We analyzed the efficacy of penile low-intensity extracorporeal shockwave treatment for erectile dysfunction(ED)combined with cavernous artery disease(CAD).ED was evaluated by the International Index of Erectile Funct...We analyzed the efficacy of penile low-intensity extracorporeal shockwave treatment for erectile dysfunction(ED)combined with cavernous artery disease(CAD).ED was evaluated by the International Index of Erectile Function,subdividing patients into mild and moderate/severe forms.CAD was assessed using penile color Doppler ultrasonography.Patients(n=111)with a positive outcome after treatment,based upon the minimal clinically important difference of the International Index of ED,were followed up for 3 months and 6 months.We found a significant mean increase in the index of erectile function,with an overall improvement in hemodynamic parameters of the cavernous artery.In particular,93.9%of the patients with mild ED without CAD responded to treatment and 72.7%resumed normal erectile function.Only 31.2%of the patients with moderate/severe ED and CAD responded to treatment,and none resumed normal erectile function.All patients with mild ED and no CAD maintained the effects of therapy after 3 months,while no patients with moderate/severe ED and CAD maintained the benefits of treatment after 3 months.Thus,patients with mild ED and no CAD have better and longer lasting responses to such treatment,with a higher probability of resuming normal erectile function than patients with moderate/severe ED and CAD.展开更多
Erectile dysfunction （ED） is a common disorder among aging males. However, most aging males refuse to seek medical help and believe that ED is an irreversible event in the aging process. The purpose of this study wa...Erectile dysfunction （ED） is a common disorder among aging males. However, most aging males refuse to seek medical help and believe that ED is an irreversible event in the aging process. The purpose of this study was to describe the current medical management of ED in aging males and to examine whether it is too late to treat this disorder in these elderly men. From 2007 to 2008, 4507 patients diagnosed with ED were gathered from 46 centers in China; 4241 completed the study, 3837 of whom were treated with sildenafil. The 3837 patients were divided into five groups based on age （group A： 20-30 years; group B： 31-40 years; group C： 41-50 years; group D： 51-60 years; and group E： 〉60 years）. After comparing pre- and posttreatment International Index of Erectile Function-Erectile Function domain （IIEF-EF） questionnaires, Erection Hardness Scale （EHS）, and IIEF Q13 （＂How satisfied have you been with your overall sex life？＂）, we discovered that the aging males had worse erectile function, erection hardness, and sexual satisfaction than the younger males （P〈 0.001）. After treatment, the improvement rates in the IIEF-EF, EHS, and IIEF Q13 scores were 107.0%, 83.1%, and 116.5%, respectively. The magnitude of these changes demonstrated significant differences among groups （P 〈 0.001）. Accordingly, aging males are likely to benefit more from medical treatment. We propose that aging males should be informed that age is not a limiting factor for medical ED management, and it is never too late to treat.展开更多
Purpose:To elucidate the impact of mild posterior capsule opacification(PCO)on the visual outcomes in patients with hydrophilic trifocal intraocular lens(IOLs),and to identify objective indicators that can assist in d...Purpose:To elucidate the impact of mild posterior capsule opacification(PCO)on the visual outcomes in patients with hydrophilic trifocal intraocular lens(IOLs),and to identify objective indicators that can assist in determining the need for neodymium:yttrium-aluminum-garnet(Nd:YAG)laser capsulotomy.Methods:This is a prospective observational study.189 patients implanted trifocal IOLs who underwent Nd:YAG laser posterior capsulotomy were recruited.Patients were classified into four grades according to PCO morphology.The distance,intermediate,and near visual acuity(VA),dysfunction lens index(DLI),contrast sensitivity(CS)and visual function(VF-14)scores were measured before and 1 month after Nd:YAG laser capsulotomy.Results:Before Nd:YAG laser capsulotomy,a significant correlation was observed between PCO grading and uncorrected distance VA(UDVA),uncorrected intermediate VA(UIVA),uncorrected near VA(UNVA)visual acuity,corrected distance VA(CDVA),DLI,and VF-14 scores(All P<0.001).However,in patients with PCO grade 1(mild),post-capsulotomy UNVA,DLI,medium and high spatial frequency CS under photopic condition and VF-14 scores were significantly improved compared with pre-capsulotomy values(all P<0.05).The area under the receiver operating characteristic curve for DLI was 0.830(P<0.001),with a corresponding cut-off value of 7.225,indicating its usefulness in assessing the need for Nd:YAG laser capsulotomy in cases of mild PCO.Conclusions:Mild PCO initially impairs near visual acuity in patients with trifocal IOLs and concurrently diminishes both subjective and objective of visual quality.The DLI can serve as an auxiliary diagnostic indicator to assess whether patients with mild PCO may benefit from Nd:YAG laser capsulotomy.展开更多
文摘We analyzed the efficacy of penile low-intensity extracorporeal shockwave treatment for erectile dysfunction(ED)combined with cavernous artery disease(CAD).ED was evaluated by the International Index of Erectile Function,subdividing patients into mild and moderate/severe forms.CAD was assessed using penile color Doppler ultrasonography.Patients(n=111)with a positive outcome after treatment,based upon the minimal clinically important difference of the International Index of ED,were followed up for 3 months and 6 months.We found a significant mean increase in the index of erectile function,with an overall improvement in hemodynamic parameters of the cavernous artery.In particular,93.9%of the patients with mild ED without CAD responded to treatment and 72.7%resumed normal erectile function.Only 31.2%of the patients with moderate/severe ED and CAD responded to treatment,and none resumed normal erectile function.All patients with mild ED and no CAD maintained the effects of therapy after 3 months,while no patients with moderate/severe ED and CAD maintained the benefits of treatment after 3 months.Thus,patients with mild ED and no CAD have better and longer lasting responses to such treatment,with a higher probability of resuming normal erectile function than patients with moderate/severe ED and CAD.
文摘Erectile dysfunction （ED） is a common disorder among aging males. However, most aging males refuse to seek medical help and believe that ED is an irreversible event in the aging process. The purpose of this study was to describe the current medical management of ED in aging males and to examine whether it is too late to treat this disorder in these elderly men. From 2007 to 2008, 4507 patients diagnosed with ED were gathered from 46 centers in China; 4241 completed the study, 3837 of whom were treated with sildenafil. The 3837 patients were divided into five groups based on age （group A： 20-30 years; group B： 31-40 years; group C： 41-50 years; group D： 51-60 years; and group E： 〉60 years）. After comparing pre- and posttreatment International Index of Erectile Function-Erectile Function domain （IIEF-EF） questionnaires, Erection Hardness Scale （EHS）, and IIEF Q13 （＂How satisfied have you been with your overall sex life？＂）, we discovered that the aging males had worse erectile function, erection hardness, and sexual satisfaction than the younger males （P〈 0.001）. After treatment, the improvement rates in the IIEF-EF, EHS, and IIEF Q13 scores were 107.0%, 83.1%, and 116.5%, respectively. The magnitude of these changes demonstrated significant differences among groups （P 〈 0.001）. Accordingly, aging males are likely to benefit more from medical treatment. We propose that aging males should be informed that age is not a limiting factor for medical ED management, and it is never too late to treat.
基金funded by the Chinese National Nature Science Foundation,grant number 82171039.
文摘Purpose:To elucidate the impact of mild posterior capsule opacification(PCO)on the visual outcomes in patients with hydrophilic trifocal intraocular lens(IOLs),and to identify objective indicators that can assist in determining the need for neodymium:yttrium-aluminum-garnet(Nd:YAG)laser capsulotomy.Methods:This is a prospective observational study.189 patients implanted trifocal IOLs who underwent Nd:YAG laser posterior capsulotomy were recruited.Patients were classified into four grades according to PCO morphology.The distance,intermediate,and near visual acuity(VA),dysfunction lens index(DLI),contrast sensitivity(CS)and visual function(VF-14)scores were measured before and 1 month after Nd:YAG laser capsulotomy.Results:Before Nd:YAG laser capsulotomy,a significant correlation was observed between PCO grading and uncorrected distance VA(UDVA),uncorrected intermediate VA(UIVA),uncorrected near VA(UNVA)visual acuity,corrected distance VA(CDVA),DLI,and VF-14 scores(All P<0.001).However,in patients with PCO grade 1(mild),post-capsulotomy UNVA,DLI,medium and high spatial frequency CS under photopic condition and VF-14 scores were significantly improved compared with pre-capsulotomy values(all P<0.05).The area under the receiver operating characteristic curve for DLI was 0.830(P<0.001),with a corresponding cut-off value of 7.225,indicating its usefulness in assessing the need for Nd:YAG laser capsulotomy in cases of mild PCO.Conclusions:Mild PCO initially impairs near visual acuity in patients with trifocal IOLs and concurrently diminishes both subjective and objective of visual quality.The DLI can serve as an auxiliary diagnostic indicator to assess whether patients with mild PCO may benefit from Nd:YAG laser capsulotomy.
