BACKGROUND Bile duct stones(BDSs)may cause patients to develop liver cirrhosis or even liver cancer.Currently,the success rate of surgical treatment for intrahepatic and extrahepatic BDSs is not satisfactory,and there...BACKGROUND Bile duct stones(BDSs)may cause patients to develop liver cirrhosis or even liver cancer.Currently,the success rate of surgical treatment for intrahepatic and extrahepatic BDSs is not satisfactory,and there is a risk of postoperative complic-ations.AIM To compare the clinical effects of dual-modality endoscopy(duodenoscopy and laparoscopy)with those of traditional laparotomy in the treatment of intra-and extrahepatic BDSs.METHODS Ninety-five patients with intra-and extrahepatic BDSs who sought medical services at Wuhan No.1 Hospital between August 2019 and May 2023 were selected;45 patients in the control group were treated by traditional laparotomy,and 50 patients in the research group were treated by dual-modality endoscopy.The following factors were collected for analysis:curative effects,safety(incision infection,biliary fistula,lung infection,hemobilia),surgical factors[surgery time,intraoperative blood loss(IBL)volume,gastrointestinal function recovery time,and length of hospital stay],serum inflammatory markers[tumor necrosis factor(TNF)-α,interleukin(IL)-6,and IL-8],and oxidative stress[glutathione peroxidase(GSH-Px),superoxide dismutase(SOD),malondialdehyde(MDA),and advanced protein oxidation products(AOPPs)].RESULTS The analysis revealed markedly better efficacy(an obviously higher total effective rate)in the research group than in the control group.In addition,an evidently lower postoperative complication rate,shorter surgical duration,gastrointestinal function recovery time and hospital stay,and lower IBL volume were observed in the research group.Furthermore,the posttreatment serum inflammatory marker(TNF-α,IL-6,and IL-8)levels were significantly lower in the research group than in the control group.Compared with those in the control group,the posttreatment GSH-Px,SOD,MDA and AOPPs in the research group were equivalent to the pretreatment levels;for example,the GSH-Px and SOD levels were significantly higher,while the MDA and AOPP levels were lower.CONCLUSION Dual-modality endoscopy therapy(duodenoscopy and laparoscopy)is more effective than traditional laparotomy in the treatment of intra-and extrahepatic BDSs and has a lower risk of postoperative complications;significantly shortened surgical time;shorter gastrointestinal function recovery time;shorter hospital stay;and lower intraop-erative bleeding volume,while having a significant inhibitory effect on excessive serum inflammation and causing little postoperative oxidative stress.展开更多
Selective detection of multiple analytes in a compact design with dual-modality and theranostic features presents great challenges. Herein, we wish to report a coumarin-thiazolidine masked D-penicillamine based dual-m...Selective detection of multiple analytes in a compact design with dual-modality and theranostic features presents great challenges. Herein, we wish to report a coumarin-thiazolidine masked D-penicillamine based dual-modality fluorescent probe COU-DPA-1 for selective detection, differentiation, and detoxification of multiple heavy metal ions(Ag^(+), Hg^(2+), Cu^(2+)). The probe shows divergent fluorescence(FL)/circular dichroism(CD) responses via divergent bond-cleavage cascade reactions(metal ion promoted C-S cleavage and hydrolysis at two distinctive cleavage sites): FL “turn-off” and CD “turn-on” for Ag+(no hydrolysis), FL “turn-on” and CD “turn-off” for Hg^(+)(imine hydrolysis), and FL “self-threshold ratiometric” and CD “turn-off” for excess Cu^(2+)(lactone and imine hydrolysis), providing the first example of a fluorescence/CD dual-modality probe for multiple species with complimentary responses. Moreover, the bond-cleavage cascade reactions also lead to the formation of D-penicillamine heavy metal ion complexes for potential detoxification treatments.展开更多
A biodegradable tumor targeting nano-probe based on poly（ε-caprolactone）-b-poly（ethylene glycol） block copolymer （PCL-b-PEG）micelle functionalized with a magnetic resonance imaging （MRI） contrast agent diethy...A biodegradable tumor targeting nano-probe based on poly（ε-caprolactone）-b-poly（ethylene glycol） block copolymer （PCL-b-PEG）micelle functionalized with a magnetic resonance imaging （MRI） contrast agent diethylenetriaminepentaacetic acid-gadolinium （DTPA-Gd＋） on the shell and a near-infrared （NIR） dye in the core for magnetic resonance and optical dual-modality imaging was prepared. The longitudinal relaxivity （rl） of the PCL-b-PEG- DTPA-Gd3＋ micelle was 13.4 （mmol/L）^-1s^-1, three folds of that of DTPA-Gd3＋, and higher than that of many polymeric contrast agents with similar structures. The in vivo optical imaging of a nude mouse bearing xenografied breast tumor showed that the dual-modality micelle preferentially accumulated in the tumor via the folic acid-mediated active targeting and the passive accumulation by the enhanced permeability and retention （EPR） effect. The results indicated that the dualmodality micelle is a promising nano-probe for cancer detection and diagnosis.展开更多
We report on tests of combined positron emission tomography(PET)andfluorescence molecular tomography(FMT)imaging system for in vivo investigation on small animals.A nude mouse was inoculated with MD-MB-231 breast canc...We report on tests of combined positron emission tomography(PET)andfluorescence molecular tomography(FMT)imaging system for in vivo investigation on small animals.A nude mouse was inoculated with MD-MB-231 breast cancer cells which expressed redfluorescent protein(RFP).For FMT system,reflective illumination mode was adopted with full-angle data acquisition.[18F]-Fluorodeoxyglucose([18F]-FDG)was used as radioactive tracer for PET.Both data were acquired simultaneously and then reconstructed separately before fusion.Fluorescent tomography results showed exactly where the tumor was located while PET results offered more metabolic information.Results confirmed feasibility for tumor detection and showed superiority to single modality imaging.展开更多
The study designed a polyacrylic acid(PAA)modified Fe3O4@MnO2 nanoparticles(Fe3O4@MnO2@PAA)for T1/T2 dualmode imaging.In addition,this nano-drug has pH response and anti-tumor photothermal therapy.First,using Fe3O4 as...The study designed a polyacrylic acid(PAA)modified Fe3O4@MnO2 nanoparticles(Fe3O4@MnO2@PAA)for T1/T2 dualmode imaging.In addition,this nano-drug has pH response and anti-tumor photothermal therapy.First,using Fe3O4 as the core can significantly reduce the signal of Fe3O4@MnO2@PAA nanoparticles.MnO2 nanoshells can be decomposed into paramagnetic Mn2+under the acidic environment in the tumor,which enhanced the T1 signal.The pH-responsive T1/T2 dual-mode magnetic resonance imaging(MRI)contrast agent had good sensitivity and specificity,providing more comprehensive and detailed information for tumor diagnosis.In addition,Fe3O4@MnO2@PAA nanoparticles showed excellent absorption capacity in the near-infrared region(NIR),which could be used as a good photothermal conversion material to mediate photothermal treatment of tumors.Therefore,the pHresponsive dual-mode MRI nanoparticle-mediated photothermal therapy showed good application potential in tumor treatment and diagnosis.展开更多
Visual Question and Answering(VQA)has garnered significant attention as a domain that requires the synthesis of visual and textual information to produce accurate responses.While existing methods often rely on Convolu...Visual Question and Answering(VQA)has garnered significant attention as a domain that requires the synthesis of visual and textual information to produce accurate responses.While existing methods often rely on Convolutional Neural Networks(CNNs)for feature extraction and attention mechanisms for embedding learning,they frequently fail to capture the nuanced interactions between entities within images,leading to potential ambiguities in answer generation.In this paper,we introduce a novel network architecture,Dual-modality Integration Attention with Graph-based Feature Extraction(DIAGFE),which addresses these limitations by incorporating two key innovations:a Graph-based Feature Extraction(GFE)module that enhances the precision of visual semantics extraction,and a Dual-modality Integration Attention(DIA)mechanism that efficiently fuses visual and question features to guide the model towards more accurate answer generation.Our model is trained with a composite loss function to refine its predictive accuracy.Rigorous experiments on the VQA2.0 dataset demonstrate that DIAGFE outperforms existing methods,underscoring the effectiveness of our approach in advancing VQA research and its potential for cross-modal understanding.展开更多
Micro RNA-133a(mi RNA-133a) and cardiac troponin I(c Tn I) are different-type crucial biomarkers of acute myocardial infarction(AMI), whose levels are great significance for AMI diagnosis and treatment. Herein,a novel...Micro RNA-133a(mi RNA-133a) and cardiac troponin I(c Tn I) are different-type crucial biomarkers of acute myocardial infarction(AMI), whose levels are great significance for AMI diagnosis and treatment. Herein,a novel photoelectrochemical-electrochemical(PEC-EC) dual-mode biosensing platform for dual-target assays of mi RNA-133a and c Tn I was developed. In which, a PEC-EC dual-mode sensing platform for mi RNA-133a was constructed based on the changes of the photocurrent inhibition effect and the electrochemical signal of Fc on the Fc-hairpin DNA probe(Fc-HP)/Zn Cd S-quantum dots(QDs)/ITO electrode. Furthermore, under magnetic separation and the specific interaction between c Tn I and its aptamer, the N-doped porous carbon-Zn O polyhedra(NPC-Zn O)-hemin-capture DNA probe hybrid(NH-CP) was obtained and introduced to the Fc-HP/Zn Cd S-QDs/ITO electrode via hybridization between NH-CP and Fc-HP. The hemin molecules encapsulated in NH-CP could effectively induce the photocurrent-polarity-switching of the FcHP/Zn Cd S-QDs/ITO electrode and generate a new electrochemical signal originating from hemin. Thus,c Tn I was assayed sensitively and selectively by the PEC-EC dual-mode biosensing platform. Here, Fc and hemin not only serve as the electrochemical indicators, but also respectively inhibit the photocurrent and switch the photocurrent polarity of Zn Cd S-QDs. Furthermore, the proposed biosensing platform could be easily expanded to the detection of other multiplex-type biomarkers via the change of the sequences of the related DNA probes, implying its significant potential in clinical diagnosis and biological analysis.展开更多
Photothermoelectric(PTE)photodetectors with selfpowered and uncooled advantages have attracted much interest due to the wide application prospects in the military and civilian fields.However,traditional PTE photodetec...Photothermoelectric(PTE)photodetectors with selfpowered and uncooled advantages have attracted much interest due to the wide application prospects in the military and civilian fields.However,traditional PTE photodetectors lack of mechanical flexibility and cannot operate independently without the test instrument.Herein,we present a flexible PTE photodetector capable of dual-mode output,combining electrical and optical signal generation for enhanced functionality.Using solution processing,high-quality MXene thin films are assembled on asymmetric electrodes as the photosensitive layer.The geometrically asymmetric electrode design significantly enhances the responsivity,achieving 0.33 m A W^(-1)under infrared illumination,twice that of the symmetrical configuration.This improvement stems from optimized photothermal conversion and an expanded temperature gradient.The PTE device maintains stable performance after 300 bending cycles,demonstrating excellent flexibility.A new energy conversion pathway has been established by coupling the photothermal conversion of MXene with thermochromic composite materials,leading to a real-time visualization of invisible infrared radiation.Leveraging this functionality,we demonstrate the first human-machine collaborative infrared imaging system,wherein the dual-mode photodetector arrays synchronously generate human-readable pattern and machine-readable pattern.Our study not only provides a new solution for functional integration of flexible photodetectors,but also sets a new benchmark for human-machine collaborative optoelectronics.展开更多
Transcatheter arterial embolization(TAE)is the mainstay for treating advanced hepatocellular carcinoma(HCC),and the performance of the embolization material is crucial in TAE.With the development of medical imaging an...Transcatheter arterial embolization(TAE)is the mainstay for treating advanced hepatocellular carcinoma(HCC),and the performance of the embolization material is crucial in TAE.With the development of medical imaging and the birth of“X-ray-free”technologies,we designed a new dual-mode imaging material of dimethoxy tetraphenyl ethylene(DMTPE)via emulsification by mixing poly(N-isopropylacrylamide-co-acrylic acid)(PNA)with lipiodol and fluorocarbons,which was evaluated for temperature sensitivity,stability,and dual-mode visualization in vitro.Additionally,blood vessel casting embolization and renal artery imaging were assessed in healthy rabbits.In a rabbit model with a VX2 tumor,the effectiveness of TAE for treating HCC was examined,with an emphasis on evaluating long-term outcomes of embolization and its effects on tumor growth,necrosis,and proliferation through imaging techniques.In vitro experiments confirmed that the temperature-sensitive dual-oil-phase Pickering emulsion had good flow,stable contrast,and embolism when the oil-to-oil ratio and water-to-oil ratio were both 7:3(v/v)and stabilized with 8%PNA.Similarly,in vivo,arterial embolization confirmed the excellent properties of DMTPE prepared at the abovementioned ratios.It was observed that DMTPE not only has an antitumor effect but can also achieve dual imaging using X-rays and ultrasound,making it a promising excellent vascular embolization material for TAE in tumor treatment.展开更多
This paper describes an experimental study investigating the effects of sinusoidal pulsed injection on the combustion mode transition in a dual-mode supersonic combustor.The results are obtained under inflow condition...This paper describes an experimental study investigating the effects of sinusoidal pulsed injection on the combustion mode transition in a dual-mode supersonic combustor.The results are obtained under inflow conditions of 2.9 MPa stagnation pressure,1900 K stagnation temperature,and Mach number of 3.0.It has been observed that,at the same equivalence ratio,the combustion mode and flow field structure undergo irreversible changes from a weak combustion state to a strong combustion state at a specific pulsed jet frequency compared to steady jet.For steady jet,the combustion mode is dual-mode.As the frequency of the unsteady jet changes,the combustion mode also changes:it becomes a transition mode at frequencies of 171 Hz and 260 Hz,and a ramjet mode at 216 Hz.Combustion instability under steady jet manifests as a transition in flame stabilization mode.In contrast,under pulsed jet,combustion instability appears either as a transition in flame stabilization mode or as flame blow-off and flashback.The flow field oscillation frequency in the non-reacting flow is 171 Hz,which may resonate with the 171 Hz pulsed jet frequency,making the combustion oscillations most pronounced at this frequency.When the jet frequency is increased to 216 Hz,the combustion intensity significantly increases,and the combustion mode transfers to the ramjet mode.However,further increasing the frequency to 260 Hz results in a decrease in combustion intensity,returning to the transition mode.The frequency of the flow field oscillations varies with the coupling of the pulsed injection frequency,shock wave,and flame,and if the system reaches an unstable state,that is,pre-combustion shock train moves far upstream of the isolator during the pulsed jet period,strong combustion state can be achieved,and this process is irreversible.展开更多
Tumor-targeted immunotherapy is a remarkable breakthrough,offering the inimitable advantage of specific tumoricidal effects with reduced immune-associated cytotoxicity.However,existing platforms suffer from low effica...Tumor-targeted immunotherapy is a remarkable breakthrough,offering the inimitable advantage of specific tumoricidal effects with reduced immune-associated cytotoxicity.However,existing platforms suffer from low efficacy,inability to induce strong immunogenic cell death(ICD),and restrained capacity of transforming immune-deserted tumors into immune-cultivated ones.Here,an innovative platform,perfluorooctyl bromide(PFOB)nanoemulsions holding MnO_(2) nanoparticles(MBP),was developed to orchestrate cancer immunotherapy,serving as a theranostic nanoagent for MRI/CT dual-modality imaging and advanced ICD.By simultaneously depleting the GSH and eliciting the ICD effect via highintensity focused ultrasound(HIFU)therapy,the MBP nanomedicine can regulate the tumor immune microenvironment by inducing maturation of dendritic cells(DCs)and facilitating the activation of CD8^(+)and CD4^(+)T cells.The synergistic GSH depletion and HIFU ablation also amplify the inhibition of tumor growth and lung metastasis.Together,these findings inaugurate a new strategy of tumor-targeted immunotherapy,realizing a novel therapeutics paradigm with great clinical significance.展开更多
Because of the intrinsic defects of traditional treatment of cancer,it is quite needed to construct novel theranostic nanoagents that can not only improve the accuracy of imaging diagnosis but also achieve highly effi...Because of the intrinsic defects of traditional treatment of cancer,it is quite needed to construct novel theranostic nanoagents that can not only improve the accuracy of imaging diagnosis but also achieve highly efficient therapy of cancer.Herein,we fabricated polydopamine-functionalized ammonium holmium fluoride nanocomposites(AHF@PDA)for dual-modality bioimaging(magnetic resonance imaging(MRI)and computed tomography(CT))owing to the high X-ray attenuation feature and magnetic property of Ho^(3+).Moreover,PDA shell endows AHF@PDA with excellent photothermal conversion performances and robust biocompatibility,leading to good treatment effect in vitro and in vivo.All above positive results certify that AHF@PDA have good potential as theranostic agents for clinical application in the future.展开更多
Norovirus(NoV)is regarded as one of the most common causes of foodborne diarrhea in the world.It is urgent to identify the pathogenic microorganism of the diarrhea in short time.In this work,we developed an electroche...Norovirus(NoV)is regarded as one of the most common causes of foodborne diarrhea in the world.It is urgent to identify the pathogenic microorganism of the diarrhea in short time.In this work,we developed an electrochemical and colorimetric dual-mode detection for NoV based on the excellent dual catalytic properties of copper peroxide/COF-NH_(2)nanocomposite(CuO_(2)@COF-NH_(2)).For the colorimetric detection,NoV can be directly detected by the naked eye based on CuO_(2)@COF-NH_(2)as a laccase-like nonazyme using“peptide-NoV-antibody”recognition mode.The colorimetric assay displayed a wide and quality linear detection range from 1 copy/mL to 5000 copies/mL of NoV with a low limit of detection(LOD)of 0.125 copy/mL.For the electrochemical detection of NoV,CuO_(2)@COF-NH_(2)showed an oxidation peak of copper ion from Cu^(+)to Cu^(2+)using“peptide-NoV-antibody”recognition mode.The electrochemical assay showed a linear detection range was 1-5000 copies/mL with a LOD of 0.152 copy/mL.It's worthy to note that this assay does not need other electrical signal molecule,which provide the stable and sensitive electrochemial detection for NoV.The electrochemical and colorimetric dual-mode detection was used to detect NoV in foods and faceal samples,which has the potential for improving food safety and diagnosing of NoV-infected diarrhea.展开更多
Dual-excitation and dual-emission Y_(4)GeO_(8):Bi^(3+),Sm^(3+)phosphors were manufactured by traditional solidphase sintering technique.The X-ray diffraction,morphology,photoluminescence,energy transfer process and te...Dual-excitation and dual-emission Y_(4)GeO_(8):Bi^(3+),Sm^(3+)phosphors were manufactured by traditional solidphase sintering technique.The X-ray diffraction,morphology,photoluminescence,energy transfer process and temperature sensing properties of Y_(4)GeO_(8):Bi^(3+),Sm^(3+)samples were comprehensively evaluated.The Y4GeO_(8):Bi^(3+),Sm^(3+)phosphors exhibit characteristic emissions of Bi^(3+)(^(3)P_(1)→^(1)S_(0)) and Sm^(3+)(^(4)G_(5/2)→^(6)H)under both 290 and 347 nm excitations.In fluorescence intensity ratio and Commission International de L'Eclairage coordinates modes,Y_(4)GeO_(8):Bi^(3+),Sm^(3+)samples present excellent temperature measurement performance.The maximum relative sensitivity(S_(r-max)) values of the former are 1.55%/K(460 K,290 nm excitation) and 0.82%/K(506 K,347 nm excitation).The S_(r-max)(x) values of the latter are 0.21 %/K(437 K,290 nm excitation) and 0.15%/K(513 K,347 nm excitation).These results illustrate that Y_(4)GeO_(8):Bi^(3+),Sm^(3+)phospho rs can be used as a candidate material for a dual-mode optical thermometer under dual-excitation.展开更多
Sweat loss monitoring is important for understanding the body’s thermoregulation and hydration status,as well as for comprehensive sweat analysis.Despite recent advances,developing a low-cost,scalable,and universal m...Sweat loss monitoring is important for understanding the body’s thermoregulation and hydration status,as well as for comprehensive sweat analysis.Despite recent advances,developing a low-cost,scalable,and universal method for the fabrication of colorimetric microfluidics designed for sweat loss monitoring remains challenging.In this study,we propose a novel laserengraved surface roughening strategy for various flexible substrates.This process permits the construction of microchannels that show distinct structural reflectance changes before and after sweat filling.By leveraging these unique optical properties,we have developed a fully laser-engraved microfluidic device for the quantification of naked-eye sweat loss.This sweat loss sensor is capable of a volume resolution of 0.5µL and a total volume capacity of 11µL,and can be customized to meet different performance requirements.Moreover,we report the development of a crosstalk-free dual-mode sweat microfluidic system that integrates an Ag/AgCl chloride sensor and a matching wireless measurement flexible printed circuit board.This integrated system enables the real-time monitoring of colorimetric sweat loss signals and potential ion concentration signals without crosstalk.Finally,we demonstrate the potential practical use of this microfluidic sweat loss sensor and its integrated system for sports medicine via on-body studies.展开更多
Taking apart in numerous physiological and pathological activities,hydrogen sulfide(H_(2)S)has been selected as an excellent target spot for the early diagnosis of cancer.So far,there are many mature probes that apply...Taking apart in numerous physiological and pathological activities,hydrogen sulfide(H_(2)S)has been selected as an excellent target spot for the early diagnosis of cancer.So far,there are many mature probes that apply single optical imaging to monitor endogenous H_(2)S.Nevertheless,a single modality is not an ideal method to afford accurate diagnostic information in comprehensive biological organisms.Herein,we developed a dual-modal imaging probe BWS.This designed probe showed a specific response to H_(2)S with both chemiluminescence and NIR fluorescence light-up.The concurrence of fluorescence and chemiluminescence signal provided“double insurances”for highly accurate monitoring of H_(2)S.Satisfactorily,this dual-modal imaging probe performed precise visualization of endogenous H_(2)S in living cells and in vivo.We envisaged that this chemiluminescence/fluorescence real-time dual-modality strategy for H_(2)S detection will expand and optimize the multimodal imaging methods for efficient diagnosis and treatment of cancer.展开更多
Highly sensitive and stable acetylcholinesterase detection is critical for diagnosing and treating various neurotransmission-related diseases.In this study,a novel colorimetric-fluorescent dual-mode biosensor based on...Highly sensitive and stable acetylcholinesterase detection is critical for diagnosing and treating various neurotransmission-related diseases.In this study,a novel colorimetric-fluorescent dual-mode biosensor based on highly dispersive trimetal-modified graphite-phase carbon nitride nanocomposites for acetylcholinesterase detection was designed and synthesized by phosphorus doping and a mixed-metal MOF strategy.The specific surface area of trimetal-modified graphite-phase carbon nitride nanocomposites increased from 15.81 to 96.69 g m^(-2),and its thermal stability,interfacial charge transfer,and oxidation-reduction capability were enhanced compared with those of graphite-phase carbon nitride.First-principles density functional theory calculations and steady-state kinetic analysis are applied to investigate the electronic structures and efficient peroxidase-mimicking properties of trimetal-modified graphite-phase carbon nitride nanocomposites.The oxidation of 3,3',5,5'-tetramethylbenzidin was inhibited by thiocholine,which originates from the decomposition of thiocholine iodide by Acetyl-cholinesterase(AChE),resulting in changes in fluorescence and absorbance intensity.Due to the independence and complementarity of the signals,a highly precise colorimetric-fluorescent dual-mode biosensor with a linear range for detecting AChE of 4-20μU mL^(-1) and detection limits of 0.13μU mL^(-1)(colorimetric)and 0.04μU mL^(-1)(fluorescence)was developed.The spiking recovery of AChE in actual samples was 99.0%-100.4%.Therefore,a highly accurate,specific,and stable dual-mode biosensor is available for AChE detection,and this biosensor has the potential for the analysis of other biomarkers.展开更多
Nowadays, the global climate is constantly being destroyed and the fluctuations in ambient temperature are becoming more frequent. However, conventional single-mode thermal management strategies(heating or cooling) fa...Nowadays, the global climate is constantly being destroyed and the fluctuations in ambient temperature are becoming more frequent. However, conventional single-mode thermal management strategies(heating or cooling) failed to resolve such dynamic temperature changes. Moreover, developing thermal management devices capable of accommodating these temperature variations while remaining simple to fabricate and durable has remained a formidable obstacle. To address these bottlenecks, we design and successfully fabricate a novel dual-mode hierarchical(DMH) composite film featuring a micronanofiber network structure, achieved through a straightforward two-step continuous electrospinning process. In cooling mode, it presents a high solar reflectivity of up to 97.7% and an excellent atmospheric transparent window(ATW) infrared emissivity of up to 98.9%. Noted that this DMH film could realize a cooling of 8.1 ℃ compared to the ambient temperature outdoors. In heating mode, it also exhibits a high solar absorptivity of 94.7% and heats up to 11.9 ℃ higher than black cotton fabric when utilized by individuals. In practical application scenarios, a seamless transition between efficient cooling and heating is achieved by simply flipping the film. More importantly, the DMH film combining the benefits of composites demonstrates portability, durability, and easy-cleaning, promising to achieve large-scale production and use of thermally managed textiles in the future. The energy savings offered by film applications provide a viable solution for the early realization of carbon neutrality.展开更多
Magnetic resonance imaging(MRI)is a non-invasive medical imaging technique that has been widely applied in the clinical diagnosis of diseases across various fields.Currently,there is a dearth of high-performance dual-...Magnetic resonance imaging(MRI)is a non-invasive medical imaging technique that has been widely applied in the clinical diagnosis of diseases across various fields.Currently,there is a dearth of high-performance dual-mode contrast agents that provide precise diagnostic information for complex diseases.In this study,iron oxide-gadolinium nanoparticles(IO-Gd NPs)bridged by hydrophilic ligand ethylenedi-amine tetramethylenephosphonic acid(EDTMP)are designed inspired by Solomon-Bloembergen-Morgan(SBM)theory,where T_(1)and T_(2)relaxivity increase with a reduction in Gd content.In particular,the NPs with minimum Gd content exhibit excellent dual-mode contrast performance(r_(1)=94.42 mM^(−1)s^(−1),r_(2)=343.62 mM^(−1)s^(−1)).The underlying mechanism is that the bridged EDTMP coordinate limits Gd tum-bling and forces Gd^(3+)to expose itself to the surface of the NPs.This provides more opportunities for water molecules to coordinate with Gd^(3+)and significantly enhances proton relaxivity.Moreover,the hy-drophilicity of the ligand enhances the water dispersion stability of the NPs and increases the exchange rate of water protons near the NPs,further enhancing the dual-mode contrast effect.Finally,the biocom-patibility and in vitro/vivo imaging performances of the IO@EDTMP-Gd NPs are systematically evaluated,and the results demonstrate their potential as dual-mode contrast agents.This study provides a new strategy for developing dual-mode MRI contrast agents that can further improve the accuracy of MRI in the diagnosis of complex diseases.展开更多
The microstrip dual-mode filter （DMF） with conventional coupling structure has some limitations in- eluding the port coupling strength limited by fabrication tolerance and the existence of serious second order spuri...The microstrip dual-mode filter （DMF） with conventional coupling structure has some limitations in- eluding the port coupling strength limited by fabrication tolerance and the existence of serious second order spuri- ous band. Therefore, a novel DMF with a offset-feed bended coupling structure and a stepped-impedance dual- mode resonator is proposed for coupling enhancement and spurious response suppression. Based on the analysis of the change of spur frequencies and the current distribution of spur resonant modes, all spurs near passband of the cascaded DMF can be fully suppressed by optimizing the structure parameters of parasite resonators, which bene- fits from the inherent well-controlled transmission zeros. Experimental results show that the proposed DMF ex- hibits lower insertion loss ,much sharper rate of cutoff and wider spur-free stop band compared with conventional DMF. This design is applicable for spur suppression in wideband communication.展开更多
基金Supported by 2021 Municipal Health Commission Scientific Research Project,No.WX21D482021 Municipal Health Commission Project,No.WZ21Q112022 Hubei Provincial Department of Science and Technology Project,No.2022CFB980.
文摘BACKGROUND Bile duct stones(BDSs)may cause patients to develop liver cirrhosis or even liver cancer.Currently,the success rate of surgical treatment for intrahepatic and extrahepatic BDSs is not satisfactory,and there is a risk of postoperative complic-ations.AIM To compare the clinical effects of dual-modality endoscopy(duodenoscopy and laparoscopy)with those of traditional laparotomy in the treatment of intra-and extrahepatic BDSs.METHODS Ninety-five patients with intra-and extrahepatic BDSs who sought medical services at Wuhan No.1 Hospital between August 2019 and May 2023 were selected;45 patients in the control group were treated by traditional laparotomy,and 50 patients in the research group were treated by dual-modality endoscopy.The following factors were collected for analysis:curative effects,safety(incision infection,biliary fistula,lung infection,hemobilia),surgical factors[surgery time,intraoperative blood loss(IBL)volume,gastrointestinal function recovery time,and length of hospital stay],serum inflammatory markers[tumor necrosis factor(TNF)-α,interleukin(IL)-6,and IL-8],and oxidative stress[glutathione peroxidase(GSH-Px),superoxide dismutase(SOD),malondialdehyde(MDA),and advanced protein oxidation products(AOPPs)].RESULTS The analysis revealed markedly better efficacy(an obviously higher total effective rate)in the research group than in the control group.In addition,an evidently lower postoperative complication rate,shorter surgical duration,gastrointestinal function recovery time and hospital stay,and lower IBL volume were observed in the research group.Furthermore,the posttreatment serum inflammatory marker(TNF-α,IL-6,and IL-8)levels were significantly lower in the research group than in the control group.Compared with those in the control group,the posttreatment GSH-Px,SOD,MDA and AOPPs in the research group were equivalent to the pretreatment levels;for example,the GSH-Px and SOD levels were significantly higher,while the MDA and AOPP levels were lower.CONCLUSION Dual-modality endoscopy therapy(duodenoscopy and laparoscopy)is more effective than traditional laparotomy in the treatment of intra-and extrahepatic BDSs and has a lower risk of postoperative complications;significantly shortened surgical time;shorter gastrointestinal function recovery time;shorter hospital stay;and lower intraop-erative bleeding volume,while having a significant inhibitory effect on excessive serum inflammation and causing little postoperative oxidative stress.
基金supported by the National Natural Science Foundation of China (Nos. 21577037 and 21738002)the State Key Laboratory of Bioreactor Engineering, Shanghai Natural Science Fund (No. 20ZR1414700)+2 种基金Shanghai Sailing Program (No. 19YF1412500)Natural Science Basic Research Program of Shaanxi (No. 2019JQ-924)Key Breeding Program by Collaborative Innovation Center of Green Manufacturing Technology for Traditional Chinese Medicine in Shaanxi Province (No. 2019XT-1-03)。
文摘Selective detection of multiple analytes in a compact design with dual-modality and theranostic features presents great challenges. Herein, we wish to report a coumarin-thiazolidine masked D-penicillamine based dual-modality fluorescent probe COU-DPA-1 for selective detection, differentiation, and detoxification of multiple heavy metal ions(Ag^(+), Hg^(2+), Cu^(2+)). The probe shows divergent fluorescence(FL)/circular dichroism(CD) responses via divergent bond-cleavage cascade reactions(metal ion promoted C-S cleavage and hydrolysis at two distinctive cleavage sites): FL “turn-off” and CD “turn-on” for Ag+(no hydrolysis), FL “turn-on” and CD “turn-off” for Hg^(+)(imine hydrolysis), and FL “self-threshold ratiometric” and CD “turn-off” for excess Cu^(2+)(lactone and imine hydrolysis), providing the first example of a fluorescence/CD dual-modality probe for multiple species with complimentary responses. Moreover, the bond-cleavage cascade reactions also lead to the formation of D-penicillamine heavy metal ion complexes for potential detoxification treatments.
基金supported by the National Natural Science Foundation of China(No.20904046)the National Basic Research Program(973 Program)(No.2009CB526403) of China+1 种基金the Doctoral Fund of Ministry of Education of China(No.20090101120159)the Qianjiang Talent Program of Zhejiang Province,China(No.2010R10050)
文摘A biodegradable tumor targeting nano-probe based on poly（ε-caprolactone）-b-poly（ethylene glycol） block copolymer （PCL-b-PEG）micelle functionalized with a magnetic resonance imaging （MRI） contrast agent diethylenetriaminepentaacetic acid-gadolinium （DTPA-Gd＋） on the shell and a near-infrared （NIR） dye in the core for magnetic resonance and optical dual-modality imaging was prepared. The longitudinal relaxivity （rl） of the PCL-b-PEG- DTPA-Gd3＋ micelle was 13.4 （mmol/L）^-1s^-1, three folds of that of DTPA-Gd3＋, and higher than that of many polymeric contrast agents with similar structures. The in vivo optical imaging of a nude mouse bearing xenografied breast tumor showed that the dual-modality micelle preferentially accumulated in the tumor via the folic acid-mediated active targeting and the passive accumulation by the enhanced permeability and retention （EPR） effect. The results indicated that the dualmodality micelle is a promising nano-probe for cancer detection and diagnosis.
基金The authors would like to thank X.Zhang,faculty of XinAoMDT Technology Co.,Ltd.,for the work of system software development.This work is supported by the National Natural Science Foundation of China under Grant Nos.81071191,60831003,30930092,30872633the Tsinghua-Yue-Yuen Medical Science Foundationthe National Basic Research Program of China(973)under Grant No.2011CB707701.
文摘We report on tests of combined positron emission tomography(PET)andfluorescence molecular tomography(FMT)imaging system for in vivo investigation on small animals.A nude mouse was inoculated with MD-MB-231 breast cancer cells which expressed redfluorescent protein(RFP).For FMT system,reflective illumination mode was adopted with full-angle data acquisition.[18F]-Fluorodeoxyglucose([18F]-FDG)was used as radioactive tracer for PET.Both data were acquired simultaneously and then reconstructed separately before fusion.Fluorescent tomography results showed exactly where the tumor was located while PET results offered more metabolic information.Results confirmed feasibility for tumor detection and showed superiority to single modality imaging.
文摘The study designed a polyacrylic acid(PAA)modified Fe3O4@MnO2 nanoparticles(Fe3O4@MnO2@PAA)for T1/T2 dualmode imaging.In addition,this nano-drug has pH response and anti-tumor photothermal therapy.First,using Fe3O4 as the core can significantly reduce the signal of Fe3O4@MnO2@PAA nanoparticles.MnO2 nanoshells can be decomposed into paramagnetic Mn2+under the acidic environment in the tumor,which enhanced the T1 signal.The pH-responsive T1/T2 dual-mode magnetic resonance imaging(MRI)contrast agent had good sensitivity and specificity,providing more comprehensive and detailed information for tumor diagnosis.In addition,Fe3O4@MnO2@PAA nanoparticles showed excellent absorption capacity in the near-infrared region(NIR),which could be used as a good photothermal conversion material to mediate photothermal treatment of tumors.Therefore,the pHresponsive dual-mode MRI nanoparticle-mediated photothermal therapy showed good application potential in tumor treatment and diagnosis.
基金supported by the Major Scientific and Technological Projects of China National Petroleum Corporation(CNPC)(No.ZD2019-183-001)the Fundamental Research Funds for the Central Universities(Nos.22CX01001A-1 and 22CX01001A-3).
文摘Visual Question and Answering(VQA)has garnered significant attention as a domain that requires the synthesis of visual and textual information to produce accurate responses.While existing methods often rely on Convolutional Neural Networks(CNNs)for feature extraction and attention mechanisms for embedding learning,they frequently fail to capture the nuanced interactions between entities within images,leading to potential ambiguities in answer generation.In this paper,we introduce a novel network architecture,Dual-modality Integration Attention with Graph-based Feature Extraction(DIAGFE),which addresses these limitations by incorporating two key innovations:a Graph-based Feature Extraction(GFE)module that enhances the precision of visual semantics extraction,and a Dual-modality Integration Attention(DIA)mechanism that efficiently fuses visual and question features to guide the model towards more accurate answer generation.Our model is trained with a composite loss function to refine its predictive accuracy.Rigorous experiments on the VQA2.0 dataset demonstrate that DIAGFE outperforms existing methods,underscoring the effectiveness of our approach in advancing VQA research and its potential for cross-modal understanding.
基金financially supported by National Natural Science Foundation of China (Nos. 22074033, 22374035)。
文摘Micro RNA-133a(mi RNA-133a) and cardiac troponin I(c Tn I) are different-type crucial biomarkers of acute myocardial infarction(AMI), whose levels are great significance for AMI diagnosis and treatment. Herein,a novel photoelectrochemical-electrochemical(PEC-EC) dual-mode biosensing platform for dual-target assays of mi RNA-133a and c Tn I was developed. In which, a PEC-EC dual-mode sensing platform for mi RNA-133a was constructed based on the changes of the photocurrent inhibition effect and the electrochemical signal of Fc on the Fc-hairpin DNA probe(Fc-HP)/Zn Cd S-quantum dots(QDs)/ITO electrode. Furthermore, under magnetic separation and the specific interaction between c Tn I and its aptamer, the N-doped porous carbon-Zn O polyhedra(NPC-Zn O)-hemin-capture DNA probe hybrid(NH-CP) was obtained and introduced to the Fc-HP/Zn Cd S-QDs/ITO electrode via hybridization between NH-CP and Fc-HP. The hemin molecules encapsulated in NH-CP could effectively induce the photocurrent-polarity-switching of the FcHP/Zn Cd S-QDs/ITO electrode and generate a new electrochemical signal originating from hemin. Thus,c Tn I was assayed sensitively and selectively by the PEC-EC dual-mode biosensing platform. Here, Fc and hemin not only serve as the electrochemical indicators, but also respectively inhibit the photocurrent and switch the photocurrent polarity of Zn Cd S-QDs. Furthermore, the proposed biosensing platform could be easily expanded to the detection of other multiplex-type biomarkers via the change of the sequences of the related DNA probes, implying its significant potential in clinical diagnosis and biological analysis.
基金supported by the Fundamental Research Funds for the Central Universities(xxj022019009)。
文摘Photothermoelectric(PTE)photodetectors with selfpowered and uncooled advantages have attracted much interest due to the wide application prospects in the military and civilian fields.However,traditional PTE photodetectors lack of mechanical flexibility and cannot operate independently without the test instrument.Herein,we present a flexible PTE photodetector capable of dual-mode output,combining electrical and optical signal generation for enhanced functionality.Using solution processing,high-quality MXene thin films are assembled on asymmetric electrodes as the photosensitive layer.The geometrically asymmetric electrode design significantly enhances the responsivity,achieving 0.33 m A W^(-1)under infrared illumination,twice that of the symmetrical configuration.This improvement stems from optimized photothermal conversion and an expanded temperature gradient.The PTE device maintains stable performance after 300 bending cycles,demonstrating excellent flexibility.A new energy conversion pathway has been established by coupling the photothermal conversion of MXene with thermochromic composite materials,leading to a real-time visualization of invisible infrared radiation.Leveraging this functionality,we demonstrate the first human-machine collaborative infrared imaging system,wherein the dual-mode photodetector arrays synchronously generate human-readable pattern and machine-readable pattern.Our study not only provides a new solution for functional integration of flexible photodetectors,but also sets a new benchmark for human-machine collaborative optoelectronics.
基金supported by the Hubei Province Nature Science Foundation of China(Grant No.:2023AFB1077)the National Natural Science Foundation of China(Grant No.:82003308)+2 种基金the Doctoral Start-up Fund Project of Hubei University of Science and Technology,China(Grant No.:BK202118)the Innovation team and Medical research program of Hubei University of Science and Technology,China(Grant Nos.:2023T10 and 2022YKY05)the Hubei Province Key R&D Plan Big Health Local Special Project,China(Grant No.:2022BCE042).
文摘Transcatheter arterial embolization(TAE)is the mainstay for treating advanced hepatocellular carcinoma(HCC),and the performance of the embolization material is crucial in TAE.With the development of medical imaging and the birth of“X-ray-free”technologies,we designed a new dual-mode imaging material of dimethoxy tetraphenyl ethylene(DMTPE)via emulsification by mixing poly(N-isopropylacrylamide-co-acrylic acid)(PNA)with lipiodol and fluorocarbons,which was evaluated for temperature sensitivity,stability,and dual-mode visualization in vitro.Additionally,blood vessel casting embolization and renal artery imaging were assessed in healthy rabbits.In a rabbit model with a VX2 tumor,the effectiveness of TAE for treating HCC was examined,with an emphasis on evaluating long-term outcomes of embolization and its effects on tumor growth,necrosis,and proliferation through imaging techniques.In vitro experiments confirmed that the temperature-sensitive dual-oil-phase Pickering emulsion had good flow,stable contrast,and embolism when the oil-to-oil ratio and water-to-oil ratio were both 7:3(v/v)and stabilized with 8%PNA.Similarly,in vivo,arterial embolization confirmed the excellent properties of DMTPE prepared at the abovementioned ratios.It was observed that DMTPE not only has an antitumor effect but can also achieve dual imaging using X-rays and ultrasound,making it a promising excellent vascular embolization material for TAE in tumor treatment.
基金supported by the Program of Key Laboratory of Cross-Domain Flight Interdisciplinary Technology,China(No.2023-ZY0205)。
文摘This paper describes an experimental study investigating the effects of sinusoidal pulsed injection on the combustion mode transition in a dual-mode supersonic combustor.The results are obtained under inflow conditions of 2.9 MPa stagnation pressure,1900 K stagnation temperature,and Mach number of 3.0.It has been observed that,at the same equivalence ratio,the combustion mode and flow field structure undergo irreversible changes from a weak combustion state to a strong combustion state at a specific pulsed jet frequency compared to steady jet.For steady jet,the combustion mode is dual-mode.As the frequency of the unsteady jet changes,the combustion mode also changes:it becomes a transition mode at frequencies of 171 Hz and 260 Hz,and a ramjet mode at 216 Hz.Combustion instability under steady jet manifests as a transition in flame stabilization mode.In contrast,under pulsed jet,combustion instability appears either as a transition in flame stabilization mode or as flame blow-off and flashback.The flow field oscillation frequency in the non-reacting flow is 171 Hz,which may resonate with the 171 Hz pulsed jet frequency,making the combustion oscillations most pronounced at this frequency.When the jet frequency is increased to 216 Hz,the combustion intensity significantly increases,and the combustion mode transfers to the ramjet mode.However,further increasing the frequency to 260 Hz results in a decrease in combustion intensity,returning to the transition mode.The frequency of the flow field oscillations varies with the coupling of the pulsed injection frequency,shock wave,and flame,and if the system reaches an unstable state,that is,pre-combustion shock train moves far upstream of the isolator during the pulsed jet period,strong combustion state can be achieved,and this process is irreversible.
基金supported by Shanghai Municipal Science and Technology Major Project(No.2018SHZDZX01,China)ZJ Lab,Shanghai Natural Science Foundation(Grant No.18ZR1405700,China)+3 种基金National Natural Science Foundation of China(Fund Nos.81773283 and 81901697)Shanghai Sailing Program(Grant No.18YF1403000,China)Shanghai Chest Hospital Project of Collaborative Innovation(Grant No.YJXT20190203,China)the Opening Project of State Key Laboratory of High Performance Ceramics and Superfine Microstructure(SKL201908SIC,China)。
文摘Tumor-targeted immunotherapy is a remarkable breakthrough,offering the inimitable advantage of specific tumoricidal effects with reduced immune-associated cytotoxicity.However,existing platforms suffer from low efficacy,inability to induce strong immunogenic cell death(ICD),and restrained capacity of transforming immune-deserted tumors into immune-cultivated ones.Here,an innovative platform,perfluorooctyl bromide(PFOB)nanoemulsions holding MnO_(2) nanoparticles(MBP),was developed to orchestrate cancer immunotherapy,serving as a theranostic nanoagent for MRI/CT dual-modality imaging and advanced ICD.By simultaneously depleting the GSH and eliciting the ICD effect via highintensity focused ultrasound(HIFU)therapy,the MBP nanomedicine can regulate the tumor immune microenvironment by inducing maturation of dendritic cells(DCs)and facilitating the activation of CD8^(+)and CD4^(+)T cells.The synergistic GSH depletion and HIFU ablation also amplify the inhibition of tumor growth and lung metastasis.Together,these findings inaugurate a new strategy of tumor-targeted immunotherapy,realizing a novel therapeutics paradigm with great clinical significance.
基金supported by the National Natural Science Foundation of China(51502284,21834007,21521092,21590794,52022094,21673220)the Program of Science and Technology Development Plan of Jilin Province of China(20170101186JC)+1 种基金the Strategic Priority Research Program of the Chinese Academy of Sciences(XDB20030300)the Youth Innovation Promotion Association of Chinese Academy of Sciences(2019232)。
文摘Because of the intrinsic defects of traditional treatment of cancer,it is quite needed to construct novel theranostic nanoagents that can not only improve the accuracy of imaging diagnosis but also achieve highly efficient therapy of cancer.Herein,we fabricated polydopamine-functionalized ammonium holmium fluoride nanocomposites(AHF@PDA)for dual-modality bioimaging(magnetic resonance imaging(MRI)and computed tomography(CT))owing to the high X-ray attenuation feature and magnetic property of Ho^(3+).Moreover,PDA shell endows AHF@PDA with excellent photothermal conversion performances and robust biocompatibility,leading to good treatment effect in vitro and in vivo.All above positive results certify that AHF@PDA have good potential as theranostic agents for clinical application in the future.
基金financially supported by National Key Research and Development Program of China(2022YFC2601604)Major science and technology project of Yunnan Province(202202AE090085)+9 种基金the National Natural Science Foundation of China(3216059732160236)Science and technology talent and platform plan of YunnanKey Scientific and Technology Project of Yunnan(202203AC100010)Spring City Plan:the High-level Talent Promotion and Training Project of Kunming(2022SCP001)the second phase of“Double-First Class”program construction of Yunnan Universitygrants from State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan,Yunnan University(2021KF005)Key Scientific and Technology Project of Yunnan(202002AE320005)Program for Excellent Young Talents of Yunnan Universitythe Program for Donglu Scholars of Yunnan University。
文摘Norovirus(NoV)is regarded as one of the most common causes of foodborne diarrhea in the world.It is urgent to identify the pathogenic microorganism of the diarrhea in short time.In this work,we developed an electrochemical and colorimetric dual-mode detection for NoV based on the excellent dual catalytic properties of copper peroxide/COF-NH_(2)nanocomposite(CuO_(2)@COF-NH_(2)).For the colorimetric detection,NoV can be directly detected by the naked eye based on CuO_(2)@COF-NH_(2)as a laccase-like nonazyme using“peptide-NoV-antibody”recognition mode.The colorimetric assay displayed a wide and quality linear detection range from 1 copy/mL to 5000 copies/mL of NoV with a low limit of detection(LOD)of 0.125 copy/mL.For the electrochemical detection of NoV,CuO_(2)@COF-NH_(2)showed an oxidation peak of copper ion from Cu^(+)to Cu^(2+)using“peptide-NoV-antibody”recognition mode.The electrochemical assay showed a linear detection range was 1-5000 copies/mL with a LOD of 0.152 copy/mL.It's worthy to note that this assay does not need other electrical signal molecule,which provide the stable and sensitive electrochemial detection for NoV.The electrochemical and colorimetric dual-mode detection was used to detect NoV in foods and faceal samples,which has the potential for improving food safety and diagnosing of NoV-infected diarrhea.
基金supported by the National Natural Science Foundation of China (11974315)。
文摘Dual-excitation and dual-emission Y_(4)GeO_(8):Bi^(3+),Sm^(3+)phosphors were manufactured by traditional solidphase sintering technique.The X-ray diffraction,morphology,photoluminescence,energy transfer process and temperature sensing properties of Y_(4)GeO_(8):Bi^(3+),Sm^(3+)samples were comprehensively evaluated.The Y4GeO_(8):Bi^(3+),Sm^(3+)phosphors exhibit characteristic emissions of Bi^(3+)(^(3)P_(1)→^(1)S_(0)) and Sm^(3+)(^(4)G_(5/2)→^(6)H)under both 290 and 347 nm excitations.In fluorescence intensity ratio and Commission International de L'Eclairage coordinates modes,Y_(4)GeO_(8):Bi^(3+),Sm^(3+)samples present excellent temperature measurement performance.The maximum relative sensitivity(S_(r-max)) values of the former are 1.55%/K(460 K,290 nm excitation) and 0.82%/K(506 K,347 nm excitation).The S_(r-max)(x) values of the latter are 0.21 %/K(437 K,290 nm excitation) and 0.15%/K(513 K,347 nm excitation).These results illustrate that Y_(4)GeO_(8):Bi^(3+),Sm^(3+)phospho rs can be used as a candidate material for a dual-mode optical thermometer under dual-excitation.
基金support from the National Natural Science Foundation of China(No.62174152)。
文摘Sweat loss monitoring is important for understanding the body’s thermoregulation and hydration status,as well as for comprehensive sweat analysis.Despite recent advances,developing a low-cost,scalable,and universal method for the fabrication of colorimetric microfluidics designed for sweat loss monitoring remains challenging.In this study,we propose a novel laserengraved surface roughening strategy for various flexible substrates.This process permits the construction of microchannels that show distinct structural reflectance changes before and after sweat filling.By leveraging these unique optical properties,we have developed a fully laser-engraved microfluidic device for the quantification of naked-eye sweat loss.This sweat loss sensor is capable of a volume resolution of 0.5µL and a total volume capacity of 11µL,and can be customized to meet different performance requirements.Moreover,we report the development of a crosstalk-free dual-mode sweat microfluidic system that integrates an Ag/AgCl chloride sensor and a matching wireless measurement flexible printed circuit board.This integrated system enables the real-time monitoring of colorimetric sweat loss signals and potential ion concentration signals without crosstalk.Finally,we demonstrate the potential practical use of this microfluidic sweat loss sensor and its integrated system for sports medicine via on-body studies.
基金supported by the National Natural Science Foundation of China(22077030,22271092,21977018,82173657)the China Postdoctoral Science Foundation(2021M701196)。
文摘Taking apart in numerous physiological and pathological activities,hydrogen sulfide(H_(2)S)has been selected as an excellent target spot for the early diagnosis of cancer.So far,there are many mature probes that apply single optical imaging to monitor endogenous H_(2)S.Nevertheless,a single modality is not an ideal method to afford accurate diagnostic information in comprehensive biological organisms.Herein,we developed a dual-modal imaging probe BWS.This designed probe showed a specific response to H_(2)S with both chemiluminescence and NIR fluorescence light-up.The concurrence of fluorescence and chemiluminescence signal provided“double insurances”for highly accurate monitoring of H_(2)S.Satisfactorily,this dual-modal imaging probe performed precise visualization of endogenous H_(2)S in living cells and in vivo.We envisaged that this chemiluminescence/fluorescence real-time dual-modality strategy for H_(2)S detection will expand and optimize the multimodal imaging methods for efficient diagnosis and treatment of cancer.
基金supported by the Hubei University of Technology Graduate Research Innovation Project(No.2022048)the Natural Science Foundation Project of Hubei Province(grant No.2022CFB533)+1 种基金the Scientific Research Plan of Education Department of Hubei Province(grant No.D20222702)the Natural Science Project of Xiaogan city(grant No.XGKJ20210100014).
文摘Highly sensitive and stable acetylcholinesterase detection is critical for diagnosing and treating various neurotransmission-related diseases.In this study,a novel colorimetric-fluorescent dual-mode biosensor based on highly dispersive trimetal-modified graphite-phase carbon nitride nanocomposites for acetylcholinesterase detection was designed and synthesized by phosphorus doping and a mixed-metal MOF strategy.The specific surface area of trimetal-modified graphite-phase carbon nitride nanocomposites increased from 15.81 to 96.69 g m^(-2),and its thermal stability,interfacial charge transfer,and oxidation-reduction capability were enhanced compared with those of graphite-phase carbon nitride.First-principles density functional theory calculations and steady-state kinetic analysis are applied to investigate the electronic structures and efficient peroxidase-mimicking properties of trimetal-modified graphite-phase carbon nitride nanocomposites.The oxidation of 3,3',5,5'-tetramethylbenzidin was inhibited by thiocholine,which originates from the decomposition of thiocholine iodide by Acetyl-cholinesterase(AChE),resulting in changes in fluorescence and absorbance intensity.Due to the independence and complementarity of the signals,a highly precise colorimetric-fluorescent dual-mode biosensor with a linear range for detecting AChE of 4-20μU mL^(-1) and detection limits of 0.13μU mL^(-1)(colorimetric)and 0.04μU mL^(-1)(fluorescence)was developed.The spiking recovery of AChE in actual samples was 99.0%-100.4%.Therefore,a highly accurate,specific,and stable dual-mode biosensor is available for AChE detection,and this biosensor has the potential for the analysis of other biomarkers.
基金financially Fundamental Research Funds for the Central Universities (2232021G-04 and 2232020D-20)Student Innovation Fund of Donghua University (GSIF-DH-M-2021003)。
文摘Nowadays, the global climate is constantly being destroyed and the fluctuations in ambient temperature are becoming more frequent. However, conventional single-mode thermal management strategies(heating or cooling) failed to resolve such dynamic temperature changes. Moreover, developing thermal management devices capable of accommodating these temperature variations while remaining simple to fabricate and durable has remained a formidable obstacle. To address these bottlenecks, we design and successfully fabricate a novel dual-mode hierarchical(DMH) composite film featuring a micronanofiber network structure, achieved through a straightforward two-step continuous electrospinning process. In cooling mode, it presents a high solar reflectivity of up to 97.7% and an excellent atmospheric transparent window(ATW) infrared emissivity of up to 98.9%. Noted that this DMH film could realize a cooling of 8.1 ℃ compared to the ambient temperature outdoors. In heating mode, it also exhibits a high solar absorptivity of 94.7% and heats up to 11.9 ℃ higher than black cotton fabric when utilized by individuals. In practical application scenarios, a seamless transition between efficient cooling and heating is achieved by simply flipping the film. More importantly, the DMH film combining the benefits of composites demonstrates portability, durability, and easy-cleaning, promising to achieve large-scale production and use of thermally managed textiles in the future. The energy savings offered by film applications provide a viable solution for the early realization of carbon neutrality.
基金supported by the National Key R&D Program of China(Nos.2020YFA0710800,2022YFE0124500)the National Natural Science Foundation of China(Nos.32271467,32071364)+1 种基金the Outstanding Postdoctoral Program of Jiangsu Province(No.2022ZB367)the Priority Academic Program Development of Jiangsu Higher Education Institutions(PAPD).
文摘Magnetic resonance imaging(MRI)is a non-invasive medical imaging technique that has been widely applied in the clinical diagnosis of diseases across various fields.Currently,there is a dearth of high-performance dual-mode contrast agents that provide precise diagnostic information for complex diseases.In this study,iron oxide-gadolinium nanoparticles(IO-Gd NPs)bridged by hydrophilic ligand ethylenedi-amine tetramethylenephosphonic acid(EDTMP)are designed inspired by Solomon-Bloembergen-Morgan(SBM)theory,where T_(1)and T_(2)relaxivity increase with a reduction in Gd content.In particular,the NPs with minimum Gd content exhibit excellent dual-mode contrast performance(r_(1)=94.42 mM^(−1)s^(−1),r_(2)=343.62 mM^(−1)s^(−1)).The underlying mechanism is that the bridged EDTMP coordinate limits Gd tum-bling and forces Gd^(3+)to expose itself to the surface of the NPs.This provides more opportunities for water molecules to coordinate with Gd^(3+)and significantly enhances proton relaxivity.Moreover,the hy-drophilicity of the ligand enhances the water dispersion stability of the NPs and increases the exchange rate of water protons near the NPs,further enhancing the dual-mode contrast effect.Finally,the biocom-patibility and in vitro/vivo imaging performances of the IO@EDTMP-Gd NPs are systematically evaluated,and the results demonstrate their potential as dual-mode contrast agents.This study provides a new strategy for developing dual-mode MRI contrast agents that can further improve the accuracy of MRI in the diagnosis of complex diseases.
基金Supported by the National Natural Science Foundation of China under Grant(60921063)the National Program on Key Basic Research Project(973Program)(2010CB327400)the National Science and Technology Major Project(2010ZX03007-002-01)~~
文摘The microstrip dual-mode filter （DMF） with conventional coupling structure has some limitations in- eluding the port coupling strength limited by fabrication tolerance and the existence of serious second order spuri- ous band. Therefore, a novel DMF with a offset-feed bended coupling structure and a stepped-impedance dual- mode resonator is proposed for coupling enhancement and spurious response suppression. Based on the analysis of the change of spur frequencies and the current distribution of spur resonant modes, all spurs near passband of the cascaded DMF can be fully suppressed by optimizing the structure parameters of parasite resonators, which bene- fits from the inherent well-controlled transmission zeros. Experimental results show that the proposed DMF ex- hibits lower insertion loss ,much sharper rate of cutoff and wider spur-free stop band compared with conventional DMF. This design is applicable for spur suppression in wideband communication.
