The development of advanced wound healing materials for deep burn injuries remains a crucial challenge in biomedical fields.Here,we developed a multifunctional mineralized hydrogel dressing composed of sodium hyaluron...The development of advanced wound healing materials for deep burn injuries remains a crucial challenge in biomedical fields.Here,we developed a multifunctional mineralized hydrogel dressing composed of sodium hyaluronate(HA),Rhein,and Zn^(2+)(denoted as HRZn hydrogel)for enhanced deep burn wound healing.The HRZn hydrogel was readily prepared by directly mixing HA,Rhein,and Zn^(2+)and formed through a synergistic combination of in situ mineralization and dynamic crosslinking processes.Notably,we showed that Zn^(2+)could effectively induce the formation of Rhein nanofibers with the assistance of HA.This unique structure not only strengthened the hydrogel’s mechanical properties,but also endowed the HRZn hydrogel with sustained release ability towards Rhein and Zn^(2+).Leveraging the synergistic effects of Rhein and Zn^(2+),the HRZn hydrogel exhibited potent antimicrobial,anti-inflammatory,and pro-angiogenic properties.In vivo experiments demonstrated its efficacy in promoting the healing of Staphylococcus aureus(S.aureus)-infected deep burn wounds,highlighting its potential as an advanced wound dressing.Overall,this study presents a promising strategy for the development of multifunctional hydrogels tailored for the treatment of complex burn injuries.展开更多
基金supported by the National Natural Science Foundation of China(Nos.52222307 and 52303214)the Department of Science and Technology of Jilin Province(No.20230204086YY).
文摘The development of advanced wound healing materials for deep burn injuries remains a crucial challenge in biomedical fields.Here,we developed a multifunctional mineralized hydrogel dressing composed of sodium hyaluronate(HA),Rhein,and Zn^(2+)(denoted as HRZn hydrogel)for enhanced deep burn wound healing.The HRZn hydrogel was readily prepared by directly mixing HA,Rhein,and Zn^(2+)and formed through a synergistic combination of in situ mineralization and dynamic crosslinking processes.Notably,we showed that Zn^(2+)could effectively induce the formation of Rhein nanofibers with the assistance of HA.This unique structure not only strengthened the hydrogel’s mechanical properties,but also endowed the HRZn hydrogel with sustained release ability towards Rhein and Zn^(2+).Leveraging the synergistic effects of Rhein and Zn^(2+),the HRZn hydrogel exhibited potent antimicrobial,anti-inflammatory,and pro-angiogenic properties.In vivo experiments demonstrated its efficacy in promoting the healing of Staphylococcus aureus(S.aureus)-infected deep burn wounds,highlighting its potential as an advanced wound dressing.Overall,this study presents a promising strategy for the development of multifunctional hydrogels tailored for the treatment of complex burn injuries.
