Introduction: Intestinal parasitism has been a challenge to overcome for the Mexican deworming campaign and this study determined the prevalence of these infections in schoolchildren treated with albendazole in Northw...Introduction: Intestinal parasitism has been a challenge to overcome for the Mexican deworming campaign and this study determined the prevalence of these infections in schoolchildren treated with albendazole in Northwestern Mexico. Methods: Study sites in marginal conditions, with gastrointestinal infections and albendazole intervention were selected. The Faust and Kato Katz techniques were used to identify the parasites spp. and the NCSS software was used for statistical analysis. Results: A total of 450, 389 and 364 schoolchildren participated in 2005, 2006, and 2007 respectively during this study. The mean age was 7.9 (±1.3). The estimated prevalences were of 42%, 30% and 37% for protozoa infections, and 11%, 12% and 11% for helminth infections in 2005, 2006 and 2007 respectively. Conclusion: The education strategies should be integrated into the Mexican deworming campaign.展开更多
Zoonotic hookworm infections remain a significant public health problem,causing nearly 500 million cases globally and approximately four million disability-adjusted life years lost annually.More than one-fifth of thes...Zoonotic hookworm infections remain a significant public health problem,causing nearly 500 million cases globally and approximately four million disability-adjusted life years lost annually.More than one-fifth of these cases are attributed to Ancylostoma ceylanicum,an emerging zoonotic health issue in the Asia-Pacific region.This review presents key research gaps regarding the epidemiology,diagnosis,control,prevention and elimination of A.ceylanicum and other canine zoonotic hookworms as neglected health threats.A.ceylanicum is the second most prevalent human hookworm in the region;it is the most common hookworm among dogs and cats-reservoirs of zoonotic infections.Previous population genetic and phylogenetic analyses revealed that A.ceylanicum has three possible transmission dynamics:zoonotic,animal-only,and human-only pathways.The actual burden of zoonotic ancylostomiasis in most endemic countries remains unknown due to the use of parasitological techniques(e.g.,Kato-Katz thick smear and floatation techniques)that have reduced diagnostic performance and do not allow accurate species identification in helminth surveys.The emergence of benzimidazole resistance in soil-transmitted helminths(STHs),including hookworms,is a concern due to the protracted implementation of mass drug administration(MDA).Resistance is conferred by single nucleotide polymorphisms(SNPs)that occur in theβ-tubulin isotype 1 gene.These mutations have been reported in drug-resistant A.caninum but have not been found in A.ceylanicum in the field.A.ceylanicum remains understudied in the Asia-Pacific region.The zoonotic nature of the parasite warrants investigation of its occurrence in human and animal reservoir hosts to understand the dynamics of zoonotic transmission in different endemic foci.The detection of benzimidazole resistance-associated SNPs in zoonotic hookworms from Asia-Pacific countries has yet to be thoroughly explored.Considering the high level of hookworm endemicity in the region,the circulation of resistant isolates between humans and animals potentially presents a significant One Health threat that can undermine current MDA and proposed animal deworming-based control efforts.展开更多
文摘Introduction: Intestinal parasitism has been a challenge to overcome for the Mexican deworming campaign and this study determined the prevalence of these infections in schoolchildren treated with albendazole in Northwestern Mexico. Methods: Study sites in marginal conditions, with gastrointestinal infections and albendazole intervention were selected. The Faust and Kato Katz techniques were used to identify the parasites spp. and the NCSS software was used for statistical analysis. Results: A total of 450, 389 and 364 schoolchildren participated in 2005, 2006, and 2007 respectively during this study. The mean age was 7.9 (±1.3). The estimated prevalences were of 42%, 30% and 37% for protozoa infections, and 11%, 12% and 11% for helminth infections in 2005, 2006 and 2007 respectively. Conclusion: The education strategies should be integrated into the Mexican deworming campaign.
基金supported by a Postgraduate Study Support Grant from the Faculty of Medicine,Khon Kaen University.
文摘Zoonotic hookworm infections remain a significant public health problem,causing nearly 500 million cases globally and approximately four million disability-adjusted life years lost annually.More than one-fifth of these cases are attributed to Ancylostoma ceylanicum,an emerging zoonotic health issue in the Asia-Pacific region.This review presents key research gaps regarding the epidemiology,diagnosis,control,prevention and elimination of A.ceylanicum and other canine zoonotic hookworms as neglected health threats.A.ceylanicum is the second most prevalent human hookworm in the region;it is the most common hookworm among dogs and cats-reservoirs of zoonotic infections.Previous population genetic and phylogenetic analyses revealed that A.ceylanicum has three possible transmission dynamics:zoonotic,animal-only,and human-only pathways.The actual burden of zoonotic ancylostomiasis in most endemic countries remains unknown due to the use of parasitological techniques(e.g.,Kato-Katz thick smear and floatation techniques)that have reduced diagnostic performance and do not allow accurate species identification in helminth surveys.The emergence of benzimidazole resistance in soil-transmitted helminths(STHs),including hookworms,is a concern due to the protracted implementation of mass drug administration(MDA).Resistance is conferred by single nucleotide polymorphisms(SNPs)that occur in theβ-tubulin isotype 1 gene.These mutations have been reported in drug-resistant A.caninum but have not been found in A.ceylanicum in the field.A.ceylanicum remains understudied in the Asia-Pacific region.The zoonotic nature of the parasite warrants investigation of its occurrence in human and animal reservoir hosts to understand the dynamics of zoonotic transmission in different endemic foci.The detection of benzimidazole resistance-associated SNPs in zoonotic hookworms from Asia-Pacific countries has yet to be thoroughly explored.Considering the high level of hookworm endemicity in the region,the circulation of resistant isolates between humans and animals potentially presents a significant One Health threat that can undermine current MDA and proposed animal deworming-based control efforts.
