[Objectives] The research aimed to optimize extraction process of Clerodendrum philippinum Schauer var. simplex Mlodenke total flavonoids( CPTF),and provide reference for its development and utilization. [Methods] Bas...[Objectives] The research aimed to optimize extraction process of Clerodendrum philippinum Schauer var. simplex Mlodenke total flavonoids( CPTF),and provide reference for its development and utilization. [Methods] Based on single-factor test,ethanol concentration,extraction temperature and extraction time were taken as independent variables,and total flavonoids yield was taken as dependent variable. The test was conducted according to central composite design principle. Multivariate linear regression and binomial equation fitting of the result were conducted,and extraction process of CPTF was optimized by using response surface methodology. [Results]The optimal extraction process of CPTF was as below: ethanol concentration 54. 76%,extraction temperature 83. 92℃,extraction time 102. 64 min,solid-liquid ratio 1:20,extraction for twice. [Conclusions] The extraction process of CPTF by central composite design-response surface methodology was simple and feasible,with reliable prediction result,which was suitable for industrial production.展开更多
[Objectives]To optimize extraction process of total flavonoids from Akebia trifoliata( Thunb.) Koidz.,so as to provide references for development and use of Akebia trifoliata( Thunb.) Koidz. [Methods]The extraction ra...[Objectives]To optimize extraction process of total flavonoids from Akebia trifoliata( Thunb.) Koidz.,so as to provide references for development and use of Akebia trifoliata( Thunb.) Koidz. [Methods]The extraction rate of total flavonoids of Akebia trifoliata( Thunb.)Koidz. was taken as observation indicator. On the basis of single factor experiment,central composite design( CCD) was used to evaluate the effects of the extraction temperature,extraction time,and ethanol concentration on the extraction process. Multiple linear regression and binomial fitting were used,and response surface methodology( RSM) was used to select the optimum extraction process. [Results] The optimum extraction process conditions for total flavonoids of Akebia trifoliata( Thunb.) Koidz. was extraction temperature: 83. 92 ℃; extraction time:96. 47 min; ethanol concentration: 63. 92%; extraction times: two times; solid to liquid ratio: 1 ∶ 20; extraction rate of total flavonoids:4. 55%. [Conclusions] The central composite design-response surface methodology( CCD-RSM) is simple,convenient,and feasible for extraction of total flavonoids from Akebia trifoliata( Thunb.) Koidz.,and the prediction results are reliable.展开更多
An unsteady numerical simulation is conducted to examine the dynamic runback characteristics of a water film flow driven by a boundary layer airflow over a solid surface pertinent to the dynamic glaze ice accretion pr...An unsteady numerical simulation is conducted to examine the dynamic runback characteristics of a water film flow driven by a boundary layer airflow over a solid surface pertinent to the dynamic glaze ice accretion process over aircraft wing surfaces.The multiphase flow simulation results of the wind-driven water runback(WDWR)flow are compared quantitatively with the experimental results in terms of the time-dependent variations of the water film thickness profiles and evolution of the front contact point of the runback water film flow.The underlying mechanism of the intermittent water runback behavior is elucidated by analyzing the time evolution of the airflow velocity and vorticity fields above the runback water film flow over the solid surface.To the best knowledge of the authors,the work presented here is the first successful attempt to numerically examine the transient runback characteristics of WDWR flows.It serves as an excellent benchmark case for the development of best practices to model the important micro-physical processes responsible for the transient water transport over aircraft wing surfaces.展开更多
The objectives of this present investigation were to develop and formulate nimesulide bilayer tablets by using different polymer combinations and fillers, to optimize the formulations for different drug release variab...The objectives of this present investigation were to develop and formulate nimesulide bilayer tablets by using different polymer combinations and fillers, to optimize the formulations for different drug release variables by orthogonal design and central composite design-surface methodology and to evaluate drug release pattern of the optimized product. The bilayer tablet containing a fast release layer（FRL） and a sustained release layer（SRL） provided an initial burst release of nimesulide, followed by the sustained release for a period of time. The optimal formulation obtained was as follows：（I） the formulation of FRL： nimesulide, 50 mg; lactose, 92 mg; starch, 22 mg; CCMC-Na, 14 mg; PVP K30, 1 mg; micronized silica gel, 1 mg; magnesium stearate, 0.9 mg; and iron oxide red, 0.1 mg; and（II） the formulation of SRL： nimesulide, 150 mg; HPMC K100LV, 26 mg; HPMC K4M, 33 mg; lactose, 54 mg; PVP K30, 1 mg; micronized silica gel, 1 mg; and magnesium stearate, 0.9 mg. According to the optimal formulation, the biphasic type of release was identified. The in vitro drug dissolution from the bilayer tablets was sustained for about 16 h after releasing 15% of drug in the first 10 min. The developed nimesulide bilayer tablets with improved efficacy can perform therapeutically better than the conventional tablets.展开更多
This paper examined how microstructure influences the homogenized thermal conductivity of cellular structures and revealed a surface-induced size-dependent effect.This effect is linked to the porous microstructural fe...This paper examined how microstructure influences the homogenized thermal conductivity of cellular structures and revealed a surface-induced size-dependent effect.This effect is linked to the porous microstructural features of cellular structures,which stems from the degree of porosity and the distri-bution of the pores.Unlike the phonon-driven surface effect at the nanoscale,the macro-scale surface mechanism in thermal cellular structures is found to be the microstructure-induced changes in the heat conduction path based on fully resolved 3D numerical simulations.The surface region is determined by the microstructure,characterized by the intrinsic length.With the coupling between extrinsic and intrinsic length scales under the surface mechanism,a surface-enriched multiscale method was devel-oped to accurately capture the complex size-dependent thermal conductivity.The principle of scale separation required by classical multiscale methods is not necessary to be satisfied by the proposed multiscale method.The significant potential of the surface-enriched multiscale method was demon-strated through simulations of the effective thermal conductivity of a thin-walled metamaterial struc-ture.The surface-enriched multiscale method offers higher accuracy compared with the classical multiscale method and superior efficiency over high-fidelity finite element methods.展开更多
In order to improve the quality of 3D printed raspberry preserves after post-processing,microwave ovens combining infrared and microwave methods were utilized.The effects of infrared heating temperature,infrared heati...In order to improve the quality of 3D printed raspberry preserves after post-processing,microwave ovens combining infrared and microwave methods were utilized.The effects of infrared heating temperature,infrared heating time,microwave power,microwave heating time on the center temperature,moisture content,the chroma(C*),the total color difference(ΔE*),shape fidelity,hardness,and the total anthocyanin content of 3D printed raspberry preserves were analyzed by response surface method(RSM).The results showed that under combining with the two methods,infrared heating improved the fidelity and quality degradation of printed products,while microwave heating enhanced the efficiency of infrared heating.Infrared-microwave combination cooking could maintain relatively stable color appearance and shape of 3D printed raspberry preserves.The AHP–CRITIC hybrid weighting method combined with the response surface test to determine the comprehensive weights of the evaluation indicators optimized the process parameters,and the optimal process parameters were obtained:infrared heating temperature of 190℃,infrared heating time of 10 min and 30 s,microwave power of 300 W,and microwave heating time of 2 min and 6 s.The 3D printed raspberry cooking methods obtained under the optimal conditions seldom had color variation,porous structure,uniform texture,and high shape fidelity,which retained the characteristics of personalized manufacturing by 3D printing.This study could provide a reference for the postprocessing and quality control of 3D cooking methods.展开更多
Anode-free lithium metal batteries are prone to capacity degradation and safety hazards due to the formation and growth of lithium dendrites.The interface between the current collector and deposited lithium plays a cr...Anode-free lithium metal batteries are prone to capacity degradation and safety hazards due to the formation and growth of lithium dendrites.The interface between the current collector and deposited lithium plays a critical role in preventing dendrite formation by regulating the thermodynamics and kinetics of lithium deposition.In this study,we develop a phase field model to investigate the influence of the current collector’s surface energy on lithium deposition morphology and its effect on the quality of the lithium metal film.It is demonstrated that a higher surface energy of the current collector promotes the growth of lithium metal along the surface of the current collector.Further,our simulation results show that a higher surface energy accelerates the formation of the lithium metal film while simultaneously reducing its surface roughness.By examining different contact angles and applied potentials,we construct a phase diagram of deposition morphology,illustrating that increased surface energy facilitates the dense and uniform deposition of lithium metal by preventing the formation of lithium filaments and voids.These findings provide new insights into the development and application of anode-free lithium metal batteries.展开更多
An advanced Actuator Surface Method(ASM)coupled with Computational Fluid Dynamics(CFD)is developed and applied to the complex unsteady aerodynamic simulation of helicopter.By introducing an improved three-dimensional ...An advanced Actuator Surface Method(ASM)coupled with Computational Fluid Dynamics(CFD)is developed and applied to the complex unsteady aerodynamic simulation of helicopter.By introducing an improved three-dimensional anisotropic Gaussian kernel,this method effectively addresses the severe aerodynamic load fluctuations commonly associated with traditional Virtual Blade Method(VBM)due to turbulent flow around blade elements.To manage the issues of regional shape and grid cell quantity variations caused by virtual blade sweeping,a universal hybrid grid generation strategy is established without body-fitted and disk interpolation grids,which enhances the computational stability at both blade elements and blade edges.Aerodynamic numerical simulations of helicopter are performed using this method,focusing on rotor/fuselage interaction dominated by rotor wake motion and fuselage blockage effects,Blade-Vortex Interaction(BVI)induced by tip vortices,and maneuvering flights involving collective pitch ramp increases.The results indicate that the advanced ASM demonstrates reliability and robustness in the simulation of complex unsteady flow fields around helicopter.Under similar computational accuracy,the advanced ASM improves computational efficiency by nearly 40 times compared to the oversetgrid-based full Blade-Resolved(B-R)method,and by 6 times compared to the VBM.It shows significant advantages when applied to complex full-aircraft interaction and maneuvering flight conditions that require substantial computational resources.展开更多
This study proposes an alternative calculation mode for stresses on the slip surface(SS).The calculation of the normal stress(NS)on the SS involves examining its composition and expanding its unknown using the Taylor ...This study proposes an alternative calculation mode for stresses on the slip surface(SS).The calculation of the normal stress(NS)on the SS involves examining its composition and expanding its unknown using the Taylor series.This expansion enables the reasonable construction of a function describing the NS on the SS.Additionally,by directly incorporating the nonlinear Generalized Hoke-Brown(GHB)strength criterion and utilizing the slope factor of safety(FOS)definition,a function of the shear stress on the SS is derived.This function considers the mutual feedback mechanism between the NS and strength parameters of the SS.The stress constraints conditions are then introduced at both ends of the SS based on the spatial stress relation of one point.Determining the slope FOS and stress solution for the SS involves considering the mechanical equilibrium conditions and the stress constraint conditions satisfied by the sliding body.The proposed approach successfully simulates the tension-shear stress zone near the slope top and provides an intuitive description of the concentration effect of compression-shear stress of the SS near the slope toe.Furthermore,compared to other methods,the present method demonstrates superior processing capabilities for the embedded nonlinear GHB strength criterion.展开更多
An effective optimization method for the shape/sizing design of composite wing structures is presented with satisfying weight-cutting results. After decoupling, a kind of two-layer cycled optimization strategy suitabl...An effective optimization method for the shape/sizing design of composite wing structures is presented with satisfying weight-cutting results. After decoupling, a kind of two-layer cycled optimization strategy suitable for these integrated shape/sizing optimization is obtained. The uniform design method is used to provide sample points, and approximation models for shape design variables. And the results of sizing optimization are construct- ed with the quadratic response surface method （QRSM）. The complex method based on QRSM is used to opti- mize the shape design variables and the criteria method is adopted to optimize the sizing design variables. Compared with the conventional method, the proposed algorithm is more effective and feasible for solving complex composite optimization problems and has good efficiency in weight cutting.展开更多
The aim of the present study was to optimize the supercritical CO_2 extraction conditions of icariin from Herba Epimedii by response surface method(RSM) and central composite design(CCD).A 3-factor,5-level CCD was use...The aim of the present study was to optimize the supercritical CO_2 extraction conditions of icariin from Herba Epimedii by response surface method(RSM) and central composite design(CCD).A 3-factor,5-level CCD was used for the optimization.Independent variables were extraction temperature,extraction pressure and entrainer flow rate.Dependent variable was yield ratio of icariin from Herba Epimedii.A two-order polynomial equation was fitted to the data.The results showed that the optimum extraction conditions were as follows:extraction temperature 46.5℃,extraction pressure 30.6 MPa,entrainer flow rate 3.3 mL/min.CCD/ RSM is convenient and highly predictive for optimizing the extraction process of icariin from Herba Epimedii.展开更多
A surface edge element method is proposed and implemented in the study ofelectromagnetic scattering fields of general targets. The basis functions for surfaces of arbitraryshape are derived according to the geometrica...A surface edge element method is proposed and implemented in the study ofelectromagnetic scattering fields of general targets. The basis functions for surfaces of arbitraryshape are derived according to the geometrical properties of each triangular patch. The proposedbasis functions are 3-D linear functions and the tangential components of the vectors are continuousas the traditional edge element method. Combined field integral equations (CFIE) that include bothelectrical field and magnetic field integral equations are used to model the electromagneticscattering of general dielectric targets. Special treatment for singularity is presented to enhancethe quality of numerical solutions. The proposed method is used to compute the scattering fieldsfrom various targets. Numerical results obtained by the proposed method are validated by resultsfrom other numerical methods.展开更多
Surface notches lower the stiffness of laminated strips, so they lower the buckling loads of the laminated strips, too. In this paper a new method is proposed to predict the buckling loads of the laminated strips with...Surface notches lower the stiffness of laminated strips, so they lower the buckling loads of the laminated strips, too. In this paper a new method is proposed to predict the buckling loads of the laminated strips with a surface notch. The theoretical and experimental results show that the buckling loads decrease as the depth or width of the surface notches increase; when the stacking sequence of the laminated strips is [0°/0°/+ θ/-θ/0°/0°/+θ/-θ] s , the buckling load decrease as θ increases. It proves that the method is reliable and significant.展开更多
Due to the size effects of rockfill materials, the settlement difference between numerical simulation and in situ monitoring of rockfill dams is a topic of general concern.The constitutive model parameters obtained fr...Due to the size effects of rockfill materials, the settlement difference between numerical simulation and in situ monitoring of rockfill dams is a topic of general concern.The constitutive model parameters obtained from laboratory triaxial tests often underestimate the deformation of high rockfill dams.Therefore, constitutive model parameters obtained by back analysis were used to calculate and predict the long-term deformation of rockfill dams.Instead of using artificial neural networks (ANNs), the response surface method (RSM) was employed to replace the finite element simulation used in the optimization iteration.Only 27 training samples were required for RSM, improving computational efficiency compared with ANN, which required 300 training samples.RSM can be used to describe the relationship between the constitutive model parameters and dam settlements.The inversion results of the Shuibuya concrete face rockfill dam (CFRD) show that the calculated settlements agree with the measured data, indicating the accuracy and efficiency of RSM.展开更多
Tooth modification technique is widely used in gear industry to improve the meshing performance of gearings. However, few of the present studies on tooth modification considers the influence of inevitable random error...Tooth modification technique is widely used in gear industry to improve the meshing performance of gearings. However, few of the present studies on tooth modification considers the influence of inevitable random errors on gear modification effects. In order to investigate the uncertainties of tooth modification amount variations on system＇s dynamic behaviors of a helical planetary gears, an analytical dynamic model including tooth modification parameters is proposed to carry out a deterministic analysis on the dynamics of a helical planetary gear. The dynamic meshing forces as well as the dynamic transmission errors of the sun-planet 1 gear pair with and without tooth modifications are computed and compared to show the effectiveness of tooth modifications on gear dynamics enhancement. By using response surface method, a fitted regression model for the dynamic transmission error（DTE） fluctuations is established to quantify the relationship between modification amounts and DTE fluctuations. By shifting the inevitable random errors arousing from manufacturing and installing process to tooth modification amount variations, a statistical tooth modification model is developed and a methodology combining Monte Carlo simulation and response surface method is presented for uncertainty analysis of tooth modifications. The uncertainly analysis reveals that the system＇s dynamic behaviors do not obey the normal distribution rule even though the design variables are normally distributed. In addition, a deterministic modification amount will not definitely achieve an optimal result for both static and dynamic transmission error fluctuation reduction simultaneously.展开更多
Surface low/distortion is one of the most challenging surface deflections that have a great effect on the exterior appearance of automobiles.Most studies on surface distortion/deflection have focused on evaluation and...Surface low/distortion is one of the most challenging surface deflections that have a great effect on the exterior appearance of automobiles.Most studies on surface distortion/deflection have focused on evaluation and visualization techniques,the research work on correction or prevention of surface low/distortion is limited,and there is no perfect surface low/distortion corrective method that can satisfy the needs of the engineering.A B-spline based geometry morphing algorithm is proposed and then a new program based on UG-NX platform is developed to modify the die face in the surface low/distortion areas.To verify this developed system,the experimental dies that can replicate the surface low/distortion phenomenon successfully is put to use.Five geometric variables are introduced to describe the basic geometry of typical depression features of automotive outer panels.The experimental dies are then designed to reflect various combinations of these geometric parameters.The stamping experiments are conducted on cold rolled grade 5（CR5） sheet steel and various static measurements,such as oil-stoning,laser scanner,etc,are performed to measure and record the surface low/distortions.Three approaches including good bearing,holds in blank and die face morphing that aim to correct low/distortions are tried out and surface low/distortions are observed in the specimen with reverse draw depth of 10 mm.The measurement results show that die morphing is a practical and effective method to correct the surface low/distortion.The correction method proposed can be used to minimize the occurrence of surface low/distortion in die manufacturing,which has certain reference significance to the correction of surface low/distortion.展开更多
A current based hybrid method （HM） is proposed which combines the method of moment （MOM） with the Kirchhoff approximation （KA） for the analysis of scattering interaction between a two-dimensional （2D） infinite...A current based hybrid method （HM） is proposed which combines the method of moment （MOM） with the Kirchhoff approximation （KA） for the analysis of scattering interaction between a two-dimensional （2D） infinitely long conducting target with arbitrary cross section and a one-dimensional （1D） Gaussian rough surface. The electromagnetic scattering region in the HM is split into KA region and MOM region. The electric field integral equation （EFIE） in MOM region （target） is derived, the computational time of the HM depends mainly on the number of unknowns of the target. The bistatic scattering coefficient for the infinitely long cylinder above the rough surface with Gaussian roughness spectrum is calculated, and the numerical results are compared and verified with those obtained by the conventional MOM, which shows the high efficiency of the HM. Finally, the influence of the size, location of the target, the rms height and correlation length of the rough surface on the bistatic scattering coefficient with different polarizations is discussed in detail.展开更多
Because of the randomness of many impact factors influencing the dynamic assembly relationship of complex machinery, the reliability analysis of dynamic assembly relationship needs to be accomplished considering the r...Because of the randomness of many impact factors influencing the dynamic assembly relationship of complex machinery, the reliability analysis of dynamic assembly relationship needs to be accomplished considering the randomness from a probabilistic perspective. To improve the accuracy and efficiency of dynamic assembly relationship reliability analysis, the mechanical dynamic assembly reliability（MDAR） theory and a distributed collaborative response surface method（DCRSM） are proposed. The mathematic model of DCRSM is established based on the quadratic response surface function, and verified by the assembly relationship reliability analysis of aeroengine high pressure turbine（HPT） blade-tip radial running clearance（BTRRC）. Through the comparison of the DCRSM, traditional response surface method（RSM） and Monte Carlo Method（MCM）, the results show that the DCRSM is not able to accomplish the computational task which is impossible for the other methods when the number of simulation is more than 100 000 times, but also the computational precision for the DCRSM is basically consistent with the MCM and improved by 0.40-4.63% to the RSM, furthermore, the computational efficiency of DCRSM is up to about 188 times of the MCM and 55 times of the RSM under 10000 times simulations. The DCRSM is demonstrated to be a feasible and effective approach for markedly improving the computational efficiency and accuracy of MDAR analysis. Thus, the proposed research provides the promising theory and method for the MDAR design and optimization, and opens a novel research direction of probabilistic analysis for developing the high-performance and high-reliability of aeroengine.展开更多
A modified cellular automata （CA） model of dynamic recrystallization （DRX） and a flow stress-based nucleation parameter identification method have been developed. In the method, the modified CA model, which takes ...A modified cellular automata （CA） model of dynamic recrystallization （DRX） and a flow stress-based nucleation parameter identification method have been developed. In the method, the modified CA model, which takes the role of deformation degree on nucleation behavior into consideration, is coupled with an adaptive response surface model （ARSM） to search for the optimum nucleation parameter. The DRX behavior of an oxygen free high conductivity （OFHC） copper with different initial grain sizes has been taken as an example to validate the model. Good agreement is found between the simulated and the experimental results, which demonstrates that the new method can effectively improve the simulation accuracy.展开更多
A response surface method was employed to study the effect of α-amylase concentration, hydrolysis temperature and time on the production of high protein glutinous rice flour(HPGRF). The suspension of glutinous rice f...A response surface method was employed to study the effect of α-amylase concentration, hydrolysis temperature and time on the production of high protein glutinous rice flour(HPGRF). The suspension of glutinous rice flour(15%) that contained 6.52% protein was gelatinized and subsequently hydrolyzed by thermostable α-amylase. The hydrolysis yielded 0.144–0.222 g/g HPGRF with 29.4%–45.4% protein content. Hydrolysis time exerted a significant effect, while enzyme concentration and hydrolysis temperature showed insignificant effect on the protein content and production yield of HPGRF. The result of response surface method showed that the optimum condition for the production of HPGRF that contained at least 36% protein was treating gelatinized 15% glutinous rice flour suspension with 0.90 Kilo Novo α-amylase Unit(KNU)/g α-amylase at 80 oC for 99 min. By carrying out the predicted hydrolysis condition, HPGRF with 35.9% protein and 61.8% carbohydrates was resulted. The process yielded 0.172 g/g HPGRF. HPGRF contained higher amount of essential amino acids compared to glutinous rice flour. HPGRF had higher solubility and lower swelling power, and also showed no pasting peak compared with glutinous rice flour.展开更多
基金Supported by Special Item for Guangxi Bagui Scholars(Guicaijiaohan [2017]143)
文摘[Objectives] The research aimed to optimize extraction process of Clerodendrum philippinum Schauer var. simplex Mlodenke total flavonoids( CPTF),and provide reference for its development and utilization. [Methods] Based on single-factor test,ethanol concentration,extraction temperature and extraction time were taken as independent variables,and total flavonoids yield was taken as dependent variable. The test was conducted according to central composite design principle. Multivariate linear regression and binomial equation fitting of the result were conducted,and extraction process of CPTF was optimized by using response surface methodology. [Results]The optimal extraction process of CPTF was as below: ethanol concentration 54. 76%,extraction temperature 83. 92℃,extraction time 102. 64 min,solid-liquid ratio 1:20,extraction for twice. [Conclusions] The extraction process of CPTF by central composite design-response surface methodology was simple and feasible,with reliable prediction result,which was suitable for industrial production.
基金Supported by Key Scientific and Technological Planning Project of Guangxi(Gui Ke Neng 10100027-4)
文摘[Objectives]To optimize extraction process of total flavonoids from Akebia trifoliata( Thunb.) Koidz.,so as to provide references for development and use of Akebia trifoliata( Thunb.) Koidz. [Methods]The extraction rate of total flavonoids of Akebia trifoliata( Thunb.)Koidz. was taken as observation indicator. On the basis of single factor experiment,central composite design( CCD) was used to evaluate the effects of the extraction temperature,extraction time,and ethanol concentration on the extraction process. Multiple linear regression and binomial fitting were used,and response surface methodology( RSM) was used to select the optimum extraction process. [Results] The optimum extraction process conditions for total flavonoids of Akebia trifoliata( Thunb.) Koidz. was extraction temperature: 83. 92 ℃; extraction time:96. 47 min; ethanol concentration: 63. 92%; extraction times: two times; solid to liquid ratio: 1 ∶ 20; extraction rate of total flavonoids:4. 55%. [Conclusions] The central composite design-response surface methodology( CCD-RSM) is simple,convenient,and feasible for extraction of total flavonoids from Akebia trifoliata( Thunb.) Koidz.,and the prediction results are reliable.
基金supported by the National Science Foundation(NSF)of the USA(Grant Nos.TIP-2140489,CBET-2313310,and CBET-2415347).
文摘An unsteady numerical simulation is conducted to examine the dynamic runback characteristics of a water film flow driven by a boundary layer airflow over a solid surface pertinent to the dynamic glaze ice accretion process over aircraft wing surfaces.The multiphase flow simulation results of the wind-driven water runback(WDWR)flow are compared quantitatively with the experimental results in terms of the time-dependent variations of the water film thickness profiles and evolution of the front contact point of the runback water film flow.The underlying mechanism of the intermittent water runback behavior is elucidated by analyzing the time evolution of the airflow velocity and vorticity fields above the runback water film flow over the solid surface.To the best knowledge of the authors,the work presented here is the first successful attempt to numerically examine the transient runback characteristics of WDWR flows.It serves as an excellent benchmark case for the development of best practices to model the important micro-physical processes responsible for the transient water transport over aircraft wing surfaces.
基金Important National Science & Technology Specific Projects of China(Grant No.2012ZX09301003-001-009)
文摘The objectives of this present investigation were to develop and formulate nimesulide bilayer tablets by using different polymer combinations and fillers, to optimize the formulations for different drug release variables by orthogonal design and central composite design-surface methodology and to evaluate drug release pattern of the optimized product. The bilayer tablet containing a fast release layer（FRL） and a sustained release layer（SRL） provided an initial burst release of nimesulide, followed by the sustained release for a period of time. The optimal formulation obtained was as follows：（I） the formulation of FRL： nimesulide, 50 mg; lactose, 92 mg; starch, 22 mg; CCMC-Na, 14 mg; PVP K30, 1 mg; micronized silica gel, 1 mg; magnesium stearate, 0.9 mg; and iron oxide red, 0.1 mg; and（II） the formulation of SRL： nimesulide, 150 mg; HPMC K100LV, 26 mg; HPMC K4M, 33 mg; lactose, 54 mg; PVP K30, 1 mg; micronized silica gel, 1 mg; and magnesium stearate, 0.9 mg. According to the optimal formulation, the biphasic type of release was identified. The in vitro drug dissolution from the bilayer tablets was sustained for about 16 h after releasing 15% of drug in the first 10 min. The developed nimesulide bilayer tablets with improved efficacy can perform therapeutically better than the conventional tablets.
基金supported by the National Key Research and Development Program of China(Grant No.2021YFB1714600)the National Natural Science Foundation of China(Grant No.52175095)the Young Top-Notch Talent Cultivation Program of Hubei Province of China.
文摘This paper examined how microstructure influences the homogenized thermal conductivity of cellular structures and revealed a surface-induced size-dependent effect.This effect is linked to the porous microstructural features of cellular structures,which stems from the degree of porosity and the distri-bution of the pores.Unlike the phonon-driven surface effect at the nanoscale,the macro-scale surface mechanism in thermal cellular structures is found to be the microstructure-induced changes in the heat conduction path based on fully resolved 3D numerical simulations.The surface region is determined by the microstructure,characterized by the intrinsic length.With the coupling between extrinsic and intrinsic length scales under the surface mechanism,a surface-enriched multiscale method was devel-oped to accurately capture the complex size-dependent thermal conductivity.The principle of scale separation required by classical multiscale methods is not necessary to be satisfied by the proposed multiscale method.The significant potential of the surface-enriched multiscale method was demon-strated through simulations of the effective thermal conductivity of a thin-walled metamaterial struc-ture.The surface-enriched multiscale method offers higher accuracy compared with the classical multiscale method and superior efficiency over high-fidelity finite element methods.
基金Supported by the National Natural Science Foundation of China(32072352)。
文摘In order to improve the quality of 3D printed raspberry preserves after post-processing,microwave ovens combining infrared and microwave methods were utilized.The effects of infrared heating temperature,infrared heating time,microwave power,microwave heating time on the center temperature,moisture content,the chroma(C*),the total color difference(ΔE*),shape fidelity,hardness,and the total anthocyanin content of 3D printed raspberry preserves were analyzed by response surface method(RSM).The results showed that under combining with the two methods,infrared heating improved the fidelity and quality degradation of printed products,while microwave heating enhanced the efficiency of infrared heating.Infrared-microwave combination cooking could maintain relatively stable color appearance and shape of 3D printed raspberry preserves.The AHP–CRITIC hybrid weighting method combined with the response surface test to determine the comprehensive weights of the evaluation indicators optimized the process parameters,and the optimal process parameters were obtained:infrared heating temperature of 190℃,infrared heating time of 10 min and 30 s,microwave power of 300 W,and microwave heating time of 2 min and 6 s.The 3D printed raspberry cooking methods obtained under the optimal conditions seldom had color variation,porous structure,uniform texture,and high shape fidelity,which retained the characteristics of personalized manufacturing by 3D printing.This study could provide a reference for the postprocessing and quality control of 3D cooking methods.
基金supported by the National Key Research and Development Program of China(2022YFA1203602)the National Natural Science Foundation of China(Grant No.12025206)+1 种基金the Strategic Priority Research Program of the Chinese Academy of Sciences(Grant No.XDB0620101)the National Natural Science Foundations of China(Grant No.12202366).
文摘Anode-free lithium metal batteries are prone to capacity degradation and safety hazards due to the formation and growth of lithium dendrites.The interface between the current collector and deposited lithium plays a critical role in preventing dendrite formation by regulating the thermodynamics and kinetics of lithium deposition.In this study,we develop a phase field model to investigate the influence of the current collector’s surface energy on lithium deposition morphology and its effect on the quality of the lithium metal film.It is demonstrated that a higher surface energy of the current collector promotes the growth of lithium metal along the surface of the current collector.Further,our simulation results show that a higher surface energy accelerates the formation of the lithium metal film while simultaneously reducing its surface roughness.By examining different contact angles and applied potentials,we construct a phase diagram of deposition morphology,illustrating that increased surface energy facilitates the dense and uniform deposition of lithium metal by preventing the formation of lithium filaments and voids.These findings provide new insights into the development and application of anode-free lithium metal batteries.
基金co-supported by the Foundation of the State Key Laboratory of Aerodynamics(No.RAL202203)the National Key Laboratory Foundation(No.6142202202)the China Postdoctoral Science Foundation(No.2024M754133)。
文摘An advanced Actuator Surface Method(ASM)coupled with Computational Fluid Dynamics(CFD)is developed and applied to the complex unsteady aerodynamic simulation of helicopter.By introducing an improved three-dimensional anisotropic Gaussian kernel,this method effectively addresses the severe aerodynamic load fluctuations commonly associated with traditional Virtual Blade Method(VBM)due to turbulent flow around blade elements.To manage the issues of regional shape and grid cell quantity variations caused by virtual blade sweeping,a universal hybrid grid generation strategy is established without body-fitted and disk interpolation grids,which enhances the computational stability at both blade elements and blade edges.Aerodynamic numerical simulations of helicopter are performed using this method,focusing on rotor/fuselage interaction dominated by rotor wake motion and fuselage blockage effects,Blade-Vortex Interaction(BVI)induced by tip vortices,and maneuvering flights involving collective pitch ramp increases.The results indicate that the advanced ASM demonstrates reliability and robustness in the simulation of complex unsteady flow fields around helicopter.Under similar computational accuracy,the advanced ASM improves computational efficiency by nearly 40 times compared to the oversetgrid-based full Blade-Resolved(B-R)method,and by 6 times compared to the VBM.It shows significant advantages when applied to complex full-aircraft interaction and maneuvering flight conditions that require substantial computational resources.
基金Project(52278380)supported by the National Natural Science Foundation of ChinaProject(2023JJ30670)supported by the National Science Foundation of and Technology Major Project of Hunan Province,China。
文摘This study proposes an alternative calculation mode for stresses on the slip surface(SS).The calculation of the normal stress(NS)on the SS involves examining its composition and expanding its unknown using the Taylor series.This expansion enables the reasonable construction of a function describing the NS on the SS.Additionally,by directly incorporating the nonlinear Generalized Hoke-Brown(GHB)strength criterion and utilizing the slope factor of safety(FOS)definition,a function of the shear stress on the SS is derived.This function considers the mutual feedback mechanism between the NS and strength parameters of the SS.The stress constraints conditions are then introduced at both ends of the SS based on the spatial stress relation of one point.Determining the slope FOS and stress solution for the SS involves considering the mechanical equilibrium conditions and the stress constraint conditions satisfied by the sliding body.The proposed approach successfully simulates the tension-shear stress zone near the slope top and provides an intuitive description of the concentration effect of compression-shear stress of the SS near the slope toe.Furthermore,compared to other methods,the present method demonstrates superior processing capabilities for the embedded nonlinear GHB strength criterion.
文摘An effective optimization method for the shape/sizing design of composite wing structures is presented with satisfying weight-cutting results. After decoupling, a kind of two-layer cycled optimization strategy suitable for these integrated shape/sizing optimization is obtained. The uniform design method is used to provide sample points, and approximation models for shape design variables. And the results of sizing optimization are construct- ed with the quadratic response surface method （QRSM）. The complex method based on QRSM is used to opti- mize the shape design variables and the criteria method is adopted to optimize the sizing design variables. Compared with the conventional method, the proposed algorithm is more effective and feasible for solving complex composite optimization problems and has good efficiency in weight cutting.
文摘The aim of the present study was to optimize the supercritical CO_2 extraction conditions of icariin from Herba Epimedii by response surface method(RSM) and central composite design(CCD).A 3-factor,5-level CCD was used for the optimization.Independent variables were extraction temperature,extraction pressure and entrainer flow rate.Dependent variable was yield ratio of icariin from Herba Epimedii.A two-order polynomial equation was fitted to the data.The results showed that the optimum extraction conditions were as follows:extraction temperature 46.5℃,extraction pressure 30.6 MPa,entrainer flow rate 3.3 mL/min.CCD/ RSM is convenient and highly predictive for optimizing the extraction process of icariin from Herba Epimedii.
文摘A surface edge element method is proposed and implemented in the study ofelectromagnetic scattering fields of general targets. The basis functions for surfaces of arbitraryshape are derived according to the geometrical properties of each triangular patch. The proposedbasis functions are 3-D linear functions and the tangential components of the vectors are continuousas the traditional edge element method. Combined field integral equations (CFIE) that include bothelectrical field and magnetic field integral equations are used to model the electromagneticscattering of general dielectric targets. Special treatment for singularity is presented to enhancethe quality of numerical solutions. The proposed method is used to compute the scattering fieldsfrom various targets. Numerical results obtained by the proposed method are validated by resultsfrom other numerical methods.
文摘Surface notches lower the stiffness of laminated strips, so they lower the buckling loads of the laminated strips, too. In this paper a new method is proposed to predict the buckling loads of the laminated strips with a surface notch. The theoretical and experimental results show that the buckling loads decrease as the depth or width of the surface notches increase; when the stacking sequence of the laminated strips is [0°/0°/+ θ/-θ/0°/0°/+θ/-θ] s , the buckling load decrease as θ increases. It proves that the method is reliable and significant.
基金supported by the National Natural Science Foundation of China(Grant No.51579193)the Science and Technology Planning Project of Guizhou Province(Grant No.[2016]1154)
文摘Due to the size effects of rockfill materials, the settlement difference between numerical simulation and in situ monitoring of rockfill dams is a topic of general concern.The constitutive model parameters obtained from laboratory triaxial tests often underestimate the deformation of high rockfill dams.Therefore, constitutive model parameters obtained by back analysis were used to calculate and predict the long-term deformation of rockfill dams.Instead of using artificial neural networks (ANNs), the response surface method (RSM) was employed to replace the finite element simulation used in the optimization iteration.Only 27 training samples were required for RSM, improving computational efficiency compared with ANN, which required 300 training samples.RSM can be used to describe the relationship between the constitutive model parameters and dam settlements.The inversion results of the Shuibuya concrete face rockfill dam (CFRD) show that the calculated settlements agree with the measured data, indicating the accuracy and efficiency of RSM.
基金Supported by National Natural Science Foundation of China(Grant No.51375013)Anhui Provincial Natural Science Foundation of China(Grant No.1208085ME64)
文摘Tooth modification technique is widely used in gear industry to improve the meshing performance of gearings. However, few of the present studies on tooth modification considers the influence of inevitable random errors on gear modification effects. In order to investigate the uncertainties of tooth modification amount variations on system＇s dynamic behaviors of a helical planetary gears, an analytical dynamic model including tooth modification parameters is proposed to carry out a deterministic analysis on the dynamics of a helical planetary gear. The dynamic meshing forces as well as the dynamic transmission errors of the sun-planet 1 gear pair with and without tooth modifications are computed and compared to show the effectiveness of tooth modifications on gear dynamics enhancement. By using response surface method, a fitted regression model for the dynamic transmission error（DTE） fluctuations is established to quantify the relationship between modification amounts and DTE fluctuations. By shifting the inevitable random errors arousing from manufacturing and installing process to tooth modification amount variations, a statistical tooth modification model is developed and a methodology combining Monte Carlo simulation and response surface method is presented for uncertainty analysis of tooth modifications. The uncertainly analysis reveals that the system＇s dynamic behaviors do not obey the normal distribution rule even though the design variables are normally distributed. In addition, a deterministic modification amount will not definitely achieve an optimal result for both static and dynamic transmission error fluctuation reduction simultaneously.
基金supported by Key Project of National Natural Science Foundation of China (Grant No. 10932003)National Hi-tech Research and Development Program of China (863 Program,Grant No.2009AA04Z101)National Basic Research Program of China (973Program,Grant No. 2010CB832700)
文摘Surface low/distortion is one of the most challenging surface deflections that have a great effect on the exterior appearance of automobiles.Most studies on surface distortion/deflection have focused on evaluation and visualization techniques,the research work on correction or prevention of surface low/distortion is limited,and there is no perfect surface low/distortion corrective method that can satisfy the needs of the engineering.A B-spline based geometry morphing algorithm is proposed and then a new program based on UG-NX platform is developed to modify the die face in the surface low/distortion areas.To verify this developed system,the experimental dies that can replicate the surface low/distortion phenomenon successfully is put to use.Five geometric variables are introduced to describe the basic geometry of typical depression features of automotive outer panels.The experimental dies are then designed to reflect various combinations of these geometric parameters.The stamping experiments are conducted on cold rolled grade 5（CR5） sheet steel and various static measurements,such as oil-stoning,laser scanner,etc,are performed to measure and record the surface low/distortions.Three approaches including good bearing,holds in blank and die face morphing that aim to correct low/distortions are tried out and surface low/distortions are observed in the specimen with reverse draw depth of 10 mm.The measurement results show that die morphing is a practical and effective method to correct the surface low/distortion.The correction method proposed can be used to minimize the occurrence of surface low/distortion in die manufacturing,which has certain reference significance to the correction of surface low/distortion.
基金Project supported by the National Natural Science Foundation of China (Grant No 60571058)the Specialized Research Fund for the Doctoral Program of Higher Education, China
文摘A current based hybrid method （HM） is proposed which combines the method of moment （MOM） with the Kirchhoff approximation （KA） for the analysis of scattering interaction between a two-dimensional （2D） infinitely long conducting target with arbitrary cross section and a one-dimensional （1D） Gaussian rough surface. The electromagnetic scattering region in the HM is split into KA region and MOM region. The electric field integral equation （EFIE） in MOM region （target） is derived, the computational time of the HM depends mainly on the number of unknowns of the target. The bistatic scattering coefficient for the infinitely long cylinder above the rough surface with Gaussian roughness spectrum is calculated, and the numerical results are compared and verified with those obtained by the conventional MOM, which shows the high efficiency of the HM. Finally, the influence of the size, location of the target, the rms height and correlation length of the rough surface on the bistatic scattering coefficient with different polarizations is discussed in detail.
基金supported by National Natural Science Foundation of China(Grant Nos.51175017,51245027)Innovation Foundation of Beihang University for PhD Graduates,China(Grant No.YWF-12-RBYJ008)Research Fund for the Doctoral Program of Higher Education of China(Grant No.20111102110011)
文摘Because of the randomness of many impact factors influencing the dynamic assembly relationship of complex machinery, the reliability analysis of dynamic assembly relationship needs to be accomplished considering the randomness from a probabilistic perspective. To improve the accuracy and efficiency of dynamic assembly relationship reliability analysis, the mechanical dynamic assembly reliability（MDAR） theory and a distributed collaborative response surface method（DCRSM） are proposed. The mathematic model of DCRSM is established based on the quadratic response surface function, and verified by the assembly relationship reliability analysis of aeroengine high pressure turbine（HPT） blade-tip radial running clearance（BTRRC）. Through the comparison of the DCRSM, traditional response surface method（RSM） and Monte Carlo Method（MCM）, the results show that the DCRSM is not able to accomplish the computational task which is impossible for the other methods when the number of simulation is more than 100 000 times, but also the computational precision for the DCRSM is basically consistent with the MCM and improved by 0.40-4.63% to the RSM, furthermore, the computational efficiency of DCRSM is up to about 188 times of the MCM and 55 times of the RSM under 10000 times simulations. The DCRSM is demonstrated to be a feasible and effective approach for markedly improving the computational efficiency and accuracy of MDAR analysis. Thus, the proposed research provides the promising theory and method for the MDAR design and optimization, and opens a novel research direction of probabilistic analysis for developing the high-performance and high-reliability of aeroengine.
基金supported by the National Basic Research Program of China (No. 2006CB705401)the National Natural Science Foundation of China (No.51075270)the Natural Science Foundation of the Jiangsu Higher Education Institutions of China (No.10KJD460003)
文摘A modified cellular automata （CA） model of dynamic recrystallization （DRX） and a flow stress-based nucleation parameter identification method have been developed. In the method, the modified CA model, which takes the role of deformation degree on nucleation behavior into consideration, is coupled with an adaptive response surface model （ARSM） to search for the optimum nucleation parameter. The DRX behavior of an oxygen free high conductivity （OFHC） copper with different initial grain sizes has been taken as an example to validate the model. Good agreement is found between the simulated and the experimental results, which demonstrates that the new method can effectively improve the simulation accuracy.
文摘A response surface method was employed to study the effect of α-amylase concentration, hydrolysis temperature and time on the production of high protein glutinous rice flour(HPGRF). The suspension of glutinous rice flour(15%) that contained 6.52% protein was gelatinized and subsequently hydrolyzed by thermostable α-amylase. The hydrolysis yielded 0.144–0.222 g/g HPGRF with 29.4%–45.4% protein content. Hydrolysis time exerted a significant effect, while enzyme concentration and hydrolysis temperature showed insignificant effect on the protein content and production yield of HPGRF. The result of response surface method showed that the optimum condition for the production of HPGRF that contained at least 36% protein was treating gelatinized 15% glutinous rice flour suspension with 0.90 Kilo Novo α-amylase Unit(KNU)/g α-amylase at 80 oC for 99 min. By carrying out the predicted hydrolysis condition, HPGRF with 35.9% protein and 61.8% carbohydrates was resulted. The process yielded 0.172 g/g HPGRF. HPGRF contained higher amount of essential amino acids compared to glutinous rice flour. HPGRF had higher solubility and lower swelling power, and also showed no pasting peak compared with glutinous rice flour.
