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Review on the pharmacological mechanisms and novel drug delivery system of vitexin
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作者 Jinghui Yang Mengyuan Zhao +2 位作者 Hongyue Wang Xinnan Li Xiangrong Zhang 《Journal of Polyphenols》 2024年第4期133-140,共8页
Vitexin is a natural phytofl avonoid glycoside extracted from the leaves of vitexin,a plant of the Verbenaceae family,which is an active ingredient in many traditional Chinese medicines and is present in a wide range ... Vitexin is a natural phytofl avonoid glycoside extracted from the leaves of vitexin,a plant of the Verbenaceae family,which is an active ingredient in many traditional Chinese medicines and is present in a wide range of medicinal plants.In this review,pharmacological eff ects including anti-infl ammatory,diabetes mellitus are described.The novel formulation of vitexin of nano delivery and hybrid micelles are elucidated. 展开更多
关键词 VITEXIN pharmacological eff ect BIOAVAILABILITY
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欧洲和北美学分积累与转换系统的比较研究--以欧洲ECTS与加拿大不列颠哥伦比亚省BCTS为例 被引量:16
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作者 孔磊 殷双绪 《远程教育杂志》 CSSCI 2012年第3期44-51,共8页
学分积累和转换是实现学生自由流动、促进社会成员终身学习的重要途径。目前,世界范围内很多国家和地区都已经建立了较为成熟的学分积累和转换系统,这其中以欧洲和北美地区最为出色。研究者采用比较研究的方法,对欧洲和北美地区比较有... 学分积累和转换是实现学生自由流动、促进社会成员终身学习的重要途径。目前,世界范围内很多国家和地区都已经建立了较为成熟的学分积累和转换系统,这其中以欧洲和北美地区最为出色。研究者采用比较研究的方法,对欧洲和北美地区比较有代表性的学分积累和转换系统——欧洲的ECTS和加拿大不列颠哥伦比亚省的BCTS,进行了对比分析,希望通过对比二者的异同,为我国正在开展的学分银行建设提供借鉴。比较分析发现,欧洲和北美的学分积累和转换系统建立的目的都是为了实现学习成果互认、促进高等教育资源共享,促进终身学习,但在学分积累和转换的具体策略、应用范围、应用效果等方面存在差异。欧洲通过制定一般性的准则、采用一些有利于学习结果透明化的工具,来为学分的积累和转换提供支持;而北美采用了社区学院和大学之间签订课程认证协议的方式,这种方式更为明确具体。欧洲的学分积累和转换系统在应用范围上更为广泛,但北美的学分转换系统在应用效果上优于对方。 展开更多
关键词 学分积累 学分转换 ects BCTS 比较研究
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我国高等教育学分转换与累积制度的ECTS借鉴 被引量:4
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作者 王玲 《教育与职业》 北大核心 2015年第21期16-20,共5页
从欧洲学分转换与累积制度的视角审视我国高等教育的学分转换与累积制度,需要解决五个问题:高等教育学分转换与累积制度建设理念与目标、我国高等教育学分体系、不同教育教学质量大学之间的学分转换与累积、不同教育类型之间的学分转换... 从欧洲学分转换与累积制度的视角审视我国高等教育的学分转换与累积制度,需要解决五个问题:高等教育学分转换与累积制度建设理念与目标、我国高等教育学分体系、不同教育教学质量大学之间的学分转换与累积、不同教育类型之间的学分转换与累积,以及该制度的实施策略与服务保障问题。 展开更多
关键词 高等教育学分转换 累积 ects
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曲妥珠单抗联合ECT化疗方案应用乳腺癌患者中对其血清肿瘤标志物的影响及治疗效果 被引量:1
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作者 代广全 王显臣 刘剑峰 《中国医药指南》 2025年第7期63-66,共4页
目的 探讨乳腺癌患者应用曲妥珠单抗联合ECT化疗方案对血清肿瘤标志物的影响及疗效。方法 选取2020年4月至2024年4月在青岛大学附属威海市立第二医院治疗的60例乳腺癌患者作为研究对象,按随机数字表法分组。对照组30例,给予ECT[表柔比星... 目的 探讨乳腺癌患者应用曲妥珠单抗联合ECT化疗方案对血清肿瘤标志物的影响及疗效。方法 选取2020年4月至2024年4月在青岛大学附属威海市立第二医院治疗的60例乳腺癌患者作为研究对象,按随机数字表法分组。对照组30例,给予ECT[表柔比星(E)+环磷酰胺(C)+紫杉醇(T)]化疗方案治疗;观察组30例,采取曲妥珠单抗联合ECT靶向治疗。观察两组的血清肿瘤标志物指标、血清炎症因子、近期疗效及远期疗效、不良反应的具体变化。结果 观察组糖类抗原125、癌胚抗原、糖类抗原153水平均低于对照组(均P <0.05);观察组炎症因子指标水平均低于对照组(均P <0.05);缓解率及2年生存率更高,复发率低于对照组(P <0.05);两组不良反应发生率差异无统计学意义(P> 0.05)。结论 曲妥珠单抗联合ECT化疗方案可有效减轻肿瘤负荷,增强抗肿瘤免疫反应,抑制炎症反应,延长患者生存周期并提高生存质量,降低复发风险。 展开更多
关键词 乳腺癌 曲妥珠单抗 ECT化疗方案 肿瘤标志物 远期疗效
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Nonlinear mixed-effects height to crown base and crown length dynamic models using the branch mortality technique for a Korean larch( Larix olgensis ) plantations in northeast China 被引量:8
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作者 Weiwei Jia Dongsheng Chen 《Journal of Forestry Research》 SCIE CAS CSCD 2019年第6期2095-2109,共15页
Korean larch(Larix olgensis)is one of the main tree species for aff orestation and timber production in northeast China.However,its timber quality and growth ability are largely infl uenced by crown size,structure and... Korean larch(Larix olgensis)is one of the main tree species for aff orestation and timber production in northeast China.However,its timber quality and growth ability are largely infl uenced by crown size,structure and shape.The majority of crown models are static models based on tree size and stand characteristics from temporary sample plots,but crown dynamic models has seldom been constructed.Therefore,this study aimed to develop height to crown base(HCB)and crown length(CL)dynamic models using the branch mortality technique for a Korean larch plantation.The nonlinear mixed-eff ects model with random eff ects,variance functions and correlation structures,was used to build HCB and CL dynamic models.The data were obtained from 95 sample trees of 19 plots in Meng JiaGang forest farm in Northeast China.The results showed that HCB progressively increases as tree age,tree height growth(HT growth)and diameter at breast height growth(DBH growth).The CL was increased with tree age in 20 years ago,and subsequently stabilized.HT growth,DBH growth stand basal area(BAS)and crown competition factor(CCF)signifi cantly infl uenced HCB and CL.The HCB was positively correlated with BAS,HT growth and DBH growth,but negatively correlated with CCF.The CL was positively correlated with BAS and CCF,but negatively correlated with DBH growth.Model fi tting and validation confi rmed that the mixed-eff ects model considering the stand and tree level random eff ects was accurate and reliable for predicting the HCB and CL dynamics.However,the models involving adding variance functions and time series correlation structure could not completely remove heterogeneity and autocorrelation,and the fi tting precision of the models was reduced.Therefore,from the point of view of application,we should take care to avoid setting up over-complex models.The HCB and CL dynamic models in our study may also be incorporated into stand growth and yield model systems in China. 展开更多
关键词 Larix olgensis plantation Height to CROWN BASE CROWN LENGTH Branch MORTALITY technique NONLINEAR mixed-eff ects models
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A high-resolution small animal SPECT system developed at Tsinghua 被引量:3
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作者 DAI Tiantian MATianyu +4 位作者 LIU Hui CUI Junjian WEI Qingyang LIU Yaqiang WANG Shi 《Nuclear Science and Techniques》 SCIE CAS CSCD 2011年第6期344-348,共5页
An SPECT system dedicated to small animal imaging shall be of a millimeter spatial resolution or even better.This study was aimed at achieving 0.5-mm spatial resolution for a small animal SPECT system at low cost.It w... An SPECT system dedicated to small animal imaging shall be of a millimeter spatial resolution or even better.This study was aimed at achieving 0.5-mm spatial resolution for a small animal SPECT system at low cost.It was developed from a single-head clinical SPECT scanner,with a seven-pinhole collimator and a four-degree-offreedom motion control stage.Several key techniques were developed,including high-resolution image reconstruction algorithm,high accuracy geometrical calibration method,and optimized system matrix derivation scheme.The system matrix was derived from Monte-Carlo simulation and de-noised by fitting each point spread function to a two dimensional Gaussian function.Experiments of point source and ultra micro hot rod phantom were conducted.With a spatial resolution of 0.5-0.6 mm,this system provides a practical way for low-cost high-resolution animal imaging on a clinic SPECT system. 展开更多
关键词 高分辨率图像重建 ECT系统 小动物 SP 清华大学 开发 空间分辨率 高斯函数拟合
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Single and combined eff ects of fertilization,ectomycorrhizal inoculation,and drought on container-grown Japanese larch seedlings 被引量:1
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作者 Evgenios Agathokleous Mitsutoshi Kitao +3 位作者 Masabumi Komatsu Yutaka Tamai Hisanori Harayama Takayoshi Koike 《Journal of Forestry Research》 SCIE CAS CSCD 2023年第4期1077-1094,共18页
Climate change can intensify drought in many regions of the world and lead to more frequent drought events or altered cycles of soil water status.Therefore,it is important to enhance the tolerance to drought and thus ... Climate change can intensify drought in many regions of the world and lead to more frequent drought events or altered cycles of soil water status.Therefore,it is important to enhance the tolerance to drought and thus health,vigor,and success of transplantation seedlings used in the forestry by modifying fertilization and promoting mycorrhization.Here,we sowed seeds of Japanese larch(Larix kaempferi)in 0.2-L containers with 0.5 g(low fertilization;LF)or 2 g(high fertilization;HF)of slow-release fertilizer early in the growing season.One month later,we irrigated seedlings with non-sterilized ectomycorrhizal inoculum(ECM)or sterilized solution(non-ECM),and after about 2 months,plants were either kept well watered(WW;500 mL water/plant/week)or subjected to drought(DR;50 mL water per plant/week)until the end of the growing season.HF largely stimulated plant growth and above-and belowground biomass production,eff ects that are of practical signifi cance,but caused a small decrease in stomatal conductance(Gs 390)and transpiration rate(E 390),which in practice is insignifi cant.ECM treatment resulted in moderate inhibition of seedling growth and biomass and largely canceled out the enhancement of biomass and foliar K content by HF.DR caused a large decrease in CO 2 assimilation,and enhanced stomatal closure and induced senescence.DR also largely depleted foliar Mg and enriched foliar K.Although DR caused a large decrease in foliar P content in LF,it moderately increased P in HF.Likewise,DR increased foliar K in HF but not in LF,and decreased foliar P in ECM plants but not in non-ECM plants.Conversely,ECM plants exhibited a large enrichment in foliar P under WW and had a lower water potential under DR when grown in LF.These results indicate that the drought tolerance and health and vigor of Japanese larch seedlings can be modifi ed by soil fertility and soil microorganisms.This study provides a basis for new multifactorial research programs aimed at producing seedlings of superior quality for forestation under climate change. 展开更多
关键词 DROUGHT ECTOMYCORRHIZAE Fertilizer eff ect Oxidative stress Stressor interactions
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Spectra of seismic force reduction factors of MDOF systems normalized by two characteristic periods 被引量:1
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作者 Li Xiao Tong Genshu Zhang Lei 《Earthquake Engineering and Engineering Vibration》 SCIE EI CSCD 2020年第1期53-69,共17页
Seismic force reduction factor(SFRF) spectra of shear-type multi-degree-of-freedom(MDOF) structures are investigated. The modified Clough model, capable of considering the strength-degradation/hardening and stiffnessd... Seismic force reduction factor(SFRF) spectra of shear-type multi-degree-of-freedom(MDOF) structures are investigated. The modified Clough model, capable of considering the strength-degradation/hardening and stiffnessdegradation, is adopted. The SFRF mean spectra using 102 earthquake records on a typical site soil type(type C) are constructed with the period abscissa being divided into three period ranges to maintain the peak features at the two sitespecific characteristic periods. Based on a large number of results, it is found that the peak value of SFRF spectra may also exist for MDOF, induced by large high-mode contributions to elastic base shear, besides the mentioned two peak values. The variations of the stiffness ratio λk and the strength ratio λF of the top to bottom story are both considered. It is found that the SFRFs for λF ≤λk are smaller than those for λF > λk. A SFRF modification factor for MDOF systems is proposed with respect to SDOF. It is found that this factor is significantly affected by the story number and ductility. With a specific λF(= λk0.75), SFRF mean spectra are constructed and simple solutions are presented for MDOF systems. For frames satisfying the strong column/weak beam requirement, an approximate treatment in the MDOF shear-beam model is to assign a post-limit stiffness 15%-35% of the initial stiffness to the hysteretic curve. SFRF spectra for MDOF systems with 0.2 and 0.3 times the post-limit stiffness are remarkably larger than those without post-limit stiffness. Thus, the findings that frames with beam hinges have smaller ductility demand are explained through the large post-limit stiffness. 展开更多
关键词 seismic force reduction factor multi-degree of freedom modifi ed Clough model characteristic period highmode eff ect post-limit stiff ness analysis
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Effects of site productivity on individual tree maximum basal area growth rates of Eucalyptus pilularis in subtropical Australia
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作者 P.W.West 《Journal of Forestry Research》 SCIE CAS CSCD 2023年第6期1659-1668,共10页
Inventory data were available from 96 plots of even-aged,monoculture,tall-open forests of Eucalyptus pilularis Smith,aged 2-63 years,growing in sub-tropical regions along the east coast of Australia.A model was develo... Inventory data were available from 96 plots of even-aged,monoculture,tall-open forests of Eucalyptus pilularis Smith,aged 2-63 years,growing in sub-tropical regions along the east coast of Australia.A model was developed relating the maximum possible stem basal area growth rate of individual trees to their stem basal area.For any tree size,this maximum increased as site productivity increased.However,the size at which this maximum occurred decreased as productivity increased.Much research has shown that,at any stand age,trees of a particular stem basal area are taller on more productive sites than on less productive ones.Taller trees incur greater respiratory costs to ensure maintenance of the photo synthetic capacity of their canopies;this reduces their growth rates.It was concluded that trees with larger basal areas will have the maximum possible growth rate on a less productive site,whilst trees with smaller basal areas will have the maximum possible on a more productive site.The model developed may constitute the first stage of a complete individual tree growth model system to predict wood yields from these forests. 展开更多
关键词 Growth model Individual tree Maximum growth rate Eucalyptus pilularis Physiological eff ects
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Sensor monitoring and online measurement correction in electric capacitance tomography system
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作者 张惠良 荣冈 《化工学报》 EI CAS CSCD 北大核心 2005年第4期664-667,共4页
The recalibration of electrical capacitance tomography (ECT) system is one of the key problems in keeping the system running steadily.However, for engineering application in solids/gas transport,online calibration can... The recalibration of electrical capacitance tomography (ECT) system is one of the key problems in keeping the system running steadily.However, for engineering application in solids/gas transport,online calibration can not be implemented and the data from this sensor may be unreliable due to the sensor pipe interior wall abrasion during pneumatic transport,so the solids concentration calculated from the reconstructed image based on these data will be highly inaccurate.The simulations show that, the inter-electrode relative capacitance variation of electrode pair spacing 1 is the most sensitive to the abrasion of sensor pipe interior wall, so this relative capacitance variation when the sensor is filled with air can be used as an indicator demanding offline system recalibration when the wall abrasion goes significant.Furthermore, while the pipe interior wall abrasion is not very serious, online correcting measured inter-electrode capacitance with wall capacitance variation can improve the accuracy of concentration calculation. 展开更多
关键词 传感器 在线测量技术 ECT系统 流体 电极 电容层析成像系统
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Optical fiber-based power and data delivery system for high voltage electronic current transformer
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作者 邱红辉 段雄英 邹积岩 《Journal of Shanghai University(English Edition)》 CAS 2008年第3期268-273,共6页
This paper describes a prototype power delivery system developed for high voltage electronic current transformer (ECT) that uses laser light to transfer power to and communicates with the primary converter. The desi... This paper describes a prototype power delivery system developed for high voltage electronic current transformer (ECT) that uses laser light to transfer power to and communicates with the primary converter. The design is based on optical-to-electrical power converters, solid-state diode lasers and optical fibers. Command signals are transmitted via the same up-fiber used to send power from secondary power supply to primary converter. The upward data transmission is completed during the brief interruption of power delivery without affecting steady power-supply. A simple comparator added to the primary converter can take the command data. Experimental results show that the fibers can provide reliable up-link for data transmission at 200 kb/s from the secondary to the primary converter. Based on the delivery system, the secondary converter can control three auxiliary channels to provide additional information. These monitoring channels are used in a time-multiplexing mode to provide information about the operation temperature, voltage and current at the remote unit for monitoring the ECT. This preventive maintenance or built-in test can increase reliability by giving early warning for necessary maintenance request. 展开更多
关键词 high voltage electronic current transformer (ECT) optical power supply delivery system photovoltaic powerconverters supervisory functions
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Research on the evaluation and mechanism of socio-economic benefit of highway projects
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作者 Wang Yuning Yun Yingxia Fan Zhiqing 《Engineering Sciences》 EI 2013年第6期91-96,共6页
Based on the theory of system dynamics, the paper analyzes the mechanism of socio-economic benefits of highway projects and establishes the system dynamics model of regional economic-highway development. Then taking J... Based on the theory of system dynamics, the paper analyzes the mechanism of socio-economic benefits of highway projects and establishes the system dynamics model of regional economic-highway development. Then taking Jinji(Tianjin--Jixian) Highway of Tianjin as an example, the errors of system simulation are tested, and the system dynamics model built is verified to be quite stable, which has a high performance. Through the comparison of simulation results with and without Jinji Highway, the paper simulates and predicts the socio-economie benefit of each year from 2003 to 2013. Thus the quantification evaluation of socio-economic benefit of highway project is realized and will provide the theory instructions for similar projects in the future. 展开更多
关键词 highway proj ect socio-economic benefit EVALUATION system dynamics
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基于PCNN图像融合的ECT多相流测量系统设计 被引量:1
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作者 李利品 李垄 +2 位作者 盛哲 白耀文 胡跃鑫 《仪表技术与传感器》 CSCD 北大核心 2024年第4期48-52,58,共6页
针对ECT在多相流测量过程中存在的成像质量不高、精度低、稳定性差等问题,提出并实现了基于PCNN图像融合的ECT多相流测量系统。系统采用模块化设计,主要包括阵列电极传感器模块、电容采集电路模块、上位机成像软件模块。文中设计改进的... 针对ECT在多相流测量过程中存在的成像质量不高、精度低、稳定性差等问题,提出并实现了基于PCNN图像融合的ECT多相流测量系统。系统采用模块化设计,主要包括阵列电极传感器模块、电容采集电路模块、上位机成像软件模块。文中设计改进的网络模型,将Tikhonov和Landweber算法的成像结果作为输入进行双通道融合成像,改善了传统算法存在的伪影、模糊的现象。实验结果表明:应用尼龙棒模拟气固两相流对系统进行测试,系统对于微小电容的测量具有良好的稳定性和准确性,通过系统的成像结果可以准确地分辨管道内不同介质的位置,其中对于流型的预测成功率为100%,相含率的测量误差在1%以内。 展开更多
关键词 ECT 多相流测量 图像融合 图像重建
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The ECT System for RAON'S Cavities
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作者 Mijoung Joung Yoochul Jung Hyungjin Kim 《Journal of Mechanics Engineering and Automation》 2015年第1期53-57,共5页
The ECT (eddy current test) system is in use for Nb surface quality control in many laboratories. This system can inspect Nb surthce quickly using high resolution probe. The ECT system for RAON's cavity was made wi... The ECT (eddy current test) system is in use for Nb surface quality control in many laboratories. This system can inspect Nb surthce quickly using high resolution probe. The ECT system for RAON's cavity was made with these features: it has a 3-axis acting probe movenlent system, it can inspect a big size of Nb sheet, which is 1,200 mm × 365 mm and it contains the analysis program that can show the result as a 2D and 3D images as well as the relative figure of the surface level. The standard sample was made with various sizes of defects using the same Nb sheet that was used to make RISP (Rare Isotope Science Project) cavity. The ECT system conditioning was carried out to optimize the ECT operation on the frequency of which the range is from 300 KHZ to 2 MHz. The result of 900 KHZ showed the strongest signal. The conditioning experiment on other parameter will be carried out in the near future. 展开更多
关键词 SRF (superconducting radio frequency) cavity eddy current NON-DESTRUCTIVE NIOBIUM ECT system
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miR-223-3p与ECT2表达在食管鳞状细胞癌组织中的相关性及与其预后的关系 被引量:1
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作者 范俊利 雷彩鹏 +1 位作者 张卫国 赵安顺 《实用癌症杂志》 2024年第6期898-903,924,共7页
目的探讨miR-223-3p与ECT2表达在食管鳞状细胞癌中的相关性及与其预后的关系。方法纳入85例食管鳞状细胞癌的石蜡包埋食管鳞状细胞癌组织、相应的正常食管黏膜组织。实时荧光定量PCR检测miR-223-3p与ECT2 mRNA水平,Pearson相关系数分析m... 目的探讨miR-223-3p与ECT2表达在食管鳞状细胞癌中的相关性及与其预后的关系。方法纳入85例食管鳞状细胞癌的石蜡包埋食管鳞状细胞癌组织、相应的正常食管黏膜组织。实时荧光定量PCR检测miR-223-3p与ECT2 mRNA水平,Pearson相关系数分析miR-223-3p与ECT2 mRNA表达水平的相关性。Kaplan-Meier生存分析和Cox比例风险模型分析miR-223-3p、ECT2表达对食管鳞状细胞癌预后的影响。结果ECT2高表达食管鳞状细胞癌患者46例,ECT2低表达食管鳞状细胞癌患者39例。ECT2 mRNA表达水平食管鳞状细胞癌组织高于正常食管黏膜组织,miR-223-3p表达水平食管鳞状细胞癌组织低于正常食管黏膜组织。ECT2表达水平与肿瘤大小、分化程度、TNM分期、血管侵犯相关。miR-223-3p表达水平与肿瘤大小、分化程度、TNM分期、血管侵犯相关。此外,食管鳞状细胞癌中miR-223-3p与ECT2 mRNA表达存在相关性(ρ=-0.5223,P<0.0001),miR-223-3p与ECT2蛋白表达存在相关性(χ^(2)=21.56,P<0.0001)。Kaplan-Meier生存分析显示:TNM分期、淋巴结转移、神经侵犯、miR-223-3p表达水平、ECT2表达水平对食管鳞状细胞癌患者的总生存期有影响。Cox比例风险模型发现TNM分期、淋巴结转移、神经侵犯、miR-223-3p表达水平、ECT2表达水平对总生存期有影响。结论miR-223-3p与ECT2的表达水平在食管鳞状细胞癌中存在相关性。TNM分期、淋巴结转移、神经侵犯、miR-223-3p表达水平、ECT2表达水平可作为ESCC的独立预后因素。 展开更多
关键词 miR-223-3p ECT2 食管鳞状细胞癌 相关性 预后
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通过卷积神经网络分析ECT成像和临床检验数据评估糖尿病视网膜病变和糖尿病肾病之间的相关性 被引量:5
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作者 唐娟 李庆华 +12 位作者 邓秀英 鲁婷 唐国强 林志武 刘兴德 吴小利 方其林 李盈 王潇 周燕 李彪 戴传强 李涛 《眼科新进展》 CAS 北大核心 2024年第2期127-132,共6页
目的从影像学和临床检验数据综合评估2型糖尿病患者(T2DM)中糖尿病肾病(DN)和糖尿病视网膜病变(DR)的相关性。方法选取2021年3月至2022年12月就诊于资阳市第一人民医院的T2DM患者600例,所有患者均行眼底照相和荧光素眼底血管造影检查,... 目的从影像学和临床检验数据综合评估2型糖尿病患者(T2DM)中糖尿病肾病(DN)和糖尿病视网膜病变(DR)的相关性。方法选取2021年3月至2022年12月就诊于资阳市第一人民医院的T2DM患者600例,所有患者均行眼底照相和荧光素眼底血管造影检查,收集患者年龄、性别、T2DM持续时间、心血管疾病、脑血管疾病、高血压、吸烟史、饮酒史、体重指数、收缩压和舒张压等临床数据。测量空腹血糖、甘油三酯、总胆固醇、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇、糖化血红蛋白、24 h尿白蛋白、尿白蛋白/肌酐、血肌酐和血尿素氮水平。采用Logistic回归分析与DR相关的危险因素。根据眼底图片进行DR分期,采用卷积神经网络(CNN)算法作为图像分析方法,通过ECT成像技术和临床检验数据评估DR和DN之间的相关性。结果采用CNN算法进行分析,无明显DR、轻度非增生型DR(NPDR)、中度NPDR、重度NPDR和增生型DR(PDR)组患者的DR和DN病变面积率均高于采用传统算法(TCM)的结果。随着DR的加重,患者血肌酐、血尿素氮、24 h尿白蛋白和尿白蛋白/肌酐均逐渐升高,无明显DR、轻度NPDR、中度NPDR、重度NPDR和PDR组患者的DN发生率分别为1.67%、8.83%、16.16%、22.16%和30.83%。Logistic回归分析结果显示,T2DM持续时间、吸烟史、糖化血红蛋白、总胆固醇、甘油三酯、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇、24 h尿白蛋白、血肌酐、血尿素氮、尿白蛋白/肌酐、肾小球滤过率是DR的独立危险因素。肾动态ECT成像分析结果表明,随着DR的加重,肾血流灌注逐渐减少,从而导致肾过滤功能下降。结论在T2DM患者中,CNN算法早期应用于DR和DN图像的分析,将有助于提高DR和DN病变面积诊断准确性,随着DR病变的加重,DN的严重程度逐渐增加。 展开更多
关键词 卷积神经网络 2型糖尿病 糖尿病视网膜病变 糖尿病肾病 ECT成像技术
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玉米ECT家族成员的全基因组分析及非生物胁迫下的响应表达 被引量:1
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作者 徐可丽 周美君 +5 位作者 郭怡婷 吉虹菁 黄敏 李曼菲 杜何为 刘睿 《核农学报》 CAS CSCD 北大核心 2024年第6期1035-1047,共13页
ECT结构域蛋白家族作为一种重要的转录后调控因子,在调控m6A修饰中发挥重要功能,在植物正常生长发育和响应逆境胁迫时的基因表达调控中具有重要作用。为了研究ECT结构域蛋白家族在玉米(Zea mays L.)非生物胁迫下的生长发育与胁迫响应中... ECT结构域蛋白家族作为一种重要的转录后调控因子,在调控m6A修饰中发挥重要功能,在植物正常生长发育和响应逆境胁迫时的基因表达调控中具有重要作用。为了研究ECT结构域蛋白家族在玉米(Zea mays L.)非生物胁迫下的生长发育与胁迫响应中的功能,本研究采用生物信息学方法鉴定到玉米ECT家族成员22个,并分析其序列和结构特征、染色体分布、启动子顺式作用元件、GO富集、蛋白质互作网络和系统发育进化关系,通过实时荧光定量PCR(qRT-PCR)分析了玉米ZmECTs在冷胁迫以及不同激素处理下的表达模式。结果表明,玉米ECT家族成员分布在10条染色体上,编码的蛋白质所含氨基酸残基数目为119~748 aa,相对分子量(MW)范围为13412.17~81823.70 Da,等电点(pI)范围为5.43~8.82,大部分蛋白定位在细胞核。在ZmECT家族中共鉴定到10个motif。顺式作用元件分析结果表明,ZmECT家族成员启动子包含多个与胁迫、激素和生长发育相关的响应元件。GO富集分析结果显示,ZmECT家族成员可能参与mRNA的剪接和维持RNA稳定性。蛋白质互作网络预测,ZmECT6是该家族蛋白的核心成员。系统进化树显示,ZmECT家族成员分为4组。qRT-PCR结果显示,经不同激素处理后,ZmECT家族成员表现出复杂的响应模式,部分ZmECT家族成员响应冷胁迫。本研究结果为玉米ECT基因后续的生物学功能解析及分子机制研究提供了参考。 展开更多
关键词 玉米(Zea mays L.) ECT家族 生物信息学 非生物胁迫 响应表达
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曲妥珠单抗联合ECT化疗方案对晚期乳腺癌患者疗效、血清CA153、CEA及造血功能影响 被引量:5
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作者 牛猛 董燕兵 +2 位作者 李孝涛 张俊生 张峰 《分子诊断与治疗杂志》 2024年第3期565-568,577,共5页
目的 探讨曲妥珠单抗联合表柔比星(E)+环磷酰胺(C)+紫杉醇(T)化疗方案对晚期乳腺癌患者疗效、血清癌抗原153(CA153)、癌胚抗原(CEA)及造血功能的影响。方法 选择安徽阜南县人民医院2019年10月至2022年10月收治的60例晚期乳腺癌患者,按... 目的 探讨曲妥珠单抗联合表柔比星(E)+环磷酰胺(C)+紫杉醇(T)化疗方案对晚期乳腺癌患者疗效、血清癌抗原153(CA153)、癌胚抗原(CEA)及造血功能的影响。方法 选择安徽阜南县人民医院2019年10月至2022年10月收治的60例晚期乳腺癌患者,按照随机数表法分为ECT组30例(接受表柔比星+环磷酰胺、多西他赛治疗)和联合组30例(ECT组基础上使用曲妥珠单抗),比较两组临床疗效、血清CA153、CEA、造血功能、不良反应。结果 联合组有效率高于ECT组(96.67%vs. 80.00%),差异有统计学意义(χ^(2)=4.043,P<0.05)。两组血清CA153、CEA均较治疗前降低,疗程结束时,联合组上述水平低于ECT组,差异有统计学意义(t=14.795、17.472,P<0.05)。两组血小板计数(PLT)、血红蛋白(Hb)、白细胞计数(WBC)均较治疗前降低,疗程结束时,两组上述指标及不良反应比较差异无统计学意义(t=1.052、1.751、1.676,P>0.05)。结论 相较于单一使用ECT化疗方案,ECT化疗方案联合曲妥珠单抗可以提高晚期乳腺癌患者临床疗效,降低血清CA153、CEA水平,且不会对患者造血功能造成影响。 展开更多
关键词 乳腺癌 晚期 曲妥珠单抗 ECT化疗方案 癌抗原153 癌胚抗原
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Boosted Electrocatalytic Glucose Oxidation Reaction on Noble-Metal-Free MoO_(3)-Decorated Carbon Nanotubes 被引量:1
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作者 Yu-Long Men Ning Dou +3 位作者 Yiyi Zhao Yan Huang Lei Zhang Peng Liu 《Transactions of Tianjin University》 EI CAS 2024年第1期63-73,共11页
Electrocatalytic glucose oxidation reaction(GOR)has attracted much attention owing to its crucial role in biofuel cell fabrication.Herein,we load MoO_(3)nanoparticles on carbon nanotubes(CNTs)and use a discharge proce... Electrocatalytic glucose oxidation reaction(GOR)has attracted much attention owing to its crucial role in biofuel cell fabrication.Herein,we load MoO_(3)nanoparticles on carbon nanotubes(CNTs)and use a discharge process to prepare a noblemetal-free MC-60 catalyst containing MoO_(3),Mo_(2)C,and a Mo_(2)C–MoO_(3)interface.In the GOR,MC-60 shows activity as high as 745μA/(mmol/L cm^(2)),considerably higher than those of the Pt/CNT(270μA/(mmol/L cm^(2)))and Au/CNT catalysts(110μA/(mmol/L cm^(2))).In the GOR,the response minimum on MC-60 is as low as 8μmol/L,with a steady-state response time of only 3 s.Moreover,MC-60 has superior stability and anti-interference ability to impurities in the GOR.The better performance of MC-60 in the GOR is attributed to the abundant Mo sites bonding to C and O atoms at the MoO_(3)–Mo_(2)C interface.These Mo sites create active sites for promoting glucose adsorption and oxidation,enhancing MC-60 performance in the GOR.Thus,these results help to fabricate more effi cient noble-metal-free catalysts for the fabrication of glucose-based biofuel cells. 展开更多
关键词 Interface eff ect ELECTROCATALYSIS Molybdenum oxide GLUCOSE Oxidation reaction
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基于1-bit压缩感知非凸算法的平面ECT图像重建
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作者 唐志浩 张立峰 《计量学报》 CSCD 北大核心 2024年第12期1797-1803,共7页
为提高平面电容成像系统的成像质量并提高重建速度,提出了一种基于1-bit压缩感知(1-bit CS)非凸算法的平面ECT图像重建方法。首先,利用离散余弦基(DCT)对灰度值进行稀疏表示;其次,引入极大极小凹惩罚(MCP)作为正则化项,并建立1-bit CS ... 为提高平面电容成像系统的成像质量并提高重建速度,提出了一种基于1-bit压缩感知(1-bit CS)非凸算法的平面ECT图像重建方法。首先,利用离散余弦基(DCT)对灰度值进行稀疏表示;其次,引入极大极小凹惩罚(MCP)作为正则化项,并建立1-bit CS MCP正则化模型;然后,通过MCP非凸算法迭代更新对偶解的近端算子,以求取最优对偶解;最后,根据对偶解求出重建灰度值并进行图像重建。仿真与实验结果表明,相比于Tikhonov算法、Landweber算法及传统压缩感知算法,所提方法得到的重建图像平均相对误差和相关系数分别为0.0496和0.9435,平均重建时间约为0.1723 s,均优于其他3种算法,缺陷还原度及重建速度有明显提升。 展开更多
关键词 材料缺陷检测 平面电容成像 ECT图像重建 1-bit压缩感知 极大极小凹惩罚 非凸算法
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