Objective:To observe the clinical effect and safety of Lu'e Biyan Formula(LBF)combined with loratadine in the treatment of moderate to severe allergic rhinitis(AR)patients with Fei(Lung)-qi deficiencycoldness(FQDC...Objective:To observe the clinical effect and safety of Lu'e Biyan Formula(LBF)combined with loratadine in the treatment of moderate to severe allergic rhinitis(AR)patients with Fei(Lung)-qi deficiencycoldness(FQDC)syndrome.Methods:From September 2023 to December 2024,moderate to severe AR patients with FQDC syndrome were recruited from the Outpatient Department of Integrated Traditional Chinese and Western Medicine for Pulmonary Diseases Part 1,China-Japan Friendship Hospital.Participants were randomly assigned to a test group and a control group by using a random number table at a ratio of 1:1.Both groups received oral loratadine tablets(10 mg,once daily)for 2 weeks.In addition,the test group received oral LBF(30 mL,twice daily),and the control group received a placebo of LBF.Changes in the Total Nasal Symptom Score(TNSS),Total Non-nasal Symptom Score(TNNSS),Visual Analog Scale(VAS),Rhinoconjunctivitis Quality of Life Questionnaire(RQLQ),and Chinese medicine(CM)syndrome scores before and after treatment were compared between groups.Moreover,the total effective rates and disease recurrence rates were compared.Adverse events(AEs)during the study period were also recorded.Results:Totally 109 participants were recruited,and the full analysis set included 105 cases,54 in the test group and 51 in the control group.Compared with the pre-treatment values,the scores of sneezing,runny nose,nasal obstruction,nasal itching,TNSS,TNNSS,VAS,RQLQ,and CM syndrome were significantly reduced in both groups at 1 and 2 weeks post-treatment and 12 weeks postdrug withdrawal(P<0.01).After treatment,the aforementioned scores in the test group were all markedly lower than those in the control group(P<0.01).Moreover,the total effective rate in the test group was higher than that in the control group(98.15%vs.70.59%,P<0.01).After 12 weeks of drug withdrawal,there was no significant difference in the recurrence rate between groups(13.21%vs.22.22%,P>0.05).No obvious AEs were observed in either group following treatment.Conclusions:The combination of LBF with loratadine can effectively alleviate the symptoms of moderate to severe AR patients with FQDC syndrome,thereby improving their quality of life.This therapy demonstrated both precise effect and high safety.(Trial registration No.ITMCTR2025000589)展开更多
To assess the efficacy and safety of Gastrosis No.1 compound in the treatment of functional dyspepsia with Spleen （Pi） and Stomach （Wei） deficiency-cold syndrome. Methods： A randomized, double-blind, placebo-cont...To assess the efficacy and safety of Gastrosis No.1 compound in the treatment of functional dyspepsia with Spleen （Pi） and Stomach （Wei） deficiency-cold syndrome. Methods： A randomized, double-blind, placebo-controlled trial was performed in 5 centers. Patients with functional dyspepsia （FD） of Spleen-deficiency and qi-stagnation syndrome （162 cases） were randomly assigned to groups given Chinese herbal medicine （CHM） Gastrosis No.1 compound or placebo in a 2：1 ratio. This trial included a 4-week treatment period and a 4-week follow-up period. The outcomes were the dyspepsia symptom scores （measured by total dyspepsia symptom scale and single dyspepsia symptom scale） and syndromes of traditional Chinese medicine score （measured by traditional Chinese medicine syndrome scale）. The outcomes were noted at weeks 0, 4 and 8. Results： Compared with patients in the placebo group, patients in the CHM group showed significant improvement in the dyspepsia symptom scores as rated by patients and investigators （P〈0.01）, and also showed improvement in syndromes of traditional Chinese medicine score （P〈0.01）. No serious adverse event was reported. Safety tests obtained after 4 weeks of treatment showed no abnormal values. Conclusion： CHM Gastrosis No.1 compound was effective and safe in the treatment of functional dyspepsia with Spleen and Stomach deficiency-cold syndrome.展开更多
Hot medicated cornpress treatment belongs to an external treatment and is a kindof moxibustion. ″Feng Qi Ai″ prescription was recorded in Yi Fang Lei Ju. Zhu Xu Men, Rui ZhuTang Fang. In the treatment, pain in the l...Hot medicated cornpress treatment belongs to an external treatment and is a kindof moxibustion. ″Feng Qi Ai″ prescription was recorded in Yi Fang Lei Ju. Zhu Xu Men, Rui ZhuTang Fang. In the treatment, pain in the loin and the knees, cold-pain around the navel and in theabdornen,diarrhea due to deficiency and cold and other diseases are treated by combination of drugswith hot compress- We have irnproved the treatment and extended the range of its indication. It wasused for treatment 0f menorrhalgia due to cold uterine, gastralgia due to coId of rniddle-jiao, sciatica’periarthritis of shoulder, systremma,piriformis syndrome with good results.展开更多
lasma cortisol levels and leukocyte glucocorticosteroid receptor (GCR) contents were assayed in 10 patients with Deficiency-Cold Syndrome, 10 patients with Deficiency-Heat Syndrome, and 10healthy subjects as normal co...lasma cortisol levels and leukocyte glucocorticosteroid receptor (GCR) contents were assayed in 10 patients with Deficiency-Cold Syndrome, 10 patients with Deficiency-Heat Syndrome, and 10healthy subjects as normal control. The results showed practically normal plasma cortisol levels in the De-ticiency-Cold Group, but the leukocyte GCR contents were markedly lowered. In the Deficiency-Heatgroup, plasma cortisol levels were remarkably elevated and the leukocyte GCR contents also tended to behigher than normal. The quantity of plasma cortisol concentrations multiplied by leukocyte GCR contentscan be taken as a sensitive index for the differentiation of Cold and Heat natures in Deficiency Syndromes.展开更多
In the treatment of 80 cases of the patients with deficient and cold pattern in the spleen and stomach by external application of herbal paste on the acupoints,the results showed remarkable effect in 52 cases,improvem...In the treatment of 80 cases of the patients with deficient and cold pattern in the spleen and stomach by external application of herbal paste on the acupoints,the results showed remarkable effect in 52 cases,improvement in 24 cases,failure in 4 cases and the total effective rate in 95.0%.Remarkable therapeutic effects were achieved in three different diseases of same pattern.External application of herbal paste on the acupoints is definitely effective for stomachache in deficient and cold pattern of the spleen and stomach.展开更多
基金Supported by the National Natural Science Foundation of China(No.82104760)Chinese Association of Chinese Medicine Youth Realistic Project(No.2022-QNQSDEP-09)+1 种基金Funding Project for Clinical Research Business Expenses at Central High-Level Hospitals(No.2022-NHLHCRF-LX-01-0308)the Second Group of the Elite Plan Backbone Talent Project at China-Japan Friendship Hospital(No.ZRJY2023-GG05)。
文摘Objective:To observe the clinical effect and safety of Lu'e Biyan Formula(LBF)combined with loratadine in the treatment of moderate to severe allergic rhinitis(AR)patients with Fei(Lung)-qi deficiencycoldness(FQDC)syndrome.Methods:From September 2023 to December 2024,moderate to severe AR patients with FQDC syndrome were recruited from the Outpatient Department of Integrated Traditional Chinese and Western Medicine for Pulmonary Diseases Part 1,China-Japan Friendship Hospital.Participants were randomly assigned to a test group and a control group by using a random number table at a ratio of 1:1.Both groups received oral loratadine tablets(10 mg,once daily)for 2 weeks.In addition,the test group received oral LBF(30 mL,twice daily),and the control group received a placebo of LBF.Changes in the Total Nasal Symptom Score(TNSS),Total Non-nasal Symptom Score(TNNSS),Visual Analog Scale(VAS),Rhinoconjunctivitis Quality of Life Questionnaire(RQLQ),and Chinese medicine(CM)syndrome scores before and after treatment were compared between groups.Moreover,the total effective rates and disease recurrence rates were compared.Adverse events(AEs)during the study period were also recorded.Results:Totally 109 participants were recruited,and the full analysis set included 105 cases,54 in the test group and 51 in the control group.Compared with the pre-treatment values,the scores of sneezing,runny nose,nasal obstruction,nasal itching,TNSS,TNNSS,VAS,RQLQ,and CM syndrome were significantly reduced in both groups at 1 and 2 weeks post-treatment and 12 weeks postdrug withdrawal(P<0.01).After treatment,the aforementioned scores in the test group were all markedly lower than those in the control group(P<0.01).Moreover,the total effective rate in the test group was higher than that in the control group(98.15%vs.70.59%,P<0.01).After 12 weeks of drug withdrawal,there was no significant difference in the recurrence rate between groups(13.21%vs.22.22%,P>0.05).No obvious AEs were observed in either group following treatment.Conclusions:The combination of LBF with loratadine can effectively alleviate the symptoms of moderate to severe AR patients with FQDC syndrome,thereby improving their quality of life.This therapy demonstrated both precise effect and high safety.(Trial registration No.ITMCTR2025000589)
基金Supported by the Eleventh Five-Year National Key Technology R&D Program(No.2007BAI20B092)
文摘To assess the efficacy and safety of Gastrosis No.1 compound in the treatment of functional dyspepsia with Spleen （Pi） and Stomach （Wei） deficiency-cold syndrome. Methods： A randomized, double-blind, placebo-controlled trial was performed in 5 centers. Patients with functional dyspepsia （FD） of Spleen-deficiency and qi-stagnation syndrome （162 cases） were randomly assigned to groups given Chinese herbal medicine （CHM） Gastrosis No.1 compound or placebo in a 2：1 ratio. This trial included a 4-week treatment period and a 4-week follow-up period. The outcomes were the dyspepsia symptom scores （measured by total dyspepsia symptom scale and single dyspepsia symptom scale） and syndromes of traditional Chinese medicine score （measured by traditional Chinese medicine syndrome scale）. The outcomes were noted at weeks 0, 4 and 8. Results： Compared with patients in the placebo group, patients in the CHM group showed significant improvement in the dyspepsia symptom scores as rated by patients and investigators （P〈0.01）, and also showed improvement in syndromes of traditional Chinese medicine score （P〈0.01）. No serious adverse event was reported. Safety tests obtained after 4 weeks of treatment showed no abnormal values. Conclusion： CHM Gastrosis No.1 compound was effective and safe in the treatment of functional dyspepsia with Spleen and Stomach deficiency-cold syndrome.
文摘Hot medicated cornpress treatment belongs to an external treatment and is a kindof moxibustion. ″Feng Qi Ai″ prescription was recorded in Yi Fang Lei Ju. Zhu Xu Men, Rui ZhuTang Fang. In the treatment, pain in the loin and the knees, cold-pain around the navel and in theabdornen,diarrhea due to deficiency and cold and other diseases are treated by combination of drugswith hot compress- We have irnproved the treatment and extended the range of its indication. It wasused for treatment 0f menorrhalgia due to cold uterine, gastralgia due to coId of rniddle-jiao, sciatica’periarthritis of shoulder, systremma,piriformis syndrome with good results.
文摘lasma cortisol levels and leukocyte glucocorticosteroid receptor (GCR) contents were assayed in 10 patients with Deficiency-Cold Syndrome, 10 patients with Deficiency-Heat Syndrome, and 10healthy subjects as normal control. The results showed practically normal plasma cortisol levels in the De-ticiency-Cold Group, but the leukocyte GCR contents were markedly lowered. In the Deficiency-Heatgroup, plasma cortisol levels were remarkably elevated and the leukocyte GCR contents also tended to behigher than normal. The quantity of plasma cortisol concentrations multiplied by leukocyte GCR contentscan be taken as a sensitive index for the differentiation of Cold and Heat natures in Deficiency Syndromes.
文摘In the treatment of 80 cases of the patients with deficient and cold pattern in the spleen and stomach by external application of herbal paste on the acupoints,the results showed remarkable effect in 52 cases,improvement in 24 cases,failure in 4 cases and the total effective rate in 95.0%.Remarkable therapeutic effects were achieved in three different diseases of same pattern.External application of herbal paste on the acupoints is definitely effective for stomachache in deficient and cold pattern of the spleen and stomach.
