techniques in this technology cooperate to achieve automatic formation and retaining of the gob-side entry,and to realize nonpillar mining.Constant-resistance large deformation(CRLD)support ensures the stability of the entry roof;directional presplitting blasting(DPB)separates the entry roof and the gob roof;and a blockinggangue support system(BGSS)integrates the caved rock material as an effective entry rib.An industrial test was conducted to verify the engineering effects of these key techniques.The field application results showed that the retained entry was under the pressure-relief zone due to the broken-expansion nature of the caved rock mass within the DPB height.After going through a provisional dynamic pressure-bearing zone,the retained entry entered the stability zone.The final stable entry meets the requirements of safety and production.The research results demonstrate the good engineering applicability of this technology.By taking the framework of the technology design principles into consideration and adjusting the measures according to different site conditions,it is expected that the proposed non-pillar coal-mining technology can be popularized on a large scale.展开更多
Recent studies in secretory pathway calcium ATPases （SPCA） revealed novel functions of SPCA2 in interacting with store-operated Ca2＋ channel Oral I and inducing Ca2＋ influx at the cell surface. Importantly, SPCA2-...Recent studies in secretory pathway calcium ATPases （SPCA） revealed novel functions of SPCA2 in interacting with store-operated Ca2＋ channel Oral I and inducing Ca2＋ influx at the cell surface. Importantly, SPCA2-mediated Ca2＋ signaling is uncoupled from its conventional role of Ca2＋-ATPase and independent of store-operated Ca2＋ signaling pathway. SPCA2-induced store-independent Ca2＋ entry （SICE） plays essential roles in many important physiological processes, while unbalanced SICE leads to enhanced cell proliferation and tumorigenesis. Finally, we have summarized the clinical implication of SICE in oral cancer prognosis and treatment. Inhibition of SICE may be a new target for the development of cancer therapeutics.展开更多
Two different entry vehicles are presented here： the Inflatable Reentry and Descent Demonstrator （IRDT）, and Huygens. Both missions involve （re）entries at conditions close to orbital, and have been performed in 2...Two different entry vehicles are presented here： the Inflatable Reentry and Descent Demonstrator （IRDT）, and Huygens. Both missions involve （re）entries at conditions close to orbital, and have been performed in 2005. Specific aspects of the design and the mission of IRDT are briefly outlined. The preliminary results of the recent flight of IRDT and the methodology followed at ESTEC for the assessment of radiative fluxes for Huygens are summarised.展开更多
Retaining gob-side entryways and the stability of gas drainage boreholes are two essential techniques in the co-extraction of coal and gas without entry pillars （CECGWEP）. However, retained entryways located in deep...Retaining gob-side entryways and the stability of gas drainage boreholes are two essential techniques in the co-extraction of coal and gas without entry pillars （CECGWEP）. However, retained entryways located in deep coal mines are hard to maintain, especially for constructing boreholes in confined spaces, owing to major deformations. Consequently, it is difficult to drill boreholes and maintain their stability, which therefore cannot guarantee the effectiveness of gas drainage. This paper presents three measures for conducting CECGWEP in deep mines on the basis of effective space in retained entryways for gas drainage, They are combinations of retaining roadways and face-lagging inclined boreholes, retaining roadways and face-advancing inclined boreholes, and retaining roadways and high return airway inclined boreholes. Several essential techniques are suggested to improve the maintenance of retained entryways and the stabilization of boreholes. For the particular cases considered in this study, two field trials have verified the latter two measures from the results obtained from the faces 1111（1） and 11112（1） in the Zhuji Mine. The results indicate that these models can effectively solve the problems in deep mines. The maximum gas drainage flow for a single hole can reach 8.1 m^3/min and the effective drainage distance can be extended up to 150 m or more.展开更多
Hepatitis C virus (HCV) is a member of the Flaviviridae family and causes acute and chronic hepatitis. Chronic HCV infection may result in severe liver damage including liver cirrhosis and hepatocellular carcinoma. Th...Hepatitis C virus (HCV) is a member of the Flaviviridae family and causes acute and chronic hepatitis. Chronic HCV infection may result in severe liver damage including liver cirrhosis and hepatocellular carcinoma. The liver is the primary target organ of HCV, and the hepatocyte is its primary target cell. Attachment of the virus to the cell surface followed by viral entry is the first step in a cascade of interactions between the virus and the target cell that is required for successful entry into the cell and initiation of infection. This step is an important determinant of tissue tropism and pathogenesis; it thus represents a major target for antiviral host cell responses, such as antibody-mediated virus neutralization. Following the development of novel cell culture models for HCV infection our understanding of the HCV entry process and mechanisms of virus neutralization has been markedly advanced. In this review we summarize recent developments in the molecular biology of viral entry and its impact on pathogenesis of HCV infection, development of novel preventive and therapeutic antiviral strategies.展开更多
With the significant increase of the number of entry mails in China, mail inspection has become more and more challenge. Australia and New Zealand are the two countries recognized as the ones with the most stringent i...With the significant increase of the number of entry mails in China, mail inspection has become more and more challenge. Australia and New Zealand are the two countries recognized as the ones with the most stringent inspection and quarantine measures in the world. The mail inspection work in China, Australia and New Zealand was compared on the aspects of mail quarantine system, inspection, quarantine treatment and punishment, based on which something worth learning and referring could be found and some suggestions were put forward, with the aim to provide theoretical basis for the animal and plant quarantine of entry mails.展开更多
The literature suggests that protection of knowledge from the threat for opportunism is a primary mover for the choice of entry mode.However,the knowledge construct is oversimplified in the literature on entry mode.Th...The literature suggests that protection of knowledge from the threat for opportunism is a primary mover for the choice of entry mode.However,the knowledge construct is oversimplified in the literature on entry mode.The combination of different types of knowledge held by a firm reduces the risk of misappropriation and the threat of opportunism is often unimportant in entry mode decisions.Based on these discussions,a new conceptual knowledgebased model of entry mode choice is devoloped.In this model,the knowledge is classified into business knowledge and location knowledge,the strategies into exploitation and exploration.This model focuses on two main attributes of knowledge,namely,embedded ness and complementarity.It is suggested that embedded ness and complementarity of business knowledge and location knowledge affect the entry mode choice.The knowledge strategies moderate the relationships between the attributes of knowledge and entry mode.Transferring capacity is also introduced in this model.展开更多
The timing of river entry in the Atlantic salmon is known to depend on genetic, demographic and environmental factors, but little is known about the relative magnitude of among population and among year variation and ...The timing of river entry in the Atlantic salmon is known to depend on genetic, demographic and environmental factors, but little is known about the relative magnitude of among population and among year variation and covariation in this respect in natural state Atlantic salmon rives. To investigate this, variability in the timing of river entry in three historical Finnish Atlantic salmon populations were analyzed using salmon trap data collected during 1870- 1902. The analyses reveled that 1 ） the timing of river entry differed substantially and consistently among the rivers, and that 2） variation among the rivers was much larger than variation among years. Annual variations were not explained by regional environmental conditions, whereas in one river the timing of the local flood peak was a significant predictor of the timing of river entry. Differences in the timing of salmon entry to geographically closely situated rivers suggests that a regionally fixed opening date for coastal fisheries might not be the best management strategy as it may lead to uneven exploitation of salmon populations from different rivers [ Current Zoology 55 （5） ： 342 - 349, 2009] .展开更多
The process of low-velocity water entry is utilized on a large scale for the military and engineering purposes. However, there are rarely systematic experimental investigations into the low-velocity water entry of cyl...The process of low-velocity water entry is utilized on a large scale for the military and engineering purposes. However, there are rarely systematic experimental investigations into the low-velocity water entry of cylinder structure for reference. In order to obtain typical phenomena and relevant laws, we design a set of experimental facilities with adjustable parameters and better repeatability to study this process with a high-speed photography system. The influences of cylinder radius, initial velocity and entry angle on the process of lowvelocity water entry are tested. Results show that six typical phases exist in this process: structure submersion,necking, cavity formation, cavity abscission, spray at the free surface and jet formation. Three factors mentioned above are key parameters and influence the process in different degrees, and some laws obtained in this paper have a reasonable agreement with the theoretical results. Our results provide references for the relevant numerical researches and engineering applications.展开更多
In order to investigate the frequent occurrences of rock burst in gob-side entry during the mining process of the mining zone No. 7, the mechanical model of main roof of fully-mechanized caving mining before breaking ...In order to investigate the frequent occurrences of rock burst in gob-side entry during the mining process of the mining zone No. 7, the mechanical model of main roof of fully-mechanized caving mining before breaking was established by the Winkler foundation beam theory, and the stress evolution law of surrounding rock with different dip angles of the seam during the mining process was analyzed by using FLAC3 D. The results show that: with the dip angle changing from 45° to 0°, the solid-coal side of gobside entry begins to form an L-shaped stress concentration zone at a dip angle of 30°, and the stress concentration degree goes to higher and higher levels. However, the stress concentration degree of the coalpillar side goes to lower and lower levels; the influence range and peak stress of the abutment at the lateral strata of adjacent gob increase with dip angle decreasing and reach a maximum value at a dip angle of 0°, but the tailgate is not affected; the abutment pressure superposition of two adjacent gobs leads to stress concentration further enhancing in both sides of gob-side entry. With the influence of strong mining disturbance, rock burst is easily induced by dynamic and static combined load in the advanced segment of gob-side entry. To achieve stability control similar to that in the roadway, the key control strategy is to reinforce surrounding rock and unload both sides. Accordingly, the large-diameter drilling and high-pressure water injection combined unloading and reinforced support cooperative control technology was proposed and applied in field test. The results of Electromagnetic Emission(EME) and field observation showed that unloading and surrounding rock control effect was obvious.展开更多
基金supported by the National Outstanding Youth Science Fund Project of National Natural Science Foundation of China(52302031)National Natural Science Foundation of China(51932008 and 51772277)Central China Thousand Talents Project(204200510011).
文摘The reaction of carbon-free oxide-based(corundum,spinel,zirconia,and mullite)submerged entry nozzle(SEN)lining with rare earth inclusions and its anti-clogging effects under near working conditions were systematically studied.A variety of lining composite test methods were innovatively used to ensure the consistency of test conditions.The experimental results showed that the mullite(acidic oxide)has strong reactivity with rare earth inclusions,and the spinel(basic oxide)has stable chemical properties and weak reactivity with rare earth inclusions.Because alumina is one of the main reactants of clogging formation,corundum is not suitable for SEN lining.There are less clogs on the surface of zirconia,but it will be exsoluted and unstable.Therefore,solving the problem of zirconia exsolution will greatly strengthen its application in SEN lining.
基金supported by the Fundamental Research Funds for the Central Universities(No.FRF-BD-23-01).
文摘Non-metallic inclusions in steel are a significant challenge,affecting material properties and leading to issues such as stress concentration,cracking,and accelerated corrosion.Current methods for removing inclusions,including bubble,electromagnetic stirring,filtration separation,fluid flow,and sedimentation,often struggle with the removal of fine inclusions.Apart from these known methods,pulsed electric current(PEC),as an emerging technology,has demonstrated immense potential and environmental advantages.PEC offers adjustable current parameters and simple equipment,making it an attractive alternative to traditional methods.Its green energy-saving features and excellent results in regulating inclusion morphology and migration,as well as inhibiting submerged entry nozzle(SEN)clogging,make it a promising technology.In comparison to continuous current technology,PEC has shown significant advantages in regulating inclusions,not only improving purification efficiency but also demonstrating outstanding performance in flow stability and energy consumption.The ability of PEC to efficiently reduce inclusion numbers enhances the purity and quality of molten steel,improving its mechanical properties.Currently,the theoretical basis for controlling the movement of inclusions by current is mainly composed of three major theories:the double electric layer theory,electromagnetic force reverse separation theory,and electric free energy drive theory.These theories together form an important framework for researchers to understand and optimize the behavior of impurity movement controlled by electric current.Looking ahead,PEC is expected to pave the way for new solutions in directional regulation of inclusion migration,efficient inclusion removal,SEN clogging prevention,and the purification of molten steel.
基金supported by the National Key Research and Development Program of China(2022YFC2303300,2023YFC2605504)the National Natural Science Foundation of China(82172273 and 31670165)the Open Research Fund Program of the State Key Laboratory of Virology of China(2023JZZD-01).
文摘Dear Editor,Lassa virus(LASV)is the causative agent of the acute viral hemorrhagic Lassa fever(LF),which is classified into Mammarenavirus within the Arenaviridae family,with a single-stranded,negative-sense,bisegmented RNA genome.Due to its high pathogenicity and lethality,LASV is considered as a priority threat to public health,with an estimated cases of 300,000 infections and 5000 deaths annually.LASV was first isolated and described as a clinical entity in 1969 in Lassa,Nigeria(Garry,2023).LASV isolates of different geographic and host origins are highly diverse in genomic sequences and phylogenetically classified into up to seven lineages,with each lineage predominately localized in specific countries.Although the research on LF has been carried out for decades since the pathogen first characterized,there is no approved antiviral drugs or vaccines for clinical use against LASV to date(Grant et al.,2023).One possible reason that hindered the development of countermeasures is that the preclinical studies on authentic LASV are restricted in high bio-containment biosafety level 4(BSL-4)facilities.In this letter,we describe isolation,and characterization of the LASV from the clinical samples.And we applied a coadministration assay of antiviral drugs for LASV by using a clinically isolated Mammarenavirus lassaense strain in the BSL-4 facility,aiming to investigate new therapeutic strategies for LASV infection.
基金supported by grants from the Russian Science Foundation(23-44-00054)the National Natural Science Foundation of China(32261133525).
文摘Stromal interaction molecules(STIM)s are Ca^(2+)sensors in internal Ca^(2+)stores of the endoplasmic reticulum.They activate the store-operated Ca^(2+)channels,which are the main source of Ca^(2+)entry in non-excitable cells.Moreover,STIM proteins interact with other Ca^(2+)channel subunits and active transporters,making STIMs an important intermediate molecule in orchestrating a wide variety of Ca^(2+)influxes into excitable cells.Nevertheless,little is known about the role of STIM proteins in brain functioning.Being involved in many signaling pathways,STIMs replenish internal Ca^(2+)stores in neurons and mediate synaptic transmission and neuronal excitability.Ca^(2+)dyshomeostasis is a signature of many pathological conditions of the brain,including neurodegenerative diseases,injuries,stroke,and epilepsy.STIMs play a role in these disturbances not only by supporting abnormal store-operated Ca^(2+)entry but also by regulating Ca^(2+)influx through other channels.Here,we review the present knowledge of STIMs in neurons and their involvement in brain pathology.
基金Project(52204164) supported by the National Natural Science Foundation of ChinaProject(2023ZKPYSB01) supported by the Fundamental Research Funds for the Central Universities,China。
文摘To enhance the recuperation rate of the mine and comply with the stipulations of green mining technology, it is vital to expeditiously recuperate the coal pillar resources in the final stage, thus preventing the considerable squandering of resources. The coal pillar resource of the main roadway and its branch roadway constitutes a significant recovery subject. Its coal pillar shape is regular and possesses a considerable strike distance, facilitating the arrangement of the coal pillar recovery working face (CPRWF) for mining operations. However, for the remaining coal pillars with a thick and hard roof (THF) and multiple tectonic zones, CPRWF encounters challenges in selecting an appropriate layout, managing excessive roof pressure, and predicting mining stress. Aiming at the roadway coal pillar group with THF and multi-structural areas in specific projects, a method of constructing multi-stage CPRWF by one side gob-side entry driving (GSED) and one side roadway reusing is proposed. Through theoretical calculation of roof fracture and numerical simulation verification, combined with field engineering experience and economic analysis, the width of the narrow coal pillar (NCP) in the GSED is determined to be 10 m and the length of the CPRWF is 65 m. Concurrently, the potential safety hazard that the roof will fall asymmetrically and THF is difficult to break during CPRWF mining after GSED is analyzed and verified. Then, a control method involving the pre-cutting of the roof in the reused roadway before mining is proposed. This method has been shown to facilitate the complete collapse of THF, reduce the degree of mine pressure, and facilitate the symmetrical breaking of the roof. Accordingly, a roof-cutting scheme based on a directional drilling rig, bidirectional shaped polyvinyl chloride (PVC) pipe, and emulsion explosive was devised, and the pre-splitting of 8.2 m THF was accomplished. Field observations indicate that directional cracks are evident in the roof, the coal wall is flat during CPRWF mining, and the overall level of mining pressure is within the control range. Therefore, the combined application of GSED and roof-cutting technology for coal pillar recovery has been successfully implemented, thereby providing new insights and engineering references for the construction and pressure relief mining of CPRWF.
基金supported in part by the National Defense Basic Scientific Research Program of China(No.JCKY2021603B030)the Shenzhen Fundamental Research Program,China(No.JCYJ20220818102601004)the Science Center Program of National Natural Science Foundation of China(No.62188101)。
文摘Rapid and reliable onboard optimization of bank angle profiles is crucial for mitigating uncertainties during Mars atmospheric entry.This paper presents a neural-network-accelerated methodology for optimizing parametric bank angle profiles in Mars atmospheric entry missions.The methodology includes a universal approach to handling path constraints and a reliable solution method based on the Particle Swarm Optimization(PSO)algorithm.For illustrative purposes,a mission with the objective of maximizing terminal altitude is considered.The original entry optimization problem is converted into optimizing three coefficients for the bank angle profiles with terminal constraints by formulating a parametric Mars entry bank angle profile and constraint handling methods.The parameter optimization problem is addressed using the PSO algorithm,with reliability enhanced by increasing the PSO swarm size.To improve computational efficiency,an enhanced Deep Operator Network(Deep ONet)is used as a dynamics solver to predict terminal states under various bank angle profiles rapidly.Numerical simulations demonstrate that the proposed methodology ensures reliable convergence with a sufficiently large PSO swarm while maintaining high computational efficiency facilitated by the neural-network-based dynamics solver.Compared to the existing methodologies,this methodology offers a streamlined process,the reduced sensitivity to initial guesses,and the improved computational efficiency.
文摘Car manufacturers aim to enhance the use of two-factor authentication (2FA) to protect keyless entry systems in contemporary cars. Despite providing significant ease for users, keyless entry systems have become more susceptible to appealing attacks like relay attacks and critical fob hacking. These weaknesses present considerable security threats, resulting in unauthorized entry and car theft. The suggested approach combines a conventional keyless entry feature with an extra security measure. Implementing multi-factor authentication significantly improves the security of systems that allow keyless entry by reducing the likelihood of unauthorized access. Research shows that the benefits of using two-factor authentication, such as a substantial increase in security, far outweigh any minor drawbacks.
基金funded by the Key Laboratory of Cross-Domain Flight Interdisciplinary Technology,China(No.2024-KF02201)the National Natural Science Foundation of China(No.61973326)。
文摘To evaluate the heat performance of the lifting-body entry vehicle during the hypersonic gliding phase,entry flight heat tests involving the determination of the maximum peak-heat-flux entry trajectory with complex constraints are essential.A significant obstacle is the uncertainty of passage time or energy states of the maximum peak entry heat flux point and waypoints.This paper showcases an endeavour to leverage disjunctive programming and combinatorial theory for the max-max type(maximum peak-heat-flux)Entry Trajectory Optimization(ETO)problems with complex constraints such as dynamic pressure,normal load,waypoints,and no-fly zones.The concept of a"generalized waypoint"is introduced,and the maximum peak-heat-flux point is regarded as a"generalized waypoint".Through the application of propositional calculus rules,the derivation of generalized waypoints incorporating various physical quantities and magnitudes such as heat flux density,longitude,and latitude is actualized in one disjunctive normal form,enabling resolution via a unified method.Consequently,a novel method based on combinatorial prior rules is proposed,utilizing Successive Mixed-Integer Nonlinear Programming(SMINLP)to optimize various heat entry test flight trajectories.Numerical experiments are provided to show the computational accuracy,stability,and adaptability of the proposed method in solving maxmax type entry optimal control problems.
基金financial support provided by the National Natural Science Foundation of China(Nos.52574126and 52574144)the Xinjiang Uygur Autonomous Region Key R&D Project Task Special-Department and Department Linkage Project(No.2022B01051)+4 种基金the Major Project of Regional Joint Foundation of China(No.U21A20107)the Xinjiang Uygur Autonomous Region Tianchi Introduction Plan(No.2024XGYTCYC03)the Scientific Research Fund of Hunan Provincial Education Department(No.24A0359)the Urumqi City Hongshan Sci-Tech Innvoation Elite Talents Youth Top Talents Program(No.B241013004)the National Key Research and Development Program Young Scientists Project(No.2024YFC2910600)。
文摘Gob-side entry retaining(GER)is widely applied in China.Nevertheless,the stability mechanism of the GER with coal pilla r-backfill body(CPBB)under dynamic overburden load remains unexplored.A voussoir beam structure(VBS)model is established to analyze roof structure stability during panel advancement,introducing a VBS stability criterion.Reducing block B length l and immediate roof damage variable D,and increasing coal pillar widthχ_(c).lowers the GER structure instability risk.Reducing l and the GER width w leads to a CPBB system stability upswing.A UDEC model was established to systematically reveal how the l,backfill body width x_(b),and strength affect the stability and coupling performance of the CPPB system by monitoring the crack damage D_(C).Simulation results indicate that at l=14 m,χ_(b)=2.0 m,watercement ratio 1.5:1,the coal pillar and backfill body have similar D_(C)but maintain stability,resulting in CPPB system coupling degree K,better.A novel GER method supported by the CPBB was implemented on-site.Monitoring results indicated that the coal pillar peak stresses were 19.17 MPa(ahead),16.14 MPa(behind),and the backfill body peak stress was 12.27 MPa(maximum).The floor heave was380 mm,with a 103 mm backfill body rib.
基金Supported by the National Natural Science Foundation of China(No.52371344 and U22A2012)Guangdong Provincial Natural Science Foundation of China(No.2024A1515012274 and 2021A1515011917)+1 种基金The Fundamental Research Funds for the Central Universities,Sun Yat-sen University(No.22qntd0601)the start-up funding received by Prof.Yunhua Jiang from Sun Yat-sen University.
文摘This paper reports an experimental investigation on the flow of a water entry cavity formed with a water jet cavitator.To investigate the formation characteristics,systematic water entry experiments were conducted in a water tank under different water jet rates,entry velocities,entry angles,and nozzle diameters.The formation mechanism of the water entry cavity was also analyzed.Results indicate that before the model impacts the water surface for water entry with a water jet cavitator,a gas bubble is created,and its width increases as the model approaches the water surface.Moreover,the length of the water jet gradually reduces to zero due to the increase in the static pressure of the water.The formation of the cavity is directly correlated with the location of the stagnation point moving downstream from the far field of the water jet to the exit of the water jet nozzle with the increasing entry depth.The dominant parameter is the momentum ratio of the water jet and quiescent water.
基金This work was supported by the National Key Research and Development Program of China(2016YFC0600900)the Program of China Scholarship Council(201806430070).
文摘A non-pillar coal-mining technology with an automatically formed entry is proposed,which reduces the waste of coal resources and the underground entry drivage workload.Three key techniques in this technology cooperate to achieve automatic formation and retaining of the gob-side entry,and to realize nonpillar mining.Constant-resistance large deformation(CRLD)support ensures the stability of the entry roof;directional presplitting blasting(DPB)separates the entry roof and the gob roof;and a blockinggangue support system(BGSS)integrates the caved rock material as an effective entry rib.An industrial test was conducted to verify the engineering effects of these key techniques.The field application results showed that the retained entry was under the pressure-relief zone due to the broken-expansion nature of the caved rock mass within the DPB height.After going through a provisional dynamic pressure-bearing zone,the retained entry entered the stability zone.The final stable entry meets the requirements of safety and production.The research results demonstrate the good engineering applicability of this technology.By taking the framework of the technology design principles into consideration and adjusting the measures according to different site conditions,it is expected that the proposed non-pillar coal-mining technology can be popularized on a large scale.
基金supported by grant GM62142 from the National Institution of Health to Rajini RaoAmerican Heart Association Pre-doctoral Fellowship 0815058E to Ming-Ye Fengsupported by Open Fund of State Key Laboratory of Oral Diseases, Sichuan University
文摘Recent studies in secretory pathway calcium ATPases （SPCA） revealed novel functions of SPCA2 in interacting with store-operated Ca2＋ channel Oral I and inducing Ca2＋ influx at the cell surface. Importantly, SPCA2-mediated Ca2＋ signaling is uncoupled from its conventional role of Ca2＋-ATPase and independent of store-operated Ca2＋ signaling pathway. SPCA2-induced store-independent Ca2＋ entry （SICE） plays essential roles in many important physiological processes, while unbalanced SICE leads to enhanced cell proliferation and tumorigenesis. Finally, we have summarized the clinical implication of SICE in oral cancer prognosis and treatment. Inhibition of SICE may be a new target for the development of cancer therapeutics.
文摘Two different entry vehicles are presented here： the Inflatable Reentry and Descent Demonstrator （IRDT）, and Huygens. Both missions involve （re）entries at conditions close to orbital, and have been performed in 2005. Specific aspects of the design and the mission of IRDT are briefly outlined. The preliminary results of the recent flight of IRDT and the methodology followed at ESTEC for the assessment of radiative fluxes for Huygens are summarised.
基金Acknowledgments The research was supported by Program for Changjiang Scholars and Innovative Research Team in University （IRT_I4R55）, and the National Natural Science Foundation of China under Grant No. NSFC-51274193.
文摘Retaining gob-side entryways and the stability of gas drainage boreholes are two essential techniques in the co-extraction of coal and gas without entry pillars （CECGWEP）. However, retained entryways located in deep coal mines are hard to maintain, especially for constructing boreholes in confined spaces, owing to major deformations. Consequently, it is difficult to drill boreholes and maintain their stability, which therefore cannot guarantee the effectiveness of gas drainage. This paper presents three measures for conducting CECGWEP in deep mines on the basis of effective space in retained entryways for gas drainage, They are combinations of retaining roadways and face-lagging inclined boreholes, retaining roadways and face-advancing inclined boreholes, and retaining roadways and high return airway inclined boreholes. Several essential techniques are suggested to improve the maintenance of retained entryways and the stabilization of boreholes. For the particular cases considered in this study, two field trials have verified the latter two measures from the results obtained from the faces 1111（1） and 11112（1） in the Zhuji Mine. The results indicate that these models can effectively solve the problems in deep mines. The maximum gas drainage flow for a single hole can reach 8.1 m^3/min and the effective drainage distance can be extended up to 150 m or more.
文摘Hepatitis C virus (HCV) is a member of the Flaviviridae family and causes acute and chronic hepatitis. Chronic HCV infection may result in severe liver damage including liver cirrhosis and hepatocellular carcinoma. The liver is the primary target organ of HCV, and the hepatocyte is its primary target cell. Attachment of the virus to the cell surface followed by viral entry is the first step in a cascade of interactions between the virus and the target cell that is required for successful entry into the cell and initiation of infection. This step is an important determinant of tissue tropism and pathogenesis; it thus represents a major target for antiviral host cell responses, such as antibody-mediated virus neutralization. Following the development of novel cell culture models for HCV infection our understanding of the HCV entry process and mechanisms of virus neutralization has been markedly advanced. In this review we summarize recent developments in the molecular biology of viral entry and its impact on pathogenesis of HCV infection, development of novel preventive and therapeutic antiviral strategies.
文摘With the significant increase of the number of entry mails in China, mail inspection has become more and more challenge. Australia and New Zealand are the two countries recognized as the ones with the most stringent inspection and quarantine measures in the world. The mail inspection work in China, Australia and New Zealand was compared on the aspects of mail quarantine system, inspection, quarantine treatment and punishment, based on which something worth learning and referring could be found and some suggestions were put forward, with the aim to provide theoretical basis for the animal and plant quarantine of entry mails.
文摘The literature suggests that protection of knowledge from the threat for opportunism is a primary mover for the choice of entry mode.However,the knowledge construct is oversimplified in the literature on entry mode.The combination of different types of knowledge held by a firm reduces the risk of misappropriation and the threat of opportunism is often unimportant in entry mode decisions.Based on these discussions,a new conceptual knowledgebased model of entry mode choice is devoloped.In this model,the knowledge is classified into business knowledge and location knowledge,the strategies into exploitation and exploration.This model focuses on two main attributes of knowledge,namely,embedded ness and complementarity.It is suggested that embedded ness and complementarity of business knowledge and location knowledge affect the entry mode choice.The knowledge strategies moderate the relationships between the attributes of knowledge and entry mode.Transferring capacity is also introduced in this model.
基金supported by Academy of Finland and the University of Helsinki
文摘The timing of river entry in the Atlantic salmon is known to depend on genetic, demographic and environmental factors, but little is known about the relative magnitude of among population and among year variation and covariation in this respect in natural state Atlantic salmon rives. To investigate this, variability in the timing of river entry in three historical Finnish Atlantic salmon populations were analyzed using salmon trap data collected during 1870- 1902. The analyses reveled that 1 ） the timing of river entry differed substantially and consistently among the rivers, and that 2） variation among the rivers was much larger than variation among years. Annual variations were not explained by regional environmental conditions, whereas in one river the timing of the local flood peak was a significant predictor of the timing of river entry. Differences in the timing of salmon entry to geographically closely situated rivers suggests that a regionally fixed opening date for coastal fisheries might not be the best management strategy as it may lead to uneven exploitation of salmon populations from different rivers [ Current Zoology 55 （5） ： 342 - 349, 2009] .
基金the National Natural Science Foundation of China(No.11402143)the Shanghai Young University Teachers Training Scheme(No.A1-2035-14-0010-18)the Shanghai Ocean University Scientific Research Fund Projects(No.A2-0302-14-300067)
文摘The process of low-velocity water entry is utilized on a large scale for the military and engineering purposes. However, there are rarely systematic experimental investigations into the low-velocity water entry of cylinder structure for reference. In order to obtain typical phenomena and relevant laws, we design a set of experimental facilities with adjustable parameters and better repeatability to study this process with a high-speed photography system. The influences of cylinder radius, initial velocity and entry angle on the process of lowvelocity water entry are tested. Results show that six typical phases exist in this process: structure submersion,necking, cavity formation, cavity abscission, spray at the free surface and jet formation. Three factors mentioned above are key parameters and influence the process in different degrees, and some laws obtained in this paper have a reasonable agreement with the theoretical results. Our results provide references for the relevant numerical researches and engineering applications.
基金supported by the Key Project of National Natural Science Foundation of China (No.51634001)the National Natural Science Foundation of China (No.51404269 and 51674253)+1 种基金the State Key Research Development Program of China (No.2016YFC0801403)the Key Research Development Program of Jiangsu Province,China (No.BE2015040)
文摘In order to investigate the frequent occurrences of rock burst in gob-side entry during the mining process of the mining zone No. 7, the mechanical model of main roof of fully-mechanized caving mining before breaking was established by the Winkler foundation beam theory, and the stress evolution law of surrounding rock with different dip angles of the seam during the mining process was analyzed by using FLAC3 D. The results show that: with the dip angle changing from 45° to 0°, the solid-coal side of gobside entry begins to form an L-shaped stress concentration zone at a dip angle of 30°, and the stress concentration degree goes to higher and higher levels. However, the stress concentration degree of the coalpillar side goes to lower and lower levels; the influence range and peak stress of the abutment at the lateral strata of adjacent gob increase with dip angle decreasing and reach a maximum value at a dip angle of 0°, but the tailgate is not affected; the abutment pressure superposition of two adjacent gobs leads to stress concentration further enhancing in both sides of gob-side entry. With the influence of strong mining disturbance, rock burst is easily induced by dynamic and static combined load in the advanced segment of gob-side entry. To achieve stability control similar to that in the roadway, the key control strategy is to reinforce surrounding rock and unload both sides. Accordingly, the large-diameter drilling and high-pressure water injection combined unloading and reinforced support cooperative control technology was proposed and applied in field test. The results of Electromagnetic Emission(EME) and field observation showed that unloading and surrounding rock control effect was obvious.
