A chemical investigation of secondary metabolites(SMs)from Aspergillus nidulans resulted in the identification of five novel dioxopiperazine(DKP)-diphenyl ether hybrids,designated as diphenylemestrins A-E(1-5).These c...A chemical investigation of secondary metabolites(SMs)from Aspergillus nidulans resulted in the identification of five novel dioxopiperazine(DKP)-diphenyl ether hybrids,designated as diphenylemestrins A-E(1-5).These compounds 1-5 represent the first known dimers combining DKP and diphenyl ether structures,with compound 4 featuring an uncommon dibenzofuran as the diphenyl ether component.The structural elucidation and determination of absolute stereochemistry were accomplished through spectroscopic analysis and electronic circular dichroism(ECD)calculations.Notably,diphenylemestrin C(3)exhibited moderate cytostatic activity against NB4 cells,with a half maximal inhibitory concentration(IC50)value of 21.99μmol·L-1,and induced apoptosis at higher concentrations.展开更多
基金The National Key Research and Development Program of China(No.2021YFA0910500)the National Natural Science Foundation of China(Nos.U22A20380,82104028,82173706,and 82373755)+1 种基金the Science and Technology Major Project of Hubei Province(No.2021ACA012)the Fundamental Research Funds for the Central Universities,HUST(No.2021JYCXJJ058)。
文摘A chemical investigation of secondary metabolites(SMs)from Aspergillus nidulans resulted in the identification of five novel dioxopiperazine(DKP)-diphenyl ether hybrids,designated as diphenylemestrins A-E(1-5).These compounds 1-5 represent the first known dimers combining DKP and diphenyl ether structures,with compound 4 featuring an uncommon dibenzofuran as the diphenyl ether component.The structural elucidation and determination of absolute stereochemistry were accomplished through spectroscopic analysis and electronic circular dichroism(ECD)calculations.Notably,diphenylemestrin C(3)exhibited moderate cytostatic activity against NB4 cells,with a half maximal inhibitory concentration(IC50)value of 21.99μmol·L-1,and induced apoptosis at higher concentrations.
