The Edikan Mine,which consists of Fobinso and Esuajah gold deposits,lies within the Asankrangwa Gold Belt of the Birimian Supergroup in the Kumasi Basin.The metasedimentary rocks in the Basins and the faulted metavolc...The Edikan Mine,which consists of Fobinso and Esuajah gold deposits,lies within the Asankrangwa Gold Belt of the Birimian Supergroup in the Kumasi Basin.The metasedimentary rocks in the Basins and the faulted metavolcanic rocks in the Belts that make up the Birimian Supergroup were intruded by granitoids during the Eburnean Orogeny.This research aims to classify granitoids in the Edikan Mine and ascertain the petrogenetic and geochemical characteristics of some auriferous granitoids in the wider Kumasi Basin,Ghana,to understand the implications for geodynamic settings.A multi-methods approach involving field studies,petrographic studies,and whole-rock geochemical analysis was used to achieve the goal of the study.Petrographic studies revealed a relatively high abundance of plagioclase and a low percentage of K-feldspars(anorthoclase and orthoclase)in the Fobinso samples,suggesting that the samples are granodioritic in nature,while the Esuajah samples showed relatively low plagioclase abundance and a high percentage in K-feldspars,indicating that they are granitic.The granitoids from the study areas are co-magmatic.The granitoids in Esuajah and Fobinso are generally enriched in large ion lithophile elements and light rare earth elements than high field strength elements,middle rare earth elements,and heavy rare earth elements,indicating mixing with crustal sources during the evolution of the granitoids.The granitoids were tectonically formed in a syn-collisional+VAG setting,which implies that they were formed in the subduction zone setting.Fobinso granodiorites showed S-type signatures with evidence of extensive crustal contamination,while the Esuajah granites showed I-type signatures with little or no crustal contamination and are peraluminous.Gold mineralization in the study area is structurally and lithologically controlled with shear zones,faulting,and veining as the principal structures controlling the mineralization.The late-stage vein,V3,in the Edikan Mine is characterized by a low vein angle and is mineralized.展开更多
Vascular endothelial growth factor and its mimic peptide KLTWQELYQLKYKGI(QK)are widely used as the most potent angiogenic factors for the treatment of multiple ischemic diseases.However,conventional topical drug deliv...Vascular endothelial growth factor and its mimic peptide KLTWQELYQLKYKGI(QK)are widely used as the most potent angiogenic factors for the treatment of multiple ischemic diseases.However,conventional topical drug delivery often results in a burst release of the drug,leading to transient retention(inefficacy)and undesirable diffusion(toxicity)in vivo.Therefore,a drug delivery system that responds to changes in the microenvironment of tissue regeneration and controls vascular endothelial growth factor release is crucial to improve the treatment of ischemic stroke.Matrix metalloproteinase-2(MMP-2)is gradually upregulated after cerebral ischemia.Herein,vascular endothelial growth factor mimic peptide QK was self-assembled with MMP-2-cleaved peptide PLGLAG(TIMP)and customizable peptide amphiphilic(PA)molecules to construct nanofiber hydrogel PA-TIMP-QK.PA-TIMP-QK was found to control the delivery of QK by MMP-2 upregulation after cerebral ischemia/reperfusion and had a similar biological activity with vascular endothelial growth factor in vitro.The results indicated that PA-TIMP-QK promoted neuronal survival,restored local blood circulation,reduced blood-brain barrier permeability,and restored motor function.These findings suggest that the self-assembling nanofiber hydrogel PA-TIMP-QK may provide an intelligent drug delivery system that responds to the microenvironment and promotes regeneration and repair after cerebral ischemia/reperfusion injury.展开更多
The application of generative artificial intelligence(GAI)in the judicial domain represents an innovative approach to achieving digital justice.GAI’s functionalities are primarily exhibited in the enhancement of judi...The application of generative artificial intelligence(GAI)in the judicial domain represents an innovative approach to achieving digital justice.GAI’s functionalities are primarily exhibited in the enhancement of judicial efficiency,improving the accuracy and fairness of adjudications,promoting the uniform application of the law,and enhancing transparency and engagement in judicial processes.However,these advancements are accompanied by potential risks and challenges in technology,adjudication,and ethics.It is thus essential to strengthen privacy protection during the processing and transmission of data,ensure data security and confidentiality,and establish and refine clear legal norms regarding the roles,responsibilities,and legal obligations of GAI in judicial settings.In addition,ethical guidelines that delineate the behavioral boundaries and value orientations of GAI need to be formulated.Collectively,these elements can form a trinary model of technical controls,legal norms,and ethical constraints,to facilitate the modernization and intelligent development of the judicial system.展开更多
Identifying key acupuncture elements is essential for optimizing sham acupuncture controls.Based on the characteristics and current state of acupuncture therapy,this paper categorizes key acupuncture elements into typ...Identifying key acupuncture elements is essential for optimizing sham acupuncture controls.Based on the characteristics and current state of acupuncture therapy,this paper categorizes key acupuncture elements into types and contents.Taking the former as a clue,it examines the current understanding of key acupuncture elements and underscores the need for further refinement to ensure that sham acupuncture controls more closely approximate physiological inertness.Additionally,it explores strategies and methodologies for advancing the understanding of key acupuncture elements from both the type and content perspectives.Key acupuncture elements should expand the number of included element types.Elements such as acupuncture needles,point selection,point combination,needle insertion,needle manipulation,and needle withdrawal should all be included,and they should be reported in a standardized manner in the trials.Regarding element content,improvements should be made in three key areas to enhance selection accuracy:1.Strengthening the comprehensiveness of relevant theoretical frameworks.2.Emphasizing the role of Traditional Chinese Medicine(TCM)diagnosis and acupoint palpation methods in trial application and reporting.3.Continuously investigating the mechanisms underlying both the specific efficacy and the placebo efficacy of acupuncture.展开更多
Aiming to solve the steering instability and hysteresis of agricultural robots in the process of movement,a fusion PID control method of particle swarm optimization(PSO)and genetic algorithm(GA)was proposed.The fusion...Aiming to solve the steering instability and hysteresis of agricultural robots in the process of movement,a fusion PID control method of particle swarm optimization(PSO)and genetic algorithm(GA)was proposed.The fusion algorithm took advantage of the fast optimization ability of PSO to optimize the population screening link of GA.The Simulink simulation results showed that the convergence of the fitness function of the fusion algorithm was accelerated,the system response adjustment time was reduced,and the overshoot was almost zero.Then the algorithm was applied to the steering test of agricultural robot in various scenes.After modeling the steering system of agricultural robot,the steering test results in the unloaded suspended state showed that the PID control based on fusion algorithm reduced the rise time,response adjustment time and overshoot of the system,and improved the response speed and stability of the system,compared with the artificial trial and error PID control and the PID control based on GA.The actual road steering test results showed that the PID control response rise time based on the fusion algorithm was the shortest,about 4.43 s.When the target pulse number was set to 100,the actual mean value in the steady-state regulation stage was about 102.9,which was the closest to the target value among the three control methods,and the overshoot was reduced at the same time.The steering test results under various scene states showed that the PID control based on the proposed fusion algorithm had good anti-interference ability,it can adapt to the changes of environment and load and improve the performance of the control system.It was effective in the steering control of agricultural robot.This method can provide a reference for the precise steering control of other robots.展开更多
In this paper,we consider the maximal positive definite solution of the nonlinear matrix equation.By using the idea of Algorithm 2.1 in ZHANG(2013),a new inversion-free method with a stepsize parameter is proposed to ...In this paper,we consider the maximal positive definite solution of the nonlinear matrix equation.By using the idea of Algorithm 2.1 in ZHANG(2013),a new inversion-free method with a stepsize parameter is proposed to obtain the maximal positive definite solution of nonlinear matrix equation X+A^(*)X|^(-α)A=Q with the case 0<α≤1.Based on this method,a new iterative algorithm is developed,and its convergence proof is given.Finally,two numerical examples are provided to show the effectiveness of the proposed method.展开更多
As an important resource in data link,time slots should be strategically allocated to enhance transmission efficiency and resist eavesdropping,especially considering the tremendous increase in the number of nodes and ...As an important resource in data link,time slots should be strategically allocated to enhance transmission efficiency and resist eavesdropping,especially considering the tremendous increase in the number of nodes and diverse communication needs.It is crucial to design control sequences with robust randomness and conflict-freeness to properly address differentiated access control in data link.In this paper,we propose a hierarchical access control scheme based on control sequences to achieve high utilization of time slots and differentiated access control.A theoretical bound of the hierarchical control sequence set is derived to characterize the constraints on the parameters of the sequence set.Moreover,two classes of optimal hierarchical control sequence sets satisfying the theoretical bound are constructed,both of which enable the scheme to achieve maximum utilization of time slots.Compared with the fixed time slot allocation scheme,our scheme reduces the symbol error rate by up to 9%,which indicates a significant improvement in anti-interference and eavesdropping capabilities.展开更多
In this paper,we define for the trace operator,the solution of certain models of vibrating plates standards with initial data in a strategic region spaces of weak regularities.Indeed,we know that the notion of regiona...In this paper,we define for the trace operator,the solution of certain models of vibrating plates standards with initial data in a strategic region spaces of weak regularities.Indeed,we know that the notion of regional controllability is more adapted to systems described by dynamic systems.Regional controllability results in a strategic area were established for vibrating plates by the Hilbertian Uniqueness Method.展开更多
Molten salt reactors,being the only reactor type among Generation Ⅳ advanced nuclear reactors that utilize liquid fuels,offer inherent safety,high-temperature,and low-pressure operation,as well as the capability for ...Molten salt reactors,being the only reactor type among Generation Ⅳ advanced nuclear reactors that utilize liquid fuels,offer inherent safety,high-temperature,and low-pressure operation,as well as the capability for online fuel reprocessing.However,the fuel-salt flow results in the decay of delayed neutron precursors(DNPs)outside the core,causing fluctuations in the effective delayed neutron fraction and consequently impacting the reactor reactivity.Particularly in accident scenarios—such as a combined pump shutdown and the inability to rapidly scram the reactor—the sole reliance on negative temperature feedback may cause a significant increase in core temperature,posing a threat to reactor safety.To address these problems,this paper introduces an innovative design for a passive fluid-driven suspended control rod(SCR)to dynamically compensate for reactivity fluctuations caused by DNPs flowing with the fuel.The control rod operates passively by leveraging the combined effects of gravity,buoyancy,and fluid dynamic forces,thereby eliminating the need for an external drive mechanism and enabling direct integration within the active region of the core.Using a 150 MWt thorium-based molten salt reactor as the reference design,we develop a mathematical model to systematically analyze the effects of key parameters—including the geometric dimensions and density of the SCR—on its performance.We examine its motion characteristics under different core flow conditions and assess its feasibility for the dynamic compensation of reactivity changes caused by fuel flow.The results of this study demonstrate that the SCR can effectively counteract reactivity fluctuations induced by fuel flow within molten salt reactors.A sensitivity analysis reveals that the SCR’s average density exerts a profound impact on its start-up flow threshold,channel flow rate,resistance to fuel density fluctuations,and response characteristics.This underscores the critical need to optimize this parameter.Moreover,by judiciously selecting the SCR’s length,number of deployed units,and the placement we can achieve the necessary reactivity control while maintaining a favorable balance between neutron economy and heat transfer performance.Ultimately,this paper provides an innovative solution for the passive reactivity control in molten salt reactors,offering significant potential for practical engineering applications.展开更多
Modern power systems increasingly depend on interconnected microgrids to enhance reliability and renewable energy utilization.However,the high penetration of intermittent renewable sources often causes frequency devia...Modern power systems increasingly depend on interconnected microgrids to enhance reliability and renewable energy utilization.However,the high penetration of intermittent renewable sources often causes frequency deviations,voltage fluctuations,and poor reactive power coordination,posing serious challenges to grid stability.Conventional Interconnection FlowControllers(IFCs)primarily regulate active power flowand fail to effectively handle dynamic frequency variations or reactive power sharing in multi-microgrid networks.To overcome these limitations,this study proposes an enhanced Interconnection Flow Controller(e-IFC)that integrates frequency response balancing and an Interconnection Reactive Power Flow Controller(IRFC)within a unified adaptive control structure.The proposed e-IFC is implemented and analyzed in DIgSILENT PowerFactory to evaluate its performance under various grid disturbances,including frequency drops,load changes,and reactive power fluctuations.Simulation results reveal that the e-IFC achieves 27.4% higher active power sharing accuracy,19.6% lower reactive power deviation,and 18.2% improved frequency stability compared to the conventional IFC.The adaptive controller ensures seamless transitions between grid-connected and islanded modes and maintains stable operation even under communication delays and data noise.Overall,the proposed e-IFCsignificantly enhances active-reactive power coordination and dynamic stability in renewable-integrated multi-microgrid systems.Future research will focus on coupling the e-IFC with tertiary-level optimization frameworks and conducting hardware-in-the-loop validation to enable its application in large-scale smart microgrid environments.展开更多
Conventional multilevel inverters often suffer from high harmonic distortion and increased design complexity due to the need for numerous power semiconductor components,particularly at elevated voltage levels.Addressi...Conventional multilevel inverters often suffer from high harmonic distortion and increased design complexity due to the need for numerous power semiconductor components,particularly at elevated voltage levels.Addressing these shortcomings,thiswork presents a robust 15-level PackedUCell(PUC)inverter topology designed for renewable energy and grid-connected applications.The proposed systemintegrates a sensor less proportional-resonant(PR)controller with an advanced carrier-based pulse width modulation scheme.This approach efficiently balances capacitor voltage,minimizes steady-state error,and strongly suppresses both zero and third-order harmonics resulting in reduced total harmonic distortion and enhanced voltage regulation.Additionally,a novel switching algorithm simplifies the design and implementation,further lowering voltage stress across switches.Extensive simulation results validate the performance under various resistive and resistive-inductive load conditions,demonstrating compliance with IEEE-519 THD standards and robust operation under dynamic changes.The proposed sensorless PR-controlled 15-PUC inverter thus offers a compelling,cost-effective solution for efficient power conversion in next-generation renewable energy systems.展开更多
To address the issue of instability or even imbalance in the orientation and attitude control of quadrotor unmanned aerial vehicles(QUAVs)under random disturbances,this paper proposes a distributed antidisturbance dat...To address the issue of instability or even imbalance in the orientation and attitude control of quadrotor unmanned aerial vehicles(QUAVs)under random disturbances,this paper proposes a distributed antidisturbance data-driven event-triggered fusion control method,which achieves efficient fault diagnosis while suppressing random disturbances and mitigating communication conflicts within the QUAV swarm.First,the impact of random disturbances on the UAV swarm is analyzed,and a model for orientation and attitude control of QUAVs under stochastic perturbations is established,with the disturbance gain threshold determined.Second,a fault diagnosis system based on a high-gain observer is designed,constructing a fault gain criterion by integrating orientation and attitude information from QUAVs.Subsequently,a model-free dynamic linearization-based data modeling(MFDLDM)framework is developed using model-free adaptive control,which efficiently fits the nonlinear control model of the QUAV swarm while reducing temporal constraints on control data.On this basis,this paper constructs a distributed data-driven event-triggered controller based on the staggered communication mechanism,which consists of an equivalent QUAV controller and an event-triggered controller,and is able to reduce the communication conflicts while suppressing the influence of random interference.Finally,by incorporating random disturbances into the controller,comparative experiments and physical validations are conducted on the QUAV platforms,fully demonstrating the strong adaptability and robustness of the proposed distributed event-triggered fault-tolerant control system.展开更多
The focal adhesion(FA)is the structural basis of the cell-extracellular matrix crosstalk and plays important roles in control of organ formation and function.Here we show that expression of FA protein vinculin is dram...The focal adhesion(FA)is the structural basis of the cell-extracellular matrix crosstalk and plays important roles in control of organ formation and function.Here we show that expression of FA protein vinculin is dramatically reduced in osteocytes in patients with aging-related osteoporosis.Vinculin loss severely impaired osteocyte adhesion and dendrite formation.Deleting vinculin using the mouse 10-kb Dmp1-Cre transgenic mice causes dramatic bone loss in the weight-bearing long bones and spine,but not in the skull,in both young and aged mice by impairing osteoblast formation and function without markedly affecting bone resorption.Vinculin loss impairs the anabolic response of skeleton to mechanical loading in mice.Vinculin knockdown increases,while vinculin overexpression decreases,sclerostin expression in osteocytes without impacting expression of Mef2c,a major transcriptional regulator of the Sost gene,which encodes sclerostin.Vinculin interacts with Mef2c and retains the latter in the cytoplasm.Thus,vinculin loss enhances Mef2c nuclear translocation and binding to the Sost enhancer ECR5 to promote sclerostin expression in osteocytes and reduces bone formation.Consistent with this notion,deleting Sost expression in osteocytes reverses the osteopenic phenotypes caused by vinculin loss in mice.Finally,we find that estrogen is a novel regulator of vinculin expression in osteocytes and that vinculin-deficient mice are resistant to ovariectomy-induced bone loss.Thus,we demonstrate a novel mechanism through which vinculin inhibits the Mef2c-driven sclerostin expression in osteocytes to promote bone formation.展开更多
Grid-Forming(GFM)converters are prone to fault-induced overcurrent and power angle instability during grid fault-induced voltage sags.To address this,this paper develops a multi-loop coordinated fault ridethrough(FRT)...Grid-Forming(GFM)converters are prone to fault-induced overcurrent and power angle instability during grid fault-induced voltage sags.To address this,this paper develops a multi-loop coordinated fault ridethrough(FRT)control strategy based on a power outer loop and voltage-current inner loops,aiming to enhance the stability and current-limiting capability of GFM converters during grid fault conditions.During voltage sags,the GFM converter’s voltage source behavior is maintained by dynamically adjusting the reactive power reference to provide voltage support,thereby effectively suppressing the steady-state component of the fault current.To address the active power imbalance induced by voltage sags,a dynamic active power reference correction method based on apparent power is designed to mitigate power angle oscillations and limit transient current.Moreover,an adaptive virtual impedance loop is implemented to enhance dynamic transient current-limiting performance during the fault initiation phase.This approach improves the responsiveness of the inner loop and ensures safe system operation under various fault severities.Under asymmetric fault conditions,a negative-sequence reactive current compensation strategy is incorporated to further suppress negative-sequence voltage and improve voltage symmetry.The proposed control scheme enables coordinated operation of multiple control objectives,including voltage support,current suppression,and power angle stability,across different fault scenarios.Finally,MATLAB/Simulink simulation results validate the effectiveness of the proposed strategy,showcasing its superior performance in current limiting and power angle stability,thereby significantly enhancing the system’s fault ride-through capability.展开更多
Understanding water chemistry in karst regions is crucial for improving global water resource management and deepening our knowledge of the biogeochemical cycles shaping these sensitive environments.Despite advance-me...Understanding water chemistry in karst regions is crucial for improving global water resource management and deepening our knowledge of the biogeochemical cycles shaping these sensitive environments.Despite advance-ments in karst hydrology,significant gaps remain in long-term trends,underlying processes,and quantitative effects of environmental changes.This is especially true in areas like the Wujiang River(WJ)in China,where human activities such as reservoir construction and land use/cover changes have accelerated hydrochemical changes.We combined recent and historical monitoring data to provide a detailed analysis of the spatial and temporal characteristics,evolution,and controlling factors of major ions in WJ.These findings are important for local water management and contribute to global efforts to manage similar karst systems facing human-induced pressures.Our research shows clear seasonal differences in solute concentrations,with higher levels during the dry season.WJ’s water is rich in calcium,with Ca-HCO_(3) ion pairs being the most common.Reservoir monitor-ing stations show much higher levels of NO_(3)^(−)and SO_(4)^(2−)compared to river-type stations,likely due to longer hydraulic retention time and increased acid deposition.The study confirms the significant role of pH and water temperature in rock weathering processes.Land use/cover changes were identified as the primary drivers of solute variations(46.37%),followed by lithology(13.92%)and temperature(8.35%).Over the past two decades,in-tense carbonate weathering has been observed,especially during wet seasons.Among karstic provinces,Guizhou Province stands out with the highest ion concentrations,indicative of its extensive karst coverage and heightened weathering processes.展开更多
Energy-regenerative suspension combined with piezoelectric and electromagnetic transduction has evolved into a core technological pathway in advancing automotive design paradigms.With the aim of improving energy harve...Energy-regenerative suspension combined with piezoelectric and electromagnetic transduction has evolved into a core technological pathway in advancing automotive design paradigms.With the aim of improving energy harvesting performance,time-delayed feedback control is widely used in an energy-regenerative suspension system under different external disturbances in this paper.Meanwhile,limited research has addressed the stochastic dynamics of time-delayed nonlinear energy-regenerative suspension systems.Different from previous studies,this work studies the stochastic response and P-bifurcation of the nonlinear energy-regenerative suspension system with time-delayed feedback control.Firstly,an approximately equivalent dimension reduction system is established by the variable transformation method,and then the stationary probability density function of amplitude is obtained by the stochastic averaging method.Secondly,the precision of the method used in this work is verified by comparing the numerical solutions with the analytical results.Finally,based on the stationary probability density function,the influence of system parameters on stochastic P-bifurcation and the mean output power is discussed.展开更多
Although the effectiveness of a tuned viscous mass damper(TVMD)as an inerter-based device for vibration control in civil structures has been thoroughly investigated,there is a lack of systematic research regarding the...Although the effectiveness of a tuned viscous mass damper(TVMD)as an inerter-based device for vibration control in civil structures has been thoroughly investigated,there is a lack of systematic research regarding the application of TVMDs for seismic response control of industrial buildings coupled with mechanical equipment.Therefore,this study proposes ungrounded and grounded TVMDs to effectively utilize the mass of the mechanical equipment and fully exploit the capabilities of the inerter element.An optimal design methodology is developed by pursuing the maximum effective damping ratio and seeking the most rational TVMD control scheme.Validation of TVMD control performance is conducted through time-history analysis based on 20 real seismic ground motions recommended by ATC-40,and by providing a barrel mixer industrial building as a real-life numerical example.The results show that both an ungrounded and grounded TVMD can effectively mitigate the seismic response of the primary structure.Compared to the traditional tuned mass damper(TMD),TVMDs can obtain improved control performance for a given equipment mass ratio.Moreover,an ungrounded TVMD and a TMD show similar working mechanisms that tend to release the displacement of equipment to keep their optimal state,whereas equipment displacement for a grounded TVMD should be strictly limited to provide sufficient anti-force.展开更多
In wind power transmission via modular multilevel converter based high voltage direct current(MMCHVDC)systems,under traditional control strategies,MMC-HVDCcannot provide inertia support to the receiving-end grid(REG)d...In wind power transmission via modular multilevel converter based high voltage direct current(MMCHVDC)systems,under traditional control strategies,MMC-HVDCcannot provide inertia support to the receiving-end grid(REG)during disturbances.Moreover,due to the frequency decoupling between the two ends of the MMCHVDC,the sending-end wind farm(SEWF)cannot obtain the frequency variation information of the REG to provide inertia response.Therefore,this paper proposes a novel coordinated source-network-storage inertia control strategy based on wind power transmission via MMC-HVDC system.First,the grid-side MMC station(GS-MMC)maps the frequency variations of the REG to direct current(DC)voltage variations through the frequency mapping control,and uses submodule capacitor energy to provide inertial power.Then,the wind farm-side MMC station(WF-MMC)restores the DC voltage variations to frequency variations through the frequency restoration control and power loss compensation,providing real-time frequency information for the wind farm.Finally,based on real-time frequency information,thewind farmutilizes the rotor kinetic energy and energy storage to provide fast and lasting power support through the wind-storage coordinated inertia control strategy.Meanwhile,when the wind turbines withdraw from the inertia response phase,the energy storage can increase the power output to compensate for the power deficit,preventing secondary frequency drops.Furthermore,this paper uses small-signal analysis to determine the appropriate values for the key parameters of the proposed control strategy.A simulation model of the wind power transmission via MMCHVDC system is built in MATLAB/Simulink environment to validate and evaluate the proposed method.The results show that the proposed coordinated control strategy can effectively improve the system inertia level and avoid the secondary frequency drop under the load sudden increase condition.展开更多
Quantum control allows a wide range of quantum operations employed in molecular physics,nuclear magnetic resonance and quantum information processing.Thanks to the existing microelectronics industry,semiconducting qub...Quantum control allows a wide range of quantum operations employed in molecular physics,nuclear magnetic resonance and quantum information processing.Thanks to the existing microelectronics industry,semiconducting qubits,where quantum information is encoded in spin or charge degree freedom of electrons or nuclei in semiconductor quantum dots,constitute a highly competitive candidate for scalable solid-state quantum technologies.In quantum information processing,advanced control techniques are needed to realize quantum manipulations with both high precision and noise resilience.In this review,we first introduce the basics of various widely-used control methods,including resonant excitation,adabatic passage,shortcuts to adiabaticity,composite pulses,and quantum optimal control.Then we review the practical aspects in applying these methods to realize accurate and robust quantum gates for single semiconductor qubits,such as Loss–DiVincenzo spin qubit,spinglet-triplet qubit,exchange-only qubit and charge qubit.展开更多
Skeletal muscle health and function are essential determinants of metabolic health,physical performance,and overall quality of life.The quality of skeletal muscle is heavily dependent on the complex mitochondrial reti...Skeletal muscle health and function are essential determinants of metabolic health,physical performance,and overall quality of life.The quality of skeletal muscle is heavily dependent on the complex mitochondrial reticulum that contributes toward its unique adaptability.It is now recognized that mitochondrial perturbations can activate various innate immune pathways,such as the nucleotide-binding oligomerization domain(NOD)-like receptor protein 3(NLRP3)inflammasome complex by propagating inflammatory signaling in response to damage-associated molecular patterns(DAMPs).The NLRP3 inflammasome is a multimeric protein complex and is a prominent regulator of innate immunity and cell death by mediating the activation of caspase-1,pro-inflammatory cytokines interleukin-1βand interleukin-18 and pro-pyroptotic protein gasdermin-D.While several studies have begun to demonstrate the relationship between various mitochondrial DAMPs(mtDAMPs)and NLRP3 inflammasome activation,the influence of various metabolic states on the production of these DAMPs and subsequent inflammatory profile remains poorly understood.This narrative review aimed to address this by highlighting the effects of skeletal muscle use and disuse on mitochondrial quality mechanisms including mitochondrial biogenesis,fusion,fission and mitophagy.Secondly,this review summarized the impact of alterations in mitochondrial quality control mechanisms following muscle denervation,aging,and exercise training in relation to NLRP3 inflammasome activation.By consolidating the current body of literature,this work aimed to further the understanding of innate immune signaling within skeletal muscle,which can highlight areas for future research and therapeutic strategies to regulate NLRP3 inflammasome activation during divergent metabolic conditions.展开更多
文摘The Edikan Mine,which consists of Fobinso and Esuajah gold deposits,lies within the Asankrangwa Gold Belt of the Birimian Supergroup in the Kumasi Basin.The metasedimentary rocks in the Basins and the faulted metavolcanic rocks in the Belts that make up the Birimian Supergroup were intruded by granitoids during the Eburnean Orogeny.This research aims to classify granitoids in the Edikan Mine and ascertain the petrogenetic and geochemical characteristics of some auriferous granitoids in the wider Kumasi Basin,Ghana,to understand the implications for geodynamic settings.A multi-methods approach involving field studies,petrographic studies,and whole-rock geochemical analysis was used to achieve the goal of the study.Petrographic studies revealed a relatively high abundance of plagioclase and a low percentage of K-feldspars(anorthoclase and orthoclase)in the Fobinso samples,suggesting that the samples are granodioritic in nature,while the Esuajah samples showed relatively low plagioclase abundance and a high percentage in K-feldspars,indicating that they are granitic.The granitoids from the study areas are co-magmatic.The granitoids in Esuajah and Fobinso are generally enriched in large ion lithophile elements and light rare earth elements than high field strength elements,middle rare earth elements,and heavy rare earth elements,indicating mixing with crustal sources during the evolution of the granitoids.The granitoids were tectonically formed in a syn-collisional+VAG setting,which implies that they were formed in the subduction zone setting.Fobinso granodiorites showed S-type signatures with evidence of extensive crustal contamination,while the Esuajah granites showed I-type signatures with little or no crustal contamination and are peraluminous.Gold mineralization in the study area is structurally and lithologically controlled with shear zones,faulting,and veining as the principal structures controlling the mineralization.The late-stage vein,V3,in the Edikan Mine is characterized by a low vein angle and is mineralized.
基金supported by the Natural Science Foundation of Shandong Province,No.ZR2023MC168the National Natural Science Foundation of China,No.31670989the Key R&D Program of Shandong Province,No.2019GSF107037(all to CS).
文摘Vascular endothelial growth factor and its mimic peptide KLTWQELYQLKYKGI(QK)are widely used as the most potent angiogenic factors for the treatment of multiple ischemic diseases.However,conventional topical drug delivery often results in a burst release of the drug,leading to transient retention(inefficacy)and undesirable diffusion(toxicity)in vivo.Therefore,a drug delivery system that responds to changes in the microenvironment of tissue regeneration and controls vascular endothelial growth factor release is crucial to improve the treatment of ischemic stroke.Matrix metalloproteinase-2(MMP-2)is gradually upregulated after cerebral ischemia.Herein,vascular endothelial growth factor mimic peptide QK was self-assembled with MMP-2-cleaved peptide PLGLAG(TIMP)and customizable peptide amphiphilic(PA)molecules to construct nanofiber hydrogel PA-TIMP-QK.PA-TIMP-QK was found to control the delivery of QK by MMP-2 upregulation after cerebral ischemia/reperfusion and had a similar biological activity with vascular endothelial growth factor in vitro.The results indicated that PA-TIMP-QK promoted neuronal survival,restored local blood circulation,reduced blood-brain barrier permeability,and restored motor function.These findings suggest that the self-assembling nanofiber hydrogel PA-TIMP-QK may provide an intelligent drug delivery system that responds to the microenvironment and promotes regeneration and repair after cerebral ischemia/reperfusion injury.
文摘The application of generative artificial intelligence(GAI)in the judicial domain represents an innovative approach to achieving digital justice.GAI’s functionalities are primarily exhibited in the enhancement of judicial efficiency,improving the accuracy and fairness of adjudications,promoting the uniform application of the law,and enhancing transparency and engagement in judicial processes.However,these advancements are accompanied by potential risks and challenges in technology,adjudication,and ethics.It is thus essential to strengthen privacy protection during the processing and transmission of data,ensure data security and confidentiality,and establish and refine clear legal norms regarding the roles,responsibilities,and legal obligations of GAI in judicial settings.In addition,ethical guidelines that delineate the behavioral boundaries and value orientations of GAI need to be formulated.Collectively,these elements can form a trinary model of technical controls,legal norms,and ethical constraints,to facilitate the modernization and intelligent development of the judicial system.
文摘Identifying key acupuncture elements is essential for optimizing sham acupuncture controls.Based on the characteristics and current state of acupuncture therapy,this paper categorizes key acupuncture elements into types and contents.Taking the former as a clue,it examines the current understanding of key acupuncture elements and underscores the need for further refinement to ensure that sham acupuncture controls more closely approximate physiological inertness.Additionally,it explores strategies and methodologies for advancing the understanding of key acupuncture elements from both the type and content perspectives.Key acupuncture elements should expand the number of included element types.Elements such as acupuncture needles,point selection,point combination,needle insertion,needle manipulation,and needle withdrawal should all be included,and they should be reported in a standardized manner in the trials.Regarding element content,improvements should be made in three key areas to enhance selection accuracy:1.Strengthening the comprehensiveness of relevant theoretical frameworks.2.Emphasizing the role of Traditional Chinese Medicine(TCM)diagnosis and acupoint palpation methods in trial application and reporting.3.Continuously investigating the mechanisms underlying both the specific efficacy and the placebo efficacy of acupuncture.
文摘Aiming to solve the steering instability and hysteresis of agricultural robots in the process of movement,a fusion PID control method of particle swarm optimization(PSO)and genetic algorithm(GA)was proposed.The fusion algorithm took advantage of the fast optimization ability of PSO to optimize the population screening link of GA.The Simulink simulation results showed that the convergence of the fitness function of the fusion algorithm was accelerated,the system response adjustment time was reduced,and the overshoot was almost zero.Then the algorithm was applied to the steering test of agricultural robot in various scenes.After modeling the steering system of agricultural robot,the steering test results in the unloaded suspended state showed that the PID control based on fusion algorithm reduced the rise time,response adjustment time and overshoot of the system,and improved the response speed and stability of the system,compared with the artificial trial and error PID control and the PID control based on GA.The actual road steering test results showed that the PID control response rise time based on the fusion algorithm was the shortest,about 4.43 s.When the target pulse number was set to 100,the actual mean value in the steady-state regulation stage was about 102.9,which was the closest to the target value among the three control methods,and the overshoot was reduced at the same time.The steering test results under various scene states showed that the PID control based on the proposed fusion algorithm had good anti-interference ability,it can adapt to the changes of environment and load and improve the performance of the control system.It was effective in the steering control of agricultural robot.This method can provide a reference for the precise steering control of other robots.
基金Supported in part by Natural Science Foundation of Guangxi(2023GXNSFAA026246)in part by the Central Government's Guide to Local Science and Technology Development Fund(GuikeZY23055044)in part by the National Natural Science Foundation of China(62363003)。
文摘In this paper,we consider the maximal positive definite solution of the nonlinear matrix equation.By using the idea of Algorithm 2.1 in ZHANG(2013),a new inversion-free method with a stepsize parameter is proposed to obtain the maximal positive definite solution of nonlinear matrix equation X+A^(*)X|^(-α)A=Q with the case 0<α≤1.Based on this method,a new iterative algorithm is developed,and its convergence proof is given.Finally,two numerical examples are provided to show the effectiveness of the proposed method.
基金supported by the National Science Foundation of China(No.62171387)the Science and Technology Program of Sichuan Province(No.2024NSFSC0468)the China Postdoctoral Science Foundation(No.2019M663475).
文摘As an important resource in data link,time slots should be strategically allocated to enhance transmission efficiency and resist eavesdropping,especially considering the tremendous increase in the number of nodes and diverse communication needs.It is crucial to design control sequences with robust randomness and conflict-freeness to properly address differentiated access control in data link.In this paper,we propose a hierarchical access control scheme based on control sequences to achieve high utilization of time slots and differentiated access control.A theoretical bound of the hierarchical control sequence set is derived to characterize the constraints on the parameters of the sequence set.Moreover,two classes of optimal hierarchical control sequence sets satisfying the theoretical bound are constructed,both of which enable the scheme to achieve maximum utilization of time slots.Compared with the fixed time slot allocation scheme,our scheme reduces the symbol error rate by up to 9%,which indicates a significant improvement in anti-interference and eavesdropping capabilities.
文摘In this paper,we define for the trace operator,the solution of certain models of vibrating plates standards with initial data in a strategic region spaces of weak regularities.Indeed,we know that the notion of regional controllability is more adapted to systems described by dynamic systems.Regional controllability results in a strategic area were established for vibrating plates by the Hilbertian Uniqueness Method.
基金supported by Youth Innovation Promotion Association of Chinese Academy of Sciences(No.2020261)Strategic Priority Research Program of Chinese Academy of Sciences(No.XDA02010000)the Young Potential Program of Shanghai Institute of Applied Physics,Chinese Academy of Sciences(No.SINAP-YXJH-202412).
文摘Molten salt reactors,being the only reactor type among Generation Ⅳ advanced nuclear reactors that utilize liquid fuels,offer inherent safety,high-temperature,and low-pressure operation,as well as the capability for online fuel reprocessing.However,the fuel-salt flow results in the decay of delayed neutron precursors(DNPs)outside the core,causing fluctuations in the effective delayed neutron fraction and consequently impacting the reactor reactivity.Particularly in accident scenarios—such as a combined pump shutdown and the inability to rapidly scram the reactor—the sole reliance on negative temperature feedback may cause a significant increase in core temperature,posing a threat to reactor safety.To address these problems,this paper introduces an innovative design for a passive fluid-driven suspended control rod(SCR)to dynamically compensate for reactivity fluctuations caused by DNPs flowing with the fuel.The control rod operates passively by leveraging the combined effects of gravity,buoyancy,and fluid dynamic forces,thereby eliminating the need for an external drive mechanism and enabling direct integration within the active region of the core.Using a 150 MWt thorium-based molten salt reactor as the reference design,we develop a mathematical model to systematically analyze the effects of key parameters—including the geometric dimensions and density of the SCR—on its performance.We examine its motion characteristics under different core flow conditions and assess its feasibility for the dynamic compensation of reactivity changes caused by fuel flow.The results of this study demonstrate that the SCR can effectively counteract reactivity fluctuations induced by fuel flow within molten salt reactors.A sensitivity analysis reveals that the SCR’s average density exerts a profound impact on its start-up flow threshold,channel flow rate,resistance to fuel density fluctuations,and response characteristics.This underscores the critical need to optimize this parameter.Moreover,by judiciously selecting the SCR’s length,number of deployed units,and the placement we can achieve the necessary reactivity control while maintaining a favorable balance between neutron economy and heat transfer performance.Ultimately,this paper provides an innovative solution for the passive reactivity control in molten salt reactors,offering significant potential for practical engineering applications.
基金the Deanship of Scientific Research at Northern Border University,Arar,Saudi Arabia,for funding this research work through the project number“NBU-FFR-2025-3623-11”.
文摘Modern power systems increasingly depend on interconnected microgrids to enhance reliability and renewable energy utilization.However,the high penetration of intermittent renewable sources often causes frequency deviations,voltage fluctuations,and poor reactive power coordination,posing serious challenges to grid stability.Conventional Interconnection FlowControllers(IFCs)primarily regulate active power flowand fail to effectively handle dynamic frequency variations or reactive power sharing in multi-microgrid networks.To overcome these limitations,this study proposes an enhanced Interconnection Flow Controller(e-IFC)that integrates frequency response balancing and an Interconnection Reactive Power Flow Controller(IRFC)within a unified adaptive control structure.The proposed e-IFC is implemented and analyzed in DIgSILENT PowerFactory to evaluate its performance under various grid disturbances,including frequency drops,load changes,and reactive power fluctuations.Simulation results reveal that the e-IFC achieves 27.4% higher active power sharing accuracy,19.6% lower reactive power deviation,and 18.2% improved frequency stability compared to the conventional IFC.The adaptive controller ensures seamless transitions between grid-connected and islanded modes and maintains stable operation even under communication delays and data noise.Overall,the proposed e-IFCsignificantly enhances active-reactive power coordination and dynamic stability in renewable-integrated multi-microgrid systems.Future research will focus on coupling the e-IFC with tertiary-level optimization frameworks and conducting hardware-in-the-loop validation to enable its application in large-scale smart microgrid environments.
文摘Conventional multilevel inverters often suffer from high harmonic distortion and increased design complexity due to the need for numerous power semiconductor components,particularly at elevated voltage levels.Addressing these shortcomings,thiswork presents a robust 15-level PackedUCell(PUC)inverter topology designed for renewable energy and grid-connected applications.The proposed systemintegrates a sensor less proportional-resonant(PR)controller with an advanced carrier-based pulse width modulation scheme.This approach efficiently balances capacitor voltage,minimizes steady-state error,and strongly suppresses both zero and third-order harmonics resulting in reduced total harmonic distortion and enhanced voltage regulation.Additionally,a novel switching algorithm simplifies the design and implementation,further lowering voltage stress across switches.Extensive simulation results validate the performance under various resistive and resistive-inductive load conditions,demonstrating compliance with IEEE-519 THD standards and robust operation under dynamic changes.The proposed sensorless PR-controlled 15-PUC inverter thus offers a compelling,cost-effective solution for efficient power conversion in next-generation renewable energy systems.
基金supported in part by the National Natural Science Foundation of China,Grant/Award Number:62003267the Key Research and Development Program of Shaanxi Province,Grant/Award Number:2023-GHZD-33Open Project of the State Key Laboratory of Intelligent Game,Grant/Award Number:ZBKF-23-05。
文摘To address the issue of instability or even imbalance in the orientation and attitude control of quadrotor unmanned aerial vehicles(QUAVs)under random disturbances,this paper proposes a distributed antidisturbance data-driven event-triggered fusion control method,which achieves efficient fault diagnosis while suppressing random disturbances and mitigating communication conflicts within the QUAV swarm.First,the impact of random disturbances on the UAV swarm is analyzed,and a model for orientation and attitude control of QUAVs under stochastic perturbations is established,with the disturbance gain threshold determined.Second,a fault diagnosis system based on a high-gain observer is designed,constructing a fault gain criterion by integrating orientation and attitude information from QUAVs.Subsequently,a model-free dynamic linearization-based data modeling(MFDLDM)framework is developed using model-free adaptive control,which efficiently fits the nonlinear control model of the QUAV swarm while reducing temporal constraints on control data.On this basis,this paper constructs a distributed data-driven event-triggered controller based on the staggered communication mechanism,which consists of an equivalent QUAV controller and an event-triggered controller,and is able to reduce the communication conflicts while suppressing the influence of random interference.Finally,by incorporating random disturbances into the controller,comparative experiments and physical validations are conducted on the QUAV platforms,fully demonstrating the strong adaptability and robustness of the proposed distributed event-triggered fault-tolerant control system.
基金supported,in part,the Shenzhen Medical Research Funds(B2402033)the Shenzhen Fundamental Research Program(JCYJ20220818100617036)+3 种基金the National Natural Science Foundation of China Grants(82250710175,82261160395,82430078,82230081)the Guangdong Provincial Science and Technology Innovation Council Grant(2017B030301018)the National Key Research and Development Program of China Grant(2019YFA0906004)the China Postdoctoral Science Foundation(2021M691435).
文摘The focal adhesion(FA)is the structural basis of the cell-extracellular matrix crosstalk and plays important roles in control of organ formation and function.Here we show that expression of FA protein vinculin is dramatically reduced in osteocytes in patients with aging-related osteoporosis.Vinculin loss severely impaired osteocyte adhesion and dendrite formation.Deleting vinculin using the mouse 10-kb Dmp1-Cre transgenic mice causes dramatic bone loss in the weight-bearing long bones and spine,but not in the skull,in both young and aged mice by impairing osteoblast formation and function without markedly affecting bone resorption.Vinculin loss impairs the anabolic response of skeleton to mechanical loading in mice.Vinculin knockdown increases,while vinculin overexpression decreases,sclerostin expression in osteocytes without impacting expression of Mef2c,a major transcriptional regulator of the Sost gene,which encodes sclerostin.Vinculin interacts with Mef2c and retains the latter in the cytoplasm.Thus,vinculin loss enhances Mef2c nuclear translocation and binding to the Sost enhancer ECR5 to promote sclerostin expression in osteocytes and reduces bone formation.Consistent with this notion,deleting Sost expression in osteocytes reverses the osteopenic phenotypes caused by vinculin loss in mice.Finally,we find that estrogen is a novel regulator of vinculin expression in osteocytes and that vinculin-deficient mice are resistant to ovariectomy-induced bone loss.Thus,we demonstrate a novel mechanism through which vinculin inhibits the Mef2c-driven sclerostin expression in osteocytes to promote bone formation.
文摘Grid-Forming(GFM)converters are prone to fault-induced overcurrent and power angle instability during grid fault-induced voltage sags.To address this,this paper develops a multi-loop coordinated fault ridethrough(FRT)control strategy based on a power outer loop and voltage-current inner loops,aiming to enhance the stability and current-limiting capability of GFM converters during grid fault conditions.During voltage sags,the GFM converter’s voltage source behavior is maintained by dynamically adjusting the reactive power reference to provide voltage support,thereby effectively suppressing the steady-state component of the fault current.To address the active power imbalance induced by voltage sags,a dynamic active power reference correction method based on apparent power is designed to mitigate power angle oscillations and limit transient current.Moreover,an adaptive virtual impedance loop is implemented to enhance dynamic transient current-limiting performance during the fault initiation phase.This approach improves the responsiveness of the inner loop and ensures safe system operation under various fault severities.Under asymmetric fault conditions,a negative-sequence reactive current compensation strategy is incorporated to further suppress negative-sequence voltage and improve voltage symmetry.The proposed control scheme enables coordinated operation of multiple control objectives,including voltage support,current suppression,and power angle stability,across different fault scenarios.Finally,MATLAB/Simulink simulation results validate the effectiveness of the proposed strategy,showcasing its superior performance in current limiting and power angle stability,thereby significantly enhancing the system’s fault ride-through capability.
基金supported by Guangdong Basic and Applied Basic Research Foundation(Nos.2023A1515110824 and 2025A1515011839)Shenzhen Science and Technology Program(No.RCBS20231211090638066).
文摘Understanding water chemistry in karst regions is crucial for improving global water resource management and deepening our knowledge of the biogeochemical cycles shaping these sensitive environments.Despite advance-ments in karst hydrology,significant gaps remain in long-term trends,underlying processes,and quantitative effects of environmental changes.This is especially true in areas like the Wujiang River(WJ)in China,where human activities such as reservoir construction and land use/cover changes have accelerated hydrochemical changes.We combined recent and historical monitoring data to provide a detailed analysis of the spatial and temporal characteristics,evolution,and controlling factors of major ions in WJ.These findings are important for local water management and contribute to global efforts to manage similar karst systems facing human-induced pressures.Our research shows clear seasonal differences in solute concentrations,with higher levels during the dry season.WJ’s water is rich in calcium,with Ca-HCO_(3) ion pairs being the most common.Reservoir monitor-ing stations show much higher levels of NO_(3)^(−)and SO_(4)^(2−)compared to river-type stations,likely due to longer hydraulic retention time and increased acid deposition.The study confirms the significant role of pH and water temperature in rock weathering processes.Land use/cover changes were identified as the primary drivers of solute variations(46.37%),followed by lithology(13.92%)and temperature(8.35%).Over the past two decades,in-tense carbonate weathering has been observed,especially during wet seasons.Among karstic provinces,Guizhou Province stands out with the highest ion concentrations,indicative of its extensive karst coverage and heightened weathering processes.
基金Project supported by the National Natural Science Foundation of China(Grant No.12002089)the Science and Technology Projects in Guangzhou(Grant No.2023A04J1323)UKRI Horizon Europe Guarantee(Marie SklodowskaCurie Fellowship)(Grant No.EP/Y016130/1)。
文摘Energy-regenerative suspension combined with piezoelectric and electromagnetic transduction has evolved into a core technological pathway in advancing automotive design paradigms.With the aim of improving energy harvesting performance,time-delayed feedback control is widely used in an energy-regenerative suspension system under different external disturbances in this paper.Meanwhile,limited research has addressed the stochastic dynamics of time-delayed nonlinear energy-regenerative suspension systems.Different from previous studies,this work studies the stochastic response and P-bifurcation of the nonlinear energy-regenerative suspension system with time-delayed feedback control.Firstly,an approximately equivalent dimension reduction system is established by the variable transformation method,and then the stationary probability density function of amplitude is obtained by the stochastic averaging method.Secondly,the precision of the method used in this work is verified by comparing the numerical solutions with the analytical results.Finally,based on the stationary probability density function,the influence of system parameters on stochastic P-bifurcation and the mean output power is discussed.
基金National Natural Science Foundation of China under Grant Nos.52408327 and 52278306Key Research and Development Program of Hunan Province,China under Grant No.2022SK2096+3 种基金Science and Technology Progress and Innovation Project of the Department of Transportation of Hunan Province,China under Grant No.201912Natural Science Foundation of Hunan Province,China under Grant No.2024JJ6198Scientific Research Project of the Education Department of Hunan Province,China under Grant No.25A0645Emergency Management Science and Technology Project of the Emergency Management Department of Hunan Province,China under Grant No.yjtkjxm_202406。
文摘Although the effectiveness of a tuned viscous mass damper(TVMD)as an inerter-based device for vibration control in civil structures has been thoroughly investigated,there is a lack of systematic research regarding the application of TVMDs for seismic response control of industrial buildings coupled with mechanical equipment.Therefore,this study proposes ungrounded and grounded TVMDs to effectively utilize the mass of the mechanical equipment and fully exploit the capabilities of the inerter element.An optimal design methodology is developed by pursuing the maximum effective damping ratio and seeking the most rational TVMD control scheme.Validation of TVMD control performance is conducted through time-history analysis based on 20 real seismic ground motions recommended by ATC-40,and by providing a barrel mixer industrial building as a real-life numerical example.The results show that both an ungrounded and grounded TVMD can effectively mitigate the seismic response of the primary structure.Compared to the traditional tuned mass damper(TMD),TVMDs can obtain improved control performance for a given equipment mass ratio.Moreover,an ungrounded TVMD and a TMD show similar working mechanisms that tend to release the displacement of equipment to keep their optimal state,whereas equipment displacement for a grounded TVMD should be strictly limited to provide sufficient anti-force.
基金funded by State Grid Corporation of China Central Branch Technology Project(52140024000C).
文摘In wind power transmission via modular multilevel converter based high voltage direct current(MMCHVDC)systems,under traditional control strategies,MMC-HVDCcannot provide inertia support to the receiving-end grid(REG)during disturbances.Moreover,due to the frequency decoupling between the two ends of the MMCHVDC,the sending-end wind farm(SEWF)cannot obtain the frequency variation information of the REG to provide inertia response.Therefore,this paper proposes a novel coordinated source-network-storage inertia control strategy based on wind power transmission via MMC-HVDC system.First,the grid-side MMC station(GS-MMC)maps the frequency variations of the REG to direct current(DC)voltage variations through the frequency mapping control,and uses submodule capacitor energy to provide inertial power.Then,the wind farm-side MMC station(WF-MMC)restores the DC voltage variations to frequency variations through the frequency restoration control and power loss compensation,providing real-time frequency information for the wind farm.Finally,based on real-time frequency information,thewind farmutilizes the rotor kinetic energy and energy storage to provide fast and lasting power support through the wind-storage coordinated inertia control strategy.Meanwhile,when the wind turbines withdraw from the inertia response phase,the energy storage can increase the power output to compensate for the power deficit,preventing secondary frequency drops.Furthermore,this paper uses small-signal analysis to determine the appropriate values for the key parameters of the proposed control strategy.A simulation model of the wind power transmission via MMCHVDC system is built in MATLAB/Simulink environment to validate and evaluate the proposed method.The results show that the proposed coordinated control strategy can effectively improve the system inertia level and avoid the secondary frequency drop under the load sudden increase condition.
基金support by the National Natural Science Foundation of China(Nos.12174379,E31Q02BG)the Chinese Academy of Sciences(Nos.E0SEBB11,E27RBB11)+1 种基金the Innovation Program for Quantum Science and Technology(No.2021ZD0302300)Chinese Academy of Sciences Project for Young Scientists in Basic Research(No.YSBR-090)。
文摘Quantum control allows a wide range of quantum operations employed in molecular physics,nuclear magnetic resonance and quantum information processing.Thanks to the existing microelectronics industry,semiconducting qubits,where quantum information is encoded in spin or charge degree freedom of electrons or nuclei in semiconductor quantum dots,constitute a highly competitive candidate for scalable solid-state quantum technologies.In quantum information processing,advanced control techniques are needed to realize quantum manipulations with both high precision and noise resilience.In this review,we first introduce the basics of various widely-used control methods,including resonant excitation,adabatic passage,shortcuts to adiabaticity,composite pulses,and quantum optimal control.Then we review the practical aspects in applying these methods to realize accurate and robust quantum gates for single semiconductor qubits,such as Loss–DiVincenzo spin qubit,spinglet-triplet qubit,exchange-only qubit and charge qubit.
文摘Skeletal muscle health and function are essential determinants of metabolic health,physical performance,and overall quality of life.The quality of skeletal muscle is heavily dependent on the complex mitochondrial reticulum that contributes toward its unique adaptability.It is now recognized that mitochondrial perturbations can activate various innate immune pathways,such as the nucleotide-binding oligomerization domain(NOD)-like receptor protein 3(NLRP3)inflammasome complex by propagating inflammatory signaling in response to damage-associated molecular patterns(DAMPs).The NLRP3 inflammasome is a multimeric protein complex and is a prominent regulator of innate immunity and cell death by mediating the activation of caspase-1,pro-inflammatory cytokines interleukin-1βand interleukin-18 and pro-pyroptotic protein gasdermin-D.While several studies have begun to demonstrate the relationship between various mitochondrial DAMPs(mtDAMPs)and NLRP3 inflammasome activation,the influence of various metabolic states on the production of these DAMPs and subsequent inflammatory profile remains poorly understood.This narrative review aimed to address this by highlighting the effects of skeletal muscle use and disuse on mitochondrial quality mechanisms including mitochondrial biogenesis,fusion,fission and mitophagy.Secondly,this review summarized the impact of alterations in mitochondrial quality control mechanisms following muscle denervation,aging,and exercise training in relation to NLRP3 inflammasome activation.By consolidating the current body of literature,this work aimed to further the understanding of innate immune signaling within skeletal muscle,which can highlight areas for future research and therapeutic strategies to regulate NLRP3 inflammasome activation during divergent metabolic conditions.
