Dasycarine, a new quinoline alkaloid along with five known compounds, dictamine, dihydroobacunone, obacunone, fraxinellone and beta-sitosterol, were isolated from Dictamnus dasycarpus. The structure of dasycarine was ...Dasycarine, a new quinoline alkaloid along with five known compounds, dictamine, dihydroobacunone, obacunone, fraxinellone and beta-sitosterol, were isolated from Dictamnus dasycarpus. The structure of dasycarine was identified as 4, 5, 8- trimethoxyl -3- (3- methyl -2-butenyl)- 2- quinone by 1D and 2D NMR techniques.展开更多
The present study carried out a phytochemical investigation on the root barks of Dictamnus dasycarpus Turcz, leading to the isolation and characterization of two new aromatic ring butyrolactone derivatives, dasycarpus...The present study carried out a phytochemical investigation on the root barks of Dictamnus dasycarpus Turcz, leading to the isolation and characterization of two new aromatic ring butyrolactone derivatives, dasycarpusphenol acid A(1) and dasycarpusphenol acid B(2). Their structures were elucidated by using spectroscopic techniques and HR-FAB-MS. Compounds 1 and 2 exhibited antioxidant activity, with their IC_(50) values being 28.95 and 41.76 mg·mL^(-1),respectively.展开更多
AIM： To investigate the quinoline alkaloids from the roots ofDictamnus angustifolius G.Don ex Sweet （Rutaceae）. METHOD： The quinoline alkaloids were isolated by various column chromatographic methods and their str...AIM： To investigate the quinoline alkaloids from the roots ofDictamnus angustifolius G.Don ex Sweet （Rutaceae）. METHOD： The quinoline alkaloids were isolated by various column chromatographic methods and their structures were eluci- dated on the basis of spectral analysis. RESULTS： A new quinoline alkaloid, 5-methoxylrobustine （1）, along with five known quinoline alkaloids were obtained, and their structures were identified as dictamnine （2）, robustine （3）, isopteleine （4）, 7-fagarine （5）, and skimmianine （6）. Cytotoxicity testing of these alkaloids showed that all of them had weak cytotoxic activities against human breast cancer cells （MCF7）. CONCLUSION： Compound 1 is a new quinoline alkaloid. Alkaloid 3 showed stronger anti-proliferation effect than the other al- kaloids.展开更多
Two novel sesquiterpene diglycosides named dictamnosides F 1 and G 2 were isolated from methanol extract of the root bark of Dictamnus dasycarpus. Their structures were determined on the basis of spectroscopic and che...Two novel sesquiterpene diglycosides named dictamnosides F 1 and G 2 were isolated from methanol extract of the root bark of Dictamnus dasycarpus. Their structures were determined on the basis of spectroscopic and chemical analysis.展开更多
Aim To gain the active compounds fromDictamnus dasycarpus.Method The solvent partition,preparative TLC,spectral analysis and bioassay are used to gain the active compounds.Results Fraxinellone is a main biological act...Aim To gain the active compounds fromDictamnus dasycarpus.Method The solvent partition,preparative TLC,spectral analysis and bioassay are used to gain the active compounds.Results Fraxinellone is a main biological actives substance fromD.dasycarpus was gained.Conclusion Its antifeeding rate and death rate of 72hat 0.21%(mass percent) against Mythimna setarata were 90.4%and 95.2%,respectively.展开更多
文摘Dasycarine, a new quinoline alkaloid along with five known compounds, dictamine, dihydroobacunone, obacunone, fraxinellone and beta-sitosterol, were isolated from Dictamnus dasycarpus. The structure of dasycarine was identified as 4, 5, 8- trimethoxyl -3- (3- methyl -2-butenyl)- 2- quinone by 1D and 2D NMR techniques.
基金supported by the Natural Science Foundation of Heilongjiang(No.D201207)
文摘The present study carried out a phytochemical investigation on the root barks of Dictamnus dasycarpus Turcz, leading to the isolation and characterization of two new aromatic ring butyrolactone derivatives, dasycarpusphenol acid A(1) and dasycarpusphenol acid B(2). Their structures were elucidated by using spectroscopic techniques and HR-FAB-MS. Compounds 1 and 2 exhibited antioxidant activity, with their IC_(50) values being 28.95 and 41.76 mg·mL^(-1),respectively.
基金supported by the National New Drug Innovation Major Project of China(No.2011ZX09307-002-02)
文摘AIM： To investigate the quinoline alkaloids from the roots ofDictamnus angustifolius G.Don ex Sweet （Rutaceae）. METHOD： The quinoline alkaloids were isolated by various column chromatographic methods and their structures were eluci- dated on the basis of spectral analysis. RESULTS： A new quinoline alkaloid, 5-methoxylrobustine （1）, along with five known quinoline alkaloids were obtained, and their structures were identified as dictamnine （2）, robustine （3）, isopteleine （4）, 7-fagarine （5）, and skimmianine （6）. Cytotoxicity testing of these alkaloids showed that all of them had weak cytotoxic activities against human breast cancer cells （MCF7）. CONCLUSION： Compound 1 is a new quinoline alkaloid. Alkaloid 3 showed stronger anti-proliferation effect than the other al- kaloids.
文摘Two novel sesquiterpene diglycosides named dictamnosides F 1 and G 2 were isolated from methanol extract of the root bark of Dictamnus dasycarpus. Their structures were determined on the basis of spectroscopic and chemical analysis.
文摘Aim To gain the active compounds fromDictamnus dasycarpus.Method The solvent partition,preparative TLC,spectral analysis and bioassay are used to gain the active compounds.Results Fraxinellone is a main biological actives substance fromD.dasycarpus was gained.Conclusion Its antifeeding rate and death rate of 72hat 0.21%(mass percent) against Mythimna setarata were 90.4%and 95.2%,respectively.
