<span style="font-family:Verdana;">The effects of microorganisms on the central nervous system are manifested in both health and disease states. The symbiotic microorganisms in the human gut have certa...<span style="font-family:Verdana;">The effects of microorganisms on the central nervous system are manifested in both health and disease states. The symbiotic microorganisms in the human gut have certain effects on the brain development before and after birth. Chronic inflammation in patients with irritable bowel syndrome (IBS), psychiatric disorders such as PTSD, anxiety disorders, etc., is likely to be associated with an imbalance in gut flora. Intestinal flora regulates the central nervous system mainly through nerve, endocrine, metabolic and immune pathways. The mechanisms involved in the influence of intestinal flora on the central nervous system are diverse, so it is necessary to explore the role of intestinal flora in mental and psychological diseases.</span>展开更多
In order to investigate the sleep quality and influencing factors in patients with Parkinson＇s disease（PD）, 201 PD patients were enrolled and underwent extensive clinical evaluations. Subjective sleep evaluation wa...In order to investigate the sleep quality and influencing factors in patients with Parkinson＇s disease（PD）, 201 PD patients were enrolled and underwent extensive clinical evaluations. Subjective sleep evaluation was assessed using the Pittsburgh Sleep Quality Index（PSQI）, and the Epworth Sleepiness Scale（ESS）. It was found that poor sleep quality（77.11%） and excessive daytime sleepiness（32.34%） were commonly seen in PD patients and positively correlated with disease severity. Then 70 out of the 201 PD patients and 70 age- and sex-matched controls underwent a polysomnographic recording. The parameters were compared between PD group and control group and the influencing factors of sleep in PD patients were analyzed. The results showed that sleep efficiency（SE） was significantly decreased（P〈0.01）, and sleep latency（SL） and the arousal index（AI） were increased（P〈0.05） in the PD group as compared with those in the control group. SE and total sleep time（TST） were positively correlated with the Hoehn and Yahr（H＆Y） stage. There was significant difference in the extent of hypopnea and hypoxemia between the PD group and the control group（P〈0.05）. Our results indicate that PD patients have an overall poor sleep quality and a high prevalence of sleep disorder, which may be correlated with the disease severity. Respiratory function and oxygen supply are also affected to a certain degree in PD patients.展开更多
Pancreatic ductal adenocarcinoma(PDAC)is a highly aggressive malignancy with a poor prognosis,particularly in the presence of liver metastases.The mechanisms by which metabolic dysfunction-associated steatotic liver d...Pancreatic ductal adenocarcinoma(PDAC)is a highly aggressive malignancy with a poor prognosis,particularly in the presence of liver metastases.The mechanisms by which metabolic dysfunction-associated steatotic liver disease(MASLD),formerly known as nonalcoholic fatty liver disease(NAFLD),influences PDAC progression and metastasis remain poorly understood.This study investigates the role of MASLD in fostering an immunosuppressive microenvironment conducive to PDAC liver metastases and identifies the macrophage migration inhibitory factor(MIF)-CD44 axis as a key mediator of this process.Utilizing data from the UK Biobank(450,754 participants,median follow-up 14.5 years),we observed an overall increased risk of PDAC in the MASLD population(HR:3.48;95%CI:2.69-4.50;P<0.0001).Clinical cohorts confirmed the strong association between MASLD and hepatic metastases(OR:7.06;95%CI:4.62-10.78;P<0.0001).Experimental mouse models demonstrated that MASLD enhances tumor cell stemness,immune evasion,and focal adhesion in metastatic liver tissues.Mechanistically,MASLD-induced MIF secretion promotes CD44-positive PDAC cell migration,stemness,and adhesion.Targeting MIF,either genetically or pharmacologically using the MIF tautomerase inhibitor IPG1576 significantly attenuated liver metastasis in preclinical models.Validation in patient samples revealed elevated hepatic MIF and CD44 expression in MASLD-associated PDAC liver metastases.This study highlights the MIF-CD44 axis as a promising therapeutic target and underscores the importance of tailoring treatments for PDAC patients with concurrent MASLD.展开更多
文摘<span style="font-family:Verdana;">The effects of microorganisms on the central nervous system are manifested in both health and disease states. The symbiotic microorganisms in the human gut have certain effects on the brain development before and after birth. Chronic inflammation in patients with irritable bowel syndrome (IBS), psychiatric disorders such as PTSD, anxiety disorders, etc., is likely to be associated with an imbalance in gut flora. Intestinal flora regulates the central nervous system mainly through nerve, endocrine, metabolic and immune pathways. The mechanisms involved in the influence of intestinal flora on the central nervous system are diverse, so it is necessary to explore the role of intestinal flora in mental and psychological diseases.</span>
基金supported by grants from the National Natural Science Foundation of China(No.30700244)the Natural Science Foundation of Hubei Province(No.2012FFB02501)
文摘In order to investigate the sleep quality and influencing factors in patients with Parkinson＇s disease（PD）, 201 PD patients were enrolled and underwent extensive clinical evaluations. Subjective sleep evaluation was assessed using the Pittsburgh Sleep Quality Index（PSQI）, and the Epworth Sleepiness Scale（ESS）. It was found that poor sleep quality（77.11%） and excessive daytime sleepiness（32.34%） were commonly seen in PD patients and positively correlated with disease severity. Then 70 out of the 201 PD patients and 70 age- and sex-matched controls underwent a polysomnographic recording. The parameters were compared between PD group and control group and the influencing factors of sleep in PD patients were analyzed. The results showed that sleep efficiency（SE） was significantly decreased（P〈0.01）, and sleep latency（SL） and the arousal index（AI） were increased（P〈0.05） in the PD group as compared with those in the control group. SE and total sleep time（TST） were positively correlated with the Hoehn and Yahr（H＆Y） stage. There was significant difference in the extent of hypopnea and hypoxemia between the PD group and the control group（P〈0.05）. Our results indicate that PD patients have an overall poor sleep quality and a high prevalence of sleep disorder, which may be correlated with the disease severity. Respiratory function and oxygen supply are also affected to a certain degree in PD patients.
基金supported by the National Natural Science Foundation of China(82125026,82303933,82330081)(HR,QY)Natural Science Foundation of Shandong Province(ZR2022QH241)(QY)+3 种基金“Intergovernmental International Cooperation on Science and Technology Innovation”Key Special Project of China(No.2024YFE0104100)(HR)Medicine Plus’Joint Research Program of Qingdao University(YX2024201)(HR)We would like to thank Mr.Duo Cai from Medical Research Center of the Affiliated Hospital of Qingdao University,the research laboratory directed by Professor Wang Yibing,Jinan,Shandong,the First Affiliated Hospital of Shandong First Medical University,Shandong Provincial Qianfoshan Hospital,for their supporting on experimental instruments.ChatGPT assisted in the language editing of this paper.Our work was preprinted on BioRxiv on June 3rd,2024(https://doi.org/10.1101/2024.06.02.595997)Preprints with THE LANCET on July 16th,2024(https://doi.org/10.2139/ssrn.4894825).
文摘Pancreatic ductal adenocarcinoma(PDAC)is a highly aggressive malignancy with a poor prognosis,particularly in the presence of liver metastases.The mechanisms by which metabolic dysfunction-associated steatotic liver disease(MASLD),formerly known as nonalcoholic fatty liver disease(NAFLD),influences PDAC progression and metastasis remain poorly understood.This study investigates the role of MASLD in fostering an immunosuppressive microenvironment conducive to PDAC liver metastases and identifies the macrophage migration inhibitory factor(MIF)-CD44 axis as a key mediator of this process.Utilizing data from the UK Biobank(450,754 participants,median follow-up 14.5 years),we observed an overall increased risk of PDAC in the MASLD population(HR:3.48;95%CI:2.69-4.50;P<0.0001).Clinical cohorts confirmed the strong association between MASLD and hepatic metastases(OR:7.06;95%CI:4.62-10.78;P<0.0001).Experimental mouse models demonstrated that MASLD enhances tumor cell stemness,immune evasion,and focal adhesion in metastatic liver tissues.Mechanistically,MASLD-induced MIF secretion promotes CD44-positive PDAC cell migration,stemness,and adhesion.Targeting MIF,either genetically or pharmacologically using the MIF tautomerase inhibitor IPG1576 significantly attenuated liver metastasis in preclinical models.Validation in patient samples revealed elevated hepatic MIF and CD44 expression in MASLD-associated PDAC liver metastases.This study highlights the MIF-CD44 axis as a promising therapeutic target and underscores the importance of tailoring treatments for PDAC patients with concurrent MASLD.
