A modified reduced-order method for RC networks which takes a division-and-conquest strategy is presented.The whole network is partitioned into a set of sub-networks at first,then each of them is reduced by Krylov sub...A modified reduced-order method for RC networks which takes a division-and-conquest strategy is presented.The whole network is partitioned into a set of sub-networks at first,then each of them is reduced by Krylov subspace techniques,and finally all the reduced sub-networks are incorporated together.With some accuracy,this method can reduce the number of both nodes and components of the circuit comparing to the traditional methods which usually only offer a reduced net with less nodes.This can markedly accelerate the sparse-matrix-based simulators whose performance is dominated by the entity of the matrix or the number of components of the circuits.展开更多
Integrating marketing and distribution businesses is crucial for improving the coordination of equipment and the efficient management of multi-energy systems.New energy sources are continuously being connected to dist...Integrating marketing and distribution businesses is crucial for improving the coordination of equipment and the efficient management of multi-energy systems.New energy sources are continuously being connected to distribution grids;this,however,increases the complexity of the information structure of marketing and distribution businesses.The existing unified data model and the coordinated application of marketing and distribution suffer from various drawbacks.As a solution,this paper presents a data model of"one graph of marketing and distribution"and a framework for graph computing,by analyzing the current trends of business and data in the marketing and distribution fields and using graph data theory.Specifically,this work aims to determine the correlation between distribution transformers and marketing users,which is crucial for elucidating the connection between marketing and distribution.In this manner,a novel identification algorithm is proposed based on the collected data for marketing and distribution.Lastly,a forecasting application is developed based on the proposed algorithm to realize the coordinated prediction and consumption of distributed photovoltaic power generation and distribution loads.Furthermore,an operation and maintenance(O&M)knowledge graph reasoning application is developed to improve the intelligent O&M ability of marketing and distribution equipment.展开更多
To increase the efficiency and reliability of the thermodynamics analysis of the hydraulic system, the method based on pseudo-bond graph is introduced. According to the working mechanism of hydraulic components, they ...To increase the efficiency and reliability of the thermodynamics analysis of the hydraulic system, the method based on pseudo-bond graph is introduced. According to the working mechanism of hydraulic components, they can be separated into two categories: capacitive components and resistive components. Then, the thermal-hydraulic pseudo-bond graphs of capacitive C element and resistance R element were developed, based on the conservation of mass and energy. Subsequently, the connection rule for the pseudo-bond graph elements and the method to construct the complete thermal-hydraulic system model were proposed. On the basis of heat transfer analysis of a typical hydraulic circuit containing a piston pump, the lumped parameter mathematical model of the system was given. The good agreement between the simulation results and experimental data demonstrates the validity of the modeling method.展开更多
In the context of the“Two New”initiatives,high school mathematics instruction still grapples with three interlocking problems:knowledge fragmentation,limited cultivation of higher-order thinking,and weak alignment a...In the context of the“Two New”initiatives,high school mathematics instruction still grapples with three interlocking problems:knowledge fragmentation,limited cultivation of higher-order thinking,and weak alignment among teaching,learning,and assessment.To counter these challenges,we propose an Inquiry-Construction Double-Helix model that uses a domain-specific knowledge graph as its cognitive spine.The model interweaves two mutually reinforcing strands-student-driven inquiry and systematic knowledge construction-into a double-helix trajectory analogous to DNA replication.The Inquiry Strand is launched by authentic,situation-based tasks that shepherd students through the complete cycle:question→hypothesis→verification→reflection.The Construction Strand simultaneously externalizes,restructures,and internalizes core disciplinary concepts via visual,hierarchical knowledge graphs.Within the flow of a lesson,the two strands alternately dominate and scaffold each other,securing the co-development of conceptual understanding,procedural fluency,and mathematical literacy.Empirical evidence demonstrates that this model significantly enhances students’systematic knowledge integration,problem-solving transfer ability,and core mathematical competencies,offering a replicable and operable teaching paradigm and practical pathway for deepening high school mathematics classroom reform.展开更多
The article is based on language model,through the cue word engineering and agent thinking method,automatic knowledge extraction,with China accounting standards support to complete the corresponding knowledge map cons...The article is based on language model,through the cue word engineering and agent thinking method,automatic knowledge extraction,with China accounting standards support to complete the corresponding knowledge map construction.Through the way of extracting the accounting entities and their connections in the pattern layer,the data layer is provided for the fine-tuning and optimization of the large model.Studies found that,through the reasonable application of language model,knowledge can be realized in massive financial data neural five effective extracted tuples,and complete accounting knowledge map construction.展开更多
Recognizing essential proteins within bacteriophages is fundamental to uncovering their replication and survival mechanisms and contributes to advances in phage-based antibacterial therapies.Despite notable progress,e...Recognizing essential proteins within bacteriophages is fundamental to uncovering their replication and survival mechanisms and contributes to advances in phage-based antibacterial therapies.Despite notable progress,existing computational techniques struggle to represent the interplay between sequence-derived and structuredependent protein features.To overcome this limitation,we introduce GLM-EP,a unified framework that fuses protein language models with equivariant graph neural networks.Bymerging semantic embeddings extracted from amino acid sequences with geometry-aware graph representations,GLM-EP enables an in-depth depiction of phage proteins and enhances essential protein identification.Evaluation on diverse benchmark datasets confirms that GLM-EP surpasses conventional sequence-based and independent deep-learning methods,yielding higher F1 and AUROC outcomes.Component-wise analysis demonstrates that GCNII,EGNN,and the gated multi-head attention mechanism function in a complementary manner to encode complex molecular attributes.In summary,GLM-EP serves as a robust and efficient tool for bacteriophage genomic analysis and provides valuable methodological perspectives for the discovery of antibiotic-resistance therapeutic targets.The corresponding code repository is available at:https://github.com/MiJia-ID/GLM-EP(accessed on 01 November 2025).展开更多
Drug repurposing offers a promising alternative to traditional drug development and significantly re-duces costs and timelines by identifying new therapeutic uses for existing drugs.However,the current approaches ofte...Drug repurposing offers a promising alternative to traditional drug development and significantly re-duces costs and timelines by identifying new therapeutic uses for existing drugs.However,the current approaches often rely on limited data sources and simplistic hypotheses,which restrict their ability to capture the multi-faceted nature of biological systems.This study introduces adaptive multi-view learning(AMVL),a novel methodology that integrates chemical-induced transcriptional profiles(CTPs),knowledge graph(KG)embeddings,and large language model(LLM)representations,to enhance drug repurposing predictions.AMVL incorporates an innovative similarity matrix expansion strategy and leverages multi-view learning(MVL),matrix factorization,and ensemble optimization techniques to integrate heterogeneous multi-source data.Comprehensive evaluations on benchmark datasets(Fdata-set,Cdataset,and Ydataset)and the large-scale iDrug dataset demonstrate that AMVL outperforms state-of-the-art(SOTA)methods,achieving superior accuracy in predicting drug-disease associations across multiple metrics.Literature-based validation further confirmed the model's predictive capabilities,with seven out of the top ten predictions corroborated by post-2011 evidence.To promote transparency and reproducibility,all data and codes used in this study were open-sourced,providing resources for pro-cessing CTPs,KG,and LLM-based similarity calculations,along with the complete AMVL algorithm and benchmarking procedures.By unifying diverse data modalities,AMVL offers a robust and scalable so-lution for accelerating drug discovery,fostering advancements in translational medicine and integrating multi-omics data.We aim to inspire further innovations in multi-source data integration and support the development of more precise and efficient strategies for advancing drug discovery and translational medicine.展开更多
Objectives:Chemotherapy-induced nausea and vomiting(CINV)is a common adverse effect among breast cancer patients,significantly affecting quality of life.Existing evidence on the prevention,assessment,and management of...Objectives:Chemotherapy-induced nausea and vomiting(CINV)is a common adverse effect among breast cancer patients,significantly affecting quality of life.Existing evidence on the prevention,assessment,and management of this condition is fragmented and inconsistent.This study constructed a CINV knowledge graph using a large language model(LLM)to integrate nursing and medical evidence,thereby supporting systematic clinical decision-making.Methods:A top-down approach was adopted.1)Knowledge base preparation:Nine databases and eight guideline repositories were searched up to October 2024 to include guidelines,evidence summaries,expert consensuses,and systematic reviews screened by two researchers.2)Schema design:Referring to the Unified Medical Language System,Systematized Nomenclature of Medicine-Clinical Terms,and the Nursing Intervention Classification,entity and relation types were defined to build the ontology schema.3)LLM-based extraction and integration:Using the Qwen model under the CRISPE framework,named entity recognition,relation extraction,disambiguation,and fusion were conducted to generate triples and visualize them in Neo4j.Four expert rounds ensured semantic and logical consistency.Model performance was evaluated using precision,recall,F1-score,and 95%confidence interval(95%CI)in Python 3.11.Result:A total of 47 studies were included(18 guidelines,two expert consensuses,two evidence summaries,and 25 systematic reviews).The Qwen model extracted 273 entities and 289 relations;after expert validation,238 entities and 242 relations were retained,forming 244 triples.The ontology comprised nine entity types and eight relation types.The F1-scores for named entity recognition and relation extraction were 82.97(95%CI:0.820,0.839)and 85.54(95%CI:0.844,0.867),respectively.The average node degree was 2.03,with no isolated nodes.Conclusion:The LLM-based CINV knowledge graph achieved structured integration of nursing and medical evidence,offering a novel,data-driven tool to support clinical nursing decision-making and advance intelligent healthcare.展开更多
With the development of the Semantic Web,the number of ontologies grows exponentially and the semantic relationships between ontologies become more and more complex,understanding the true semantics of specific terms o...With the development of the Semantic Web,the number of ontologies grows exponentially and the semantic relationships between ontologies become more and more complex,understanding the true semantics of specific terms or concepts in an ontology is crucial for the matching task.At present,the main challenges facing ontology matching tasks based on representation learning methods are how to improve the embedding quality of ontology knowledge and how to integrate multiple features of ontology efficiently.Therefore,we propose an Ontology Matching Method Based on the Gated Graph Attention Model(OM-GGAT).Firstly,the semantic knowledge related to concepts in the ontology is encoded into vectors using the OWL2Vec^(*)method,and the relevant path information from the root node to the concept is embedded to understand better the true meaning of the concept itself and the relationship between concepts.Secondly,the ontology is transformed into the corresponding graph structure according to the semantic relation.Then,when extracting the features of the ontology graph nodes,different attention weights are assigned to each adjacent node of the central concept with the help of the attention mechanism idea.Finally,gated networks are designed to further fuse semantic and structural embedding representations efficiently.To verify the effectiveness of the proposed method,comparative experiments on matching tasks were carried out on public datasets.The results show that the OM-GGAT model can effectively improve the efficiency of ontology matching.展开更多
As large language models(LLMs)continue to demonstrate their potential in handling complex tasks,their value in knowledge-intensive industrial scenarios is becoming increasingly evident.Fault diagnosis,a critical domai...As large language models(LLMs)continue to demonstrate their potential in handling complex tasks,their value in knowledge-intensive industrial scenarios is becoming increasingly evident.Fault diagnosis,a critical domain in the industrial sector,has long faced the dual challenges of managing vast amounts of experiential knowledge and improving human-machine collaboration efficiency.Traditional fault diagnosis systems,which are primarily based on expert systems,suffer from three major limitations:(1)ineffective organization of fault diagnosis knowledge,(2)lack of adaptability between static knowledge frameworks and dynamic engineering environments,and(3)difficulties in integrating expert knowledge with real-time data streams.These systemic shortcomings restrict the ability of conventional approaches to handle uncertainty.In this study,we proposed an intelligent computer numerical control(CNC)fault diagnosis system,integrating LLMs with knowledge graph(KG).First,we constructed a comprehensive KG that consolidated multi-source data for structured representation.Second,we designed a retrievalaugmented generation(RAG)framework leveraging the KG to support multi-turn interactive fault diagnosis while incorporating real-time engineering data into the decision-making process.Finally,we introduced a learning mechanism to facilitate dynamic knowledge updates.The experimental results demonstrated that our system significantly improved fault diagnosis accuracy,outperforming engineers with two years of professional experience on our constructed benchmark datasets.By integrating LLMs and KG,our framework surpassed the limitations of traditional expert systems rooted in symbolic reasoning,offering a novel approach to addressing the cognitive paradox of unstructured knowledge modeling and dynamic environment adaptation in industrial settings.展开更多
Under the paradigm of Industry 5.0,intelligent manufacturing transcends mere efficiency enhancement by emphasizing human-machine collaboration,where human expertise plays a central role in assembly processes.Despite a...Under the paradigm of Industry 5.0,intelligent manufacturing transcends mere efficiency enhancement by emphasizing human-machine collaboration,where human expertise plays a central role in assembly processes.Despite advancements in intelligent and digital technologies,assembly process design still heavily relies on manual knowledge reuse,and inefficiencies and inconsistent quality in process documentation are caused.To address the aforementioned issues,this paper proposes a knowledge push method of complex product assembly process design based on distillation model-based dynamically enhanced graph and Bayesian network.First,an initial knowledge graph is constructed using a BERT-BiLSTM-CRF model trained with integrated human expertise and a fine-tuned large language model.Then,a confidence-based dynamic weighted fusion strategy is employed to achieve dynamic incremental construction of the knowledge graph with low resource consumption.Subsequently,a Bayesian network model is constructed based on the relationships between assembly components,assembly features,and operations.Bayesian network reasoning is used to push assembly process knowledge under different design requirements.Finally,the feasibility of the Bayesian network construction method and the effectiveness of Bayesian network reasoning are verified through a specific example,significantly improving the utilization of assembly process knowledge and the efficiency of assembly process design.展开更多
The development and the revolution of nanotechnology require more and effective methods to accurately estimating the timing analysis for any CMOS transistor level circuit. Many researches attempted to resolve the timi...The development and the revolution of nanotechnology require more and effective methods to accurately estimating the timing analysis for any CMOS transistor level circuit. Many researches attempted to resolve the timing analysis, but the best method found till the moment is the Static Timing Analysis (STA). It is considered the best solution because of its accuracy and fast run time. Transistor level models are mandatory required for the best estimating methods, since these take into consideration all analysis scenarios to overcome problems of multiple-input switching, false paths and high stacks that are found in classic CMOS gates. In this paper, transistor level graph model is proposed to describe the behavior of CMOS circuits under predictive Nanotechnology SPICE parameters. This model represents the transistor in the CMOS circuit as nodes in the graph regardless of its positions in the gates to accurately estimating the timing analysis rather than inaccurate estimating which caused by the false paths at the gate level. Accurate static timing analysis is estimated using the model proposed in this paper. Building on the proposed model and the graph theory concepts, new algorithms are proposed and simulated to compute transistor timing analysis using RC model. Simulation results show the validity of the proposed graph model and its algorithms by using predictive Nano-Technology SPICE parameters for the tested technology. An important and effective extension has been achieved in this paper for a one that was published in international conference.展开更多
The increasing complexity of China’s electricity market creates substantial challenges for settlement automation,data consistency,and operational scalability.Existing provincial settlement systems are fragmented,lack...The increasing complexity of China’s electricity market creates substantial challenges for settlement automation,data consistency,and operational scalability.Existing provincial settlement systems are fragmented,lack a unified data structure,and depend heavily on manual intervention to process high-frequency and retroactive transactions.To address these limitations,a graph-based unified settlement framework is proposed to enhance automation,flexibility,and adaptability in electricity market settlements.A flexible attribute-graph model is employed to represent heterogeneousmulti-market data,enabling standardized integration,rapid querying,and seamless adaptation to evolving business requirements.An extensible operator library is designed to support configurable settlement rules,and a suite of modular tools—including dataset generation,formula configuration,billing templates,and task scheduling—facilitates end-to-end automated settlement processing.A robust refund-clearing mechanism is further incorporated,utilizing sandbox execution,data-version snapshots,dynamic lineage tracing,and real-time changecapture technologies to enable rapid and accurate recalculations under dynamic policy and data revisions.Case studies based on real-world data from regional Chinese markets validate the effectiveness of the proposed approach,demonstrating marked improvements in computational efficiency,system robustness,and automation.Moreover,enhanced settlement accuracy and high temporal granularity improve price-signal fidelity,promote cost-reflective tariffs,and incentivize energy-efficient and demand-responsive behavior among market participants.The method not only supports equitable and transparent market operations but also provides a generalizable,scalable foundation for modern electricity settlement platforms in increasingly complex and dynamic market environments.展开更多
Temporal knowledge graph completion(TKGC),which merges temporal information into traditional static knowledge graph completion(SKGC),has garnered increasing attention recently.Among numerous emerging approaches,transl...Temporal knowledge graph completion(TKGC),which merges temporal information into traditional static knowledge graph completion(SKGC),has garnered increasing attention recently.Among numerous emerging approaches,translation-based embedding models constitute a prominent approach in TKGC research.However,existing translation-based methods typically incorporate timestamps into entities or relations,rather than utilizing them independently.This practice fails to fully exploit the rich semantics inherent in temporal information,thereby weakening the expressive capability of models.To address this limitation,we propose embedding timestamps,like entities and relations,in one or more dedicated semantic spaces.After projecting all embeddings into a shared space,we use the relation-timestamp pair instead of the conventional relation embedding as the translation vector between head and tail entities.Our method elevates timestamps to the same representational significance as entities and relations.Based on this strategy,we introduce two novel translation-based embedding models:TE-TransR and TE-TransT.With the independent representation of timestamps,our method not only enhances capabilities in link prediction but also facilitates a relatively underexplored task,namely time prediction.To further bolster the precision and reliability of time prediction,we introduce a granular,time unit-based timestamp setting and a relation-specific evaluation protocol.Extensive experiments demonstrate that our models achieve strong performance on link prediction benchmarks,with TE-TransR outperforming existing baselines in the time prediction task.展开更多
Due to the complex structural hierarchy,with deeply nested associative relations between entities such as equipment,specifications,and business processes,intelligent power grid engineering is challenging.Meanwhile,lim...Due to the complex structural hierarchy,with deeply nested associative relations between entities such as equipment,specifications,and business processes,intelligent power grid engineering is challenging.Meanwhile,limited by the fragmented data and loss of contextual information,the generated reports are prone to the problems such as content redundancy and omission of critical information,failing to meet the demands of efficient decision-making and accurate management in modern power systems.To address these issues,this paper proposes a knowledge graph(KG)-enhanced framework to automatically generate electric power engineering reports.In the KG construction phase,a feature-fused entity recognition model named BERT-BiLSTM-CRF is adopted to improve the accuracy of entity recognition in scenarios involving power engineering professional terminology,thereby solving the problem of ambiguous entity boundaries in traditional models;then a BERT-attention relation extraction model is proposed to enhance the completeness of extracting complex hierarchical and implicit relations in power grid data.In the report generation phase,an improved Transformer architecture is adopted to accurately transform structured knowledge into natural language reports that comply with engineering specifications,addressing the issue of semantic inconsistency caused by the loss of structural information in existing models.By validating with real-world projects,the results show that the proposed framework significantly outperforms existing baseline models in entity recognition,confirming its superiority and applicability in practical engineering.展开更多
Based on the idea that modules are independent of machines, different combinations of modules and machines result in different configurations and the system performances differ under different configurations, a kind o...Based on the idea that modules are independent of machines, different combinations of modules and machines result in different configurations and the system performances differ under different configurations, a kind of cyclic reconfigurable flow shops are proposed for the new manufacturing paradigm-reconfigurable manufacturing system. The cyclic reconfigurable flow shop is modeled as a timed event graph. The optimal configuration is defined as the one under which the cyclic reconfigurable flow shop functions with the minimum cycle time and the minimum number of pallets. The optimal configuration, the minimum cycle time and the minimum number of pallets can be obtained in two steps.展开更多
文摘A modified reduced-order method for RC networks which takes a division-and-conquest strategy is presented.The whole network is partitioned into a set of sub-networks at first,then each of them is reduced by Krylov subspace techniques,and finally all the reduced sub-networks are incorporated together.With some accuracy,this method can reduce the number of both nodes and components of the circuit comparing to the traditional methods which usually only offer a reduced net with less nodes.This can markedly accelerate the sparse-matrix-based simulators whose performance is dominated by the entity of the matrix or the number of components of the circuits.
基金This work was supported by the National Key R&D Program of China(2020YFB0905900).
文摘Integrating marketing and distribution businesses is crucial for improving the coordination of equipment and the efficient management of multi-energy systems.New energy sources are continuously being connected to distribution grids;this,however,increases the complexity of the information structure of marketing and distribution businesses.The existing unified data model and the coordinated application of marketing and distribution suffer from various drawbacks.As a solution,this paper presents a data model of"one graph of marketing and distribution"and a framework for graph computing,by analyzing the current trends of business and data in the marketing and distribution fields and using graph data theory.Specifically,this work aims to determine the correlation between distribution transformers and marketing users,which is crucial for elucidating the connection between marketing and distribution.In this manner,a novel identification algorithm is proposed based on the collected data for marketing and distribution.Lastly,a forecasting application is developed based on the proposed algorithm to realize the coordinated prediction and consumption of distributed photovoltaic power generation and distribution loads.Furthermore,an operation and maintenance(O&M)knowledge graph reasoning application is developed to improve the intelligent O&M ability of marketing and distribution equipment.
基金Project(51175518)supported by the National Natural Science Foundation of China
文摘To increase the efficiency and reliability of the thermodynamics analysis of the hydraulic system, the method based on pseudo-bond graph is introduced. According to the working mechanism of hydraulic components, they can be separated into two categories: capacitive components and resistive components. Then, the thermal-hydraulic pseudo-bond graphs of capacitive C element and resistance R element were developed, based on the conservation of mass and energy. Subsequently, the connection rule for the pseudo-bond graph elements and the method to construct the complete thermal-hydraulic system model were proposed. On the basis of heat transfer analysis of a typical hydraulic circuit containing a piston pump, the lumped parameter mathematical model of the system was given. The good agreement between the simulation results and experimental data demonstrates the validity of the modeling method.
文摘In the context of the“Two New”initiatives,high school mathematics instruction still grapples with three interlocking problems:knowledge fragmentation,limited cultivation of higher-order thinking,and weak alignment among teaching,learning,and assessment.To counter these challenges,we propose an Inquiry-Construction Double-Helix model that uses a domain-specific knowledge graph as its cognitive spine.The model interweaves two mutually reinforcing strands-student-driven inquiry and systematic knowledge construction-into a double-helix trajectory analogous to DNA replication.The Inquiry Strand is launched by authentic,situation-based tasks that shepherd students through the complete cycle:question→hypothesis→verification→reflection.The Construction Strand simultaneously externalizes,restructures,and internalizes core disciplinary concepts via visual,hierarchical knowledge graphs.Within the flow of a lesson,the two strands alternately dominate and scaffold each other,securing the co-development of conceptual understanding,procedural fluency,and mathematical literacy.Empirical evidence demonstrates that this model significantly enhances students’systematic knowledge integration,problem-solving transfer ability,and core mathematical competencies,offering a replicable and operable teaching paradigm and practical pathway for deepening high school mathematics classroom reform.
文摘The article is based on language model,through the cue word engineering and agent thinking method,automatic knowledge extraction,with China accounting standards support to complete the corresponding knowledge map construction.Through the way of extracting the accounting entities and their connections in the pattern layer,the data layer is provided for the fine-tuning and optimization of the large model.Studies found that,through the reasonable application of language model,knowledge can be realized in massive financial data neural five effective extracted tuples,and complete accounting knowledge map construction.
基金supported in part by funds from the Ministry of Science and Technology(2022FY101104).
文摘Recognizing essential proteins within bacteriophages is fundamental to uncovering their replication and survival mechanisms and contributes to advances in phage-based antibacterial therapies.Despite notable progress,existing computational techniques struggle to represent the interplay between sequence-derived and structuredependent protein features.To overcome this limitation,we introduce GLM-EP,a unified framework that fuses protein language models with equivariant graph neural networks.Bymerging semantic embeddings extracted from amino acid sequences with geometry-aware graph representations,GLM-EP enables an in-depth depiction of phage proteins and enhances essential protein identification.Evaluation on diverse benchmark datasets confirms that GLM-EP surpasses conventional sequence-based and independent deep-learning methods,yielding higher F1 and AUROC outcomes.Component-wise analysis demonstrates that GCNII,EGNN,and the gated multi-head attention mechanism function in a complementary manner to encode complex molecular attributes.In summary,GLM-EP serves as a robust and efficient tool for bacteriophage genomic analysis and provides valuable methodological perspectives for the discovery of antibiotic-resistance therapeutic targets.The corresponding code repository is available at:https://github.com/MiJia-ID/GLM-EP(accessed on 01 November 2025).
基金supported by the National Natural Science Foundation of China(Grant No.:62101087)the China Postdoctoral Science Foundation(Grant No.:2021MD703942)+2 种基金the Chongqing Postdoctoral Research Project Special Funding,China(Grant No.:2021XM2016)the Science Foundation of Chongqing Municipal Commission of Education,China(Grant No.:KJQN202100642)the Chongqing Natural Science Foundation,China(Grant No.:cstc2021jcyj-msxmX0834).
文摘Drug repurposing offers a promising alternative to traditional drug development and significantly re-duces costs and timelines by identifying new therapeutic uses for existing drugs.However,the current approaches often rely on limited data sources and simplistic hypotheses,which restrict their ability to capture the multi-faceted nature of biological systems.This study introduces adaptive multi-view learning(AMVL),a novel methodology that integrates chemical-induced transcriptional profiles(CTPs),knowledge graph(KG)embeddings,and large language model(LLM)representations,to enhance drug repurposing predictions.AMVL incorporates an innovative similarity matrix expansion strategy and leverages multi-view learning(MVL),matrix factorization,and ensemble optimization techniques to integrate heterogeneous multi-source data.Comprehensive evaluations on benchmark datasets(Fdata-set,Cdataset,and Ydataset)and the large-scale iDrug dataset demonstrate that AMVL outperforms state-of-the-art(SOTA)methods,achieving superior accuracy in predicting drug-disease associations across multiple metrics.Literature-based validation further confirmed the model's predictive capabilities,with seven out of the top ten predictions corroborated by post-2011 evidence.To promote transparency and reproducibility,all data and codes used in this study were open-sourced,providing resources for pro-cessing CTPs,KG,and LLM-based similarity calculations,along with the complete AMVL algorithm and benchmarking procedures.By unifying diverse data modalities,AMVL offers a robust and scalable so-lution for accelerating drug discovery,fostering advancements in translational medicine and integrating multi-omics data.We aim to inspire further innovations in multi-source data integration and support the development of more precise and efficient strategies for advancing drug discovery and translational medicine.
基金supported by Education and Research Project of Fujian Province Young and Middle-aged Teachers(JAT241035)High-level Talent Project of Fujian Medical University(XRCZX2024036)。
文摘Objectives:Chemotherapy-induced nausea and vomiting(CINV)is a common adverse effect among breast cancer patients,significantly affecting quality of life.Existing evidence on the prevention,assessment,and management of this condition is fragmented and inconsistent.This study constructed a CINV knowledge graph using a large language model(LLM)to integrate nursing and medical evidence,thereby supporting systematic clinical decision-making.Methods:A top-down approach was adopted.1)Knowledge base preparation:Nine databases and eight guideline repositories were searched up to October 2024 to include guidelines,evidence summaries,expert consensuses,and systematic reviews screened by two researchers.2)Schema design:Referring to the Unified Medical Language System,Systematized Nomenclature of Medicine-Clinical Terms,and the Nursing Intervention Classification,entity and relation types were defined to build the ontology schema.3)LLM-based extraction and integration:Using the Qwen model under the CRISPE framework,named entity recognition,relation extraction,disambiguation,and fusion were conducted to generate triples and visualize them in Neo4j.Four expert rounds ensured semantic and logical consistency.Model performance was evaluated using precision,recall,F1-score,and 95%confidence interval(95%CI)in Python 3.11.Result:A total of 47 studies were included(18 guidelines,two expert consensuses,two evidence summaries,and 25 systematic reviews).The Qwen model extracted 273 entities and 289 relations;after expert validation,238 entities and 242 relations were retained,forming 244 triples.The ontology comprised nine entity types and eight relation types.The F1-scores for named entity recognition and relation extraction were 82.97(95%CI:0.820,0.839)and 85.54(95%CI:0.844,0.867),respectively.The average node degree was 2.03,with no isolated nodes.Conclusion:The LLM-based CINV knowledge graph achieved structured integration of nursing and medical evidence,offering a novel,data-driven tool to support clinical nursing decision-making and advance intelligent healthcare.
基金supported by the National Natural Science Foundation of China(grant numbers 62267005 and 42365008)the Guangxi Collaborative Innovation Center of Multi-Source Information Integration and Intelligent Processing.
文摘With the development of the Semantic Web,the number of ontologies grows exponentially and the semantic relationships between ontologies become more and more complex,understanding the true semantics of specific terms or concepts in an ontology is crucial for the matching task.At present,the main challenges facing ontology matching tasks based on representation learning methods are how to improve the embedding quality of ontology knowledge and how to integrate multiple features of ontology efficiently.Therefore,we propose an Ontology Matching Method Based on the Gated Graph Attention Model(OM-GGAT).Firstly,the semantic knowledge related to concepts in the ontology is encoded into vectors using the OWL2Vec^(*)method,and the relevant path information from the root node to the concept is embedded to understand better the true meaning of the concept itself and the relationship between concepts.Secondly,the ontology is transformed into the corresponding graph structure according to the semantic relation.Then,when extracting the features of the ontology graph nodes,different attention weights are assigned to each adjacent node of the central concept with the help of the attention mechanism idea.Finally,gated networks are designed to further fuse semantic and structural embedding representations efficiently.To verify the effectiveness of the proposed method,comparative experiments on matching tasks were carried out on public datasets.The results show that the OM-GGAT model can effectively improve the efficiency of ontology matching.
基金funded by the National Natural Science Foundation of China(72104224,L2424237,71974107,L2224059,L2124002,and 91646102)the Beijing Natural Science Foundation(9232015)+4 种基金the Beijing Social Science Foundation(24GLC058)the Construction Project of China Knowledge Center for Engineering Sciences and Technology(CKCEST-2023-1-7)the MOE(Ministry of Education in China)Project of Humanities and Social Sciences(16JDGC011)the Tsinghua University Initiative Scientific Research Program(2019Z02CAU)the Tsinghua University Project of Volvo-Supported Green Economy and Sustainable Development(20183910020)。
文摘As large language models(LLMs)continue to demonstrate their potential in handling complex tasks,their value in knowledge-intensive industrial scenarios is becoming increasingly evident.Fault diagnosis,a critical domain in the industrial sector,has long faced the dual challenges of managing vast amounts of experiential knowledge and improving human-machine collaboration efficiency.Traditional fault diagnosis systems,which are primarily based on expert systems,suffer from three major limitations:(1)ineffective organization of fault diagnosis knowledge,(2)lack of adaptability between static knowledge frameworks and dynamic engineering environments,and(3)difficulties in integrating expert knowledge with real-time data streams.These systemic shortcomings restrict the ability of conventional approaches to handle uncertainty.In this study,we proposed an intelligent computer numerical control(CNC)fault diagnosis system,integrating LLMs with knowledge graph(KG).First,we constructed a comprehensive KG that consolidated multi-source data for structured representation.Second,we designed a retrievalaugmented generation(RAG)framework leveraging the KG to support multi-turn interactive fault diagnosis while incorporating real-time engineering data into the decision-making process.Finally,we introduced a learning mechanism to facilitate dynamic knowledge updates.The experimental results demonstrated that our system significantly improved fault diagnosis accuracy,outperforming engineers with two years of professional experience on our constructed benchmark datasets.By integrating LLMs and KG,our framework surpassed the limitations of traditional expert systems rooted in symbolic reasoning,offering a novel approach to addressing the cognitive paradox of unstructured knowledge modeling and dynamic environment adaptation in industrial settings.
基金Supported by National Key Research and Development Program(Grant No.2024YFB3312700)National Natural Science Foundation of China(Grant No.52405541)the Changzhou Municipal Sci&Tech Program(Grant No.CJ20241131)。
文摘Under the paradigm of Industry 5.0,intelligent manufacturing transcends mere efficiency enhancement by emphasizing human-machine collaboration,where human expertise plays a central role in assembly processes.Despite advancements in intelligent and digital technologies,assembly process design still heavily relies on manual knowledge reuse,and inefficiencies and inconsistent quality in process documentation are caused.To address the aforementioned issues,this paper proposes a knowledge push method of complex product assembly process design based on distillation model-based dynamically enhanced graph and Bayesian network.First,an initial knowledge graph is constructed using a BERT-BiLSTM-CRF model trained with integrated human expertise and a fine-tuned large language model.Then,a confidence-based dynamic weighted fusion strategy is employed to achieve dynamic incremental construction of the knowledge graph with low resource consumption.Subsequently,a Bayesian network model is constructed based on the relationships between assembly components,assembly features,and operations.Bayesian network reasoning is used to push assembly process knowledge under different design requirements.Finally,the feasibility of the Bayesian network construction method and the effectiveness of Bayesian network reasoning are verified through a specific example,significantly improving the utilization of assembly process knowledge and the efficiency of assembly process design.
文摘The development and the revolution of nanotechnology require more and effective methods to accurately estimating the timing analysis for any CMOS transistor level circuit. Many researches attempted to resolve the timing analysis, but the best method found till the moment is the Static Timing Analysis (STA). It is considered the best solution because of its accuracy and fast run time. Transistor level models are mandatory required for the best estimating methods, since these take into consideration all analysis scenarios to overcome problems of multiple-input switching, false paths and high stacks that are found in classic CMOS gates. In this paper, transistor level graph model is proposed to describe the behavior of CMOS circuits under predictive Nanotechnology SPICE parameters. This model represents the transistor in the CMOS circuit as nodes in the graph regardless of its positions in the gates to accurately estimating the timing analysis rather than inaccurate estimating which caused by the false paths at the gate level. Accurate static timing analysis is estimated using the model proposed in this paper. Building on the proposed model and the graph theory concepts, new algorithms are proposed and simulated to compute transistor timing analysis using RC model. Simulation results show the validity of the proposed graph model and its algorithms by using predictive Nano-Technology SPICE parameters for the tested technology. An important and effective extension has been achieved in this paper for a one that was published in international conference.
基金funded by the Science and Technology Project of State Grid Corporation of China(5108-202355437A-3-2-ZN).
文摘The increasing complexity of China’s electricity market creates substantial challenges for settlement automation,data consistency,and operational scalability.Existing provincial settlement systems are fragmented,lack a unified data structure,and depend heavily on manual intervention to process high-frequency and retroactive transactions.To address these limitations,a graph-based unified settlement framework is proposed to enhance automation,flexibility,and adaptability in electricity market settlements.A flexible attribute-graph model is employed to represent heterogeneousmulti-market data,enabling standardized integration,rapid querying,and seamless adaptation to evolving business requirements.An extensible operator library is designed to support configurable settlement rules,and a suite of modular tools—including dataset generation,formula configuration,billing templates,and task scheduling—facilitates end-to-end automated settlement processing.A robust refund-clearing mechanism is further incorporated,utilizing sandbox execution,data-version snapshots,dynamic lineage tracing,and real-time changecapture technologies to enable rapid and accurate recalculations under dynamic policy and data revisions.Case studies based on real-world data from regional Chinese markets validate the effectiveness of the proposed approach,demonstrating marked improvements in computational efficiency,system robustness,and automation.Moreover,enhanced settlement accuracy and high temporal granularity improve price-signal fidelity,promote cost-reflective tariffs,and incentivize energy-efficient and demand-responsive behavior among market participants.The method not only supports equitable and transparent market operations but also provides a generalizable,scalable foundation for modern electricity settlement platforms in increasingly complex and dynamic market environments.
基金supported by the National Natural Science Foundation of China under Grant No.72293575.
文摘Temporal knowledge graph completion(TKGC),which merges temporal information into traditional static knowledge graph completion(SKGC),has garnered increasing attention recently.Among numerous emerging approaches,translation-based embedding models constitute a prominent approach in TKGC research.However,existing translation-based methods typically incorporate timestamps into entities or relations,rather than utilizing them independently.This practice fails to fully exploit the rich semantics inherent in temporal information,thereby weakening the expressive capability of models.To address this limitation,we propose embedding timestamps,like entities and relations,in one or more dedicated semantic spaces.After projecting all embeddings into a shared space,we use the relation-timestamp pair instead of the conventional relation embedding as the translation vector between head and tail entities.Our method elevates timestamps to the same representational significance as entities and relations.Based on this strategy,we introduce two novel translation-based embedding models:TE-TransR and TE-TransT.With the independent representation of timestamps,our method not only enhances capabilities in link prediction but also facilitates a relatively underexplored task,namely time prediction.To further bolster the precision and reliability of time prediction,we introduce a granular,time unit-based timestamp setting and a relation-specific evaluation protocol.Extensive experiments demonstrate that our models achieve strong performance on link prediction benchmarks,with TE-TransR outperforming existing baselines in the time prediction task.
基金supported by State Grid Shanghai Economic Research Institute under Grant No.SGTYHT/23-JS-004.
文摘Due to the complex structural hierarchy,with deeply nested associative relations between entities such as equipment,specifications,and business processes,intelligent power grid engineering is challenging.Meanwhile,limited by the fragmented data and loss of contextual information,the generated reports are prone to the problems such as content redundancy and omission of critical information,failing to meet the demands of efficient decision-making and accurate management in modern power systems.To address these issues,this paper proposes a knowledge graph(KG)-enhanced framework to automatically generate electric power engineering reports.In the KG construction phase,a feature-fused entity recognition model named BERT-BiLSTM-CRF is adopted to improve the accuracy of entity recognition in scenarios involving power engineering professional terminology,thereby solving the problem of ambiguous entity boundaries in traditional models;then a BERT-attention relation extraction model is proposed to enhance the completeness of extracting complex hierarchical and implicit relations in power grid data.In the report generation phase,an improved Transformer architecture is adopted to accurately transform structured knowledge into natural language reports that comply with engineering specifications,addressing the issue of semantic inconsistency caused by the loss of structural information in existing models.By validating with real-world projects,the results show that the proposed framework significantly outperforms existing baseline models in entity recognition,confirming its superiority and applicability in practical engineering.
基金Supported by National Key Fundamental Research and Development Project of P. R. China (2002CB312200)
文摘Based on the idea that modules are independent of machines, different combinations of modules and machines result in different configurations and the system performances differ under different configurations, a kind of cyclic reconfigurable flow shops are proposed for the new manufacturing paradigm-reconfigurable manufacturing system. The cyclic reconfigurable flow shop is modeled as a timed event graph. The optimal configuration is defined as the one under which the cyclic reconfigurable flow shop functions with the minimum cycle time and the minimum number of pallets. The optimal configuration, the minimum cycle time and the minimum number of pallets can be obtained in two steps.
