[Objectives] The research aimed to optimize extraction process of Clerodendrum philippinum Schauer var. simplex Mlodenke total flavonoids( CPTF),and provide reference for its development and utilization. [Methods] Bas...[Objectives] The research aimed to optimize extraction process of Clerodendrum philippinum Schauer var. simplex Mlodenke total flavonoids( CPTF),and provide reference for its development and utilization. [Methods] Based on single-factor test,ethanol concentration,extraction temperature and extraction time were taken as independent variables,and total flavonoids yield was taken as dependent variable. The test was conducted according to central composite design principle. Multivariate linear regression and binomial equation fitting of the result were conducted,and extraction process of CPTF was optimized by using response surface methodology. [Results]The optimal extraction process of CPTF was as below: ethanol concentration 54. 76%,extraction temperature 83. 92℃,extraction time 102. 64 min,solid-liquid ratio 1:20,extraction for twice. [Conclusions] The extraction process of CPTF by central composite design-response surface methodology was simple and feasible,with reliable prediction result,which was suitable for industrial production.展开更多
[Objectives]To optimize extraction process of total flavonoids from Akebia trifoliata( Thunb.) Koidz.,so as to provide references for development and use of Akebia trifoliata( Thunb.) Koidz. [Methods]The extraction ra...[Objectives]To optimize extraction process of total flavonoids from Akebia trifoliata( Thunb.) Koidz.,so as to provide references for development and use of Akebia trifoliata( Thunb.) Koidz. [Methods]The extraction rate of total flavonoids of Akebia trifoliata( Thunb.)Koidz. was taken as observation indicator. On the basis of single factor experiment,central composite design( CCD) was used to evaluate the effects of the extraction temperature,extraction time,and ethanol concentration on the extraction process. Multiple linear regression and binomial fitting were used,and response surface methodology( RSM) was used to select the optimum extraction process. [Results] The optimum extraction process conditions for total flavonoids of Akebia trifoliata( Thunb.) Koidz. was extraction temperature: 83. 92 ℃; extraction time:96. 47 min; ethanol concentration: 63. 92%; extraction times: two times; solid to liquid ratio: 1 ∶ 20; extraction rate of total flavonoids:4. 55%. [Conclusions] The central composite design-response surface methodology( CCD-RSM) is simple,convenient,and feasible for extraction of total flavonoids from Akebia trifoliata( Thunb.) Koidz.,and the prediction results are reliable.展开更多
This paper examined how microstructure influences the homogenized thermal conductivity of cellular structures and revealed a surface-induced size-dependent effect.This effect is linked to the porous microstructural fe...This paper examined how microstructure influences the homogenized thermal conductivity of cellular structures and revealed a surface-induced size-dependent effect.This effect is linked to the porous microstructural features of cellular structures,which stems from the degree of porosity and the distri-bution of the pores.Unlike the phonon-driven surface effect at the nanoscale,the macro-scale surface mechanism in thermal cellular structures is found to be the microstructure-induced changes in the heat conduction path based on fully resolved 3D numerical simulations.The surface region is determined by the microstructure,characterized by the intrinsic length.With the coupling between extrinsic and intrinsic length scales under the surface mechanism,a surface-enriched multiscale method was devel-oped to accurately capture the complex size-dependent thermal conductivity.The principle of scale separation required by classical multiscale methods is not necessary to be satisfied by the proposed multiscale method.The significant potential of the surface-enriched multiscale method was demon-strated through simulations of the effective thermal conductivity of a thin-walled metamaterial struc-ture.The surface-enriched multiscale method offers higher accuracy compared with the classical multiscale method and superior efficiency over high-fidelity finite element methods.展开更多
In order to improve the quality of 3D printed raspberry preserves after post-processing,microwave ovens combining infrared and microwave methods were utilized.The effects of infrared heating temperature,infrared heati...In order to improve the quality of 3D printed raspberry preserves after post-processing,microwave ovens combining infrared and microwave methods were utilized.The effects of infrared heating temperature,infrared heating time,microwave power,microwave heating time on the center temperature,moisture content,the chroma(C*),the total color difference(ΔE*),shape fidelity,hardness,and the total anthocyanin content of 3D printed raspberry preserves were analyzed by response surface method(RSM).The results showed that under combining with the two methods,infrared heating improved the fidelity and quality degradation of printed products,while microwave heating enhanced the efficiency of infrared heating.Infrared-microwave combination cooking could maintain relatively stable color appearance and shape of 3D printed raspberry preserves.The AHP–CRITIC hybrid weighting method combined with the response surface test to determine the comprehensive weights of the evaluation indicators optimized the process parameters,and the optimal process parameters were obtained:infrared heating temperature of 190℃,infrared heating time of 10 min and 30 s,microwave power of 300 W,and microwave heating time of 2 min and 6 s.The 3D printed raspberry cooking methods obtained under the optimal conditions seldom had color variation,porous structure,uniform texture,and high shape fidelity,which retained the characteristics of personalized manufacturing by 3D printing.This study could provide a reference for the postprocessing and quality control of 3D cooking methods.展开更多
Anode-free lithium metal batteries are prone to capacity degradation and safety hazards due to the formation and growth of lithium dendrites.The interface between the current collector and deposited lithium plays a cr...Anode-free lithium metal batteries are prone to capacity degradation and safety hazards due to the formation and growth of lithium dendrites.The interface between the current collector and deposited lithium plays a critical role in preventing dendrite formation by regulating the thermodynamics and kinetics of lithium deposition.In this study,we develop a phase field model to investigate the influence of the current collector’s surface energy on lithium deposition morphology and its effect on the quality of the lithium metal film.It is demonstrated that a higher surface energy of the current collector promotes the growth of lithium metal along the surface of the current collector.Further,our simulation results show that a higher surface energy accelerates the formation of the lithium metal film while simultaneously reducing its surface roughness.By examining different contact angles and applied potentials,we construct a phase diagram of deposition morphology,illustrating that increased surface energy facilitates the dense and uniform deposition of lithium metal by preventing the formation of lithium filaments and voids.These findings provide new insights into the development and application of anode-free lithium metal batteries.展开更多
This study proposes an alternative calculation mode for stresses on the slip surface(SS).The calculation of the normal stress(NS)on the SS involves examining its composition and expanding its unknown using the Taylor ...This study proposes an alternative calculation mode for stresses on the slip surface(SS).The calculation of the normal stress(NS)on the SS involves examining its composition and expanding its unknown using the Taylor series.This expansion enables the reasonable construction of a function describing the NS on the SS.Additionally,by directly incorporating the nonlinear Generalized Hoke-Brown(GHB)strength criterion and utilizing the slope factor of safety(FOS)definition,a function of the shear stress on the SS is derived.This function considers the mutual feedback mechanism between the NS and strength parameters of the SS.The stress constraints conditions are then introduced at both ends of the SS based on the spatial stress relation of one point.Determining the slope FOS and stress solution for the SS involves considering the mechanical equilibrium conditions and the stress constraint conditions satisfied by the sliding body.The proposed approach successfully simulates the tension-shear stress zone near the slope top and provides an intuitive description of the concentration effect of compression-shear stress of the SS near the slope toe.Furthermore,compared to other methods,the present method demonstrates superior processing capabilities for the embedded nonlinear GHB strength criterion.展开更多
The aim of this study is to evaluate the uncertainty of 2πα and 2πβ surface emission rates using the windowless multiwire proportional counter method.This study used the Monte Carlo method (MCM) to validate the co...The aim of this study is to evaluate the uncertainty of 2πα and 2πβ surface emission rates using the windowless multiwire proportional counter method.This study used the Monte Carlo method (MCM) to validate the conventional Guide to the Expression of Uncertainty in Measurement (GUM) method.A dead time measurement model for the two-source method was established based on the characteristics of a single-channel measurement system,and the voltage threshold correction factor measurement function was indirectly obtained by fitting the threshold correction curve.The uncertainty in the surface emission rate was calculated using the GUM method and the law of propagation of uncertainty.The MCM provided clear definitions for each input quantity and its uncertainty distribution,and the simulation training was realized with a complete and complex mathematical model.The results of the surface emission rate uncertainty evaluation for four radioactive plane sources using both methods showed the uncertainty’s consistency E_(n)<0.070 for the comparison of each source,and the uncertainty results of the GUM were all lower than those of the MCM.However,the MCM has a more objective evaluation process and can serve as a validation tool for GUM results.展开更多
Nanomaterials have garnered recognition for their notable surface effects and demonstration of superior mechanical properties.Previous studies on the surface effects of nanomaterials,employing the finite element metho...Nanomaterials have garnered recognition for their notable surface effects and demonstration of superior mechanical properties.Previous studies on the surface effects of nanomaterials,employing the finite element method,often relied on simplified twodimensional models due to theoretical complexities.Consequently,these simplified models inadequately represent the mechanical properties of nanomaterials and fail to capture the substantial impact of surface effects,particularly the curvature dependence of nanosurfaces.This study applies the principle of minimum energy and leverages the Steigmann-Ogden surface theory of nanomaterials to formulate a novel finite element surface element that comprehensively accounts for surface effects.We conducted an analysis of the stress distribution and deformation characteristics of four typical 2D and 3D nanomaterial models.The accuracy of the developed surface element and finite element calculation method was verified through comparison with established references.The resulting finite element model provides a robust and compelling scientific approach for accurately predicting the mechanical performance of nanomaterials.展开更多
At present,noise reduction has become an urgent challenge across various fields.Whether in the context of household appliances in daily life or in the enhancement of stealth performance in military equipment,noise con...At present,noise reduction has become an urgent challenge across various fields.Whether in the context of household appliances in daily life or in the enhancement of stealth performance in military equipment,noise control technologies play a critical role.This study introduces a computational framework for simulating Helmholtz equationgoverned acoustic scattering using a boundary element method(BEM)integrated with Loop subdivision surfaces.By adopting the Loop subdivision scheme—a widely used computer-aided design(CAD)technique-the framework unifies geometric representation and physical field discretization,ensuring seamless compatibility with industrial CAD workflows.The core innovation lies in the novel integration of conditional generative adversarial networks(CGANs)into the subdivision surface BEM to assist and accelerate the numerical computation process.In this study,for the two cases examined,the results show that the CGAN-enhanced approach achieves substantial gains in computational efficiency without compromising accuracy.A hierarchical acceleration strategy is further proposed:the fast multipole method(FMM)first reduces baseline computational complexity,while CGAN-driven secondary acceleration and data augmentation enable real-time parameter exploration.Benchmark validations and practical engineering applications demonstrate the method’s robustness and scalability for large-scale structural-acoustic analysis.展开更多
The precise computation of nanoelectromechanical switches’(NEMS)multi-physical interactions requires advanced numerical models and is a crucial part of the development of micro-and nano-systems.This paper presents a ...The precise computation of nanoelectromechanical switches’(NEMS)multi-physical interactions requires advanced numerical models and is a crucial part of the development of micro-and nano-systems.This paper presents a novel compound numerical method to study the instability of a functionally graded(FG)beam-type NEMS,considering surface elasticity effects as stated by Gurtin-Murdoch theory in an Euler-Bernoulli beam.The presented method is based on a combination of the Method of Adjoints(MoA)together with the Bézier-based multistep technique.By utilizing the MoA,a boundary value problem(BVP)is turned into an initial value problem(IVP).The resulting IVP is then solved by employing a cost-efficient multi-step process.It is demonstrated that the mentioned method can arrive at a high level of accuracy.Furthermore,it is revealed that the stability of the presented methodology is far better than that of other common multi-step methods,such as Adams-Bashforth,particularly at higher step sizes.Finally,the effects of axially functionally graded(FG)properties on the pull-in phenomenon and the main design parameters of NEMS,including the detachment length,are inspected.It was shown that the main parameter of design is the modulus of elasticity of the material,as Silver(Ag),which had better mechanical properties,showed almost a 6%improvement compared to aluminum(Al).However,by applying the correct amount of material with sturdier surface parameters,such as Aluminum(Al),at certain points,the nanobeams’functionality can be improved even further by around 1.5%.展开更多
To address the challenges of poor surface quality and high energy consumption in marble cutting,this study introduces an auxiliary abrasive jet cutting technology enhanced by the use of polyacrylamide(PAM)as a dragred...To address the challenges of poor surface quality and high energy consumption in marble cutting,this study introduces an auxiliary abrasive jet cutting technology enhanced by the use of polyacrylamide(PAM)as a dragreducing additive.The effects of feed rate(50-300 mm/min),polymer concentration(0-0.5 g/L),and nozzle spacing(4-12 mm)on kerf width and surface roughness are systematically investigated through an orthogonal experimental design.Results reveal that feed rate emerges as themost significant factor(p<0.01),followed by PAM concentration and nozzle spacing.The optimal set of parameters,comprising a 200 mm/min feed rate,0.3 g/L PAM concentration,and 6mmnozzle spacing,achieves the narrowest kerf width(0.867 mm)and the lowest surface roughness(10.220μm).Analysis of the underlying mechanisms demonstrates that PAMenhances the energy efficiency of the jet by suppressing turbulent pulsations and increasing fluid viscoelasticity,thereby minimizing energy loss during the cutting process.展开更多
Triply periodic minimal surface(TPMS)-based bone implants are an innovative approach in orthopedic implantology,offering customized solutions for bone defect repair and regeneration.This review comprehensively examine...Triply periodic minimal surface(TPMS)-based bone implants are an innovative approach in orthopedic implantology,offering customized solutions for bone defect repair and regeneration.This review comprehensively examines the current research landscape of TPMS-based bone implants,addressing key challenges and proposing future directions.It explores design strategies aimed at optimizing mechanical strength and enhancing biological integration,with a particular emphasis on TPMS structures.These design strategies include graded,hierarchical,and hybrid designs,each contributing to the overall functionality and performance of the implants.This review also highlights state-of-the-art fabrication technologies,particularly advancements in additive manufacturing(AM)techniques for creating metal-based,polymer-based,and ceramic-based bone implants.The ability to precisely control the architecture of TPMS structures using AM techniques is crucial for tailoring the mechanical and biological properties of such implants.Furthermore,this review critically evaluates the biological performance of TPMS implants,focusing on their potential to promote bone ingrowth and regeneration.Key factors,such as mechanical properties,permeability,and biocompatibility,are examined to determine the effectiveness of these implants in clinical applications.By synthesizing existing knowledge and proposing innovative research directions,this review underscores the transformative potential of TPMS-based bone implants in orthopedic surgery.The objective is to improve clinical outcomes and enhance patient care through advanced implant designs and manufacturing techniques.展开更多
This paper addresses the Singular Optimal Control Problem(SOCP)for a surface-to-air missile with limited control,fully considering aerodynamic effects with a parabolic drag polar.This problem is an extension of the ty...This paper addresses the Singular Optimal Control Problem(SOCP)for a surface-to-air missile with limited control,fully considering aerodynamic effects with a parabolic drag polar.This problem is an extension of the typical Goddard problem.First,the classical Legendre-Clebsch condition is applied to derive optimal conditions for the singular angle of attack,revealing that the missile turns by gravity along the singular arc.Second,the higher-order differentiation of the switching function provides the necessary conditions to determine the optimal thrust,expressed as linear functions of the costate variables.The vanishing coefficient determinant is then employed to decouple the control and costate variables,yielding the singular thrust solely dependent on state variables and identifying the singular surface.Moreover,the analytical singular control can be regarded as path constraints subject to the typical Optimal Control Problem(OCP),enabling the GPOPS-Ⅱ,a direct method framework that does not involve the singular condition,to solve the SOCP.Finally,three cases with different structures are presented to evaluate the performance of the proposed method.The results show that it takes a few steps to obtain the numerical optimal solution,which is consistent with the analytical solution derived from the calculus of variations,highlighting its great computational accuracy and effectiveness.展开更多
This study presents a numerical investigation of shallow water wave dynamics with particular emphasis on the role of surface tension.In the absence of surface tension,shallow water waves are primarily driven by gravit...This study presents a numerical investigation of shallow water wave dynamics with particular emphasis on the role of surface tension.In the absence of surface tension,shallow water waves are primarily driven by gravity and are well described by the classical Boussinesq equation,which incorporates fourth-order dispersion.Under this framework,solitary and shock waves arise through the balance of nonlinearity and gravity-induced dispersion,producing waveforms whose propagation speed,amplitude,and width depend largely on depth and initial disturbance.The resulting dynamics are comparatively smoother,with solitary waves maintaining coherent structures and shock waves displaying gradual transitions.When surface tension is incorporated,however,the dynamics become significantly richer.Surface tension introduces additional sixth-order dispersive terms into the governing equation,extending the classical model to the sixth-order Boussinesq equation.This higher-order dispersion modifies the balance between nonlinearity and dispersion,leading to sharper solitary wave profiles,altered shock structures,and a stronger sensitivity of wave stability to parametric variations.Surface tension effects also change the scaling laws for wave amplitude and velocity,producing conditions where solitary waves can narrow while maintaining large amplitudes,or where shock fronts steepen more rapidly compared to the tension-free case.These differences highlight how capillary forces,though often neglected in macroscopic wave studies,play a fundamental role in shaping dynamics at smaller scales or in systems with strong fluid–interface interactions.The analysis in this work is carried out using the Laplace-Adomian Decomposition Method(LADM),chosen for its efficiency and accuracy in solving high-order nonlinear partial differential equations.The numerical scheme successfully recovers both solitary and shock wave solutions under the sixth-order model,with error analysis confirming remarkably low numerical deviations.These results underscore the robustness of the method while demonstrating the profound contrast between shallow water wave dynamics without and with surface tension.展开更多
Near-surface geological defects pose a serious threat to human life and infrastructure.Hence,the exploration of geological hazards is essential.Currently,there are various geological hazard exploration methods;however...Near-surface geological defects pose a serious threat to human life and infrastructure.Hence,the exploration of geological hazards is essential.Currently,there are various geological hazard exploration methods;however,those require improvements in terms of economic feasibility,convenience,and lateral resolution.To address this,this study examined an extraction method to determine spatial autocorrelation velocity dispersion curves for application in near-surface exploration.展开更多
This study explores the complex dynamics of unsteady convective flow in micropolar nanofluids over a rough conical surface, with a focus on the effects of triple diffusive transport and Arrhenius activation energy. Th...This study explores the complex dynamics of unsteady convective flow in micropolar nanofluids over a rough conical surface, with a focus on the effects of triple diffusive transport and Arrhenius activation energy. The primary objective is to understand the interplay among nonlinear convection, micro-rotation effects, and species diffusion under the influence of thermal and electromagnetic forces. The analysis is motivated by practical applications of cryogenic fluids, specifically liquid hydrogen and liquid nitrogen,where precise control of heat and mass transport is critical. The conical surface roughness is mathematically modeled as a high-frequency, small-amplitude sinusoidal waveform.To address the non-similar nature of the boundary-layer equations, Mangler's transformations are employed, followed by the implementation of a finite difference scheme for numerical solutions. The methodology further integrates a machine learning-based neural network to predict the skin friction under the influence of roughness-induced perturbations, ensuring computational efficiency and improved generalization. The study yields several novel findings. Notably, the presence of surface roughness introduces the wavelike modulations in the local skin friction coefficient. It is also observed that nonlinear convective interactions, enhanced by temperature gradients and vortex viscosity parameters, significantly intensify near-wall velocity gradients. Moreover, key physical quantities are correlated with governing parameters using power-law relationships, providing generalized predictive models. The validation of the numerical results is achieved through consistency checks with the existing limiting solutions and convergence analysis, ensuring the reliability of the proposed computational framework.展开更多
In this paper,a generalized nth-order perturbation method based on the isogeometric boundary element method is proposed for the uncertainty analysis of broadband structural acoustic scattering problems.The Burton-Mill...In this paper,a generalized nth-order perturbation method based on the isogeometric boundary element method is proposed for the uncertainty analysis of broadband structural acoustic scattering problems.The Burton-Miller method is employed to solve the problem of non-unique solutions that may be encountered in the external acoustic field,and the nth-order discretization formulation of the boundary integral equation is derived.In addition,the computation of loop subdivision surfaces and the subdivision rules are introduced.In order to confirm the effectiveness of the algorithm,the computed results are contrasted and analyzed with the results under Monte Carlo simulations(MCs)through several numerical examples.展开更多
In three-dimensional free-bending forming(3D-FBF),the tube is not overly constrained,and the plastic deformation behavior and forming quality of the bent tube are significantly affected by the critical structure of th...In three-dimensional free-bending forming(3D-FBF),the tube is not overly constrained,and the plastic deformation behavior and forming quality of the bent tube are significantly affected by the critical structure of the forming die lining.However,the effects of die-lining structural parameters on the tube quality,and a method to determine the combination of die-lining structural parameters is yet to be devised.This study aims to propose a new framework that allows one to understand the effects of various die-lining structural parameters on tube quality and to propose the best combination of die-lining structural parameters.First,finite-element modeling is performed to simulate 3D-FBF and examine the effects of individual die-lining structures on the quality of tube formation.The simulation results show that the deformation-zone length and die gap are positively correlated with the tube-section distortion and wall-thickness variation,whereas it shows an opposite trend with respect to the bending radius.Additionally,the lining chamfer radius of the bending die and the guide lining chamfer radius minimally affect the tube forming quality.Subsequently,the optimal die-lining structure is obtained using the response-surface method.The tube cross-sectional distortion rate reduced from 2.73 to 2.53%after the die lining is optimized.Additionally,the average inner-wall thickness reduced to 1.06 mm,whereas the average outer-wall thickness increased to 0.97 mm.This paper proposes a method for optimizing the forming-die-lining mechanism and for improving the tube forming quality in 3D-FBF.展开更多
This research introduces a novel approach to enhancing bucket elevator design and operation through the integration of discrete element method(DEM)simulation,design of experiments(DOE),and metaheuristic optimization a...This research introduces a novel approach to enhancing bucket elevator design and operation through the integration of discrete element method(DEM)simulation,design of experiments(DOE),and metaheuristic optimization algorithms.Specifically,the study employs the firefly algorithm(FA),a metaheuristic optimization technique,to optimize bucket elevator parameters for maximizing transport mass and mass flow rate discharge of granular materials under specified working conditions.The experimental methodology involves several key steps:screening experiments to identify significant factors affecting bucket elevator operation,central composite design(CCD)experiments to further explore these factors,and response surface methodology(RSM)to create predictive models for transport mass and mass flow rate discharge.The FA algorithm is then applied to optimize these models,and the results are validated through simulation and empirical experiments.The study validates the optimized parameters through simulation and empirical experiments,comparing results with DEM simulation.The outcomes demonstrate the effectiveness of the FA algorithm in identifying optimal bucket parameters,showcasing less than 10%and 15%deviation for transport mass and mass flow rate discharge,respectively,between predicted and actual values.Overall,this research provides insights into the critical factors influencing bucket elevator operation and offers a systematic methodology for optimizing bucket parameters,contributing to more efficient material handling in various industrial applications.展开更多
The objectives of this present investigation were to develop and formulate nimesulide bilayer tablets by using different polymer combinations and fillers, to optimize the formulations for different drug release variab...The objectives of this present investigation were to develop and formulate nimesulide bilayer tablets by using different polymer combinations and fillers, to optimize the formulations for different drug release variables by orthogonal design and central composite design-surface methodology and to evaluate drug release pattern of the optimized product. The bilayer tablet containing a fast release layer（FRL） and a sustained release layer（SRL） provided an initial burst release of nimesulide, followed by the sustained release for a period of time. The optimal formulation obtained was as follows：（I） the formulation of FRL： nimesulide, 50 mg; lactose, 92 mg; starch, 22 mg; CCMC-Na, 14 mg; PVP K30, 1 mg; micronized silica gel, 1 mg; magnesium stearate, 0.9 mg; and iron oxide red, 0.1 mg; and（II） the formulation of SRL： nimesulide, 150 mg; HPMC K100LV, 26 mg; HPMC K4M, 33 mg; lactose, 54 mg; PVP K30, 1 mg; micronized silica gel, 1 mg; and magnesium stearate, 0.9 mg. According to the optimal formulation, the biphasic type of release was identified. The in vitro drug dissolution from the bilayer tablets was sustained for about 16 h after releasing 15% of drug in the first 10 min. The developed nimesulide bilayer tablets with improved efficacy can perform therapeutically better than the conventional tablets.展开更多
基金Supported by Special Item for Guangxi Bagui Scholars(Guicaijiaohan [2017]143)
文摘[Objectives] The research aimed to optimize extraction process of Clerodendrum philippinum Schauer var. simplex Mlodenke total flavonoids( CPTF),and provide reference for its development and utilization. [Methods] Based on single-factor test,ethanol concentration,extraction temperature and extraction time were taken as independent variables,and total flavonoids yield was taken as dependent variable. The test was conducted according to central composite design principle. Multivariate linear regression and binomial equation fitting of the result were conducted,and extraction process of CPTF was optimized by using response surface methodology. [Results]The optimal extraction process of CPTF was as below: ethanol concentration 54. 76%,extraction temperature 83. 92℃,extraction time 102. 64 min,solid-liquid ratio 1:20,extraction for twice. [Conclusions] The extraction process of CPTF by central composite design-response surface methodology was simple and feasible,with reliable prediction result,which was suitable for industrial production.
基金Supported by Key Scientific and Technological Planning Project of Guangxi(Gui Ke Neng 10100027-4)
文摘[Objectives]To optimize extraction process of total flavonoids from Akebia trifoliata( Thunb.) Koidz.,so as to provide references for development and use of Akebia trifoliata( Thunb.) Koidz. [Methods]The extraction rate of total flavonoids of Akebia trifoliata( Thunb.)Koidz. was taken as observation indicator. On the basis of single factor experiment,central composite design( CCD) was used to evaluate the effects of the extraction temperature,extraction time,and ethanol concentration on the extraction process. Multiple linear regression and binomial fitting were used,and response surface methodology( RSM) was used to select the optimum extraction process. [Results] The optimum extraction process conditions for total flavonoids of Akebia trifoliata( Thunb.) Koidz. was extraction temperature: 83. 92 ℃; extraction time:96. 47 min; ethanol concentration: 63. 92%; extraction times: two times; solid to liquid ratio: 1 ∶ 20; extraction rate of total flavonoids:4. 55%. [Conclusions] The central composite design-response surface methodology( CCD-RSM) is simple,convenient,and feasible for extraction of total flavonoids from Akebia trifoliata( Thunb.) Koidz.,and the prediction results are reliable.
基金supported by the National Key Research and Development Program of China(Grant No.2021YFB1714600)the National Natural Science Foundation of China(Grant No.52175095)the Young Top-Notch Talent Cultivation Program of Hubei Province of China.
文摘This paper examined how microstructure influences the homogenized thermal conductivity of cellular structures and revealed a surface-induced size-dependent effect.This effect is linked to the porous microstructural features of cellular structures,which stems from the degree of porosity and the distri-bution of the pores.Unlike the phonon-driven surface effect at the nanoscale,the macro-scale surface mechanism in thermal cellular structures is found to be the microstructure-induced changes in the heat conduction path based on fully resolved 3D numerical simulations.The surface region is determined by the microstructure,characterized by the intrinsic length.With the coupling between extrinsic and intrinsic length scales under the surface mechanism,a surface-enriched multiscale method was devel-oped to accurately capture the complex size-dependent thermal conductivity.The principle of scale separation required by classical multiscale methods is not necessary to be satisfied by the proposed multiscale method.The significant potential of the surface-enriched multiscale method was demon-strated through simulations of the effective thermal conductivity of a thin-walled metamaterial struc-ture.The surface-enriched multiscale method offers higher accuracy compared with the classical multiscale method and superior efficiency over high-fidelity finite element methods.
基金Supported by the National Natural Science Foundation of China(32072352)。
文摘In order to improve the quality of 3D printed raspberry preserves after post-processing,microwave ovens combining infrared and microwave methods were utilized.The effects of infrared heating temperature,infrared heating time,microwave power,microwave heating time on the center temperature,moisture content,the chroma(C*),the total color difference(ΔE*),shape fidelity,hardness,and the total anthocyanin content of 3D printed raspberry preserves were analyzed by response surface method(RSM).The results showed that under combining with the two methods,infrared heating improved the fidelity and quality degradation of printed products,while microwave heating enhanced the efficiency of infrared heating.Infrared-microwave combination cooking could maintain relatively stable color appearance and shape of 3D printed raspberry preserves.The AHP–CRITIC hybrid weighting method combined with the response surface test to determine the comprehensive weights of the evaluation indicators optimized the process parameters,and the optimal process parameters were obtained:infrared heating temperature of 190℃,infrared heating time of 10 min and 30 s,microwave power of 300 W,and microwave heating time of 2 min and 6 s.The 3D printed raspberry cooking methods obtained under the optimal conditions seldom had color variation,porous structure,uniform texture,and high shape fidelity,which retained the characteristics of personalized manufacturing by 3D printing.This study could provide a reference for the postprocessing and quality control of 3D cooking methods.
基金supported by the National Key Research and Development Program of China(2022YFA1203602)the National Natural Science Foundation of China(Grant No.12025206)+1 种基金the Strategic Priority Research Program of the Chinese Academy of Sciences(Grant No.XDB0620101)the National Natural Science Foundations of China(Grant No.12202366).
文摘Anode-free lithium metal batteries are prone to capacity degradation and safety hazards due to the formation and growth of lithium dendrites.The interface between the current collector and deposited lithium plays a critical role in preventing dendrite formation by regulating the thermodynamics and kinetics of lithium deposition.In this study,we develop a phase field model to investigate the influence of the current collector’s surface energy on lithium deposition morphology and its effect on the quality of the lithium metal film.It is demonstrated that a higher surface energy of the current collector promotes the growth of lithium metal along the surface of the current collector.Further,our simulation results show that a higher surface energy accelerates the formation of the lithium metal film while simultaneously reducing its surface roughness.By examining different contact angles and applied potentials,we construct a phase diagram of deposition morphology,illustrating that increased surface energy facilitates the dense and uniform deposition of lithium metal by preventing the formation of lithium filaments and voids.These findings provide new insights into the development and application of anode-free lithium metal batteries.
基金Project(52278380)supported by the National Natural Science Foundation of ChinaProject(2023JJ30670)supported by the National Science Foundation of and Technology Major Project of Hunan Province,China。
文摘This study proposes an alternative calculation mode for stresses on the slip surface(SS).The calculation of the normal stress(NS)on the SS involves examining its composition and expanding its unknown using the Taylor series.This expansion enables the reasonable construction of a function describing the NS on the SS.Additionally,by directly incorporating the nonlinear Generalized Hoke-Brown(GHB)strength criterion and utilizing the slope factor of safety(FOS)definition,a function of the shear stress on the SS is derived.This function considers the mutual feedback mechanism between the NS and strength parameters of the SS.The stress constraints conditions are then introduced at both ends of the SS based on the spatial stress relation of one point.Determining the slope FOS and stress solution for the SS involves considering the mechanical equilibrium conditions and the stress constraint conditions satisfied by the sliding body.The proposed approach successfully simulates the tension-shear stress zone near the slope top and provides an intuitive description of the concentration effect of compression-shear stress of the SS near the slope toe.Furthermore,compared to other methods,the present method demonstrates superior processing capabilities for the embedded nonlinear GHB strength criterion.
文摘The aim of this study is to evaluate the uncertainty of 2πα and 2πβ surface emission rates using the windowless multiwire proportional counter method.This study used the Monte Carlo method (MCM) to validate the conventional Guide to the Expression of Uncertainty in Measurement (GUM) method.A dead time measurement model for the two-source method was established based on the characteristics of a single-channel measurement system,and the voltage threshold correction factor measurement function was indirectly obtained by fitting the threshold correction curve.The uncertainty in the surface emission rate was calculated using the GUM method and the law of propagation of uncertainty.The MCM provided clear definitions for each input quantity and its uncertainty distribution,and the simulation training was realized with a complete and complex mathematical model.The results of the surface emission rate uncertainty evaluation for four radioactive plane sources using both methods showed the uncertainty’s consistency E_(n)<0.070 for the comparison of each source,and the uncertainty results of the GUM were all lower than those of the MCM.However,the MCM has a more objective evaluation process and can serve as a validation tool for GUM results.
基金supported by the Jiangsu Funding Program for Excellent Postdoctoral Talent (Grant No.2023ZB397)the Project funded by China Postdoctoral Science Foundation (Grant No.2023M732986).
文摘Nanomaterials have garnered recognition for their notable surface effects and demonstration of superior mechanical properties.Previous studies on the surface effects of nanomaterials,employing the finite element method,often relied on simplified twodimensional models due to theoretical complexities.Consequently,these simplified models inadequately represent the mechanical properties of nanomaterials and fail to capture the substantial impact of surface effects,particularly the curvature dependence of nanosurfaces.This study applies the principle of minimum energy and leverages the Steigmann-Ogden surface theory of nanomaterials to formulate a novel finite element surface element that comprehensively accounts for surface effects.We conducted an analysis of the stress distribution and deformation characteristics of four typical 2D and 3D nanomaterial models.The accuracy of the developed surface element and finite element calculation method was verified through comparison with established references.The resulting finite element model provides a robust and compelling scientific approach for accurately predicting the mechanical performance of nanomaterials.
基金the support from the 2025 Henan Provincial Science and Technology Research Project,the Zhumadian 2023 Major Science and Technology Special Projectthe Postgraduate Education Reform and Quality Improvement Project of Henan Province.
文摘At present,noise reduction has become an urgent challenge across various fields.Whether in the context of household appliances in daily life or in the enhancement of stealth performance in military equipment,noise control technologies play a critical role.This study introduces a computational framework for simulating Helmholtz equationgoverned acoustic scattering using a boundary element method(BEM)integrated with Loop subdivision surfaces.By adopting the Loop subdivision scheme—a widely used computer-aided design(CAD)technique-the framework unifies geometric representation and physical field discretization,ensuring seamless compatibility with industrial CAD workflows.The core innovation lies in the novel integration of conditional generative adversarial networks(CGANs)into the subdivision surface BEM to assist and accelerate the numerical computation process.In this study,for the two cases examined,the results show that the CGAN-enhanced approach achieves substantial gains in computational efficiency without compromising accuracy.A hierarchical acceleration strategy is further proposed:the fast multipole method(FMM)first reduces baseline computational complexity,while CGAN-driven secondary acceleration and data augmentation enable real-time parameter exploration.Benchmark validations and practical engineering applications demonstrate the method’s robustness and scalability for large-scale structural-acoustic analysis.
文摘The precise computation of nanoelectromechanical switches’(NEMS)multi-physical interactions requires advanced numerical models and is a crucial part of the development of micro-and nano-systems.This paper presents a novel compound numerical method to study the instability of a functionally graded(FG)beam-type NEMS,considering surface elasticity effects as stated by Gurtin-Murdoch theory in an Euler-Bernoulli beam.The presented method is based on a combination of the Method of Adjoints(MoA)together with the Bézier-based multistep technique.By utilizing the MoA,a boundary value problem(BVP)is turned into an initial value problem(IVP).The resulting IVP is then solved by employing a cost-efficient multi-step process.It is demonstrated that the mentioned method can arrive at a high level of accuracy.Furthermore,it is revealed that the stability of the presented methodology is far better than that of other common multi-step methods,such as Adams-Bashforth,particularly at higher step sizes.Finally,the effects of axially functionally graded(FG)properties on the pull-in phenomenon and the main design parameters of NEMS,including the detachment length,are inspected.It was shown that the main parameter of design is the modulus of elasticity of the material,as Silver(Ag),which had better mechanical properties,showed almost a 6%improvement compared to aluminum(Al).However,by applying the correct amount of material with sturdier surface parameters,such as Aluminum(Al),at certain points,the nanobeams’functionality can be improved even further by around 1.5%.
基金supported by the National Natural Science Foundation of China(grant number:52006061)the Key R&D Program of Hunan Province(grant number:2024AQ2001)+2 种基金Scientific Research Program of Hunan Provincial Department of Education(grant number:22B0840)Natural Science Foundation of Hunan Province(grant number:2023JJ50483)Hunan University of Humanities,Science and Technology Graduate Student Research and Innovation Program(ZSCX2024Y06,ZSCX2024Y01).
文摘To address the challenges of poor surface quality and high energy consumption in marble cutting,this study introduces an auxiliary abrasive jet cutting technology enhanced by the use of polyacrylamide(PAM)as a dragreducing additive.The effects of feed rate(50-300 mm/min),polymer concentration(0-0.5 g/L),and nozzle spacing(4-12 mm)on kerf width and surface roughness are systematically investigated through an orthogonal experimental design.Results reveal that feed rate emerges as themost significant factor(p<0.01),followed by PAM concentration and nozzle spacing.The optimal set of parameters,comprising a 200 mm/min feed rate,0.3 g/L PAM concentration,and 6mmnozzle spacing,achieves the narrowest kerf width(0.867 mm)and the lowest surface roughness(10.220μm).Analysis of the underlying mechanisms demonstrates that PAMenhances the energy efficiency of the jet by suppressing turbulent pulsations and increasing fluid viscoelasticity,thereby minimizing energy loss during the cutting process.
基金funded by the National Natural Science Foundation of China(No.52275343)the Natural Science Foundation of Zhejiang Province(No.LY23E050003)+1 种基金Ningbo Youth Science and Technology Innovation Leading Talent Project(No.2023QL021)Smart Medicine and Engineering Interdisciplinary Innovation Project of Ningbo University(No.ZHYG001).
文摘Triply periodic minimal surface(TPMS)-based bone implants are an innovative approach in orthopedic implantology,offering customized solutions for bone defect repair and regeneration.This review comprehensively examines the current research landscape of TPMS-based bone implants,addressing key challenges and proposing future directions.It explores design strategies aimed at optimizing mechanical strength and enhancing biological integration,with a particular emphasis on TPMS structures.These design strategies include graded,hierarchical,and hybrid designs,each contributing to the overall functionality and performance of the implants.This review also highlights state-of-the-art fabrication technologies,particularly advancements in additive manufacturing(AM)techniques for creating metal-based,polymer-based,and ceramic-based bone implants.The ability to precisely control the architecture of TPMS structures using AM techniques is crucial for tailoring the mechanical and biological properties of such implants.Furthermore,this review critically evaluates the biological performance of TPMS implants,focusing on their potential to promote bone ingrowth and regeneration.Key factors,such as mechanical properties,permeability,and biocompatibility,are examined to determine the effectiveness of these implants in clinical applications.By synthesizing existing knowledge and proposing innovative research directions,this review underscores the transformative potential of TPMS-based bone implants in orthopedic surgery.The objective is to improve clinical outcomes and enhance patient care through advanced implant designs and manufacturing techniques.
基金co-supported by the National Natural Science Foundation of China(No.62003019)the Young Talents Support Program of Beihang University,China(No.YWF21-BJ-J-1180)。
文摘This paper addresses the Singular Optimal Control Problem(SOCP)for a surface-to-air missile with limited control,fully considering aerodynamic effects with a parabolic drag polar.This problem is an extension of the typical Goddard problem.First,the classical Legendre-Clebsch condition is applied to derive optimal conditions for the singular angle of attack,revealing that the missile turns by gravity along the singular arc.Second,the higher-order differentiation of the switching function provides the necessary conditions to determine the optimal thrust,expressed as linear functions of the costate variables.The vanishing coefficient determinant is then employed to decouple the control and costate variables,yielding the singular thrust solely dependent on state variables and identifying the singular surface.Moreover,the analytical singular control can be regarded as path constraints subject to the typical Optimal Control Problem(OCP),enabling the GPOPS-Ⅱ,a direct method framework that does not involve the singular condition,to solve the SOCP.Finally,three cases with different structures are presented to evaluate the performance of the proposed method.The results show that it takes a few steps to obtain the numerical optimal solution,which is consistent with the analytical solution derived from the calculus of variations,highlighting its great computational accuracy and effectiveness.
文摘This study presents a numerical investigation of shallow water wave dynamics with particular emphasis on the role of surface tension.In the absence of surface tension,shallow water waves are primarily driven by gravity and are well described by the classical Boussinesq equation,which incorporates fourth-order dispersion.Under this framework,solitary and shock waves arise through the balance of nonlinearity and gravity-induced dispersion,producing waveforms whose propagation speed,amplitude,and width depend largely on depth and initial disturbance.The resulting dynamics are comparatively smoother,with solitary waves maintaining coherent structures and shock waves displaying gradual transitions.When surface tension is incorporated,however,the dynamics become significantly richer.Surface tension introduces additional sixth-order dispersive terms into the governing equation,extending the classical model to the sixth-order Boussinesq equation.This higher-order dispersion modifies the balance between nonlinearity and dispersion,leading to sharper solitary wave profiles,altered shock structures,and a stronger sensitivity of wave stability to parametric variations.Surface tension effects also change the scaling laws for wave amplitude and velocity,producing conditions where solitary waves can narrow while maintaining large amplitudes,or where shock fronts steepen more rapidly compared to the tension-free case.These differences highlight how capillary forces,though often neglected in macroscopic wave studies,play a fundamental role in shaping dynamics at smaller scales or in systems with strong fluid–interface interactions.The analysis in this work is carried out using the Laplace-Adomian Decomposition Method(LADM),chosen for its efficiency and accuracy in solving high-order nonlinear partial differential equations.The numerical scheme successfully recovers both solitary and shock wave solutions under the sixth-order model,with error analysis confirming remarkably low numerical deviations.These results underscore the robustness of the method while demonstrating the profound contrast between shallow water wave dynamics without and with surface tension.
基金supported by the Henan Province science and technology research project(Grant No.242102321031)National Natural Science Foundation of China(grant numbers 42207200).
文摘Near-surface geological defects pose a serious threat to human life and infrastructure.Hence,the exploration of geological hazards is essential.Currently,there are various geological hazard exploration methods;however,those require improvements in terms of economic feasibility,convenience,and lateral resolution.To address this,this study examined an extraction method to determine spatial autocorrelation velocity dispersion curves for application in near-surface exploration.
基金the Deanship of Research and Graduate Studies at King Khalid University for funding this work through Large Research Project under grant number RGP2/111/46
文摘This study explores the complex dynamics of unsteady convective flow in micropolar nanofluids over a rough conical surface, with a focus on the effects of triple diffusive transport and Arrhenius activation energy. The primary objective is to understand the interplay among nonlinear convection, micro-rotation effects, and species diffusion under the influence of thermal and electromagnetic forces. The analysis is motivated by practical applications of cryogenic fluids, specifically liquid hydrogen and liquid nitrogen,where precise control of heat and mass transport is critical. The conical surface roughness is mathematically modeled as a high-frequency, small-amplitude sinusoidal waveform.To address the non-similar nature of the boundary-layer equations, Mangler's transformations are employed, followed by the implementation of a finite difference scheme for numerical solutions. The methodology further integrates a machine learning-based neural network to predict the skin friction under the influence of roughness-induced perturbations, ensuring computational efficiency and improved generalization. The study yields several novel findings. Notably, the presence of surface roughness introduces the wavelike modulations in the local skin friction coefficient. It is also observed that nonlinear convective interactions, enhanced by temperature gradients and vortex viscosity parameters, significantly intensify near-wall velocity gradients. Moreover, key physical quantities are correlated with governing parameters using power-law relationships, providing generalized predictive models. The validation of the numerical results is achieved through consistency checks with the existing limiting solutions and convergence analysis, ensuring the reliability of the proposed computational framework.
基金sponsored by the Graduate Student Research and Innovation Fund of Xinyang Normal University under No.2024KYJJ012.
文摘In this paper,a generalized nth-order perturbation method based on the isogeometric boundary element method is proposed for the uncertainty analysis of broadband structural acoustic scattering problems.The Burton-Miller method is employed to solve the problem of non-unique solutions that may be encountered in the external acoustic field,and the nth-order discretization formulation of the boundary integral equation is derived.In addition,the computation of loop subdivision surfaces and the subdivision rules are introduced.In order to confirm the effectiveness of the algorithm,the computed results are contrasted and analyzed with the results under Monte Carlo simulations(MCs)through several numerical examples.
基金Supported by Open Fund of Jiangsu Industrial Perception and Intelligent Manufacturing Equipment Engineering Research Center of China(Grant No.ZK21-05-04)National Natural Science Foundation of China(Grant Nos.52105360,52175328)+1 种基金Fundamental Research Funds for the Central Universities of China(Grant No.NS2022061)Prince Sattam bin Abdulaziz University of Saudi Arabia(Grant No.PSAU/2024/R/1446).
文摘In three-dimensional free-bending forming(3D-FBF),the tube is not overly constrained,and the plastic deformation behavior and forming quality of the bent tube are significantly affected by the critical structure of the forming die lining.However,the effects of die-lining structural parameters on the tube quality,and a method to determine the combination of die-lining structural parameters is yet to be devised.This study aims to propose a new framework that allows one to understand the effects of various die-lining structural parameters on tube quality and to propose the best combination of die-lining structural parameters.First,finite-element modeling is performed to simulate 3D-FBF and examine the effects of individual die-lining structures on the quality of tube formation.The simulation results show that the deformation-zone length and die gap are positively correlated with the tube-section distortion and wall-thickness variation,whereas it shows an opposite trend with respect to the bending radius.Additionally,the lining chamfer radius of the bending die and the guide lining chamfer radius minimally affect the tube forming quality.Subsequently,the optimal die-lining structure is obtained using the response-surface method.The tube cross-sectional distortion rate reduced from 2.73 to 2.53%after the die lining is optimized.Additionally,the average inner-wall thickness reduced to 1.06 mm,whereas the average outer-wall thickness increased to 0.97 mm.This paper proposes a method for optimizing the forming-die-lining mechanism and for improving the tube forming quality in 3D-FBF.
基金This research was funded by the Faculty of Engineering,King Mongkut’s University of Technology North Bangkok.Contract No.ENG-NEW-66-39.
文摘This research introduces a novel approach to enhancing bucket elevator design and operation through the integration of discrete element method(DEM)simulation,design of experiments(DOE),and metaheuristic optimization algorithms.Specifically,the study employs the firefly algorithm(FA),a metaheuristic optimization technique,to optimize bucket elevator parameters for maximizing transport mass and mass flow rate discharge of granular materials under specified working conditions.The experimental methodology involves several key steps:screening experiments to identify significant factors affecting bucket elevator operation,central composite design(CCD)experiments to further explore these factors,and response surface methodology(RSM)to create predictive models for transport mass and mass flow rate discharge.The FA algorithm is then applied to optimize these models,and the results are validated through simulation and empirical experiments.The study validates the optimized parameters through simulation and empirical experiments,comparing results with DEM simulation.The outcomes demonstrate the effectiveness of the FA algorithm in identifying optimal bucket parameters,showcasing less than 10%and 15%deviation for transport mass and mass flow rate discharge,respectively,between predicted and actual values.Overall,this research provides insights into the critical factors influencing bucket elevator operation and offers a systematic methodology for optimizing bucket parameters,contributing to more efficient material handling in various industrial applications.
基金Important National Science & Technology Specific Projects of China(Grant No.2012ZX09301003-001-009)
文摘The objectives of this present investigation were to develop and formulate nimesulide bilayer tablets by using different polymer combinations and fillers, to optimize the formulations for different drug release variables by orthogonal design and central composite design-surface methodology and to evaluate drug release pattern of the optimized product. The bilayer tablet containing a fast release layer（FRL） and a sustained release layer（SRL） provided an initial burst release of nimesulide, followed by the sustained release for a period of time. The optimal formulation obtained was as follows：（I） the formulation of FRL： nimesulide, 50 mg; lactose, 92 mg; starch, 22 mg; CCMC-Na, 14 mg; PVP K30, 1 mg; micronized silica gel, 1 mg; magnesium stearate, 0.9 mg; and iron oxide red, 0.1 mg; and（II） the formulation of SRL： nimesulide, 150 mg; HPMC K100LV, 26 mg; HPMC K4M, 33 mg; lactose, 54 mg; PVP K30, 1 mg; micronized silica gel, 1 mg; and magnesium stearate, 0.9 mg. According to the optimal formulation, the biphasic type of release was identified. The in vitro drug dissolution from the bilayer tablets was sustained for about 16 h after releasing 15% of drug in the first 10 min. The developed nimesulide bilayer tablets with improved efficacy can perform therapeutically better than the conventional tablets.
