A reduction in adult neurogenesis is associated with behavioral abnormalities in patients with Alzheimer's disease.Consequently,enhancing adult neurogenesis represents a promising therapeutic approach for mitigati...A reduction in adult neurogenesis is associated with behavioral abnormalities in patients with Alzheimer's disease.Consequently,enhancing adult neurogenesis represents a promising therapeutic approach for mitigating disease symptoms and progression.Nonetheless,nonpharmacological interventions aimed at inducing adult neurogenesis are currently limited.Although individual non-pharmacological interventions,such as aerobic exercise,acousto-optic stimulation,and olfactory stimulation,have shown limited capacity to improve neurogenesis and cognitive function in patients with Alzheimer's disease,the therapeutic effect of a strategy that combines these interventions has not been fully explored.In this study,we observed an age-dependent decrease in adult neurogenesis and a concurrent increase in amyloid-beta accumulation in the hippocampus of amyloid precursor protein/presenilin 1 mice aged 2-8 months.Amyloid deposition became evident at 4 months,while neurogenesis declined by 6 months,further deteriorating as the disease progressed.However,following a 4-week multifactor stimulation protocol,which encompassed treadmill running(46 min/d,10 m/min,6 days per week),40 Hz acousto-optic stimulation(1 hour/day,6 days/week),and olfactory stimulation(1 hour/day,6 days/week),we found a significant increase in the number of newborn cells(5'-bromo-2'-deoxyuridine-positive cells),immature neurons(doublecortin-positive cells),newborn immature neurons(5'-bromo-2'-deoxyuridine-positive/doublecortin-positive cells),and newborn astrocytes(5'-bromo-2'-deoxyuridine-positive/glial fibrillary acidic protein-positive cells).Additionally,the amyloid-beta load in the hippocampus decreased.These findings suggest that multifactor stimulation can enhance adult hippocampal neurogenesis and mitigate amyloid-beta neuropathology in amyloid precursor protein/presenilin 1 mice.Furthermore,cognitive abilities were improved,and depressive symptoms were alleviated in amyloid precursor protein/presenilin 1 mice following multifactor stimulation,as evidenced by Morris water maze,novel object recognition,forced swimming test,and tail suspension test results.Notably,the efficacy of multifactor stimulation in consolidating immature neurons persisted for at least 2weeks after treatment cessation.At the molecular level,multifactor stimulation upregulated the expression of neuron-related proteins(NeuN,doublecortin,postsynaptic density protein-95,and synaptophysin),anti-apoptosis-related proteins(Bcl-2 and PARP),and an autophagyassociated protein(LC3B),while decreasing the expression of apoptosis-related proteins(BAX and caspase-9),in the hippocampus of amyloid precursor protein/presenilin 1 mice.These observations might be attributable to both the brain-derived neurotrophic factor-mediated signaling pathway and antioxidant pathways.Furthermore,serum metabolomics analysis indicated that multifactor stimulation regulated differentially expressed metabolites associated with cell apoptosis,oxidative damage,and cognition.Collectively,these findings suggest that multifactor stimulation is a novel non-invasive approach for the prevention and treatment of Alzheimer's disease.展开更多
High-resolution spectroscopy unveils the fundamental physics of quantum states,molecular dynamics,and energy transfers.Ideally,a higher spectral resolution over a broader bandwidth is the prerequisite,but traditional ...High-resolution spectroscopy unveils the fundamental physics of quantum states,molecular dynamics,and energy transfers.Ideally,a higher spectral resolution over a broader bandwidth is the prerequisite,but traditional spectroscopic techniques can only partially fulfill this requirement even with a bulky system.Here we report that a multi-frequency acousto-optic phase modulation at a chip-scale of soft polydimethylsiloxane can readily support a 200-times higher 0.5-MHz spectral resolution for the frequency-comb-based spectroscopy,while co-located plasmonic nanostructures mediate the strong light-matter interaction.These results suggest the potential of polydimethylsiloxane acousto-optic phase modulation for cost-effective,compact,multifunctional chip-scale tools in diverse applications such as quantum spectroscopy,high-finesse cavity analysis,and surface plasmonic spectroscopy.展开更多
In weak field limits,we compute the deflection angle of a gravitational decoupling extended black hole(BH)solution.We obtained the Gaussian optical curvature by examining the null geodesic equations with the help of G...In weak field limits,we compute the deflection angle of a gravitational decoupling extended black hole(BH)solution.We obtained the Gaussian optical curvature by examining the null geodesic equations with the help of Gauss-Bonnet theorem(GBT).We also looked into the deflection angle of light by a black hole in weak field limits with the use of the Gibbons-Werner method.We verify the graphical behavior of the black hole after determining the deflection angle of light.Additionally,in the presence of the plasma medium,we also determine the deflection angle of the light and examine its graphical behavior.Furthermore,we compute the Einstein ring via gravitational decoupling extended black hole solution.We also compute the quasi-periodic oscillations and discuss their graphical behavior.展开更多
Cold-flow experiments on planar Expansion Deflection(ED)nozzle flows are conducted under a simulated startup-shutdown process of rocket motors.The purpose is to investigate the flow and performance characteristics in ...Cold-flow experiments on planar Expansion Deflection(ED)nozzle flows are conducted under a simulated startup-shutdown process of rocket motors.The purpose is to investigate the flow and performance characteristics in ED nozzles,capture the behavior of shock flapping,and explore asymmetric flow dynamics utilizing a symmetric nozzle.A total pressure condition,characterized by rapid rise followed by a slow fall,is employed to simulate the continuous startup and shutdown processes.The schlieren imaging technique and high-frequency pressure transducers are employed to obtain the flow information.The experimental results indicate that the flow characteristics differ between the startup and shutdown processes with a hysteresis observed in the nozzle wake mode transition.During the startup process,the shock waves are pushed outward of the nozzle,while during the shutdown process,the flow propagates inward dominated by Mach stems.Counterintuitive results are demonstrated,namely,the mode transition is not the cause of the sudden thrust decrease,and the moment of maximum thrust does not coincide with the moment of maximum total pressure.During the operation of the nozzle,two stages of shock wave flapping occur,accompanied by significant wall pressure oscillations.These oscillation frequencies are demonstrated to be related to the inherent acoustic frequencies of the test chamber.An improved pressure ratio method is proposed to predict the position of the shock oscillation separation point.The prediction results revealed the shock behavior during the flapping process.展开更多
The challenge of solving nonlinear problems in multi-connected domains with high accuracy has garnered significant interest.In this paper,we propose a unified wavelet solution method for accurately solving nonlinear b...The challenge of solving nonlinear problems in multi-connected domains with high accuracy has garnered significant interest.In this paper,we propose a unified wavelet solution method for accurately solving nonlinear boundary value problems on a two-dimensional(2D)arbitrary multi-connected domain.We apply this method to solve large deflection bending problems of complex plates with holes.Our solution method simplifies the treatment of the 2D multi-connected domain by utilizing a natural discretization approach that divides it into a series of one-dimensional(1D)intervals.This approach establishes a fundamental relationship between the highest-order derivative in the governing equation of the problem and the remaining lower-order derivatives.By combining a wavelet high accuracy integral approximation format on 1D intervals,where the convergence order remains constant regardless of the number of integration folds,with the collocation method,we obtain a system of algebraic equations that only includes discrete point values of the highest order derivative.In this process,the boundary conditions are automatically replaced using integration constants,eliminating the need for additional processing.Error estimation and numerical results demonstrate that the accuracy of this method is unaffected by the degree of nonlinearity of the equations.When solving the bending problem of multi-perforated complex-shaped plates under consideration,it is evident that directly using higher-order derivatives as unknown functions significantly improves the accuracy of stress calculation,even when the stress exhibits large gradient variations.Moreover,compared to the finite element method,the wavelet method requires significantly fewer nodes to achieve the same level of accuracy.Ultimately,the method achieves a sixth-order accuracy and resembles the treatment of one-dimensional problems during the solution process,effectively avoiding the need for the complex 2D meshing process typically required by conventional methods when solving problems with multi-connected domains.展开更多
Based on the equivalence principle of deflection and stress, the concentrated vehicle load which acts on the center of continuously reinforced concrete pavement （CRCP） is translated into the equivalent half-wave sin...Based on the equivalence principle of deflection and stress, the concentrated vehicle load which acts on the center of continuously reinforced concrete pavement （CRCP） is translated into the equivalent half-wave sine load by the Fourier transform. On the basis of this transform and the small deflection theory of elastic thin plates, the deflection and stress formulae of CRCP under the concentrated vehicle load with a hollow foundation are put forward. The sensitivity of parameters is analyzed. The results show that maximum deflection is directly proportional to the concentrated vehicle load and the slab width, and inversely proportional to the lateral bending stiffness and slab thickness. The effects of slab width and thickness are significant with regard to maximum deflection. Maximum stress is directly proportional to the concentrated vehicle load and the slab width as well as inversely proportional to slab thickness. The effect of slab thickness is significant with regard to maximum stress. According to the calculation results, the most effective measure to reduce maximum deflection and stress is to increase slab thickness.展开更多
Distributed X-ray sources comprise a single vacuum chamber containing multiple X-ray sources that are triggered and emit X-rays at a specific time and location. This process facilitates an application for innovative s...Distributed X-ray sources comprise a single vacuum chamber containing multiple X-ray sources that are triggered and emit X-rays at a specific time and location. This process facilitates an application for innovative system concepts in X-ray and computer tomography. This paper proposes a novel electron beam focusing, shaping,and deflection electron gun for distributed X-ray sources.The electron gun uses a dispenser cathode as an electron emitter, a mesh grid to control emission current, and two electrostatic lenses for beam shaping, focusing, and deflection. Novel focusing and deflecting electrodes were designed to increase the number of focal spots in the distributed source. Two identical half-rectangle opening electrodes are controlled by adjusting the potential of the two electrodes to control the electron beam trajectory, and then, multifocal spots are obtained on the anode target. The electron gun can increase the spatial density of the distributed X-ray sources, thereby improving the image quality. The beam experimental results show that the focal spot sizes of the deflected(deflected amplitude 10.5 mm)and non-deflected electron beams at full width at half maximum are 0.80 mm 90.50 mm and 0.55 mm 90.40 mm, respectively(anode voltage 160 kV; beam current 30 mA). The imaging experimental results demonstrate the excellent spatial resolution and time resolution of an imaging system built with the sources, which has an excellent imaging effect on a field-programmable gate array chip and a rotating metal disk.展开更多
In practical application, it is very important to master the influence of structure parameters on the mid-span deflection quantificationally. For large-span and heavy-duty gantry cranes, the influence of the rigid leg...In practical application, it is very important to master the influence of structure parameters on the mid-span deflection quantificationally. For large-span and heavy-duty gantry cranes, the influence of the rigid leg and the soft leg on mid-span deflection has not been considered in the past. In the paper, the mathematical model is established for universal large-span and heavy-duty gantry cranes. The analytical solution for the mid-span deflection of gantry-frame structure girder is derived and obtained based on the variation principle by considering the coupling effect of the bending moments of girder and legs, the axial force and the secondary bending moments. The relation between the load and the deflection on the mid-span of the gantry-frame structure girder is known. Then, the experimental model is designed according to dimensional analysis method. And experiments were performed on the WEW-600 B type testing machine. Hackling experimental data, the regular of the load and deflection on the girder mid-span is obtained, namely, the deformation of the gantry-frame structure resists the external load to do work. The validity of the nonlinear analytical solution of the girder deflection is verified. Experimental results show that the analytical solution of the gantry-frame structure deflection has much higher calculation accuracy than previous calculation method. This work provides a theoretical basis for the design and inspection of gantry-frame structures.展开更多
The solution and computational aspects on nonlinear deflection of Yongjiang Railway Bridge in Ningbo were investigated. An approximate iteration algorithm on nonlinear governing equation was presented, and the obtaine...The solution and computational aspects on nonlinear deflection of Yongjiang Railway Bridge in Ningbo were investigated. An approximate iteration algorithm on nonlinear governing equation was presented, and the obtained results show that, if altitude difference and span of the riverbanks are taken as 5 meters and 100 meters, respectively, the maximum gradient in the middle of the bridge exceeds 5%, much larger than maximum allowance gradient in railway design code. Therefore, a new solution scheme for decreasing gradient of the bridge is put forward, that is, the altitude difference between two riverbanks can be decreased to about 1/10 of the initial magnitude by building roadbeds with 0.5% gradient and 1 kilometer length at two riverbanks. As a direct result, the deflection gradient of the railway bridge is much reduced and the value is between 0.5% similar to 0.6%.展开更多
In flatness measuring system, the flatness measuring signal can be affected by the deflection of flatness measuring roll. The stress on flatness measuring roll was analyzed and a deflection model for the flatness meas...In flatness measuring system, the flatness measuring signal can be affected by the deflection of flatness measuring roll. The stress on flatness measuring roll was analyzed and a deflection model for the flatness measuring roll was obtained by using the influence function method. The model was developed on the basis of the deformation of flatness measuring roll in roiling process and compensation curve was obtained. The results indicated that the set curve of flatness is in good agreement with the online measured curve of flatness, and good strip flatness can be obtained.展开更多
Based on the three-phase model, the propagation behavior of a matrix crack in an intelligent coating system is investigated by an energy criterion. The effect of the elastic mismatch parameters and the thickness of th...Based on the three-phase model, the propagation behavior of a matrix crack in an intelligent coating system is investigated by an energy criterion. The effect of the elastic mismatch parameters and the thickness of the interface layer on the ratio of the energy release rate for infinitesimal deflected and penetrated crack is evaluated with the finite element method. The results show that the ratio of the energy release rates strongly depends on the elastic mismatch al between the substrate and the driving layer. It also strongly depends on the elastic mismatch a2 between the driving layer and the sensing layer for a thinner driving layer when a primary crack reaches an interface between the substrate and the driving layer. Moreover, with the increase in the thickness of the driving layer, the dependence on a2 gradually decreases. The experimental observation on aluminum alloys monitored with intelligent coating shows that the established model can better explain the behavior of matrix crack penetration and can be used in optimization design of intelligent coating.展开更多
In this paper we present the control and synchronization of a coupled Bragg acousto-optic bistable map system using nonlinear feedback technology. This nonlinear feedback technology is useful to control a temporally c...In this paper we present the control and synchronization of a coupled Bragg acousto-optic bistable map system using nonlinear feedback technology. This nonlinear feedback technology is useful to control a temporally chaotic system as well as a spatiotemporally chaotic system. It can be extended to synchronize the spatiotemporal chaos. It can work in a wide range of the controlled and synchronized signals, so it can decrease the sensitivity down to a noise level. The synchronization can be obtained by the analysis of the largest conditional Lyapunov exponent spectrum, and easily implemented in practical systems just by adjusting the coupled strength without any pre-knowledge of the dynamic system required.展开更多
Various kinds of deflection characteristics on the steel cable-stayed bridge(Nanjing No.3 Yangtze River Bridge)are investigated by different mathematical statistical methods.Firstly,via Pearson correlation coefficient...Various kinds of deflection characteristics on the steel cable-stayed bridge(Nanjing No.3 Yangtze River Bridge)are investigated by different mathematical statistical methods.Firstly,via Pearson correlation coefficient calculation,it shows good consistency between the adjacent measuring point of side span or middle span.Secondly,taking mid-span deflection as an example,the correlation analysis of deflection and temperature is conducted.They are synchronous via cross correlation coefficient calculation but not completely linear and a"hysteresis loop"phenomenon of three stages is formed.The fitting result on the monitoring data at day time is consistent with the numerical value through the application of unit temperature difference between the cable and girder and the positive temperature gradient of girder in the finite element model.And the temperature effect is considerable.Vehicle loads effect is obtained from wavelet analysis.The extracted curve can indirectly reflect the change of traffic loads.Finally,the structural damage is analyzed through the trend fusion on the deflection,cable force and visual inspection from 2006 to 2015.Relevant conclusions can provide a basis for management departments to carry out special detection.展开更多
In this paper, the differential equations of flexible circular plates with initial deflection are derived. The stability of motion is investigated in phase plane. The periodical solutions of nonlinear vibration for ci...In this paper, the differential equations of flexible circular plates with initial deflection are derived. The stability of motion is investigated in phase plane. The periodical solutions of nonlinear vibration for circular plates with initial deflection are obtained by use of Galerkin method and Lindstedt-Poincare perturbation method. The effect of initial deflection on the dynamic behavior of the flexible plates are also discussed.展开更多
The large deflection problem of cantilever beams was studied by means of the biparametric perturbation method and the first order derivative substitution from pseudolinear analysis approach. This kind of substitution ...The large deflection problem of cantilever beams was studied by means of the biparametric perturbation method and the first order derivative substitution from pseudolinear analysis approach. This kind of substitution can transform the basic equation, an integral differential equation into nonlinear algebraic ones, thus simplify computational process. Compared with present results, it indicates that the large deflection problem solved by using pseudolinear analysis can lead to simple and precise results.展开更多
The large deflection of an axially extensible curved beam with a rectangular cross-section is investigated. The elastic beam is assumed to satisfy the Euler-Bernoulli postulation and be made of the Ludwick type materi...The large deflection of an axially extensible curved beam with a rectangular cross-section is investigated. The elastic beam is assumed to satisfy the Euler-Bernoulli postulation and be made of the Ludwick type material. Through reasonably simplified integration, the strain and curvature of the axis of the beam are presented in implicit formulations. The governing equations involving both geometric and material nonlin- earities of the curved beam are derived and solved by the shooting method. When the initial curvature of the beam is zero, the curved beam is degenerated into a straight beam, and the predicted results obtained by the present model are consistent with those in the open literature. Numerical examples are further given for curved cantilever and simply supported beams, and the couplings between elongation and bending are found for the curved beams.展开更多
In an open-circuit dissipative photovoltaic （PV） crystal, by considering the diffusion effect, the deflection of bright dissipative photovoltaic （DPV） solitons has been investigated by employing numerical techniqu...In an open-circuit dissipative photovoltaic （PV） crystal, by considering the diffusion effect, the deflection of bright dissipative photovoltaic （DPV） solitons has been investigated by employing numerical technique and perturbational procedure. The relevant results show that the centre of the optical beam moves along a parabolic trajectory, while the central spatial-frequency component shifts linearly with the propagation distance; furthermore, both the spatial deflection and the angular derivation are associated with the photovoltaic field. Such DPV solitons have a fixed deflection degree completely determined by the parameters of the dissipative system. The small bending cannot affect the formation of the DPV soliton via two-wave mixing.展开更多
An embedded cylinder is a large-diameter cylinder embedded in a soil foundation. The state of failure of such an embedded cylindrical structure shows large deflection instead of slide and overturn of the traditional g...An embedded cylinder is a large-diameter cylinder embedded in a soil foundation. The state of failure of such an embedded cylindrical structure shows large deflection instead of slide and overturn of the traditional gravity type of structure placed on a rubble base or foundation base. The critical value of deflection of the embedded cylindrical structure, which is the maximum allowable deflection for stability calculation of the cylinder, is a vital control value. Through investigation on deflection and soil pressures on an embedded cylinder by model experiments, the variations of the angle of rotation θ of a cylinder with effective anti-overturning ratio η and moment MH of thrust are discussed. On the basis of experimental study, the critical value of deflection of the cylindrical structure is proposed in the paper. Meanwhile, the formulas for calculating deflection of cylinders are derived.展开更多
Nano-3D printing has obtained widespread attention owing to its capacity to manufacture end-use components with nano-scale features in recent years.Multiphoton lithography(MPL)is one of the most promising 3D nanomanuf...Nano-3D printing has obtained widespread attention owing to its capacity to manufacture end-use components with nano-scale features in recent years.Multiphoton lithography(MPL)is one of the most promising 3D nanomanufacturing technologies,which has been widely used in manufacturing micro-optics,photonic crystals,microfluidics,meta-surface,and mechanical metamaterials.Despite of tremendous potential of MPL in laboratorial and industrial applications,simultaneous achievement of high throughput,high accuracy,high design freedom,and a broad range of material structuring capabilities remains a long-pending challenge.To address the issue,we propose an acousto-optic scanning with spatial-switching multispots(AOSS)method.Inertia-free acousto-optic scanning and nonlinear swept techniques have been developed for achieving ultrahigh-speed and aberration-free scanning.Moreover,a spatial optical switch concept has been implemented to significantly boost the lithography throughput while maintaining high resolution and high design freedom.An eight-foci AOSS system has demonstrated a record-high 3D printing rate of 7.6×10^(7)voxel s^(-1),which is nearly one order of magnitude higher than earlier scanning MPL,exhibiting its promise for future scalable 3D nanomanufacturing.展开更多
This paper adopts the NGI-ADP soil model to carry out finite element analysis,based on which the effects of soft clay anisotropy on the diaphragm wall deflections in the braced excavation were evaluated.More than one ...This paper adopts the NGI-ADP soil model to carry out finite element analysis,based on which the effects of soft clay anisotropy on the diaphragm wall deflections in the braced excavation were evaluated.More than one thousand finite element cases were numerically analyzed,followed by extensive parametric studies.Surrogate models were developed via ensemble learning methods(ELMs),including the e Xtreme Gradient Boosting(XGBoost),and Random Forest Regression(RFR)to predict the maximum lateral wall deformation(δhmax).Then the results of ELMs were compared with conventional soft computing methods such as Decision Tree Regression(DTR),Multilayer Perceptron Regression(MLPR),and Multivariate Adaptive Regression Splines(MARS).This study presents a cutting-edge application of ensemble learning in geotechnical engineering and a reasonable methodology that allows engineers to determine the wall deflection in a fast,alternative way.展开更多
基金supported by the National Natural Science Foundation of China,No.82001155(to LL)the Natural Science Foundation of Zhejiang Province,No.LY23H090004(to LL)+5 种基金the Natural Science Foundation of Ningbo,No.2023J068(to LL)the Fundamental Research Funds for the Provincial Universities of Zhejiang Province,No.SJLY2023008(to LL)the College Students'Scientific and Technological Innovation Project(Xin Miao Talent Plan)of Zhejiang Province,No.2022R405A045(to CC)the Student ResearchInnovation Program(SRIP)of Ningbo University,Nos.20235RIP1919(to CZ),2023SRIP1938(to YZ)the K.C.Wong Magna Fund in Ningbo University。
文摘A reduction in adult neurogenesis is associated with behavioral abnormalities in patients with Alzheimer's disease.Consequently,enhancing adult neurogenesis represents a promising therapeutic approach for mitigating disease symptoms and progression.Nonetheless,nonpharmacological interventions aimed at inducing adult neurogenesis are currently limited.Although individual non-pharmacological interventions,such as aerobic exercise,acousto-optic stimulation,and olfactory stimulation,have shown limited capacity to improve neurogenesis and cognitive function in patients with Alzheimer's disease,the therapeutic effect of a strategy that combines these interventions has not been fully explored.In this study,we observed an age-dependent decrease in adult neurogenesis and a concurrent increase in amyloid-beta accumulation in the hippocampus of amyloid precursor protein/presenilin 1 mice aged 2-8 months.Amyloid deposition became evident at 4 months,while neurogenesis declined by 6 months,further deteriorating as the disease progressed.However,following a 4-week multifactor stimulation protocol,which encompassed treadmill running(46 min/d,10 m/min,6 days per week),40 Hz acousto-optic stimulation(1 hour/day,6 days/week),and olfactory stimulation(1 hour/day,6 days/week),we found a significant increase in the number of newborn cells(5'-bromo-2'-deoxyuridine-positive cells),immature neurons(doublecortin-positive cells),newborn immature neurons(5'-bromo-2'-deoxyuridine-positive/doublecortin-positive cells),and newborn astrocytes(5'-bromo-2'-deoxyuridine-positive/glial fibrillary acidic protein-positive cells).Additionally,the amyloid-beta load in the hippocampus decreased.These findings suggest that multifactor stimulation can enhance adult hippocampal neurogenesis and mitigate amyloid-beta neuropathology in amyloid precursor protein/presenilin 1 mice.Furthermore,cognitive abilities were improved,and depressive symptoms were alleviated in amyloid precursor protein/presenilin 1 mice following multifactor stimulation,as evidenced by Morris water maze,novel object recognition,forced swimming test,and tail suspension test results.Notably,the efficacy of multifactor stimulation in consolidating immature neurons persisted for at least 2weeks after treatment cessation.At the molecular level,multifactor stimulation upregulated the expression of neuron-related proteins(NeuN,doublecortin,postsynaptic density protein-95,and synaptophysin),anti-apoptosis-related proteins(Bcl-2 and PARP),and an autophagyassociated protein(LC3B),while decreasing the expression of apoptosis-related proteins(BAX and caspase-9),in the hippocampus of amyloid precursor protein/presenilin 1 mice.These observations might be attributable to both the brain-derived neurotrophic factor-mediated signaling pathway and antioxidant pathways.Furthermore,serum metabolomics analysis indicated that multifactor stimulation regulated differentially expressed metabolites associated with cell apoptosis,oxidative damage,and cognition.Collectively,these findings suggest that multifactor stimulation is a novel non-invasive approach for the prevention and treatment of Alzheimer's disease.
基金supported by BrainLink program funded by the Ministry of Science and ICT through the National Research Foundation of Korea(RS-2023-00236798)BK21 FOUR Program by Pusan National University Research Grant,2021+1 种基金This work was supported by the National Research Foundation(NRF)grant funded by the Korean government(RS-2024-00336583)the Korea government(MSIT)(No.RS-2024-00406152).
文摘High-resolution spectroscopy unveils the fundamental physics of quantum states,molecular dynamics,and energy transfers.Ideally,a higher spectral resolution over a broader bandwidth is the prerequisite,but traditional spectroscopic techniques can only partially fulfill this requirement even with a bulky system.Here we report that a multi-frequency acousto-optic phase modulation at a chip-scale of soft polydimethylsiloxane can readily support a 200-times higher 0.5-MHz spectral resolution for the frequency-comb-based spectroscopy,while co-located plasmonic nanostructures mediate the strong light-matter interaction.These results suggest the potential of polydimethylsiloxane acousto-optic phase modulation for cost-effective,compact,multifunctional chip-scale tools in diverse applications such as quantum spectroscopy,high-finesse cavity analysis,and surface plasmonic spectroscopy.
基金funded by the National Natural Science Foundation of China under Grant No.11975145。
文摘In weak field limits,we compute the deflection angle of a gravitational decoupling extended black hole(BH)solution.We obtained the Gaussian optical curvature by examining the null geodesic equations with the help of Gauss-Bonnet theorem(GBT).We also looked into the deflection angle of light by a black hole in weak field limits with the use of the Gibbons-Werner method.We verify the graphical behavior of the black hole after determining the deflection angle of light.Additionally,in the presence of the plasma medium,we also determine the deflection angle of the light and examine its graphical behavior.Furthermore,we compute the Einstein ring via gravitational decoupling extended black hole solution.We also compute the quasi-periodic oscillations and discuss their graphical behavior.
基金supported by the National Natural Science Foundation of China(No.12002102)。
文摘Cold-flow experiments on planar Expansion Deflection(ED)nozzle flows are conducted under a simulated startup-shutdown process of rocket motors.The purpose is to investigate the flow and performance characteristics in ED nozzles,capture the behavior of shock flapping,and explore asymmetric flow dynamics utilizing a symmetric nozzle.A total pressure condition,characterized by rapid rise followed by a slow fall,is employed to simulate the continuous startup and shutdown processes.The schlieren imaging technique and high-frequency pressure transducers are employed to obtain the flow information.The experimental results indicate that the flow characteristics differ between the startup and shutdown processes with a hysteresis observed in the nozzle wake mode transition.During the startup process,the shock waves are pushed outward of the nozzle,while during the shutdown process,the flow propagates inward dominated by Mach stems.Counterintuitive results are demonstrated,namely,the mode transition is not the cause of the sudden thrust decrease,and the moment of maximum thrust does not coincide with the moment of maximum total pressure.During the operation of the nozzle,two stages of shock wave flapping occur,accompanied by significant wall pressure oscillations.These oscillation frequencies are demonstrated to be related to the inherent acoustic frequencies of the test chamber.An improved pressure ratio method is proposed to predict the position of the shock oscillation separation point.The prediction results revealed the shock behavior during the flapping process.
基金supported by the National Natural Science Foundation of China(Grant No.11925204).
文摘The challenge of solving nonlinear problems in multi-connected domains with high accuracy has garnered significant interest.In this paper,we propose a unified wavelet solution method for accurately solving nonlinear boundary value problems on a two-dimensional(2D)arbitrary multi-connected domain.We apply this method to solve large deflection bending problems of complex plates with holes.Our solution method simplifies the treatment of the 2D multi-connected domain by utilizing a natural discretization approach that divides it into a series of one-dimensional(1D)intervals.This approach establishes a fundamental relationship between the highest-order derivative in the governing equation of the problem and the remaining lower-order derivatives.By combining a wavelet high accuracy integral approximation format on 1D intervals,where the convergence order remains constant regardless of the number of integration folds,with the collocation method,we obtain a system of algebraic equations that only includes discrete point values of the highest order derivative.In this process,the boundary conditions are automatically replaced using integration constants,eliminating the need for additional processing.Error estimation and numerical results demonstrate that the accuracy of this method is unaffected by the degree of nonlinearity of the equations.When solving the bending problem of multi-perforated complex-shaped plates under consideration,it is evident that directly using higher-order derivatives as unknown functions significantly improves the accuracy of stress calculation,even when the stress exhibits large gradient variations.Moreover,compared to the finite element method,the wavelet method requires significantly fewer nodes to achieve the same level of accuracy.Ultimately,the method achieves a sixth-order accuracy and resembles the treatment of one-dimensional problems during the solution process,effectively avoiding the need for the complex 2D meshing process typically required by conventional methods when solving problems with multi-connected domains.
基金The Science Foundation of Ministry of Transport of the People's Republic of China(No.200731822301-7)
文摘Based on the equivalence principle of deflection and stress, the concentrated vehicle load which acts on the center of continuously reinforced concrete pavement （CRCP） is translated into the equivalent half-wave sine load by the Fourier transform. On the basis of this transform and the small deflection theory of elastic thin plates, the deflection and stress formulae of CRCP under the concentrated vehicle load with a hollow foundation are put forward. The sensitivity of parameters is analyzed. The results show that maximum deflection is directly proportional to the concentrated vehicle load and the slab width, and inversely proportional to the lateral bending stiffness and slab thickness. The effects of slab width and thickness are significant with regard to maximum deflection. Maximum stress is directly proportional to the concentrated vehicle load and the slab width as well as inversely proportional to slab thickness. The effect of slab thickness is significant with regard to maximum stress. According to the calculation results, the most effective measure to reduce maximum deflection and stress is to increase slab thickness.
文摘Distributed X-ray sources comprise a single vacuum chamber containing multiple X-ray sources that are triggered and emit X-rays at a specific time and location. This process facilitates an application for innovative system concepts in X-ray and computer tomography. This paper proposes a novel electron beam focusing, shaping,and deflection electron gun for distributed X-ray sources.The electron gun uses a dispenser cathode as an electron emitter, a mesh grid to control emission current, and two electrostatic lenses for beam shaping, focusing, and deflection. Novel focusing and deflecting electrodes were designed to increase the number of focal spots in the distributed source. Two identical half-rectangle opening electrodes are controlled by adjusting the potential of the two electrodes to control the electron beam trajectory, and then, multifocal spots are obtained on the anode target. The electron gun can increase the spatial density of the distributed X-ray sources, thereby improving the image quality. The beam experimental results show that the focal spot sizes of the deflected(deflected amplitude 10.5 mm)and non-deflected electron beams at full width at half maximum are 0.80 mm 90.50 mm and 0.55 mm 90.40 mm, respectively(anode voltage 160 kV; beam current 30 mA). The imaging experimental results demonstrate the excellent spatial resolution and time resolution of an imaging system built with the sources, which has an excellent imaging effect on a field-programmable gate array chip and a rotating metal disk.
基金Project(51175442)supported by the National Natural Science Foundation of ChinaProject(QD2012A09)supported by Teachers’College Research Project,ChinaProject(14ZA0263)supported by Research Project of Sichuan Provincial Department of Education,China
文摘In practical application, it is very important to master the influence of structure parameters on the mid-span deflection quantificationally. For large-span and heavy-duty gantry cranes, the influence of the rigid leg and the soft leg on mid-span deflection has not been considered in the past. In the paper, the mathematical model is established for universal large-span and heavy-duty gantry cranes. The analytical solution for the mid-span deflection of gantry-frame structure girder is derived and obtained based on the variation principle by considering the coupling effect of the bending moments of girder and legs, the axial force and the secondary bending moments. The relation between the load and the deflection on the mid-span of the gantry-frame structure girder is known. Then, the experimental model is designed according to dimensional analysis method. And experiments were performed on the WEW-600 B type testing machine. Hackling experimental data, the regular of the load and deflection on the girder mid-span is obtained, namely, the deformation of the gantry-frame structure resists the external load to do work. The validity of the nonlinear analytical solution of the girder deflection is verified. Experimental results show that the analytical solution of the gantry-frame structure deflection has much higher calculation accuracy than previous calculation method. This work provides a theoretical basis for the design and inspection of gantry-frame structures.
文摘The solution and computational aspects on nonlinear deflection of Yongjiang Railway Bridge in Ningbo were investigated. An approximate iteration algorithm on nonlinear governing equation was presented, and the obtained results show that, if altitude difference and span of the riverbanks are taken as 5 meters and 100 meters, respectively, the maximum gradient in the middle of the bridge exceeds 5%, much larger than maximum allowance gradient in railway design code. Therefore, a new solution scheme for decreasing gradient of the bridge is put forward, that is, the altitude difference between two riverbanks can be decreased to about 1/10 of the initial magnitude by building roadbeds with 0.5% gradient and 1 kilometer length at two riverbanks. As a direct result, the deflection gradient of the railway bridge is much reduced and the value is between 0.5% similar to 0.6%.
基金Item Sponsored by National Natural Science Foundation of China(50534020)
文摘In flatness measuring system, the flatness measuring signal can be affected by the deflection of flatness measuring roll. The stress on flatness measuring roll was analyzed and a deflection model for the flatness measuring roll was obtained by using the influence function method. The model was developed on the basis of the deformation of flatness measuring roll in roiling process and compensation curve was obtained. The results indicated that the set curve of flatness is in good agreement with the online measured curve of flatness, and good strip flatness can be obtained.
基金Project supported by the National Natural Science Foundation of China(No.51175404)
文摘Based on the three-phase model, the propagation behavior of a matrix crack in an intelligent coating system is investigated by an energy criterion. The effect of the elastic mismatch parameters and the thickness of the interface layer on the ratio of the energy release rate for infinitesimal deflected and penetrated crack is evaluated with the finite element method. The results show that the ratio of the energy release rates strongly depends on the elastic mismatch al between the substrate and the driving layer. It also strongly depends on the elastic mismatch a2 between the driving layer and the sensing layer for a thinner driving layer when a primary crack reaches an interface between the substrate and the driving layer. Moreover, with the increase in the thickness of the driving layer, the dependence on a2 gradually decreases. The experimental observation on aluminum alloys monitored with intelligent coating shows that the established model can better explain the behavior of matrix crack penetration and can be used in optimization design of intelligent coating.
文摘In this paper we present the control and synchronization of a coupled Bragg acousto-optic bistable map system using nonlinear feedback technology. This nonlinear feedback technology is useful to control a temporally chaotic system as well as a spatiotemporally chaotic system. It can be extended to synchronize the spatiotemporal chaos. It can work in a wide range of the controlled and synchronized signals, so it can decrease the sensitivity down to a noise level. The synchronization can be obtained by the analysis of the largest conditional Lyapunov exponent spectrum, and easily implemented in practical systems just by adjusting the coupled strength without any pre-knowledge of the dynamic system required.
基金supported by the National Natural Science Foundation of China(Nos.51208096,51808301)
文摘Various kinds of deflection characteristics on the steel cable-stayed bridge(Nanjing No.3 Yangtze River Bridge)are investigated by different mathematical statistical methods.Firstly,via Pearson correlation coefficient calculation,it shows good consistency between the adjacent measuring point of side span or middle span.Secondly,taking mid-span deflection as an example,the correlation analysis of deflection and temperature is conducted.They are synchronous via cross correlation coefficient calculation but not completely linear and a"hysteresis loop"phenomenon of three stages is formed.The fitting result on the monitoring data at day time is consistent with the numerical value through the application of unit temperature difference between the cable and girder and the positive temperature gradient of girder in the finite element model.And the temperature effect is considerable.Vehicle loads effect is obtained from wavelet analysis.The extracted curve can indirectly reflect the change of traffic loads.Finally,the structural damage is analyzed through the trend fusion on the deflection,cable force and visual inspection from 2006 to 2015.Relevant conclusions can provide a basis for management departments to carry out special detection.
文摘In this paper, the differential equations of flexible circular plates with initial deflection are derived. The stability of motion is investigated in phase plane. The periodical solutions of nonlinear vibration for circular plates with initial deflection are obtained by use of Galerkin method and Lindstedt-Poincare perturbation method. The effect of initial deflection on the dynamic behavior of the flexible plates are also discussed.
文摘The large deflection problem of cantilever beams was studied by means of the biparametric perturbation method and the first order derivative substitution from pseudolinear analysis approach. This kind of substitution can transform the basic equation, an integral differential equation into nonlinear algebraic ones, thus simplify computational process. Compared with present results, it indicates that the large deflection problem solved by using pseudolinear analysis can lead to simple and precise results.
基金supported by the National Natural Science Foundation of China(Nos.11472035 and 11472034)
文摘The large deflection of an axially extensible curved beam with a rectangular cross-section is investigated. The elastic beam is assumed to satisfy the Euler-Bernoulli postulation and be made of the Ludwick type material. Through reasonably simplified integration, the strain and curvature of the axis of the beam are presented in implicit formulations. The governing equations involving both geometric and material nonlin- earities of the curved beam are derived and solved by the shooting method. When the initial curvature of the beam is zero, the curved beam is degenerated into a straight beam, and the predicted results obtained by the present model are consistent with those in the open literature. Numerical examples are further given for curved cantilever and simply supported beams, and the couplings between elongation and bending are found for the curved beams.
基金Project supported by the National Natural Science Foundation of China （Grant Nos 10574051 and 10174025）.
文摘In an open-circuit dissipative photovoltaic （PV） crystal, by considering the diffusion effect, the deflection of bright dissipative photovoltaic （DPV） solitons has been investigated by employing numerical technique and perturbational procedure. The relevant results show that the centre of the optical beam moves along a parabolic trajectory, while the central spatial-frequency component shifts linearly with the propagation distance; furthermore, both the spatial deflection and the angular derivation are associated with the photovoltaic field. Such DPV solitons have a fixed deflection degree completely determined by the parameters of the dissipative system. The small bending cannot affect the formation of the DPV soliton via two-wave mixing.
文摘An embedded cylinder is a large-diameter cylinder embedded in a soil foundation. The state of failure of such an embedded cylindrical structure shows large deflection instead of slide and overturn of the traditional gravity type of structure placed on a rubble base or foundation base. The critical value of deflection of the embedded cylindrical structure, which is the maximum allowable deflection for stability calculation of the cylinder, is a vital control value. Through investigation on deflection and soil pressures on an embedded cylinder by model experiments, the variations of the angle of rotation θ of a cylinder with effective anti-overturning ratio η and moment MH of thrust are discussed. On the basis of experimental study, the critical value of deflection of the cylindrical structure is proposed in the paper. Meanwhile, the formulas for calculating deflection of cylinders are derived.
基金National Key Research and Development Program of China(2021YFF0502700)National Natural Science Foundation of China(52275429,62205117)+4 种基金Innovation project of Optics Valley Laboratory(OVL2021ZD002)Hubei Provincial Natural Science Foundation of China(2022CFB792)Young Elite Scientists Sponsorship Program by CAST(2022QNRC001)West Light Foundation of the Chinese Academy of Sciences(xbzg-zdsys-202206)Knowledge Innovation Program of Wuhan-Shuguang。
文摘Nano-3D printing has obtained widespread attention owing to its capacity to manufacture end-use components with nano-scale features in recent years.Multiphoton lithography(MPL)is one of the most promising 3D nanomanufacturing technologies,which has been widely used in manufacturing micro-optics,photonic crystals,microfluidics,meta-surface,and mechanical metamaterials.Despite of tremendous potential of MPL in laboratorial and industrial applications,simultaneous achievement of high throughput,high accuracy,high design freedom,and a broad range of material structuring capabilities remains a long-pending challenge.To address the issue,we propose an acousto-optic scanning with spatial-switching multispots(AOSS)method.Inertia-free acousto-optic scanning and nonlinear swept techniques have been developed for achieving ultrahigh-speed and aberration-free scanning.Moreover,a spatial optical switch concept has been implemented to significantly boost the lithography throughput while maintaining high resolution and high design freedom.An eight-foci AOSS system has demonstrated a record-high 3D printing rate of 7.6×10^(7)voxel s^(-1),which is nearly one order of magnitude higher than earlier scanning MPL,exhibiting its promise for future scalable 3D nanomanufacturing.
基金supported by the High-end Foreign Expert Introduction program(No.G20190022002)Chongqing Construction Science and Technology Plan Project(2019-0045)+1 种基金the Science and Technology Research Program of Chongqing Municipal Education Commission(Grant No.KJZD-K201900102)The financial support is gratefully acknowledged。
文摘This paper adopts the NGI-ADP soil model to carry out finite element analysis,based on which the effects of soft clay anisotropy on the diaphragm wall deflections in the braced excavation were evaluated.More than one thousand finite element cases were numerically analyzed,followed by extensive parametric studies.Surrogate models were developed via ensemble learning methods(ELMs),including the e Xtreme Gradient Boosting(XGBoost),and Random Forest Regression(RFR)to predict the maximum lateral wall deformation(δhmax).Then the results of ELMs were compared with conventional soft computing methods such as Decision Tree Regression(DTR),Multilayer Perceptron Regression(MLPR),and Multivariate Adaptive Regression Splines(MARS).This study presents a cutting-edge application of ensemble learning in geotechnical engineering and a reasonable methodology that allows engineers to determine the wall deflection in a fast,alternative way.
