The principal stresses will increase or decrease during mining,leading to variations in surrounding rock strength and subsequently an influence on the risk of rockbursts.To address this issue,this study conducted theo...The principal stresses will increase or decrease during mining,leading to variations in surrounding rock strength and subsequently an influence on the risk of rockbursts.To address this issue,this study conducted theoretical analysis,numerical simulation,and field monitoring.A rockburst risk analysis method that integrates dynamic changes in the stress and strength of surrounding rock was proposed and verified in the field.The dynamic changes in maximum(σ_(1))and minimum(σ_(3))principal stresses are represented by the σ_(1) and σ_(3) differentials,respectively.The difference in principal stress differential(DPSD),defined as the difference between σ_(1) and σ_(3),was introduced as a novel indicator for rockburst risk analysis.The findings of this study demonstrate a positive correlation between increases in DPSD and heightened risks of rockbursts,as evidenced by an increase in both the frequency of rockbursts and the occurrence of large-energy microseismic events.Conversely,a decrease in DPSD is associated with a reduction in risk.Specifically,in the W1123 panel of a coal mine susceptible to rockbursts,areas exhibiting higher DPSD values experienced more frequent and severe rockbursts.The DPSD-based analysis aligned well with the observed rockburst occurrences.Subsequent optimization of rockburst prevention measures in areas with elevated DPSD led to a reduction in DPSD.Following these adjustments,the W1123 panel predominantly experienced low-energy microseismic events,with a significant decrease in large-energy microseismic events and no further rockbursts.The DPSD analysis is a valuable tool for evaluating rockburst risk and aiding in prevention,which is of great significance for disaster prevention.展开更多
Inter-industry wage differentials in China, measured in terms of average employment earnings by industry, are significant and have been increasing since 1988. The coefficient of variables measuring inter-industry aver...Inter-industry wage differentials in China, measured in terms of average employment earnings by industry, are significant and have been increasing since 1988. The coefficient of variables measuring inter-industry average earning differentials is apparently on the rise along with the subdivision of industry. A theoretical analysis of the labour market indicates that inter-industry wage differentials are mainly due to human capital variation among the employees of different industries and the likelihood of monopoly rent sharing. An empirical study finds that employee characteristics such as sex, age and education can only explain 60 percent of CVs in the period 2003 to 2005 and the rest may be due to the effect of monopoly rent sharing in certain industries. A residual analysis of wage equation proves that the monopoly industries of technology or knowledge share a small proportion of rents with employment, whereas non-competitive monopoly industries generally garner an abnormal share of rents, as much as half of their above-average earnings for their industries. Such abnormal rents and benefits are mainly the result of low cost natural resources, the use of state-owned assets, the misappropriation of consumer welfare and the seeking of fiscal or social subsidy for cost inflation. So, China should deal with the non-competitive monopoly industries by reforming their monopoly power and primary social distribution mechanism to structure a fair income distribution order.展开更多
Grain mold, associated with many fungi, is the most important disease of sorghum, causing both yield and quality losses. In this study, 23 sorghum differentials used in pathotype characterization of anthracnose and he...Grain mold, associated with many fungi, is the most important disease of sorghum, causing both yield and quality losses. In this study, 23 sorghum differentials used in pathotype characterization of anthracnose and head smut pathogens were evaluated for grain mold resistance under favorable conditions in Isabela, Puerto Rico. Lines BTx643 and IS18760 exhibited the lowest grain mold severity, indicating that these two may possess genes for grain mold resistance. These two lines also recorded the highest germination rates 94.7% and 97.6%, respectively, and their seed weight was among the heaviest. In conclusion, these two lines can be utilized in breeding programs to develop grain mold-resistant hybrid lines.展开更多
Analyzing the effects of heat rejection from condensers of split-type air-conditioning units at lower-floors of MLABs （multi-level apartment buildings）, using field measurements to monitor environmental conditions a...Analyzing the effects of heat rejection from condensers of split-type air-conditioning units at lower-floors of MLABs （multi-level apartment buildings）, using field measurements to monitor environmental conditions and condenser operation, revealed increases in the inlet air temperature at the condensers at the upper floors, which in turn increased the power and energy requirements for these units and decreased their cooling capacities. Results indicated that a decrease of up to 16,000 tons in cooling capacity and an increase of up to 67.2 MW in the national peak load demand might be reached for a 4 ℃ temperature differential for Kuwait conditions. It is recommended that the condensers be placed in the wind pathway to minimize the impact of heat rejection and stack effect and to optimize the operation of split-type air-conditioning units, and that other factors regarding installation setup and location are investigated.展开更多
Defects in kinematic joints can sometimes highly influence the simulation response of the whole multibody system within which these joints are included. For instance, the clearance, the friction, the lubrication and t...Defects in kinematic joints can sometimes highly influence the simulation response of the whole multibody system within which these joints are included. For instance, the clearance, the friction, the lubrication and the flexibility affect the transient behaviour, reduce the component life and produce noise and vibration for classical joints such as prismatics, cylindrics or universal joints.In this work, a new 3D cylindrical joint model which accounts for the clearance, the misalignment and the friction is presented. This formulation has been used to represent the link between the planet gears and the planet carrier in an automotive differential model. C 2013 The Chinese Society of Theoretical and Applied Mechanics. [doi：10.1063/2.1301303]展开更多
Strong and weak limits as well as strong and weak differentials of multi-variable indeterminate forms are discussed based on the thorough exploration of differentiation to solve the strong and weak limits and differen...Strong and weak limits as well as strong and weak differentials of multi-variable indeterminate forms are discussed based on the thorough exploration of differentiation to solve the strong and weak limits and differentials of unitary indeterminate forms. The fruit of this work is going to be reported in three parts. The first part presents the standard analysis on this subject which supplements, systematizes and advances L. Hospital抯 principles on differential calculus by applying special ,general, and limit guaranteeing theories together with K(t) and XhK0 theories. The combination of theoretical analysis and geometric signification makes the derivation intuitional, visual and easy to perceive.展开更多
We prove that the following three properties cannot match each other on a lattice, that differentials of coordinate functions are algebraically dependent on their involutive conjugates, that the involution on a lattic...We prove that the following three properties cannot match each other on a lattice, that differentials of coordinate functions are algebraically dependent on their involutive conjugates, that the involution on a lattice is an antihomomorphism, and that differential calculus has a natural continuum limit.展开更多
Based on the isomorphism between the space of star-shaped sets and the space of continuous positively homogeneous real-valued functions, the star-shaped differential of a directionally differentiable function is defin...Based on the isomorphism between the space of star-shaped sets and the space of continuous positively homogeneous real-valued functions, the star-shaped differential of a directionally differentiable function is defined. Formulas for star-shaped differential of a pointwise maximum and a pointwise minimum of a finite number of directionally differentiable functions, and a composite of two directionaUy differentiable functions are derived. Furthermore, the mean-value theorem for a directionaUy differentiable function is demonstrated.展开更多
The principle of improving the torque amplification factor of E-TVDs with six elements is illustrated in this paper.A velocity diagram is used to study speed and torque relationships.The results reveal that the torque...The principle of improving the torque amplification factor of E-TVDs with six elements is illustrated in this paper.A velocity diagram is used to study speed and torque relationships.The results reveal that the torque amplification factor is the linear combination of the ratio of the differentials of the four elements and the ratio of planetary gear units,and its maximum value is easily more than 10.The E-TVDs with six elements are classified into three types,and there are six different configurations for each type.The torque amplification factor and the speed of interconnection between two planetary gear units are employed to evaluate the different characteristics of each E-TVD with six elements.The feasible configurations of a differential with four elements are also presented by the analysis of velocity level and planarity.This paper helps to further the understanding of the complex interconnection of the planetary gear units in E-TVDs with six elements and the differences of their characteristics.展开更多
By using the unsymmetrical scale instead of the symmetrical scale,the multiplicative intuitionistic fuzzy sets(MIFSs) reflect our intuition more objectively.Each element in a MIFS is expressed by an ordered pair which...By using the unsymmetrical scale instead of the symmetrical scale,the multiplicative intuitionistic fuzzy sets(MIFSs) reflect our intuition more objectively.Each element in a MIFS is expressed by an ordered pair which is called a multiplicative intuitionistic fuzzy number(MIFN)and is based on the unbalanced scale(i.e.,Saaty’s 1-9 scale).In order to describe the derivatives and differentials for multiplicative intuitionistic fuzzy information more comprehensively,in this paper,we firstly propose two new basic operational laws for MIFNs,which are the subtraction law and the division law.Secondly,we describe the change values of MIFNs when considering them as variables,classify these change values based on the basic operational laws for MIFNs,and depict the convergences of sequences of MIFNs by the subtraction and division laws.Finally,we focus on the multiplicative intuitionistic fuzzy functions and derive some basic results related to their continuities,derivatives and differentials,and also give their application in selecting the configuration of a computer.展开更多
In order to better describe the phenomenon of biological invasion,this paper introduces a free boundary model of biological invasion.Firstly,the right free boundary is added to the equation with logistic terms.Secondl...In order to better describe the phenomenon of biological invasion,this paper introduces a free boundary model of biological invasion.Firstly,the right free boundary is added to the equation with logistic terms.Secondly,the existence and uniqueness of local solutions are proved by the Sobolev embedding theorem and the comparison principle.Finally,according to the relevant research data and contents of red fire ants,the diffusion area and nest number of red fire ants were simulated without external disturbance.This paper mainly simulates the early diffusion process of red fire ants.In the early diffusion stage,red fire ants grow slowly and then spread over a large area after reaching a certain number.展开更多
The organotypic retinal explant culture has been established for more than a decade and offers a range of unique advantages compared with in vivo experiments and cell cultures.However,the lack of systematic and contin...The organotypic retinal explant culture has been established for more than a decade and offers a range of unique advantages compared with in vivo experiments and cell cultures.However,the lack of systematic and continuous comparison between in vivo retinal development and the organotypic retinal explant culture makes this model controversial in postnatal retinal development studies.Thus,we aimed to verify the feasibility of using this model for postnatal retinal development studies by comparing it with the in vivo retina.In this study,we showed that postnatal retinal explants undergo normal development,and exhibit a consistent structure and timeline with retinas in vivo.Initially,we used SOX2 and PAX6 immunostaining to identify retinal progenitor cells.We then examined cell proliferation and migration by immunostaining with Ki-67 and doublecortin,respectively.Ki-67-and doublecortin-positive cells decreased in both in vivo and explants during postnatal retinogenesis,and exhibited a high degree of similarity in abundance and distribution between groups.Additionally,we used Ceh-10 homeodomain-containing homolog,glutamate-ammonia ligase(glutamine synthetase),neuronal nuclei,and ionized calcium-binding adapter molecule 1 immunostaining to examine the emergence of bipolar cells,Müller glia,mature neurons,and microglia,respectively.The timing and spatial patterns of the emergence of these cell types were remarkably consistent between in vivo and explant retinas.Our study showed that the organotypic retinal explant culture model had a high degree of consistency with the progression of in vivo early postnatal retina development.The findings confirm the accuracy and credibility of this model and support its use for long-term,systematic,and continuous observation.展开更多
A microgravity environment has been shown to cause ocular damage and affect visual acuity,but the underlying mechanisms remain unclear.Therefore,we established an animal model of weightlessness via tail suspension to ...A microgravity environment has been shown to cause ocular damage and affect visual acuity,but the underlying mechanisms remain unclear.Therefore,we established an animal model of weightlessness via tail suspension to examine the pathological changes and molecular mechanisms of retinal damage under microgravity.After 4 weeks of tail suspension,there were no notable alterations in retinal function and morphology,while after 8 weeks of tail suspension,significant reductions in retinal function were observed,and the outer nuclear layer was thinner,with abundant apoptotic cells.To investigate the mechanism underlying the degenerative changes that occurred in the outer nuclear layer of the retina,proteomics was used to analyze differentially expressed proteins in rat retinas after 8 weeks of tail suspension.The results showed that the expression levels of fibroblast growth factor 2(also known as basic fibroblast growth factor)and glial fibrillary acidic protein,which are closely related to Müller cell activation,were significantly upregulated.In addition,Müller cell regeneration and Müller cell gliosis were observed after 4 and 8 weeks,respectively,of simulated weightlessness.These findings indicate that Müller cells play an important regulatory role in retinal outer nuclear layer degeneration during weightlessness.展开更多
Precisely estimating the state of health(SOH)of lithium-ion batteries is essential for battery management systems(BMS),as it plays a key role in ensuring the safe and reliable operation of battery systems.However,curr...Precisely estimating the state of health(SOH)of lithium-ion batteries is essential for battery management systems(BMS),as it plays a key role in ensuring the safe and reliable operation of battery systems.However,current SOH estimation methods often overlook the valuable temperature information that can effectively characterize battery aging during capacity degradation.Additionally,the Elman neural network,which is commonly employed for SOH estimation,exhibits several drawbacks,including slow training speed,a tendency to become trapped in local minima,and the initialization of weights and thresholds using pseudo-random numbers,leading to unstable model performance.To address these issues,this study addresses the challenge of precise and effective SOH detection by proposing a method for estimating the SOH of lithium-ion batteries based on differential thermal voltammetry(DTV)and an SSA-Elman neural network.Firstly,two health features(HFs)considering temperature factors and battery voltage are extracted fromthe differential thermal voltammetry curves and incremental capacity curves.Next,the Sparrow Search Algorithm(SSA)is employed to optimize the initial weights and thresholds of the Elman neural network,forming the SSA-Elman neural network model.To validate the performance,various neural networks,including the proposed SSA-Elman network,are tested using the Oxford battery aging dataset.The experimental results demonstrate that the method developed in this study achieves superior accuracy and robustness,with a mean absolute error(MAE)of less than 0.9%and a rootmean square error(RMSE)below 1.4%.展开更多
Labor migration is institutionally restricted within China under the hukou system, China registration system. However, what is the pecuniary impact of labor immobility on interregional wage inequality？ To answer this...Labor migration is institutionally restricted within China under the hukou system, China registration system. However, what is the pecuniary impact of labor immobility on interregional wage inequality？ To answer this question, we derive a simple wage gap equation including educational attainment, market potential and provincial border indicators. The regressions based on city and sector-level data show that, other things being equal, the wage dispersions within Chinese provincial borders are significantly less pronounced than those among provinces. Such border effects on spatial wage differentials, which have been shown to pervasively exist in all sectors considered in the present paper, reflect the distortions generated by migration controls. Finally, we show that despite the recent hukou reforms aimed at relaxing the restrictions on population movement, border effects appear to persisted over the period 2003-2005.展开更多
Neural EGFL-like 2(NELL2)is a secreted protein known for its regulatory functions in the nervous and reproductive systems,yet its role in bone biology remains unexplored.In this study,we observed that NELL2 was dimini...Neural EGFL-like 2(NELL2)is a secreted protein known for its regulatory functions in the nervous and reproductive systems,yet its role in bone biology remains unexplored.In this study,we observed that NELL2 was diminished in the bone of aged and ovariectomized(OVX)mice,as well as in the serum of osteopenia and osteoporosis patients.In vitro loss-of-function and gain-offunction studies revealed that NELL2 facilitated osteoblast differentiation and impeded adipocyte differentiation from stromal progenitor cells.In vivo studies further demonstrated that the deletion of NELL2 in preosteoblasts resulted in decreased cancellous bone mass in mice.Mechanistically,NELL2 interacted with the FNI-type domain located at the C-terminus of Fibronectin 1(Fn1).Moreover,we found that NELL2 activated the focal adhesion kinase(FAK)/AKT signaling pathway through Fn1/integrinβ1(ITGB1),leading to the promotion of osteogenesis and the inhibition of adipogenesis.Notably,administration of NELL2-AAV was found to ameliorate bone loss in OVX mice.These findings underscore the significant role of NELL2 in osteoblast differentiation and bone homeostasis,suggesting its potential as a therapeutic target for managing osteoporosis.展开更多
The delicate balance between bone formation by osteoblasts and bone resorption by osteoclasts maintains bone homeostasis.Nuclear receptors(NRs)are now understood to be crucial in bone physiology and pathology.However,...The delicate balance between bone formation by osteoblasts and bone resorption by osteoclasts maintains bone homeostasis.Nuclear receptors(NRs)are now understood to be crucial in bone physiology and pathology.However,the function of the Farnesoid X receptor(FXR),a member of the NR family,in regulating bone homeostasis remains incompletely understood.In this study,in vitro and in vivo models revealed delayed bone development and an osteoporosis phenotype in mice lacking FXR in bone marrow mesenchymal stem cells(BMSCs)and osteoblasts due to impaired osteoblast differentiation.Mechanistically,FXR could stabilize RUNX2 by inhibiting Thoc6-mediated ubiquitination,thereby promoting osteogenic activity in BMSCs.Moreover,activated FXR could directly bind to the Thoc6 promoter,suppressing its expression.The interaction between RUNX2 and Thoc6 was mediated by the Runt domain of RUNX2 and the WD repeat of Thoc6.Additionally,Obeticholic acid(OCA),an orally available FXR agonist,could ameliorate bone loss in an ovariectomy(OVX)-induced osteoporotic mouse model.Taken together,our findings suggest that FXR plays pivotal roles in osteoblast differentiation by regulating RUNX2 stability and that targeting FXR may be a promising therapeutic approach for osteoporosis.展开更多
基金support from the National Natural Science Foundation of China(Grant Nos.52374180 and 52327804).
文摘The principal stresses will increase or decrease during mining,leading to variations in surrounding rock strength and subsequently an influence on the risk of rockbursts.To address this issue,this study conducted theoretical analysis,numerical simulation,and field monitoring.A rockburst risk analysis method that integrates dynamic changes in the stress and strength of surrounding rock was proposed and verified in the field.The dynamic changes in maximum(σ_(1))and minimum(σ_(3))principal stresses are represented by the σ_(1) and σ_(3) differentials,respectively.The difference in principal stress differential(DPSD),defined as the difference between σ_(1) and σ_(3),was introduced as a novel indicator for rockburst risk analysis.The findings of this study demonstrate a positive correlation between increases in DPSD and heightened risks of rockbursts,as evidenced by an increase in both the frequency of rockbursts and the occurrence of large-energy microseismic events.Conversely,a decrease in DPSD is associated with a reduction in risk.Specifically,in the W1123 panel of a coal mine susceptible to rockbursts,areas exhibiting higher DPSD values experienced more frequent and severe rockbursts.The DPSD-based analysis aligned well with the observed rockburst occurrences.Subsequent optimization of rockburst prevention measures in areas with elevated DPSD led to a reduction in DPSD.Following these adjustments,the W1123 panel predominantly experienced low-energy microseismic events,with a significant decrease in large-energy microseismic events and no further rockbursts.The DPSD analysis is a valuable tool for evaluating rockburst risk and aiding in prevention,which is of great significance for disaster prevention.
基金funded by the National Philosophy and Social Science Innovation Centre of Economic ransition and Development of Nanjing University sponsored by the Ministry of Education of China
文摘Inter-industry wage differentials in China, measured in terms of average employment earnings by industry, are significant and have been increasing since 1988. The coefficient of variables measuring inter-industry average earning differentials is apparently on the rise along with the subdivision of industry. A theoretical analysis of the labour market indicates that inter-industry wage differentials are mainly due to human capital variation among the employees of different industries and the likelihood of monopoly rent sharing. An empirical study finds that employee characteristics such as sex, age and education can only explain 60 percent of CVs in the period 2003 to 2005 and the rest may be due to the effect of monopoly rent sharing in certain industries. A residual analysis of wage equation proves that the monopoly industries of technology or knowledge share a small proportion of rents with employment, whereas non-competitive monopoly industries generally garner an abnormal share of rents, as much as half of their above-average earnings for their industries. Such abnormal rents and benefits are mainly the result of low cost natural resources, the use of state-owned assets, the misappropriation of consumer welfare and the seeking of fiscal or social subsidy for cost inflation. So, China should deal with the non-competitive monopoly industries by reforming their monopoly power and primary social distribution mechanism to structure a fair income distribution order.
文摘Grain mold, associated with many fungi, is the most important disease of sorghum, causing both yield and quality losses. In this study, 23 sorghum differentials used in pathotype characterization of anthracnose and head smut pathogens were evaluated for grain mold resistance under favorable conditions in Isabela, Puerto Rico. Lines BTx643 and IS18760 exhibited the lowest grain mold severity, indicating that these two may possess genes for grain mold resistance. These two lines also recorded the highest germination rates 94.7% and 97.6%, respectively, and their seed weight was among the heaviest. In conclusion, these two lines can be utilized in breeding programs to develop grain mold-resistant hybrid lines.
文摘Analyzing the effects of heat rejection from condensers of split-type air-conditioning units at lower-floors of MLABs （multi-level apartment buildings）, using field measurements to monitor environmental conditions and condenser operation, revealed increases in the inlet air temperature at the condensers at the upper floors, which in turn increased the power and energy requirements for these units and decreased their cooling capacities. Results indicated that a decrease of up to 16,000 tons in cooling capacity and an increase of up to 67.2 MW in the national peak load demand might be reached for a 4 ℃ temperature differential for Kuwait conditions. It is recommended that the condensers be placed in the wind pathway to minimize the impact of heat rejection and stack effect and to optimize the operation of split-type air-conditioning units, and that other factors regarding installation setup and location are investigated.
基金the Belgian National Fund for Scientific research (FRIA) for its financial support
文摘Defects in kinematic joints can sometimes highly influence the simulation response of the whole multibody system within which these joints are included. For instance, the clearance, the friction, the lubrication and the flexibility affect the transient behaviour, reduce the component life and produce noise and vibration for classical joints such as prismatics, cylindrics or universal joints.In this work, a new 3D cylindrical joint model which accounts for the clearance, the misalignment and the friction is presented. This formulation has been used to represent the link between the planet gears and the planet carrier in an automotive differential model. C 2013 The Chinese Society of Theoretical and Applied Mechanics. [doi：10.1063/2.1301303]
文摘Strong and weak limits as well as strong and weak differentials of multi-variable indeterminate forms are discussed based on the thorough exploration of differentiation to solve the strong and weak limits and differentials of unitary indeterminate forms. The fruit of this work is going to be reported in three parts. The first part presents the standard analysis on this subject which supplements, systematizes and advances L. Hospital抯 principles on differential calculus by applying special ,general, and limit guaranteeing theories together with K(t) and XhK0 theories. The combination of theoretical analysis and geometric signification makes the derivation intuitional, visual and easy to perceive.
文摘We prove that the following three properties cannot match each other on a lattice, that differentials of coordinate functions are algebraically dependent on their involutive conjugates, that the involution on a lattice is an antihomomorphism, and that differential calculus has a natural continuum limit.
文摘Based on the isomorphism between the space of star-shaped sets and the space of continuous positively homogeneous real-valued functions, the star-shaped differential of a directionally differentiable function is defined. Formulas for star-shaped differential of a pointwise maximum and a pointwise minimum of a finite number of directionally differentiable functions, and a composite of two directionaUy differentiable functions are derived. Furthermore, the mean-value theorem for a directionaUy differentiable function is demonstrated.
基金Natural Science Foundation of Jiangsu Province(BK20160223)。
文摘The principle of improving the torque amplification factor of E-TVDs with six elements is illustrated in this paper.A velocity diagram is used to study speed and torque relationships.The results reveal that the torque amplification factor is the linear combination of the ratio of the differentials of the four elements and the ratio of planetary gear units,and its maximum value is easily more than 10.The E-TVDs with six elements are classified into three types,and there are six different configurations for each type.The torque amplification factor and the speed of interconnection between two planetary gear units are employed to evaluate the different characteristics of each E-TVD with six elements.The feasible configurations of a differential with four elements are also presented by the analysis of velocity level and planarity.This paper helps to further the understanding of the complex interconnection of the planetary gear units in E-TVDs with six elements and the differences of their characteristics.
基金supported in part by the National Natural Science Foundation of China(71571123,71771155)
文摘By using the unsymmetrical scale instead of the symmetrical scale,the multiplicative intuitionistic fuzzy sets(MIFSs) reflect our intuition more objectively.Each element in a MIFS is expressed by an ordered pair which is called a multiplicative intuitionistic fuzzy number(MIFN)and is based on the unbalanced scale(i.e.,Saaty’s 1-9 scale).In order to describe the derivatives and differentials for multiplicative intuitionistic fuzzy information more comprehensively,in this paper,we firstly propose two new basic operational laws for MIFNs,which are the subtraction law and the division law.Secondly,we describe the change values of MIFNs when considering them as variables,classify these change values based on the basic operational laws for MIFNs,and depict the convergences of sequences of MIFNs by the subtraction and division laws.Finally,we focus on the multiplicative intuitionistic fuzzy functions and derive some basic results related to their continuities,derivatives and differentials,and also give their application in selecting the configuration of a computer.
基金Supported by National Natural Science Foundation of China(12101482)Postdoctoral Science Foundation of China(2022M722604)+2 种基金General Project of Science and Technology of Shaanxi Province(2023-YBSF-372)The Natural Science Foundation of Shaan Xi Province(2023-JCQN-0016)Shannxi Mathmatical Basic Science Research Project(23JSQ042)。
文摘In order to better describe the phenomenon of biological invasion,this paper introduces a free boundary model of biological invasion.Firstly,the right free boundary is added to the equation with logistic terms.Secondly,the existence and uniqueness of local solutions are proved by the Sobolev embedding theorem and the comparison principle.Finally,according to the relevant research data and contents of red fire ants,the diffusion area and nest number of red fire ants were simulated without external disturbance.This paper mainly simulates the early diffusion process of red fire ants.In the early diffusion stage,red fire ants grow slowly and then spread over a large area after reaching a certain number.
基金supported by the National Natural Science Foundation of China,Nos.81901156(to ZZ),82271200(to ZZ),82171308(to XC)the Fundamental Research Funds for the Central Universities,No.xzy012022035(to ZZ)+1 种基金the Natural Science Foundation of Shaanxi Province,Nos.2021JM-261(to QK),2023-YBSF-303(to ZZ)Traditional Chinese Medicine Project of Shaanxi Province,No.2019-ZZ-JC047(to QK)。
文摘The organotypic retinal explant culture has been established for more than a decade and offers a range of unique advantages compared with in vivo experiments and cell cultures.However,the lack of systematic and continuous comparison between in vivo retinal development and the organotypic retinal explant culture makes this model controversial in postnatal retinal development studies.Thus,we aimed to verify the feasibility of using this model for postnatal retinal development studies by comparing it with the in vivo retina.In this study,we showed that postnatal retinal explants undergo normal development,and exhibit a consistent structure and timeline with retinas in vivo.Initially,we used SOX2 and PAX6 immunostaining to identify retinal progenitor cells.We then examined cell proliferation and migration by immunostaining with Ki-67 and doublecortin,respectively.Ki-67-and doublecortin-positive cells decreased in both in vivo and explants during postnatal retinogenesis,and exhibited a high degree of similarity in abundance and distribution between groups.Additionally,we used Ceh-10 homeodomain-containing homolog,glutamate-ammonia ligase(glutamine synthetase),neuronal nuclei,and ionized calcium-binding adapter molecule 1 immunostaining to examine the emergence of bipolar cells,Müller glia,mature neurons,and microglia,respectively.The timing and spatial patterns of the emergence of these cell types were remarkably consistent between in vivo and explant retinas.Our study showed that the organotypic retinal explant culture model had a high degree of consistency with the progression of in vivo early postnatal retina development.The findings confirm the accuracy and credibility of this model and support its use for long-term,systematic,and continuous observation.
基金supported by the Army Laboratory Animal Foundation of China,No.SYDW[2020]22(to TC)the Shaanxi Provincial Key R&D Plan General Project of China,No.2022SF-236(to YM)the National Natural Science Foundation of China,No.82202070(to TC)。
文摘A microgravity environment has been shown to cause ocular damage and affect visual acuity,but the underlying mechanisms remain unclear.Therefore,we established an animal model of weightlessness via tail suspension to examine the pathological changes and molecular mechanisms of retinal damage under microgravity.After 4 weeks of tail suspension,there were no notable alterations in retinal function and morphology,while after 8 weeks of tail suspension,significant reductions in retinal function were observed,and the outer nuclear layer was thinner,with abundant apoptotic cells.To investigate the mechanism underlying the degenerative changes that occurred in the outer nuclear layer of the retina,proteomics was used to analyze differentially expressed proteins in rat retinas after 8 weeks of tail suspension.The results showed that the expression levels of fibroblast growth factor 2(also known as basic fibroblast growth factor)and glial fibrillary acidic protein,which are closely related to Müller cell activation,were significantly upregulated.In addition,Müller cell regeneration and Müller cell gliosis were observed after 4 and 8 weeks,respectively,of simulated weightlessness.These findings indicate that Müller cells play an important regulatory role in retinal outer nuclear layer degeneration during weightlessness.
基金supported by the National Natural Science Foundation of China(NSFC)under Grant(No.51677058).
文摘Precisely estimating the state of health(SOH)of lithium-ion batteries is essential for battery management systems(BMS),as it plays a key role in ensuring the safe and reliable operation of battery systems.However,current SOH estimation methods often overlook the valuable temperature information that can effectively characterize battery aging during capacity degradation.Additionally,the Elman neural network,which is commonly employed for SOH estimation,exhibits several drawbacks,including slow training speed,a tendency to become trapped in local minima,and the initialization of weights and thresholds using pseudo-random numbers,leading to unstable model performance.To address these issues,this study addresses the challenge of precise and effective SOH detection by proposing a method for estimating the SOH of lithium-ion batteries based on differential thermal voltammetry(DTV)and an SSA-Elman neural network.Firstly,two health features(HFs)considering temperature factors and battery voltage are extracted fromthe differential thermal voltammetry curves and incremental capacity curves.Next,the Sparrow Search Algorithm(SSA)is employed to optimize the initial weights and thresholds of the Elman neural network,forming the SSA-Elman neural network model.To validate the performance,various neural networks,including the proposed SSA-Elman network,are tested using the Oxford battery aging dataset.The experimental results demonstrate that the method developed in this study achieves superior accuracy and robustness,with a mean absolute error(MAE)of less than 0.9%and a rootmean square error(RMSE)below 1.4%.
文摘Labor migration is institutionally restricted within China under the hukou system, China registration system. However, what is the pecuniary impact of labor immobility on interregional wage inequality？ To answer this question, we derive a simple wage gap equation including educational attainment, market potential and provincial border indicators. The regressions based on city and sector-level data show that, other things being equal, the wage dispersions within Chinese provincial borders are significantly less pronounced than those among provinces. Such border effects on spatial wage differentials, which have been shown to pervasively exist in all sectors considered in the present paper, reflect the distortions generated by migration controls. Finally, we show that despite the recent hukou reforms aimed at relaxing the restrictions on population movement, border effects appear to persisted over the period 2003-2005.
基金supported by grants from National Natural Science Foundation of China(82272444,81972031,81972033)China Postdoctoral Science Foundation(2022M722382)Tianjin Key Medical Discipline(Specialty)Construction Project(TJYXZDXK-032A)。
文摘Neural EGFL-like 2(NELL2)is a secreted protein known for its regulatory functions in the nervous and reproductive systems,yet its role in bone biology remains unexplored.In this study,we observed that NELL2 was diminished in the bone of aged and ovariectomized(OVX)mice,as well as in the serum of osteopenia and osteoporosis patients.In vitro loss-of-function and gain-offunction studies revealed that NELL2 facilitated osteoblast differentiation and impeded adipocyte differentiation from stromal progenitor cells.In vivo studies further demonstrated that the deletion of NELL2 in preosteoblasts resulted in decreased cancellous bone mass in mice.Mechanistically,NELL2 interacted with the FNI-type domain located at the C-terminus of Fibronectin 1(Fn1).Moreover,we found that NELL2 activated the focal adhesion kinase(FAK)/AKT signaling pathway through Fn1/integrinβ1(ITGB1),leading to the promotion of osteogenesis and the inhibition of adipogenesis.Notably,administration of NELL2-AAV was found to ameliorate bone loss in OVX mice.These findings underscore the significant role of NELL2 in osteoblast differentiation and bone homeostasis,suggesting its potential as a therapeutic target for managing osteoporosis.
基金supported by National Natural Science Foundation of China(grant numbers 82072523 to Zhiyong Hou)Postdoctoral program of Clinical medicine of Hebei Medical University(grant numbers PD2023012 to Sujuan Xu)+2 种基金Excellent postdoctoral research funding project of Hebei Province(grant numbers B2023005011 to Sujuan Xu)The 16th special grant of China Postdoctoral Science Foundation(grant numbers 2023T160182 to Sujuan Xu)Natural Science Foundation of Hebei Province,China(grant numbers H2023206230 to Yingchao Yin,H2024206186 to Sujuan Xu).
文摘The delicate balance between bone formation by osteoblasts and bone resorption by osteoclasts maintains bone homeostasis.Nuclear receptors(NRs)are now understood to be crucial in bone physiology and pathology.However,the function of the Farnesoid X receptor(FXR),a member of the NR family,in regulating bone homeostasis remains incompletely understood.In this study,in vitro and in vivo models revealed delayed bone development and an osteoporosis phenotype in mice lacking FXR in bone marrow mesenchymal stem cells(BMSCs)and osteoblasts due to impaired osteoblast differentiation.Mechanistically,FXR could stabilize RUNX2 by inhibiting Thoc6-mediated ubiquitination,thereby promoting osteogenic activity in BMSCs.Moreover,activated FXR could directly bind to the Thoc6 promoter,suppressing its expression.The interaction between RUNX2 and Thoc6 was mediated by the Runt domain of RUNX2 and the WD repeat of Thoc6.Additionally,Obeticholic acid(OCA),an orally available FXR agonist,could ameliorate bone loss in an ovariectomy(OVX)-induced osteoporotic mouse model.Taken together,our findings suggest that FXR plays pivotal roles in osteoblast differentiation by regulating RUNX2 stability and that targeting FXR may be a promising therapeutic approach for osteoporosis.
