Facing the body＇s EEG（electroencephalograph, 0.5–100 Hz, 5–100 μV） and ECG＇s（electrocardiogram,〈 100 Hz, 0.01–5 mV） micro signal detection requirement, this paper develops a pervasive application micro sign...Facing the body＇s EEG（electroencephalograph, 0.5–100 Hz, 5–100 μV） and ECG＇s（electrocardiogram,〈 100 Hz, 0.01–5 mV） micro signal detection requirement, this paper develops a pervasive application micro signal detection ASIC chip with the chopping modulation/demodulation method. The chopper-stabilization circuit with the RRL（ripple reduction loop） circuit is to suppress the ripple voltage, which locates at the single-stage amplifier＇s outputting terminal. The single-stage chopping core＇s noise has been suppressed too, and it is beneficial for suppressing noises of post-circuit. The chopping core circuit uses the PFB（positive feedback loop） to increase the inputting resistance, and the NFB（negative feedback loop） to stabilize the 40 dB intermediate frequency gain. The cascaded switch-capacitor sample/hold circuit has been used for deleting spike noises caused by non-ideal MOS switches, and the VGA/BPF（voltage gain amplifier/band pass filter） circuit is used to tune the chopper system＇s gain/bandwidth digitally. Assisted with the designed novel dry-electrode, the real test result of the chopping amplifying circuit gives some critical parameters： 8.1 μW/channel, 0.8 μVrms（@band-widthD100 Hz）, 4216–11220 times digitally tuning gain range, etc. The data capture system uses the NI CO＇s data capturing DAQmx interface,and the captured micro EEG/ECG＇s waves are real-time displayed with the PC-Labview. The proposed chopper system is a unified EEG/ECG signal＇s detection instrument and has a critical real application value.展开更多
目的:研究脑电(electroencephalogram,EEG)、心电(electrocardiogram,ECG)信号间的符号互信息(sign mutual information,SMI)和符号转移熵(sign transfer entropy,STE)在睡眠分期中的应用,为实现自动睡眠分期提供新思路。方法:使用9名...目的:研究脑电(electroencephalogram,EEG)、心电(electrocardiogram,ECG)信号间的符号互信息(sign mutual information,SMI)和符号转移熵(sign transfer entropy,STE)在睡眠分期中的应用,为实现自动睡眠分期提供新思路。方法:使用9名受试者整夜睡眠数据,以30 s同步EEG、ECG信号为一个样本,计算睡眠各时相EEG、ECG的SMI和STE。分析不同睡眠时相间SMI和STE值的差异性,并对睡眠各期的SMI和STE特征作统计学分析,验证分期效果。结果:每名受试者睡眠五期SMI、STE有明显的规律性,且各时相间STE值差异大多有显著统计学意义,分期效果更优于SMI。结论:SMI和STE两种特征可用于睡眠分期,且具有普遍性,为研究睡眠自动分期提供了重要思路。展开更多
In the present paper, effects of electroacupuncture (EA) of 3 points of the Heart Meridian and other 3 points of the Lung Meridian on changes of electrocardiogram (ECG), small intestinal electrogram (SIG) and electroe...In the present paper, effects of electroacupuncture (EA) of 3 points of the Heart Meridian and other 3 points of the Lung Meridian on changes of electrocardiogram (ECG), small intestinal electrogram (SIG) and electroencephalogram (EEG) in intravenous drip of pituitrin induced myocardial ischemia rabbits. The three points of the Heart Meridian are "Shenmen" (HT 7), "Lingdao" (HT 4) and one point between HT 7 and HT 4, the 3 points of the Lung Meridian are "Taiyuan"(LU 9), Lieque (LU 7) and one point between LU 9 and LU 7. These points are punctured with filiform needles and stimulated electrically by setting the parameters being frequency of 2.5 Hz, dense sparse waves and duration of 10 min. Results display that the regulative effect of EA of the Heart Meridian is superior to that of EA of the Lung Meridian on the three indexes, showing a closer correlation between the whole Heart Meridian and activities of ECG, SIG and EEG.展开更多
目前,心脑耦合算法的研究较少,研究方法主要为传统统计方法。提出一种基于改进Transformer模型新算法,通过该模型预测EEG到ECG的关系,并使用余弦相似度来评估预测准确率,实现耦合度分析。在DREAMER和Haaglanden Medisch Centrum Sleep S...目前,心脑耦合算法的研究较少,研究方法主要为传统统计方法。提出一种基于改进Transformer模型新算法,通过该模型预测EEG到ECG的关系,并使用余弦相似度来评估预测准确率,实现耦合度分析。在DREAMER和Haaglanden Medisch Centrum Sleep Staging Database数据集上分别对平静和睡眠状态下的数据进行训练。结果显示,平静状态下δ波与心电信号的耦合度最强(准确率86.12%),睡眠状态下β波与心电信号的耦合度最强(准确率96.70%)。该算法能够深度挖掘信号序列细节,直观展现心脑耦合程度,有助于心脑关系的研究。展开更多
基金Project supported by the National Natural Science Foundation of China(Nos.61527815,31500800,61501426,61471342)the National Key Basic Research Plan(No.2014CB744600)+1 种基金the Beijing Science and Technology Plan(No.Z141100000214002)the Chinese Academy of Sciences’Key Project(No.KJZD-EW-L11-2)
文摘Facing the body＇s EEG（electroencephalograph, 0.5–100 Hz, 5–100 μV） and ECG＇s（electrocardiogram,〈 100 Hz, 0.01–5 mV） micro signal detection requirement, this paper develops a pervasive application micro signal detection ASIC chip with the chopping modulation/demodulation method. The chopper-stabilization circuit with the RRL（ripple reduction loop） circuit is to suppress the ripple voltage, which locates at the single-stage amplifier＇s outputting terminal. The single-stage chopping core＇s noise has been suppressed too, and it is beneficial for suppressing noises of post-circuit. The chopping core circuit uses the PFB（positive feedback loop） to increase the inputting resistance, and the NFB（negative feedback loop） to stabilize the 40 dB intermediate frequency gain. The cascaded switch-capacitor sample/hold circuit has been used for deleting spike noises caused by non-ideal MOS switches, and the VGA/BPF（voltage gain amplifier/band pass filter） circuit is used to tune the chopper system＇s gain/bandwidth digitally. Assisted with the designed novel dry-electrode, the real test result of the chopping amplifying circuit gives some critical parameters： 8.1 μW/channel, 0.8 μVrms（@band-widthD100 Hz）, 4216–11220 times digitally tuning gain range, etc. The data capture system uses the NI CO＇s data capturing DAQmx interface,and the captured micro EEG/ECG＇s waves are real-time displayed with the PC-Labview. The proposed chopper system is a unified EEG/ECG signal＇s detection instrument and has a critical real application value.
文摘In the present paper, effects of electroacupuncture (EA) of 3 points of the Heart Meridian and other 3 points of the Lung Meridian on changes of electrocardiogram (ECG), small intestinal electrogram (SIG) and electroencephalogram (EEG) in intravenous drip of pituitrin induced myocardial ischemia rabbits. The three points of the Heart Meridian are "Shenmen" (HT 7), "Lingdao" (HT 4) and one point between HT 7 and HT 4, the 3 points of the Lung Meridian are "Taiyuan"(LU 9), Lieque (LU 7) and one point between LU 9 and LU 7. These points are punctured with filiform needles and stimulated electrically by setting the parameters being frequency of 2.5 Hz, dense sparse waves and duration of 10 min. Results display that the regulative effect of EA of the Heart Meridian is superior to that of EA of the Lung Meridian on the three indexes, showing a closer correlation between the whole Heart Meridian and activities of ECG, SIG and EEG.
