Quantitative structure-retention relationship(QSRR)is an important tool in chromatography.QSRR examines the correlation between molecular structures and their retention behaviors during chromatographic separation.This...Quantitative structure-retention relationship(QSRR)is an important tool in chromatography.QSRR examines the correlation between molecular structures and their retention behaviors during chromatographic separation.This approach involves developing models for predicting the retention time(RT)of analytes,thereby accelerating method development and facilitating compound identification.In addition,QSRR can be used to study compound retention mechanisms and support drug screening efforts.This review provides a comprehensive analysis of QSRR workflows and applications,with a special focus on the role of artificial intelligence-an area not thoroughly explored in previous reviews.Moreover,we discuss current limitations in RT prediction and propose promising solutions.Overall,this review offers a fresh perspective on future QSRR research,encouraging the development of innovative strategies that enable the diverse applications of QSRR models in chromatographic analysis.展开更多
By investigating the types of 371 non-English major freshmen's use of mother-tongue-reliance strategies in English languagelearning,the study showed that students' use of mother-tongue-reliance strategies woul...By investigating the types of 371 non-English major freshmen's use of mother-tongue-reliance strategies in English languagelearning,the study showed that students' use of mother-tongue-reliance strategies would vary significantly with their different L2 profi-ciency.And it was negatively correlated with L2 proficiency.And the study discussed the implications to guide English language teach-ing and learning.展开更多
The increasing use of diesel-powered equipment in confined spaces(underground mines) has the potential to over expose underground miners under the threat of diesel particulate matter(DPM). Miners in underground mines ...The increasing use of diesel-powered equipment in confined spaces(underground mines) has the potential to over expose underground miners under the threat of diesel particulate matter(DPM). Miners in underground mines can be exposed to DPM concentrations far more than works in other industries. A great number of animal and epidemiological studies have shown that both short-term and long-term DPM exposure have adverse health effect. Based on reviews of related studies, especially some recent evidence, this paper investigated the long and short-term health effects based on animal studies and epidemiological studies. The exposure-response relationship studies were also explored and compared to the current DPM regulation or standards in some countries. This paper found that the DPM health effect studies specifically for miners are not sufficient to draw solid conclusions, and a recommendation limit of DPM concentration can be put in place for better protection of miners from DPM health risk. Current animal studies lack the use of species that have similar lung functions as human for understanding the cancer mode of action in human. And finally, the DPM health hazard will continue to be a challenging topic before the mode of action and reliable exposure-response relationship are established.展开更多
In the present study,（QSRR） study had been carried out for volatile components from Rosa banksiae Ait.based on various quantum-chemical and physicochemical descriptors derived by B3LYP method.To build QSRR models,a ...In the present study,（QSRR） study had been carried out for volatile components from Rosa banksiae Ait.based on various quantum-chemical and physicochemical descriptors derived by B3LYP method.To build QSRR models,a multiple linear regression （MLR） stepwise method was used.The generated models have good predictive ability and are of high statistical significance with good correlation coefficients （R2≥0.734） and p values far less than 0.05.Preliminary results indicated that the application of the models,especially the prediction of GC retention time and linear retention index of volatile components from Rosa banksiae Ait.,will be helpful.The models contribute also to the identification of important quantum-chemical and physicochemical descriptors responsible for the retention time and linear retention index.It was found that the shape attribute （ShpA） and logP value play a vital role in determining component’s GC retention time and linear retention index which increase with the lipophilicity of volatile components.The larger the shape attribute of analyte is,the larger the deformability is,the stronger the interaction between analyte and stationary phase is,and the longer the GC retention time is,the larger the linear retention index is.The importance of E HOMO,q＋,and SEV is also embodied in models,but they are not dominant.展开更多
Polychlorinated dibenzothiophenes（PCDTs） are classified as persistent organic pollutants in the environment,so the analysis of PCDTs by their gas chromatographic behaviors is of great significance.Quantitative struc...Polychlorinated dibenzothiophenes（PCDTs） are classified as persistent organic pollutants in the environment,so the analysis of PCDTs by their gas chromatographic behaviors is of great significance.Quantitative structure-retention relationship（QSRR） analysis is a useful technique capable of relating chromatographic retention time to the molecular structure.In this paper,a QSRR study of 37 PCDTs was carried out by using molecular electronegativity distance vector（MEDV） descriptors and multiple linear regression（MLR） and partial least-squares regression（PLS） methods.The correlation coefficient R of established MLR,PLS models,leave-one-out（LOO） cross-validation（CV）,Q2ext were 0.9951,0.9942,0.9839（MLR） and 0.9925,0.9915,0.9833（PLS）,respectively.Results showed that the model exhibited excellent estimate capability for internal sample set and good predictive capability for external sample set.By using MEDV descriptors,the QSRR model can provide a simple and rapid way to predict the gas-chromatographic retention indices of polychlorinated dibenzothiophenes in conditions of lacking standard samples or poor experimental conditions.展开更多
BACKGROUND The epidemiological and clinical characteristics of coronavirus disease 2019(COVID-19)patients have been widely reported,but the assessment of doseresponse relationships and risk factors for mortality and s...BACKGROUND The epidemiological and clinical characteristics of coronavirus disease 2019(COVID-19)patients have been widely reported,but the assessment of doseresponse relationships and risk factors for mortality and severe cases and clinical outcomes remain unclear.AIM To determine the dose-response relationship between risk factors and incidence of COVID-19.METHODS In this retrospective,multicenter cohort study,we included patients with confirmed COVID-19 infection who had been discharged or had died by February 6,2020.We used multivariable logistic regression and Cox proportional hazard models to determine the dose-response relationship between risk factors and incidence of COVID-19.RESULTS It clarified that increasing risk of in-hospital death were associated with older age(HR:1.04,95%CI:1.01-1.09),higher lactate dehydrogenase[HR:1.04,95%confidence interval(CI):1.01-1.10],C-reactive protein(HR:1.10,95%CI:1.01-1.23),and procalcitonin(natural log-transformed HR:1.88,95%CI:1.22-2.88),and D-dimer greater than 1μg/m L at admission(natural log transformed HR:1.63,95%CI:1.03-2.58)by multivariable regression.D-dimer and procalcitonin were logarithmically correlated with COVID-19 mortality risk,while there was a linear dose-response correlation between age,lactate dehydrogenase,D-dimer and procalcitonin,independent of established risk factors.CONCLUSION Higher lactate dehydrogenase,D-dimer,and procalcitonin levels were independently associated with a dose-response increased risk of COVID-19 mortality.展开更多
In the international shipping industry, digital intelligence transformation has become essential, with both governments and enterprises actively working to integrate diverse datasets. The domain of maritime and shippi...In the international shipping industry, digital intelligence transformation has become essential, with both governments and enterprises actively working to integrate diverse datasets. The domain of maritime and shipping is characterized by a vast array of document types, filled with complex, large-scale, and often chaotic knowledge and relationships. Effectively managing these documents is crucial for developing a Large Language Model (LLM) in the maritime domain, enabling practitioners to access and leverage valuable information. A Knowledge Graph (KG) offers a state-of-the-art solution for enhancing knowledge retrieval, providing more accurate responses and enabling context-aware reasoning. This paper presents a framework for utilizing maritime and shipping documents to construct a knowledge graph using GraphRAG, a hybrid tool combining graph-based retrieval and generation capabilities. The extraction of entities and relationships from these documents and the KG construction process are detailed. Furthermore, the KG is integrated with an LLM to develop a Q&A system, demonstrating that the system significantly improves answer accuracy compared to traditional LLMs. Additionally, the KG construction process is up to 50% faster than conventional LLM-based approaches, underscoring the efficiency of our method. This study provides a promising approach to digital intelligence in shipping, advancing knowledge accessibility and decision-making.展开更多
The dose-response relationship for asbestos exposure in a chrysotile product factory was studied. The past gravimetric dust concentration values, obtained from different worksites, were converted into fiber concentrat...The dose-response relationship for asbestos exposure in a chrysotile product factory was studied. The past gravimetric dust concentration values, obtained from different worksites, were converted into fiber concentration values according to conversion factors that were worked out by simultaneous sampling in this study. The conversions were made so that exposure could be expressed in fiber-years (f-yr). Asbestosis was diagnosed on the basis of chest radiographs and occupational histories. Cumulative dust exposure (f-yr) was calculated up to the date of diagnosis for asbestosis patients, and up to September 1982 for the remaining workers. A dose-response relationship expressed as fiber-years exposed vs cumulative prevalence of asbestosis was established by the life table method on the basis of these data. Predicted 3 and 1% prevalence of asbestosis corresponded to 43 and 22 f-yr exposure, respectively. Considering that a worker can work for 35 years, these doses are commensurate with dust concentrations of 1.22 and 0.63 f/ml, respectively. It is recommended that 1 f/ml be taken as the maximum allowable concentration of airborne asbestos dust for the workplace with an anticipated prevalence of about 2% asbestosis after 35 years of exposure. 1990 Academic Press, Inc.展开更多
In this editorial,I comment on the article by Zhang et al.To emphasize the importance of the topic,I discuss the relationship between the use of smart medical devices and mental health.Smart medical services have the ...In this editorial,I comment on the article by Zhang et al.To emphasize the importance of the topic,I discuss the relationship between the use of smart medical devices and mental health.Smart medical services have the potential to positively influence mental health by providing monitoring,insights,and inter-ventions.However,they also come with challenges that need to be addressed.Understanding the primary purpose for which individuals use these smart tech-nologies is essential to tailoring them to specific mental health needs and prefe-rences.展开更多
This study investigated the role of intentional self-regulation and the moderating role of peer relationship in the relationship between teacher-student relationship and learning engagement.The study sample comprised ...This study investigated the role of intentional self-regulation and the moderating role of peer relationship in the relationship between teacher-student relationship and learning engagement.The study sample comprised 540 Chinese senior secondary school students between the ages of 15–18(51.67%boys;Mage=16.56 years;SDage=0.90).They completed surveys on the Teacher-Student Relationship Scale,the Selection,Optimization,and Compensation(SOC)Scale,the Peer Relationship Scale for Children and Adolescents,and the Learning Engagement Scale.The results following regression analysis showed that teacher-student relationship predicted higher learning engagement among senior secondary school students.Intentional self-regulation partially mediated the link between teacher-student relationship and learning engagement for higher learning engagement.Peer relationship moderated the relationships between teacher-student relationship and learning engagement and moderated the relationship between teacher-student relationship and intentional self-regulation for higher learning engagement.Thesefindings imply learning engagement can be enhanced by optimizing teacher-student relationship and strengthening intentional self-regulation interventions.展开更多
The relationship between ecosystem services(ES)and human well-being(HWB)is fundamental to the science and practice of sustainability.However,studies have shown conflicting results,which has been attributed to the infl...The relationship between ecosystem services(ES)and human well-being(HWB)is fundamental to the science and practice of sustainability.However,studies have shown conflicting results,which has been attributed to the influences of indicators,contexts,and scales.Yet,another potential factor,which has been overlooked,may be the mixed use of spatial and temporal approaches.Using twelve ES and seven well-being indicators and multiple statistical methods,we quantified and compared the spatial and temporal ES–HWB relationships for Inner Mongolia,China.The spatial and temporal relationships differed in both correlation direction and strength.Most relationships of economic and employment-related indicators with food provisioning and supporting services were temporally positive but spatially nonsignificant or negative.Some relationships of economic and employmentrelated indicators with water retention,sandstorm prevention,and wind erosion were temporally negative but spatially complex.However,the spatial and temporal ES–HWB relationships could also be similar in some cases.We conclude that although both the spatial and temporal approaches have merits,space generally cannot substitute for time in the study of ES–HWB relationship.Our study helps reconcile the seemingly conflicting findings in the literature,and suggests that future studies should explicitly distinguish between the spatial and temporal ES–HWB relationships.展开更多
This study examined the impact of teacher-student relationship quality on students’risk of bullying victimiza-tion and the mediating roles of student-student relationships and student engagement in this relationship....This study examined the impact of teacher-student relationship quality on students’risk of bullying victimiza-tion and the mediating roles of student-student relationships and student engagement in this relationship.A total of 656 Chinese junior high school students(females=361,mean age=13.75,SD=0.98)completed validated measures of teacher-student relationship quality,student-student relationship quality,student engagement,and bullying victimization.Regression analysis results indicated that higher teacher-student relationship quality predicted a lower risk of student bullying victimization.Serial mediating effect testing of the student-student relationship quality and student engagement revealed that these factors fully mediated the relationship between teacher-student relationship quality and bullying victimization,resulting in a lower risk of bullying victimization.The results showed that student-student relationship quality had a more substantial mediating effect than student engagement.Thefindings support the Socio-Ecological Framework,suggesting that within the Microsystem,interactions between individuals and their immediate environments significantly impact their behavior.Specifically,thesefindings suggest that good teacher-student relationships can enhance the quality of student-student relationships and student engagement,thereby preventing and reducing the occurrence of bullying victimization.展开更多
Soybean is widely used in diets,and numerous reports have highlighted its antioxidant properties.However,constructing a methodology for rapid identifying and predicting a series of antioxidant active ingredients in So...Soybean is widely used in diets,and numerous reports have highlighted its antioxidant properties.However,constructing a methodology for rapid identifying and predicting a series of antioxidant active ingredients in Soybean presents certain challenges.Therefore,we introduced the spectrum-effect relationship-ingredient knockout identification technique to identify a series of antioxidant active ingredients in soybean.By combining untargeted metabolomics with network pharmacology,we predicted the antioxidant active ingredients and their target sites.We successfully identified 4 antioxidant active compounds(daidzein,genistein,daidzein,and glycitin)and 10 corresponding antioxidant targets(epidermal growth factor receptor(EGFR),estrogen receptor 1(ESR1),steroid receptor coactivator(SRC),tumor necrosis factor(TNF),kinase insert domain receptor(KDR),AKT serine/threonine kinase 1(AKT1),growth factor receptor bound protein 2(GRB2),signal transducer and activator of transcription1(STAT1),mitogen-activated protein kinase 8(MAPK8),B-cell lymphoma-2(BCL2))by our analysis.The validation results from cell experiments revealed that glycitin exhibited the best antioxidant activity and significantly influenced the expression of EGFR and the proteins associated with nuclear factor erythroid 2-related factor 2/NAD(P)H quinone dehydrogenase 1(NRF2/NQO1)signaling pathways.These findings were consistent with the predicted outcomes and were further confirmed in a zebrafish model.It suggests that glycitin may exert antioxidant effects by regulating the expression of EGFR,NRF2,and NQO1 proteins.The results demonstrate that a rapid analytical method for determining antioxidant activity was established.展开更多
Since China’s reform and development,under the influence of the global religious and cultural boom,it has also focused on studying Islamic culture and related fields,resulting in many important representative works.T...Since China’s reform and development,under the influence of the global religious and cultural boom,it has also focused on studying Islamic culture and related fields,resulting in many important representative works.The main characteristic of writing books in this area is to use popular knowledge materials that are suitable for various sectors of society.There are also works exploring the historical evolution of Islamic culture in China,which involve the relationship between Islamic culture and traditional Chinese culture.Before the 1980s,there were no significant achievements in publishing papers.However,since the 1990s,there has been a noticeable increase in papers related to Islamic culture and related fields,with new advances in research areas and methods.There are both articles that explore the attributes and characteristics of Islamic culture from the perspectives of world history and culture,as well as many articles that explore various specific aspects of Islamic culture from the perspective of specific topics.In this article,the author collects academic achievements in the study of Islamic culture in China and introduces them to the academic community,letting them know about China's research on world Islamic culture.展开更多
BACKGROUND Hyperglycemia secondary to diabetes can lead to organ failure unless properly controlled,and it is associated with numerous health issues,particularly metabolic problems.Breast cancer is one of the most com...BACKGROUND Hyperglycemia secondary to diabetes can lead to organ failure unless properly controlled,and it is associated with numerous health issues,particularly metabolic problems.Breast cancer is one of the most common malignancies in females worldwide and represents a major health concern due to its morbidity and mortality.The progression of the disease and the response to treatment depend on numerous variables,including both tumor biology and patient-related factors.Key prognostic indicators include age,tumor size,lymph node involvement,histological type,hormone receptor status,and expression of biomarkers such as HER2.AIM To investigate the relationship between preoperative blood glucose levels and cancer prognostic factors in patients diagnosed with breast cancer.METHODS In this study patients diagnosed with breast cancer were classified into two groups:Those with blood glucose levels<125 mg/dL and those with levels>125 mg/dL.Estrogen and progesterone receptor positivity,Ki-67 percentage,Cerb2 positivity,number of positive lymph nodes,and presence of lymphovascular invasion were examined histopathologically.RESULTS The study included 246 patients with breast cancer:196 were in the normal glucose group and 50 were in the elevated glucose group.In the normal glucose group,68%of the tumors were left-sided and 32%were right-sided,while all tumors in the elevated glucose group were left-sided.This difference was statistically significant(P<0.001).Tumor size,Ki-67,and the number of positive lymph nodes were not associated with blood glucose in patients with breast cancer(P>0.05 for all).However,blood glucose was correlated with age in this population.Correlation analyses revealed that blood glucose was positively correlated with age(r=0.23,P<0.001).Additionally,Ki-67 was correlated with tumor size(r=0.14,P=0.03)and age(r=-0.18,P=0.005).CONCLUSION Our study highlighted the complex interplay between metabolic factors,such as fasting glucose levels,and breast cancer characteristics.Elevated glucose levels were associated with older age.The significant association between tumor laterality and glucose levels underscores the need for further investigation into the collective influence of metabolic and anatomical factors on breast cancer development and progression.展开更多
Background With the rapid growth of internet usage,adolescent cyberbullying has become a pressing issue.This study examines the longitudinal impact of leisure-time physical activity and peer relationships on cyberbull...Background With the rapid growth of internet usage,adolescent cyberbullying has become a pressing issue.This study examines the longitudinal impact of leisure-time physical activity and peer relationships on cyberbullying over a one-year period,drawing on the Stage-Environment Fit Theory and the Interpersonal Relationship Theory.Methods A three-wave longitudinal study was conducted over one year,involving 896 middle school students from five schools in Sichuan,Jiangsu,and Guangdong,China,selected to ensure regional diversity.Participants were recruited using stratified random sampling,and data were collected at four-month intervals.Leisure-time physical activity,peer relationships,and cyberbullying behaviors were assessed using validated scales.Data were analyzed using latent growth modeling(LGM)and structural equation modeling(SEM)to examine longitudinal effects and mediation relationships.Results(1)Leisure-time physical activity,peer relationships,and cyberbullying behaviors remained relatively stable over time.(2)Both leisure-time physical activity and peer relationships significantly reduced future cyberbullying incidents,with physical activity also enhancing subsequent peer relationships.(3)Peer relationships partially mediated the effect of leisure-time physical activity on cyberbullying,indicating that improved peer interactions contributed to a reduction in cyberbullying behaviors.Conclusion This study found that leisure-time sports activities and peer relationships are important factors affecting cyberbullying,and peer relationships play a partial mediating role in it.The results provide empirical support for understanding the formation mechanism and influencing factors of cyberbullying.展开更多
This paper explored how the work hardening process enhances the yield strength(YS)of magnesium alloy and established a novel quantitative relationship between microstructure and YS.The YS of an extruded Mg–Nd–Zn–Zr...This paper explored how the work hardening process enhances the yield strength(YS)of magnesium alloy and established a novel quantitative relationship between microstructure and YS.The YS of an extruded Mg–Nd–Zn–Zr alloy was nearly tripled by rotary swaging at 200℃,attributing to dislocation accumulation,grain fragmentation,and basal texture formation.A modified Hall–Petch relationship(GM–HP)was established by introducing the equivalent orientation factor and dislocation density to accurately quantify the YS and the contribution of each strengthening mechanism.The contributions of dislocation hardening and grain boundary strengthening were multiplied by the strong basal texture.This paper offered valuable insights and guidance for designing and optimizing high-strength wrought magnesium alloys and their plastic processing methods.展开更多
With the rapid development of artificial intelligence(AI)technology,its application in higher education has gradually shifted from traditional teaching aids to deeper levels of interactive learning and emotional conne...With the rapid development of artificial intelligence(AI)technology,its application in higher education has gradually shifted from traditional teaching aids to deeper levels of interactive learning and emotional connection support.AI can enhance teaching efficiency,personalized learning,and real-time feedback;however,in areas such as emotional communication and teacher-student interaction,AI still cannot fully replace the role of teachers.This study aims to explore the transformation of teacher-student relationships in the era of AI,analyze the impact of AI technology on teaching interaction,emotional support,and teacher-student trust,and propose strategies to address these challenges.The research findings indicate that while AI has significant advantages in improving educational efficiency,it has limitations in interpersonal emotional support and the transformation of the teacher’s role.To ensure the comprehensiveness and humanization of education,educators should strengthen emotional care and improve students’emotional literacy in the use of AI,and implement transparent data management and privacy protection measures to enhance teacher-student trust.The study also suggests that by enhancing teacher-student trust,strengthening emotional support,and increasing transparency,educators can effectively address the challenges of teacher-student relationships in the AI era.This research provides theoretical support and practical guidance for the integration of AI technology with educational humanistic care,promoting more comprehensive,personalized,and humane educational development.展开更多
Digital sculpture is the product of the cross-integration of art and technology,and its development is accompanied by the two-way interaction between technological innovation and artistic concepts.Based on this,this p...Digital sculpture is the product of the cross-integration of art and technology,and its development is accompanied by the two-way interaction between technological innovation and artistic concepts.Based on this,this paper mainly analyzes the remolding of artistic creation logic by technical tools and the expansion of technical application boundary by artistic expression,and further reveals the dynamic balance relationship between the two in symbiosis,hoping to help understand the accompanying mechanism of art and technology in the digital age.展开更多
基金supported by the Shanghai Sailing Program,China(Grant No.:23YF1413300).
文摘Quantitative structure-retention relationship(QSRR)is an important tool in chromatography.QSRR examines the correlation between molecular structures and their retention behaviors during chromatographic separation.This approach involves developing models for predicting the retention time(RT)of analytes,thereby accelerating method development and facilitating compound identification.In addition,QSRR can be used to study compound retention mechanisms and support drug screening efforts.This review provides a comprehensive analysis of QSRR workflows and applications,with a special focus on the role of artificial intelligence-an area not thoroughly explored in previous reviews.Moreover,we discuss current limitations in RT prediction and propose promising solutions.Overall,this review offers a fresh perspective on future QSRR research,encouraging the development of innovative strategies that enable the diverse applications of QSRR models in chromatographic analysis.
文摘By investigating the types of 371 non-English major freshmen's use of mother-tongue-reliance strategies in English languagelearning,the study showed that students' use of mother-tongue-reliance strategies would vary significantly with their different L2 profi-ciency.And it was negatively correlated with L2 proficiency.And the study discussed the implications to guide English language teach-ing and learning.
文摘The increasing use of diesel-powered equipment in confined spaces(underground mines) has the potential to over expose underground miners under the threat of diesel particulate matter(DPM). Miners in underground mines can be exposed to DPM concentrations far more than works in other industries. A great number of animal and epidemiological studies have shown that both short-term and long-term DPM exposure have adverse health effect. Based on reviews of related studies, especially some recent evidence, this paper investigated the long and short-term health effects based on animal studies and epidemiological studies. The exposure-response relationship studies were also explored and compared to the current DPM regulation or standards in some countries. This paper found that the DPM health effect studies specifically for miners are not sufficient to draw solid conclusions, and a recommendation limit of DPM concentration can be put in place for better protection of miners from DPM health risk. Current animal studies lack the use of species that have similar lung functions as human for understanding the cancer mode of action in human. And finally, the DPM health hazard will continue to be a challenging topic before the mode of action and reliable exposure-response relationship are established.
基金Supported by Shanghai Education Committee Project (No. 11YZ224)Shanghai Leading Academic Discipline Project (No. J51503)
文摘In the present study,（QSRR） study had been carried out for volatile components from Rosa banksiae Ait.based on various quantum-chemical and physicochemical descriptors derived by B3LYP method.To build QSRR models,a multiple linear regression （MLR） stepwise method was used.The generated models have good predictive ability and are of high statistical significance with good correlation coefficients （R2≥0.734） and p values far less than 0.05.Preliminary results indicated that the application of the models,especially the prediction of GC retention time and linear retention index of volatile components from Rosa banksiae Ait.,will be helpful.The models contribute also to the identification of important quantum-chemical and physicochemical descriptors responsible for the retention time and linear retention index.It was found that the shape attribute （ShpA） and logP value play a vital role in determining component’s GC retention time and linear retention index which increase with the lipophilicity of volatile components.The larger the shape attribute of analyte is,the larger the deformability is,the stronger the interaction between analyte and stationary phase is,and the longer the GC retention time is,the larger the linear retention index is.The importance of E HOMO,q＋,and SEV is also embodied in models,but they are not dominant.
基金supported by the Foundation of Returned Scholars (Main Program) of Shanxi Province (200902)
文摘Polychlorinated dibenzothiophenes（PCDTs） are classified as persistent organic pollutants in the environment,so the analysis of PCDTs by their gas chromatographic behaviors is of great significance.Quantitative structure-retention relationship（QSRR） analysis is a useful technique capable of relating chromatographic retention time to the molecular structure.In this paper,a QSRR study of 37 PCDTs was carried out by using molecular electronegativity distance vector（MEDV） descriptors and multiple linear regression（MLR） and partial least-squares regression（PLS） methods.The correlation coefficient R of established MLR,PLS models,leave-one-out（LOO） cross-validation（CV）,Q2ext were 0.9951,0.9942,0.9839（MLR） and 0.9925,0.9915,0.9833（PLS）,respectively.Results showed that the model exhibited excellent estimate capability for internal sample set and good predictive capability for external sample set.By using MEDV descriptors,the QSRR model can provide a simple and rapid way to predict the gas-chromatographic retention indices of polychlorinated dibenzothiophenes in conditions of lacking standard samples or poor experimental conditions.
文摘BACKGROUND The epidemiological and clinical characteristics of coronavirus disease 2019(COVID-19)patients have been widely reported,but the assessment of doseresponse relationships and risk factors for mortality and severe cases and clinical outcomes remain unclear.AIM To determine the dose-response relationship between risk factors and incidence of COVID-19.METHODS In this retrospective,multicenter cohort study,we included patients with confirmed COVID-19 infection who had been discharged or had died by February 6,2020.We used multivariable logistic regression and Cox proportional hazard models to determine the dose-response relationship between risk factors and incidence of COVID-19.RESULTS It clarified that increasing risk of in-hospital death were associated with older age(HR:1.04,95%CI:1.01-1.09),higher lactate dehydrogenase[HR:1.04,95%confidence interval(CI):1.01-1.10],C-reactive protein(HR:1.10,95%CI:1.01-1.23),and procalcitonin(natural log-transformed HR:1.88,95%CI:1.22-2.88),and D-dimer greater than 1μg/m L at admission(natural log transformed HR:1.63,95%CI:1.03-2.58)by multivariable regression.D-dimer and procalcitonin were logarithmically correlated with COVID-19 mortality risk,while there was a linear dose-response correlation between age,lactate dehydrogenase,D-dimer and procalcitonin,independent of established risk factors.CONCLUSION Higher lactate dehydrogenase,D-dimer,and procalcitonin levels were independently associated with a dose-response increased risk of COVID-19 mortality.
文摘In the international shipping industry, digital intelligence transformation has become essential, with both governments and enterprises actively working to integrate diverse datasets. The domain of maritime and shipping is characterized by a vast array of document types, filled with complex, large-scale, and often chaotic knowledge and relationships. Effectively managing these documents is crucial for developing a Large Language Model (LLM) in the maritime domain, enabling practitioners to access and leverage valuable information. A Knowledge Graph (KG) offers a state-of-the-art solution for enhancing knowledge retrieval, providing more accurate responses and enabling context-aware reasoning. This paper presents a framework for utilizing maritime and shipping documents to construct a knowledge graph using GraphRAG, a hybrid tool combining graph-based retrieval and generation capabilities. The extraction of entities and relationships from these documents and the KG construction process are detailed. Furthermore, the KG is integrated with an LLM to develop a Q&A system, demonstrating that the system significantly improves answer accuracy compared to traditional LLMs. Additionally, the KG construction process is up to 50% faster than conventional LLM-based approaches, underscoring the efficiency of our method. This study provides a promising approach to digital intelligence in shipping, advancing knowledge accessibility and decision-making.
文摘The dose-response relationship for asbestos exposure in a chrysotile product factory was studied. The past gravimetric dust concentration values, obtained from different worksites, were converted into fiber concentration values according to conversion factors that were worked out by simultaneous sampling in this study. The conversions were made so that exposure could be expressed in fiber-years (f-yr). Asbestosis was diagnosed on the basis of chest radiographs and occupational histories. Cumulative dust exposure (f-yr) was calculated up to the date of diagnosis for asbestosis patients, and up to September 1982 for the remaining workers. A dose-response relationship expressed as fiber-years exposed vs cumulative prevalence of asbestosis was established by the life table method on the basis of these data. Predicted 3 and 1% prevalence of asbestosis corresponded to 43 and 22 f-yr exposure, respectively. Considering that a worker can work for 35 years, these doses are commensurate with dust concentrations of 1.22 and 0.63 f/ml, respectively. It is recommended that 1 f/ml be taken as the maximum allowable concentration of airborne asbestos dust for the workplace with an anticipated prevalence of about 2% asbestosis after 35 years of exposure. 1990 Academic Press, Inc.
文摘In this editorial,I comment on the article by Zhang et al.To emphasize the importance of the topic,I discuss the relationship between the use of smart medical devices and mental health.Smart medical services have the potential to positively influence mental health by providing monitoring,insights,and inter-ventions.However,they also come with challenges that need to be addressed.Understanding the primary purpose for which individuals use these smart tech-nologies is essential to tailoring them to specific mental health needs and prefe-rences.
文摘This study investigated the role of intentional self-regulation and the moderating role of peer relationship in the relationship between teacher-student relationship and learning engagement.The study sample comprised 540 Chinese senior secondary school students between the ages of 15–18(51.67%boys;Mage=16.56 years;SDage=0.90).They completed surveys on the Teacher-Student Relationship Scale,the Selection,Optimization,and Compensation(SOC)Scale,the Peer Relationship Scale for Children and Adolescents,and the Learning Engagement Scale.The results following regression analysis showed that teacher-student relationship predicted higher learning engagement among senior secondary school students.Intentional self-regulation partially mediated the link between teacher-student relationship and learning engagement for higher learning engagement.Peer relationship moderated the relationships between teacher-student relationship and learning engagement and moderated the relationship between teacher-student relationship and intentional self-regulation for higher learning engagement.Thesefindings imply learning engagement can be enhanced by optimizing teacher-student relationship and strengthening intentional self-regulation interventions.
基金supported by the Fundamental Research Funds for the Central Universities(Grant No.B240201068)the National Natural Science Foundation of China(Grant No.42361144861)the National Basic Research Program of China(Grant No.2014CB954303).
文摘The relationship between ecosystem services(ES)and human well-being(HWB)is fundamental to the science and practice of sustainability.However,studies have shown conflicting results,which has been attributed to the influences of indicators,contexts,and scales.Yet,another potential factor,which has been overlooked,may be the mixed use of spatial and temporal approaches.Using twelve ES and seven well-being indicators and multiple statistical methods,we quantified and compared the spatial and temporal ES–HWB relationships for Inner Mongolia,China.The spatial and temporal relationships differed in both correlation direction and strength.Most relationships of economic and employment-related indicators with food provisioning and supporting services were temporally positive but spatially nonsignificant or negative.Some relationships of economic and employmentrelated indicators with water retention,sandstorm prevention,and wind erosion were temporally negative but spatially complex.However,the spatial and temporal ES–HWB relationships could also be similar in some cases.We conclude that although both the spatial and temporal approaches have merits,space generally cannot substitute for time in the study of ES–HWB relationship.Our study helps reconcile the seemingly conflicting findings in the literature,and suggests that future studies should explicitly distinguish between the spatial and temporal ES–HWB relationships.
基金supported by the 2024 Henan Province Philosophy and Social Science Planning Project(Youth Project)entitled“Research on the Mechanism and Intervention of Self-Regulated Learning in Promoting Children’s Chinese Reading Comprehension”(2024CJY070).
文摘This study examined the impact of teacher-student relationship quality on students’risk of bullying victimiza-tion and the mediating roles of student-student relationships and student engagement in this relationship.A total of 656 Chinese junior high school students(females=361,mean age=13.75,SD=0.98)completed validated measures of teacher-student relationship quality,student-student relationship quality,student engagement,and bullying victimization.Regression analysis results indicated that higher teacher-student relationship quality predicted a lower risk of student bullying victimization.Serial mediating effect testing of the student-student relationship quality and student engagement revealed that these factors fully mediated the relationship between teacher-student relationship quality and bullying victimization,resulting in a lower risk of bullying victimization.The results showed that student-student relationship quality had a more substantial mediating effect than student engagement.Thefindings support the Socio-Ecological Framework,suggesting that within the Microsystem,interactions between individuals and their immediate environments significantly impact their behavior.Specifically,thesefindings suggest that good teacher-student relationships can enhance the quality of student-student relationships and student engagement,thereby preventing and reducing the occurrence of bullying victimization.
基金supported by National Key R&D Program of China(2022YFF1100300)Joint Fund of Henan Province Science and Technology R&D Program(235200810051)+1 种基金Key Project in Science and Technology Agency of Henan Province(242102310561)key research projects of higher education institutions in Henan Province(24B350002).
文摘Soybean is widely used in diets,and numerous reports have highlighted its antioxidant properties.However,constructing a methodology for rapid identifying and predicting a series of antioxidant active ingredients in Soybean presents certain challenges.Therefore,we introduced the spectrum-effect relationship-ingredient knockout identification technique to identify a series of antioxidant active ingredients in soybean.By combining untargeted metabolomics with network pharmacology,we predicted the antioxidant active ingredients and their target sites.We successfully identified 4 antioxidant active compounds(daidzein,genistein,daidzein,and glycitin)and 10 corresponding antioxidant targets(epidermal growth factor receptor(EGFR),estrogen receptor 1(ESR1),steroid receptor coactivator(SRC),tumor necrosis factor(TNF),kinase insert domain receptor(KDR),AKT serine/threonine kinase 1(AKT1),growth factor receptor bound protein 2(GRB2),signal transducer and activator of transcription1(STAT1),mitogen-activated protein kinase 8(MAPK8),B-cell lymphoma-2(BCL2))by our analysis.The validation results from cell experiments revealed that glycitin exhibited the best antioxidant activity and significantly influenced the expression of EGFR and the proteins associated with nuclear factor erythroid 2-related factor 2/NAD(P)H quinone dehydrogenase 1(NRF2/NQO1)signaling pathways.These findings were consistent with the predicted outcomes and were further confirmed in a zebrafish model.It suggests that glycitin may exert antioxidant effects by regulating the expression of EGFR,NRF2,and NQO1 proteins.The results demonstrate that a rapid analytical method for determining antioxidant activity was established.
文摘Since China’s reform and development,under the influence of the global religious and cultural boom,it has also focused on studying Islamic culture and related fields,resulting in many important representative works.The main characteristic of writing books in this area is to use popular knowledge materials that are suitable for various sectors of society.There are also works exploring the historical evolution of Islamic culture in China,which involve the relationship between Islamic culture and traditional Chinese culture.Before the 1980s,there were no significant achievements in publishing papers.However,since the 1990s,there has been a noticeable increase in papers related to Islamic culture and related fields,with new advances in research areas and methods.There are both articles that explore the attributes and characteristics of Islamic culture from the perspectives of world history and culture,as well as many articles that explore various specific aspects of Islamic culture from the perspective of specific topics.In this article,the author collects academic achievements in the study of Islamic culture in China and introduces them to the academic community,letting them know about China's research on world Islamic culture.
文摘BACKGROUND Hyperglycemia secondary to diabetes can lead to organ failure unless properly controlled,and it is associated with numerous health issues,particularly metabolic problems.Breast cancer is one of the most common malignancies in females worldwide and represents a major health concern due to its morbidity and mortality.The progression of the disease and the response to treatment depend on numerous variables,including both tumor biology and patient-related factors.Key prognostic indicators include age,tumor size,lymph node involvement,histological type,hormone receptor status,and expression of biomarkers such as HER2.AIM To investigate the relationship between preoperative blood glucose levels and cancer prognostic factors in patients diagnosed with breast cancer.METHODS In this study patients diagnosed with breast cancer were classified into two groups:Those with blood glucose levels<125 mg/dL and those with levels>125 mg/dL.Estrogen and progesterone receptor positivity,Ki-67 percentage,Cerb2 positivity,number of positive lymph nodes,and presence of lymphovascular invasion were examined histopathologically.RESULTS The study included 246 patients with breast cancer:196 were in the normal glucose group and 50 were in the elevated glucose group.In the normal glucose group,68%of the tumors were left-sided and 32%were right-sided,while all tumors in the elevated glucose group were left-sided.This difference was statistically significant(P<0.001).Tumor size,Ki-67,and the number of positive lymph nodes were not associated with blood glucose in patients with breast cancer(P>0.05 for all).However,blood glucose was correlated with age in this population.Correlation analyses revealed that blood glucose was positively correlated with age(r=0.23,P<0.001).Additionally,Ki-67 was correlated with tumor size(r=0.14,P=0.03)and age(r=-0.18,P=0.005).CONCLUSION Our study highlighted the complex interplay between metabolic factors,such as fasting glucose levels,and breast cancer characteristics.Elevated glucose levels were associated with older age.The significant association between tumor laterality and glucose levels underscores the need for further investigation into the collective influence of metabolic and anatomical factors on breast cancer development and progression.
基金funded by the following projects:National Social Science Fund Project“The Empowerment Mechanism of Physical Exercise on Emotional Regulation in Adolescents”(23BTY116)Leshan Normal University 2024 Research Cultivation Project:“Research on the Trajectory Effect of Family Cumulative Risk and Home-based Activity of Adolescents”(KYPY2025-0014)+1 种基金Key Humanities and Social Sciences Cultivation Project of Leshan Normal University:“Research on the Sequence Difference of Knowledge and Behavior of Physical Activity among Adolescents and the Compensation Mechanism”and Sichuan Province College Students’Sports Association Annual Project“The Trajectory Effect of Family Cumulative Risk and Adolescents’Home Physical Activity”(23CDTXQ004).
文摘Background With the rapid growth of internet usage,adolescent cyberbullying has become a pressing issue.This study examines the longitudinal impact of leisure-time physical activity and peer relationships on cyberbullying over a one-year period,drawing on the Stage-Environment Fit Theory and the Interpersonal Relationship Theory.Methods A three-wave longitudinal study was conducted over one year,involving 896 middle school students from five schools in Sichuan,Jiangsu,and Guangdong,China,selected to ensure regional diversity.Participants were recruited using stratified random sampling,and data were collected at four-month intervals.Leisure-time physical activity,peer relationships,and cyberbullying behaviors were assessed using validated scales.Data were analyzed using latent growth modeling(LGM)and structural equation modeling(SEM)to examine longitudinal effects and mediation relationships.Results(1)Leisure-time physical activity,peer relationships,and cyberbullying behaviors remained relatively stable over time.(2)Both leisure-time physical activity and peer relationships significantly reduced future cyberbullying incidents,with physical activity also enhancing subsequent peer relationships.(3)Peer relationships partially mediated the effect of leisure-time physical activity on cyberbullying,indicating that improved peer interactions contributed to a reduction in cyberbullying behaviors.Conclusion This study found that leisure-time sports activities and peer relationships are important factors affecting cyberbullying,and peer relationships play a partial mediating role in it.The results provide empirical support for understanding the formation mechanism and influencing factors of cyberbullying.
基金supported by National Natural Science Foundation of China(Grant No.51975146)Natural Science Foundation of Shandong Province(Grant No.ZR2020QE171)。
文摘This paper explored how the work hardening process enhances the yield strength(YS)of magnesium alloy and established a novel quantitative relationship between microstructure and YS.The YS of an extruded Mg–Nd–Zn–Zr alloy was nearly tripled by rotary swaging at 200℃,attributing to dislocation accumulation,grain fragmentation,and basal texture formation.A modified Hall–Petch relationship(GM–HP)was established by introducing the equivalent orientation factor and dislocation density to accurately quantify the YS and the contribution of each strengthening mechanism.The contributions of dislocation hardening and grain boundary strengthening were multiplied by the strong basal texture.This paper offered valuable insights and guidance for designing and optimizing high-strength wrought magnesium alloys and their plastic processing methods.
基金The 2024 Higher Education Teaching Reform Project of Guangdong University of Science and Technology,“Teaching Practice of Human Resource Management Course Based on SPOC+FC Hybrid Teaching Mode”(GKZLGC2024024)。
文摘With the rapid development of artificial intelligence(AI)technology,its application in higher education has gradually shifted from traditional teaching aids to deeper levels of interactive learning and emotional connection support.AI can enhance teaching efficiency,personalized learning,and real-time feedback;however,in areas such as emotional communication and teacher-student interaction,AI still cannot fully replace the role of teachers.This study aims to explore the transformation of teacher-student relationships in the era of AI,analyze the impact of AI technology on teaching interaction,emotional support,and teacher-student trust,and propose strategies to address these challenges.The research findings indicate that while AI has significant advantages in improving educational efficiency,it has limitations in interpersonal emotional support and the transformation of the teacher’s role.To ensure the comprehensiveness and humanization of education,educators should strengthen emotional care and improve students’emotional literacy in the use of AI,and implement transparent data management and privacy protection measures to enhance teacher-student trust.The study also suggests that by enhancing teacher-student trust,strengthening emotional support,and increasing transparency,educators can effectively address the challenges of teacher-student relationships in the AI era.This research provides theoretical support and practical guidance for the integration of AI technology with educational humanistic care,promoting more comprehensive,personalized,and humane educational development.
文摘Digital sculpture is the product of the cross-integration of art and technology,and its development is accompanied by the two-way interaction between technological innovation and artistic concepts.Based on this,this paper mainly analyzes the remolding of artistic creation logic by technical tools and the expansion of technical application boundary by artistic expression,and further reveals the dynamic balance relationship between the two in symbiosis,hoping to help understand the accompanying mechanism of art and technology in the digital age.
