Over 200,000 Chinese sturgeons in di"erent age groups ranging from infant to 15 years old were released into the Yangtze River on 28 March during the annual release event designed to bolster the population of thi...Over 200,000 Chinese sturgeons in di"erent age groups ranging from infant to 15 years old were released into the Yangtze River on 28 March during the annual release event designed to bolster the population of this endangered species and raise public awareness.The event,organised by the Ministry of Agriculture and Rural A"airs of China and China Three Gorges Group(CTG),took place in Yichang City,central China’s Hubei Province.展开更多
The transforming growth factor β1（TGF-β1） and CD8-positive T cells are two important immune factors that function at opposite directions. The purpose of this study was to verify the relationship between the two fa...The transforming growth factor β1（TGF-β1） and CD8-positive T cells are two important immune factors that function at opposite directions. The purpose of this study was to verify the relationship between the two factors and their associations with long-term effects of adjuvant chemotherapy or endocrine therapy in breast cancer. Expression of TGF-β1 precursor and CD8 was immunohistochemically detected on surgically-obtained tumor samples of 130（stageⅠ–Ⅲ） invasive breast carcinomas from Chinese subjects, who were followed up for a mean time of 112 months. Interstitial CD8-positive cells and TGF-β1 precursor-positive cells adjacent to tumor nests were counted. Infiltration of CD8-positive lymphocytes into tumor nests and TGF-β1 precursor expression in tumor cells were observed and survival analysis was performed. Our results showed that density of interstitial CD8-positive lymphocytes was an independent adverse prognostic factor for distant disease-free survival（DDFS）（HR=8.416, 95% CI=1.636–43.292, P=0.011） in hormone receptor-positive patients who were on adjuvant endocrine therapy. For breast cancer patients who did not receive adjuvant chemotherapy, those without infiltration of CD8-positive cells into tumor nests had a shorter overall survival（OS） than their counterparts with CD8-positive cell infiltration into tumor nests（Log-Rank, P=0.003）. But OS of patients without infiltration of CD8-positive cells into tumor nests was significantly prolonged by adjuvant chemotherapy（Log-Rank, P=0.013） and paralleled that of patients with CD8-positive cell infiltration. Although OS was shorter in the tumor cell TGF-β1 precursor（t-TGF-β1-pre）-positive patients than in the negative patients in patients without recieiving chemotherapy（P=0.053）, OS of t-TGF-β1-pre-positive patients was significantly prolonged by adjuvant chemotherapy（P=0.035） and was longer than that of t-TGF-β1-pre-negative patients. Analysis showed that t-TGF-β1-pre was an independent positive prognostic factor for DDFS（HR=0.392 95% CI=0.157–0.978, P=0.045） in patients who received adjuvant chemotherapy. This study suggested that density of interstitial CD8-positive lymphocytes was of prognostic value in hormone receptor-positive patients who received adjuvant endocrine therapy. Our study verified that adverse immunologic signatures consisting of absence of CD8-positive cells in tumor nests or expression of TGF-β1 precursor in tumor cells in breast cancer were associated with worse prognosis and significantly improved long-term survival with adjuvant chemotherapy, respectively.展开更多
Chaihu plus Longgu Muli Decoction is the representative treatment method of harmonizing and releasing combined with easing for lesser yang disease proposed by famous physician Zhang Zhongjing.Through clinical cases,th...Chaihu plus Longgu Muli Decoction is the representative treatment method of harmonizing and releasing combined with easing for lesser yang disease proposed by famous physician Zhang Zhongjing.Through clinical cases,this paper firstly introduced the main framework of Chaihu plus Longgu Muli Decoction,to make the treatment method of harmonizing and releasing become more flexible in clinical application.Besides,it introduced the common changes in the learning and application of the decoction,to respond to various changes in the clinical diseases.展开更多
The shape of body and the ease of garment are the important elements in constructing garment style. However, the distribution of ease in garment is uneven and the curves showing different cross-sections of garment sty...The shape of body and the ease of garment are the important elements in constructing garment style. However, the distribution of ease in garment is uneven and the curves showing different cross-sections of garment style with ease are unavailable in the literature. This information is crucial when the three-dimensional garment style is transformed into two-dimensional garment patterns. Thus, several different X-line style garments are produced by 3D draping technology, and the cubic spline is used to fit the cross sectional curves of BL, WL of body and garment. By comparing cross sections of body and garment, the ease at different location can be derived. Besides, garments in 10 different dimensions and quantities of style ease are included in the current study. By numerical operation on discrete ease data at different location, the fitted functions of ease distribution are obtained.展开更多
In the last half century,a significant warming trend occurred in summer over eastern China in the East Asian monsoon region.However,there were no consistent trends with respect to the intensity of the East Asian summe...In the last half century,a significant warming trend occurred in summer over eastern China in the East Asian monsoon region.However,there were no consistent trends with respect to the intensity of the East Asian summer monsoon(EASM) or the amount of summer rainfall averaged over eastern China.Both of the EASM and summer rainfall exhibited clear decadal variations.Obvious decadal shifts of EASM occurred around the mid- and late 1970 s,the late 1980 s and the early 1990 s,and the late 1990 s and early 2000 s,respectively.Summer rainfall over eastern China exhibited a change in spatial distribution in the decadal timescale,in response to the decadal shifts of EASM.From the mid- and late 1970 s to the late 1980 s and the early 1990 s,there was a meridional tri-polar rainfall distribution anomaly with more rainfall over the Yangtze River valley and less rainfall in North and South China; but in the period from the early 1990 s to the late 1990 s and the early 2000 s the tri-polar distribution changed to a dipolar one,with more rainfall appearing over southern China south to the Yangtze River valley and less rainfall in North China.However,from the early 2000 s to the late 2000 s,the Yangtze River valley received less rainfall.The decadal changes in EASM and summer rainfall over eastern China in the last half century are closely related to natural internal forcing factors such as Eurasian snow cover,Arctic sea ice,sea surface temperatures in tropical Pacific and Indian Ocean,oceaneatmospheric coupled systems of the Pacific Decadal Oscillation(PDO) and AsianePacific Oscillation(APO),and uneven thermal forcing over the Asian continent.Up to now,the roles of anthropogenic factors,such as greenhouse gases,aerosols,and land usage/cover changes,on existing decadal variations of EASM and summer rainfall in this region remain uncertain.展开更多
Patients with inflammatory bowel disease (IBD) have an increased risk of vascular complications. Thromboembolic complications, both venous and arterial, are serious extraintestinal manifestations complicating the cour...Patients with inflammatory bowel disease (IBD) have an increased risk of vascular complications. Thromboembolic complications, both venous and arterial, are serious extraintestinal manifestations complicating the course of IBD and can lead to significant morbidity and mortality. Patients with IBD are more prone to thromboembolic complications and IBD per se is a risk factor for thromboembolic disease. Data suggest that thrombosis is a specific feature of IBD that can be involved in both the occurrence of thromboembolic events and the pathogenesis of the disease. The exact etiology for this special association between IBD and thromboembolism is as yet unknown, but it is thought that multiple acquired and inherited factors are interacting and producing the increased tendency for thrombosis in the local intestinal microvasculature, as well as in the systemic circulation. Clinicians’ awareness of the risks, and their ability to promptly diagnose and manage tromboembolic complications are of vital importance. In this review we discuss how thromboembolic disease is related to IBD, specifically focusing on: (1) the epidemiology and clinical features of thromboembolic complications in IBD; (2) the pathophysiology of thrombosis in IBD; and (3) strategies for the prevention and management of thromboembolic complications in IBD patients.展开更多
文摘Over 200,000 Chinese sturgeons in di"erent age groups ranging from infant to 15 years old were released into the Yangtze River on 28 March during the annual release event designed to bolster the population of this endangered species and raise public awareness.The event,organised by the Ministry of Agriculture and Rural A"airs of China and China Three Gorges Group(CTG),took place in Yichang City,central China’s Hubei Province.
基金supported by the Wu Jieping Medical Foun-dation(No.320.6752.1230)
文摘The transforming growth factor β1（TGF-β1） and CD8-positive T cells are two important immune factors that function at opposite directions. The purpose of this study was to verify the relationship between the two factors and their associations with long-term effects of adjuvant chemotherapy or endocrine therapy in breast cancer. Expression of TGF-β1 precursor and CD8 was immunohistochemically detected on surgically-obtained tumor samples of 130（stageⅠ–Ⅲ） invasive breast carcinomas from Chinese subjects, who were followed up for a mean time of 112 months. Interstitial CD8-positive cells and TGF-β1 precursor-positive cells adjacent to tumor nests were counted. Infiltration of CD8-positive lymphocytes into tumor nests and TGF-β1 precursor expression in tumor cells were observed and survival analysis was performed. Our results showed that density of interstitial CD8-positive lymphocytes was an independent adverse prognostic factor for distant disease-free survival（DDFS）（HR=8.416, 95% CI=1.636–43.292, P=0.011） in hormone receptor-positive patients who were on adjuvant endocrine therapy. For breast cancer patients who did not receive adjuvant chemotherapy, those without infiltration of CD8-positive cells into tumor nests had a shorter overall survival（OS） than their counterparts with CD8-positive cell infiltration into tumor nests（Log-Rank, P=0.003）. But OS of patients without infiltration of CD8-positive cells into tumor nests was significantly prolonged by adjuvant chemotherapy（Log-Rank, P=0.013） and paralleled that of patients with CD8-positive cell infiltration. Although OS was shorter in the tumor cell TGF-β1 precursor（t-TGF-β1-pre）-positive patients than in the negative patients in patients without recieiving chemotherapy（P=0.053）, OS of t-TGF-β1-pre-positive patients was significantly prolonged by adjuvant chemotherapy（P=0.035） and was longer than that of t-TGF-β1-pre-negative patients. Analysis showed that t-TGF-β1-pre was an independent positive prognostic factor for DDFS（HR=0.392 95% CI=0.157–0.978, P=0.045） in patients who received adjuvant chemotherapy. This study suggested that density of interstitial CD8-positive lymphocytes was of prognostic value in hormone receptor-positive patients who received adjuvant endocrine therapy. Our study verified that adverse immunologic signatures consisting of absence of CD8-positive cells in tumor nests or expression of TGF-β1 precursor in tumor cells in breast cancer were associated with worse prognosis and significantly improved long-term survival with adjuvant chemotherapy, respectively.
文摘Chaihu plus Longgu Muli Decoction is the representative treatment method of harmonizing and releasing combined with easing for lesser yang disease proposed by famous physician Zhang Zhongjing.Through clinical cases,this paper firstly introduced the main framework of Chaihu plus Longgu Muli Decoction,to make the treatment method of harmonizing and releasing become more flexible in clinical application.Besides,it introduced the common changes in the learning and application of the decoction,to respond to various changes in the clinical diseases.
文摘The shape of body and the ease of garment are the important elements in constructing garment style. However, the distribution of ease in garment is uneven and the curves showing different cross-sections of garment style with ease are unavailable in the literature. This information is crucial when the three-dimensional garment style is transformed into two-dimensional garment patterns. Thus, several different X-line style garments are produced by 3D draping technology, and the cubic spline is used to fit the cross sectional curves of BL, WL of body and garment. By comparing cross sections of body and garment, the ease at different location can be derived. Besides, garments in 10 different dimensions and quantities of style ease are included in the current study. By numerical operation on discrete ease data at different location, the fitted functions of ease distribution are obtained.
基金supported by the National Natural Science Foundation of China (41221064)
文摘In the last half century,a significant warming trend occurred in summer over eastern China in the East Asian monsoon region.However,there were no consistent trends with respect to the intensity of the East Asian summer monsoon(EASM) or the amount of summer rainfall averaged over eastern China.Both of the EASM and summer rainfall exhibited clear decadal variations.Obvious decadal shifts of EASM occurred around the mid- and late 1970 s,the late 1980 s and the early 1990 s,and the late 1990 s and early 2000 s,respectively.Summer rainfall over eastern China exhibited a change in spatial distribution in the decadal timescale,in response to the decadal shifts of EASM.From the mid- and late 1970 s to the late 1980 s and the early 1990 s,there was a meridional tri-polar rainfall distribution anomaly with more rainfall over the Yangtze River valley and less rainfall in North and South China; but in the period from the early 1990 s to the late 1990 s and the early 2000 s the tri-polar distribution changed to a dipolar one,with more rainfall appearing over southern China south to the Yangtze River valley and less rainfall in North China.However,from the early 2000 s to the late 2000 s,the Yangtze River valley received less rainfall.The decadal changes in EASM and summer rainfall over eastern China in the last half century are closely related to natural internal forcing factors such as Eurasian snow cover,Arctic sea ice,sea surface temperatures in tropical Pacific and Indian Ocean,oceaneatmospheric coupled systems of the Pacific Decadal Oscillation(PDO) and AsianePacific Oscillation(APO),and uneven thermal forcing over the Asian continent.Up to now,the roles of anthropogenic factors,such as greenhouse gases,aerosols,and land usage/cover changes,on existing decadal variations of EASM and summer rainfall in this region remain uncertain.
文摘Patients with inflammatory bowel disease (IBD) have an increased risk of vascular complications. Thromboembolic complications, both venous and arterial, are serious extraintestinal manifestations complicating the course of IBD and can lead to significant morbidity and mortality. Patients with IBD are more prone to thromboembolic complications and IBD per se is a risk factor for thromboembolic disease. Data suggest that thrombosis is a specific feature of IBD that can be involved in both the occurrence of thromboembolic events and the pathogenesis of the disease. The exact etiology for this special association between IBD and thromboembolism is as yet unknown, but it is thought that multiple acquired and inherited factors are interacting and producing the increased tendency for thrombosis in the local intestinal microvasculature, as well as in the systemic circulation. Clinicians’ awareness of the risks, and their ability to promptly diagnose and manage tromboembolic complications are of vital importance. In this review we discuss how thromboembolic disease is related to IBD, specifically focusing on: (1) the epidemiology and clinical features of thromboembolic complications in IBD; (2) the pathophysiology of thrombosis in IBD; and (3) strategies for the prevention and management of thromboembolic complications in IBD patients.
