Objective:To study the correlation between CT dynamic enhanced scanning parameters and serum tumor markers before and after radiofrequency ablation in patients with lung cancer.Methods:60 patients with advanced non-sm...Objective:To study the correlation between CT dynamic enhanced scanning parameters and serum tumor markers before and after radiofrequency ablation in patients with lung cancer.Methods:60 patients with advanced non-small cell lung cancer who were treated in this hospital between January 2015 and January 2017 were divided into control group(n=30)and observation group(n=30)by random number table method.Control group received conventional intravenous chemotherapy,and observation group received intravenous chemotherapy combined with radiofrequency ablation.The differences in CT dynamic enhanced scanning parameter levels and serum tumor marker contents were compared between the two groups of patients before and after treatment.Pearson test was used to evaluate the correlation between CT dynamic enhanced scanning parameters and serum tumor marker contents in patients with advanced non-small cell lung cancer.Results:Before treatment,the differences in CT dynamic enhanced scanning parameter levels,non-organ-specific tumor marker contents and vascular tumor marker contents were not statistically significant between the two groups of patients(P>0.05).After treatment,CT dynamic enhanced scanning parameters PH and perfusion value levels of observation group were lower than those of control group(P<0.05);serum non-organ specific tumor markers CA125,CA153,CEA and CYFRA21-1 contents of observation group were lower than those of control group;serum vascular tumor markers VEGF,Ang-2,HIF-1 and MMP-9 contents were lower than those of control group(P<0.05).Pearson test showed that CT dynamic enhanced scanning parameters PH and perfusion value levels in patients with non-small cell lung cancer were positively correlated with serum non-organ specific tumor marker and vascular tumor marker contents.Conclusion:Adjuvant radiofrequency ablation can significantly reduce the tumor malignancy of patients with advanced non-small cell lung cancer.展开更多
Insulinomas are the most common category of pancreatic endocrine tumors,with an annual incidence of 1-4 cases per million people.Most are intrapancreatic,benign and solitary.Therefore,they have an excellent prognosis ...Insulinomas are the most common category of pancreatic endocrine tumors,with an annual incidence of 1-4 cases per million people.Most are intrapancreatic,benign and solitary.Therefore,they have an excellent prognosis after surgical resection.However,the localization diagnosis of insulinomas still poses a challenge to surgeons and radiologists.In this case,the tumor was occult and could not be found by either abdominal enhanced spiral computed tomography(CT)or ultrasonography.Therefore,we tried a new method of CT scanning and localized the tumor.展开更多
Objective: to analyze the role of dynamic magnetic resonance enhancement in imaging diagnosis of early hepatocellular carcinoma. Methods: sixty-two patients with hepatocytic lesions who were enrolled in our hospital f...Objective: to analyze the role of dynamic magnetic resonance enhancement in imaging diagnosis of early hepatocellular carcinoma. Methods: sixty-two patients with hepatocytic lesions who were enrolled in our hospital from June 2019 to June 2020 were selected as the research subjects. All patients were examined by dynamic enhanced CT scan and liver MRI. The diagnostic results of the two different methods were analyzed based on pathological examination, and their diagnostic value was compared. Conclusion: liver MRI examination in patients with HCC has relatively high sensitivity and specificity, and excellent application effect, which can provide accurate basis for early diagnosis and later targeted treatment by doctors, and is worthy of clinical application and vigorous promotion.展开更多
Objective: to study the diagnostic value of solitary pulmonary nodules on dynamic enhancement of CT scan. Methods: the clinical data of 100 patients with solitary pulmonary nodules in our hospital from January 2018 to...Objective: to study the diagnostic value of solitary pulmonary nodules on dynamic enhancement of CT scan. Methods: the clinical data of 100 patients with solitary pulmonary nodules in our hospital from January 2018 to December 2020 were analyzed retrospectively. All patients underwent dynamic enhancement of CT scanning, and the results of pathological examination and CT scanning were compared and analyzed. Results: in the comparison between dynamic enhancement of CT scan and pathological examination, 95.83% were the diagnostic coincidence rate of malignant pulmonary nodules and 93.33% were benign pulmonary nodules. The coincidence rate of benign and malignant pulmonary nodules before and after enhanced scan was significantly lower than that after enhanced scan (P < 0.05);There was significant difference in CT value between benign and malignant pulmonary nodules (P < 0.05). Conclusion: in the differential diagnosis and diagnosis of solitary pulmonary nodules by dynamic contrast-enhanced CT scanning, it is worthy of clinical application and has high application value.展开更多
Background Quantitative dynamic contrast enhancement MR imaging(DCE-MRI),used to measure properties of tissue microvasculature and tumor angiogenesis,is a promising method for distinguishing benign and malignant tumor...Background Quantitative dynamic contrast enhancement MR imaging(DCE-MRI),used to measure properties of tissue microvasculature and tumor angiogenesis,is a promising method for distinguishing benign and malignant tumors and characterizing tumor response to antiangiogenic treatment.The aim of this study was to assess the feasibility of quantitative parameters derived from clinically used DCE-MRI for distinguishing benign from malignant tumors in the sinonasal area,which may be potentially useful for prediction and monitoring of treatment response to chemoradiotherapy of sinonasal tumors.Methods One hundred and forty-three patients with sinonasal tumors,including 78 malignant tumors and 65 benign tumors and tumor-like lesions,underwent clinically used DCE-MRI.Parametric maps were obtained for quantitative parameters including Ktrans,kep and ve.Two radiologists reviewed these maps and measured Ktrans,kep and ve in the tumor tissue.Data were analyzed using independent T-test or Mann-Whitney U test analysis and receiver operating characteristic curves.Results Ktrans,kep and ve showed significant differences between benign and malignant tumors in the sinonasal area(P=-0.0001).The accuracy of Ktrans,kep and ve in differentiation between benign and malignant sinonasal tumors were 72.0%,76.2%and 67.1%,respectively.There were significant differences in kep and ve between malignant epithelial sinonasal tumors and lymphomas(P<0.05).Using a ve value of 0.213 as the threshold value differentiated malignant epithelial tumors from lymphomas with an accuracy of 78.3%,sensitivity of 88.2%,specificity of 68.0%,positive predictive value of 66.7%,and negative predictive value of 90.9%.However,no significant difference in Ktrans and kep was found between malignant epithelial and non-epithelial tumors in the sinonasal area(P>0.05).Conclusions It is feasible that quantitative parameters of tumors can be derived from clinically used DCE-MRI in the sinonasal region.Preliminary findings suggest an increased value for quantitative DCE-MRI in the evaluation of sinonasal tumors in clinical practice.展开更多
基金Health and Family Planning Commission of Zigong(No.2017wZCS09)
文摘Objective:To study the correlation between CT dynamic enhanced scanning parameters and serum tumor markers before and after radiofrequency ablation in patients with lung cancer.Methods:60 patients with advanced non-small cell lung cancer who were treated in this hospital between January 2015 and January 2017 were divided into control group(n=30)and observation group(n=30)by random number table method.Control group received conventional intravenous chemotherapy,and observation group received intravenous chemotherapy combined with radiofrequency ablation.The differences in CT dynamic enhanced scanning parameter levels and serum tumor marker contents were compared between the two groups of patients before and after treatment.Pearson test was used to evaluate the correlation between CT dynamic enhanced scanning parameters and serum tumor marker contents in patients with advanced non-small cell lung cancer.Results:Before treatment,the differences in CT dynamic enhanced scanning parameter levels,non-organ-specific tumor marker contents and vascular tumor marker contents were not statistically significant between the two groups of patients(P>0.05).After treatment,CT dynamic enhanced scanning parameters PH and perfusion value levels of observation group were lower than those of control group(P<0.05);serum non-organ specific tumor markers CA125,CA153,CEA and CYFRA21-1 contents of observation group were lower than those of control group;serum vascular tumor markers VEGF,Ang-2,HIF-1 and MMP-9 contents were lower than those of control group(P<0.05).Pearson test showed that CT dynamic enhanced scanning parameters PH and perfusion value levels in patients with non-small cell lung cancer were positively correlated with serum non-organ specific tumor marker and vascular tumor marker contents.Conclusion:Adjuvant radiofrequency ablation can significantly reduce the tumor malignancy of patients with advanced non-small cell lung cancer.
文摘Insulinomas are the most common category of pancreatic endocrine tumors,with an annual incidence of 1-4 cases per million people.Most are intrapancreatic,benign and solitary.Therefore,they have an excellent prognosis after surgical resection.However,the localization diagnosis of insulinomas still poses a challenge to surgeons and radiologists.In this case,the tumor was occult and could not be found by either abdominal enhanced spiral computed tomography(CT)or ultrasonography.Therefore,we tried a new method of CT scanning and localized the tumor.
文摘Objective: to analyze the role of dynamic magnetic resonance enhancement in imaging diagnosis of early hepatocellular carcinoma. Methods: sixty-two patients with hepatocytic lesions who were enrolled in our hospital from June 2019 to June 2020 were selected as the research subjects. All patients were examined by dynamic enhanced CT scan and liver MRI. The diagnostic results of the two different methods were analyzed based on pathological examination, and their diagnostic value was compared. Conclusion: liver MRI examination in patients with HCC has relatively high sensitivity and specificity, and excellent application effect, which can provide accurate basis for early diagnosis and later targeted treatment by doctors, and is worthy of clinical application and vigorous promotion.
文摘Objective: to study the diagnostic value of solitary pulmonary nodules on dynamic enhancement of CT scan. Methods: the clinical data of 100 patients with solitary pulmonary nodules in our hospital from January 2018 to December 2020 were analyzed retrospectively. All patients underwent dynamic enhancement of CT scanning, and the results of pathological examination and CT scanning were compared and analyzed. Results: in the comparison between dynamic enhancement of CT scan and pathological examination, 95.83% were the diagnostic coincidence rate of malignant pulmonary nodules and 93.33% were benign pulmonary nodules. The coincidence rate of benign and malignant pulmonary nodules before and after enhanced scan was significantly lower than that after enhanced scan (P < 0.05);There was significant difference in CT value between benign and malignant pulmonary nodules (P < 0.05). Conclusion: in the differential diagnosis and diagnosis of solitary pulmonary nodules by dynamic contrast-enhanced CT scanning, it is worthy of clinical application and has high application value.
基金This work was supported by grants from Beijing Excellent Talents Foundation(No.2010D003034000033)Beijing Municipal Natural Science Foundation(No.7112030),High Levels of Health Technical Personnel in Beijing City(No.2011-3-047)China Postdoctoral Science Foundation(No.2011M500026).
文摘Background Quantitative dynamic contrast enhancement MR imaging(DCE-MRI),used to measure properties of tissue microvasculature and tumor angiogenesis,is a promising method for distinguishing benign and malignant tumors and characterizing tumor response to antiangiogenic treatment.The aim of this study was to assess the feasibility of quantitative parameters derived from clinically used DCE-MRI for distinguishing benign from malignant tumors in the sinonasal area,which may be potentially useful for prediction and monitoring of treatment response to chemoradiotherapy of sinonasal tumors.Methods One hundred and forty-three patients with sinonasal tumors,including 78 malignant tumors and 65 benign tumors and tumor-like lesions,underwent clinically used DCE-MRI.Parametric maps were obtained for quantitative parameters including Ktrans,kep and ve.Two radiologists reviewed these maps and measured Ktrans,kep and ve in the tumor tissue.Data were analyzed using independent T-test or Mann-Whitney U test analysis and receiver operating characteristic curves.Results Ktrans,kep and ve showed significant differences between benign and malignant tumors in the sinonasal area(P=-0.0001).The accuracy of Ktrans,kep and ve in differentiation between benign and malignant sinonasal tumors were 72.0%,76.2%and 67.1%,respectively.There were significant differences in kep and ve between malignant epithelial sinonasal tumors and lymphomas(P<0.05).Using a ve value of 0.213 as the threshold value differentiated malignant epithelial tumors from lymphomas with an accuracy of 78.3%,sensitivity of 88.2%,specificity of 68.0%,positive predictive value of 66.7%,and negative predictive value of 90.9%.However,no significant difference in Ktrans and kep was found between malignant epithelial and non-epithelial tumors in the sinonasal area(P>0.05).Conclusions It is feasible that quantitative parameters of tumors can be derived from clinically used DCE-MRI in the sinonasal region.Preliminary findings suggest an increased value for quantitative DCE-MRI in the evaluation of sinonasal tumors in clinical practice.
