Microneedle electrochemical biosensors have emerged as a crucial technology for non-invasive biomarker detection,offering minimally invasive and real-time monitoring capabilities.These biosensors utilize a microneedle...Microneedle electrochemical biosensors have emerged as a crucial technology for non-invasive biomarker detection,offering minimally invasive and real-time monitoring capabilities.These biosensors utilize a microneedle array to extract interstitial fluid,and integrate biological recognition elements(e.g.,enzymes,antibodies)and electrochemical signal converters(e.g.,current,resistance)to enable rapid and sensitive detection of various biomarkers like blood glucose,lactic acid,and electrolytes.Despite the commercialization of this technology in continuous blood glucose monitoring,challenges persist,including the need to balance needle length and mechanical strength,ensure long-term stability against biological contamination and enzyme inactivation,and optimize large-scale manufacturing processes.Future advancements are anticipated through interdisciplinary collaborations,leveraging artificial intelligence for data analysis and exploring biodegradable materials,to facilitate the transition of microneedle electrochemical sensors from research settings to clinical use and advance the field of personalized medicine.This review examines the historical development,design,manufacturing processes,sensing mechanisms,biomarker detection capabilities,and integration potential of microneedle electrochemical biosensors,while also addressing their application prospects and technical hurdles.展开更多
In recent years,RS and GIS technologies have played an increasingly important role in various aspects of rainfall induced landslide research.In order to systematically understand their application situation,this paper...In recent years,RS and GIS technologies have played an increasingly important role in various aspects of rainfall induced landslide research.In order to systematically understand their application situation,this paper extensively used various visualization analysis technologies for in-depth analysis of 1,161 documents collected by the WOS data platform in the past 27 years by combining quantitative and qualitative methods.Then,this article focuses on sub domain analysis from four aspects:landslide detection and monitoring,prediction models,sensitivity mapping,and risk assessment.The study found that the number of literature in thisfield has steadily increased and is expected to continue to rise.This literature review has attracted widespread attention from the academic community,but it challenging to meet research needs.Frequent and effective cooperationis between countries,institutions,and authors is very beneficial for promoting progress in thisfield.The future development direction is a new intelligent hybrid model that integrates multiple research methods.This study can provide researchers in thisfield with the core research force,hot topic evolution,and future development trends of future rainfall-induced landslides and contribute to landslide prevention and control decision-making and achieving the United Nations’sustainable development goals.展开更多
基金the National Key Research and Development Program of China(2023YFC2507600)National Natural Science Foundation of China(No.22175060).
文摘Microneedle electrochemical biosensors have emerged as a crucial technology for non-invasive biomarker detection,offering minimally invasive and real-time monitoring capabilities.These biosensors utilize a microneedle array to extract interstitial fluid,and integrate biological recognition elements(e.g.,enzymes,antibodies)and electrochemical signal converters(e.g.,current,resistance)to enable rapid and sensitive detection of various biomarkers like blood glucose,lactic acid,and electrolytes.Despite the commercialization of this technology in continuous blood glucose monitoring,challenges persist,including the need to balance needle length and mechanical strength,ensure long-term stability against biological contamination and enzyme inactivation,and optimize large-scale manufacturing processes.Future advancements are anticipated through interdisciplinary collaborations,leveraging artificial intelligence for data analysis and exploring biodegradable materials,to facilitate the transition of microneedle electrochemical sensors from research settings to clinical use and advance the field of personalized medicine.This review examines the historical development,design,manufacturing processes,sensing mechanisms,biomarker detection capabilities,and integration potential of microneedle electrochemical biosensors,while also addressing their application prospects and technical hurdles.
基金supported by the National Key R&D Program of China(2019YFC1510700)the Sichuan Science and Technology Program(2023Y FS0380,2023YFS0377,2023NSFSC1989,2022YFS0539).
文摘In recent years,RS and GIS technologies have played an increasingly important role in various aspects of rainfall induced landslide research.In order to systematically understand their application situation,this paper extensively used various visualization analysis technologies for in-depth analysis of 1,161 documents collected by the WOS data platform in the past 27 years by combining quantitative and qualitative methods.Then,this article focuses on sub domain analysis from four aspects:landslide detection and monitoring,prediction models,sensitivity mapping,and risk assessment.The study found that the number of literature in thisfield has steadily increased and is expected to continue to rise.This literature review has attracted widespread attention from the academic community,but it challenging to meet research needs.Frequent and effective cooperationis between countries,institutions,and authors is very beneficial for promoting progress in thisfield.The future development direction is a new intelligent hybrid model that integrates multiple research methods.This study can provide researchers in thisfield with the core research force,hot topic evolution,and future development trends of future rainfall-induced landslides and contribute to landslide prevention and control decision-making and achieving the United Nations’sustainable development goals.
