The complexity of living environment system demands higher requirements for the sensitivity and selectivity of the probe.Therefore,it is of great importance to develop a universal strategy for highperformance probe op...The complexity of living environment system demands higher requirements for the sensitivity and selectivity of the probe.Therefore,it is of great importance to develop a universal strategy for highperformance probe optimization.Herein,we propose a novel“Enrichment-enhanced Detection”strategy and use carbon dots-dopamine detection system as a representative model to evaluate its feasibility.The composite probe carbon dots (CDs)-encapsulated in glycol-chitosan (GC)(i.e.,CDs@GC) was obtained by simply mixing GC and CDs through noncovalent interactions,including electrostatic interactions and hydrogen bonding.Dopamine (DA) could be detected through internal filter effect (IFE)-induced quenching of CDs.In the case of CDs@GC,noncovalent interactions (electrostatic interactions) between GC and the formed quinone (oxide of DA) could selectively extract and enrich the local concentration of DA,thus effectively improving the sensitivity and selectivity of the sensing system.The nanosensor had a low detection limit of 3.7 nmol/L,which was a 12-fold sensitivity improvement compared to the bare CDs probes with similar fluorescent profiles,proving the feasibility of the“Enrichment-enhanced Detection”strategy.Further,to examine this theory in real case,we designed a highly portable sensing platform to realize visual determination of DA.Overall,our work introduces a new strategy for accurately detecting DA and provides valuable insights for the universal design and optimization of superior nanoprobes.展开更多
Human-machine interfaces(HMI)are of paramount importance as they serve as essential conduits between humans and the digital realm.However,contemporary designs suffer from the following issues:large number of electrode...Human-machine interfaces(HMI)are of paramount importance as they serve as essential conduits between humans and the digital realm.However,contemporary designs suffer from the following issues:large number of electrodes,complex wiring,redundant data,and high power consumption.This work proposes a body-coupled minimalist human-machine interface for multifunctional touch detection(BM-HMI).The configuration of gradient resistive elements in the S-shape,in conjunction with a detection strategy founded upon the ratio of relative signal amplitudes,facilitates the effective detection of signals across a range of touch and sliding operations utilizing a mere two sensing electrodes.The experimental results demonstrate that the BM-HMI requires no battery,has remarkable stability(over 400,000 cycles),structural simplicity,rapid response time(approximately 5 ms),ultra-low detection threshold(below 0.04 N),robustness,and high scalability.This work presents a novel concept,demonstrating considerable potential for application in smart wearable devices,mixed reality systems,and ubiquitous sensing terminals.展开更多
Room-temperature(RT)terahertz(THz)detection finds widespread applications in security inspection,communication,biomedical imaging,and scientific research.However,the state-of-the-art detection strategies are still lim...Room-temperature(RT)terahertz(THz)detection finds widespread applications in security inspection,communication,biomedical imaging,and scientific research.However,the state-of-the-art detection strategies are still limited by issues such as low sensitivity,narrow response range,slow response speed,complex fabrication techniques,and difficulties in scaling up to large arrays.Here,we present a high-sensitivity,broadband-response,and high-speed RT THz detection strategy by utilizing a deep subwavelength metal–semiconductor–metal(MSM)structure.The spontaneously formed 2-dimensional electron gas(2DEG)at the CdTe/PbTe interface provides a superior transport channel characterized by high carrier concentration,low scattering,and high mobility.The synergy of the electromagnetic induced well effect formed in the MSM structure,and the efficient and rapid transport capabilities of the 2DEG channel give rise to an impressive performance improvement.The proposed 2DEG photodetector exhibits a broad frequency range from 22 to 519 GHz,an ultralow noise equivalent power of 3.0×10^(−14)W Hz^(−1/2)at 166 GHz,and a short response time of 6.7μs.This work provides an effective route for the development of high-performance RT THz detection strategies,paving the way for enhanced THz technology applications.展开更多
Mercury ion(Hg^(2+)),known as one of the highly toxic and soluble heavy metal ions,is causing serious environmental pollution and irreversible damage to the health.It is urgent to develop some rapid and ultrasensitive...Mercury ion(Hg^(2+)),known as one of the highly toxic and soluble heavy metal ions,is causing serious environmental pollution and irreversible damage to the health.It is urgent to develop some rapid and ultrasensitive methods for detecting trace mercury ions in the environment especially drink water.Surface-enhanced Raman scattering(SERS)is considered as a novel and powerful optical analysis technique since it has the significant advantages of ultra-sensitivity and high specificity.In recent years,the SERS technique and its application in the detection of Hg^(2+)have become more prevalent and compelling.This review provides an overall survey of the development of SERS-based Hg^(2+)detections and presents a summary relating to the basic principles,detection strategies,recent advances and current challenges of SERS for Hg^(2+)detections.展开更多
Introduction:Myopia prevalence among Chinese children and adolescents remains persistently high,with an alarming trend toward earlier onset.Understanding the correlation between ocular biometric parameters and myopia ...Introduction:Myopia prevalence among Chinese children and adolescents remains persistently high,with an alarming trend toward earlier onset.Understanding the correlation between ocular biometric parameters and myopia development provides essential insights into underlying mechanisms.This study evaluated the associations between axial length(AL),axial length-to-corneal radius ratio(AL/CR),and spherical equivalent refraction(SER)across different age groups to inform early detection strategies and myopia management protocols.Methods:Students aged 5–18 years were recruited from 10 provincial-level administrative divisions across China between November 2020 and July 2024 using hierarchical clustering and probability proportionate to size(PPS)sampling methods.The final analytical sample comprised 60,270 participants.Trained professionals conducted cycloplegic optometry and measured ocular biometric parameters.Data underwent weighted analysis using nonparametric tests and receiver operating characteristic(ROC)curve analysis to establish predictive thresholds for myopia detection.Results:Overall myopia prevalence reached 29.24%,demonstrating a progressive increase across school grades.Median SER values exhibited increasingly negative trends with advancing educational levels.Correlation analysis revealed that AL/CR demonstrated stronger associations with SER(R=−0.750,P<0.001)compared to AL alone(R=−0.657,P<0.001).ROC analysis confirmed superior predictive accuracy for AL/CR over AL across all age groups,with area under the curve values approaching or exceeding 0.88 among upper-grade students.Conclusions:Both AL/CR and AL serve as effective indicators for identifying children at elevated myopia risk during early childhood.Routine monitoring of AL and AL/CR within school health programs can facilitate early intervention strategies and myopia control measures,particularly in regions with limited access to cycloplegic optometry services.展开更多
基金the financial support from the National Natural Science Foundation of China(No.21904007)the Fundamental Research Funds for the Central Universities(China,No.2412022QD008)+1 种基金the Jilin Provincial Department of Education(China),the Key Laboratory of Nanobiosensing and Nanobioanalysis at Universities of Jilin Province(China)the Analysis and Testing Center of Northeast Normal University(China)。
文摘The complexity of living environment system demands higher requirements for the sensitivity and selectivity of the probe.Therefore,it is of great importance to develop a universal strategy for highperformance probe optimization.Herein,we propose a novel“Enrichment-enhanced Detection”strategy and use carbon dots-dopamine detection system as a representative model to evaluate its feasibility.The composite probe carbon dots (CDs)-encapsulated in glycol-chitosan (GC)(i.e.,CDs@GC) was obtained by simply mixing GC and CDs through noncovalent interactions,including electrostatic interactions and hydrogen bonding.Dopamine (DA) could be detected through internal filter effect (IFE)-induced quenching of CDs.In the case of CDs@GC,noncovalent interactions (electrostatic interactions) between GC and the formed quinone (oxide of DA) could selectively extract and enrich the local concentration of DA,thus effectively improving the sensitivity and selectivity of the sensing system.The nanosensor had a low detection limit of 3.7 nmol/L,which was a 12-fold sensitivity improvement compared to the bare CDs probes with similar fluorescent profiles,proving the feasibility of the“Enrichment-enhanced Detection”strategy.Further,to examine this theory in real case,we designed a highly portable sensing platform to realize visual determination of DA.Overall,our work introduces a new strategy for accurately detecting DA and provides valuable insights for the universal design and optimization of superior nanoprobes.
基金supported by the National Natural Science Foundation of China(No.52505071,No.52475071,No.52475072,No.52305308)the Yanzhao’s Young Scientist Project(2023203258)+5 种基金the Hebei Natural Science Foundation(E2022203002,and E2024203067)the Funded by Science Research Project of Hebei Education Department(QN2025183)the Shijiazhuang Science and Technology Planning Project(241790727A)the Opening Project of the Key Laboratory of Bionic Engineering(Ministry of Education,Jilin UniversityGrant Number KF2023003)The Fundamental Innovative Research Development Project of Yanshan University(2024LGQN008).
文摘Human-machine interfaces(HMI)are of paramount importance as they serve as essential conduits between humans and the digital realm.However,contemporary designs suffer from the following issues:large number of electrodes,complex wiring,redundant data,and high power consumption.This work proposes a body-coupled minimalist human-machine interface for multifunctional touch detection(BM-HMI).The configuration of gradient resistive elements in the S-shape,in conjunction with a detection strategy founded upon the ratio of relative signal amplitudes,facilitates the effective detection of signals across a range of touch and sliding operations utilizing a mere two sensing electrodes.The experimental results demonstrate that the BM-HMI requires no battery,has remarkable stability(over 400,000 cycles),structural simplicity,rapid response time(approximately 5 ms),ultra-low detection threshold(below 0.04 N),robustness,and high scalability.This work presents a novel concept,demonstrating considerable potential for application in smart wearable devices,mixed reality systems,and ubiquitous sensing terminals.
基金supported by the National Natural Science Foundation of China(11933006,61805060,U2141240,and 62175045)National Key Research and Development Project of China(2023YFB2806700)+5 种基金Zhejiang Provincial Natural Science Foundation of China(LGF21F050001)Hangzhou Science and Technology Bureau of Zhejiang Province(TD2020002)Hangzhou Key Research and Development Program(2024SZD1A39)Research Funds of Hangzhou Institute for Advanced Study(B02006C019019 and 2022ZZ01007)Zhejiang Provincial Natural Science Foundation of China(no.LD25F040001)Hangzhou Joint Fund of the Zhejiang Provincial Natural Science Foundation of China(no.LHZQN25F050001).
文摘Room-temperature(RT)terahertz(THz)detection finds widespread applications in security inspection,communication,biomedical imaging,and scientific research.However,the state-of-the-art detection strategies are still limited by issues such as low sensitivity,narrow response range,slow response speed,complex fabrication techniques,and difficulties in scaling up to large arrays.Here,we present a high-sensitivity,broadband-response,and high-speed RT THz detection strategy by utilizing a deep subwavelength metal–semiconductor–metal(MSM)structure.The spontaneously formed 2-dimensional electron gas(2DEG)at the CdTe/PbTe interface provides a superior transport channel characterized by high carrier concentration,low scattering,and high mobility.The synergy of the electromagnetic induced well effect formed in the MSM structure,and the efficient and rapid transport capabilities of the 2DEG channel give rise to an impressive performance improvement.The proposed 2DEG photodetector exhibits a broad frequency range from 22 to 519 GHz,an ultralow noise equivalent power of 3.0×10^(−14)W Hz^(−1/2)at 166 GHz,and a short response time of 6.7μs.This work provides an effective route for the development of high-performance RT THz detection strategies,paving the way for enhanced THz technology applications.
基金the National Basic Research Program of China(2012CB933301)the National Natural Science Foundation of China(21475064)+4 种基金the Natural Science Foundation of Jiangsu Province of China(BM2012010)the Natural Science Fund for Colleges and Universities in Jiangsu Province(13KJB140009)the Sci-tech Support Plan of Jiangsu Province(BE2014719)the Research Innovation Program for College Graduates of Jiangsu Province(SJZZ15_0107)the Priority Academic Program Development of Jiangsu Higher Education Institutions(YX03001)
文摘Mercury ion(Hg^(2+)),known as one of the highly toxic and soluble heavy metal ions,is causing serious environmental pollution and irreversible damage to the health.It is urgent to develop some rapid and ultrasensitive methods for detecting trace mercury ions in the environment especially drink water.Surface-enhanced Raman scattering(SERS)is considered as a novel and powerful optical analysis technique since it has the significant advantages of ultra-sensitivity and high specificity.In recent years,the SERS technique and its application in the detection of Hg^(2+)have become more prevalent and compelling.This review provides an overall survey of the development of SERS-based Hg^(2+)detections and presents a summary relating to the basic principles,detection strategies,recent advances and current challenges of SERS for Hg^(2+)detections.
基金the Ministry of Science and Technology of the People’s Republic of China,National Key Research and Development Program of China(2021YFC2702102)the Beijing Municipal Health Commission High-level Public Health Technical Talent Construction Project(Leading Talent-01-09).
文摘Introduction:Myopia prevalence among Chinese children and adolescents remains persistently high,with an alarming trend toward earlier onset.Understanding the correlation between ocular biometric parameters and myopia development provides essential insights into underlying mechanisms.This study evaluated the associations between axial length(AL),axial length-to-corneal radius ratio(AL/CR),and spherical equivalent refraction(SER)across different age groups to inform early detection strategies and myopia management protocols.Methods:Students aged 5–18 years were recruited from 10 provincial-level administrative divisions across China between November 2020 and July 2024 using hierarchical clustering and probability proportionate to size(PPS)sampling methods.The final analytical sample comprised 60,270 participants.Trained professionals conducted cycloplegic optometry and measured ocular biometric parameters.Data underwent weighted analysis using nonparametric tests and receiver operating characteristic(ROC)curve analysis to establish predictive thresholds for myopia detection.Results:Overall myopia prevalence reached 29.24%,demonstrating a progressive increase across school grades.Median SER values exhibited increasingly negative trends with advancing educational levels.Correlation analysis revealed that AL/CR demonstrated stronger associations with SER(R=−0.750,P<0.001)compared to AL alone(R=−0.657,P<0.001).ROC analysis confirmed superior predictive accuracy for AL/CR over AL across all age groups,with area under the curve values approaching or exceeding 0.88 among upper-grade students.Conclusions:Both AL/CR and AL serve as effective indicators for identifying children at elevated myopia risk during early childhood.Routine monitoring of AL and AL/CR within school health programs can facilitate early intervention strategies and myopia control measures,particularly in regions with limited access to cycloplegic optometry services.
