A survey involving 6103 participants from five Chinese provinces was conducted to evaluate the threshold value of urinary cadmium （UCd） for renal dysfunction as benchmark dose low （BMDL）. The urinary N-acetyl-13-D...A survey involving 6103 participants from five Chinese provinces was conducted to evaluate the threshold value of urinary cadmium （UCd） for renal dysfunction as benchmark dose low （BMDL）. The urinary N-acetyl-13-D-glucosaminidase （UNAG） was chosen as an effect biomarker. The UCd BMDLs for UNAG ranged from 2.18μg/g creatinine （cr） to 4.26μg/g cr in the populations of different provinces. The selection of the sample population and area affect the evaluation of the BMDL. The reference level of UCd for renal effects was further evaluated based on the data of all 6103 subjects. With benchmark responses （BMR） of 10%/5%, the overall UCd BMDLs for males in the total population were 3.73/2.08 μg/g cr. The BMD was slightly lower in females, thereby indicating that females may be relatively more sensitive to Cd exposure than are males.展开更多
Objective To develop an individual noise exposure dose estimation model based on spatial distribution of noise in order to provide reference for occupational health management and hearing loss risk assessment caused b...Objective To develop an individual noise exposure dose estimation model based on spatial distribution of noise in order to provide reference for occupational health management and hearing loss risk assessment caused by noise in workplace.Methods From July 2018 to October 2019,10 noise-exposed positions and 48 employees in 3 high-noise workplaces of a manufacturing enterprise in Sichuan Province were selected as the research subjects.Occupational health survey,fixed-point measurement of workplace noise and individual noise measurement were used to obtain noise intensity and employee exposure information.The mean noise intensity and the corresponding exposure time were weighed to estimate the individual noise exposure dose estimation model based on the spatial distribution of workplace noise,and the paired t-test was used to evaluate the accuracy of the individual noise exposure dose estimate(8 h equivalent sound level,Lex,8 h)based on the spatial distribution of workplace,noise and the measured value of individualnoise exposure dose.And the least square regression model was used to correct it.Results The daily noise exposure dose of 44(91.7%)of 48 workers in 10 types of work in 3 sites of the manufacturing enterprise exceeded the standard,and the maximum noise exposure intensity was up to 108.3 dB(A).The measured value of individual noise exposure dose was higher than Lex,s h,and the difference was statistically significant(P<0.001).The noise difference distribution was mostly positive and symmetrical(P=0.958).The measured noise exposure dose of 6 out of 10 work types in 3 sites was higher than Lex,8 h(all P<0.05),and there was a linear correlation between the measured dose and Lex.8 h(r=0.373,P<0.05).Considering the influence of systematic error and the construction,diagnosis and screening of adaptive assessment model,an individual noise exposure dose estimation model based on the spatial distribution of workplace noise was finally obtained:y=0.574x+45.250,where y was the measured value of individual noise exposure dose,x was Lex,s h value.Conclusion The high noise hazard in manufacturing industry is more serious,and the noise exposure assessment of single fixed-point detection is relatively rough.The individual noise exposure dose estimation model based on the spatial distribution of workplace noise has a certain role in the occupational health managementofworkplacenoise hazard in manufacturing industry.展开更多
With the rapid development of computed tomography(CT)technology,the widespread use of CT examinations in the evaluation of chest diseases in pediatrics has raised extensive concerns about radiation issues.This review ...With the rapid development of computed tomography(CT)technology,the widespread use of CT examinations in the evaluation of chest diseases in pediatrics has raised extensive concerns about radiation issues.This review first systematically summarizes the factors influencing radiation dose(detector,tube voltage,tube current-time product,field of view,and reconstruction algorithms)in pediatric chest computed tomography examinations.Methods to reduce radia-tion dose are also discussed,including the utilization of filters,automatic tube current modulation,automatic tube voltage selection,and organ dose modulation.Finally,the methods for individualized radiation dose calculation in pediatric chest CT examinations:effective dose,CT dosimetry software,Size-Specific Dose Estimate,and the Monte Carlo method are reviewed.Radiation exposure re-duction is a multifaceted issue.This review aims to provide an optimal scanning scheme for pediatric chest CT from different perspectives.展开更多
Objective To obtain precise data on the changes in the levels of 29 cytokines in mice after high or low linear energy transfer(LET)irradiation and to develop an accurate model of radiation exposure based on the cytoki...Objective To obtain precise data on the changes in the levels of 29 cytokines in mice after high or low linear energy transfer(LET)irradiation and to develop an accurate model of radiation exposure based on the cytokine levels after irradiation.Methods Plasma samples harvested from mice at different time points after carbon-ion or X-ray irradiation were analyzed using meso-scale discovery(MSD),a high-throughput and sensitive electrochemiluminescence measurement technique.Dose estimation equations were set up using multiple linear regression analysis.Results The relative levels of IL-6 at 1 h,IL-5 and IL-6 at 24 h,and IL-5,IL-6 and IL-15 at 7 d after irradiation with two intensities increased dose-dependently.The minimum measured levels of IL-5,IL-6 and IL-15 were up to 4.0076 pg/mL,16.4538 pg/mL and 0.4150 pg/mL,respectively.In addition,dose estimation models were established and verified.Conclusions The MSD assay can provide more accurate data regarding the changes in the levels of the cytokines IL-5,IL-6 and IL-15.These cytokines could meet the essential criteria for radiosensitive biomarkers and can be used as radiation indicators.Our prediction models can conveniently and accurately estimate the exposure dose in irradiated organism.展开更多
This study designed to evaluate the entrance surface air kerma (ESAK) to the patient during X-ray examination to the skull antero-posterior (AP), skull Lateral (LAT), chest postero-anterior (PA), Lumber spine AP/LAT a...This study designed to evaluate the entrance surface air kerma (ESAK) to the patient during X-ray examination to the skull antero-posterior (AP), skull Lateral (LAT), chest postero-anterior (PA), Lumber spine AP/LAT and Pelvis AP. Totally, 408 patients were included in this study using computed radiography (CR) in different three hospitals in Khartoum;five X-ray machines were covered. The entrance surface air kerma (ESAK) was calculated for each patient from the exposure parameters using different peak tube voltages. Patient’s data such as (age and weight) and exposure parameters (kVp) and (mAs) were recorded. The result obtained showed that, the entrance surface air kerma ranged from 0.88 to 3.30 mGy for Skull (AP), 0.588 to 1.87 mGy for skull (LAT), 0.03 to 2 mGy for chest PA, 1.50 to 3.40 mGy Lumbar spine AP, 2.60 to 5.15 mGy for Lumbar spine (LAT), and 1.05 to 4.40 mGy for Pelvis. This study provides additional data that can help the regulatory authority to establish reference dose level for diagnostic radiology in Sudan. This study recommends that the CR operator must be used to optimize the patient dose by using the best strategies available for reducing radiation dose. Computed radiography must be used with high level training for medical staff to reduce the dose;each radiology department should implement a patient dose measurement quality assurance programme. Doses to the patients should be regularly monitored and the proposed national DRLs should be taken as guidance for optimization.展开更多
基金financially supported by Special Funds of the State Environmental Protection Public Welfare Industry(201009049201309049)+1 种基金National Key Technology Research and Development Program of the Ministry of Science and Technology of China(2013BAI12B03)the Fundamental Research Funds for the Central Universities(2015JBM108)
文摘A survey involving 6103 participants from five Chinese provinces was conducted to evaluate the threshold value of urinary cadmium （UCd） for renal dysfunction as benchmark dose low （BMDL）. The urinary N-acetyl-13-D-glucosaminidase （UNAG） was chosen as an effect biomarker. The UCd BMDLs for UNAG ranged from 2.18μg/g creatinine （cr） to 4.26μg/g cr in the populations of different provinces. The selection of the sample population and area affect the evaluation of the BMDL. The reference level of UCd for renal effects was further evaluated based on the data of all 6103 subjects. With benchmark responses （BMR） of 10%/5%, the overall UCd BMDLs for males in the total population were 3.73/2.08 μg/g cr. The BMD was slightly lower in females, thereby indicating that females may be relatively more sensitive to Cd exposure than are males.
文摘Objective To develop an individual noise exposure dose estimation model based on spatial distribution of noise in order to provide reference for occupational health management and hearing loss risk assessment caused by noise in workplace.Methods From July 2018 to October 2019,10 noise-exposed positions and 48 employees in 3 high-noise workplaces of a manufacturing enterprise in Sichuan Province were selected as the research subjects.Occupational health survey,fixed-point measurement of workplace noise and individual noise measurement were used to obtain noise intensity and employee exposure information.The mean noise intensity and the corresponding exposure time were weighed to estimate the individual noise exposure dose estimation model based on the spatial distribution of workplace noise,and the paired t-test was used to evaluate the accuracy of the individual noise exposure dose estimate(8 h equivalent sound level,Lex,8 h)based on the spatial distribution of workplace,noise and the measured value of individualnoise exposure dose.And the least square regression model was used to correct it.Results The daily noise exposure dose of 44(91.7%)of 48 workers in 10 types of work in 3 sites of the manufacturing enterprise exceeded the standard,and the maximum noise exposure intensity was up to 108.3 dB(A).The measured value of individual noise exposure dose was higher than Lex,s h,and the difference was statistically significant(P<0.001).The noise difference distribution was mostly positive and symmetrical(P=0.958).The measured noise exposure dose of 6 out of 10 work types in 3 sites was higher than Lex,8 h(all P<0.05),and there was a linear correlation between the measured dose and Lex.8 h(r=0.373,P<0.05).Considering the influence of systematic error and the construction,diagnosis and screening of adaptive assessment model,an individual noise exposure dose estimation model based on the spatial distribution of workplace noise was finally obtained:y=0.574x+45.250,where y was the measured value of individual noise exposure dose,x was Lex,s h value.Conclusion The high noise hazard in manufacturing industry is more serious,and the noise exposure assessment of single fixed-point detection is relatively rough.The individual noise exposure dose estimation model based on the spatial distribution of workplace noise has a certain role in the occupational health managementofworkplacenoise hazard in manufacturing industry.
基金Supported by the Key Natural Science Project of the Anhui Provincial Education Department Under,No.KJ2021A0746.
文摘With the rapid development of computed tomography(CT)technology,the widespread use of CT examinations in the evaluation of chest diseases in pediatrics has raised extensive concerns about radiation issues.This review first systematically summarizes the factors influencing radiation dose(detector,tube voltage,tube current-time product,field of view,and reconstruction algorithms)in pediatric chest computed tomography examinations.Methods to reduce radia-tion dose are also discussed,including the utilization of filters,automatic tube current modulation,automatic tube voltage selection,and organ dose modulation.Finally,the methods for individualized radiation dose calculation in pediatric chest CT examinations:effective dose,CT dosimetry software,Size-Specific Dose Estimate,and the Monte Carlo method are reviewed.Radiation exposure re-duction is a multifaceted issue.This review aims to provide an optimal scanning scheme for pediatric chest CT from different perspectives.
基金supported by the National Natural Science Foundation of China[11635013,11705248,U1832101]National Key Research and Development Program of China[2017YFC0108605]the Science and Technology Research Project of Gansu Province[No.145RTSA012 and 17JR5RA307]。
文摘Objective To obtain precise data on the changes in the levels of 29 cytokines in mice after high or low linear energy transfer(LET)irradiation and to develop an accurate model of radiation exposure based on the cytokine levels after irradiation.Methods Plasma samples harvested from mice at different time points after carbon-ion or X-ray irradiation were analyzed using meso-scale discovery(MSD),a high-throughput and sensitive electrochemiluminescence measurement technique.Dose estimation equations were set up using multiple linear regression analysis.Results The relative levels of IL-6 at 1 h,IL-5 and IL-6 at 24 h,and IL-5,IL-6 and IL-15 at 7 d after irradiation with two intensities increased dose-dependently.The minimum measured levels of IL-5,IL-6 and IL-15 were up to 4.0076 pg/mL,16.4538 pg/mL and 0.4150 pg/mL,respectively.In addition,dose estimation models were established and verified.Conclusions The MSD assay can provide more accurate data regarding the changes in the levels of the cytokines IL-5,IL-6 and IL-15.These cytokines could meet the essential criteria for radiosensitive biomarkers and can be used as radiation indicators.Our prediction models can conveniently and accurately estimate the exposure dose in irradiated organism.
文摘This study designed to evaluate the entrance surface air kerma (ESAK) to the patient during X-ray examination to the skull antero-posterior (AP), skull Lateral (LAT), chest postero-anterior (PA), Lumber spine AP/LAT and Pelvis AP. Totally, 408 patients were included in this study using computed radiography (CR) in different three hospitals in Khartoum;five X-ray machines were covered. The entrance surface air kerma (ESAK) was calculated for each patient from the exposure parameters using different peak tube voltages. Patient’s data such as (age and weight) and exposure parameters (kVp) and (mAs) were recorded. The result obtained showed that, the entrance surface air kerma ranged from 0.88 to 3.30 mGy for Skull (AP), 0.588 to 1.87 mGy for skull (LAT), 0.03 to 2 mGy for chest PA, 1.50 to 3.40 mGy Lumbar spine AP, 2.60 to 5.15 mGy for Lumbar spine (LAT), and 1.05 to 4.40 mGy for Pelvis. This study provides additional data that can help the regulatory authority to establish reference dose level for diagnostic radiology in Sudan. This study recommends that the CR operator must be used to optimize the patient dose by using the best strategies available for reducing radiation dose. Computed radiography must be used with high level training for medical staff to reduce the dose;each radiology department should implement a patient dose measurement quality assurance programme. Doses to the patients should be regularly monitored and the proposed national DRLs should be taken as guidance for optimization.
