The floatation of the minerals diaspore and kaolinite was investigated using dodecylamine as the collector.Separating diaspore and kaolinite in a neutral pH pulp is difficult since they then have similar floatability....The floatation of the minerals diaspore and kaolinite was investigated using dodecylamine as the collector.Separating diaspore and kaolinite in a neutral pH pulp is difficult since they then have similar floatability.A depressor consisting of an AlCl3/Na2SiO3 mixture is demonstrated to solve this problem.Diaspore sinking may be seen when the ratio of AlCl3 to Na2SiO3 is 3:1.We refer to this mixture as ATNO.The influence of Al/Si ratio in the feedstock and the grain size of fed minerals on separation was examined.An Al/Si ratio in the concentrate greater than 11 may be obtained when the Al/Si ratio of the feed is between 2.53 and 4.96.However,the grain size of the diaspore greatly influences the concentrate grade.Finer grain size of the diaspore(<40 μm) in pulp makes the flotation separation less than ideal,no matter what the kaolinite grain size.展开更多
Metallic corrosion is a serious problem in the application of a hygroscopic inorganic dust-depressor. The basic characteristics of a hygroscopic inorganic dust-depressor and its corrosivity, corrosion mechanism, as we...Metallic corrosion is a serious problem in the application of a hygroscopic inorganic dust-depressor. The basic characteristics of a hygroscopic inorganic dust-depressor and its corrosivity, corrosion mechanism, as well as the principle of corrosion inhibition were analyzed. The static mass-loss test was carried out to investigate the corrosion behavior and the effect of the dust-depressor. The static corrosion rates of steel specimens were measured in six different corrosion inhibitor solutions of the dust-depressor, and the suitable corrosion inhibitors for the dust-depressor to reduce the corrosivity were found out.展开更多
根据《中华人民共和国药典》2020年版四部通则1145,降压物质检查是通过比较组胺对照品与供试品引起麻醉猫的血压下降程度,判定供试品中所含降压物质的限度是否符合规定的一项常见药品检验方法。当降压物质检查结果超过质量标准规定(out ...根据《中华人民共和国药典》2020年版四部通则1145,降压物质检查是通过比较组胺对照品与供试品引起麻醉猫的血压下降程度,判定供试品中所含降压物质的限度是否符合规定的一项常见药品检验方法。当降压物质检查结果超过质量标准规定(out of specification,OOS),可能是由药品本身质量风险引起,也可能是源于检验过程中的错误操作。因此,开展OOS原因分析对于确认试验结果、评价药品质量尤为重要。降压物质检查采用猫作为实验动物,其稳定性相对于常规实验动物更差,且手术难度大、试验流程复杂,这些因素导致调查降压物质检查出现OOS原因的难度较大。通过查阅资料结合实际工作经验,本文主要通过以下5方面分析降压物质检查出现OOS的原因:(1)从标准判定、标准内容以及标准起草3个方面分析了药品标准对OOS的影响;(2)人员资质,包括岗前培训、试验操作是否遵循标准操作规程,以及仪器操作的能力;(3)猫作为降压物质检查所用实验动物,其生理特性、遗传背景及试验过程中出现的异常状态等因素;(4)标准品、试剂、受试物以及关键仪器多道生理信号仪;(5)包括动物麻醉、动静脉插管手术、给药、数据处理等试验操作。本文旨在为广大药品与生物制品检验同行,在分析药品降压物质检查过程中出现OOS的原因时,提供一些参考思路。展开更多
基金support for this study obtained from the Funding Project for Academic Human Resources Development in Institutions of Higher Learning under the Jurisdiction of Beijing Municipality (No.PHR 200906210)Funding Project for Base Construction of Scientific Research of Beijing Municipal Commission of Education (No.WYJD200902)Funding Project for Science and Technology Program of Beijing Municipal Commission of Education (No.KM 200810037001) is gratefully acknowledged
文摘The floatation of the minerals diaspore and kaolinite was investigated using dodecylamine as the collector.Separating diaspore and kaolinite in a neutral pH pulp is difficult since they then have similar floatability.A depressor consisting of an AlCl3/Na2SiO3 mixture is demonstrated to solve this problem.Diaspore sinking may be seen when the ratio of AlCl3 to Na2SiO3 is 3:1.We refer to this mixture as ATNO.The influence of Al/Si ratio in the feedstock and the grain size of fed minerals on separation was examined.An Al/Si ratio in the concentrate greater than 11 may be obtained when the Al/Si ratio of the feed is between 2.53 and 4.96.However,the grain size of the diaspore greatly influences the concentrate grade.Finer grain size of the diaspore(<40 μm) in pulp makes the flotation separation less than ideal,no matter what the kaolinite grain size.
文摘Metallic corrosion is a serious problem in the application of a hygroscopic inorganic dust-depressor. The basic characteristics of a hygroscopic inorganic dust-depressor and its corrosivity, corrosion mechanism, as well as the principle of corrosion inhibition were analyzed. The static mass-loss test was carried out to investigate the corrosion behavior and the effect of the dust-depressor. The static corrosion rates of steel specimens were measured in six different corrosion inhibitor solutions of the dust-depressor, and the suitable corrosion inhibitors for the dust-depressor to reduce the corrosivity were found out.
文摘根据《中华人民共和国药典》2020年版四部通则1145,降压物质检查是通过比较组胺对照品与供试品引起麻醉猫的血压下降程度,判定供试品中所含降压物质的限度是否符合规定的一项常见药品检验方法。当降压物质检查结果超过质量标准规定(out of specification,OOS),可能是由药品本身质量风险引起,也可能是源于检验过程中的错误操作。因此,开展OOS原因分析对于确认试验结果、评价药品质量尤为重要。降压物质检查采用猫作为实验动物,其稳定性相对于常规实验动物更差,且手术难度大、试验流程复杂,这些因素导致调查降压物质检查出现OOS原因的难度较大。通过查阅资料结合实际工作经验,本文主要通过以下5方面分析降压物质检查出现OOS的原因:(1)从标准判定、标准内容以及标准起草3个方面分析了药品标准对OOS的影响;(2)人员资质,包括岗前培训、试验操作是否遵循标准操作规程,以及仪器操作的能力;(3)猫作为降压物质检查所用实验动物,其生理特性、遗传背景及试验过程中出现的异常状态等因素;(4)标准品、试剂、受试物以及关键仪器多道生理信号仪;(5)包括动物麻醉、动静脉插管手术、给药、数据处理等试验操作。本文旨在为广大药品与生物制品检验同行,在分析药品降压物质检查过程中出现OOS的原因时,提供一些参考思路。
