Objective:To analyse the clinical effect of comprehensive rehabilitation therapy in patients with deep burns at different functional joint areas.Methods:Eighty-one patients with deep burns with different functional jo...Objective:To analyse the clinical effect of comprehensive rehabilitation therapy in patients with deep burns at different functional joint areas.Methods:Eighty-one patients with deep burns with different functional joint areas from April 2018 to April 2019 were divided into the conventional and rehabilitation groupings.The conventional group(n=40)received routine treatment and rehabilitation while the rehabilitation group(n=41)was given comprehensive rehabilitation treatment.Thereafter,the recovery of joint function in patients with deep burns in different areas,the combined value of clinical long-term treatment,the recovery of joint function and the score of daily living ability were calculated.Results:The total long-term effective rate of treatment,the recovery of the joint function,and the score of daily living ability of the patients with deep burns in the rehabilitation group were more favourable than those of the conventional group as demonstrated by P<0.05,the index data indicating statistical significance.Conclusion:Comprehensive rehabilitation therapy can reduce complications and improve the quality of life in patients with deep burns in different functional joint areas.展开更多
Objective: to explore and analyze the clinical effect and significance of deep wound repair in burn surgery. Methods: in this study, 60 burn patients treated in our hospital from February 2020 to February 2022 were se...Objective: to explore and analyze the clinical effect and significance of deep wound repair in burn surgery. Methods: in this study, 60 burn patients treated in our hospital from February 2020 to February 2022 were selected and randomly divided into experimental group and control group, with 30 patients in each group. 30 patients in the experimental group were treated by deep wound repair surgery, while 30 patients in the control group were treated by traditional treatment. The clinical treatment effect between the two groups was analyzed. Results: comparing the clinical treatment effect of two groups of patients, the number of planned reoperation wounds, the average number of operations, wound healing time and hospitalization time in the experimental group were significantly better than those in the control group. Comparing the relevant data between the two groups, the difference was significant (P 0.05), which was statistically significant. The skin flap healing and skin flap healing in the experimental group were also significantly better than those in the control group, and there was a significant difference between the two groups (P 0.05), which was statistically significant. Conclusion: by comparing the data of the two groups of patients, the recovery of the patients in the experimental group treated with deep burn surgery is obviously better than that of the patients in the control group treated with traditional methods. Therefore, the clinical treatment effect of deep burn surgery is ideal, and the wound healing speed of the treated patients is faster, so it is worthy of clinical promotion.展开更多
Skin is the largest body organ that is prone to the environment mostspecifically. Therefore the skin is susceptible to many damages, including burndamage. Burns can endanger life and are linked to high morbidity and m...Skin is the largest body organ that is prone to the environment mostspecifically. Therefore the skin is susceptible to many damages, including burndamage. Burns can endanger life and are linked to high morbidity and mortalityrates. Effective diagnosis with the help of accurate burn zone and wound depthevaluation is important for clinical efficacy. The following characteristics areassociated with the skin burn wound, such as healing, infection, painand stressand keloid formation. Tissue regeneration also takes a significant amount of timefor formation while considering skin healing after a burn injury. Deep neural networks can automatically assist in the extraction of features from a burn image. Inour approach to burn wound analysis and regeneration of the tissue of the skinburn wound, we use the Faster RCNN (Regional Convolutional Neural Network),which is based on their severity of the burn wound. The success rates of skin curefor burning injuries can be dramatically increased with the use of different skinreplacements. Our objective is to analyze different deep learning techniques thatmay help to analyze and classify burn wounds in a superficial, partial and complete thickness, while treating burn wounds more accurately. The application ofFaster RCNN effectively classifies wound without first degree, second and thirddegree confusion, thus providing a suitable solution to burning wounds. Theadvancement in the field of profound training offers an important path in the fieldof the processing and burning of trauma.展开更多
BACKGROUND Thermal injuries on free transferred or replanted tissues resulting from loss of sensibility are an infrequent occurrence.They require immediate and appropriate management before they progress to an irrever...BACKGROUND Thermal injuries on free transferred or replanted tissues resulting from loss of sensibility are an infrequent occurrence.They require immediate and appropriate management before they progress to an irreversible condition.Although negative pressure wound therapy(NPWT)can prevent wound progression by increasing microcirculation,the inappropriate application of NPWT on complicationthreatened transferred and replanted tissues can induce an adverse effect.CASE SUMMARY A 48-year-old woman who underwent immediate breast reconstruction with a deep inferior epigastric artery perforator free flap.While applying a heating pad directly to the flap site,she sustained a deep second to third-degree contact burn over 30%of the transferred flap on postoperative 7 d.As the necrotic changes had progressed,we applied an NPWT dressing over the burned area after en-bloc debridement of the transferred tissues on postoperative 21 d.After 4 d of NPWT application,the exposed fatty tissues of the flap changed to dry and browncolored necrotic tissues.Upon further debridement,we noted that the wound gradually reached total necrosis with a collapsed vascular pedicle of deep inferior epigastric artery.CONCLUSION Although NPWT has been shown to be successful for treating various wound types,the significant risk of NPWT application in short-lasting reconstructed flap wounds after thermal injury should be reminded.展开更多
The development of advanced wound healing materials for deep burn injuries remains a crucial challenge in biomedical fields.Here,we developed a multifunctional mineralized hydrogel dressing composed of sodium hyaluron...The development of advanced wound healing materials for deep burn injuries remains a crucial challenge in biomedical fields.Here,we developed a multifunctional mineralized hydrogel dressing composed of sodium hyaluronate(HA),Rhein,and Zn^(2+)(denoted as HRZn hydrogel)for enhanced deep burn wound healing.The HRZn hydrogel was readily prepared by directly mixing HA,Rhein,and Zn^(2+)and formed through a synergistic combination of in situ mineralization and dynamic crosslinking processes.Notably,we showed that Zn^(2+)could effectively induce the formation of Rhein nanofibers with the assistance of HA.This unique structure not only strengthened the hydrogel’s mechanical properties,but also endowed the HRZn hydrogel with sustained release ability towards Rhein and Zn^(2+).Leveraging the synergistic effects of Rhein and Zn^(2+),the HRZn hydrogel exhibited potent antimicrobial,anti-inflammatory,and pro-angiogenic properties.In vivo experiments demonstrated its efficacy in promoting the healing of Staphylococcus aureus(S.aureus)-infected deep burn wounds,highlighting its potential as an advanced wound dressing.Overall,this study presents a promising strategy for the development of multifunctional hydrogels tailored for the treatment of complex burn injuries.展开更多
Burn wounds result from exposure to hot liquids,chemicals,fire,electric discharge or radiation.Wound severity ranges from first-degree injury,which is superficial,to fourth-degree injury,which exposes bone,tendons and...Burn wounds result from exposure to hot liquids,chemicals,fire,electric discharge or radiation.Wound severity ranges from first-degree injury,which is superficial,to fourth-degree injury,which exposes bone,tendons and muscles.Rapid assessment of burn depth and accurate wound management in the outpatient setting is critical to prevent injury progression into deeper layers of the dermis.Injury progression is of particular pertinence to second-degree burns,which are the most common form of thermal burn.As our understanding of wound healing advances,treatment options and technologies for second-degree burn management also evolve.Polymeric hydrogels are a class of burn wound dressings that adhere to tissue,absorb wound exudate,protect from the environment,can be transparent facilitating serial wound evaluation and,in some cases,enable facile removal for dressing changes.This review briefly describes the burn level classification and common,commercially available dressings used to treat second-degree burns,and then focuses on new polymeric hydrogel burn dressings under preclinical development analyzing their design,structure and performance.The review presents the follow key learning points:(1)introduction to the integument system and the wound-healing process;(2)classification of burns according to severity and clinical appearance;(3)available dressings currently used for second-degree burns;(4)introduction to hydrogels and their preparation and characterization techniques;and(5)pre-clinical hydrogel burn wound dressings currently being developed.展开更多
文摘Objective:To analyse the clinical effect of comprehensive rehabilitation therapy in patients with deep burns at different functional joint areas.Methods:Eighty-one patients with deep burns with different functional joint areas from April 2018 to April 2019 were divided into the conventional and rehabilitation groupings.The conventional group(n=40)received routine treatment and rehabilitation while the rehabilitation group(n=41)was given comprehensive rehabilitation treatment.Thereafter,the recovery of joint function in patients with deep burns in different areas,the combined value of clinical long-term treatment,the recovery of joint function and the score of daily living ability were calculated.Results:The total long-term effective rate of treatment,the recovery of the joint function,and the score of daily living ability of the patients with deep burns in the rehabilitation group were more favourable than those of the conventional group as demonstrated by P<0.05,the index data indicating statistical significance.Conclusion:Comprehensive rehabilitation therapy can reduce complications and improve the quality of life in patients with deep burns in different functional joint areas.
文摘Objective: to explore and analyze the clinical effect and significance of deep wound repair in burn surgery. Methods: in this study, 60 burn patients treated in our hospital from February 2020 to February 2022 were selected and randomly divided into experimental group and control group, with 30 patients in each group. 30 patients in the experimental group were treated by deep wound repair surgery, while 30 patients in the control group were treated by traditional treatment. The clinical treatment effect between the two groups was analyzed. Results: comparing the clinical treatment effect of two groups of patients, the number of planned reoperation wounds, the average number of operations, wound healing time and hospitalization time in the experimental group were significantly better than those in the control group. Comparing the relevant data between the two groups, the difference was significant (P 0.05), which was statistically significant. The skin flap healing and skin flap healing in the experimental group were also significantly better than those in the control group, and there was a significant difference between the two groups (P 0.05), which was statistically significant. Conclusion: by comparing the data of the two groups of patients, the recovery of the patients in the experimental group treated with deep burn surgery is obviously better than that of the patients in the control group treated with traditional methods. Therefore, the clinical treatment effect of deep burn surgery is ideal, and the wound healing speed of the treated patients is faster, so it is worthy of clinical promotion.
文摘Skin is the largest body organ that is prone to the environment mostspecifically. Therefore the skin is susceptible to many damages, including burndamage. Burns can endanger life and are linked to high morbidity and mortalityrates. Effective diagnosis with the help of accurate burn zone and wound depthevaluation is important for clinical efficacy. The following characteristics areassociated with the skin burn wound, such as healing, infection, painand stressand keloid formation. Tissue regeneration also takes a significant amount of timefor formation while considering skin healing after a burn injury. Deep neural networks can automatically assist in the extraction of features from a burn image. Inour approach to burn wound analysis and regeneration of the tissue of the skinburn wound, we use the Faster RCNN (Regional Convolutional Neural Network),which is based on their severity of the burn wound. The success rates of skin curefor burning injuries can be dramatically increased with the use of different skinreplacements. Our objective is to analyze different deep learning techniques thatmay help to analyze and classify burn wounds in a superficial, partial and complete thickness, while treating burn wounds more accurately. The application ofFaster RCNN effectively classifies wound without first degree, second and thirddegree confusion, thus providing a suitable solution to burning wounds. Theadvancement in the field of profound training offers an important path in the fieldof the processing and burning of trauma.
文摘BACKGROUND Thermal injuries on free transferred or replanted tissues resulting from loss of sensibility are an infrequent occurrence.They require immediate and appropriate management before they progress to an irreversible condition.Although negative pressure wound therapy(NPWT)can prevent wound progression by increasing microcirculation,the inappropriate application of NPWT on complicationthreatened transferred and replanted tissues can induce an adverse effect.CASE SUMMARY A 48-year-old woman who underwent immediate breast reconstruction with a deep inferior epigastric artery perforator free flap.While applying a heating pad directly to the flap site,she sustained a deep second to third-degree contact burn over 30%of the transferred flap on postoperative 7 d.As the necrotic changes had progressed,we applied an NPWT dressing over the burned area after en-bloc debridement of the transferred tissues on postoperative 21 d.After 4 d of NPWT application,the exposed fatty tissues of the flap changed to dry and browncolored necrotic tissues.Upon further debridement,we noted that the wound gradually reached total necrosis with a collapsed vascular pedicle of deep inferior epigastric artery.CONCLUSION Although NPWT has been shown to be successful for treating various wound types,the significant risk of NPWT application in short-lasting reconstructed flap wounds after thermal injury should be reminded.
基金supported by the National Natural Science Foundation of China(Nos.52222307 and 52303214)the Department of Science and Technology of Jilin Province(No.20230204086YY).
文摘The development of advanced wound healing materials for deep burn injuries remains a crucial challenge in biomedical fields.Here,we developed a multifunctional mineralized hydrogel dressing composed of sodium hyaluronate(HA),Rhein,and Zn^(2+)(denoted as HRZn hydrogel)for enhanced deep burn wound healing.The HRZn hydrogel was readily prepared by directly mixing HA,Rhein,and Zn^(2+)and formed through a synergistic combination of in situ mineralization and dynamic crosslinking processes.Notably,we showed that Zn^(2+)could effectively induce the formation of Rhein nanofibers with the assistance of HA.This unique structure not only strengthened the hydrogel’s mechanical properties,but also endowed the HRZn hydrogel with sustained release ability towards Rhein and Zn^(2+).Leveraging the synergistic effects of Rhein and Zn^(2+),the HRZn hydrogel exhibited potent antimicrobial,anti-inflammatory,and pro-angiogenic properties.In vivo experiments demonstrated its efficacy in promoting the healing of Staphylococcus aureus(S.aureus)-infected deep burn wounds,highlighting its potential as an advanced wound dressing.Overall,this study presents a promising strategy for the development of multifunctional hydrogels tailored for the treatment of complex burn injuries.
基金the NIH(R01EB021308)Boston University for funding and supporting this research.
文摘Burn wounds result from exposure to hot liquids,chemicals,fire,electric discharge or radiation.Wound severity ranges from first-degree injury,which is superficial,to fourth-degree injury,which exposes bone,tendons and muscles.Rapid assessment of burn depth and accurate wound management in the outpatient setting is critical to prevent injury progression into deeper layers of the dermis.Injury progression is of particular pertinence to second-degree burns,which are the most common form of thermal burn.As our understanding of wound healing advances,treatment options and technologies for second-degree burn management also evolve.Polymeric hydrogels are a class of burn wound dressings that adhere to tissue,absorb wound exudate,protect from the environment,can be transparent facilitating serial wound evaluation and,in some cases,enable facile removal for dressing changes.This review briefly describes the burn level classification and common,commercially available dressings used to treat second-degree burns,and then focuses on new polymeric hydrogel burn dressings under preclinical development analyzing their design,structure and performance.The review presents the follow key learning points:(1)introduction to the integument system and the wound-healing process;(2)classification of burns according to severity and clinical appearance;(3)available dressings currently used for second-degree burns;(4)introduction to hydrogels and their preparation and characterization techniques;and(5)pre-clinical hydrogel burn wound dressings currently being developed.
