All living cells in a human body are made of the same DNA molecule but cells in different tissues express different genes and proteins.How the transcription process is controlled and regulated is largely unknown.Speci...All living cells in a human body are made of the same DNA molecule but cells in different tissues express different genes and proteins.How the transcription process is controlled and regulated is largely unknown.Specifically,mechanical forces are increasingly recognized to play critical roles in cell and tissue functions.However,what controls force-induced gene transcription is elusive.Recently we have reported that a local surface force transfers from integrins to the cytoskeleton and the link of nucleoskeleton and the cytoskeleton(LINC)into the nucleus and deforms chromatin directly to induce rapid activation of transgene DHFR.Here we show that endogenous mechanoresponsive genes egr-1 and Cav1 are rapidly upregulated and their upregulation depends on stress angles relative to the cell long axis,suggesting direct impact of these genes by force.Demethylation of histone 3 at lysine 9(H3K9)trimethylation(H3K9me3)at nuclear interiors(euchromatin)is necessary for force-induced transcription upregulation.Our findings suggest that force-rapid upregulation of mechanoresponsive genes by force depends on H3K9me3 demethylation.展开更多
The success of the fruit fly Drosophila melanogaster as a model organism is heavily attributed to the expansive range and multitude of genetic and molecular tools available to modify gene expression at will. The GaI4/...The success of the fruit fly Drosophila melanogaster as a model organism is heavily attributed to the expansive range and multitude of genetic and molecular tools available to modify gene expression at will. The GaI4/UAS binary system is one of the most important and widely used genetic tools in Drosophila designed for targeted gene expression （Brand and Perrimon, 1993）, which allows ectopic expression of any gene （or transgene） in specific tissues, independent of their native regulators. However, a drawback of the original UASt-transgene is its silence in germline cells--when the UASt-RFPhis transgene was driven by a ubiquitously expressed 6al4 under the ActinSC promoter （act-Gal4）, RFP expression was only detected in the somatic follicle cells, but not in the germline nurse cells or the oocyte （Fig. 1A）.展开更多
Mao Yushi is a well known economist, academic, and speaker on Chinese macro-economic issues. His ideas on entrepreneurship, morality, and the law in China’s economic system has garnered him national recognition, whil...Mao Yushi is a well known economist, academic, and speaker on Chinese macro-economic issues. His ideas on entrepreneurship, morality, and the law in China’s economic system has garnered him national recognition, while at the same time earning him a reputation as being someone who "speaks his mind". To commemorate the 30th anniversary of China’s reform and opening-up to the outside world, our reporter Zhou Limin sat down with Zhou to discuss his thoughts on China’s economic progress, problems, and prospects going forward.展开更多
Under conditions of aluminum(Al) toxicity,which severely inhibits root growth in acidic soils, plants rapidly alter their gene expression to optimize physiological fitness for survival. Abscisic acid(ABA) has been sug...Under conditions of aluminum(Al) toxicity,which severely inhibits root growth in acidic soils, plants rapidly alter their gene expression to optimize physiological fitness for survival. Abscisic acid(ABA) has been suggested as a mediator between Al stress and gene expression, but the underlying mechanisms remain largely unknown. Here,we investigated ABA-mediated Al-stress responses, using integrated physiological and molecular biology approaches.We demonstrate that Al stress caused ABA accumulation in the root apex of rice bean(Vigna umbellata [Thunb.] Ohwi &Ohashi), which positively regulated Al tolerance. However,this was not associated with known Al-tolerance mechanisms. Transcriptomic analysis revealed that nearly one-third of the responsive genes were shared between the Al-stress and ABA treatments. We further identified a transcription factor, ABI5, as being positively involved in Al tolerance. Arabidopsis abi5 mutants displayed increased sensitivity to Al, which was not related to the regulation of AtALMT1 and AtMATE expression. Functional categorization of ABI5-mediated genes revealed the importance of cell wall modification and osmoregulation in Al tolerance, a finding supported by osmotic stress treatment on Al tolerance. Our results suggest that ABA signal transduction pathways provide an additional layer of regulatory control over Al tolerance in plants.展开更多
A series of blue and blue‑green Ir(Ⅲ)complexes has been investigated theoretically to explore their electronic structures,photophysical properties,efficiency roll‑off effect,and thermal activation delayed fluorescenc...A series of blue and blue‑green Ir(Ⅲ)complexes has been investigated theoretically to explore their electronic structures,photophysical properties,efficiency roll‑off effect,and thermal activation delayed fluorescence(TADF)properties.All calculations were performed using density functional theory(DFT)and time‑dependent density functional theory(TDDFT).Calculations for electronic structures,frontier molecular orbital characteristics(which determine the efficiency roll‑off effect of the complexes),and photophysical properties were conducted using the Gaussian 09 software package.The calculation of spin‑orbit coupling matrix elements<T|HSOC|S>,which determine the TADF properties of the complexes,was performed using the ORCA software package.The calculation results show that the auxiliary ligand tetraphenylimidodiphosphinate(tpip),a strong electron‑withdrawing group,can mitigate the efficiency roll‑off effect of the complex.Furthermore,TADF is observed in one of the designed complexes,(F_(3)Phppy)_(2)Ir(tpip),where F_(3)Phppy=2‑[4‑(2,4,6‑trifluorophenyl)phenyl]pyridine.展开更多
Turbine blades,due to their intricate geometry,are exposed to multiaxial stresses during operation.Consequently,it is imperative to examine the anisotropy of their stress-rupture behavior across various testing scenar...Turbine blades,due to their intricate geometry,are exposed to multiaxial stresses during operation.Consequently,it is imperative to examine the anisotropy of their stress-rupture behavior across various testing scenarios,particularly under high-temperature conditions.Stress-rupture behavior of a Ni-based single crystal superalloy was investigated under a load varying from 100 MPa to 137 MPa at 1,100℃ for both[001]-and[111]-orientated specimens.Results demonstrate that the rupture behavior of[111]-orientated specimens exhibits obviously higher sensitive to applied stress compared to[001]-orientated specimens.This difference is primarily attributed to the orientation dependentγ'coarsening behavior and distinct dislocation interactions atγ/γ'interfaces.In[001]-oriented specimens,plate-likeγ/γ'rafts rapidly form alongside well-developed interfacial dislocation networks,where theγ/γ'misfit stress dominates the microstructural evolution.In contrast,the[111]-orientated specimens exhibit retained,coarsenedγ'precipitates embedded within theγmatrix,accompanied by poorly developed interfacial dislocation networks.展开更多
Background:This study aims to investigate the underlying mechanisms between parental marital conflict and adolescent short video dependence by constructing a chain mediation model,focusing on the mediating roles of ex...Background:This study aims to investigate the underlying mechanisms between parental marital conflict and adolescent short video dependence by constructing a chain mediation model,focusing on the mediating roles of experiential avoidance and emotional disturbance(anxiety,depression,and stress).Methods:Conducted in January 2025,the research recruited 4125 adolescents from multiple Chinese provinces through convenience sampling;after data cleaning,3957 valid participants(1959 males,1998 females)were included.Using a cross-sectional design,measures included parental marital conflict,experiential avoidance,anxiety,depression,stress,and short video dependence.Results:Pearson correlation analysis revealed significant positive correlations among all variables.Mediation analysis using the SPSS PROCESS macro showed that parental marital conflict directly predicted short video dependence(β=0.269,p<0.001),and also significantly predicted experiential avoidance(β=0.519,p<0.001),anxiety(β=0.072,p<0.001),depression(β=0.067,p<0.001),and stress(β=0.048,p<0.05).Experiential avoidance further predicted anxiety(β=0.521,p<0.001),depression(β=0.489,p<0.001),stress(β=0.408,p<0.001),and short video dependence(β=0.244,p<0.001).While both anxiety(β=0.050,p<0.05)and depression(β=0.116,p<0.001)positively predicted short video dependence,stress did not(β=0.019,p=0.257).Overall,experiential avoidance,anxiety,depression,and stress significantly mediated the relationship between parental marital conflict and short video dependence.Conclusion:These findings confirm that parental marital conflict not only directly influences adolescent short video dependence but also operates through a chain mediation pathway involving experiential avoidance and emotional disturbance,highlighting central psychological mechanisms and providing theoretical support for integrated mental health and behavioral interventions.展开更多
Conglomerate rock's complex and heterogeneous microstructure significantly affects its mechanical properties,especially under dynamic loading.However,research on their dynamic behavior and fracture mechanisms is l...Conglomerate rock's complex and heterogeneous microstructure significantly affects its mechanical properties,especially under dynamic loading.However,research on their dynamic behavior and fracture mechanisms is limited.Through uniaxial compression tests and split Hopkinson pressure bar(SHPB)impact tests,the dynamic compressive mechanical properties and fracture mechanisms of conglomerate rock were studied.Nanoindentation and high-resolution X-ray computed tomography were employed to analyze the micro-mechanical behavior and internal structure of the conglomerate rock.Results indicate significant differences in mechanical properties between different gravel particles and cementing materials,with initial fractures primarily distributed at the gravel-cement interfaces.The dynamic mechanical properties of conglomerate rocks exhibit a clear strain rate dependency.Based on the stress−strain curves and failure characteristics,the dynamic compressive mechanical behavior can be categorized into two types using a critical strain rate.The dynamic compressive strength,peak strain,and toughness of conglomerate rock increased with the strain rate,with the strength at 54 s−1 being 2.6 times that at 6 s−1.The dynamic compressive fracture mechanism of conglomerate rock is related to the strain rate and microstructure;at low strain rates,gravel distribution is the key factor,whereas at high strain rates,gravel content becomes critical.展开更多
Grouting with water–cement mixtures is the most widely used and cost-effective method for managing excess water inflow during tunnel construction.Due to uncertain geological and hydrological conditions,current grouti...Grouting with water–cement mixtures is the most widely used and cost-effective method for managing excess water inflow during tunnel construction.Due to uncertain geological and hydrological conditions,current grouting design relies heavily on the experience of onsite engineers.Recent advances in machine learning offer a promising alternative to traditional design to predict grout volume and improve grouting efficiency.Here,an artificial neural network(ANN)model was developed using the data set from an operation tunnel of Jurong Rock Caverns in Singapore to showcase an efficient and physics-guided training strategy.The ANN model was refined by incorporating the spatial scenarios,including the number of grouting holes in four quadrants of tunneling faces,the sequence of grouting screens along the tunnel axis,and the order of grouting rounds on the tunneling faces.The results indicate that an improved training strategy should encompass the grouting process,from Round 1 with grouting holes uniformly distributed around the tunnel periphery,to Round 2 with grouting holes drilled midway between neighboring first-round holes,and to Round 3 with grouting holes determined by onsite engineers.This model,trained based on the order of grouting rounds,performs better than the other models,highlighting the importance of establishing machine learning models grounded in physical principles.The finding was verified by the data set from another operation tunnel and concluded with a perspective on future grouting research.展开更多
Adolescents who abuse tobacco are more vulnerable to long-term nicotine dependence,and more than 75%of current smokers started smoking during puberty[1].This early initiation is particularly concerning because the pre...Adolescents who abuse tobacco are more vulnerable to long-term nicotine dependence,and more than 75%of current smokers started smoking during puberty[1].This early initiation is particularly concerning because the prefrontal cortex,which governs executive functions and complex behavior,is not fully mature until age 25,making it especially susceptible to the neurotoxic effects of smoking[2].The smoking rate among Chinese secondary school students decreased from 5.9%in 2019 to 4.2%in 2023[3].However,easy access to cigarettes remains a critical obstacle to further reducing the smoking rate[4].China’s tobacco control strategy goes beyond general population measures to include specific policies protecting minors,such as the Tobacco Monopoly Law(1991)and the Law on the Protection of Minors(2006),which explicitly prohibit tobacco sales to minors.A 2020 revision of the Law on the Protection of Minors,which came into effect in June 2021,introduced specific penalties for noncompliance and significantly enhanced the enforceability of the legislation[5].展开更多
Dear Editor,The Cay2.1 channel,also known as the P/Q-type Ca^(2+) channel,is a particular type of voltage-gated Ca^(2+) channel primarily expressed on the presynaptic membrane in the brain[1].It serves as an essential...Dear Editor,The Cay2.1 channel,also known as the P/Q-type Ca^(2+) channel,is a particular type of voltage-gated Ca^(2+) channel primarily expressed on the presynaptic membrane in the brain[1].It serves as an essential part of the precisely orchestrated neurotransmitter release machinery.展开更多
Objective:The aging population is growing rapidly,leading to a rise in chronic diseases and placing significant physical,emotional,and financial strain on caregivers.Managing chronic conditions alongside caregiving re...Objective:The aging population is growing rapidly,leading to a rise in chronic diseases and placing significant physical,emotional,and financial strain on caregivers.Managing chronic conditions alongside caregiving responsibilities often results in burnout,adding to the burden on caregivers.This issue also affects society and healthcare systems through increased costs and greater demands for support services.Understanding the factors contributing to caregiver burden is crucial for creating effective interventions to address these challenges.The aim of this study is to describe the extent of caregiver burden and identify some factors related to burden among caregivers of chronically ill elderly people.By gaining insight into these relationships,this study seeks to identify strategies to reduce the burden on caregivers.Methods:This study utilized a cross-sectional design to examine caregivers of the elderly with chronic diseases receiving treatment in the public healthcare facility.Data collection involved administering structured questionnaires that gathered information on the demographic characteristics of both the elderly and their caregivers,the level of social support received,the functional status of patients as measured by daily activity indices,and the level of caregiver burden.Description was used to elaborate the characteristics of participants.Mann-Whitney,Kruskal-Wallis,and Spearman's correlation test were applied to explore the relationship between variables.Statistical significance was determined at P value<0.05.Results:Caregivers of the elderly with chronic diseases had a moderate care burden score(22.62±11.24,CI:95%).The patients'level of dependence,relationship with the patients,and time spent as a caregiver were factors related to caregiver burden(P<0.05).Conclusions:Those who care for elderly people with chronic diseases suffered great burden.The finding had found a number of factors that influence the caregivers'weight loss.Healthcare providers should consider these relevant factors when developing intervention plans to reduce caregiver burden.展开更多
Computing Power Network(CPN)is a new paradigm that integrates communication,computing,and storage resources to provide services for tasks.However,tasks composed of non-independent subtasks have a preference for the re...Computing Power Network(CPN)is a new paradigm that integrates communication,computing,and storage resources to provide services for tasks.However,tasks composed of non-independent subtasks have a preference for the resources required at each stage,which increases the difficulty of heterogeneous resource allocation and reduces the latency performance of CPN services.Motivated by this,this paper jointly optimizes the full-service cycle of tasks,including transmission,task partitioning,and offloading.First,the transmission bandwidth is dynamically configured based on delay sensitivity of tasks.Second,with the real-time information from edge resource clusters and state resource clusters in the network,the optimal partitioning for a computation task is derived.Third,personalized resource allocation schemes are customized for computation and storage tasks respectively.Finally,the impact of resource parameter configuration on the latency violation probability of CPN is revealed.Moreover,compared with the benchmark schemes,our proposed scheme reduces the network latency violation probability by up to 1.17×in the same network setting.展开更多
Directional three-dimensional carbon-based foams are emerging as highly attractive candidates for promising electromagnetic wave absorbing materials(EWAMs)thanks to their unique architecture,but their construction usu...Directional three-dimensional carbon-based foams are emerging as highly attractive candidates for promising electromagnetic wave absorbing materials(EWAMs)thanks to their unique architecture,but their construction usually involves complex procedures and extremely depends on unidirectional freezing technique.Herein,we propose a groundbreaking approach that leverages the assemblies of salting-out protein induced by ammonium metatungstate(AM)as the precursor,and then acquire directional three-dimensional carbon-based foams through simple pyrolysis.The electrostatic interaction between AM and protein ensures well dispersion of WC_(1−x)nanoparticles on carbon frameworks.The content of WC_(1−x)nanoparticles can be rationally regulated by AM dosage,and it also affects the electromagnetic(EM)properties of final carbon-based foams.The optimized foam exhibits exceptional EM absorption performance,achieving a remarkable minimum reflection loss of−72.0 dB and an effective absorption bandwidth of 6.3 GHz when EM wave propagates parallel to the directional pores.Such performance benefits from the synergistic effects of macroporous architecture and compositional design.Although there is a directional dependence of EM absorption,radar stealth simulation demonstrates that these foams can still promise considerable reduction in radar cross section with the change of incident angle.Moreover,COMSOL simulation further identifies their good performance in preventing EM interference among different electronic components.展开更多
Distributions of nuclear magnetic resonance(NMR)relaxation times provide detailed information about the water in wood.This study documents the water dynamics analysis of T_(2)and T_(1)distributions for saturated delig...Distributions of nuclear magnetic resonance(NMR)relaxation times provide detailed information about the water in wood.This study documents the water dynamics analysis of T_(2)and T_(1)distributions for saturated delignified sapwood(DSW),delignified heartwood(DHW)and lignocellulose(LC)samples at different temperatures.Results indicate that below the freezing point of bulk water,free water freezes,causing its signal to disappear from the distribution.Then,the low temperature distributions of the unfrozen bound water contain more information about its components,with DSW,DHW and LC containing two distinct states of bound water(OH bound water(B-water)and more freely bound water(C-water)).Furthermore,it was observed that within the temperature range of−3°C to−60°C,B-water in DSW,DHW and LC maintained a higher unfrozen water content(UWC)value than C-water,and the T_(1)/T_(2)ratios for B-water were consistently higher than that for C-water,indicating that B-water has a greater antifreeze capacity.T_(2)and T_(1)distributions offer different kinds of information about water components,and all peaks within the distribution have been assigned.展开更多
The mammalian cerebral cortex,despite its variation in brain shape and size,is a stereotypical six-layered structure composed of pyramidal cells,interneurons,astrocytes,microglia,oligodendrocytes,and endothelial cells...The mammalian cerebral cortex,despite its variation in brain shape and size,is a stereotypical six-layered structure composed of pyramidal cells,interneurons,astrocytes,microglia,oligodendrocytes,and endothelial cells.During development,these cells differ in their origin,birth timing,and developmental trajectories.Nonetheless,they converge during development,forming nascent cortical circuits crucial for organismal behavior.While the relative proportions of cortical cells vary between regions.展开更多
The coexistence of emerging containments,such as antibiotic resistant bacteria(ARB),antibiotic-resistant genes(ARGs)and antibiotics,potentially influence elimination efficiencies in UV light-emitting diode(UV-LED)alon...The coexistence of emerging containments,such as antibiotic resistant bacteria(ARB),antibiotic-resistant genes(ARGs)and antibiotics,potentially influence elimination efficiencies in UV light-emitting diode(UV-LED)alone and UV-LED/H_(2)O_(2) system as their complex interactions.Tetracycline(TC)degradation efficiency(kF)correlated closely with its UV molar absorbance(R^(2)=0.831)in UV-LED alone system and with·OH yield(R^(2)=0.999)in UV-LED/H_(2)O_(2) system across studied wavelengths(265,280 and 310 nm).The kF values for intracellular DNA(i-ARGs)also exhibited a high correlation with UV-LED wavelengths in both systems(R^(2)=0.997-0.999).The coexistence of TC and ARB/ARGs resulted in a mutual inhibition of their degradation efficiencies due to competition for photons and·OH,along with the consequent reduction in intracellular ROS within ARB,with their degradation efficiencies exhibiting marked dependence on wavelength in both systems.Notably,the UV-LED/H_(2)O_(2) system at 265 nm effectively achieved the simultaneous removal of TC,ARB and ARGs with minimal energy consumption,and successfully fragmented ARGs.The degradation pathway of TC was analyzed,and the biotoxicity of its degradation intermediates demonstrated the environmental friendliness and safety of UV-LED/H_(2)O_(2) technology.This study elucidated the competitive interactions between antibiotics and ARB/ARGs within UV-LED/H_(2)O_(2) system,providing a promising approach for their simultaneous removal while ensuring energy efficiency.展开更多
Dear Editor,In this letter,we focus on the algebraic relationship between the coefficient matrices and the solution of the stochastic algebraic Riccati equation.It is revealed that,if the coefficient matrices are in a...Dear Editor,In this letter,we focus on the algebraic relationship between the coefficient matrices and the solution of the stochastic algebraic Riccati equation.It is revealed that,if the coefficient matrices are in an algebra,then the solution(and also the control gain in many cases)is also in the same algebra.The main result is verified by a numerical simulation.展开更多
Among the charged leptons,theτelectric dipole moment dτis the least constrained.We show that the Im[d_(τ)]imposes strong constraints on new physics that have yet to be discussed.Motivated in particular by the Super...Among the charged leptons,theτelectric dipole moment dτis the least constrained.We show that the Im[d_(τ)]imposes strong constraints on new physics that have yet to be discussed.Motivated in particular by the Super Tau-Charm Facility(STCF),which will provide a uniquely clean environment for precisionτ-physics,we study the momentum-transfer dependence of d_(τ)(q^(2))and compare the projected sensitivities of STCF and BelleⅡ.Our analysis shows that an axion-like coupling of the τ lepton can induce sizable real and imaginary components of the EDM.The predicted EDM values may approach the present experimental sensitivities,making them accessible to future measurements at Belle II and the STCF.展开更多
基金supported by the funds from Huazhong University of Science and Technology and US NIH grant GM 072744
文摘All living cells in a human body are made of the same DNA molecule but cells in different tissues express different genes and proteins.How the transcription process is controlled and regulated is largely unknown.Specifically,mechanical forces are increasingly recognized to play critical roles in cell and tissue functions.However,what controls force-induced gene transcription is elusive.Recently we have reported that a local surface force transfers from integrins to the cytoskeleton and the link of nucleoskeleton and the cytoskeleton(LINC)into the nucleus and deforms chromatin directly to induce rapid activation of transgene DHFR.Here we show that endogenous mechanoresponsive genes egr-1 and Cav1 are rapidly upregulated and their upregulation depends on stress angles relative to the cell long axis,suggesting direct impact of these genes by force.Demethylation of histone 3 at lysine 9(H3K9)trimethylation(H3K9me3)at nuclear interiors(euchromatin)is necessary for force-induced transcription upregulation.Our findings suggest that force-rapid upregulation of mechanoresponsive genes by force depends on H3K9me3 demethylation.
基金supported by NIH Grant R01GM072562 and NSF Grant IOS1557904
文摘The success of the fruit fly Drosophila melanogaster as a model organism is heavily attributed to the expansive range and multitude of genetic and molecular tools available to modify gene expression at will. The GaI4/UAS binary system is one of the most important and widely used genetic tools in Drosophila designed for targeted gene expression （Brand and Perrimon, 1993）, which allows ectopic expression of any gene （or transgene） in specific tissues, independent of their native regulators. However, a drawback of the original UASt-transgene is its silence in germline cells--when the UASt-RFPhis transgene was driven by a ubiquitously expressed 6al4 under the ActinSC promoter （act-Gal4）, RFP expression was only detected in the somatic follicle cells, but not in the germline nurse cells or the oocyte （Fig. 1A）.
文摘Mao Yushi is a well known economist, academic, and speaker on Chinese macro-economic issues. His ideas on entrepreneurship, morality, and the law in China’s economic system has garnered him national recognition, while at the same time earning him a reputation as being someone who "speaks his mind". To commemorate the 30th anniversary of China’s reform and opening-up to the outside world, our reporter Zhou Limin sat down with Zhou to discuss his thoughts on China’s economic progress, problems, and prospects going forward.
基金supported by the National Natural Science Foundation of China (31501827, 31222049, 31071849, and 31572193)National Basic Research Program of China (973 Program, 2014CB441002)+1 种基金the Open Foundation for State Key Laboratory of Plant Physiology and Biochemistrythe Innovation Team for Farmland Non-pollution Production of Yunnan Province (2017HC015)
文摘Under conditions of aluminum(Al) toxicity,which severely inhibits root growth in acidic soils, plants rapidly alter their gene expression to optimize physiological fitness for survival. Abscisic acid(ABA) has been suggested as a mediator between Al stress and gene expression, but the underlying mechanisms remain largely unknown. Here,we investigated ABA-mediated Al-stress responses, using integrated physiological and molecular biology approaches.We demonstrate that Al stress caused ABA accumulation in the root apex of rice bean(Vigna umbellata [Thunb.] Ohwi &Ohashi), which positively regulated Al tolerance. However,this was not associated with known Al-tolerance mechanisms. Transcriptomic analysis revealed that nearly one-third of the responsive genes were shared between the Al-stress and ABA treatments. We further identified a transcription factor, ABI5, as being positively involved in Al tolerance. Arabidopsis abi5 mutants displayed increased sensitivity to Al, which was not related to the regulation of AtALMT1 and AtMATE expression. Functional categorization of ABI5-mediated genes revealed the importance of cell wall modification and osmoregulation in Al tolerance, a finding supported by osmotic stress treatment on Al tolerance. Our results suggest that ABA signal transduction pathways provide an additional layer of regulatory control over Al tolerance in plants.
文摘A series of blue and blue‑green Ir(Ⅲ)complexes has been investigated theoretically to explore their electronic structures,photophysical properties,efficiency roll‑off effect,and thermal activation delayed fluorescence(TADF)properties.All calculations were performed using density functional theory(DFT)and time‑dependent density functional theory(TDDFT).Calculations for electronic structures,frontier molecular orbital characteristics(which determine the efficiency roll‑off effect of the complexes),and photophysical properties were conducted using the Gaussian 09 software package.The calculation of spin‑orbit coupling matrix elements<T|HSOC|S>,which determine the TADF properties of the complexes,was performed using the ORCA software package.The calculation results show that the auxiliary ligand tetraphenylimidodiphosphinate(tpip),a strong electron‑withdrawing group,can mitigate the efficiency roll‑off effect of the complex.Furthermore,TADF is observed in one of the designed complexes,(F_(3)Phppy)_(2)Ir(tpip),where F_(3)Phppy=2‑[4‑(2,4,6‑trifluorophenyl)phenyl]pyridine.
基金financially supported by the National Science and Technology Major Project of China(No.2019-VII-0019-0161 and No.2019-VII-0004-0144)the National Natural Science Foundation of China(No.92360302)the Shandong Provincial Natural Science Foundation of China(No.ZR2021QE103)。
文摘Turbine blades,due to their intricate geometry,are exposed to multiaxial stresses during operation.Consequently,it is imperative to examine the anisotropy of their stress-rupture behavior across various testing scenarios,particularly under high-temperature conditions.Stress-rupture behavior of a Ni-based single crystal superalloy was investigated under a load varying from 100 MPa to 137 MPa at 1,100℃ for both[001]-and[111]-orientated specimens.Results demonstrate that the rupture behavior of[111]-orientated specimens exhibits obviously higher sensitive to applied stress compared to[001]-orientated specimens.This difference is primarily attributed to the orientation dependentγ'coarsening behavior and distinct dislocation interactions atγ/γ'interfaces.In[001]-oriented specimens,plate-likeγ/γ'rafts rapidly form alongside well-developed interfacial dislocation networks,where theγ/γ'misfit stress dominates the microstructural evolution.In contrast,the[111]-orientated specimens exhibit retained,coarsenedγ'precipitates embedded within theγmatrix,accompanied by poorly developed interfacial dislocation networks.
文摘Background:This study aims to investigate the underlying mechanisms between parental marital conflict and adolescent short video dependence by constructing a chain mediation model,focusing on the mediating roles of experiential avoidance and emotional disturbance(anxiety,depression,and stress).Methods:Conducted in January 2025,the research recruited 4125 adolescents from multiple Chinese provinces through convenience sampling;after data cleaning,3957 valid participants(1959 males,1998 females)were included.Using a cross-sectional design,measures included parental marital conflict,experiential avoidance,anxiety,depression,stress,and short video dependence.Results:Pearson correlation analysis revealed significant positive correlations among all variables.Mediation analysis using the SPSS PROCESS macro showed that parental marital conflict directly predicted short video dependence(β=0.269,p<0.001),and also significantly predicted experiential avoidance(β=0.519,p<0.001),anxiety(β=0.072,p<0.001),depression(β=0.067,p<0.001),and stress(β=0.048,p<0.05).Experiential avoidance further predicted anxiety(β=0.521,p<0.001),depression(β=0.489,p<0.001),stress(β=0.408,p<0.001),and short video dependence(β=0.244,p<0.001).While both anxiety(β=0.050,p<0.05)and depression(β=0.116,p<0.001)positively predicted short video dependence,stress did not(β=0.019,p=0.257).Overall,experiential avoidance,anxiety,depression,and stress significantly mediated the relationship between parental marital conflict and short video dependence.Conclusion:These findings confirm that parental marital conflict not only directly influences adolescent short video dependence but also operates through a chain mediation pathway involving experiential avoidance and emotional disturbance,highlighting central psychological mechanisms and providing theoretical support for integrated mental health and behavioral interventions.
基金Project(51978674)supported by the National Natural Science Foundation of China。
文摘Conglomerate rock's complex and heterogeneous microstructure significantly affects its mechanical properties,especially under dynamic loading.However,research on their dynamic behavior and fracture mechanisms is limited.Through uniaxial compression tests and split Hopkinson pressure bar(SHPB)impact tests,the dynamic compressive mechanical properties and fracture mechanisms of conglomerate rock were studied.Nanoindentation and high-resolution X-ray computed tomography were employed to analyze the micro-mechanical behavior and internal structure of the conglomerate rock.Results indicate significant differences in mechanical properties between different gravel particles and cementing materials,with initial fractures primarily distributed at the gravel-cement interfaces.The dynamic mechanical properties of conglomerate rocks exhibit a clear strain rate dependency.Based on the stress−strain curves and failure characteristics,the dynamic compressive mechanical behavior can be categorized into two types using a critical strain rate.The dynamic compressive strength,peak strain,and toughness of conglomerate rock increased with the strain rate,with the strength at 54 s−1 being 2.6 times that at 6 s−1.The dynamic compressive fracture mechanism of conglomerate rock is related to the strain rate and microstructure;at low strain rates,gravel distribution is the key factor,whereas at high strain rates,gravel content becomes critical.
基金Ministry of Education-Singapore,Grant/Award Number:RG143/23。
文摘Grouting with water–cement mixtures is the most widely used and cost-effective method for managing excess water inflow during tunnel construction.Due to uncertain geological and hydrological conditions,current grouting design relies heavily on the experience of onsite engineers.Recent advances in machine learning offer a promising alternative to traditional design to predict grout volume and improve grouting efficiency.Here,an artificial neural network(ANN)model was developed using the data set from an operation tunnel of Jurong Rock Caverns in Singapore to showcase an efficient and physics-guided training strategy.The ANN model was refined by incorporating the spatial scenarios,including the number of grouting holes in four quadrants of tunneling faces,the sequence of grouting screens along the tunnel axis,and the order of grouting rounds on the tunneling faces.The results indicate that an improved training strategy should encompass the grouting process,from Round 1 with grouting holes uniformly distributed around the tunnel periphery,to Round 2 with grouting holes drilled midway between neighboring first-round holes,and to Round 3 with grouting holes determined by onsite engineers.This model,trained based on the order of grouting rounds,performs better than the other models,highlighting the importance of establishing machine learning models grounded in physical principles.The finding was verified by the data set from another operation tunnel and concluded with a perspective on future grouting research.
文摘Adolescents who abuse tobacco are more vulnerable to long-term nicotine dependence,and more than 75%of current smokers started smoking during puberty[1].This early initiation is particularly concerning because the prefrontal cortex,which governs executive functions and complex behavior,is not fully mature until age 25,making it especially susceptible to the neurotoxic effects of smoking[2].The smoking rate among Chinese secondary school students decreased from 5.9%in 2019 to 4.2%in 2023[3].However,easy access to cigarettes remains a critical obstacle to further reducing the smoking rate[4].China’s tobacco control strategy goes beyond general population measures to include specific policies protecting minors,such as the Tobacco Monopoly Law(1991)and the Law on the Protection of Minors(2006),which explicitly prohibit tobacco sales to minors.A 2020 revision of the Law on the Protection of Minors,which came into effect in June 2021,introduced specific penalties for noncompliance and significantly enhanced the enforceability of the legislation[5].
基金supported by the National Natural Science Foundation of China(32100773 and U20A6005)the National Science and Technology Innovation 2030-Major Project of China(2021ZD0202500)+4 种基金Shenzhen Medical Research Fund(B2402024)China Postdoctoral Science Foundation(2021M693296)Shenzhen Science and Technology Program(JCYJ20230807093815032)Guangdong High-level Hospital Construction Fund(ynkt2021-zz33 and LCYJ2022093)the Natural Science Foundation of Guangdong Province,China(2022A1515010297).
文摘Dear Editor,The Cay2.1 channel,also known as the P/Q-type Ca^(2+) channel,is a particular type of voltage-gated Ca^(2+) channel primarily expressed on the presynaptic membrane in the brain[1].It serves as an essential part of the precisely orchestrated neurotransmitter release machinery.
基金Da Nang University of Medical Technology and PharmacyDa Nang C Hospital for the invaluable support they provided in facilitating this research。
文摘Objective:The aging population is growing rapidly,leading to a rise in chronic diseases and placing significant physical,emotional,and financial strain on caregivers.Managing chronic conditions alongside caregiving responsibilities often results in burnout,adding to the burden on caregivers.This issue also affects society and healthcare systems through increased costs and greater demands for support services.Understanding the factors contributing to caregiver burden is crucial for creating effective interventions to address these challenges.The aim of this study is to describe the extent of caregiver burden and identify some factors related to burden among caregivers of chronically ill elderly people.By gaining insight into these relationships,this study seeks to identify strategies to reduce the burden on caregivers.Methods:This study utilized a cross-sectional design to examine caregivers of the elderly with chronic diseases receiving treatment in the public healthcare facility.Data collection involved administering structured questionnaires that gathered information on the demographic characteristics of both the elderly and their caregivers,the level of social support received,the functional status of patients as measured by daily activity indices,and the level of caregiver burden.Description was used to elaborate the characteristics of participants.Mann-Whitney,Kruskal-Wallis,and Spearman's correlation test were applied to explore the relationship between variables.Statistical significance was determined at P value<0.05.Results:Caregivers of the elderly with chronic diseases had a moderate care burden score(22.62±11.24,CI:95%).The patients'level of dependence,relationship with the patients,and time spent as a caregiver were factors related to caregiver burden(P<0.05).Conclusions:Those who care for elderly people with chronic diseases suffered great burden.The finding had found a number of factors that influence the caregivers'weight loss.Healthcare providers should consider these relevant factors when developing intervention plans to reduce caregiver burden.
基金supported in part by the Chongqing Postgraduate Research and Innovation Project(CYB22250)National Natural Science Foundation of China(62271096,U20A20157)+2 种基金Natural Science Foundation of Chongqing-China(CSTB2023NSCQ-LZX0134,CSTB2024NSCQ-LZX0124)University Innovation Research Group of Chongqing(CXQT20017)Youth Innovation Group Support Program of ICE Discipline of CQUPT(SCIE-QN-2022-04)。
文摘Computing Power Network(CPN)is a new paradigm that integrates communication,computing,and storage resources to provide services for tasks.However,tasks composed of non-independent subtasks have a preference for the resources required at each stage,which increases the difficulty of heterogeneous resource allocation and reduces the latency performance of CPN services.Motivated by this,this paper jointly optimizes the full-service cycle of tasks,including transmission,task partitioning,and offloading.First,the transmission bandwidth is dynamically configured based on delay sensitivity of tasks.Second,with the real-time information from edge resource clusters and state resource clusters in the network,the optimal partitioning for a computation task is derived.Third,personalized resource allocation schemes are customized for computation and storage tasks respectively.Finally,the impact of resource parameter configuration on the latency violation probability of CPN is revealed.Moreover,compared with the benchmark schemes,our proposed scheme reduces the network latency violation probability by up to 1.17×in the same network setting.
基金financially supported by the National Natural Science Foundation of China(Nos.22475057 and No.52373262).
文摘Directional three-dimensional carbon-based foams are emerging as highly attractive candidates for promising electromagnetic wave absorbing materials(EWAMs)thanks to their unique architecture,but their construction usually involves complex procedures and extremely depends on unidirectional freezing technique.Herein,we propose a groundbreaking approach that leverages the assemblies of salting-out protein induced by ammonium metatungstate(AM)as the precursor,and then acquire directional three-dimensional carbon-based foams through simple pyrolysis.The electrostatic interaction between AM and protein ensures well dispersion of WC_(1−x)nanoparticles on carbon frameworks.The content of WC_(1−x)nanoparticles can be rationally regulated by AM dosage,and it also affects the electromagnetic(EM)properties of final carbon-based foams.The optimized foam exhibits exceptional EM absorption performance,achieving a remarkable minimum reflection loss of−72.0 dB and an effective absorption bandwidth of 6.3 GHz when EM wave propagates parallel to the directional pores.Such performance benefits from the synergistic effects of macroporous architecture and compositional design.Although there is a directional dependence of EM absorption,radar stealth simulation demonstrates that these foams can still promise considerable reduction in radar cross section with the change of incident angle.Moreover,COMSOL simulation further identifies their good performance in preventing EM interference among different electronic components.
基金supported by Natural Science Foundation of Inner Mongolia Autonomous Region of China (2023MS03027)the National Natural Science Foundation of China (31860185 and 31160141)
文摘Distributions of nuclear magnetic resonance(NMR)relaxation times provide detailed information about the water in wood.This study documents the water dynamics analysis of T_(2)and T_(1)distributions for saturated delignified sapwood(DSW),delignified heartwood(DHW)and lignocellulose(LC)samples at different temperatures.Results indicate that below the freezing point of bulk water,free water freezes,causing its signal to disappear from the distribution.Then,the low temperature distributions of the unfrozen bound water contain more information about its components,with DSW,DHW and LC containing two distinct states of bound water(OH bound water(B-water)and more freely bound water(C-water)).Furthermore,it was observed that within the temperature range of−3°C to−60°C,B-water in DSW,DHW and LC maintained a higher unfrozen water content(UWC)value than C-water,and the T_(1)/T_(2)ratios for B-water were consistently higher than that for C-water,indicating that B-water has a greater antifreeze capacity.T_(2)and T_(1)distributions offer different kinds of information about water components,and all peaks within the distribution have been assigned.
基金supported by the Medical Research Council(MR/T030143/1)grant and the University of Manchester。
文摘The mammalian cerebral cortex,despite its variation in brain shape and size,is a stereotypical six-layered structure composed of pyramidal cells,interneurons,astrocytes,microglia,oligodendrocytes,and endothelial cells.During development,these cells differ in their origin,birth timing,and developmental trajectories.Nonetheless,they converge during development,forming nascent cortical circuits crucial for organismal behavior.While the relative proportions of cortical cells vary between regions.
基金supported by Major Scientific and Technological Innovation Project of Shandong Province(No.2020CXGC011204)Qingdao Natural Science Foundation(No.23-2-1-234-zyyd-jch).
文摘The coexistence of emerging containments,such as antibiotic resistant bacteria(ARB),antibiotic-resistant genes(ARGs)and antibiotics,potentially influence elimination efficiencies in UV light-emitting diode(UV-LED)alone and UV-LED/H_(2)O_(2) system as their complex interactions.Tetracycline(TC)degradation efficiency(kF)correlated closely with its UV molar absorbance(R^(2)=0.831)in UV-LED alone system and with·OH yield(R^(2)=0.999)in UV-LED/H_(2)O_(2) system across studied wavelengths(265,280 and 310 nm).The kF values for intracellular DNA(i-ARGs)also exhibited a high correlation with UV-LED wavelengths in both systems(R^(2)=0.997-0.999).The coexistence of TC and ARB/ARGs resulted in a mutual inhibition of their degradation efficiencies due to competition for photons and·OH,along with the consequent reduction in intracellular ROS within ARB,with their degradation efficiencies exhibiting marked dependence on wavelength in both systems.Notably,the UV-LED/H_(2)O_(2) system at 265 nm effectively achieved the simultaneous removal of TC,ARB and ARGs with minimal energy consumption,and successfully fragmented ARGs.The degradation pathway of TC was analyzed,and the biotoxicity of its degradation intermediates demonstrated the environmental friendliness and safety of UV-LED/H_(2)O_(2) technology.This study elucidated the competitive interactions between antibiotics and ARB/ARGs within UV-LED/H_(2)O_(2) system,providing a promising approach for their simultaneous removal while ensuring energy efficiency.
文摘Dear Editor,In this letter,we focus on the algebraic relationship between the coefficient matrices and the solution of the stochastic algebraic Riccati equation.It is revealed that,if the coefficient matrices are in an algebra,then the solution(and also the control gain in many cases)is also in the same algebra.The main result is verified by a numerical simulation.
基金supported by the National Natural Science Foundation of China (Grant Nos.12090064,12205063,12375088,and W2441004)the Fundamental Research Funds for the Central Universitiesin part by the National Key Research and Development Program of China (Grant No.2020YFC2201501)。
文摘Among the charged leptons,theτelectric dipole moment dτis the least constrained.We show that the Im[d_(τ)]imposes strong constraints on new physics that have yet to be discussed.Motivated in particular by the Super Tau-Charm Facility(STCF),which will provide a uniquely clean environment for precisionτ-physics,we study the momentum-transfer dependence of d_(τ)(q^(2))and compare the projected sensitivities of STCF and BelleⅡ.Our analysis shows that an axion-like coupling of the τ lepton can induce sizable real and imaginary components of the EDM.The predicted EDM values may approach the present experimental sensitivities,making them accessible to future measurements at Belle II and the STCF.
