Based on the survey on wild plants in 21 counties( cities) in Yichun Area,89 species of 32 families of wild vegetables were collected. The species,parts,edible parts,distribution and current development and use of wil...Based on the survey on wild plants in 21 counties( cities) in Yichun Area,89 species of 32 families of wild vegetables were collected. The species,parts,edible parts,distribution and current development and use of wild vegetables in Yichun Area were expounded. Then,existing problems of wild vegetables in Yichun Area were discussed. Finally,pertinent recommendations were put forward.展开更多
In hearing physiological experiments and clinic tests,we need not only a signal processing system,but also a synchronous sound stimulator’ Most of stimulators we are now using are function generators which are indepe...In hearing physiological experiments and clinic tests,we need not only a signal processing system,but also a synchronous sound stimulator’ Most of stimulators we are now using are function generators which are independent to processing units,and can be controlled only by hand. Although some of them have ports through which they can be controlled by computer,but as they are designed for industrial aims,not for hearing research,most of them can’t generate the special waveforms we need. We use the TDT signal processing system and develop a software package have both usage. On the interface of the program we can control the sampling parameters and generate stimulating waveforms’展开更多
Many landscape plants have edible,medicinal,forage,industrial and other economic value,which has not been fully exploited.Effective development and utilization of the economic value of city landscape plant,conforms to...Many landscape plants have edible,medicinal,forage,industrial and other economic value,which has not been fully exploited.Effective development and utilization of the economic value of city landscape plant,conforms to the need of sustainable development and economical society,which is of great significance to the development of urban ecological civilization construction. In this paper,the landscape plant species in Shijiazhuang City and their economic value are investigated and analyzed,the principle and scheme of economic development and utilization of landscape plants in Shijiazhuang city value are put forward,which provides the reference for full and sustainable utilization of landscape plant resources in Shijiazhuang City.展开更多
As important means of coordinating human-land relationship and realizing optimum allocation of land resources,land consolidation plays a great role in increasing effective farmland area and realizing dynamic balance o...As important means of coordinating human-land relationship and realizing optimum allocation of land resources,land consolidation plays a great role in increasing effective farmland area and realizing dynamic balance of total farmland area. Land consolidation includes reallocation of land in space and adjustment of land relationship. This paper elaborated necessities for integrated land consolidation in Tongjiang County from project implementation,implementation situations,and implementation characteristics.展开更多
Mobile finance plays a great role in solving problems of rural finance,such as insufficient physical outlets and excessive high transaction cost. Based on the field survey data of Village A in Sichuan Province,analysi...Mobile finance plays a great role in solving problems of rural finance,such as insufficient physical outlets and excessive high transaction cost. Based on the field survey data of Village A in Sichuan Province,analysis and study were carried out on the development and use of rural mobile finance. The results indicated that the degree of use of rural mobile finance is not high. Mobile finance is mainly used in the young and the middle aged people with high educational level,engaged in non-agricultural industry,and with lower middle income. The business is single and mainly concentrated in shopping and transfer of account.展开更多
1.Background The United Nations(UN)2030 Agenda for Sustainable Development,adopted in 2015,established the Sustainable Development Goals(SDGs)as a comprehensive framework to address global challenges through interconn...1.Background The United Nations(UN)2030 Agenda for Sustainable Development,adopted in 2015,established the Sustainable Development Goals(SDGs)as a comprehensive framework to address global challenges through interconnected social,economic,and environmental targets.展开更多
Reconciling biodiversity conservation with economic advancement represents a defining challenge of the Anthropocene epoch.Although ecotourism is widely promoted as a strategy capable of delivering both environmental a...Reconciling biodiversity conservation with economic advancement represents a defining challenge of the Anthropocene epoch.Although ecotourism is widely promoted as a strategy capable of delivering both environmental and developmental benefits,empirical evidence regarding its ecological and socioeconomic impacts remains limited.This study critically examined the Hide-in-Bird Pond(HIBP)model,a rapidly expanding,community-based avitourism framework in China that integrates targeted wildlife provisioning with concealed infrastructure for bird observation,simultaneously establishing a novel income source for economically marginalized rural regions through ecotourism.Semi-structured online interviews were conducted with 98 HIBP operators,and thematic analysis was applied to evaluate current developmental patterns,spatial distribution,and conservation outcomes.A total of 251 HIBP sites were identified across China,predominantly located in biodiversity-rich but economically marginalized regions.These sites collectively supported 524 bird species—36%of China's avifauna—including 148 species classified as nationally protected or threatened(38%of nationally listed bird taxa).These findings suggest that HIBP can serve as an integrative socio-ecological platform that aligns conservation objectives with sustainable rural development.However,the absence of standardized governance frameworks and ecological safeguards poses significant risks to biodiversity an d long-term sustainability.Implementation of science-based adaptive management systems,incorporating systematic biodiversity monitoring,inclusive stakeholder coordination,and certified sustainable tourism protocols,is critical to ensure ecological integrity and sectoral resilience.These findings offer novel insights into aligning conservation objectives with economic development across regions characterized by high biodiversity and persistent economic disadvantage.展开更多
The International Standardization Youth Star Competition is held for three consecutive years.We have witnessed continuous improvement in the competition each year,which is a result of our collective efforts.
Environmental DNA(eDNA)technology has revolutionized biodiversity monitoring with its non-invasive,sensitive,and cost-efficient approach.This paper systematically reviews eDNA advancements,examining its applications i...Environmental DNA(eDNA)technology has revolutionized biodiversity monitoring with its non-invasive,sensitive,and cost-efficient approach.This paper systematically reviews eDNA advancements,examining its applications in aquatic and terrestrial ecosystems and assessing China’s standardization progress.It delineates four developmental phases from single-species detection to high-throughput sequencing,and highlights China’s contribution to the development of technical standards.While significant progress has been made,challenges persist in quantitative accuracy,methodological consistency,and large-scale implementation.Future efforts should prioritize enhanced standardization,improved quantification techniques,broader applications,and international collaboration to drive innovation in eDNA technology.展开更多
In recent years, the digital economy has become a key driver of deepening China-Thailand cooperation. As trade and industrial digitalization advance, artificial intelligence (AI), an essential force in the new wave of...In recent years, the digital economy has become a key driver of deepening China-Thailand cooperation. As trade and industrial digitalization advance, artificial intelligence (AI), an essential force in the new wave of technological revolution, is increasingly embedded in the bilateral agenda, steering collaboration beyond efficiencydriven “digital coordination” toward more structured and systemic“intelligent co-development.”Building on five decades of mutual trust since the establishment of diplomatic ties, this cooperation not only addresses the practical needs of industrial upgrading and governance transformation but offers a valuable reference for ASEAN countries exploring replicable pathways in the era of digital transformation.展开更多
The 17 Sustainable Development Goals(SDGs)for 2030,adopted by all United Nations member states in 2015,are facing a range of challenges.Factors such as climate change,regional conflicts and economic recession are havi...The 17 Sustainable Development Goals(SDGs)for 2030,adopted by all United Nations member states in 2015,are facing a range of challenges.Factors such as climate change,regional conflicts and economic recession are having a significant impact,particularly on global poverty governance.As a platform for dialogue,exchange and technical cooperation,the 2025 International Seminar on Global Poverty Reduction Partnerships was held in Beijing on 10 December 2025.展开更多
Floodplain wetlands are invaluable ecosystems providing numerous ecological benefits,yet they face a global crisis necessitating sustainable preservation efforts.This study examines the depletion of floodplain wetland...Floodplain wetlands are invaluable ecosystems providing numerous ecological benefits,yet they face a global crisis necessitating sustainable preservation efforts.This study examines the depletion of floodplain wetlands within the Hastinapur Wildlife Sanctuary(HWLS)in Uttar Pradesh.Encroachment activities such as grazing,agriculture,and human settlements have fragmented and degraded critical wetland ecosystems.Additionally,irrigation projects,dam construction,and water diversion have disrupted natural water flow and availability.To assess wetland inundation in 2023,five classification techniques were employed:Random Forest(RF),Support Vector Machine(SVM),artificial neural network(ANN),Spectral Information Divergence(SID),and Maximum Likelihood Classifier(MLC).SVM emerged as the most precise method,as determined by kappa coefficient and index-based validation.Consequently,the SVM classifier was used to model wetland inundation areas from 1983 to 2023 and analyze spatiotemporal changes and fragmentation patterns.The findings revealed that the SVM clas-sifier accurately mapped 2023 wetland areas.The modeled time-series data demonstrated a 62.55%and 38.12%reduction in inundated wetland areas over the past 40 years in the pre-and post-monsoon periods,respectively.Fragmentation analysis indicated an 86.27%decrease in large core wetland areas in the pre-monsoon period,signifying severe habitat degradation.This rapid decline in wetlands within protected areas raises concerns about their ecological impacts.By linking wetland loss to global sustainability objectives,this study underscores the global urgency for strengthened wetland protection measures and highlights the need for integrating wetland conservation into broader sustainable development goals.Effective policies and adaptive management strategies are crucial for preserving these ecosystems and their vital services,which are essential for biodiversity,climate regulation,and human well-being.展开更多
The demand for Erigeron breviscapus,a medicinal Compositae plant with cardiovascular therapeutic properties,has been increasing by 15%annually,exceeding production capacity and necessitating improvements in yield and ...The demand for Erigeron breviscapus,a medicinal Compositae plant with cardiovascular therapeutic properties,has been increasing by 15%annually,exceeding production capacity and necessitating improvements in yield and bioactive compound content.Genetic transformation remains essential for functional genomics,yet current Agrobacterium and biolistic methods are inefficient and expensive.In this study,we cloned the full-length sequences of the BABY BOOM,WUSCHEL and GROWTH-REGULATING FACTOR(GRF)genes of E.breviscapus and then transformed them into E.breviscapus explants.The transformation efficiency for the GRF gene reached 45%,and all the transgenic E.breviscapus plants were fertile without obvious developmental defects.Furthermore,we inserted EbGRF4 and Cas9-EbPDS-sgRNA into the same vector for Agrobacterium-mediated transformation to effectively knock out the PDS gene,resulting in albino seedlings,with a gene editing efficiency of 33.3%.These findings provide a solid foundation for functional genomic research and the genetic improvement of E.breviscapus,as well as an important reference for establishing high-efficiency genetic transformation systems for other medicinal plants.展开更多
Tooth developmental anomalies are a group of disorders caused by unfavorable factors affecting the tooth development process,resulting in abnormalities in tooth number,structure,and morphology.These anomalies typicall...Tooth developmental anomalies are a group of disorders caused by unfavorable factors affecting the tooth development process,resulting in abnormalities in tooth number,structure,and morphology.These anomalies typically manifest during childhood,impairing dental function,maxillofacial development,and facial aesthetics,while also potentially impacting overall physical and mental health.The complex etiology and diverse clinical phenotypes of these anomalies pose significant challenges for prevention,early diagnosis,and treatment.As they usually emerge early in life,long-term management and multidisciplinary collaboration in dental care are essential.However,there is currently a lack of systematic clinical guidelines for the diagnosis and treatment of these conditions,adding to the difficulties in clinical practice.In response to this need,this expert consensus summarizes the classifications,etiology,typical clinical manifestations,and diagnostic criteria of tooth developmental anomalies based on current clinical evidence.It also provides prevention strategies and stage-specific clinical management recommendations to guide clinicians in diagnosis and treatment,promoting early intervention and standardized care for these anomalies.展开更多
The mechanistic target of rapamycin(m TOR) is a serine/threonine kinase that plays a pivotal role in cellular growth, proliferation, survival, and metabolism. In the central nervous system(CNS), the mTOR pathway regul...The mechanistic target of rapamycin(m TOR) is a serine/threonine kinase that plays a pivotal role in cellular growth, proliferation, survival, and metabolism. In the central nervous system(CNS), the mTOR pathway regulates diverse aspects of neural development and function. Genetic mutations within the m TOR pathway lead to severe neurodevelopmental disorders, collectively known as “mTORopathies”(Crino, 2020). Dysfunctions of m TOR, including both its hyperactivation and hypoactivation, have also been implicated in a wide spectrum of other neurodevelopmental and neurodegenerative conditions, highlighting its importance in CNS health.展开更多
The organotypic retinal explant culture has been established for more than a decade and offers a range of unique advantages compared with in vivo experiments and cell cultures.However,the lack of systematic and contin...The organotypic retinal explant culture has been established for more than a decade and offers a range of unique advantages compared with in vivo experiments and cell cultures.However,the lack of systematic and continuous comparison between in vivo retinal development and the organotypic retinal explant culture makes this model controversial in postnatal retinal development studies.Thus,we aimed to verify the feasibility of using this model for postnatal retinal development studies by comparing it with the in vivo retina.In this study,we showed that postnatal retinal explants undergo normal development,and exhibit a consistent structure and timeline with retinas in vivo.Initially,we used SOX2 and PAX6 immunostaining to identify retinal progenitor cells.We then examined cell proliferation and migration by immunostaining with Ki-67 and doublecortin,respectively.Ki-67-and doublecortin-positive cells decreased in both in vivo and explants during postnatal retinogenesis,and exhibited a high degree of similarity in abundance and distribution between groups.Additionally,we used Ceh-10 homeodomain-containing homolog,glutamate-ammonia ligase(glutamine synthetase),neuronal nuclei,and ionized calcium-binding adapter molecule 1 immunostaining to examine the emergence of bipolar cells,Müller glia,mature neurons,and microglia,respectively.The timing and spatial patterns of the emergence of these cell types were remarkably consistent between in vivo and explant retinas.Our study showed that the organotypic retinal explant culture model had a high degree of consistency with the progression of in vivo early postnatal retina development.The findings confirm the accuracy and credibility of this model and support its use for long-term,systematic,and continuous observation.展开更多
Innovation and Development Policy,简称“IDP”,中文名:《创新与发展政策(英文)》,是由中国科学院主管,中国科学院科技战略咨询研究院、中国科学学与科技政策研究会共同主办,国内外发行(ISSN:2096-5141,CN:10-1513/D)的英文国际期刊...Innovation and Development Policy,简称“IDP”,中文名:《创新与发展政策(英文)》,是由中国科学院主管,中国科学院科技战略咨询研究院、中国科学学与科技政策研究会共同主办,国内外发行(ISSN:2096-5141,CN:10-1513/D)的英文国际期刊。目前期刊每年出版两期。已发表论文在期刊网站可以自由获取,http://idp-journal.casisd.cn/browse/al/al2019/。展开更多
The United Nations Sustainable Development Goal(SDG) 2 aims to achieve Zero Hunger by 2030.However,global hunger and food insecurity have continued to rise at an alarming rate(UN 2023).Subtropical regions are home to ...The United Nations Sustainable Development Goal(SDG) 2 aims to achieve Zero Hunger by 2030.However,global hunger and food insecurity have continued to rise at an alarming rate(UN 2023).Subtropical regions are home to more than 30% of the world's population,predominantly in developing countries where per capita farmland and food supply are only 40% of those in developed nations(FAO 2018).Meeting the Zero Hunger target amid ongoing population growth in these regions requires a substantial increase in agricultural production while minimizing soil degradation and adverse ecological impacts.This challenge is shared by many countries across South Asia,Africa,and Central and South America.展开更多
Standards are the common language that consolidates global consensus and builds the most solid foundation for international partnerships.They are the cornerstone for global sustainable and high-quality development.You...Standards are the common language that consolidates global consensus and builds the most solid foundation for international partnerships.They are the cornerstone for global sustainable and high-quality development.Young students,with their active and vibrant minds,represent the future and hope of standardization.展开更多
In the lush heart of Uganda’s Busoga sub-region,Isaac Imaka is charting a new course for rural development.After seven years in national media,he left the newsroom and stepped into the soil.The former reporter with t...In the lush heart of Uganda’s Busoga sub-region,Isaac Imaka is charting a new course for rural development.After seven years in national media,he left the newsroom and stepped into the soil.The former reporter with the Daily Monitor was driven by the belief that communities like his in Jinja North deserved more than chronic poverty and hand-to-mouth survival.展开更多
文摘Based on the survey on wild plants in 21 counties( cities) in Yichun Area,89 species of 32 families of wild vegetables were collected. The species,parts,edible parts,distribution and current development and use of wild vegetables in Yichun Area were expounded. Then,existing problems of wild vegetables in Yichun Area were discussed. Finally,pertinent recommendations were put forward.
文摘In hearing physiological experiments and clinic tests,we need not only a signal processing system,but also a synchronous sound stimulator’ Most of stimulators we are now using are function generators which are independent to processing units,and can be controlled only by hand. Although some of them have ports through which they can be controlled by computer,but as they are designed for industrial aims,not for hearing research,most of them can’t generate the special waveforms we need. We use the TDT signal processing system and develop a software package have both usage. On the interface of the program we can control the sampling parameters and generate stimulating waveforms’
基金Supported by Funds for the Development of Key Disciplines in Hebei UniversitiesUniversity-level Platform Research Project of Shijiazhuang University in 2013(XJPT011)
文摘Many landscape plants have edible,medicinal,forage,industrial and other economic value,which has not been fully exploited.Effective development and utilization of the economic value of city landscape plant,conforms to the need of sustainable development and economical society,which is of great significance to the development of urban ecological civilization construction. In this paper,the landscape plant species in Shijiazhuang City and their economic value are investigated and analyzed,the principle and scheme of economic development and utilization of landscape plants in Shijiazhuang city value are put forward,which provides the reference for full and sustainable utilization of landscape plant resources in Shijiazhuang City.
文摘As important means of coordinating human-land relationship and realizing optimum allocation of land resources,land consolidation plays a great role in increasing effective farmland area and realizing dynamic balance of total farmland area. Land consolidation includes reallocation of land in space and adjustment of land relationship. This paper elaborated necessities for integrated land consolidation in Tongjiang County from project implementation,implementation situations,and implementation characteristics.
基金Supported by the Innovation Project for College Young Teachers in Tibet Autonomous Region(QC2015-31)
文摘Mobile finance plays a great role in solving problems of rural finance,such as insufficient physical outlets and excessive high transaction cost. Based on the field survey data of Village A in Sichuan Province,analysis and study were carried out on the development and use of rural mobile finance. The results indicated that the degree of use of rural mobile finance is not high. Mobile finance is mainly used in the young and the middle aged people with high educational level,engaged in non-agricultural industry,and with lower middle income. The business is single and mainly concentrated in shopping and transfer of account.
文摘1.Background The United Nations(UN)2030 Agenda for Sustainable Development,adopted in 2015,established the Sustainable Development Goals(SDGs)as a comprehensive framework to address global challenges through interconnected social,economic,and environmental targets.
基金supported by the Gaoligong Mountain Ecological Function Enhancement and Sustainable Development Technology Research(202303AC1000120303)Gaoligong Mountain Ecological Function Enhancement and Invasive Plant Species Prevention and Control Technology Project(2022YFF130240304)National Key R&D Program of China(2022YFC2602500)。
文摘Reconciling biodiversity conservation with economic advancement represents a defining challenge of the Anthropocene epoch.Although ecotourism is widely promoted as a strategy capable of delivering both environmental and developmental benefits,empirical evidence regarding its ecological and socioeconomic impacts remains limited.This study critically examined the Hide-in-Bird Pond(HIBP)model,a rapidly expanding,community-based avitourism framework in China that integrates targeted wildlife provisioning with concealed infrastructure for bird observation,simultaneously establishing a novel income source for economically marginalized rural regions through ecotourism.Semi-structured online interviews were conducted with 98 HIBP operators,and thematic analysis was applied to evaluate current developmental patterns,spatial distribution,and conservation outcomes.A total of 251 HIBP sites were identified across China,predominantly located in biodiversity-rich but economically marginalized regions.These sites collectively supported 524 bird species—36%of China's avifauna—including 148 species classified as nationally protected or threatened(38%of nationally listed bird taxa).These findings suggest that HIBP can serve as an integrative socio-ecological platform that aligns conservation objectives with sustainable rural development.However,the absence of standardized governance frameworks and ecological safeguards poses significant risks to biodiversity an d long-term sustainability.Implementation of science-based adaptive management systems,incorporating systematic biodiversity monitoring,inclusive stakeholder coordination,and certified sustainable tourism protocols,is critical to ensure ecological integrity and sectoral resilience.These findings offer novel insights into aligning conservation objectives with economic development across regions characterized by high biodiversity and persistent economic disadvantage.
文摘The International Standardization Youth Star Competition is held for three consecutive years.We have witnessed continuous improvement in the competition each year,which is a result of our collective efforts.
基金supported by the National Natural Science Foundation of China(Grant No.32160172)the Key Science-Technology Project of Inner Mongolia(2023KYPT0010)+1 种基金the Natural Science Foundation of Inner Mongolia Autonomous Region of China(Grant No.2025QN03006)the 2023 Inner Mongolia Public Institution High-Level Talent Introduction Scientific Research Support Project.
文摘Environmental DNA(eDNA)technology has revolutionized biodiversity monitoring with its non-invasive,sensitive,and cost-efficient approach.This paper systematically reviews eDNA advancements,examining its applications in aquatic and terrestrial ecosystems and assessing China’s standardization progress.It delineates four developmental phases from single-species detection to high-throughput sequencing,and highlights China’s contribution to the development of technical standards.While significant progress has been made,challenges persist in quantitative accuracy,methodological consistency,and large-scale implementation.Future efforts should prioritize enhanced standardization,improved quantification techniques,broader applications,and international collaboration to drive innovation in eDNA technology.
文摘In recent years, the digital economy has become a key driver of deepening China-Thailand cooperation. As trade and industrial digitalization advance, artificial intelligence (AI), an essential force in the new wave of technological revolution, is increasingly embedded in the bilateral agenda, steering collaboration beyond efficiencydriven “digital coordination” toward more structured and systemic“intelligent co-development.”Building on five decades of mutual trust since the establishment of diplomatic ties, this cooperation not only addresses the practical needs of industrial upgrading and governance transformation but offers a valuable reference for ASEAN countries exploring replicable pathways in the era of digital transformation.
文摘The 17 Sustainable Development Goals(SDGs)for 2030,adopted by all United Nations member states in 2015,are facing a range of challenges.Factors such as climate change,regional conflicts and economic recession are having a significant impact,particularly on global poverty governance.As a platform for dialogue,exchange and technical cooperation,the 2025 International Seminar on Global Poverty Reduction Partnerships was held in Beijing on 10 December 2025.
基金support through the“Trans-Disciplinary Research”Grant(No.R/Dev/IoE/TDRProjects/2023-24/61658),which played a crucial role in enabling this research endeavor.
文摘Floodplain wetlands are invaluable ecosystems providing numerous ecological benefits,yet they face a global crisis necessitating sustainable preservation efforts.This study examines the depletion of floodplain wetlands within the Hastinapur Wildlife Sanctuary(HWLS)in Uttar Pradesh.Encroachment activities such as grazing,agriculture,and human settlements have fragmented and degraded critical wetland ecosystems.Additionally,irrigation projects,dam construction,and water diversion have disrupted natural water flow and availability.To assess wetland inundation in 2023,five classification techniques were employed:Random Forest(RF),Support Vector Machine(SVM),artificial neural network(ANN),Spectral Information Divergence(SID),and Maximum Likelihood Classifier(MLC).SVM emerged as the most precise method,as determined by kappa coefficient and index-based validation.Consequently,the SVM classifier was used to model wetland inundation areas from 1983 to 2023 and analyze spatiotemporal changes and fragmentation patterns.The findings revealed that the SVM clas-sifier accurately mapped 2023 wetland areas.The modeled time-series data demonstrated a 62.55%and 38.12%reduction in inundated wetland areas over the past 40 years in the pre-and post-monsoon periods,respectively.Fragmentation analysis indicated an 86.27%decrease in large core wetland areas in the pre-monsoon period,signifying severe habitat degradation.This rapid decline in wetlands within protected areas raises concerns about their ecological impacts.By linking wetland loss to global sustainability objectives,this study underscores the global urgency for strengthened wetland protection measures and highlights the need for integrating wetland conservation into broader sustainable development goals.Effective policies and adaptive management strategies are crucial for preserving these ecosystems and their vital services,which are essential for biodiversity,climate regulation,and human well-being.
基金supported by the National Natural Science Foundation of China(82160727)the Major Science and Technique Programs in Yunnan Province(202304BT090021-ML05)Yunnan Agricultural University research start-up Fund(KY2022-02).
文摘The demand for Erigeron breviscapus,a medicinal Compositae plant with cardiovascular therapeutic properties,has been increasing by 15%annually,exceeding production capacity and necessitating improvements in yield and bioactive compound content.Genetic transformation remains essential for functional genomics,yet current Agrobacterium and biolistic methods are inefficient and expensive.In this study,we cloned the full-length sequences of the BABY BOOM,WUSCHEL and GROWTH-REGULATING FACTOR(GRF)genes of E.breviscapus and then transformed them into E.breviscapus explants.The transformation efficiency for the GRF gene reached 45%,and all the transgenic E.breviscapus plants were fertile without obvious developmental defects.Furthermore,we inserted EbGRF4 and Cas9-EbPDS-sgRNA into the same vector for Agrobacterium-mediated transformation to effectively knock out the PDS gene,resulting in albino seedlings,with a gene editing efficiency of 33.3%.These findings provide a solid foundation for functional genomic research and the genetic improvement of E.breviscapus,as well as an important reference for establishing high-efficiency genetic transformation systems for other medicinal plants.
基金supported by the grants No.82370912 from the National Natural Science Foundation of ChinaNo.2022020801010499 from the Bureau of Science and Technology of Wuhan,ChinaNo.2042023kf0231 from the Fundamental Research Funds for the Central Universities,China。
文摘Tooth developmental anomalies are a group of disorders caused by unfavorable factors affecting the tooth development process,resulting in abnormalities in tooth number,structure,and morphology.These anomalies typically manifest during childhood,impairing dental function,maxillofacial development,and facial aesthetics,while also potentially impacting overall physical and mental health.The complex etiology and diverse clinical phenotypes of these anomalies pose significant challenges for prevention,early diagnosis,and treatment.As they usually emerge early in life,long-term management and multidisciplinary collaboration in dental care are essential.However,there is currently a lack of systematic clinical guidelines for the diagnosis and treatment of these conditions,adding to the difficulties in clinical practice.In response to this need,this expert consensus summarizes the classifications,etiology,typical clinical manifestations,and diagnostic criteria of tooth developmental anomalies based on current clinical evidence.It also provides prevention strategies and stage-specific clinical management recommendations to guide clinicians in diagnosis and treatment,promoting early intervention and standardized care for these anomalies.
基金supported by grants from Simons Foundation (SFARI 479754),CIHR (PJT-180565)the Scottish Rite Charitable Foundation of Canada (to YL)funding from the Canada Research Chairs program。
文摘The mechanistic target of rapamycin(m TOR) is a serine/threonine kinase that plays a pivotal role in cellular growth, proliferation, survival, and metabolism. In the central nervous system(CNS), the mTOR pathway regulates diverse aspects of neural development and function. Genetic mutations within the m TOR pathway lead to severe neurodevelopmental disorders, collectively known as “mTORopathies”(Crino, 2020). Dysfunctions of m TOR, including both its hyperactivation and hypoactivation, have also been implicated in a wide spectrum of other neurodevelopmental and neurodegenerative conditions, highlighting its importance in CNS health.
基金supported by the National Natural Science Foundation of China,Nos.81901156(to ZZ),82271200(to ZZ),82171308(to XC)the Fundamental Research Funds for the Central Universities,No.xzy012022035(to ZZ)+1 种基金the Natural Science Foundation of Shaanxi Province,Nos.2021JM-261(to QK),2023-YBSF-303(to ZZ)Traditional Chinese Medicine Project of Shaanxi Province,No.2019-ZZ-JC047(to QK)。
文摘The organotypic retinal explant culture has been established for more than a decade and offers a range of unique advantages compared with in vivo experiments and cell cultures.However,the lack of systematic and continuous comparison between in vivo retinal development and the organotypic retinal explant culture makes this model controversial in postnatal retinal development studies.Thus,we aimed to verify the feasibility of using this model for postnatal retinal development studies by comparing it with the in vivo retina.In this study,we showed that postnatal retinal explants undergo normal development,and exhibit a consistent structure and timeline with retinas in vivo.Initially,we used SOX2 and PAX6 immunostaining to identify retinal progenitor cells.We then examined cell proliferation and migration by immunostaining with Ki-67 and doublecortin,respectively.Ki-67-and doublecortin-positive cells decreased in both in vivo and explants during postnatal retinogenesis,and exhibited a high degree of similarity in abundance and distribution between groups.Additionally,we used Ceh-10 homeodomain-containing homolog,glutamate-ammonia ligase(glutamine synthetase),neuronal nuclei,and ionized calcium-binding adapter molecule 1 immunostaining to examine the emergence of bipolar cells,Müller glia,mature neurons,and microglia,respectively.The timing and spatial patterns of the emergence of these cell types were remarkably consistent between in vivo and explant retinas.Our study showed that the organotypic retinal explant culture model had a high degree of consistency with the progression of in vivo early postnatal retina development.The findings confirm the accuracy and credibility of this model and support its use for long-term,systematic,and continuous observation.
文摘Innovation and Development Policy,简称“IDP”,中文名:《创新与发展政策(英文)》,是由中国科学院主管,中国科学院科技战略咨询研究院、中国科学学与科技政策研究会共同主办,国内外发行(ISSN:2096-5141,CN:10-1513/D)的英文国际期刊。目前期刊每年出版两期。已发表论文在期刊网站可以自由获取,http://idp-journal.casisd.cn/browse/al/al2019/。
文摘The United Nations Sustainable Development Goal(SDG) 2 aims to achieve Zero Hunger by 2030.However,global hunger and food insecurity have continued to rise at an alarming rate(UN 2023).Subtropical regions are home to more than 30% of the world's population,predominantly in developing countries where per capita farmland and food supply are only 40% of those in developed nations(FAO 2018).Meeting the Zero Hunger target amid ongoing population growth in these regions requires a substantial increase in agricultural production while minimizing soil degradation and adverse ecological impacts.This challenge is shared by many countries across South Asia,Africa,and Central and South America.
文摘Standards are the common language that consolidates global consensus and builds the most solid foundation for international partnerships.They are the cornerstone for global sustainable and high-quality development.Young students,with their active and vibrant minds,represent the future and hope of standardization.
文摘In the lush heart of Uganda’s Busoga sub-region,Isaac Imaka is charting a new course for rural development.After seven years in national media,he left the newsroom and stepped into the soil.The former reporter with the Daily Monitor was driven by the belief that communities like his in Jinja North deserved more than chronic poverty and hand-to-mouth survival.
