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Fetal programming of obesity and type 2 diabetes 被引量:1
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作者 Sumudu Nimali Seneviratne Shaman Rajindrajith 《World Journal of Diabetes》 SCIE 2022年第7期482-497,共16页
The prevalence of obesity and type 2 diabetes mellitus has increased rapidly over the past few decades,and prevention efforts have not been successful.Fetal programming involves the earliest stage of obesity developme... The prevalence of obesity and type 2 diabetes mellitus has increased rapidly over the past few decades,and prevention efforts have not been successful.Fetal programming involves the earliest stage of obesity development,and provides a novel concept to complement other strategies for lifelong prevention of obesity and type 2 diabetes mellitus.The World Health Organization now advocates a life-course approach to prevent/control obesity,starting with pre-conceptional and antenatal maternal health.Maternal overnutrition,gestational diabetes mellitus and excessive gestational weight gain lead to fetal overgrowth,and“programs”the offspring with an increased risk of obesity and type 2 diabetes mellitus in childhood and adulthood.This review summarizes current data on fetal programming of obesity and type 2 diabetes mellitus including potential causative factors,mechanisms and interventions to reduce its impact. 展开更多
关键词 developmental programming Metabolic syndrome Intergenerational obesity cycle Insulin resistance In utero environment
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Need for education of psychiatric evaluation of offenders with mental disorders:A questionnaire survey for Japanese designated psychiatrists
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作者 Akihiro Shiina Tomihisa Niitsu +1 位作者 Masaomi Iyo Chiyo Fujii 《World Journal of Psychiatry》 SCIE 2024年第5期726-734,共9页
BACKGROUND The management of offenders with mental disorders has been a significant concern in forensic psychiatry.In Japan,the introduction of the Medical Treatment and Supervision Act in 2005 addressed the issue.How... BACKGROUND The management of offenders with mental disorders has been a significant concern in forensic psychiatry.In Japan,the introduction of the Medical Treatment and Supervision Act in 2005 addressed the issue.However,numerous psychiatric patients at risk of violence still find themselves subject to the administrative involuntary hospitalization(AIH)scheme,which lacks clarity and updated standards.AIM To explore current as well as optimized learning strategies for risk assessment in AIH decision making.METHODS We conducted a questionnaire survey among designated psychiatrists to explore their experiences and expectations regarding training methods for psychiatric assessments of offenders with mental disorders.RESULTS The findings of this study’s survey suggest a prevalent reliance on traditional learning approaches such as oral education and on-the-job training.CONCLUSION This underscores the pressing need for structured training protocols in AIH consultations.Moreover,feedback derived from inpatient treatment experiences is identified as a crucial element for enhancing risk assessment skills. 展开更多
关键词 Forensic psychiatry Administrative involuntary hospitalization Psychiatric assessment Risk assessment Mental disorders Training protocols Clinical practice Structured learning Feedback mechanisms Program development
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Analysis of Citizen Participation in Urban Planning of Comala,Colima,Mexico-A Secondary Publication
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作者 Amallinaly GCárdenas Aguilar Peter Chung Alonso +2 位作者 Alicia Cuevas Muñiz Dora Correa Fuentes Ignacio Barajas Avalos 《Journal of World Architecture》 2024年第1期63-75,共13页
The objective of this study was to determine the degree of citizen participation in urban planning processes in the municipality of Comala,Colima,Mexico to have a broader vision of the citizens and the environment in ... The objective of this study was to determine the degree of citizen participation in urban planning processes in the municipality of Comala,Colima,Mexico to have a broader vision of the citizens and the environment in which they live.An instrument was designed specifically to perform this study and the instrument was validated by calculating Cronbach’s Alpha.The results showed that citizens were highly involved in issues concerning their urban environment,and the main problems of the public spaces were also identified. 展开更多
关键词 Citizen participation PLANNING Urban development program
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Developmental toxicity and programming alterations of multiple organs in offspring induced by medication during pregnancy 被引量:4
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作者 Zhengjie Lu Yu Guo +5 位作者 Dan Xu Hao Xiao Yongguo Dai Kexin Liu Liaobin Chen Hui Wang 《Acta Pharmaceutica Sinica B》 SCIE CAS CSCD 2023年第2期460-477,共18页
Medication during pregnancy is widespread,but there are few reports on its fetal safety.Recent studies suggest that medication during pregnancy can affect fetal morphological and functional development through multipl... Medication during pregnancy is widespread,but there are few reports on its fetal safety.Recent studies suggest that medication during pregnancy can affect fetal morphological and functional development through multiple pathways,multiple organs,and multiple targets.Its mechanisms involve direct ways such as oxidative stress,epigenetic modification,and metabolic activation,and it may also be indirectly caused by placental dysfunction.Further studies have found that medication during pregnancy may also indirectly lead to multi-organ developmental programming,functional homeostasis changes,and susceptibility to related diseases in offspring by inducing fetal intrauterine exposure to too high or too low levels of maternal-derived glucocorticoids.The organ developmental toxicity and programming alterations caused by medication during pregnancy may also have gender differences and multi-generational genetic effects mediated by abnormal epigenetic modification.Combined with the latest research results of our laboratory,this paper reviews the latest research progress on the developmental toxicity and functional programming alterations of multiple organs in offspring induced by medication during pregnancy,which can provide a theoretical and experimental basis for rational medication during pregnancy and effective prevention and treatment of drug-related multiple fetal-originated diseases. 展开更多
关键词 MEDICATION PREGNANCY Multiple organs developmental toxicity developmental programming Maternal-derived glucocorticoids Gender differences Multi-generational genetic effects
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Epigenetic origins of metabolic disease:The impact of the maternal condition to the offspring epigenome and later health consequences
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作者 Rhianna C.Laker Mary E.Wlodek +1 位作者 Jessic J.Connelly Zhen Yan 《Food Science and Human Wellness》 SCIE 2013年第1期1-11,共11页
It has long been established that an adverse maternal condition impacts on the developing fetus and predisposes the offspring to develop metabolic and cardiovascular disease in later life.However,the underlying mechan... It has long been established that an adverse maternal condition impacts on the developing fetus and predisposes the offspring to develop metabolic and cardiovascular disease in later life.However,the underlying mechanisms that are initiated during development and contribute to the disease predisposition are understudied.Recently,epigenetic reprogramming in early life has emerged as a promising candidate that could cause altered DNA transcription and gene expression into adulthood and contribute to disease susceptibility.This review will focus on the impact of maternal high fat diet to the offspring in early life and the adult health consequences.We will then discuss the current literature supporting a role for epigenetic modification,such as DNA methylation and histone modifications,as a key mechanism underlying developmental programming.©2013 Beijing Academy of Food Sciences.Production and hosting by Elsevier B.V.All rights reserved. 展开更多
关键词 EPIGENETICS developmental programming Metabolic disease Maternal high-fat diet DNA methylation Histone modifications
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Radon bearing water protection in underground uranium mining--A case study 被引量:4
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作者 Yun Xiaoyou Tang Baoyao +2 位作者 Greg Murdock Brian McGill Brian Mattie 《International Journal of Mining Science and Technology》 SCIE EI CSCD 2017年第4期599-603,共5页
High pressure, radon bearing water has been identified as one of the most critical challenges in mining the high-grade uranium deposit at the Mc Arthur River Operation, Cameco Corporation. The ore deposits are located... High pressure, radon bearing water has been identified as one of the most critical challenges in mining the high-grade uranium deposit at the Mc Arthur River Operation, Cameco Corporation. The ore deposits are located between 490 and 640 m below the surface and surrounded by water bearing Athabasca sandstone, a graphitic P2 fault zone, and highly altered ground. This paper introduces the inflow risk management program at Mc Arthur River Operation, which includes various hydrogeological challenges and the corresponding strategies applied, such as risk-based probe and grout programs(geological, hydrogeological, and geotechnical), ground freezing programs, and comprehensive ground control programs. These programs have been developed, tested, and proven successful over years of mining practices. Working with this world class deposit of high risk and low tolerance, it is believed that these experiences might be beneficial to other mining operations with similar hydrogeological characteristics. 展开更多
关键词 Inflow risk management Geotechnical and development probe and grout programs Dewatering infrastructure Ground freezing Ground control
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Curriculum Innovation in Language Teacher Education:Reflections on the PGDELT Program’s Contributions to EFL Teachers’Continuing Professional Development 被引量:3
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作者 Lawrence Jun ZHANG 《Chinese Journal of Applied Linguistics》 2021年第4期435-450,589,共17页
Initial teacher preparation and teachers’ continuing professional development are two significant pillars of the teacher education enterprise. The former encompasses a wide range of teachereducation initiatives at th... Initial teacher preparation and teachers’ continuing professional development are two significant pillars of the teacher education enterprise. The former encompasses a wide range of teachereducation initiatives at the levels of diploma, bachelor’s degree, postgraduate diploma, and even master’s degree for teacher licensure purposes. These are widely documented in the literature.What is important is how teacher professional development contributes to bolstering the teachereducator force, which is relatively insufficiently documented due to the very fact that different educational systems have somewhat different expectations of such programs in relation to the ideologies and theories underpinning the teacher professional development program design and curriculum offering. Taking stock of a postgraduate diploma program in English language teaching(PGDELT) for teachers’ continuing professional development with a 31-year history housed at a premier teacher education institution in Singapore, which has successfully graduated over 1, 000 English language teachers for colleges and universities in China, I intend to highlight some of its key features, as a former student and then a lecturer on the program, in order to draw implications for sustainable growth of language teacher education programs, especially those whose main purposes are to prepare teachers of English as a second or foreign language(ESL/EFL) and provide continuing professional development opportunities for such inservice teachers. 展开更多
关键词 program development curriculum innovation professional development teacher education English as a second/foreign language China
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Temperature stress analysis for bi-modulus beam placed on Winkler foundation 被引量:1
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作者 Jinling GAO Wenjuan YAO Jiankang LIU 《Applied Mathematics and Mechanics(English Edition)》 SCIE EI CSCD 2017年第7期921-934,共14页
The materials with different moduli in tension and compression are called bi-modulus materials. Graphene is such a kind of materials with the highest strength and the thinnest thickness. In this paper, the mechanical ... The materials with different moduli in tension and compression are called bi-modulus materials. Graphene is such a kind of materials with the highest strength and the thinnest thickness. In this paper, the mechanical response of the bi-modulus beam subjected to the temperature effect and placed on the Winkler foundation is studied. The differential equations about the neutral axis position and undetermined parameters of the normal strain of the bi-modulus foundation beam are established. Then, the analytical expressions of the normal stress, bending moment, and displacement of the foundation beam are derived. Simultaneously, a calculation procedure based on the finite element method (FEM) is developed to obtain the temperature stress of the bi-modulus struc- tures. It is shown that the obtained bi-modulus solutions can recover the classical modulus solution, and the results obtained by the analytical expressions, the present FEM proce- dure, and the traditional FEM software are consistent, which verifies the accuracy and reliability of the present analytical model and procedure. Finally, the difference between the bi-modulus results and the classical same modulus results is discussed, and several reasonable suggestions for calculating and optimizing the certain bi-modulus member in practical engineering are presented. 展开更多
关键词 bi-modulus beam Winkler foundation temperature stress analytical so-lution secondary development of program
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Application of Mindsets to Health Education and Behavior Change Programs 被引量:2
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作者 Jordan Losavio Elizabeth Gollub 《Health》 CAS 2022年第4期407-417,共11页
Successful health promotion programs are characterized in part, by the willingness of audiences to engage, participate, and adopt healthier behaviors. But presentation of messages that reach and resonate with the inte... Successful health promotion programs are characterized in part, by the willingness of audiences to engage, participate, and adopt healthier behaviors. But presentation of messages that reach and resonate with the intended audience remains challenging. This is due in part to the variety of mindsets—viewpoints, attitudes, and beliefs—within a population. These mindsets play an essential role in understanding and predicting behaviors and lifestyle factors associated with health or chronic diseases. The purpose of this study is to demonstrate how a specific survey-based method of mindset segmentation can distinguish predominant mindsets and then be used to create, adapt, and/or market health programs to appeal to these mindsets. Steps in survey construction, distribution, and analysis are described. Interpretation of the results, yielding three primary mindsets, is the critical outcome of this segmentation method. The applications of this interpretation to community health education programs are suggested. This approach has potential to inform, enhance, or customize programs, tailoring activities, methods, and messages to the preferences of the community. 展开更多
关键词 Mindset Segmentation Health Promotion Cognitive Science Community Program Development
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An Early Warning Model of Telecommunication Network Fraud Based on User Portrait 被引量:1
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作者 Wen Deng Guangjun Liang +3 位作者 Chenfei Yu Kefan Yao Chengrui Wang Xuan Zhang 《Computers, Materials & Continua》 SCIE EI 2023年第4期1561-1576,共16页
With the frequent occurrence of telecommunications and networkfraud crimes in recent years, new frauds have emerged one after another whichhas caused huge losses to the people. However, due to the lack of an effective... With the frequent occurrence of telecommunications and networkfraud crimes in recent years, new frauds have emerged one after another whichhas caused huge losses to the people. However, due to the lack of an effectivepreventive mechanism, the police are often in a passive position. Usingtechnologies such as web crawlers, feature engineering, deep learning, andartificial intelligence, this paper proposes a user portrait fraudwarning schemebased on Weibo public data. First, we perform preliminary screening andcleaning based on the keyword “defrauded” to obtain valid fraudulent userIdentity Documents (IDs). The basic information and account information ofthese users is user-labeled to achieve the purpose of distinguishing the typesof fraud. Secondly, through feature engineering technologies such as avatarrecognition, Artificial Intelligence (AI) sentiment analysis, data screening,and follower blogger type analysis, these pictures and texts will be abstractedinto user preferences and personality characteristics which integrate multidimensionalinformation to build user portraits. Third, deep neural networktraining is performed on the cube. 80% percent of the data is predicted basedon the N-way K-shot problem and used to train the model, and the remaining20% is used for model accuracy evaluation. Experiments have shown thatFew-short learning has higher accuracy compared with Long Short TermMemory (LSTM), Recurrent Neural Networks (RNN) and ConvolutionalNeural Network (CNN). On this basis, this paper develops a WeChat smallprogram for early warning of telecommunications network fraud based onuser portraits. When the user enters some personal information on the frontend, the back-end database can perform correlation analysis by itself, so as tomatch the most likely fraud types and give relevant early warning information.The fraud warning model is highly scaleable. The data of other Applications(APPs) can be extended to further improve the efficiency of anti-fraud whichhas extremely high public welfare value. 展开更多
关键词 CRAWLER user portrait feature engineering deep learning small program development
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COMPUTER PROGRAM FOR DIRECTED STRUCTURE TOPOLOGY OPTIMIZATION 被引量:1
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作者 Xianjie Wang Xun'an Zhang Kepeng Cheng 《Acta Mechanica Solida Sinica》 SCIE EI CSCD 2015年第4期431-440,共10页
To compensate for the imperfection of traditional bi-directional evolutionary structural optimization, material interpolation scheme and sensitivity filter functions are introduced. A suitable filter can overcome the ... To compensate for the imperfection of traditional bi-directional evolutionary structural optimization, material interpolation scheme and sensitivity filter functions are introduced. A suitable filter can overcome the checkerboard and mesh-dependency. And the historical information on accurate elemental sensitivity numbers are used to keep the objective function converging steadily. Apart from rational intervals of the relevant important parameters, the concept of distinguishing between active and non-active elements design is proposed, which can be widely used for improving the function and artistry of structures directly, especially for a one whose accurate size is not given. Furthermore, user-friendly software packages are developed to enhance its accessibility for practicing engineers and architects. And to reduce the time cost for large timeconsuming complex structure optimization, parallel computing is built-in in the MATLAB codes. The program is easy to use for engineers who may not be familiar with either FEA or structure optimization. And developers can make a deep research on the algorithm by changing the MATLAB codes. Several classical examples are given to show that the improved BESO method is superior for its handy and utility computer program software. 展开更多
关键词 bi-directional evolutionary structural optimization (BESO) continuum structurescomputer program development improved algorithm directed structure topology optimizationportion construction design
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Designing a Comprehensive Skill Evaluation and Vocational Ability Development Program for FTTH Installer 被引量:1
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作者 Takuo Kikuchi 《Computer Technology and Application》 2015年第1期5-13,共9页
Recently, FTTH (fiber to the home) is spreading rapidly, and communication technology has become an indispensable part in our lives. FTTH installers who build the infi'astructure must correspond to the progress of ... Recently, FTTH (fiber to the home) is spreading rapidly, and communication technology has become an indispensable part in our lives. FTTH installers who build the infi'astructure must correspond to the progress of technology while ensuring a high quality of installation, and it is struggling to its counterpart. The present study is undertaken in order to propose effective vocational ability development program for FTTH installers from the approach of their skill. They are information network cabling-related qualification system and competitions as the ability evaluation system. Then the author concludes that this program makes a contribution to improving their skill and maintaining the quality of the optical fiber network in analyzing some example of actual installation work and the measurement result of the OTDR(optical time domain reflect) meter. 展开更多
关键词 Vocational ability development program FTTH installer installation skill evaluation system.
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Innovation-driven efficient development of the Longwangmiao Fm large-scale sulfur gas reservoir in Moxi block,Sichuan Basin 被引量:3
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作者 Ma Xinhua 《Natural Gas Industry B》 2016年第2期99-107,共9页
The Lower Cambrian Longwangmiao Fm gas reservoir in Moxi block of the Anyue Gas field,Sichuan Basin,is the largest single-sandbody integrated carbonate gas reservoir proved so far in China.Notwithstanding this reservo... The Lower Cambrian Longwangmiao Fm gas reservoir in Moxi block of the Anyue Gas field,Sichuan Basin,is the largest single-sandbody integrated carbonate gas reservoir proved so far in China.Notwithstanding this reservoir's advantages like large-scale reserves and high singlewell productivity,there are multiple complicated factors restricting its efficient development,such as a median content of hydrogen sulfide,low porosity and strong heterogeneity of fractureecave formation,various modes of gasewater occurrences,and close relation between overpressure and stress sensitivity.Up till now,since only a few Cambrian large-scale carbonate gas reservoirs have ever been developed in the world,there still exists some blind spots especially about its exploration and production rules.Besides,as for large-scale sulfur gas reservoirs,the exploration and construction is costly,and production test in the early evaluation stage is severely limited,all of which will bring about great challenges in productivity construction and high potential risks.In this regard,combining with Chinese strategic demand of strengthening clean energy supply security,the PetroChina Southwest Oil&Gas Field Company has carried out researches and field tests for the purpose of providing highproduction wells,optimizing development design,rapidly constructing high-quality productivity and upgrading HSE security in the Longwangmiao Fm gas reservoir in Moxi block.Through the innovations of technology and management mode within 3 years,this gas reservoir has been built into a modern large-scale gas field with high quality,high efficiency and high benefit,and its annual capacity is now up to over 100×10^(8)m^(3),with a desirable production capacity and development indexes gained as originally anticipated.It has become a new model of large-scale gas reservoirs with efficient development,providing a reference for other types of gas reservoirs in China. 展开更多
关键词 Sichuan Basin Early Cambrian Longwangmiao Fm LARGE-SCALE Carbonate Sulfur gas reservoir Efficient development Development evaluation Development program Productivity construction
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The Elite Strategies in the CIMS Subject of China 863 Program (1986-2000)
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作者 赵新力 Zhang Chao 《High Technology Letters》 EI CAS 2003年第1期64-67,共4页
Manpower is the key factor to the success of the CIMS Subject of China 863 Program. Many manpower strategies have been used in the CIMS Subject, which include elite strategies, training and practicing strategies, and ... Manpower is the key factor to the success of the CIMS Subject of China 863 Program. Many manpower strategies have been used in the CIMS Subject, which include elite strategies, training and practicing strategies, and culture strategies. This paper is mainly about the elite strategies such as to discover the talents, to cultivate the elites and to establish the mechanism for the expert groups to work in team, echelon and vigor. 展开更多
关键词 CIMS MANPOWER STRATEGIES management HI-TECH national research and development program
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The Drive to Develop China's West: An Inclusive Perspective
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作者 魏后凯 谢先树 《China Economist》 2011年第4期16-25,共10页
Since the launching of the western regional development program in 1999, the Chinese government has implemented a series of policy measures related to finance, taxation, investment, banking, and other related fields. ... Since the launching of the western regional development program in 1999, the Chinese government has implemented a series of policy measures related to finance, taxation, investment, banking, and other related fields. This combination of policies has stimulated socioeconomic growth and ecological improvement in China's western regions and has effectively curbed the runaway gap between the east and west, even causing the gap to begin shrinking gradually. However, it should be noted that the development gap between China's eastern and western regions remains significant, as demonstrated by the west's low level of industrial^commercial development, local governments' limited capacity to provide public services, and endemic rural poverty. Thus, achieving the targets outlined in the western regional development program remains a challenging task. In the future, China's western development program should emphasize a higher standard of living and coordinated, inclusive growth across regions. 展开更多
关键词 China western regional development program regional coordinateddevelopment inclusive growth
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Program for the Development of Chinese Women (2001-2010)
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《China Population Today》 2001年第6期2-6,共5页
关键词 Program for the Development of Chinese Women 2010
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China's Biotechnology Development Program during the Tenth Five-Year Plan Period (2001-2005)
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《China's Foreign Trade》 2002年第6期46-46,共1页
Bioengineering TechnoIogy(Ⅰ)1. Crop molecular marker-assisted selection and pyramiding breeding technology2. Super hybrid
关键词 high China’s Biotechnology Development Program during the Tenth Five-Year Plan Period
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Design and Implementation of a Photovoltaic Data Acquisition System for Some Meteorological Variables
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作者 Nicholas N. Tasie Friday B. Sigalo +1 位作者 Valentine B. Omubo-Pepple Chigozie Israel-Cookey 《Energy and Power Engineering》 CAS 2022年第11期652-668,共17页
In this paper we have developed a data logging and monitoring system, we validated the system by comparing the result from it with the existing one and found that the system performs slightly better than the existing ... In this paper we have developed a data logging and monitoring system, we validated the system by comparing the result from it with the existing one and found that the system performs slightly better than the existing work in the same area. This implies that the data logger and monitoring system is good and can be used to monitor solar energy variables even at the comfort of our homes. We fitted a model to the generated data and found that the meteorological variables considered accounted for 99.88% of the power output in the rainy seasons while 0.12% of the variation was not explained due to other factors. Solar panels inclined at an angle of 5&deg; (Tilt) and facing South Pole perform optimally. 展开更多
关键词 Data Logging and Monitoring System Circuit Design Development Chip programming and Software Development Photovoltaic Cell Meteorological Parameters
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Program for the Development of Chinese Women(2001-2010)
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《China Population Today》 2001年第5期2-5,共4页
关键词 Program for the Development of Chinese Women 2010
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