A prestigious conference claimed recently a revolution in neuroscience to understand consciousness.In this paper it is shown that this revolution already came,revealing the determinant role of information for human an...A prestigious conference claimed recently a revolution in neuroscience to understand consciousness.In this paper it is shown that this revolution already came,revealing the determinant role of information for human and living structures,both for their structuration and behavior,explaining consciousness at human as the result of the activity of the Informational System of Human and Living Structures.For this,it is emphasized and discussed the informational structure of the eukaryotic cell,the basic/representative composing unit of the multicellular body of human,animals,and plants,showing that the composition and functions of the informational system are basically similar with that of human.To reveal the driving role of informational mechanisms in human and subhuman organisms,it is introduced the concept of matter-related information,showing that information can be hidden/“embodied”or released/“disembodied”in or from the elemental micro/macro components of the body,during the multiple chain/cascade interactions including transduction processes.It is shown that such interactions are initiated from two main categories of informational sources:implicit(genetic)and explicit(external/internal)sources,the first category leading to structuration of the body and the second the reactive behavior.Consciousness in human and subhuman organisms,expressed by two corresponding informational relations,is the result of the release of information by the mind,acting as an informational operator/device,the development degree of mind and consciousness depending on the complexity degree and adaptation.An analogy of this Informational Model of Human and Living Structures(IMHLS)with the ancient model of chakras is highlighted,showing that these models support each other,applied with beneficial effects in Reiki technique and music-based cognitive multi-task therapy for neuro-rehabilitation.展开更多
RNA N6-methyladenine(m^(6)A)modification represents a pivotal epigenetic modification that facilitates the remodeling of gene expression and regulates a variety of biological processes via certain post-transcriptional...RNA N6-methyladenine(m^(6)A)modification represents a pivotal epigenetic modification that facilitates the remodeling of gene expression and regulates a variety of biological processes via certain post-transcriptional mechanisms.However,the specific function of RNA m^(6)A modification in insect male reproduction remains unclear.In this study,we explored the molecular mechanism by which METTL3/METTL14-mediated RNA m^(6)A modification regulates male reproduction in the invasive pest Bactrocera dorsalis.The results showed that BdMettl3 and BdMettl14 were highly expressed in fat body(FB)and male accessory glands(MAGs).Knockout of BdMettl3 or BdMettl14 decreased the expression level of m^(6)A in B.dorsalis,resulting in testicular deformities and a significant reduction of viable sperm number.Specifically,BdMettl3 or BdMettl14 knockout reduced the titer of 20-hydroxyecdysone(20E,the active form of ecdysone)in males.The messenger RNA(mRNA)of Disembodied,one of the 20E synthesis genes,was modified by m^(6)A,and its expression increased the titer of 20E.The mRNA m^(6)A level of Disembodied obviously decreased after the knockout of BdMettl3 or BdMettl14,suggesting that RNA m^(6)A modification regulates testis development and fecundity by modulating 20E synthesis.Taken together,this study indicates that METTL3/METTL14-mediated RNA m^(6)A modification presents a new regulatory mechanism for male reproduction in B.dorsalis,serving as a potential target for the control of B.dorsalis.展开更多
文摘A prestigious conference claimed recently a revolution in neuroscience to understand consciousness.In this paper it is shown that this revolution already came,revealing the determinant role of information for human and living structures,both for their structuration and behavior,explaining consciousness at human as the result of the activity of the Informational System of Human and Living Structures.For this,it is emphasized and discussed the informational structure of the eukaryotic cell,the basic/representative composing unit of the multicellular body of human,animals,and plants,showing that the composition and functions of the informational system are basically similar with that of human.To reveal the driving role of informational mechanisms in human and subhuman organisms,it is introduced the concept of matter-related information,showing that information can be hidden/“embodied”or released/“disembodied”in or from the elemental micro/macro components of the body,during the multiple chain/cascade interactions including transduction processes.It is shown that such interactions are initiated from two main categories of informational sources:implicit(genetic)and explicit(external/internal)sources,the first category leading to structuration of the body and the second the reactive behavior.Consciousness in human and subhuman organisms,expressed by two corresponding informational relations,is the result of the release of information by the mind,acting as an informational operator/device,the development degree of mind and consciousness depending on the complexity degree and adaptation.An analogy of this Informational Model of Human and Living Structures(IMHLS)with the ancient model of chakras is highlighted,showing that these models support each other,applied with beneficial effects in Reiki technique and music-based cognitive multi-task therapy for neuro-rehabilitation.
基金supported by the National Natural Science Foundation of China(no.32220103009)Earmarked Fund for China Agriculture Research System(CARS-26)Hubei Hongshan Laboratory.
文摘RNA N6-methyladenine(m^(6)A)modification represents a pivotal epigenetic modification that facilitates the remodeling of gene expression and regulates a variety of biological processes via certain post-transcriptional mechanisms.However,the specific function of RNA m^(6)A modification in insect male reproduction remains unclear.In this study,we explored the molecular mechanism by which METTL3/METTL14-mediated RNA m^(6)A modification regulates male reproduction in the invasive pest Bactrocera dorsalis.The results showed that BdMettl3 and BdMettl14 were highly expressed in fat body(FB)and male accessory glands(MAGs).Knockout of BdMettl3 or BdMettl14 decreased the expression level of m^(6)A in B.dorsalis,resulting in testicular deformities and a significant reduction of viable sperm number.Specifically,BdMettl3 or BdMettl14 knockout reduced the titer of 20-hydroxyecdysone(20E,the active form of ecdysone)in males.The messenger RNA(mRNA)of Disembodied,one of the 20E synthesis genes,was modified by m^(6)A,and its expression increased the titer of 20E.The mRNA m^(6)A level of Disembodied obviously decreased after the knockout of BdMettl3 or BdMettl14,suggesting that RNA m^(6)A modification regulates testis development and fecundity by modulating 20E synthesis.Taken together,this study indicates that METTL3/METTL14-mediated RNA m^(6)A modification presents a new regulatory mechanism for male reproduction in B.dorsalis,serving as a potential target for the control of B.dorsalis.
