In recent years,with the continuous development of biotechnology and medical science and technology,therapeutic antibodies,as new biologics,have shown great potential and have become a research hotspot in the fields o...In recent years,with the continuous development of biotechnology and medical science and technology,therapeutic antibodies,as new biologics,have shown great potential and have become a research hotspot in the fields of oncology,autoimmune diseases,cardiovascular and neuroscience.Therapeutic antibodies refer to drugs or therapeutic methods for the treatment of diseases with specificity,high affinity and high efficiency antibody molecules prepared by biotechnological means.In this paper,we will systematically review the types of therapeutic antibodies,research progress,problems in research and development,mechanisms of action,and challenges faced in clinical applications.展开更多
The mechanistic target of rapamycin(m TOR) is a serine/threonine kinase that plays a pivotal role in cellular growth, proliferation, survival, and metabolism. In the central nervous system(CNS), the mTOR pathway regul...The mechanistic target of rapamycin(m TOR) is a serine/threonine kinase that plays a pivotal role in cellular growth, proliferation, survival, and metabolism. In the central nervous system(CNS), the mTOR pathway regulates diverse aspects of neural development and function. Genetic mutations within the m TOR pathway lead to severe neurodevelopmental disorders, collectively known as “mTORopathies”(Crino, 2020). Dysfunctions of m TOR, including both its hyperactivation and hypoactivation, have also been implicated in a wide spectrum of other neurodevelopmental and neurodegenerative conditions, highlighting its importance in CNS health.展开更多
Biomass-based hydrocarbon fuels,as one of the alternatives to traditional fossil fuels,have attracted considerable attention in the energy field due to their renewability and environmental benefits.This article provid...Biomass-based hydrocarbon fuels,as one of the alternatives to traditional fossil fuels,have attracted considerable attention in the energy field due to their renewability and environmental benefits.This article provides a systematic review of recent research progress in the chemical synthesis of biomass-based hydrocarbon fuels.It outlines the conversion pathways using feedstocks such as lipids,terpenoids,cellulose/hemicellulose,and lignin.Depending on the feedstock,various products with distinct structural characteristics can be prepared through reactions such as cyclization,condensation,and catalytic hydrogenation.Throughout the synthesis process,three key factors play a critical role:efficient catalyst development,production process optimization,and computational-chemistry-based molecular design.Finally,the article discusses future perspectives for biomass-based hydrocarbon fuel synthesis research.展开更多
First,statistics on the operational lines and mileage of urban rail transit in China are conducted.The results show that,as of Dec.31,2025,there were 60 cities with urban rail transit in operation nationwide,with a to...First,statistics on the operational lines and mileage of urban rail transit in China are conducted.The results show that,as of Dec.31,2025,there were 60 cities with urban rail transit in operation nationwide,with a total operational mileage of approximately 12837.8 km(excluding the electronic guideway rubber-tired system,there were 57 cities,with a total operational mileage of 12651.6 km).The metro system dominates,while low-capacity systems exhibit a multi-modal development pattern.Subsequently,the characteristics of China′s urban rail transit industry development are analyzed,indicating that:(1)It should closely align with the theme of urban intensive development,promote quality improvement and efficiency enhancement of existing lines,and focus on the supporting role of initial passenger flow for new line construction,multi-network integration,and economic and financial sustainability.(2)Significant innovative achievements have been made in safety resilience,green and low-carbon development,intelligent construction,and digital transformation.Finally,development recommendations for the"15th Five-Year Plan"period are proposed:promoting cost reduction and efficiency improvement in the rail transit industry,enhancing the operational efficiency of existing networks,continuously exploring railway services for urban commuting,strengthening external exchanges,and driving the"going global"strategy of the urban rail transit industry.展开更多
Innovation and Development Policy,简称“IDP”,中文名:《创新与发展政策(英文)》,是由中国科学院主管,中国科学院科技战略咨询研究院、中国科学学与科技政策研究会共同主办,国内外发行(ISSN:2096-5141,CN:10-1513/D)的英文国际期刊...Innovation and Development Policy,简称“IDP”,中文名:《创新与发展政策(英文)》,是由中国科学院主管,中国科学院科技战略咨询研究院、中国科学学与科技政策研究会共同主办,国内外发行(ISSN:2096-5141,CN:10-1513/D)的英文国际期刊。目前期刊每年出版两期。已发表论文在期刊网站可以自由获取,http://idp-journal.casisd.cn/browse/al/al2019/。展开更多
The United Nations Sustainable Development Goal(SDG) 2 aims to achieve Zero Hunger by 2030.However,global hunger and food insecurity have continued to rise at an alarming rate(UN 2023).Subtropical regions are home to ...The United Nations Sustainable Development Goal(SDG) 2 aims to achieve Zero Hunger by 2030.However,global hunger and food insecurity have continued to rise at an alarming rate(UN 2023).Subtropical regions are home to more than 30% of the world's population,predominantly in developing countries where per capita farmland and food supply are only 40% of those in developed nations(FAO 2018).Meeting the Zero Hunger target amid ongoing population growth in these regions requires a substantial increase in agricultural production while minimizing soil degradation and adverse ecological impacts.This challenge is shared by many countries across South Asia,Africa,and Central and South America.展开更多
Standards are the common language that consolidates global consensus and builds the most solid foundation for international partnerships.They are the cornerstone for global sustainable and high-quality development.You...Standards are the common language that consolidates global consensus and builds the most solid foundation for international partnerships.They are the cornerstone for global sustainable and high-quality development.Young students,with their active and vibrant minds,represent the future and hope of standardization.展开更多
China-Zimbabwe collaboration is creating new opportunities for innovation and development of youth Zimbabwe’s development has long faced obstacles linked to Western economic sanctions,measures that many view as unjus...China-Zimbabwe collaboration is creating new opportunities for innovation and development of youth Zimbabwe’s development has long faced obstacles linked to Western economic sanctions,measures that many view as unjust or unlawful.Yet,despite these constraints,Zimbabwe remains a nation rich in natural resources and endowed with a highly educated population,with its youth standing out as a particularly dynamic force.展开更多
The Outline of Women's Development in China(2021-2030)has proposed goals and supportive measures,to promote women's employment and entrepreneurship,and to guarantee equal rights and opportunities for women to ...The Outline of Women's Development in China(2021-2030)has proposed goals and supportive measures,to promote women's employment and entrepreneurship,and to guarantee equal rights and opportunities for women to participate in economic development.In the process of promoting high-quality economic development,China is upholding employment as a priority.展开更多
Land degradation,coupled with climate change impacts,poses serious threats to global land health and human well-being.Participatory scenario planning(PSP)has become a key tool for exploring these interconnected challe...Land degradation,coupled with climate change impacts,poses serious threats to global land health and human well-being.Participatory scenario planning(PSP)has become a key tool for exploring these interconnected challenges;however,its progress and effectiveness remain underexplored.This study reviews 46 papers,using PRISMA guidelines,to investigate how PSP supports sustainable land management and climate resilience.We document how PSP applications have evolved from a biophysical focus to one addressing broader environmental,societal,and economic challenges.Disparities in how participants engage across PSP phases document the need for more equitable and meaningful participation.Clustering future scenarios reveals the complex interconnections among ecological,social,and economic factors underpinning land management and climate resilience,underscoring the need for inclusive and integrated strategies.From the emerging trends,we identify opportunities to advance PSP implementation,including early engagement of decision-makers,balanced representation and equitable power dynamics,meaningful participation,cross-disciplinary collaboration,integration of human-nature relationships,and regular revision of future pathways.Overall,our review highlights PSP’s potential to co-create inclusive,equitable scenarios and actionable pathways towards sustainable and resilient land use futures.展开更多
Discussions on Chinese modernization are offering African countries both conceptual inspiration and practical references as they explore their own sustainable development paths.
In the lush heart of Uganda’s Busoga sub-region,Isaac Imaka is charting a new course for rural development.After seven years in national media,he left the newsroom and stepped into the soil.The former reporter with t...In the lush heart of Uganda’s Busoga sub-region,Isaac Imaka is charting a new course for rural development.After seven years in national media,he left the newsroom and stepped into the soil.The former reporter with the Daily Monitor was driven by the belief that communities like his in Jinja North deserved more than chronic poverty and hand-to-mouth survival.展开更多
Agricultural development is regarded as the most important foundation of China’s modernisation.According to the Recommendations of the CPC Central Committee for Formulating the 15th Five-Year Plan for National Econom...Agricultural development is regarded as the most important foundation of China’s modernisation.According to the Recommendations of the CPC Central Committee for Formulating the 15th Five-Year Plan for National Economic and Social Development(2026–2030),issues related to agriculture,rural areas and rural residents should be given top priority.In the coming years,China will promote coordinated urban and rural development,continue to consolidate and expand the achievements of poverty alleviation,ensure basic modern living conditions in rural areas,and accelerate progress in building a strong agricultural sector.展开更多
1.Background The United Nations(UN)2030 Agenda for Sustainable Development,adopted in 2015,established the Sustainable Development Goals(SDGs)as a comprehensive framework to address global challenges through interconn...1.Background The United Nations(UN)2030 Agenda for Sustainable Development,adopted in 2015,established the Sustainable Development Goals(SDGs)as a comprehensive framework to address global challenges through interconnected social,economic,and environmental targets.展开更多
China’s winter sports boom is expanding beyond its traditional northern heartlands,fueling a dynamic ice-snow economy and culture nationwide.This seasonal surge is driven by sustained investment and innovative develo...China’s winter sports boom is expanding beyond its traditional northern heartlands,fueling a dynamic ice-snow economy and culture nationwide.This seasonal surge is driven by sustained investment and innovative development models that are turning cold climates into hot economic opportunities.展开更多
China is carving out a distinctive development path which features urban-rural integration.This approach has not only yielded tangible results domestically but also drawn the attention of other countries.
To advance intelligent construction,standards must come first.The Ministry of Housing and Urban-Rural Development has issued the List for Replicable Experience and Practices for Developing Intelligent Construction fou...To advance intelligent construction,standards must come first.The Ministry of Housing and Urban-Rural Development has issued the List for Replicable Experience and Practices for Developing Intelligent Construction four times successively and the Technical Guidelines for Intelligent Construction(Trial).展开更多
China aims to build on its achievements of the past five years to accelerate rural revitalization during the 15th Five-Year Plan period.IN China,issues relating to agriculture,rural areas,and rural residents have alwa...China aims to build on its achievements of the past five years to accelerate rural revitalization during the 15th Five-Year Plan period.IN China,issues relating to agriculture,rural areas,and rural residents have always been a priority in national development.At its fourth plenary session held in October 2025,the 20th Central Committee of the Communist Party of China(CPC)once again emphasized the need to accelerate agricultural and rural modernization,and advance all-around rural revitalization over the next five years.展开更多
At the World Economic Forum Annual Meeting 2026 in Davos,China emerged as a steadfast advocate for multilateral cooperation and constructive dialogue,presenting a clear alternative to divisive rhetoric.CHINA’S role a...At the World Economic Forum Annual Meeting 2026 in Davos,China emerged as a steadfast advocate for multilateral cooperation and constructive dialogue,presenting a clear alternative to divisive rhetoric.CHINA’S role as a key player in shaping global development and trends stood out at the World Economic Forum(WEF)annual meeting 2026 in Davos,Switzerland.展开更多
The CPC Central Committee’s Recommendations for Formulating the 15th Five-Year Plan for National Economic and Social Development place rural revitalization as a priority within the overall framework of modernization,...The CPC Central Committee’s Recommendations for Formulating the 15th Five-Year Plan for National Economic and Social Development place rural revitalization as a priority within the overall framework of modernization,clearly stating that agricultural and rural modernization has a major bearing on Chinese modernization as a whole and the outcomes it delivers.展开更多
基金supported by the Shenyang City-School Joint Funding Project(No.2400022093)Liaoning Province Education Department Scientific Research Funding Project(No.LJKZ0777).
文摘In recent years,with the continuous development of biotechnology and medical science and technology,therapeutic antibodies,as new biologics,have shown great potential and have become a research hotspot in the fields of oncology,autoimmune diseases,cardiovascular and neuroscience.Therapeutic antibodies refer to drugs or therapeutic methods for the treatment of diseases with specificity,high affinity and high efficiency antibody molecules prepared by biotechnological means.In this paper,we will systematically review the types of therapeutic antibodies,research progress,problems in research and development,mechanisms of action,and challenges faced in clinical applications.
基金supported by grants from Simons Foundation (SFARI 479754),CIHR (PJT-180565)the Scottish Rite Charitable Foundation of Canada (to YL)funding from the Canada Research Chairs program。
文摘The mechanistic target of rapamycin(m TOR) is a serine/threonine kinase that plays a pivotal role in cellular growth, proliferation, survival, and metabolism. In the central nervous system(CNS), the mTOR pathway regulates diverse aspects of neural development and function. Genetic mutations within the m TOR pathway lead to severe neurodevelopmental disorders, collectively known as “mTORopathies”(Crino, 2020). Dysfunctions of m TOR, including both its hyperactivation and hypoactivation, have also been implicated in a wide spectrum of other neurodevelopmental and neurodegenerative conditions, highlighting its importance in CNS health.
基金Support by National Natural Science Foundation of China(22127802,22573091)the HY Action(62402010305)。
文摘Biomass-based hydrocarbon fuels,as one of the alternatives to traditional fossil fuels,have attracted considerable attention in the energy field due to their renewability and environmental benefits.This article provides a systematic review of recent research progress in the chemical synthesis of biomass-based hydrocarbon fuels.It outlines the conversion pathways using feedstocks such as lipids,terpenoids,cellulose/hemicellulose,and lignin.Depending on the feedstock,various products with distinct structural characteristics can be prepared through reactions such as cyclization,condensation,and catalytic hydrogenation.Throughout the synthesis process,three key factors play a critical role:efficient catalyst development,production process optimization,and computational-chemistry-based molecular design.Finally,the article discusses future perspectives for biomass-based hydrocarbon fuel synthesis research.
文摘First,statistics on the operational lines and mileage of urban rail transit in China are conducted.The results show that,as of Dec.31,2025,there were 60 cities with urban rail transit in operation nationwide,with a total operational mileage of approximately 12837.8 km(excluding the electronic guideway rubber-tired system,there were 57 cities,with a total operational mileage of 12651.6 km).The metro system dominates,while low-capacity systems exhibit a multi-modal development pattern.Subsequently,the characteristics of China′s urban rail transit industry development are analyzed,indicating that:(1)It should closely align with the theme of urban intensive development,promote quality improvement and efficiency enhancement of existing lines,and focus on the supporting role of initial passenger flow for new line construction,multi-network integration,and economic and financial sustainability.(2)Significant innovative achievements have been made in safety resilience,green and low-carbon development,intelligent construction,and digital transformation.Finally,development recommendations for the"15th Five-Year Plan"period are proposed:promoting cost reduction and efficiency improvement in the rail transit industry,enhancing the operational efficiency of existing networks,continuously exploring railway services for urban commuting,strengthening external exchanges,and driving the"going global"strategy of the urban rail transit industry.
文摘Innovation and Development Policy,简称“IDP”,中文名:《创新与发展政策(英文)》,是由中国科学院主管,中国科学院科技战略咨询研究院、中国科学学与科技政策研究会共同主办,国内外发行(ISSN:2096-5141,CN:10-1513/D)的英文国际期刊。目前期刊每年出版两期。已发表论文在期刊网站可以自由获取,http://idp-journal.casisd.cn/browse/al/al2019/。
文摘The United Nations Sustainable Development Goal(SDG) 2 aims to achieve Zero Hunger by 2030.However,global hunger and food insecurity have continued to rise at an alarming rate(UN 2023).Subtropical regions are home to more than 30% of the world's population,predominantly in developing countries where per capita farmland and food supply are only 40% of those in developed nations(FAO 2018).Meeting the Zero Hunger target amid ongoing population growth in these regions requires a substantial increase in agricultural production while minimizing soil degradation and adverse ecological impacts.This challenge is shared by many countries across South Asia,Africa,and Central and South America.
文摘Standards are the common language that consolidates global consensus and builds the most solid foundation for international partnerships.They are the cornerstone for global sustainable and high-quality development.Young students,with their active and vibrant minds,represent the future and hope of standardization.
文摘China-Zimbabwe collaboration is creating new opportunities for innovation and development of youth Zimbabwe’s development has long faced obstacles linked to Western economic sanctions,measures that many view as unjust or unlawful.Yet,despite these constraints,Zimbabwe remains a nation rich in natural resources and endowed with a highly educated population,with its youth standing out as a particularly dynamic force.
文摘The Outline of Women's Development in China(2021-2030)has proposed goals and supportive measures,to promote women's employment and entrepreneurship,and to guarantee equal rights and opportunities for women to participate in economic development.In the process of promoting high-quality economic development,China is upholding employment as a priority.
基金supported by the Royal Thai Government Scholarship in Science and Technology and the Faculty of Environment and Resource Studies,Mahidol University,Thailand(FERS,Mahidol University).
文摘Land degradation,coupled with climate change impacts,poses serious threats to global land health and human well-being.Participatory scenario planning(PSP)has become a key tool for exploring these interconnected challenges;however,its progress and effectiveness remain underexplored.This study reviews 46 papers,using PRISMA guidelines,to investigate how PSP supports sustainable land management and climate resilience.We document how PSP applications have evolved from a biophysical focus to one addressing broader environmental,societal,and economic challenges.Disparities in how participants engage across PSP phases document the need for more equitable and meaningful participation.Clustering future scenarios reveals the complex interconnections among ecological,social,and economic factors underpinning land management and climate resilience,underscoring the need for inclusive and integrated strategies.From the emerging trends,we identify opportunities to advance PSP implementation,including early engagement of decision-makers,balanced representation and equitable power dynamics,meaningful participation,cross-disciplinary collaboration,integration of human-nature relationships,and regular revision of future pathways.Overall,our review highlights PSP’s potential to co-create inclusive,equitable scenarios and actionable pathways towards sustainable and resilient land use futures.
文摘Discussions on Chinese modernization are offering African countries both conceptual inspiration and practical references as they explore their own sustainable development paths.
文摘In the lush heart of Uganda’s Busoga sub-region,Isaac Imaka is charting a new course for rural development.After seven years in national media,he left the newsroom and stepped into the soil.The former reporter with the Daily Monitor was driven by the belief that communities like his in Jinja North deserved more than chronic poverty and hand-to-mouth survival.
文摘Agricultural development is regarded as the most important foundation of China’s modernisation.According to the Recommendations of the CPC Central Committee for Formulating the 15th Five-Year Plan for National Economic and Social Development(2026–2030),issues related to agriculture,rural areas and rural residents should be given top priority.In the coming years,China will promote coordinated urban and rural development,continue to consolidate and expand the achievements of poverty alleviation,ensure basic modern living conditions in rural areas,and accelerate progress in building a strong agricultural sector.
文摘1.Background The United Nations(UN)2030 Agenda for Sustainable Development,adopted in 2015,established the Sustainable Development Goals(SDGs)as a comprehensive framework to address global challenges through interconnected social,economic,and environmental targets.
文摘China’s winter sports boom is expanding beyond its traditional northern heartlands,fueling a dynamic ice-snow economy and culture nationwide.This seasonal surge is driven by sustained investment and innovative development models that are turning cold climates into hot economic opportunities.
文摘China is carving out a distinctive development path which features urban-rural integration.This approach has not only yielded tangible results domestically but also drawn the attention of other countries.
文摘To advance intelligent construction,standards must come first.The Ministry of Housing and Urban-Rural Development has issued the List for Replicable Experience and Practices for Developing Intelligent Construction four times successively and the Technical Guidelines for Intelligent Construction(Trial).
文摘China aims to build on its achievements of the past five years to accelerate rural revitalization during the 15th Five-Year Plan period.IN China,issues relating to agriculture,rural areas,and rural residents have always been a priority in national development.At its fourth plenary session held in October 2025,the 20th Central Committee of the Communist Party of China(CPC)once again emphasized the need to accelerate agricultural and rural modernization,and advance all-around rural revitalization over the next five years.
文摘At the World Economic Forum Annual Meeting 2026 in Davos,China emerged as a steadfast advocate for multilateral cooperation and constructive dialogue,presenting a clear alternative to divisive rhetoric.CHINA’S role as a key player in shaping global development and trends stood out at the World Economic Forum(WEF)annual meeting 2026 in Davos,Switzerland.
文摘The CPC Central Committee’s Recommendations for Formulating the 15th Five-Year Plan for National Economic and Social Development place rural revitalization as a priority within the overall framework of modernization,clearly stating that agricultural and rural modernization has a major bearing on Chinese modernization as a whole and the outcomes it delivers.
