Deafblindness is more than the addition of hearing impairment plus vision impairment. The absence or impairment of both distance senses gives a condition which is more disabling than the sum of each. Deafblindness is ...Deafblindness is more than the addition of hearing impairment plus vision impairment. The absence or impairment of both distance senses gives a condition which is more disabling than the sum of each. Deafblindness is rare among young people but becomes frequent at higher ages. Deafblindness can be either congenital or acquired. The heterogeneity of the population has been reported to be huge. Different levels of vision and hearing loss, different use of language modality, different kinds and severity of additional disabilities, and different medical aetiology are some of the variables splitting the group. Research in deafblindness is still in it is advent due to a number of limitations and a lack of current scientific interest. Some of the challenges in deafblindness research are： lack of consensus on the definition of deafblindness; rareness of the condition which makes it diffcult to even gather just a small group to study; heterogeneity of the population; difficulties with using traditional functional assessment procedures; communication barriers; and the difficulties of interpretation of deafblind behavior. This editorial calls for more interest in deafblindness in general and for more international cooperation and innovative studies to overcome existing barriers：Cooperation on data collection to form big enough sample sizes; development of reliable and valid tests and assessment tools; development of new research methods and approaches.展开更多
Gastric cancer is one of the most common malignancies with poor prognosis.The use of organoids to simulate gastric cancer has rapidly developed over the past several years.Patient-derived gastric cancer organoids serv...Gastric cancer is one of the most common malignancies with poor prognosis.The use of organoids to simulate gastric cancer has rapidly developed over the past several years.Patient-derived gastric cancer organoids serve as in vitro models that closely mimics donor characteristics,ofering new opportunities for both basic and applied research.The“Human Gastric Cancer Organoid”is part of a series of guidelines for human gastric cancer organoids in China,jointly drafted by experts from the Chinese Society for Cell Biology and its branches,and initially released on October 29,2024.This standard outlines terminology,technical requirements,assessment protocols,and applies to production,evaluation procedures,and quality control for human gastric cancer organoids.The publication of this guideline aims to assist institutions in endorsing,establishing,and applying best practices,advancing the international standardiza-tion of human gastric cancer organoids for clinical development and therapeutic application.展开更多
文摘Deafblindness is more than the addition of hearing impairment plus vision impairment. The absence or impairment of both distance senses gives a condition which is more disabling than the sum of each. Deafblindness is rare among young people but becomes frequent at higher ages. Deafblindness can be either congenital or acquired. The heterogeneity of the population has been reported to be huge. Different levels of vision and hearing loss, different use of language modality, different kinds and severity of additional disabilities, and different medical aetiology are some of the variables splitting the group. Research in deafblindness is still in it is advent due to a number of limitations and a lack of current scientific interest. Some of the challenges in deafblindness research are： lack of consensus on the definition of deafblindness; rareness of the condition which makes it diffcult to even gather just a small group to study; heterogeneity of the population; difficulties with using traditional functional assessment procedures; communication barriers; and the difficulties of interpretation of deafblind behavior. This editorial calls for more interest in deafblindness in general and for more international cooperation and innovative studies to overcome existing barriers：Cooperation on data collection to form big enough sample sizes; development of reliable and valid tests and assessment tools; development of new research methods and approaches.
基金supported by grants from the National Natural Science Foun-dation of China(31988101 to Y.-G.C.,32300586 to Y.L.W.)the National Key Research and Development Program of China(2023YFA1800603 to Y.-G.C)+1 种基金Major Project of Guangzhou National Laboratory(GZNL2023A02008 to Y.L.W.)Young Talent Support Project of Guangzhou Association for Science and Technology(QT2024-019 to Y.L.W.)。
文摘Gastric cancer is one of the most common malignancies with poor prognosis.The use of organoids to simulate gastric cancer has rapidly developed over the past several years.Patient-derived gastric cancer organoids serve as in vitro models that closely mimics donor characteristics,ofering new opportunities for both basic and applied research.The“Human Gastric Cancer Organoid”is part of a series of guidelines for human gastric cancer organoids in China,jointly drafted by experts from the Chinese Society for Cell Biology and its branches,and initially released on October 29,2024.This standard outlines terminology,technical requirements,assessment protocols,and applies to production,evaluation procedures,and quality control for human gastric cancer organoids.The publication of this guideline aims to assist institutions in endorsing,establishing,and applying best practices,advancing the international standardiza-tion of human gastric cancer organoids for clinical development and therapeutic application.
