Objective： To observe the effect of electroacupuncture （EA） gait function, and expression levels of serum immunoglobul intervertebral disc herniation （LIDH）. at Huantiao （GB 30） and Weizhong （BL 40） on thigme...Objective： To observe the effect of electroacupuncture （EA） gait function, and expression levels of serum immunoglobul intervertebral disc herniation （LIDH）. at Huantiao （GB 30） and Weizhong （BL 40） on thigmesthesia, n G （IgG） and immunoglobulin M （IgM） in rabbits with lumbar Methods： Forty healthy New Zealand rabbits were randomly divided into a blank control group, a model group, an EA at acupoint group and an EA at non-acupoint group, with 10 rabbits in each group. The LIDH pathological model of rabbit was established using the self-made LIDH model maker. The thigmesthesia and gait function of rabbits were recorded by Siegal method. The serum IgG and IgM expression levels were detected by enzyme-linked immunosorbent assay. Results： EA at Huantiao （GB 30） and Weizhong （BL 40） could improve the clinical symptoms of thigmesthesia and gait function, and inhibit the expressions of serum IgG and IgM in the LIDH rabbits, which were significantly different compared with those in the model group and EA at non-acupoint group. Conclusion： EA at Huantiao （GB 30） and Weizhong （BL 40） can improve the clinical symptoms of LIDH rabbits, which is associated with inhibition of the serum IgG and IgM expressions and reduction of the immunoinflammatory factor release. This may be one of the mechanisms of EA at Huantiao （GB 301 and Weizhong[BL 407 in the treatment of LIDH.展开更多
基金supported by Scientific Research Project of Hunan Provincial Administration of Traditional Chinese Medicine,No.201378~~
文摘Objective： To observe the effect of electroacupuncture （EA） gait function, and expression levels of serum immunoglobul intervertebral disc herniation （LIDH）. at Huantiao （GB 30） and Weizhong （BL 40） on thigmesthesia, n G （IgG） and immunoglobulin M （IgM） in rabbits with lumbar Methods： Forty healthy New Zealand rabbits were randomly divided into a blank control group, a model group, an EA at acupoint group and an EA at non-acupoint group, with 10 rabbits in each group. The LIDH pathological model of rabbit was established using the self-made LIDH model maker. The thigmesthesia and gait function of rabbits were recorded by Siegal method. The serum IgG and IgM expression levels were detected by enzyme-linked immunosorbent assay. Results： EA at Huantiao （GB 30） and Weizhong （BL 40） could improve the clinical symptoms of thigmesthesia and gait function, and inhibit the expressions of serum IgG and IgM in the LIDH rabbits, which were significantly different compared with those in the model group and EA at non-acupoint group. Conclusion： EA at Huantiao （GB 30） and Weizhong （BL 40） can improve the clinical symptoms of LIDH rabbits, which is associated with inhibition of the serum IgG and IgM expressions and reduction of the immunoinflammatory factor release. This may be one of the mechanisms of EA at Huantiao （GB 301 and Weizhong[BL 407 in the treatment of LIDH.
