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边界因子和E-value在流行病学敏感性分析中的研究进展
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作者 王佳乐 高倩 +1 位作者 王菊平 王彤 《中国卫生统计》 北大核心 2025年第4期626-631,共6页
目的 流行病学研究结果常因未测量混杂因素、选择偏倚和测量误差的存在而在评价因果效应方面受到质疑。对这些偏倚来源进行敏感性分析可以提供结论稳健性的证据。边界因子(bounding factor, BF)和E-value是近年来提出的敏感性分析方法,... 目的 流行病学研究结果常因未测量混杂因素、选择偏倚和测量误差的存在而在评价因果效应方面受到质疑。对这些偏倚来源进行敏感性分析可以提供结论稳健性的证据。边界因子(bounding factor, BF)和E-value是近年来提出的敏感性分析方法,因对未测量混杂因素不作任何假设和计算简单而受欢迎,已经拓展到选择偏倚和差分测量误差的敏感性分析领域。本研究对现有BF和E-value方法进行概述,以期推广其在流行病学研究中的使用,提供因果关联稳健性的证据。方法 针对未测量混杂因素,选择偏倚和差分测量误差三方面偏倚来源,回顾边界因子和E-value在敏感性分析中的原理和应用。结果 BF尤其是E-value提供了一种简单的敏感性分析方法来评估因果关联的稳健性。结论 建议研究者在所有旨在探索因果效应的研究中都计算并常规报告效应估计的E-value,并结合其他可行的敏感性分析方法充分验证因果结论的稳健性。 展开更多
关键词 敏感性分析 边界因子 e-value 未测量混杂 选择偏倚 差分测量误差
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观察性研究的敏感性分析:“E-value”解读 被引量:3
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作者 姜棋予 孙丽君 毕京峰 《中国医药导报》 CAS 2020年第11期181-185,192,共6页
通过对敏感性分析新方法E-value的解读,向读者介绍一种简单实用的观察性研究敏感性分析方法。该方法以相对危险度(RR)作为主要研究指标,构建了RR敏感性分析的统计学模型,从而预测能够将研究结果(RR值)解释掉的,未知混杂因素与暴露因素... 通过对敏感性分析新方法E-value的解读,向读者介绍一种简单实用的观察性研究敏感性分析方法。该方法以相对危险度(RR)作为主要研究指标,构建了RR敏感性分析的统计学模型,从而预测能够将研究结果(RR值)解释掉的,未知混杂因素与暴露因素及结局的最小关联强度。该方法还通过统计学转换,将RR推广到优势比、风险比及结局变化的均值的敏感性分析。该方法为观察性研究的敏感性分析提供了一种简单、可靠的分析方法,建议在以后的观察性研究报告及论文发表中提供相应的敏感性分析结果,但须注意,该敏感性分析并不能替代严谨的科研设计。 展开更多
关键词 观察性研究 敏感性分析 e-value 解读
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Pre Impoundment Studies in Monday River, Eastern Paraguay I: Soils and Submerged Soils
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作者 Juan F Facetti-Masulli Carmelo López Amado González 《Journal of Chemistry and Chemical Engineering》 2019年第2期82-92,共11页
Monday River, at Eastern Paraguay is located south of the Itaipu Dam, and discharges into the Paraná River. At the point of discharge it has been projected to build a Hydroelectric power Plant and the reservoir w... Monday River, at Eastern Paraguay is located south of the Itaipu Dam, and discharges into the Paraná River. At the point of discharge it has been projected to build a Hydroelectric power Plant and the reservoir will extend upstream the Monday. As a result of the impoundment of a river, the flooded soil can provide a certain amount of nutrients into the aqueous medium setting new conditions for aquatic life and affecting to a greater or lesser degree the ecosystems. The aim of this work is the assessment of the impact on the water quality of the incorporation of major nutrients into the water body after damming Monday River. Samples from soil profiles were taken at selected sites on both banks of the river;the amount of phosphorus, nitrogen, potassium, calcium and magnesium as well as other parameters as pH, organic matter, exchangeable bases were determined using standard procedures. Granulometric analysis was also performed. Phosphorus availability was determined by isotopic exchange. In addition the samples were submitted to submersion/incubation experiments along 60 days, and the concentration of elements incorporated into the water analyzed. Results show that flooded soils are low in phosphorus and nitrogen which is scarce in some cases;so does other nutrients. Submersion experiments also indicate generally limited incorporation of such nutrients into the water body. Significant negative impact of these soils on the water quality of the reservoir cannot be expected. 展开更多
关键词 ALTO Paraná Dpt Monday RIVER SOILS e-value INCUBATION experiments
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