Prostate-specific membrane antigen (PSMA) is a cellsurface glycoprotein expressed predominantly in prostatesecretory acinar epithelium and prostate cancer cells aswell as in several extraprostatic tissues. Mouse monoc...Prostate-specific membrane antigen (PSMA) is a cellsurface glycoprotein expressed predominantly in prostatesecretory acinar epithelium and prostate cancer cells aswell as in several extraprostatic tissues. Mouse monoclonal antibody 4G5 specific to the extracellular domainof PSMA was used to screen two phage displayed peptide libraries (9aa linear and 9aa cys library). Three 4G5reactive phagotopes were identified. Sequence analysis ofisolated clones demonstrated that the interaction motif'VDPA/SK' has high homology to 719-725aa on PSMA.Immunohistochemical staming of the prostate cancer sam ple with the PSMA-mimic phagotope (mimotope) immunized serum antibodies demonstrate that the mimotopeisolated from the phage displayed peptide libraries can induce PSMA specific immune response in vivo.展开更多
BERNARDO Bertolucci’s film, The Last Emperor, drew its Western audience into a mystic, grandiose, oriental palace that was the Forbidden City, leaving them awestruck at the
The primers were designed according to the gene sequence of lipocalin protein family,and the gene sequence containing random mutation protein was obtained by overlapping extension of PCR.The random mutation lipocalin ...The primers were designed according to the gene sequence of lipocalin protein family,and the gene sequence containing random mutation protein was obtained by overlapping extension of PCR.The random mutation lipocalin library was constructed using phagemid expression vector.Lipocalin library was screened by subtracted screening of NSF60 cells and affinity screening of mast cells,and the lipocalin secondary library binding to mast cells was obtained.Then the lipocalin secondary library was enriched and screened with FcεRI-αreceptor protein as target molecule,and specific binding phages were eluted.After three rounds of screening,eight recombinant phage clones were randomly selected from elution clones of the third round.ELISA assay showed that three anticalin molecules could specifically bind to the FcεRI-αreceptor of mast cells.These results may provide some candidate biological molecules for the development of blocking drugs of mast cell FcεRI-αreceptor,and also lay the foundation for the development of biological small molecule drugs to treat Ig E associated allergic diseases.展开更多
A library of 2 ×107 random octapeptides was constructed by use of phagemid-based monovalent phage display system. The randomly synthesized degenerated oligodeoxyribonucleotides (oligos ) were fused to the truncat...A library of 2 ×107 random octapeptides was constructed by use of phagemid-based monovalent phage display system. The randomly synthesized degenerated oligodeoxyribonucleotides (oligos ) were fused to the truncated g Ⅲ (p230-p403). Sequence analysis of 11 randomly chosen clones suggested that the degenerated inserts and its deduced amino acid (aa) sequences are randomly distributed. The library was used to select binding peptides to the monoclonal antibody (mAb) 9E10, which recognizes a continuous decapeptide epi- tope of denatured human c-myc protein. After four to five rounds of panning, most of the eluted clones could bind to 9E10. Sequence analysis of the selected positive clones indicated that the binding sequences could fall into two classes, one class (clone 1) shares a consensus motif, ISE x x L, with c-myc decapeptide; and the sequences of the other class are entirely different. The binding of both classes to 9E10 could be specifically inhibited by free c-myc decapeptide. The immunogenicity of the phage peptide was further investigated by construction of multivalent displayed phage peptides and immunization of animals with or without adjuvant. ELISA and competitive ELISA showed that anti-serum from both mice and rabbit immunized with either clone could bind to the original antigen, c-myc decapeptide. These results denote that in spite of the dissimilarity of the selected peptides with c-myc decapeptide, they are capable of inducing similar immune respones in vivo, thus actually mimicking the antigen epitope.展开更多
Haloxyfop-P-methyl,a widely used aryloxyphenoxypropionate herbicide,has been identified as a potential hazard to ecological security and human health.Consequently,it is essential to develop superior methods for detect...Haloxyfop-P-methyl,a widely used aryloxyphenoxypropionate herbicide,has been identified as a potential hazard to ecological security and human health.Consequently,it is essential to develop superior methods for detecting haloxyfop-P-methyl.In this study,12 peptidomimetics and 4 anti-immunocomplex peptides were isolated from phage-displayed peptide libraries,which can specifically recognize the anti-haloxyfop-P-methyl antibody and the immunocomplex formed by haloxyfop-P-methyl and its antibody,respectively.Following the sensitivity assessment of each phage-displayed peptide,competitive and noncompetitive phage enzyme-linked immunosorbent assays(P-ELISAs)were developed using the best phage-displayed peptides.The half inhibition concentration(IC50)and half saturation concentration(SC50)of competitive and noncompetitive P-ELISAs were determined to be 8.15 and 1.83 ng/mL,respectively,representing the 5-fold and 22-fold increase in sensitivity compared to previously reported immunoassay.The competitive P-ELISA exhibited 2.2%-114.8% crossreactivities(CRs)to haloxyfop-methyl,haloxyfop and quizalofop-p-ethyl,while the noncompetitive P-ELISA showed no significant CR(<0.1%)except for haloxyfop-methyl(CR=41.6%).The average recoveries of two PELISAs in soil,soybean,potato,and cabbage samples ranged from 78.4% to 104.3% and 76.8%-95.2%,respectively.Additionally,the results of P-ELISAs for blind samples exhibited a good correlation with those obtained from ultra-performance liquid chromatography/tandem mass spectrometry.展开更多
Neutralizing antibodies are essential tools in antiviral therapy and epidemic preparedness,capable of directlyinhibiting viral entry and limiting disease progression.However,traditional antibody discovery strategies—...Neutralizing antibodies are essential tools in antiviral therapy and epidemic preparedness,capable of directlyinhibiting viral entry and limiting disease progression.However,traditional antibody discovery strategies—suchas animal immunization or B cell isolation from infected individuals—are often hindered by biosafety concerns,lengthy development timelines,and limited adaptability during outbreaks.In the present study,we aimed toestablish a robust and rapid in vitro platform for the efficient isolation of neutralizing antibodies targetingconserved viral epitopes.We developed an epitope-guided negative screening strategy that integrates phagedisplay technology with rational antigen mutagenesis to exclude antibodies against variable regions whileenriching for those that recognize functionally constrained epitopes.When applied to the receptor-binding domainof severe acute respiratory syndrome coronavirus 2,this method enabled the identification of six neutralizingantibodies(one IgG and five nanobodies)exhibiting broad-spectrum neutralizing activity across multiple viralvariants.Notably,antibodies recognizing distinct epitopes demonstrated significant synergistic neutralizationwhen used in combination(P<0.05).This screening approach facilitates the rapid discovery of potent andmutation-resistant antibodies and holds promise for application to other emerging pathogens.Our findingsunderscore the potential of epitope-guided,in vitro platforms in expediting therapeutic antibody developmentunder conditions of high biosafety requirements.展开更多
In an era dominated by visual information,the display interface serves as a critical gateway between the human and digital worlds.The relentless pursuit of visual immersion has driven display technology from cinema sc...In an era dominated by visual information,the display interface serves as a critical gateway between the human and digital worlds.The relentless pursuit of visual immersion has driven display technology from cinema screens to smart-phones and now to virtual and augmented reality(VR/AR)headsets,progressively moving closer to the human eye.This evolution places unprecedented demands on pixel density,power efficiency,and form factor,pushing up against funda-mental physical and physiological limits.展开更多
As the sunlight scattered on the sea of Guanyinshan in Xiamen,a space that bridges creativity and industry opened its door to the world.On December 15th,following a ribbon-cutting and unveiling ceremony,YKK Xiamen Gua...As the sunlight scattered on the sea of Guanyinshan in Xiamen,a space that bridges creativity and industry opened its door to the world.On December 15th,following a ribbon-cutting and unveiling ceremony,YKK Xiamen Guanyinshan Showroom,the brand's second and largest comprehensive showroom,was officially inaugurated.This showroom is more than a product display window,it is an"Inspiration Hub"integrating exhibition,co-creation,and service.Its launch signifies YKK's progression in the Chinese market from“building an efficient product proposal system”to a new stage of“deep collaborative co-creation.”展开更多
Detector and event visualization are crucial components of high-energy physics(HEP)experimental software.Virtual reality(VR)technologies and multimedia development platforms,such as Unity,offer enhanced display effect...Detector and event visualization are crucial components of high-energy physics(HEP)experimental software.Virtual reality(VR)technologies and multimedia development platforms,such as Unity,offer enhanced display effects and flexible extensibility for visualization in HEP experiments.In this study,we present a VR-based method for detector and event displays in the Jiangmen Underground Neutrino Observatory(JUNO)experiment.This method shares the same detector geometry descriptions and event data model as those in the offline software and provides the necessary data conversion interfaces.The VR methodology facilitates an immersive exploration of the virtual environment in JUNO,enabling users to investigate the detector geometry,visualize event data,and tune the detector simulation and event reconstruction algorithms.Additionally,this approach supports applications in data monitoring,physics data analysis,and public outreach initiatives.展开更多
The advent of artificial intelligence(AI)has propelled augmented reality(AR)display technology to a pivotal juncture,positioning it as a contender for the next generation of mobile intelligent terminals.However,the pu...The advent of artificial intelligence(AI)has propelled augmented reality(AR)display technology to a pivotal juncture,positioning it as a contender for the next generation of mobile intelligent terminals.However,the pursuit of advanced AR displays,particularly those capable of delivering immersive 3D experiences,is significantly hindered by the performance limitations of current hardware and the complexity of system integration.In this study,we present an innovative multi-focal plane AR display system that integrates a non-orthogonal polarization-multiplexing metasurface,freeform optical elements,and an OLED display screen.All optical elements are integrated into a single solid-state architecture,based on a joint optimization design approach of ray tracing and diffraction theory.The multi-focal plane AR visual effect is realized by the compact and multiplexing metasurface,which performs distinct phase functions across diverse polarization channels.Meanwhile,freeform surfaces offer ample design flexibility for the collaborative optimization of multi-focal plane imaging and the see-through systems.Followed by a mechanical design and prototype assembly,we demonstrate the system's capabilities in real-time and multi-focal plane display.The digital images at all virtual image distances seamlessly integrate with the real environment,fully exhibiting the system's high parallelism and real-time interactivity.With the innovative design concept and joint design method,we believe that our work will spur more innovative and compact intelligent solutions for AR displays and inject new vitality into hybrid optical systems.展开更多
Head-up displays(HUDs)are emerging as key components of intelligent vehicles,requiring wide-depth,large-area,and high-efficiency dynamic imaging,which remains difficult to realize with traditional refractive optics.Co...Head-up displays(HUDs)are emerging as key components of intelligent vehicles,requiring wide-depth,large-area,and high-efficiency dynamic imaging,which remains difficult to realize with traditional refractive optics.Computer-generated holography(CGH)with diffraction optics offers a promising solution to these technical demands.However,CGH optimization based on the fast Fourier transform(FFT)faces limitations such as zero-padding redundancy,coupled sampling intervals,and incompatible near-and farfield propagation models.Here,we report a holography-based multiplane HUD using a matrix multiplication(MM)-assisted diffraction algorithm that restructures the Fresnel integral into two sequential matrix operations,thus eliminating zero-padding and enabling fully decoupled sampling between object and image planes.Compared with FFT-based angular spectrum methods,the MM approach significantly improves computational speed and memory efficiency for hologram design,which is validated by demonstrating dual-plane holography with a size ratio exceeding 100:1 and unified reconstruction across Fresnel and Fraunhofer regimes within a single computation.A prototype HUD system is demonstrated successfully to exhibit multiple-plane holographic virtual images that can be mixed with real-world objects at three independent planes.The technique might be one of the potential candidates for next-generation intelligent vehicle displays.展开更多
Unlike conventional electrochromic devices,Zinc anode-based electrochromic devices(ZECDs)ensure excellent charge balance between the electrochromic layer and Zn anode during the coloring/bleaching by reversible metal ...Unlike conventional electrochromic devices,Zinc anode-based electrochromic devices(ZECDs)ensure excellent charge balance between the electrochromic layer and Zn anode during the coloring/bleaching by reversible metal deposition/stripping on the Zn anode.Meanwhile,the inherent potential difference between the metal anode and the electrochromic layer can drive the spontaneous coloration/bleaching of ZECDs,featuring energy retrieval functionality.This review discusses the working mechanisms,performance indexes of ZECDs,and the impact of material selection on ZECD performance.Furthermore,we comprehensively summarize the latest research progress of ZECDs in energy storage,smart windows,and multicolor displays.We argue that using high-transparency zinc mesh,additive manufacturing processes,and self-healing electrochromic materials can significantly advance the commercialization of large-area ZECDs.Finally,“electrode-free”device structures,renewable or replaceable electrolytes,and strategies to suppress zinc dendrites are prospected to overcome cost-effectiveness and lifespan issues of ZECDs.This review aims at enabling more efficient and advanced ZECDs for multifunctional applications.展开更多
To address the challenges of complexity,power consumption,and cost constraints in traditional display driver integrated circuits(DDICs)caused by external NOR Flash and SRAM,this work proposes an embedded resistive ran...To address the challenges of complexity,power consumption,and cost constraints in traditional display driver integrated circuits(DDICs)caused by external NOR Flash and SRAM,this work proposes an embedded resistive random-access memory(RRAM)integration solution based on a 40 nm high-voltage CMOS logic platform.Targeting the yield fluctuations and stability challenges during RRAM mass production,systematic process optimizations are implemented to achieve synergistic improvements in RRAM performance and yield.Through modifications to the film sputtering and pre-deposition treatment,the withinwafer resistance uniformity(RSU)of the oxygen-deficient layer(ODL)thin film is improved from 11%to 8%,while inter-wafer process stability variation reduces from 23%to below 6%.Consequently,the yield of 8 Mb RRAM embedded mass production products increases from 87%to 98.5%.In terms of device performance,the RRAM demonstrates a fast 4.8 ns read speed,exceptional read disturb immunity of 3×10^(8) cycles at 95℃,10^(3) write/erase endurance cycles for the 1 Mb cells,and data retention of 12.5 years at 125℃.Post high-temperature operating life(HTOL)testing exhibits stable high/low resistance window.This study provides process optimization strategies and a reliability assurance framework for the mass production of highly integrated,low-power embedded RRAM display driver IC.展开更多
White Cyphochilus insulanus beetles,exhibiting both environmental camouflage display and radiative cooling functions,serve as a good prototype for biomimetic fabrication.As inspired,this work presents a femtosecond(fs...White Cyphochilus insulanus beetles,exhibiting both environmental camouflage display and radiative cooling functions,serve as a good prototype for biomimetic fabrication.As inspired,this work presents a femtosecond(fs)laser-based biomimetic fabrication strategy that takes full use of the synthesized radiative cooling nanomaterials for a groundbreaking stimuli-responsive infrared(IR)impressionistic camouflage display.The proposed technique is capable of readily transforming various substrates(quartz glass and metals including Ti,Al,Zr,and W)into self-assembled porous networks(aerogels)consisting of oxygen-vacancy-rich oxide nanoparticles.Surprisingly,the emissions of all as-prepared porous particle-networks in the radiative-cooling long-wavelength infrared(LWIR)band are above 95%,with the SiO_(2) aerogels reaching a maximum of 99.6%.Benefiting from the far-from-equilibrium thermodynamic kinetics,metastable phases of anatase TiO_(2),tetragonal zirconia(t-ZrO_(2)),and monoclinic WO_(3)(Pc)are synthesizable,opening up opportunities for exploring their optical applications.Taking the low-temperature metastable phase WO_(3)(Pc)as representative for systematic studies,it is found that(1)the ratio WO_(3)(Pc)phase to that of room-temperature phase of WO_(3)(P2_(1)/n)can be tailored by modulation of processing parameters;(2)laser synthesized aerogels with hybrid phases of WO_(3)(Pc)and WO_(3)(P2_(1)/n)have a brighter visible whiteness,higher visible/nearinfrared(NIR)spectral selectivity than the natural prototype of white Cyphochilus insulanus beetles but with comparable LWIR emittance.White WO_(3) aerogel in situ deposited during flexibly fs laser artistic patterning can blur the painting features due to its radiative cooling effect,allowing a colorful impressionistic IR display in the heating mode.What's more,invisible painting features concealed by the white deposited WO_(3) aerogel are clearly/faintly distinguishable by introducing external stimuli of a human hand and sample heating,respectively,catalyzing progress in optical encryption and selectively stimuli-responsive decryption display in the infrared band.展开更多
China’s 30 plus provinces,municipalities and autonomous regions take turns showcasing their culture and customs at the ongoing World Expo in Shanghai. Beijing took the lead by hosting Beijing Week in May. Since then,...China’s 30 plus provinces,municipalities and autonomous regions take turns showcasing their culture and customs at the ongoing World Expo in Shanghai. Beijing took the lead by hosting Beijing Week in May. Since then,many local arts have been featured,such as the New Year paintings of Tianjin’ s Yangliuqing Town,the pastoral songs of the Inner Mongolia Autonomous Region,the song-and-dance duet popular in northeast China and the acrobatics of Hebei’ s Wuqiao County.展开更多
Ford Motor,for the first time,displayed its globalproducts at the 8th Beijing Intemational Motor Show on June8 with its new generation Focus concept car making a globaldebut. The exhibits included the vehicles designe...Ford Motor,for the first time,displayed its globalproducts at the 8th Beijing Intemational Motor Show on June8 with its new generation Focus concept car making a globaldebut. The exhibits included the vehicles designed andmanufactured in North America,Europe and Australia.Ford,展开更多
文摘Prostate-specific membrane antigen (PSMA) is a cellsurface glycoprotein expressed predominantly in prostatesecretory acinar epithelium and prostate cancer cells aswell as in several extraprostatic tissues. Mouse monoclonal antibody 4G5 specific to the extracellular domainof PSMA was used to screen two phage displayed peptide libraries (9aa linear and 9aa cys library). Three 4G5reactive phagotopes were identified. Sequence analysis ofisolated clones demonstrated that the interaction motif'VDPA/SK' has high homology to 719-725aa on PSMA.Immunohistochemical staming of the prostate cancer sam ple with the PSMA-mimic phagotope (mimotope) immunized serum antibodies demonstrate that the mimotopeisolated from the phage displayed peptide libraries can induce PSMA specific immune response in vivo.
文摘BERNARDO Bertolucci’s film, The Last Emperor, drew its Western audience into a mystic, grandiose, oriental palace that was the Forbidden City, leaving them awestruck at the
基金The Science and Technology Project Foundation of Guangzhou,China(Grant No.201604020106)Natural Science Foundation of Guangdong Province(Grant No.1814050002837)
文摘The primers were designed according to the gene sequence of lipocalin protein family,and the gene sequence containing random mutation protein was obtained by overlapping extension of PCR.The random mutation lipocalin library was constructed using phagemid expression vector.Lipocalin library was screened by subtracted screening of NSF60 cells and affinity screening of mast cells,and the lipocalin secondary library binding to mast cells was obtained.Then the lipocalin secondary library was enriched and screened with FcεRI-αreceptor protein as target molecule,and specific binding phages were eluted.After three rounds of screening,eight recombinant phage clones were randomly selected from elution clones of the third round.ELISA assay showed that three anticalin molecules could specifically bind to the FcεRI-αreceptor of mast cells.These results may provide some candidate biological molecules for the development of blocking drugs of mast cell FcεRI-αreceptor,and also lay the foundation for the development of biological small molecule drugs to treat Ig E associated allergic diseases.
文摘A library of 2 ×107 random octapeptides was constructed by use of phagemid-based monovalent phage display system. The randomly synthesized degenerated oligodeoxyribonucleotides (oligos ) were fused to the truncated g Ⅲ (p230-p403). Sequence analysis of 11 randomly chosen clones suggested that the degenerated inserts and its deduced amino acid (aa) sequences are randomly distributed. The library was used to select binding peptides to the monoclonal antibody (mAb) 9E10, which recognizes a continuous decapeptide epi- tope of denatured human c-myc protein. After four to five rounds of panning, most of the eluted clones could bind to 9E10. Sequence analysis of the selected positive clones indicated that the binding sequences could fall into two classes, one class (clone 1) shares a consensus motif, ISE x x L, with c-myc decapeptide; and the sequences of the other class are entirely different. The binding of both classes to 9E10 could be specifically inhibited by free c-myc decapeptide. The immunogenicity of the phage peptide was further investigated by construction of multivalent displayed phage peptides and immunization of animals with or without adjuvant. ELISA and competitive ELISA showed that anti-serum from both mice and rabbit immunized with either clone could bind to the original antigen, c-myc decapeptide. These results denote that in spite of the dissimilarity of the selected peptides with c-myc decapeptide, they are capable of inducing similar immune respones in vivo, thus actually mimicking the antigen epitope.
基金financially supported by the National Natural Science Foundation of China(Grant 32102258)the Project Funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions(020809008).
文摘Haloxyfop-P-methyl,a widely used aryloxyphenoxypropionate herbicide,has been identified as a potential hazard to ecological security and human health.Consequently,it is essential to develop superior methods for detecting haloxyfop-P-methyl.In this study,12 peptidomimetics and 4 anti-immunocomplex peptides were isolated from phage-displayed peptide libraries,which can specifically recognize the anti-haloxyfop-P-methyl antibody and the immunocomplex formed by haloxyfop-P-methyl and its antibody,respectively.Following the sensitivity assessment of each phage-displayed peptide,competitive and noncompetitive phage enzyme-linked immunosorbent assays(P-ELISAs)were developed using the best phage-displayed peptides.The half inhibition concentration(IC50)and half saturation concentration(SC50)of competitive and noncompetitive P-ELISAs were determined to be 8.15 and 1.83 ng/mL,respectively,representing the 5-fold and 22-fold increase in sensitivity compared to previously reported immunoassay.The competitive P-ELISA exhibited 2.2%-114.8% crossreactivities(CRs)to haloxyfop-methyl,haloxyfop and quizalofop-p-ethyl,while the noncompetitive P-ELISA showed no significant CR(<0.1%)except for haloxyfop-methyl(CR=41.6%).The average recoveries of two PELISAs in soil,soybean,potato,and cabbage samples ranged from 78.4% to 104.3% and 76.8%-95.2%,respectively.Additionally,the results of P-ELISAs for blind samples exhibited a good correlation with those obtained from ultra-performance liquid chromatography/tandem mass spectrometry.
基金supported by the Natural Science Foundation of the Jiangsu Higher Education Institutions of China(Grant No.22KJB310001 to W.G.)the Special Project of the Jiangsu Provincial Department of Science and Technology(Grant No.BE2023603 to W.G.)the Nanjing Medical University Science and Technology Development Foundation(Grant No.NMUB20210006 to W.G.).
文摘Neutralizing antibodies are essential tools in antiviral therapy and epidemic preparedness,capable of directlyinhibiting viral entry and limiting disease progression.However,traditional antibody discovery strategies—suchas animal immunization or B cell isolation from infected individuals—are often hindered by biosafety concerns,lengthy development timelines,and limited adaptability during outbreaks.In the present study,we aimed toestablish a robust and rapid in vitro platform for the efficient isolation of neutralizing antibodies targetingconserved viral epitopes.We developed an epitope-guided negative screening strategy that integrates phagedisplay technology with rational antigen mutagenesis to exclude antibodies against variable regions whileenriching for those that recognize functionally constrained epitopes.When applied to the receptor-binding domainof severe acute respiratory syndrome coronavirus 2,this method enabled the identification of six neutralizingantibodies(one IgG and five nanobodies)exhibiting broad-spectrum neutralizing activity across multiple viralvariants.Notably,antibodies recognizing distinct epitopes demonstrated significant synergistic neutralizationwhen used in combination(P<0.05).This screening approach facilitates the rapid discovery of potent andmutation-resistant antibodies and holds promise for application to other emerging pathogens.Our findingsunderscore the potential of epitope-guided,in vitro platforms in expediting therapeutic antibody developmentunder conditions of high biosafety requirements.
基金supported by the National Natural Science Foundation of China(Grant No.22105106)the Jiangsu Youth Science and Technology Talent Support Program(Grant No.JSTJ-2025-063)+1 种基金Nanjing Science and Technology Innovation Project for Overseas Students(Grant No.NJKCZYZZ2022-05)Start-up Funding from NUPTSF(Grant No.NY221003).
文摘In an era dominated by visual information,the display interface serves as a critical gateway between the human and digital worlds.The relentless pursuit of visual immersion has driven display technology from cinema screens to smart-phones and now to virtual and augmented reality(VR/AR)headsets,progressively moving closer to the human eye.This evolution places unprecedented demands on pixel density,power efficiency,and form factor,pushing up against funda-mental physical and physiological limits.
文摘As the sunlight scattered on the sea of Guanyinshan in Xiamen,a space that bridges creativity and industry opened its door to the world.On December 15th,following a ribbon-cutting and unveiling ceremony,YKK Xiamen Guanyinshan Showroom,the brand's second and largest comprehensive showroom,was officially inaugurated.This showroom is more than a product display window,it is an"Inspiration Hub"integrating exhibition,co-creation,and service.Its launch signifies YKK's progression in the Chinese market from“building an efficient product proposal system”to a new stage of“deep collaborative co-creation.”
基金supported by the National Natural Science Foundation of China(Nos.12175321,W2443004,11975021,11675275,U1932101)Strategic Priority Research Program of the Chinese Academy of Sciences(No.XDA10010900)+2 种基金National Key Research and Development Program of China(Nos.2023YFA1606000 and 2020YFA0406400)National College Students Science and Technology Innovation ProjectUndergraduate Base Scientific Research Project of Sun Yat-sen University。
文摘Detector and event visualization are crucial components of high-energy physics(HEP)experimental software.Virtual reality(VR)technologies and multimedia development platforms,such as Unity,offer enhanced display effects and flexible extensibility for visualization in HEP experiments.In this study,we present a VR-based method for detector and event displays in the Jiangmen Underground Neutrino Observatory(JUNO)experiment.This method shares the same detector geometry descriptions and event data model as those in the offline software and provides the necessary data conversion interfaces.The VR methodology facilitates an immersive exploration of the virtual environment in JUNO,enabling users to investigate the detector geometry,visualize event data,and tune the detector simulation and event reconstruction algorithms.Additionally,this approach supports applications in data monitoring,physics data analysis,and public outreach initiatives.
基金funding provided by National Natural Science Foundation of China(U21A20140)National Key Research and Development Program of China(2021YFA1401200)+2 种基金Beijing Natural Science Foundation(JQ24028)Beijing Nova Program(20240484557)Synergetic Extreme Condition User Facility(SECUF).
文摘The advent of artificial intelligence(AI)has propelled augmented reality(AR)display technology to a pivotal juncture,positioning it as a contender for the next generation of mobile intelligent terminals.However,the pursuit of advanced AR displays,particularly those capable of delivering immersive 3D experiences,is significantly hindered by the performance limitations of current hardware and the complexity of system integration.In this study,we present an innovative multi-focal plane AR display system that integrates a non-orthogonal polarization-multiplexing metasurface,freeform optical elements,and an OLED display screen.All optical elements are integrated into a single solid-state architecture,based on a joint optimization design approach of ray tracing and diffraction theory.The multi-focal plane AR visual effect is realized by the compact and multiplexing metasurface,which performs distinct phase functions across diverse polarization channels.Meanwhile,freeform surfaces offer ample design flexibility for the collaborative optimization of multi-focal plane imaging and the see-through systems.Followed by a mechanical design and prototype assembly,we demonstrate the system's capabilities in real-time and multi-focal plane display.The digital images at all virtual image distances seamlessly integrate with the real environment,fully exhibiting the system's high parallelism and real-time interactivity.With the innovative design concept and joint design method,we believe that our work will spur more innovative and compact intelligent solutions for AR displays and inject new vitality into hybrid optical systems.
基金supported by the National Key Research and Development Program of China(Grant No.2022YFB3607300)the National Natural Science Foundation of China(Grant Nos.62322512,62225506,and 12134013)+7 种基金the Fundamental Research Funds for the Central Universities(Grant Nos.WK2030000108 and WK2030000090)the CAS Project for Young Scientists in Basic Research(Grant No.YSBR-049)supported by the National Natural Science Foundation of China(Grant Nos.12174260 and 12574326)the Shanghai Rising-Star Program(Grant No.21QA1406400)the Shanghai Science and Technology Development Fund(Grant Nos.21ZR1443500 and 21ZR1443600)the support from the China Postdoctoral Science Foundation(Grant No.2023M743364)support from the Center for Micro and Nanoscale Research and Fabrication,University of Science and Technology of Chinasupported by the UPOLabs,which provided the experimental and technical support。
文摘Head-up displays(HUDs)are emerging as key components of intelligent vehicles,requiring wide-depth,large-area,and high-efficiency dynamic imaging,which remains difficult to realize with traditional refractive optics.Computer-generated holography(CGH)with diffraction optics offers a promising solution to these technical demands.However,CGH optimization based on the fast Fourier transform(FFT)faces limitations such as zero-padding redundancy,coupled sampling intervals,and incompatible near-and farfield propagation models.Here,we report a holography-based multiplane HUD using a matrix multiplication(MM)-assisted diffraction algorithm that restructures the Fresnel integral into two sequential matrix operations,thus eliminating zero-padding and enabling fully decoupled sampling between object and image planes.Compared with FFT-based angular spectrum methods,the MM approach significantly improves computational speed and memory efficiency for hologram design,which is validated by demonstrating dual-plane holography with a size ratio exceeding 100:1 and unified reconstruction across Fresnel and Fraunhofer regimes within a single computation.A prototype HUD system is demonstrated successfully to exhibit multiple-plane holographic virtual images that can be mixed with real-world objects at three independent planes.The technique might be one of the potential candidates for next-generation intelligent vehicle displays.
基金supports from the National Natural Science Foundation of China(62105185,52202320)the“Qilu Young Scholar”program(62460082163097)of Shandong University,open foundation of the State Key Laboratory of Vanadium and Titanium Resources Comprehensive Utilization(2023P4FZG08A)+1 种基金Fundamental Research Funds for the Central Universities(No.862201013153)Shandong Excellent Young Scientists Fund Program(Overseas)(2023HWYQ-060).
文摘Unlike conventional electrochromic devices,Zinc anode-based electrochromic devices(ZECDs)ensure excellent charge balance between the electrochromic layer and Zn anode during the coloring/bleaching by reversible metal deposition/stripping on the Zn anode.Meanwhile,the inherent potential difference between the metal anode and the electrochromic layer can drive the spontaneous coloration/bleaching of ZECDs,featuring energy retrieval functionality.This review discusses the working mechanisms,performance indexes of ZECDs,and the impact of material selection on ZECD performance.Furthermore,we comprehensively summarize the latest research progress of ZECDs in energy storage,smart windows,and multicolor displays.We argue that using high-transparency zinc mesh,additive manufacturing processes,and self-healing electrochromic materials can significantly advance the commercialization of large-area ZECDs.Finally,“electrode-free”device structures,renewable or replaceable electrolytes,and strategies to suppress zinc dendrites are prospected to overcome cost-effectiveness and lifespan issues of ZECDs.This review aims at enabling more efficient and advanced ZECDs for multifunctional applications.
文摘To address the challenges of complexity,power consumption,and cost constraints in traditional display driver integrated circuits(DDICs)caused by external NOR Flash and SRAM,this work proposes an embedded resistive random-access memory(RRAM)integration solution based on a 40 nm high-voltage CMOS logic platform.Targeting the yield fluctuations and stability challenges during RRAM mass production,systematic process optimizations are implemented to achieve synergistic improvements in RRAM performance and yield.Through modifications to the film sputtering and pre-deposition treatment,the withinwafer resistance uniformity(RSU)of the oxygen-deficient layer(ODL)thin film is improved from 11%to 8%,while inter-wafer process stability variation reduces from 23%to below 6%.Consequently,the yield of 8 Mb RRAM embedded mass production products increases from 87%to 98.5%.In terms of device performance,the RRAM demonstrates a fast 4.8 ns read speed,exceptional read disturb immunity of 3×10^(8) cycles at 95℃,10^(3) write/erase endurance cycles for the 1 Mb cells,and data retention of 12.5 years at 125℃.Post high-temperature operating life(HTOL)testing exhibits stable high/low resistance window.This study provides process optimization strategies and a reliability assurance framework for the mass production of highly integrated,low-power embedded RRAM display driver IC.
基金financial support received from the Shanghai Pujiang Program(23PJ1406500)。
文摘White Cyphochilus insulanus beetles,exhibiting both environmental camouflage display and radiative cooling functions,serve as a good prototype for biomimetic fabrication.As inspired,this work presents a femtosecond(fs)laser-based biomimetic fabrication strategy that takes full use of the synthesized radiative cooling nanomaterials for a groundbreaking stimuli-responsive infrared(IR)impressionistic camouflage display.The proposed technique is capable of readily transforming various substrates(quartz glass and metals including Ti,Al,Zr,and W)into self-assembled porous networks(aerogels)consisting of oxygen-vacancy-rich oxide nanoparticles.Surprisingly,the emissions of all as-prepared porous particle-networks in the radiative-cooling long-wavelength infrared(LWIR)band are above 95%,with the SiO_(2) aerogels reaching a maximum of 99.6%.Benefiting from the far-from-equilibrium thermodynamic kinetics,metastable phases of anatase TiO_(2),tetragonal zirconia(t-ZrO_(2)),and monoclinic WO_(3)(Pc)are synthesizable,opening up opportunities for exploring their optical applications.Taking the low-temperature metastable phase WO_(3)(Pc)as representative for systematic studies,it is found that(1)the ratio WO_(3)(Pc)phase to that of room-temperature phase of WO_(3)(P2_(1)/n)can be tailored by modulation of processing parameters;(2)laser synthesized aerogels with hybrid phases of WO_(3)(Pc)and WO_(3)(P2_(1)/n)have a brighter visible whiteness,higher visible/nearinfrared(NIR)spectral selectivity than the natural prototype of white Cyphochilus insulanus beetles but with comparable LWIR emittance.White WO_(3) aerogel in situ deposited during flexibly fs laser artistic patterning can blur the painting features due to its radiative cooling effect,allowing a colorful impressionistic IR display in the heating mode.What's more,invisible painting features concealed by the white deposited WO_(3) aerogel are clearly/faintly distinguishable by introducing external stimuli of a human hand and sample heating,respectively,catalyzing progress in optical encryption and selectively stimuli-responsive decryption display in the infrared band.
文摘China’s 30 plus provinces,municipalities and autonomous regions take turns showcasing their culture and customs at the ongoing World Expo in Shanghai. Beijing took the lead by hosting Beijing Week in May. Since then,many local arts have been featured,such as the New Year paintings of Tianjin’ s Yangliuqing Town,the pastoral songs of the Inner Mongolia Autonomous Region,the song-and-dance duet popular in northeast China and the acrobatics of Hebei’ s Wuqiao County.
文摘Ford Motor,for the first time,displayed its globalproducts at the 8th Beijing Intemational Motor Show on June8 with its new generation Focus concept car making a globaldebut. The exhibits included the vehicles designed andmanufactured in North America,Europe and Australia.Ford,
