Several Trichoderma species serve as biocontrol agents in agriculture through their phytopathogen growth inhibition capabilities.However,the antagonistic mechanism of certain strains primarily operates through direct ...Several Trichoderma species serve as biocontrol agents in agriculture through their phytopathogen growth inhibition capabilities.However,the antagonistic mechanism of certain strains primarily operates through direct action.This study aims to explore an effective strain with comprehensive capabilities and elucidate its practical viability and action mechanism.Trichoderma gamsii strain TC959,exhibiting robust antagonistic and plant growth-promoting properties,was identified.The strain directly inhibits plant pathogen through the production of secondary metabolites,siderophores,and chitinase/xylanase,while promotes plant growth via indole-3-acetic acid/gibberellin release.Additionally,the strain activates induced systemic resistance by enhancing the chlorophyll a/b ratio and jasmonic acid content in pepper seedlings through root colonization,leading to elevated defense-related gene expression,antioxidant enzyme activity,and indole-3-acetic acid/gibberellin production.These mechanisms collectively enhance disease resistance and promote plant growth.Moreover,TC959 demonstrates superior resistance to oxidation and chemical fungicides,facilitating strain viability maintenance and ensuring healthy pepper seedling development.The study concludes that strain TC959 exhibits significant biocontrol potential and comprehensive functions against pepper damping-off disease,warranting further practical applications.展开更多
Due to the spatial characteristics of orbital angular momentum,vortex fields can be applied in the fields of quantum storage and quantum information.We study the realization of spatially modulated vortex fields based ...Due to the spatial characteristics of orbital angular momentum,vortex fields can be applied in the fields of quantum storage and quantum information.We study the realization of spatially modulated vortex fields based on four-wave mixing in a four-level atomic system with a diamond structure.The intensity and spiral phase of the vortex field are effectively transferred to the generated four-wave mixing field.By changing the detuning of the probe field,the phase and intensity of the generated vertex four-wave mixing field can be changed.When the probe field takes a large detuning value,the spatial distribution of the intensity and phase of the vertex four-wave mixing field can be effectively tuned by adjusting the Rabi frequency or detuning value of the coupled field.At the same time,we also provide a detailed explanation based on the dispersion relationship,and the results agree well with our simulation results.展开更多
Satellite-based atmospheric sounding measurements with high spectral resolution or from hyperspectral infrared （IR） sounders are important global observations for improving weather forecasts through assimilating the...Satellite-based atmospheric sounding measurements with high spectral resolution or from hyperspectral infrared （IR） sounders are important global observations for improving weather forecasts through assimilating them into operational numerical weather prediction （NWP） systems.展开更多
This paper aims at offering some suggestions for the college students who want to deliver an English speech.After the research,the author gives a brief description of the principles of language using in an English spe...This paper aims at offering some suggestions for the college students who want to deliver an English speech.After the research,the author gives a brief description of the principles of language using in an English speech.It goes from three aspects:choosing words effectively;using langusge strategically;building the speech reasonably.Thus,the author concludes that the success of an English speech will be made up of fully preparation of language usage,serious attitude and confidence.展开更多
The anti-corruption battle must go deeper,President Xi Jinping said on January 6,calling for strict governance of the Communist Party of China(CPC)systematically,creatively and effectively.Xi,also General Secretary of...The anti-corruption battle must go deeper,President Xi Jinping said on January 6,calling for strict governance of the Communist Party of China(CPC)systematically,creatively and effectively.Xi,also General Secretary of the CPC Central Committee and Chairman of the Central Military Commission。展开更多
King Gesar is an encyclopedia with contents covering social develop-ment, history, wars, religious belief, folklore, linguistics and exchanges between different tribes.In Tibet, folk balladeers declare they can sing u...King Gesar is an encyclopedia with contents covering social develop-ment, history, wars, religious belief, folklore, linguistics and exchanges between different tribes.In Tibet, folk balladeers declare they can sing up to 1,000 volumes of the epic, passed down through history orally and enriched in contents by the public themselves. The Central Government sets great store by the gathering, compiling and publishing of the epic, considered to be展开更多
Following is an interview by staff reporters of the Human Rights magazine with Zheng Silin, Chinese minister of labor and social security. The interview was meant in part to celebrate the tenth anniversary of the impl...Following is an interview by staff reporters of the Human Rights magazine with Zheng Silin, Chinese minister of labor and social security. The interview was meant in part to celebrate the tenth anniversary of the implementation of the Labor Law of the People's Republic of China that falls on January 1,2005. We are publishing this transcript with a view to providing our readers with information about how China has worked persistently to protect citizens' right to work and social security and the achievements it has made in this regard. We need to remind our readers of the fact that back in March 2004, the National People's Congress, China's highest legislature, approved a recommendation for revision of China's Constitution. In accordance with the recommendation, the Constitution had one more clause added: The state shall establish and improve a social security system commensurate to the level of the economic and social development.展开更多
To mitigate the massive volume expansion of Si-based anode during the charge/discharge cycles,we synthesized a superstructure of Si@Co±NC composite via the carbonization of zeolite imidazolate frameworks incorpor...To mitigate the massive volume expansion of Si-based anode during the charge/discharge cycles,we synthesized a superstructure of Si@Co±NC composite via the carbonization of zeolite imidazolate frameworks incorporated with Si nanoparticles.The Si@Co±NC is comprised of Sinanoparticle core and N-doped/Co-incorporated carbon shell,and there is void space between the core and the shell.When using as anode material for LIBs,Si@Co±NC displayed a super performance with a charge/discharge capacity of 191.6/191.4 mA h g^(-1)and a coulombic efficiency of 100.1%at 1000 mA g^(-1)after 3000 cycles,and the capacity loss rate is 0.022%per cycle only.The excellent electrochemical property of Si@Co±NC is because its electronic conductivity is enhanced by doping the carbon shell with N atoms and by incorporating with Co particles,and the pathway of lithium ions transmission is shortened by the hollow structure and abundant mesopores in the carbon shell.Also,the volume expansion of Si nanoparticles is well accommodated in the void space and suppressed by the carbon host matrix.This work shows that,through designing a superstructure for the anode materials,we can synergistically reduce the work function and introduce the confinement effect,thus significantly enhancing the anode materials’electrochemical performance in LIBs.展开更多
To overcome the serious technological issues affecting lithium-sulfur(Li-S) batteries,such as sluggish sulfur redox kinetics and the detrimental shuttle effect,heterostructure engineering has been investigated as a st...To overcome the serious technological issues affecting lithium-sulfur(Li-S) batteries,such as sluggish sulfur redox kinetics and the detrimental shuttle effect,heterostructure engineering has been investigated as a strategy to effectively capture soluble lithium polysulfide intermediates and promote their conversion reaction by integrating highly polar metal oxides with catalytically active metals sulfides.However,to fully exploit the outstanding properties of heterostructure-based composites,their detailed structure and interfacial contacts should be designed rationally.Herein,optimally arranged TiO_(2)and MoS_(2)-based heterostructures(TiO_(2)@MoS_(2)) are fabricated on carbon cloth as a multifunctional interlayer to efficiently trap polysulfide intermediates and accelerate their redox kinetics.Owing to the synergistic effects between TiO_(2)and MoS_(2)and the uniform heterointerface distribution that induces the ideally oriented built-in electric field,Li-S batteries with TiO_(2)@MoS_(2)interlayers exhibit high rate capability(601 mA h g^(-1)at 5 C),good cycling stability(capacity-fade rate of 0.067% per cycle over 500 cycles at2 C),and satisfactory areal capacity(5.2 mA h cm^(-2)) under an increased sulfur loading of 5.2 mg cm^(-2).Moreover,by comparing with a MoS_(2)@TiO_(2)interlayer composed of reversely arranged heterostructures,the effect of the built-in electric field’s direction on the electrocatalytic reactions of polysulfide intermediates is thoroughly investigated for the first time.The superior electrocatalytic activities of the rationally arranged TiO_(2)@MoS_(2)interlayer demonstrate the importance of optimizing the built-in electric field of heterostructures for producing high-performance Li-S batteries.展开更多
Micro Small Medium Enterprises (MSMEs) in Indonesia play huge part of national economic development because MSMEs can reduce unemployment rate. But, it is not easy to manage MSMEs well so it can be sustainable. There ...Micro Small Medium Enterprises (MSMEs) in Indonesia play huge part of national economic development because MSMEs can reduce unemployment rate. But, it is not easy to manage MSMEs well so it can be sustainable. There are some reasons why MSMEs are difficult to sustain, i.e., good management people by communicate effectively. Authors believe that one of important ability that owners, as a leader, must have in order to communicate effectively is cultural intelligence. Even in MSMEs, cultural intelligence plays important part because employees in MSMEs are diverse. They come from different region (mean having different tradition) and have different level of education. Methodology that is used in this article is qualitative method, and techniques of data collection are interview and observation. Technique of choosing informant is purposive and convenience while data analysis is using content analysis. The result of this study shows that leaders in MSMEs already have cultural intelligence to communicate with their employee. Leaders who have cultural intelligence can choose right method to communicate effectively with their employee.展开更多
There are many important factors to help learn English better.In learning English, vocabulary could be very important part because it is a fundamental element to form a sentence. So many English teachers try very hard...There are many important factors to help learn English better.In learning English, vocabulary could be very important part because it is a fundamental element to form a sentence. So many English teachers try very hard to use different and new ways to make their vocabulary teaching effective, and also improve students' ability of using the language. Here we are going to see what kinds of new ways an English teacher can use to help students to learn English vocabulary better.展开更多
As the beginning of school education, kindergarten plays an important role in guiding children to establish a correct outlook on life and values. With the development of the times, the status of traditional culture in...As the beginning of school education, kindergarten plays an important role in guiding children to establish a correct outlook on life and values. With the development of the times, the status of traditional culture in people's hearts is getting lower and lower. They often ignore the positive role of traditional culture in life. Therefore, the kindergarten to carry out traditional festival education activities is not only the educational content of early childhood education, but also the inevitable requirement of the development of the times. Based on the problems existing in the kindergarten's traditional festival education activities, this paper explores the effective ways to carry out the traditional festival education activities. The first is to set up a publicity corridor for students to learn traditional festivals in their daily study and life. The second is to strengthen the communication between the family and the school, and pay attention to the role of family education in the traditional festival education. The third is to strengthen teacher training, brainstorm and innovate the educational content and methods of traditional festival educational activities;The fourth is to attach importance to the connection between traditional festivals and modern life, so that students can feel the existence of traditional festivals in daily life.展开更多
Music performance major requires students to have rich experience in professional stage practice.Therefore,in the process of promoting the teaching of music performance,the effective connection between the teaching of...Music performance major requires students to have rich experience in professional stage practice.Therefore,in the process of promoting the teaching of music performance,the effective connection between the teaching of professional music performance skills and professional stage experience practice needs to be emphasized.With professional experience in teaching practice,this article analyzes the course teaching and stage practice of music performance,suggesting several problems in the current teaching methods,and from different angles,this article suggests countermeasures to effectively dock professional skills teaching with stage practice in hope to provide practical reference for relevant professionals so as to better cultivate and improve students’comprehensive application ability in music performance.展开更多
Learning, forgetting and learning again is the objective law of learning. In the primary school learning process, students' psychology is relatively simple, easy to forget in the process of learning, so math teach...Learning, forgetting and learning again is the objective law of learning. In the primary school learning process, students' psychology is relatively simple, easy to forget in the process of learning, so math teachers in primary school need to fully pay attention to the students' math review work. So that students can review the teaching content in time and often, students can effectively review before forgetting the knowledge points, students can effectively remember a large number of knowledge points in a short period of time. Based on the above perspective, the paper analyzes in detail how to review the primary school mathematics effectively, hoping to provide an effective reference for China's primary school mathematics teaching.展开更多
With the continuous development of China's economy, China's quality-oriented education and the new curriculum reform are gradually deepening, reflected in primary education, the cultivation of students' co...With the continuous development of China's economy, China's quality-oriented education and the new curriculum reform are gradually deepening, reflected in primary education, the cultivation of students' comprehensive quality has more and more attracted the attention of teachers and parents, which also puts forward more strict requirements for primary school head teachers, need to pay more attention to moral education. Generally speaking, in the process of implementing moral education, the head teacher in primary school will adopt incentive strategy, which is also a common teaching method. If the incentive strategy is applied in the management of primary school head teachers, it can not only arouse students' strong interest in learning moral education knowledge, but also mobilize students' initiative to participate in moral education activities, promote the continuous reform and improvement of moral education in primary schools, and cultivate students with good qualities and correct values. This paper analyzes and discusses how to carry out incentive strategies in the moral education of primary school head teachers.展开更多
Despite significant advances in targeted therapies and immunotherapies,non-small cell lung cancer(NSCLC)continues to present a global health challenge,with a modest five-year survival rate of 28%,largely due to the em...Despite significant advances in targeted therapies and immunotherapies,non-small cell lung cancer(NSCLC)continues to present a global health challenge,with a modest five-year survival rate of 28%,largely due to the emergence of treatment-resistant and metastatic tumors.In response,we synthesized a novel bioactive compound,ethyl 6-chlorocoumarin-3-carboxylyl L-theanine(TClC),which significantly inhibited NSCLC growth,epithelial mesenchymal transition(EMT),migration,and invasion in vitro and tumor growth and metastasis in vivo without inducing toxicity.TClC disrupts autocrine loops that promote tumor progression,particularly in stem-like CD133-positive NSCLC(CD133+LC)cells,which are pivotal in tumor metastasis.Through targeted molecular assays,we identified direct binding targets of TClC,including Akt,NF-κB,β-catenin,EZH2,and PD-L1.This interaction not only suppresses the expression of oncogenic factors and cancer stem cell markers but also downregulates the expression of a multidrug resistance transporter,underscoring the compound’s poly-pharmacological potential.These results position TClC as a promising candidate for NSCLC treatment,signaling a new era in the development of cancer therapies that directly target multiple critical cancer pathways.展开更多
Dear Editor,Rosacea is characterized by persistent or transient erythema,papules,pustules,telangiectasia,and/or phymatous lesions[1].Although multiple treatments are available for rosacea,the advent of biological agen...Dear Editor,Rosacea is characterized by persistent or transient erythema,papules,pustules,telangiectasia,and/or phymatous lesions[1].Although multiple treatments are available for rosacea,the advent of biological agents and small-molecule agents has significantly advanced our ability to target the disease more effectively[2].In the current review,we summarize the outcomes of targeted therapies in rosacea,mainly focusing on interleukin(IL)-17 inhibitors and Janus kinase(JAK)inhibitors.展开更多
Terahertz biotechnology has been increasingly applied in various biomedical fields and has especially shown great potential for application in brain sciences.In this article,we review the development of terahertz biot...Terahertz biotechnology has been increasingly applied in various biomedical fields and has especially shown great potential for application in brain sciences.In this article,we review the development of terahertz biotechnology and its applications in the field of neuropsychiatry.Available evidence indicates promising prospects for the use of terahertz spectroscopy and terahertz imaging techniques in the diagnosis of amyloid disease,cerebrovascular disease,glioma,psychiatric disease,traumatic brain injury,and myelin deficit.In vitro and animal experiments have also demonstrated the potential therapeutic value of terahertz technology in some neuropsychiatric diseases.Although the precise underlying mechanism of the interactions between terahertz electromagnetic waves and the biosystem is not yet fully understood,the research progress in this field shows great potential for biomedical noninvasive diagnostic and therapeutic applications.However,the biosafety of terahertz radiation requires further exploration regarding its two-sided efficacy in practical applications.This review demonstrates that terahertz biotechnology has the potential to be a promising method in the field of neuropsychiatry based on its unique advantages.展开更多
Ischemic stroke is a secondary cause of mortality worldwide,imposing considerable medical and economic burdens on society.Extracellular vesicles,serving as natural nanocarriers for drug delivery,exhibit excellent bioc...Ischemic stroke is a secondary cause of mortality worldwide,imposing considerable medical and economic burdens on society.Extracellular vesicles,serving as natural nanocarriers for drug delivery,exhibit excellent biocompatibility in vivo and have significant advantages in the management of ischemic stroke.However,the uncertain distribution and rapid clearance of extracellular vesicles impede their delivery efficiency.By utilizing membrane decoration or by encapsulating therapeutic cargo within extracellular vesicles,their delivery efficacy may be greatly improved.Furthermore,previous studies have indicated that microvesicles,a subset of large-sized extracellular vesicles,can transport mitochondria to neighboring cells,thereby aiding in the restoration of mitochondrial function post-ischemic stroke.Small extracellular vesicles have also demonstrated the capability to transfer mitochondrial components,such as proteins or deoxyribonucleic acid,or their sub-components,for extracellular vesicle-based ischemic stroke therapy.In this review,we undertake a comparative analysis of the isolation techniques employed for extracellular vesicles and present an overview of the current dominant extracellular vesicle modification methodologies.Given the complex facets of treating ischemic stroke,we also delineate various extracellular vesicle modification approaches which are suited to different facets of the treatment process.Moreover,given the burgeoning interest in mitochondrial delivery,we delved into the feasibility and existing research findings on the transportation of mitochondrial fractions or intact mitochondria through small extracellular vesicles and microvesicles to offer a fresh perspective on ischemic stroke therapy.展开更多
Bay-site carboxyl functionalized perylene diimide derivative 1,7-COOH-PDI-C_(12)(PDI-COOH)was synthesized and distinct enhanced fluorescence was observed through combining with calcium ion(Ca^(2+))in THF/H_(2)O soluti...Bay-site carboxyl functionalized perylene diimide derivative 1,7-COOH-PDI-C_(12)(PDI-COOH)was synthesized and distinct enhanced fluorescence was observed through combining with calcium ion(Ca^(2+))in THF/H_(2)O solution.The assembly and fluorescence behavior of PDI-COOH/Ca^(2+)were studied in detail by changing hydration state with different concentrations.Based on the differences in assembly morphology and stoichiometric ratios of PDICOOH/Ca^(2+),we proposed the fluorescence emission mechanism of PDI-COOH/Ca^(2+)in THF/H_(2)O and THF,respectively.This work reveals a novel strategy of aggregated state fluorescence enhancement and reminds us of the important role of water in molecular fluorescence emission and assembly.展开更多
基金supported by the National Key Research and Development Program of China(2022YFC2303000).
文摘Several Trichoderma species serve as biocontrol agents in agriculture through their phytopathogen growth inhibition capabilities.However,the antagonistic mechanism of certain strains primarily operates through direct action.This study aims to explore an effective strain with comprehensive capabilities and elucidate its practical viability and action mechanism.Trichoderma gamsii strain TC959,exhibiting robust antagonistic and plant growth-promoting properties,was identified.The strain directly inhibits plant pathogen through the production of secondary metabolites,siderophores,and chitinase/xylanase,while promotes plant growth via indole-3-acetic acid/gibberellin release.Additionally,the strain activates induced systemic resistance by enhancing the chlorophyll a/b ratio and jasmonic acid content in pepper seedlings through root colonization,leading to elevated defense-related gene expression,antioxidant enzyme activity,and indole-3-acetic acid/gibberellin production.These mechanisms collectively enhance disease resistance and promote plant growth.Moreover,TC959 demonstrates superior resistance to oxidation and chemical fungicides,facilitating strain viability maintenance and ensuring healthy pepper seedling development.The study concludes that strain TC959 exhibits significant biocontrol potential and comprehensive functions against pepper damping-off disease,warranting further practical applications.
基金Project supported by the National Natural Science Foundation of China (Grant Nos.11704151 and 11247201)the Twelfth Five-year Program for Science and Technology of Education Department of Jilin Province (Grant No.20150215)。
文摘Due to the spatial characteristics of orbital angular momentum,vortex fields can be applied in the fields of quantum storage and quantum information.We study the realization of spatially modulated vortex fields based on four-wave mixing in a four-level atomic system with a diamond structure.The intensity and spiral phase of the vortex field are effectively transferred to the generated four-wave mixing field.By changing the detuning of the probe field,the phase and intensity of the generated vertex four-wave mixing field can be changed.When the probe field takes a large detuning value,the spatial distribution of the intensity and phase of the vertex four-wave mixing field can be effectively tuned by adjusting the Rabi frequency or detuning value of the coupled field.At the same time,we also provide a detailed explanation based on the dispersion relationship,and the results agree well with our simulation results.
文摘Satellite-based atmospheric sounding measurements with high spectral resolution or from hyperspectral infrared （IR） sounders are important global observations for improving weather forecasts through assimilating them into operational numerical weather prediction （NWP） systems.
文摘This paper aims at offering some suggestions for the college students who want to deliver an English speech.After the research,the author gives a brief description of the principles of language using in an English speech.It goes from three aspects:choosing words effectively;using langusge strategically;building the speech reasonably.Thus,the author concludes that the success of an English speech will be made up of fully preparation of language usage,serious attitude and confidence.
文摘The anti-corruption battle must go deeper,President Xi Jinping said on January 6,calling for strict governance of the Communist Party of China(CPC)systematically,creatively and effectively.Xi,also General Secretary of the CPC Central Committee and Chairman of the Central Military Commission。
文摘King Gesar is an encyclopedia with contents covering social develop-ment, history, wars, religious belief, folklore, linguistics and exchanges between different tribes.In Tibet, folk balladeers declare they can sing up to 1,000 volumes of the epic, passed down through history orally and enriched in contents by the public themselves. The Central Government sets great store by the gathering, compiling and publishing of the epic, considered to be
文摘Following is an interview by staff reporters of the Human Rights magazine with Zheng Silin, Chinese minister of labor and social security. The interview was meant in part to celebrate the tenth anniversary of the implementation of the Labor Law of the People's Republic of China that falls on January 1,2005. We are publishing this transcript with a view to providing our readers with information about how China has worked persistently to protect citizens' right to work and social security and the achievements it has made in this regard. We need to remind our readers of the fact that back in March 2004, the National People's Congress, China's highest legislature, approved a recommendation for revision of China's Constitution. In accordance with the recommendation, the Constitution had one more clause added: The state shall establish and improve a social security system commensurate to the level of the economic and social development.
基金financial supports by the National Natural Science Foundation of China(No.51772295)support of GTIIT for the collaboration,and the start-up fund provided by GTIIT
文摘To mitigate the massive volume expansion of Si-based anode during the charge/discharge cycles,we synthesized a superstructure of Si@Co±NC composite via the carbonization of zeolite imidazolate frameworks incorporated with Si nanoparticles.The Si@Co±NC is comprised of Sinanoparticle core and N-doped/Co-incorporated carbon shell,and there is void space between the core and the shell.When using as anode material for LIBs,Si@Co±NC displayed a super performance with a charge/discharge capacity of 191.6/191.4 mA h g^(-1)and a coulombic efficiency of 100.1%at 1000 mA g^(-1)after 3000 cycles,and the capacity loss rate is 0.022%per cycle only.The excellent electrochemical property of Si@Co±NC is because its electronic conductivity is enhanced by doping the carbon shell with N atoms and by incorporating with Co particles,and the pathway of lithium ions transmission is shortened by the hollow structure and abundant mesopores in the carbon shell.Also,the volume expansion of Si nanoparticles is well accommodated in the void space and suppressed by the carbon host matrix.This work shows that,through designing a superstructure for the anode materials,we can synergistically reduce the work function and introduce the confinement effect,thus significantly enhancing the anode materials’electrochemical performance in LIBs.
基金supported by the National R&D Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science and ICT (2018M3D1A1058793 and 2021R1A3B1068920)supported by the Creative Materials Discovery Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science and ICT (2018M3D1A1058744)the Yonsei Signature Research Cluster Program of 2021 (2021-22-0002)。
文摘To overcome the serious technological issues affecting lithium-sulfur(Li-S) batteries,such as sluggish sulfur redox kinetics and the detrimental shuttle effect,heterostructure engineering has been investigated as a strategy to effectively capture soluble lithium polysulfide intermediates and promote their conversion reaction by integrating highly polar metal oxides with catalytically active metals sulfides.However,to fully exploit the outstanding properties of heterostructure-based composites,their detailed structure and interfacial contacts should be designed rationally.Herein,optimally arranged TiO_(2)and MoS_(2)-based heterostructures(TiO_(2)@MoS_(2)) are fabricated on carbon cloth as a multifunctional interlayer to efficiently trap polysulfide intermediates and accelerate their redox kinetics.Owing to the synergistic effects between TiO_(2)and MoS_(2)and the uniform heterointerface distribution that induces the ideally oriented built-in electric field,Li-S batteries with TiO_(2)@MoS_(2)interlayers exhibit high rate capability(601 mA h g^(-1)at 5 C),good cycling stability(capacity-fade rate of 0.067% per cycle over 500 cycles at2 C),and satisfactory areal capacity(5.2 mA h cm^(-2)) under an increased sulfur loading of 5.2 mg cm^(-2).Moreover,by comparing with a MoS_(2)@TiO_(2)interlayer composed of reversely arranged heterostructures,the effect of the built-in electric field’s direction on the electrocatalytic reactions of polysulfide intermediates is thoroughly investigated for the first time.The superior electrocatalytic activities of the rationally arranged TiO_(2)@MoS_(2)interlayer demonstrate the importance of optimizing the built-in electric field of heterostructures for producing high-performance Li-S batteries.
文摘Micro Small Medium Enterprises (MSMEs) in Indonesia play huge part of national economic development because MSMEs can reduce unemployment rate. But, it is not easy to manage MSMEs well so it can be sustainable. There are some reasons why MSMEs are difficult to sustain, i.e., good management people by communicate effectively. Authors believe that one of important ability that owners, as a leader, must have in order to communicate effectively is cultural intelligence. Even in MSMEs, cultural intelligence plays important part because employees in MSMEs are diverse. They come from different region (mean having different tradition) and have different level of education. Methodology that is used in this article is qualitative method, and techniques of data collection are interview and observation. Technique of choosing informant is purposive and convenience while data analysis is using content analysis. The result of this study shows that leaders in MSMEs already have cultural intelligence to communicate with their employee. Leaders who have cultural intelligence can choose right method to communicate effectively with their employee.
文摘There are many important factors to help learn English better.In learning English, vocabulary could be very important part because it is a fundamental element to form a sentence. So many English teachers try very hard to use different and new ways to make their vocabulary teaching effective, and also improve students' ability of using the language. Here we are going to see what kinds of new ways an English teacher can use to help students to learn English vocabulary better.
文摘As the beginning of school education, kindergarten plays an important role in guiding children to establish a correct outlook on life and values. With the development of the times, the status of traditional culture in people's hearts is getting lower and lower. They often ignore the positive role of traditional culture in life. Therefore, the kindergarten to carry out traditional festival education activities is not only the educational content of early childhood education, but also the inevitable requirement of the development of the times. Based on the problems existing in the kindergarten's traditional festival education activities, this paper explores the effective ways to carry out the traditional festival education activities. The first is to set up a publicity corridor for students to learn traditional festivals in their daily study and life. The second is to strengthen the communication between the family and the school, and pay attention to the role of family education in the traditional festival education. The third is to strengthen teacher training, brainstorm and innovate the educational content and methods of traditional festival educational activities;The fourth is to attach importance to the connection between traditional festivals and modern life, so that students can feel the existence of traditional festivals in daily life.
基金the Research on“Double Effect Teaching Practice”of Vocal Stage Art Practice Course(Number:2021JG63).
文摘Music performance major requires students to have rich experience in professional stage practice.Therefore,in the process of promoting the teaching of music performance,the effective connection between the teaching of professional music performance skills and professional stage experience practice needs to be emphasized.With professional experience in teaching practice,this article analyzes the course teaching and stage practice of music performance,suggesting several problems in the current teaching methods,and from different angles,this article suggests countermeasures to effectively dock professional skills teaching with stage practice in hope to provide practical reference for relevant professionals so as to better cultivate and improve students’comprehensive application ability in music performance.
文摘Learning, forgetting and learning again is the objective law of learning. In the primary school learning process, students' psychology is relatively simple, easy to forget in the process of learning, so math teachers in primary school need to fully pay attention to the students' math review work. So that students can review the teaching content in time and often, students can effectively review before forgetting the knowledge points, students can effectively remember a large number of knowledge points in a short period of time. Based on the above perspective, the paper analyzes in detail how to review the primary school mathematics effectively, hoping to provide an effective reference for China's primary school mathematics teaching.
文摘With the continuous development of China's economy, China's quality-oriented education and the new curriculum reform are gradually deepening, reflected in primary education, the cultivation of students' comprehensive quality has more and more attracted the attention of teachers and parents, which also puts forward more strict requirements for primary school head teachers, need to pay more attention to moral education. Generally speaking, in the process of implementing moral education, the head teacher in primary school will adopt incentive strategy, which is also a common teaching method. If the incentive strategy is applied in the management of primary school head teachers, it can not only arouse students' strong interest in learning moral education knowledge, but also mobilize students' initiative to participate in moral education activities, promote the continuous reform and improvement of moral education in primary schools, and cultivate students with good qualities and correct values. This paper analyzes and discusses how to carry out incentive strategies in the moral education of primary school head teachers.
基金supported by the National Key Research and Development Program of China(2017YFB0702600,2017YFB0702602,2017YFB0702602-2)the Shandong Provincial Natural Science Foundation(ZR2019MH076,ZR2022MH291)+3 种基金the Ministry of Science and Technology of the People’s Republic of China(“863 grant”,2012AA020206)the Department of Science and Technology of Shan-dong Province(20092009GG10002087)the National Natural Science Foundation of China(81603024,30973553)the NIH grant R01 CA186100,Wenzhou Institute University of Chinese Academy of Sciences,and Corbett Estate Fund for the Cancer Research(62285-531021-41800,62285-531021-51800,62285-531021-61800,62285-531021-71800).
文摘Despite significant advances in targeted therapies and immunotherapies,non-small cell lung cancer(NSCLC)continues to present a global health challenge,with a modest five-year survival rate of 28%,largely due to the emergence of treatment-resistant and metastatic tumors.In response,we synthesized a novel bioactive compound,ethyl 6-chlorocoumarin-3-carboxylyl L-theanine(TClC),which significantly inhibited NSCLC growth,epithelial mesenchymal transition(EMT),migration,and invasion in vitro and tumor growth and metastasis in vivo without inducing toxicity.TClC disrupts autocrine loops that promote tumor progression,particularly in stem-like CD133-positive NSCLC(CD133+LC)cells,which are pivotal in tumor metastasis.Through targeted molecular assays,we identified direct binding targets of TClC,including Akt,NF-κB,β-catenin,EZH2,and PD-L1.This interaction not only suppresses the expression of oncogenic factors and cancer stem cell markers but also downregulates the expression of a multidrug resistance transporter,underscoring the compound’s poly-pharmacological potential.These results position TClC as a promising candidate for NSCLC treatment,signaling a new era in the development of cancer therapies that directly target multiple critical cancer pathways.
文摘Dear Editor,Rosacea is characterized by persistent or transient erythema,papules,pustules,telangiectasia,and/or phymatous lesions[1].Although multiple treatments are available for rosacea,the advent of biological agents and small-molecule agents has significantly advanced our ability to target the disease more effectively[2].In the current review,we summarize the outcomes of targeted therapies in rosacea,mainly focusing on interleukin(IL)-17 inhibitors and Janus kinase(JAK)inhibitors.
基金supported by grants from the National Key R&D Program of China,No.2017YFC0909200(to DC)the National Natural Science Foundation of China,No.62075225(to HZ)+1 种基金Zhejiang Provincial Medical Health Science and Technology Project,No.2023XY053(to ZP)Zhejiang Provincial Traditional Chinese Medical Science and Technology Project,No.2023ZL703(to ZP).
文摘Terahertz biotechnology has been increasingly applied in various biomedical fields and has especially shown great potential for application in brain sciences.In this article,we review the development of terahertz biotechnology and its applications in the field of neuropsychiatry.Available evidence indicates promising prospects for the use of terahertz spectroscopy and terahertz imaging techniques in the diagnosis of amyloid disease,cerebrovascular disease,glioma,psychiatric disease,traumatic brain injury,and myelin deficit.In vitro and animal experiments have also demonstrated the potential therapeutic value of terahertz technology in some neuropsychiatric diseases.Although the precise underlying mechanism of the interactions between terahertz electromagnetic waves and the biosystem is not yet fully understood,the research progress in this field shows great potential for biomedical noninvasive diagnostic and therapeutic applications.However,the biosafety of terahertz radiation requires further exploration regarding its two-sided efficacy in practical applications.This review demonstrates that terahertz biotechnology has the potential to be a promising method in the field of neuropsychiatry based on its unique advantages.
基金supported by the grants from University of Macao,China,Nos.MYRG2022-00221-ICMS(to YZ)and MYRG-CRG2022-00011-ICMS(to RW)the Natural Science Foundation of Guangdong Province,No.2023A1515010034(to YZ)。
文摘Ischemic stroke is a secondary cause of mortality worldwide,imposing considerable medical and economic burdens on society.Extracellular vesicles,serving as natural nanocarriers for drug delivery,exhibit excellent biocompatibility in vivo and have significant advantages in the management of ischemic stroke.However,the uncertain distribution and rapid clearance of extracellular vesicles impede their delivery efficiency.By utilizing membrane decoration or by encapsulating therapeutic cargo within extracellular vesicles,their delivery efficacy may be greatly improved.Furthermore,previous studies have indicated that microvesicles,a subset of large-sized extracellular vesicles,can transport mitochondria to neighboring cells,thereby aiding in the restoration of mitochondrial function post-ischemic stroke.Small extracellular vesicles have also demonstrated the capability to transfer mitochondrial components,such as proteins or deoxyribonucleic acid,or their sub-components,for extracellular vesicle-based ischemic stroke therapy.In this review,we undertake a comparative analysis of the isolation techniques employed for extracellular vesicles and present an overview of the current dominant extracellular vesicle modification methodologies.Given the complex facets of treating ischemic stroke,we also delineate various extracellular vesicle modification approaches which are suited to different facets of the treatment process.Moreover,given the burgeoning interest in mitochondrial delivery,we delved into the feasibility and existing research findings on the transportation of mitochondrial fractions or intact mitochondria through small extracellular vesicles and microvesicles to offer a fresh perspective on ischemic stroke therapy.
文摘Bay-site carboxyl functionalized perylene diimide derivative 1,7-COOH-PDI-C_(12)(PDI-COOH)was synthesized and distinct enhanced fluorescence was observed through combining with calcium ion(Ca^(2+))in THF/H_(2)O solution.The assembly and fluorescence behavior of PDI-COOH/Ca^(2+)were studied in detail by changing hydration state with different concentrations.Based on the differences in assembly morphology and stoichiometric ratios of PDICOOH/Ca^(2+),we proposed the fluorescence emission mechanism of PDI-COOH/Ca^(2+)in THF/H_(2)O and THF,respectively.This work reveals a novel strategy of aggregated state fluorescence enhancement and reminds us of the important role of water in molecular fluorescence emission and assembly.
