目的观察电针联合悬吊训练(sling exercise therapy,SET)治疗慢性非特异性下腰痛(chronic nonspecific low back pain,CNLBP)的临床疗效。方法将72例CNLBP患者随机分为观察组和对照组,每组36例。对照组行SET治疗,观察组在对照组基础上...目的观察电针联合悬吊训练(sling exercise therapy,SET)治疗慢性非特异性下腰痛(chronic nonspecific low back pain,CNLBP)的临床疗效。方法将72例CNLBP患者随机分为观察组和对照组,每组36例。对照组行SET治疗,观察组在对照组基础上采用电针腰夹脊穴治疗。观察两组治疗前后视觉模拟评分法(visual analog scale,VAS)、腰椎功能障碍指数(oswestry disability index,ODI)、日本骨科协会(Japanese Orthopaedc Association,JOA)评分的变化,并比较两组治疗前后竖脊肌、多裂肌表面肌电图(surface electromyography,sEMG)中的指标均方根值(root mean square,RMS)和中位频率值(median frequency value,MF)。结果两组治疗2周后VAS、ODI评分低于治疗前,治疗后VAS、ODI评分低于治疗2周后和治疗前,差异有统计学意义(P<0.05);观察组治疗2周后和治疗后VAS、ODI评分低于对照组,差异有统计学意义(P<0.05)。两组治疗2周后JOA评分高于治疗前,治疗后JOA评分高于治疗2周后和治疗前,差异有统计学意义(P<0.05);观察组治疗2周后和治疗后JOA评分高于对照组,差异有统计学意义(P<0.05)。对照组竖脊肌、多裂肌双侧RMS值治疗2周后与治疗前比较,差异无统计学意义(P>0.05);治疗后竖脊肌、多裂肌双侧RMS值高于治疗2周后和治疗前,差异有统计学意义(P<0.05);观察组治疗2周后竖脊肌、多裂肌双侧RMS值高于治疗前,治疗后竖脊肌、多裂肌双侧RMS值高于治疗2周后和治疗前,差异有统计学意义(P<0.05);观察组治疗2周后、治疗后竖脊肌和多裂肌双侧RMS值高于对照组,差异有统计学意义(P<0.05)。两组治疗2周后竖脊肌、多裂肌双侧MF值高于治疗前,治疗后竖脊肌、多裂肌双侧MF值高于治疗2周后和治疗前,差异有统计学意义(P<0.05);观察组治疗2周后和治疗后竖脊肌、多裂肌双侧MF值高于对照组,差异有统计学意义(P<0.05)。结论电针联合SET训练能更好地减轻患者疼痛,改善椎旁核心肌(多裂肌、竖脊肌)的肌电信号,促进腰椎核心肌群功能恢复。展开更多
Background:Ex vivo lung perfusion(EVLP)has emerged as a critical technique for lung preservation and evaluation prior to transplantation.While conventional rat EVLP systems utilize closed-loop dual cannulation of pulm...Background:Ex vivo lung perfusion(EVLP)has emerged as a critical technique for lung preservation and evaluation prior to transplantation.While conventional rat EVLP systems utilize closed-loop dual cannulation of pulmonary artery(PA)and vein,the effect of the simplified model using single PA cannulation with passive venous drainage is unknown.Methods:We developed two EVLP models in rats:a semi-closed circuit with PA-only cannulation and left atrial incision for passive venous drainage(SC-EVLP),and a closed circuit employing both arterial and venous cannulation(C-EVLP).Donor lungs were perfused for a defined duration and subsequently orthotopically transplanted.We evaluated pulmonary function parameters,histopathological injury scores,inflammatory cytokine levels,and apoptotic marker expression at the end of perfusion and posttransplantation.Results:Compared to the conventional EVLP,the SC-EVLP group exhibited significantly lower PA pressure and improved dynamic lung compliance throughout perfusion.Although the levels of tumor necrosis factor-αin the perfusate were higher in the SC-EVLP group,other cytokine levels in the perfusate and bronchoalveolar lavage fluid exhibited no significant differences.Pulmonary edema was reduced in the SC-EVLP group,as indicated by a lower lung wet-to-dry ratio.After transplantation,lungs from the SC-EVLP group exhibited lower histological injury scores,reduced apoptosis,and decreased serum cytokine levels,suggesting attenuated inflammation and tissue damage.Conclusions:In a rat model,single PA cannulation with passive venous drainage reduced pulmonary edema during EVLP and reduced lung injury and systemic inflammation after transplantation.展开更多
文摘目的观察电针联合悬吊训练(sling exercise therapy,SET)治疗慢性非特异性下腰痛(chronic nonspecific low back pain,CNLBP)的临床疗效。方法将72例CNLBP患者随机分为观察组和对照组,每组36例。对照组行SET治疗,观察组在对照组基础上采用电针腰夹脊穴治疗。观察两组治疗前后视觉模拟评分法(visual analog scale,VAS)、腰椎功能障碍指数(oswestry disability index,ODI)、日本骨科协会(Japanese Orthopaedc Association,JOA)评分的变化,并比较两组治疗前后竖脊肌、多裂肌表面肌电图(surface electromyography,sEMG)中的指标均方根值(root mean square,RMS)和中位频率值(median frequency value,MF)。结果两组治疗2周后VAS、ODI评分低于治疗前,治疗后VAS、ODI评分低于治疗2周后和治疗前,差异有统计学意义(P<0.05);观察组治疗2周后和治疗后VAS、ODI评分低于对照组,差异有统计学意义(P<0.05)。两组治疗2周后JOA评分高于治疗前,治疗后JOA评分高于治疗2周后和治疗前,差异有统计学意义(P<0.05);观察组治疗2周后和治疗后JOA评分高于对照组,差异有统计学意义(P<0.05)。对照组竖脊肌、多裂肌双侧RMS值治疗2周后与治疗前比较,差异无统计学意义(P>0.05);治疗后竖脊肌、多裂肌双侧RMS值高于治疗2周后和治疗前,差异有统计学意义(P<0.05);观察组治疗2周后竖脊肌、多裂肌双侧RMS值高于治疗前,治疗后竖脊肌、多裂肌双侧RMS值高于治疗2周后和治疗前,差异有统计学意义(P<0.05);观察组治疗2周后、治疗后竖脊肌和多裂肌双侧RMS值高于对照组,差异有统计学意义(P<0.05)。两组治疗2周后竖脊肌、多裂肌双侧MF值高于治疗前,治疗后竖脊肌、多裂肌双侧MF值高于治疗2周后和治疗前,差异有统计学意义(P<0.05);观察组治疗2周后和治疗后竖脊肌、多裂肌双侧MF值高于对照组,差异有统计学意义(P<0.05)。结论电针联合SET训练能更好地减轻患者疼痛,改善椎旁核心肌(多裂肌、竖脊肌)的肌电信号,促进腰椎核心肌群功能恢复。
基金Key Science and Technology Program of Shaanxi Province,Grant/Award Number:2024SF2-GJHX-45National Natural Science Foundation of China,Grant/Award Number:82472191The Natural Science Foundation of Shaanxi Province,Grant/Award Number:2024JC-ZDXM-49。
文摘Background:Ex vivo lung perfusion(EVLP)has emerged as a critical technique for lung preservation and evaluation prior to transplantation.While conventional rat EVLP systems utilize closed-loop dual cannulation of pulmonary artery(PA)and vein,the effect of the simplified model using single PA cannulation with passive venous drainage is unknown.Methods:We developed two EVLP models in rats:a semi-closed circuit with PA-only cannulation and left atrial incision for passive venous drainage(SC-EVLP),and a closed circuit employing both arterial and venous cannulation(C-EVLP).Donor lungs were perfused for a defined duration and subsequently orthotopically transplanted.We evaluated pulmonary function parameters,histopathological injury scores,inflammatory cytokine levels,and apoptotic marker expression at the end of perfusion and posttransplantation.Results:Compared to the conventional EVLP,the SC-EVLP group exhibited significantly lower PA pressure and improved dynamic lung compliance throughout perfusion.Although the levels of tumor necrosis factor-αin the perfusate were higher in the SC-EVLP group,other cytokine levels in the perfusate and bronchoalveolar lavage fluid exhibited no significant differences.Pulmonary edema was reduced in the SC-EVLP group,as indicated by a lower lung wet-to-dry ratio.After transplantation,lungs from the SC-EVLP group exhibited lower histological injury scores,reduced apoptosis,and decreased serum cytokine levels,suggesting attenuated inflammation and tissue damage.Conclusions:In a rat model,single PA cannulation with passive venous drainage reduced pulmonary edema during EVLP and reduced lung injury and systemic inflammation after transplantation.
