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Determinants of loan repayment among agricultural microcredit finance group members in Delta state, Nigeria 被引量:3
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作者 Solomon Enimu Emmanuel O.Eyo Eucharia A.Ajah 《Financial Innovation》 2017年第1期303-314,共12页
Background:This study examined the determinants of loan repayment among microcredit finance group members in Delta State,Nigeria.Methods:To capture the determinants of loan repayment in the study area,a total of 48 mi... Background:This study examined the determinants of loan repayment among microcredit finance group members in Delta State,Nigeria.Methods:To capture the determinants of loan repayment in the study area,a total of 48 microcredit groups and 300 microcredit group members were randomly selected through a multi-stage random sampling technique.The study data was collected by questionnaire.Statistical tools such as simple descriptive statistics(table,frequency,percentage and mean)and a multiple regression analysis were used to examine the data.Results:The results indicate that females form a greater proportion of the study area microcredit group members at 70%,moreover 73%of the respondents have a household size of between 6 to 10 persons.These findings revealed that the groups had a mean 8 years of existence with a mean membership size of 13 persons.Further,an average interest rate of 40 percent per annum was charged on loans,with mean loan duration of 6 months.The regression’s result demonstrated that the determinants of the group member’s loan repayment included the group member’s age,household size,house income,and educational level,the amount of credit received,length of stay in their locality,distance to the credit source,supervision and disbursement lag.Conclusion:Therefore it was suggested that the various agricultural microcredit finance groups should carefully examine the significant determinants of loan repayment for the approach’s viability and sustainability and for optimum repayment performance. 展开更多
关键词 Determinants Loan repayment MICROCREDIT Groups Members delta state
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Chemical Compostion of Earthen Pond Feed from Spring Water, in Asaba Campus, Asaba, Delta State, Nigeria
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作者 Olele Nkeonyeasua Florence Nwabueze Arimiche Agatha Ekelemu Jerimoth Kesiana 《Journal of Agricultural Science and Technology(B)》 2013年第1期56-61,共6页
Sound pond productivity accompanied with adequate fish health is maintained, when water quality parameters are conducive. The study evaluated the chemical composition of a pond feed from spring water, in Asaba Campus.... Sound pond productivity accompanied with adequate fish health is maintained, when water quality parameters are conducive. The study evaluated the chemical composition of a pond feed from spring water, in Asaba Campus. Sampling was carried out from September 2011 to February 2012 on a monthly basis. Surface water samples were collected between the hours of 7:00-9:00 am from the pond on each sampling day. Hydrogen-ion-concentration was in the range of 6.5 to 8.0 units. Dissolved oxygen was the highest in February 2012 with a value of 11.0 mg/L while it was the lowest in December 2011 with a value of 9.0 mg/L. Biological oxygen demand ranged from 3.5 to 5.0 mg/L. The chemical oxygen demand was the highest in December (10.00 mg/L) and lowest between January and February (8.0mg/L). The highest alkalinity was observed in October with a value of 1.05 mg/L and lowest in December with a value of 0.042 mg/L. Conductivity values ranged from 0.075 to 0.12 μS/cm. Total phosphorus was the highest in October with a value of 1.01 mg/L and lowest in December with a value of 0.83 mg/L. Total dissolved solids ranged from 90 to 105 mg/L. Values of physco-chemical parameters revealed that the pond was not polluted. Water quality analysis of the aquatics is of economic advantage to the fish farmer, hence, the need for its assessment at regular intervals. This is a quality assurance process that assures early dictation of toxic substances and mitigation processes to adopt before problems arise. In this way, the good health of organisms in the aquatic ecosystem and those of human dependent on them are guaranteed. 展开更多
关键词 Chemical composition pond water spring water Asaba campus Asaba delta state NIGERIA
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Perception of Adolescents on the Attitudes of Providers on Their Access and Use of Reproductive Health Services in Delta State, Nigeria 被引量:1
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作者 Andrew G. Onokerhoraye Johnson Egbemudia Dudu 《Health》 2017年第1期88-105,共18页
This paper examines the perception of adolescents on the attitudes of providers on their access and use of reproductive health services (ARHS) in Delta State, Nigeria, with a view of assessing the impact of providers... This paper examines the perception of adolescents on the attitudes of providers on their access and use of reproductive health services (ARHS) in Delta State, Nigeria, with a view of assessing the impact of providers’ attitude on the use of adolescents’ reproductive health services in Delta State. The study adopted a survey design to collect primary data using questionnaires and focus group discussions (FGDs) from adolescents in a sample of schools. A sample size of 1500 respondents was taken from 12 schools in six Local Government Areas in three Senatorial Districts in Delta State, Nigeria. The locations of the schools were such that six each were in rural and urban communities respectively. The result from the study was that unfriendly attitudes of providers which keep adolescents waiting, inadequate duration of consultations, judgmental attitudes of some providers, lack of satisfactory services provision and lack of confidentiality will put off adolescents from accessing and using adolescents’ reproductive health services irrespective of their sex, age, class, religion, residence, ethnic group, parents’ education or income levels. The paper concludes that medical personnel take all these issues very seriously when dealing with adolescents to enhance access and use adolescents’ reproductive health services in Delta State and indeed Nigeria. 展开更多
关键词 PROVIDERS ATTITUDES Adolescents REPRODUCTIVE Health delta state NIGERIA
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Seroprevalence of <i>Helicobacter pylori</i>Infection and Risk Factors among Asymptomatic Subjects in Delta State, Nigeria
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作者 Kingsley Ifeanyichukwu Omosor Omasan Herrienta Omosor +8 位作者 Isaiah Nnana Ibeh Babatunde Ishola Gabriel Adejumo Usman Itakure Abdulkadir Uchechukwu Dimkpa Gregory Ashimedua Uchuno Ojo Moses Oke Ramatu Lawal Abdulkadir Musa Vaima Hamidu Alaba Michael Emmanuel 《Advances in Microbiology》 2017年第9期641-652,共12页
Aim: The study aimed at evaluating the seroprevalence of H. pylori infection and its associated risk factors in a cross-section of asymptomatic adult population in Niger-Delta, Nigeria. Methodology: 408 apparently hea... Aim: The study aimed at evaluating the seroprevalence of H. pylori infection and its associated risk factors in a cross-section of asymptomatic adult population in Niger-Delta, Nigeria. Methodology: 408 apparently healthy volunteers, aged between 18 - 87 years were recruited for this study. Blood samples were collected from participants and analyzed for H. pylori antibody (IgG) qualitatively with Combo rapid kits and quantitatively with Accu-Bind ELISA Kits. Results: The overall prevalence of Helicobacter pylori colonization in 408 asymptomatic adults was 52.5% (n = 214) and 48.3% (n = 197) by qualitative (Combo rapid kits) and quantitative (Accu-Bind ELISA Kits) serological test methods respectively. H. pylori infection did not differ statistically between genders (p = 0.962) and among age groups (p = 0.185). In addition, multivariate logistic regression indicated that sex and age were not associated with risk of H. pylori. However, participants from Delta Central were at greater risk (OR = 1.89;p = 0.014) of H. pylori infection compared with those from Delta South, but those from Delta North were not at greater risk of infection compared with those from Delta South (p = 0.476). Conclusion: This study indicated an intermediate seroprevalence of H. pylori among asymptomatic adults in Delta state, Nigeria. The prevalence of H. pylori infection was linked to geographical regions but not with sex and age. 展开更多
关键词 Helicobacter pylori INFECTION Risk Factors delta state NIGERIA
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Knowledge, Attitude and Oral Hygiene Practices among Medical Practitioners in Delta State, Nigeria
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作者 Mabel O. Etetafia Ese Anibor +1 位作者 Efe J. Ojigho-Jaiyeoba Martins Obaroefe 《Open Journal of Applied Sciences》 2018年第12期576-585,共10页
Background: The knowledge of good oral hygiene is of paramount importance for the technical knowhow to keep one’s mouth clean and free from periodontal diseases. Thus, one’s attitude towards oral hygiene directly af... Background: The knowledge of good oral hygiene is of paramount importance for the technical knowhow to keep one’s mouth clean and free from periodontal diseases. Thus, one’s attitude towards oral hygiene directly affects the oral health status. Aims: The study aimed at evaluating the knowledge, attitude and oral hygiene practices among medical practitioners in Delta State, Nigeria. The research also aimed at determining the effect of sex on knowledge, attitude and oral hygiene practices. Methodology: This study was an observational cross sectional study. Purposive sampling technique was employed. A total of a hundred and twenty-three health care providers were assessed with a structured questionnaire. Ethical approval was obtained from the Ethics and Research Committee in the Department of Human Anatomy and Cell Biology, Delta State University, Abraka, Nigeria. Data was analyzed using SPSS version 18.0 package. Descriptive statistics was analyzed using simple frequency percentages distribution and association between categorical variables and sex was done using a chi-square test. Significance was accepted at p Result: Findings from the study present 76.0% males and 24.0% females in the studied population. Five categories of health care providers were assessed, 63.0% of respondents were medical officers, 21.0% were consultants, and 10.0% were residents, while 6.0% were house officers. The results showed that 43.9% of the participants brushed their teeth once daily, 54.5% twice daily while 1.6% thrice daily. Respondents were asked the last time they visited a dentist. Out of the 123 participants, 37.4% never visited, 20.3% claimed six months ago, 13.0% visited a year ago, 10.6% two years ago and 19.40% visited more than two years ago. It also shows percentage distribution of variant types of last treatment, 19.5% had extraction, 10.6% had filling, and 33.3% had scaling and polishing while 36.6% had other types of dental treatment. The study revealed that the majority of the respondents (93.5%) had a positive attitude towards oral health. A total of 91.9% of the participants had knowledge of oral hygiene, while 8.1% had no idea of oral hygiene. More than half of the respondent (57.2%) agreed and strongly agreed that oral hygiene knowledge in medical schools was adequate while 35.0% disagreed and strongly disagreed. There was no significant association (p > 0.05) between frequency of daily teeth brushing, last dental visit, variant treatments and sex. Conclusion: Findings from this study showed that the majority of the participants had an adequate knowledge on proper oral hygiene care and they had a positive attitude towards oral health. Being health care providers, the adequate knowledge and positive attitude could have a positive impact on the patients. 展开更多
关键词 KNOWLEDGE ATTITUDES Oral HYGIENE delta state Medical PRACTITIONER
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Delta算子脉冲切换时滞系统的稳定性分析与镇定
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作者 李章蝶 肖民卿 《井冈山大学学报(自然科学版)》 2025年第6期1-9,共9页
针对所有子系统不稳定的Delta算子脉冲切换时滞系统,基于模态依赖的间隔驻留时间切换规则,运用时变Lyapunov-Krasovskii函数法,得到使所有子系统不稳定的Delta算子脉冲切换时滞系统渐近稳定的稳定性判据。同时,对于开环不稳定的系统,设... 针对所有子系统不稳定的Delta算子脉冲切换时滞系统,基于模态依赖的间隔驻留时间切换规则,运用时变Lyapunov-Krasovskii函数法,得到使所有子系统不稳定的Delta算子脉冲切换时滞系统渐近稳定的稳定性判据。同时,对于开环不稳定的系统,设计时变状态反馈控制器,以确保闭环系统的稳定性。最后,通过数值算例验证了时变状态反馈控制器设计方法的有效性。 展开更多
关键词 delta算子切换系统 脉冲 时滞 时变状态反馈控制器 稳定性
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广义Delta算子系统的状态反馈容许控制 被引量:9
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作者 毛青堂 董心壮 田万虎 《青岛大学学报(工程技术版)》 CAS 2013年第1期14-18,共5页
针对广义Delta算子系统,本文利用线性矩阵不等式方法研究状态反馈容许控制问题,给出广义Delta算子系统容许的一个新的充分必要条件,并为不容许的广义Delta算子系统设计了合适的状态反馈控制器,保证所得的闭环系统容许。数值算例表明,本... 针对广义Delta算子系统,本文利用线性矩阵不等式方法研究状态反馈容许控制问题,给出广义Delta算子系统容许的一个新的充分必要条件,并为不容许的广义Delta算子系统设计了合适的状态反馈控制器,保证所得的闭环系统容许。数值算例表明,本文所得结果是有效和可行的。 展开更多
关键词 广义delta算子系统 状态反馈 容许控制 线性矩阵不等式
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Delta算子系统D稳定鲁棒状态观测器的设计方法 被引量:1
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作者 刘满 井元伟 张嗣瀛 《东北大学学报(自然科学版)》 EI CAS CSCD 北大核心 2005年第4期307-310,共4页
研究了Delta算子描述的线性不确定系统基于圆形区域极点配置的状态观测器(定义作D稳定鲁棒状态观测器)的设计问题·利用离散的Delta算子代数Ricatti方程,给出了一类参数不确定Delta算子系统D稳定鲁棒状态观测器存在的一个充要条件... 研究了Delta算子描述的线性不确定系统基于圆形区域极点配置的状态观测器(定义作D稳定鲁棒状态观测器)的设计问题·利用离散的Delta算子代数Ricatti方程,给出了一类参数不确定Delta算子系统D稳定鲁棒状态观测器存在的一个充要条件及其设计方法,这一表述,有利于进行理论推导·为便于计算将这一结果转化成线性矩阵不等式·所设计的D稳定鲁棒状态观测器具有很好的鲁棒性,并将连续与离散系统有关该问题的结果统一到了Delta算子框架中· 展开更多
关键词 delta算子系统 区域极点配置 状态观测器 不确定性 鲁棒性
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基于LMI的Delta域内的H_∞滤波器问题 被引量:1
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作者 杨晨影 李惠光 《广东自动化与信息工程》 2002年第2期4-6,9,共4页
用LMI方法来研究Delta算子描述下的线性定常系统的H_∞滤波器问题,基于一个LMI给出了Delta域内的H_∞观测器型状态估计器,充分显示了在Delta域内用LMI方法设计的优越性;比较好地给出了随机滤波问题的解决办法,并用一个例子说明了本方法... 用LMI方法来研究Delta算子描述下的线性定常系统的H_∞滤波器问题,基于一个LMI给出了Delta域内的H_∞观测器型状态估计器,充分显示了在Delta域内用LMI方法设计的优越性;比较好地给出了随机滤波问题的解决办法,并用一个例子说明了本方法的有效性。 展开更多
关键词 LMI delta H∞滤波器 delta算子 H∞状态估计器 线性矩阵不等式 H∞控制理论
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广义Delta算子系统的非脆弱容许控制 被引量:4
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作者 张甜甜 董心壮 王文 《青岛大学学报(工程技术版)》 CAS 2015年第4期47-52,共6页
针对广义Delta算子系统的非脆弱控制问题,利用广义Delta算子系统容许的充要条件,给出系统广义二次容许的定义,以保证系统存在不确定时仍然容许,并采用线性矩阵不等式的方法,给出了广义Delta算子系统非脆弱状态反馈容许控制器存在的充分... 针对广义Delta算子系统的非脆弱控制问题,利用广义Delta算子系统容许的充要条件,给出系统广义二次容许的定义,以保证系统存在不确定时仍然容许,并采用线性矩阵不等式的方法,给出了广义Delta算子系统非脆弱状态反馈容许控制器存在的充分必要条件,同时利用线性矩阵不等式所得到的解,给出控制器的设计方法,使闭环系统广义二次容许,通过数值算例,对文中的理论结果进行仿真验证。仿真结果表明,当F=1,x1(0)=5以及F=-1,x1(0)=5的两种情况下,本文所设计的非脆弱控制器是可行有效的。因此,证明Delta算子方法在广义离散系统的非脆弱研究方面有很好的应用。 展开更多
关键词 广义delta算子系统 非脆弱容许控制 状态反馈 线性矩阵不等式
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Delta域内线性系统的H_2状态反馈控制
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作者 闫俊荣 闵勇 《自动化技术与应用》 2005年第7期19-21,25,共4页
基于LMI方法研究了Delta算子描述下的线性定常系统的H2控制问题,利用Schur补性质推导出状态反馈控制律存在的充分必要条件,用一个线性矩阵不等式的可行解给出了状态反馈控制律的一个参数化表示。
关键词 delta算子 状态反馈 H2范数 线性矩阵不等式
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导数项不确定广义Delta算子系统的鲁棒容许控制研究
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作者 高祯 董心壮 欧洋 《青岛大学学报(工程技术版)》 CAS 2017年第2期33-37,共5页
针对导数项不确定的广义Delta算子系统,本文采用导数反馈控制器,对广义Delta算子系统的鲁棒容许控制问题进行研究。以Delta算子相关理论以及广义二次容许充要条件为依据,采用线性矩阵不等式方法,得出广义Delta算子系统具有鲁棒容许性能... 针对导数项不确定的广义Delta算子系统,本文采用导数反馈控制器,对广义Delta算子系统的鲁棒容许控制问题进行研究。以Delta算子相关理论以及广义二次容许充要条件为依据,采用线性矩阵不等式方法,得出广义Delta算子系统具有鲁棒容许性能存在的充分条件。在此理论基础上,进一步设计导数项不确定的广义Delta算子系统的导数反馈控制器,给出闭环系统具有鲁棒容许性能的条件和设计方法,同时给出具体实例,利用Matlab-LMI对所得结论进行仿真验证。仿真结果表明,闭环导数项不确定广义Delta算子系统具有鲁棒容许性能,本文所设计的导数反馈控制器可行。因此,证明Delta算子方法在导数项不确定的广义Delta算子系统上可以良好运用,该研究具有可实施性和有效性。 展开更多
关键词 广义delta算子系统 鲁棒容许控制 导数反馈控制器 线性矩阵不等式
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Delta域离散系统的状态观测器设计
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作者 杨晨影 《信息技术》 2006年第12期131-132,136,共3页
在Delta域内设计系统状态观测器,得出了Z域状态观测器反馈矩阵和Delta域反馈阵的关系,并通过实例进行验证。
关键词 delta Z域 状态观测器
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广义Delta算子系统的非脆弱H_∞控制
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作者 张甜甜 董心壮 王文 《青岛大学学报(工程技术版)》 CAS 2016年第2期20-25,共6页
针对广义Delta算子系统的非脆弱控制问题,本文主要对广义Delta算子系统的非脆弱状态反馈H_∞控制问题进行研究,其控制器增益矩阵分别包含加法摄动和乘法摄动两种不同的形式。利用线性矩阵不等式方法,给出广义Delta算子系统在上述两种摄... 针对广义Delta算子系统的非脆弱控制问题,本文主要对广义Delta算子系统的非脆弱状态反馈H_∞控制问题进行研究,其控制器增益矩阵分别包含加法摄动和乘法摄动两种不同的形式。利用线性矩阵不等式方法,给出广义Delta算子系统在上述两种摄动的影响下,非脆弱H_∞控制器存在的充要条件,并通过解线性矩阵不等式,得到了相应的控制器的设计方法,从而使闭环系统是广义二次容许的,且具有指定的H_∞性能,并通过数值算例,对文中的理论结果进行仿真验证。仿真结果表明,本文所设计的非脆弱控制器具有可行性和有效性。该研究具有实际应用价值。 展开更多
关键词 广义delta算子系统 非脆弱H∞控制 状态反馈 线性矩阵不等式(LMI)
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广义Delta算子系统的耗散性分析与控制 被引量:5
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作者 齐春明 董心壮 刘琳 《青岛大学学报(工程技术版)》 CAS 2014年第3期38-43,共6页
针对线性广义离散系统的耗散性分析与耗散性控制问题,本文采用Delta算子离散化方法,对广义Delta算子系统进行耗散性研究,对该系统进行耗散性分析,得到了使广义Delta算子系统容许且严格耗散的充分必要条件,对于非容许且严格耗散的广义De... 针对线性广义离散系统的耗散性分析与耗散性控制问题,本文采用Delta算子离散化方法,对广义Delta算子系统进行耗散性研究,对该系统进行耗散性分析,得到了使广义Delta算子系统容许且严格耗散的充分必要条件,对于非容许且严格耗散的广义Delta算子系统,给出了该系统存在状态反馈严格耗散控制器的充分条件及耗散控制器的设计方法。同时借助MATLAB-LMI工具箱,对给出的数值算例进行计算和验证,验证结果表明,所得闭环系统容许且严格耗散,证明Delta算子方法在广义离散系统的耗散性研究中应用良好,其为广义离散系统其它性能的研究提供了新思路。 展开更多
关键词 广义delta算子系统 容许性 严格耗散性 状态反馈 线性矩阵不等式(LMI)
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State feedback design for singularly perturbed system using unified approach 被引量:1
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作者 ChenxiaoCAI YunZOU DuanjinZHANG 《控制理论与应用(英文版)》 EI 2004年第3期276-280,共5页
The state feedback design for singularly perturbed systems described in Delta operator is considered. The composite state feedback controller for slow and fast subsystems is designed by using the direct method. The ob... The state feedback design for singularly perturbed systems described in Delta operator is considered. The composite state feedback controller for slow and fast subsystems is designed by using the direct method. The obtained results can bring previous conclusions of continuous and discrete time systems into the unified Delta framework. A simulation example is presented to demonstrate the validity and efficiency of the design. 展开更多
关键词 Singularly perturbed systems delta operator state feedback
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不确定Delta算子时滞系统鲁棒H_∞控制器设计 被引量:2
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作者 彭仁崇 林瑞全 杨富文 《集美大学学报(自然科学版)》 CAS 2008年第2期157-161,共5页
对一类由Delta算子描述的不确定时滞系统的鲁棒H∞状态反馈控制器设计问题进行研究,以线性矩阵不等式(LM I)形式给出控制器存在的条件,通过求解LMI得出控制器参数.最后以数值例子来说明该设计方法的有效性和可行性,所设计的H∞状态反馈... 对一类由Delta算子描述的不确定时滞系统的鲁棒H∞状态反馈控制器设计问题进行研究,以线性矩阵不等式(LM I)形式给出控制器存在的条件,通过求解LMI得出控制器参数.最后以数值例子来说明该设计方法的有效性和可行性,所设计的H∞状态反馈控制器不但保证对象参数不确定时闭环系统渐近稳定,而且具有所期望的H∞性能指标. 展开更多
关键词 delta算子 时滞系统 不确定系统 H∞控制 状态反馈
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广义Delta算子系统的容错控制研究
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作者 赵国朋 董心壮 +1 位作者 徐艳 孙玉娇 《青岛大学学报(工程技术版)》 CAS 2016年第4期46-51,共6页
为了解决广义Delta算子系统的容错控制问题,本文对广义Delta算子系统的容错控制器进行合理的设计,保证在执行器出现故障时相应的闭环系统始终是容许的。通过引入故障切换矩阵来描述系统的执行器故障,并利用线性矩阵不等式方法,得到了广... 为了解决广义Delta算子系统的容错控制问题,本文对广义Delta算子系统的容错控制器进行合理的设计,保证在执行器出现故障时相应的闭环系统始终是容许的。通过引入故障切换矩阵来描述系统的执行器故障,并利用线性矩阵不等式方法,得到了广义Delta算子系统存在容错控制器的充分必要条件,进一步利用线性矩阵不等式的解给出相应容错控制器的设计方法,同时利用数值算例对本文理论结果的有效性进行验证分析。分析结果表明,本文所设计的容错控制器可以保证闭环系统在执行器出现故障时始终是容许的,具有良好的可行性,说明该设计方法是有效的。该研究对广义Delta算子系统的容错控制具有一定的应用价值。 展开更多
关键词 广义delta算子系统 容错控制 状态反馈 LMI
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Solid-state synthesis of Sr-and Co-doped LaMnO_3 perovskites 被引量:1
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作者 马文会 谢刚 +1 位作者 陈书荣 崔衡 《中国有色金属学会会刊:英文版》 CSCD 2001年第6期904-907,共4页
The synthesis process for La 1- x Sr x Mn 1- y Co y O 3- δ ( x = 0.2, 0.3; y = 0.2, 0.8, designated as LSMC below) perovskite oxides prepared by solid state reaction was investigated using DSC/TG, XRD, EPMA and parti... The synthesis process for La 1- x Sr x Mn 1- y Co y O 3- δ ( x = 0.2, 0.3; y = 0.2, 0.8, designated as LSMC below) perovskite oxides prepared by solid state reaction was investigated using DSC/TG, XRD, EPMA and particle size analysis methods. It was found that LSMCs were all of single phase and the synthesis process might be divided into three stages: the decomposition of reactants, the formation of LaMn(Co)O 3 based oxides, and the formation of LSMC solid solution. Typical average and the peak value of particle size, and the specific surface area are 14.65?μm, 16.4?μm and 1.38?m 2/mL, respectively, for mixed reactants and are 23.81?μm, 32.11?μm and 0.5?m 2/mL, respectively, for powder synthesized at 1?200?℃ for 8?h in air. 展开更多
关键词 solid state reaction synthesis La 1- x Sr x Mn 1- y Co y O 3- δ perovskite intermediate temperature SOFCs
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Elaboration of Simplest Folding Structures in 2-Dimensional Lattice with Delta-Hemolysin and Its Variants in HP Model
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作者 Shaomin Yan Guang Wu 《Journal of Biomedical Science and Engineering》 2019年第5期293-309,共17页
Although the advanced 3-dimensional structure measurements provide more and more detailed structures in Protein Data Bank, the simplest 2-dimensional lattice model still looks meaningful because 2-dimensional structur... Although the advanced 3-dimensional structure measurements provide more and more detailed structures in Protein Data Bank, the simplest 2-dimensional lattice model still looks meaningful because 2-dimensional structures play a complementary role with respect to 3-dimensional structures. In this study, the folding structures of delta-hemolysin and its six variants were studied at 2-dimensional lattice, and their amino acid contacts in folding structures were considered according to HP model with the aid of normalized amino acid hydrophobicity index. The results showed that: 1) either delta-hemolysin or each of its variants could find any of its folding structure in one eighth of 1,129,718,145,924 folding structures because of symmetry, which reduces the time required for folding, 2) the impact of pH on folding structures is varying and associated directly with the amino acid sequence itself, 3) the changes in folding structures of variants appeared different case by case, and 4) the assigning of hydrophobicity index to each amino acid was a way to distinguish folding structures at the same native state. This study can help to understand the structure of delta-hemolysin, and such an analysis can shed lights on NP-problem listed in millennium prize because the HP folding in lattice belongs to a sub-problem of NP-problem. 展开更多
关键词 FOLDING Structure delta-Hemolysin HP Model HYDROPHOBICITY Index LATTICE Minimal Energy Native state
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