BACKGROUND Cognitive frailty and depression are prevalent among the elderly,significantly impairing physical and cognitive functions,psychological well-being,and quality of life.Effective interventions are essential t...BACKGROUND Cognitive frailty and depression are prevalent among the elderly,significantly impairing physical and cognitive functions,psychological well-being,and quality of life.Effective interventions are essential to mitigate these adverse effects and enhance overall health outcomes in this population.AIM To evaluate the effects of exercise-cognitive dual-task training on frailty,cognitive function,psychological status,and quality of life in elderly patients with cognitive frailty and depression.METHODS A retrospective study was conducted on 130 patients with cognitive frailty and depression admitted between December 2021 and December 2023.Patients were divided into a control group receiving routine intervention and an observation group undergoing exercise-cognitive dual-task training in addition to routine care.Frailty,cognitive function,balance and gait,psychological status,and quality of life were assessed before and after the intervention.RESULTS After the intervention,the frailty score of the observation group was(5.32±0.69),lower than that of the control group(5.71±0.55).The Montreal cognitive assessment basic scale score in the observation group was(24.06±0.99),higher than the control group(23.43±1.40).The performance oriented mobility assessment score in the observation group was(21.81±1.24),higher than the control group(21.15±1.26).The self-efficacy in the observation group was(28.27±2.66),higher than the control group(30.05±2.66).The anxiety score in the hospital anxiety and depression scale(HADS)for the observation group was(5.86±0.68),lower than the control group(6.21±0.64).The depression score in the HADS for the observation group was(5.67±0.75),lower than the control group(6.27±0.92).Additionally,the scores for each dimension of the 36-item short form survey in the observation group were higher than those in the control group,with statistically significant differences(P<0.05).CONCLUSION Exercise-cognitive dual-task training is beneficial for improving frailty,enhancing cognitive function,and improving psychological status and quality of life in elderly patients with cognitive frailty and depression.展开更多
Emotion recognition plays a crucial role in various fields and is a key task in natural language processing (NLP). The objective is to identify and interpret emotional expressions in text. However, traditional emotion...Emotion recognition plays a crucial role in various fields and is a key task in natural language processing (NLP). The objective is to identify and interpret emotional expressions in text. However, traditional emotion recognition approaches often struggle in few-shot cross-domain scenarios due to their limited capacity to generalize semantic features across different domains. Additionally, these methods face challenges in accurately capturing complex emotional states, particularly those that are subtle or implicit. To overcome these limitations, we introduce a novel approach called Dual-Task Contrastive Meta-Learning (DTCML). This method combines meta-learning and contrastive learning to improve emotion recognition. Meta-learning enhances the model’s ability to generalize to new emotional tasks, while instance contrastive learning further refines the model by distinguishing unique features within each category, enabling it to better differentiate complex emotional expressions. Prototype contrastive learning, in turn, helps the model address the semantic complexity of emotions across different domains, enabling the model to learn fine-grained emotions expression. By leveraging dual tasks, DTCML learns from two domains simultaneously, the model is encouraged to learn more diverse and generalizable emotions features, thereby improving its cross-domain adaptability and robustness, and enhancing its generalization ability. We evaluated the performance of DTCML across four cross-domain settings, and the results show that our method outperforms the best baseline by 5.88%, 12.04%, 8.49%, and 8.40% in terms of accuracy.展开更多
BACKGROUND Research has consistently demonstrated that patients with major depressive disorder(MDD)exhibit attentional switching dysfunction,and the dual-task paradigm has emerged as a valuable tool for probing cognit...BACKGROUND Research has consistently demonstrated that patients with major depressive disorder(MDD)exhibit attentional switching dysfunction,and the dual-task paradigm has emerged as a valuable tool for probing cognitive deficits.However,the neuroelectrophysiological mechanism underlying this deficit has not been clarified.AIM To investigate the event-related potential(ERP)characteristics of attentional switching dysfunction and further explore the neuroelectrophysiological mechanism of the cognitive processing deficits underlying attentional switching dysfunction in MDD.METHODS The participants included 29 MDD patients and 29 healthy controls(HCs).The ERPs of the participants were measured while they performed the dual-task para digm.The behavioral and ERP N100,P200,P300,and late positive potential(LPP)data were analyzed.RESULTS This study revealed greater accuracy in HCs and slower reaction times(RTs)in MDD patients.Angry facial pictures led to lower accuracy.The results also revealed shorter RTs for happy facial pictures and the longest RTs for the 500-ms stimulus onset asynchrony.With respect to ERP characteristics,happy facial pictures and neutral facial pictures evoked higher amplitudes.The N100,P200,P300,and LPP amplitudes at Pz were the highest.MDD patients had lower P200 mean amplitudes and LPP amplitudes than HCs did.CONCLUSION In conclusion,MDD patients exhibited abnormal ERP characteristics evoked by the dual-task paradigm,which could be the neural correlates of the known abnormalities in attentional switching in patients with MDD.These results provide valuable insights into the understanding of the neural mechanisms of attentional switching function and may guide targeted interventions in patients with MDD.展开更多
The off situ accurate reconstruction of the core neutron field is an important step in realizing real-time reactor monitoring.The existing off situ reconstruction method of the neutron field is only applicable to case...The off situ accurate reconstruction of the core neutron field is an important step in realizing real-time reactor monitoring.The existing off situ reconstruction method of the neutron field is only applicable to cases wherein a single region changes at a specified location of the core.However,when the neutron field changes are complex,the accurate identification of the individual changed regions becomes challenging,which seriously affects the accuracy and stability of the neutron field recon-struction.Therefore,this study proposed a dual-task hybrid network architecture(DTHNet)for off situ reconstruction of the core neutron field,which trained the outermost assembly reconstruction task and the core reconstruction task jointly such that the former could assist the latter in the reconstruction of the core neutron field under core complex changes.Furthermore,to exploit the characteristics of the ex-core detection signals,this study designed a global-local feature upsampling module that efficiently distributed the ex-core detection signals to each reconstruction unit to improve the accuracy and stability of reconstruction.Reconstruction experiments were performed on the simulation datasets of the CLEAR-I reactor to verify the accuracy and stability of the proposed method.The results showed that when the location uncertainty of a single region did not exceed nine and the number of multiple changed regions did not exceed five.Further,the reconstructed ARD was within 2%,RD_(max)was maintained within 17.5%,and the number of RD≥10%was maintained within 10.Furthermore,when the noise interference of the ex-core detection signals was within±2%,although the average number of RD≥10%increased to 16,the average ARD was still within in 2%,and the average RD_(max)was within 22%.Collectively,these results show that,theoretically,the DTHNet can accurately and stably reconstruct most of the neutron field under certain complex core changes.展开更多
<strong>Objective</strong>: Purpose of this study was to investigate the behavioral and brain activity impairments in patients after moderate traumatic brain injury (mTBI) in comparison with the normal ran...<strong>Objective</strong>: Purpose of this study was to investigate the behavioral and brain activity impairments in patients after moderate traumatic brain injury (mTBI) in comparison with the normal ranges while dual-tasks performing. We would like to evaluate dual-tasking as diagnostic and rehabilitation tool and to test hypothesis of brain aging after mTBI. <strong>Material and Methods</strong>: Electroencephalographic (EEG), stabilographic and clinical study was performed in 11 patients (mean age 28.8 ± 8.4 years) for up to 1 - 12 months after a mTBI in comparison with 17 healthy subjects (26.7 ± 5.1 years). All the participants performed two motor and two cognitive tasks presented separately, and simultaneously (dual-tasking). <strong>Results</strong>: Clinical examination revealed predominantly cognitive deficit in mTBI patients with intact postural control. EEG data demonstrated coherence decrease for slow (delta-theta) rhythms in frontal-temporal areas predominantly for left hemisphere during cognitive tasks performance. In contrast, EEG coherence for slow spectral bands increased in the same areas in healthy volunteers. EEG coherence increased for fast spectral bands—alpha2 and beta, predominantly in right hemisphere while both healthy adults and patients performed motor components of dual tasks. Rehabilitation course with dual tasks, led to a predominant reduction in cognitive deficits, and EEG coherence increases at the frontal-temporal areas of the left hemisphere. <strong>Conclusions</strong>: Dual-tasks may be used as diagnostic tool in patients after mTBI. This approach demonstrates predominant cognitive deficit, and left hemispheric dysfunction in patients similar to elderly persons and support the hypothesis of brain aging after TBI. Pilot studies also suggested rehabilitation effect of dual-tasking in mTBI patients.展开更多
Stuttering is a common neurological deficit and its underlying cognitive mechanisms are a matter of debate, with evidence suggesting abnormal modulation between speech encoding and other cognitive components. Previous...Stuttering is a common neurological deficit and its underlying cognitive mechanisms are a matter of debate, with evidence suggesting abnormal modulation between speech encoding and other cognitive components. Previous studies have mainly used single task experiments to investigate the disturbance of language production. It is unclear whether there is abnormal interaction between the three language tasks （orthographic, phonological and semantic judgment） in stuttering patients. This study used dual tasks and manipulated the stimulus onset asynchrony （SOA） between tasks 1 and 2 and the nature of the second task, including orthographic, phonological, and semantic judgments. The results showed that the performance records of orthographic judgment, phonological judgment, and semantic judgment were significantly reduced between the patient and control groups with short SOA （P 〈 0.05）. However, different patterns of interaction between task 2 and SOA were observed across subject groups： subjects with stuttering were more strongly modulated by SOA when the second task was semantic judgment or phonological judgment （P 〈 0.05）, but not in the orthographic judgment experiment （P 〉 0.05）. These results indicated that the interaction mechanism between semantic processing and phonological encoding might be an underlying cause for stuttering.展开更多
Physical-layer secret key generation(PSKG)provides a lightweight way for group key(GK)sharing between wireless users in large-scale wireless networks.However,most of the existing works in this field consider only grou...Physical-layer secret key generation(PSKG)provides a lightweight way for group key(GK)sharing between wireless users in large-scale wireless networks.However,most of the existing works in this field consider only group communication.For a commonly dual-task scenario,where both GK and pairwise key(PK)are required,traditional methods are less suitable for direct extension.For the first time,we discover a security issue with traditional methods in dual-task scenarios,which has not previously been recognized.We propose an innovative segment-based key generation method to solve this security issue.We do not directly use PK exclusively to negotiate the GK as traditional methods.Instead,we generate GK and PK separately through segmentation which is the first solution to meet dual-task.We also perform security and rate analysis.It is demonstrated that our method is effective in solving this security issue from an information-theoretic perspective.The rate results of simulation are also consistent with the our rate derivation.展开更多
Background: Mobility limitations and cognitive impairments which are common with ageing often coexist, causing a reduction in the levels of physical and mental activity and are prognostic of future adverse health even...Background: Mobility limitations and cognitive impairments which are common with ageing often coexist, causing a reduction in the levels of physical and mental activity and are prognostic of future adverse health events and falls. Consequently, multi-task training paradigms that simultaneously address both mobility and cognition benefit healthy ageing are important to consider in rehabilitation as well as primary prevention. Objectives: An exploratory RCT is being conducted to: a) describe the feasibility and acceptability of the study design and process, procedures, resources and management in two game-based dual-task training programs delivered in the community;b) to explore the lived experiences of the study participants who completed their respective exercise programs. A secondary objective is to obtain preliminary data on the therapeutic effectiveness of the two dual-task training programs. Methods: Thirty healthy older community dwelling participants aged 70 - 85 with previous history of falls will be recruited and randomized to either dual- task treadmill walking (experimental group) or dual-task recumbent bicycle (control group). Data analysis: The qualitative data will be analyzed by two investigators using a content analysis approach. For the quantitative data, outcome measures will be collected pre and post intervention and included measures to assess core balance, spatial-temporal gait variables, visual tracking and cognitive function, as well as, balance and gait analysis under dual-task conditions. Discussion: This research will demonstrate the feasibility of the dual-task training programs in the community, and demonstrate the system’s ability to improve targeted and integrated (dual-task) aspects of balance, mobility, gaze, and cognitive performance. A blended analysis of balance, mobility gaze and cognition will also contribute to a better understanding of the functional consequences of decline in physical and mental skills with age. Trial registration: This pilot clinical trial has been registered at ClinicalTrials.gov Protocol Registration System: NCT01940055.展开更多
Dual-task ability is crucial for daily life,but sensory,cognitive,and motor impairments often reduce performance in patients,significantly impacting their quality of life.To evaluate and restore this ability,this stud...Dual-task ability is crucial for daily life,but sensory,cognitive,and motor impairments often reduce performance in patients,significantly impacting their quality of life.To evaluate and restore this ability,this study proposes an eye-tracking-based dual-task training system for ankle movement and cognition.The system is designed to capture and analyze real-time ankle and eye movement parameters,integrating these with traditional clinical scales to offer a multidimensional,objective,and quantitative evaluation standard.Reliability and criterion validity analyses involving 20 healthy adults and 30 stroke patients demonstrated that 88.2%of the evaluation parameters exhibited high consistency,with 55.8%showing a moderate correlation with clinical benchmark scales(p<0.05).Notably,the Montreal Cognitive Assessment(MOCA),dual-task cost percentage,and TUG-subtraction task duration were identified as key indicators of dual-task ability,while the Self-Rating Anxiety Scale showed lower sensitivity.Furthermore,foot and ankle motion parameters exhibited a strong correlation with balance and fall risk,effectively serving as predictors of motor function recovery and fall risk in stroke patients.The system provides an innovative,quantitative tool for assessing lower limb dual-task ability,facili-tating the identification of dual-task performance differences among stroke patients.It supports the development of evidence-based rehabilitation strategies,with the potential to enhance long-term functional recovery and improve patients'quality of life.展开更多
Background and Aims:Liver stiffness(LS)measured by shear wave elastography(SWE)is often influenced by hepat-ic inflammation.The aim was to develop a dual-task convo-lutional neural network(DtCNN)model for the simultan...Background and Aims:Liver stiffness(LS)measured by shear wave elastography(SWE)is often influenced by hepat-ic inflammation.The aim was to develop a dual-task convo-lutional neural network(DtCNN)model for the simultaneous staging of liver fibrosis and inflammation activity using 2D-SWE.Methods:A total of 532 patients with chronic hepatitis B(CHB)were included to develop and validate the DtCNN model.An additional 180 consecutive patients between De-cember 2019 and April 2021 were prospectively included for further validation.All patients underwent 2D-SWE examina-tion and serum biomarker assessment.A DtCNN model con-taining two pathways for the staging of fibrosis and inflam-mation was used to improve the classification of significant fibrosis(≥F2),advanced fibrosis(≥F3)as well as cirrhosis(F4).Results:Both fibrosis and inflammation affected LS measurements by 2D-SWE.The proposed DtCNN performed the best among all the classification models for fibrosis stage[significant fibrosis AUC=0.89(95%CI:0.87-0.92),ad-vanced fibrosis AUC=0.87(95%CI:0.84-0.90),liver cirrho-sis AUC=0.85(95%CI:0.81-0.89)].The DtCNN-based pre-diction of inflammation activity achieved AUCs of 0.82(95%CI:0.78-0.86)for grade≥A1,0.88(95%CI:0.85-0.90)grade≥A2 and 0.78(95%CI:0.75-0.81)for grade≥A3,which were significantly higher than the AUCs of the single-task groups.Similar findings were observed in the prospec-tive study.Conclusions:The proposed DtCNN improved di-agnostic performance compared with existing fibrosis staging models by including inflammation in the model,which sup-ports its potential clinical application.展开更多
Background:This systematic review aimed to examine whether dual-task(DT)training was superior to single-task(ST)training in improving DT walking,balance and cognitive functions for individuals with Parkinson’s diseas...Background:This systematic review aimed to examine whether dual-task(DT)training was superior to single-task(ST)training in improving DT walking,balance and cognitive functions for individuals with Parkinson’s disease(PD).Methods:Literature search was performed in the following electronic databases:PubMed,the Cochrane Library,Web of Science,and Metstr covering inception to May 10,2023.And in order to facilitate comparison across trials,we calculated the effect size(Hedges’g)of gait,balance,cognitive,and other parameters under both ST and DT conditions,using the mean change score and standard deviation(SD)of change score of the experimental and control groups.Randomized controlled trials that examined the effects of DT motor and cognitive training in individuals with Parkinson’s disease were included for this systematic review.Results:A total of 214 participants recruited from six articles(actually five trials)were involved in this review.In terms of walking ability,only double support time and stride time variability showed significant between-group difference(Hedges’g=0.34,0.18,respectively).Compared to ST training group,DT training group had a more improvement effect in laboratory balance measurement(Hedges’g=0.18,1.25),but no significant improvement in clinical balance measurement.No significant between-group differences were observed,thus its training effect on cognitive function was inconclusive.Conclusions:The DT training failed to achieve promising results better than ST training in improving DT walking and balance functions for individuals with PD.Any firm conclusion cannot be drawn at present,due to the limited number of eligible publications.Larger sample size and high-quality studies are needed to investigate the effectiveness of DT training in individuals with PD.展开更多
In daily functional activities,the body needs the ability to perform two or more tasks at the same time(such as talking while walking).However,the gait disorder of patients with Parkinson's disease is aggravated w...In daily functional activities,the body needs the ability to perform two or more tasks at the same time(such as talking while walking).However,the gait disorder of patients with Parkinson's disease is aggravated when performing dual tasks,which seriously affects their quality of life.Therefore,the medical management plan should offer effective exercise training programming to improve Parkinson's disease patients'ability to perform dual tasks.Most traditional exercise intervention methods only focus on the perspective of exercise or cognition,ignoring their interaction,and fail to adequately resolve the dual task obstacles associated with Parkinson's disease.Some scholars put forward the concept of dual-task training and have applied dual-task training to pa-tients with neurological disorders and have achieved good therapeutic effects.Therefore,this article summarizes the research literature concerning dual-task training to improve cognitive impairment and walking function of Parkinson's disease patients,to evaluate and discuss possible mechanisms of action,and provide a basis for adjuvant treatment and rehabilitation of Parkinson's disease patients.展开更多
Objective:Although dual-task paradigm is commonly used in rehabilitation there is,currently,a lack of information about quantitative balance assessment performed in dual-task conditions.The aim of this study is to val...Objective:Although dual-task paradigm is commonly used in rehabilitation there is,currently,a lack of information about quantitative balance assessment performed in dual-task conditions.The aim of this study is to validate the use of the Nintendo Wii Balance Board(WBB)to assess balance modifications induced by dual-task activity in healthy subjects.Material and methods:Seventy-five healthy participants(37±14 years old,173±8 cm,7316 kg,35 women)participated in this study.Balance was recorded in control situation(baseline)and under two different cognitive tasks(verbal fluency and calculation).Each trial lasted for 60 s and were performed with eyes open and closed.Nine parameters were extracted based on center of pressure displacement based on a previously-validated method.ANOVA tests were used to compare the different conditions followed by Bonferroni’s corrections.Protocol was repeated one week after to assess the reproducibility.Results:Statistically significant differences were found comparing eyes open and closed situation.Concerning the influence of dual-tasks statistically significant decrease of the balance was observed for both eyes open and closed conditions(increase of the total sway and the speed of displacement).Concerning the reproducibility all parameters shows good to excellent ICC values for the different conditions.Conclusion:In this study,we demonstrated the validity of the WBB to detect the effect of the dual-task on balance in healthy subjects.Further studies are needed to determine if such a kind of evaluation can be used in clinics with subjects at risk of falling.展开更多
目的基于背侧注意网络(dorsal attention network,DAN)和默认网络(default network,DN)两个与注意力相关脑网络,探讨多焦点经颅直流电刺激(transcranial direct current stimulation,tDCS)能否改善健康老年人在双任务姿势控制中的表现...目的基于背侧注意网络(dorsal attention network,DAN)和默认网络(default network,DN)两个与注意力相关脑网络,探讨多焦点经颅直流电刺激(transcranial direct current stimulation,tDCS)能否改善健康老年人在双任务姿势控制中的表现。方法22名健康老年人被随机分配接受tDCS和假刺激,两次刺激间隔至少1周。tDCS方案旨在促进DAN的兴奋性并抑制DN的兴奋性,刺激时长为20 min(DAN+/DN-tDCS);假刺激方案仅持续1 min(刺激开始和结束各30 s)。在每次干预前后,使用测力台采集受试者在睁眼和闭眼条件下进行单、双任务姿势控制测试的压力中心数据。采用双因素重复测量(刺激方案×刺激前后)方差分析评估刺激方案对受试者各姿势控制指标的影响。结果所有受试者均完成实验,未出现明显不良反应。在睁眼双任务中,摆动合速度(F=5.72,P=0.021)和前后方向摆动速度(F=5.085,P=0.029)均存在显著交互作用。在DAN+/DN-tDCS干预后,前后方向摆动速度(P=0.019)和摆动合速度(P=0.01)均显著下降。睁眼条件下,摆动面积双任务消耗(F=8.727,P=0.005)也存在显著交互作用。在DAN+/DN-tDCS干预后摆动面积双任务消耗降低(P=0.038),而假刺激干预后摆动面积双任务消耗反而增加(P=0.049)。结论DAN+/DN-tDCS干预能显著改善健康老年人在双任务姿势控制中的表现(降低摆动速度、面积及双任务消耗),提示该刺激方案具有提升老年人在双任务条件下姿势控制稳定性的潜力。展开更多
文摘BACKGROUND Cognitive frailty and depression are prevalent among the elderly,significantly impairing physical and cognitive functions,psychological well-being,and quality of life.Effective interventions are essential to mitigate these adverse effects and enhance overall health outcomes in this population.AIM To evaluate the effects of exercise-cognitive dual-task training on frailty,cognitive function,psychological status,and quality of life in elderly patients with cognitive frailty and depression.METHODS A retrospective study was conducted on 130 patients with cognitive frailty and depression admitted between December 2021 and December 2023.Patients were divided into a control group receiving routine intervention and an observation group undergoing exercise-cognitive dual-task training in addition to routine care.Frailty,cognitive function,balance and gait,psychological status,and quality of life were assessed before and after the intervention.RESULTS After the intervention,the frailty score of the observation group was(5.32±0.69),lower than that of the control group(5.71±0.55).The Montreal cognitive assessment basic scale score in the observation group was(24.06±0.99),higher than the control group(23.43±1.40).The performance oriented mobility assessment score in the observation group was(21.81±1.24),higher than the control group(21.15±1.26).The self-efficacy in the observation group was(28.27±2.66),higher than the control group(30.05±2.66).The anxiety score in the hospital anxiety and depression scale(HADS)for the observation group was(5.86±0.68),lower than the control group(6.21±0.64).The depression score in the HADS for the observation group was(5.67±0.75),lower than the control group(6.27±0.92).Additionally,the scores for each dimension of the 36-item short form survey in the observation group were higher than those in the control group,with statistically significant differences(P<0.05).CONCLUSION Exercise-cognitive dual-task training is beneficial for improving frailty,enhancing cognitive function,and improving psychological status and quality of life in elderly patients with cognitive frailty and depression.
基金supported by the ScientificResearch and Innovation Team Program of Sichuan University of Science and Technology(No.SUSE652A006)Sichuan Key Provincial Research Base of Intelligent Tourism(ZHYJ22-03)In addition,it is also listed as a project of Sichuan Provincial Science and Technology Programme(2022YFG0028).
文摘Emotion recognition plays a crucial role in various fields and is a key task in natural language processing (NLP). The objective is to identify and interpret emotional expressions in text. However, traditional emotion recognition approaches often struggle in few-shot cross-domain scenarios due to their limited capacity to generalize semantic features across different domains. Additionally, these methods face challenges in accurately capturing complex emotional states, particularly those that are subtle or implicit. To overcome these limitations, we introduce a novel approach called Dual-Task Contrastive Meta-Learning (DTCML). This method combines meta-learning and contrastive learning to improve emotion recognition. Meta-learning enhances the model’s ability to generalize to new emotional tasks, while instance contrastive learning further refines the model by distinguishing unique features within each category, enabling it to better differentiate complex emotional expressions. Prototype contrastive learning, in turn, helps the model address the semantic complexity of emotions across different domains, enabling the model to learn fine-grained emotions expression. By leveraging dual tasks, DTCML learns from two domains simultaneously, the model is encouraged to learn more diverse and generalizable emotions features, thereby improving its cross-domain adaptability and robustness, and enhancing its generalization ability. We evaluated the performance of DTCML across four cross-domain settings, and the results show that our method outperforms the best baseline by 5.88%, 12.04%, 8.49%, and 8.40% in terms of accuracy.
基金Supported by Wuxi Taihu Talent Project,No.WXTTP 2021the General Scientific Research Program of Wuxi Municipal Health Commission,No.M202447.
文摘BACKGROUND Research has consistently demonstrated that patients with major depressive disorder(MDD)exhibit attentional switching dysfunction,and the dual-task paradigm has emerged as a valuable tool for probing cognitive deficits.However,the neuroelectrophysiological mechanism underlying this deficit has not been clarified.AIM To investigate the event-related potential(ERP)characteristics of attentional switching dysfunction and further explore the neuroelectrophysiological mechanism of the cognitive processing deficits underlying attentional switching dysfunction in MDD.METHODS The participants included 29 MDD patients and 29 healthy controls(HCs).The ERPs of the participants were measured while they performed the dual-task para digm.The behavioral and ERP N100,P200,P300,and late positive potential(LPP)data were analyzed.RESULTS This study revealed greater accuracy in HCs and slower reaction times(RTs)in MDD patients.Angry facial pictures led to lower accuracy.The results also revealed shorter RTs for happy facial pictures and the longest RTs for the 500-ms stimulus onset asynchrony.With respect to ERP characteristics,happy facial pictures and neutral facial pictures evoked higher amplitudes.The N100,P200,P300,and LPP amplitudes at Pz were the highest.MDD patients had lower P200 mean amplitudes and LPP amplitudes than HCs did.CONCLUSION In conclusion,MDD patients exhibited abnormal ERP characteristics evoked by the dual-task paradigm,which could be the neural correlates of the known abnormalities in attentional switching in patients with MDD.These results provide valuable insights into the understanding of the neural mechanisms of attentional switching function and may guide targeted interventions in patients with MDD.
基金supported by the National Natural Science Foundation of China(No.12305344)the 2023 Anhui university research project of China(No.2023AH052179).
文摘The off situ accurate reconstruction of the core neutron field is an important step in realizing real-time reactor monitoring.The existing off situ reconstruction method of the neutron field is only applicable to cases wherein a single region changes at a specified location of the core.However,when the neutron field changes are complex,the accurate identification of the individual changed regions becomes challenging,which seriously affects the accuracy and stability of the neutron field recon-struction.Therefore,this study proposed a dual-task hybrid network architecture(DTHNet)for off situ reconstruction of the core neutron field,which trained the outermost assembly reconstruction task and the core reconstruction task jointly such that the former could assist the latter in the reconstruction of the core neutron field under core complex changes.Furthermore,to exploit the characteristics of the ex-core detection signals,this study designed a global-local feature upsampling module that efficiently distributed the ex-core detection signals to each reconstruction unit to improve the accuracy and stability of reconstruction.Reconstruction experiments were performed on the simulation datasets of the CLEAR-I reactor to verify the accuracy and stability of the proposed method.The results showed that when the location uncertainty of a single region did not exceed nine and the number of multiple changed regions did not exceed five.Further,the reconstructed ARD was within 2%,RD_(max)was maintained within 17.5%,and the number of RD≥10%was maintained within 10.Furthermore,when the noise interference of the ex-core detection signals was within±2%,although the average number of RD≥10%increased to 16,the average ARD was still within in 2%,and the average RD_(max)was within 22%.Collectively,these results show that,theoretically,the DTHNet can accurately and stably reconstruct most of the neutron field under certain complex core changes.
文摘<strong>Objective</strong>: Purpose of this study was to investigate the behavioral and brain activity impairments in patients after moderate traumatic brain injury (mTBI) in comparison with the normal ranges while dual-tasks performing. We would like to evaluate dual-tasking as diagnostic and rehabilitation tool and to test hypothesis of brain aging after mTBI. <strong>Material and Methods</strong>: Electroencephalographic (EEG), stabilographic and clinical study was performed in 11 patients (mean age 28.8 ± 8.4 years) for up to 1 - 12 months after a mTBI in comparison with 17 healthy subjects (26.7 ± 5.1 years). All the participants performed two motor and two cognitive tasks presented separately, and simultaneously (dual-tasking). <strong>Results</strong>: Clinical examination revealed predominantly cognitive deficit in mTBI patients with intact postural control. EEG data demonstrated coherence decrease for slow (delta-theta) rhythms in frontal-temporal areas predominantly for left hemisphere during cognitive tasks performance. In contrast, EEG coherence for slow spectral bands increased in the same areas in healthy volunteers. EEG coherence increased for fast spectral bands—alpha2 and beta, predominantly in right hemisphere while both healthy adults and patients performed motor components of dual tasks. Rehabilitation course with dual tasks, led to a predominant reduction in cognitive deficits, and EEG coherence increases at the frontal-temporal areas of the left hemisphere. <strong>Conclusions</strong>: Dual-tasks may be used as diagnostic tool in patients after mTBI. This approach demonstrates predominant cognitive deficit, and left hemispheric dysfunction in patients similar to elderly persons and support the hypothesis of brain aging after TBI. Pilot studies also suggested rehabilitation effect of dual-tasking in mTBI patients.
基金the China Postdoctoral Science Foundation,No.2001,#14the Capital Medical Development Science Research Program,No.2005-2003
文摘Stuttering is a common neurological deficit and its underlying cognitive mechanisms are a matter of debate, with evidence suggesting abnormal modulation between speech encoding and other cognitive components. Previous studies have mainly used single task experiments to investigate the disturbance of language production. It is unclear whether there is abnormal interaction between the three language tasks （orthographic, phonological and semantic judgment） in stuttering patients. This study used dual tasks and manipulated the stimulus onset asynchrony （SOA） between tasks 1 and 2 and the nature of the second task, including orthographic, phonological, and semantic judgments. The results showed that the performance records of orthographic judgment, phonological judgment, and semantic judgment were significantly reduced between the patient and control groups with short SOA （P 〈 0.05）. However, different patterns of interaction between task 2 and SOA were observed across subject groups： subjects with stuttering were more strongly modulated by SOA when the second task was semantic judgment or phonological judgment （P 〈 0.05）, but not in the orthographic judgment experiment （P 〉 0.05）. These results indicated that the interaction mechanism between semantic processing and phonological encoding might be an underlying cause for stuttering.
基金supported in part by the National Key R&D Program of China(No.2022YFB2902202)in part by the Fundamental Research Funds for the Central Universities(No.2242023K30034)+2 种基金in part by the National Natural Science Foundation of China(No.62171121,U22A2001),in part by the National Natural Science Foundation of China(No.62301144)in part by the National Natural Science Foundation of Jiangsu Province,China(No.BK20211160)in part by the Southeast University Startup Fund(No.4009012301)。
文摘Physical-layer secret key generation(PSKG)provides a lightweight way for group key(GK)sharing between wireless users in large-scale wireless networks.However,most of the existing works in this field consider only group communication.For a commonly dual-task scenario,where both GK and pairwise key(PK)are required,traditional methods are less suitable for direct extension.For the first time,we discover a security issue with traditional methods in dual-task scenarios,which has not previously been recognized.We propose an innovative segment-based key generation method to solve this security issue.We do not directly use PK exclusively to negotiate the GK as traditional methods.Instead,we generate GK and PK separately through segmentation which is the first solution to meet dual-task.We also perform security and rate analysis.It is demonstrated that our method is effective in solving this security issue from an information-theoretic perspective.The rate results of simulation are also consistent with the our rate derivation.
文摘Background: Mobility limitations and cognitive impairments which are common with ageing often coexist, causing a reduction in the levels of physical and mental activity and are prognostic of future adverse health events and falls. Consequently, multi-task training paradigms that simultaneously address both mobility and cognition benefit healthy ageing are important to consider in rehabilitation as well as primary prevention. Objectives: An exploratory RCT is being conducted to: a) describe the feasibility and acceptability of the study design and process, procedures, resources and management in two game-based dual-task training programs delivered in the community;b) to explore the lived experiences of the study participants who completed their respective exercise programs. A secondary objective is to obtain preliminary data on the therapeutic effectiveness of the two dual-task training programs. Methods: Thirty healthy older community dwelling participants aged 70 - 85 with previous history of falls will be recruited and randomized to either dual- task treadmill walking (experimental group) or dual-task recumbent bicycle (control group). Data analysis: The qualitative data will be analyzed by two investigators using a content analysis approach. For the quantitative data, outcome measures will be collected pre and post intervention and included measures to assess core balance, spatial-temporal gait variables, visual tracking and cognitive function, as well as, balance and gait analysis under dual-task conditions. Discussion: This research will demonstrate the feasibility of the dual-task training programs in the community, and demonstrate the system’s ability to improve targeted and integrated (dual-task) aspects of balance, mobility, gaze, and cognitive performance. A blended analysis of balance, mobility gaze and cognition will also contribute to a better understanding of the functional consequences of decline in physical and mental skills with age. Trial registration: This pilot clinical trial has been registered at ClinicalTrials.gov Protocol Registration System: NCT01940055.
基金supported in part by Capital's Funds for Health Improvement and Research(2022-2Z-2242)in part by the National Natural Science Foundation of China under Grant 62171014.
文摘Dual-task ability is crucial for daily life,but sensory,cognitive,and motor impairments often reduce performance in patients,significantly impacting their quality of life.To evaluate and restore this ability,this study proposes an eye-tracking-based dual-task training system for ankle movement and cognition.The system is designed to capture and analyze real-time ankle and eye movement parameters,integrating these with traditional clinical scales to offer a multidimensional,objective,and quantitative evaluation standard.Reliability and criterion validity analyses involving 20 healthy adults and 30 stroke patients demonstrated that 88.2%of the evaluation parameters exhibited high consistency,with 55.8%showing a moderate correlation with clinical benchmark scales(p<0.05).Notably,the Montreal Cognitive Assessment(MOCA),dual-task cost percentage,and TUG-subtraction task duration were identified as key indicators of dual-task ability,while the Self-Rating Anxiety Scale showed lower sensitivity.Furthermore,foot and ankle motion parameters exhibited a strong correlation with balance and fall risk,effectively serving as predictors of motor function recovery and fall risk in stroke patients.The system provides an innovative,quantitative tool for assessing lower limb dual-task ability,facili-tating the identification of dual-task performance differences among stroke patients.It supports the development of evidence-based rehabilitation strategies,with the potential to enhance long-term functional recovery and improve patients'quality of life.
基金the National Natural Science Foundation of China(No.62001120)the Shanghai Sail-ing Program(No.20YF1402400).
文摘Background and Aims:Liver stiffness(LS)measured by shear wave elastography(SWE)is often influenced by hepat-ic inflammation.The aim was to develop a dual-task convo-lutional neural network(DtCNN)model for the simultaneous staging of liver fibrosis and inflammation activity using 2D-SWE.Methods:A total of 532 patients with chronic hepatitis B(CHB)were included to develop and validate the DtCNN model.An additional 180 consecutive patients between De-cember 2019 and April 2021 were prospectively included for further validation.All patients underwent 2D-SWE examina-tion and serum biomarker assessment.A DtCNN model con-taining two pathways for the staging of fibrosis and inflam-mation was used to improve the classification of significant fibrosis(≥F2),advanced fibrosis(≥F3)as well as cirrhosis(F4).Results:Both fibrosis and inflammation affected LS measurements by 2D-SWE.The proposed DtCNN performed the best among all the classification models for fibrosis stage[significant fibrosis AUC=0.89(95%CI:0.87-0.92),ad-vanced fibrosis AUC=0.87(95%CI:0.84-0.90),liver cirrho-sis AUC=0.85(95%CI:0.81-0.89)].The DtCNN-based pre-diction of inflammation activity achieved AUCs of 0.82(95%CI:0.78-0.86)for grade≥A1,0.88(95%CI:0.85-0.90)grade≥A2 and 0.78(95%CI:0.75-0.81)for grade≥A3,which were significantly higher than the AUCs of the single-task groups.Similar findings were observed in the prospec-tive study.Conclusions:The proposed DtCNN improved di-agnostic performance compared with existing fibrosis staging models by including inflammation in the model,which sup-ports its potential clinical application.
基金Kunming Health Science and Technology Talent Training Project,Training Plan for Medical Science and Technology Discipline Leaders(No.2022-SW[Leaders]-27)
文摘Background:This systematic review aimed to examine whether dual-task(DT)training was superior to single-task(ST)training in improving DT walking,balance and cognitive functions for individuals with Parkinson’s disease(PD).Methods:Literature search was performed in the following electronic databases:PubMed,the Cochrane Library,Web of Science,and Metstr covering inception to May 10,2023.And in order to facilitate comparison across trials,we calculated the effect size(Hedges’g)of gait,balance,cognitive,and other parameters under both ST and DT conditions,using the mean change score and standard deviation(SD)of change score of the experimental and control groups.Randomized controlled trials that examined the effects of DT motor and cognitive training in individuals with Parkinson’s disease were included for this systematic review.Results:A total of 214 participants recruited from six articles(actually five trials)were involved in this review.In terms of walking ability,only double support time and stride time variability showed significant between-group difference(Hedges’g=0.34,0.18,respectively).Compared to ST training group,DT training group had a more improvement effect in laboratory balance measurement(Hedges’g=0.18,1.25),but no significant improvement in clinical balance measurement.No significant between-group differences were observed,thus its training effect on cognitive function was inconclusive.Conclusions:The DT training failed to achieve promising results better than ST training in improving DT walking and balance functions for individuals with PD.Any firm conclusion cannot be drawn at present,due to the limited number of eligible publications.Larger sample size and high-quality studies are needed to investigate the effectiveness of DT training in individuals with PD.
基金supported by National key R&D projects(2019YFF0301805)the Science and Technology Innovation Project of Dalian,China(ZX20180690).
文摘In daily functional activities,the body needs the ability to perform two or more tasks at the same time(such as talking while walking).However,the gait disorder of patients with Parkinson's disease is aggravated when performing dual tasks,which seriously affects their quality of life.Therefore,the medical management plan should offer effective exercise training programming to improve Parkinson's disease patients'ability to perform dual tasks.Most traditional exercise intervention methods only focus on the perspective of exercise or cognition,ignoring their interaction,and fail to adequately resolve the dual task obstacles associated with Parkinson's disease.Some scholars put forward the concept of dual-task training and have applied dual-task training to pa-tients with neurological disorders and have achieved good therapeutic effects.Therefore,this article summarizes the research literature concerning dual-task training to improve cognitive impairment and walking function of Parkinson's disease patients,to evaluate and discuss possible mechanisms of action,and provide a basis for adjuvant treatment and rehabilitation of Parkinson's disease patients.
文摘Objective:Although dual-task paradigm is commonly used in rehabilitation there is,currently,a lack of information about quantitative balance assessment performed in dual-task conditions.The aim of this study is to validate the use of the Nintendo Wii Balance Board(WBB)to assess balance modifications induced by dual-task activity in healthy subjects.Material and methods:Seventy-five healthy participants(37±14 years old,173±8 cm,7316 kg,35 women)participated in this study.Balance was recorded in control situation(baseline)and under two different cognitive tasks(verbal fluency and calculation).Each trial lasted for 60 s and were performed with eyes open and closed.Nine parameters were extracted based on center of pressure displacement based on a previously-validated method.ANOVA tests were used to compare the different conditions followed by Bonferroni’s corrections.Protocol was repeated one week after to assess the reproducibility.Results:Statistically significant differences were found comparing eyes open and closed situation.Concerning the influence of dual-tasks statistically significant decrease of the balance was observed for both eyes open and closed conditions(increase of the total sway and the speed of displacement).Concerning the reproducibility all parameters shows good to excellent ICC values for the different conditions.Conclusion:In this study,we demonstrated the validity of the WBB to detect the effect of the dual-task on balance in healthy subjects.Further studies are needed to determine if such a kind of evaluation can be used in clinics with subjects at risk of falling.
文摘目的基于背侧注意网络(dorsal attention network,DAN)和默认网络(default network,DN)两个与注意力相关脑网络,探讨多焦点经颅直流电刺激(transcranial direct current stimulation,tDCS)能否改善健康老年人在双任务姿势控制中的表现。方法22名健康老年人被随机分配接受tDCS和假刺激,两次刺激间隔至少1周。tDCS方案旨在促进DAN的兴奋性并抑制DN的兴奋性,刺激时长为20 min(DAN+/DN-tDCS);假刺激方案仅持续1 min(刺激开始和结束各30 s)。在每次干预前后,使用测力台采集受试者在睁眼和闭眼条件下进行单、双任务姿势控制测试的压力中心数据。采用双因素重复测量(刺激方案×刺激前后)方差分析评估刺激方案对受试者各姿势控制指标的影响。结果所有受试者均完成实验,未出现明显不良反应。在睁眼双任务中,摆动合速度(F=5.72,P=0.021)和前后方向摆动速度(F=5.085,P=0.029)均存在显著交互作用。在DAN+/DN-tDCS干预后,前后方向摆动速度(P=0.019)和摆动合速度(P=0.01)均显著下降。睁眼条件下,摆动面积双任务消耗(F=8.727,P=0.005)也存在显著交互作用。在DAN+/DN-tDCS干预后摆动面积双任务消耗降低(P=0.038),而假刺激干预后摆动面积双任务消耗反而增加(P=0.049)。结论DAN+/DN-tDCS干预能显著改善健康老年人在双任务姿势控制中的表现(降低摆动速度、面积及双任务消耗),提示该刺激方案具有提升老年人在双任务条件下姿势控制稳定性的潜力。
