Federated learning(FL)activates distributed on-device computation techniques to model a better algorithm performance with the interaction of local model updates and global model distributions in aggregation averaging ...Federated learning(FL)activates distributed on-device computation techniques to model a better algorithm performance with the interaction of local model updates and global model distributions in aggregation averaging processes.However,in large-scale heterogeneous Internet of Things(IoT)cellular networks,massive multi-dimensional model update iterations and resource-constrained computation are challenging aspects to be tackled significantly.This paper introduces the system model of converging softwaredefined networking(SDN)and network functions virtualization(NFV)to enable device/resource abstractions and provide NFV-enabled edge FL(eFL)aggregation servers for advancing automation and controllability.Multi-agent deep Q-networks(MADQNs)target to enforce a self-learning softwarization,optimize resource allocation policies,and advocate computation offloading decisions.With gathered network conditions and resource states,the proposed agent aims to explore various actions for estimating expected longterm rewards in a particular state observation.In exploration phase,optimal actions for joint resource allocation and offloading decisions in different possible states are obtained by maximum Q-value selections.Action-based virtual network functions(VNF)forwarding graph(VNFFG)is orchestrated to map VNFs towards eFL aggregation server with sufficient communication and computation resources in NFV infrastructure(NFVI).The proposed scheme indicates deficient allocation actions,modifies the VNF backup instances,and reallocates the virtual resource for exploitation phase.Deep neural network(DNN)is used as a value function approximator,and epsilongreedy algorithm balances exploration and exploitation.The scheme primarily considers the criticalities of FL model services and congestion states to optimize long-term policy.Simulation results presented the outperformance of the proposed scheme over reference schemes in terms of Quality of Service(QoS)performance metrics,including packet drop ratio,packet drop counts,packet delivery ratio,delay,and throughput.展开更多
With the advent of Reinforcement Learning(RL)and its continuous progress,state-of-the-art RL systems have come up for many challenging and real-world tasks.Given the scope of this area,various techniques are found in ...With the advent of Reinforcement Learning(RL)and its continuous progress,state-of-the-art RL systems have come up for many challenging and real-world tasks.Given the scope of this area,various techniques are found in the literature.One such notable technique,Multiple Deep Q-Network(DQN)based RL systems use multiple DQN-based-entities,which learn together and communicate with each other.The learning has to be distributed wisely among all entities in such a scheme and the inter-entity communication protocol has to be carefully designed.As more complex DQNs come to the fore,the overall complexity of these multi-entity systems has increased many folds leading to issues like difficulty in training,need for high resources,more training time,and difficulty in fine-tuning leading to performance issues.Taking a cue from the parallel processing found in the nature and its efficacy,we propose a lightweight ensemble based approach for solving the core RL tasks.It uses multiple binary action DQNs having shared state and reward.The benefits of the proposed approach are overall simplicity,faster convergence and better performance compared to conventional DQN based approaches.The approach can potentially be extended to any type of DQN by forming its ensemble.Conducting extensive experimentation,promising results are obtained using the proposed ensemble approach on OpenAI Gym tasks,and Atari 2600 games as compared to recent techniques.The proposed approach gives a stateof-the-art score of 500 on the Cartpole-v1 task,259.2 on the LunarLander-v2 task,and state-of-the-art results on four out of five Atari 2600 games.展开更多
With the advancement of Vehicle-to-Everything(V2X)technology,efficient resource allocation in dynamic vehicular networks has become a critical challenge for achieving optimal performance.Existing methods suffer from h...With the advancement of Vehicle-to-Everything(V2X)technology,efficient resource allocation in dynamic vehicular networks has become a critical challenge for achieving optimal performance.Existing methods suffer from high computational complexity and decision latency under high-density traffic and heterogeneous network conditions.To address these challenges,this study presents an innovative framework that combines Graph Neural Networks(GNNs)with a Double Deep Q-Network(DDQN),utilizing dynamic graph structures and reinforcement learning.An adaptive neighbor sampling mechanism is introduced to dynamically select the most relevant neighbors based on interference levels and network topology,thereby improving decision accuracy and efficiency.Meanwhile,the framework models communication links as nodes and interference relationships as edges,effectively capturing the direct impact of interference on resource allocation while reducing computational complexity and preserving critical interaction information.Employing an aggregation mechanism based on the Graph Attention Network(GAT),it dynamically adjusts the neighbor sampling scope and performs attention-weighted aggregation based on node importance,ensuring more efficient and adaptive resource management.This design ensures reliable Vehicle-to-Vehicle(V2V)communication while maintaining high Vehicle-to-Infrastructure(V2I)throughput.The framework retains the global feature learning capabilities of GNNs and supports distributed network deployment,allowing vehicles to extract low-dimensional graph embeddings from local observations for real-time resource decisions.Experimental results demonstrate that the proposed method significantly reduces computational overhead,mitigates latency,and improves resource utilization efficiency in vehicular networks under complex traffic scenarios.This research not only provides a novel solution to resource allocation challenges in V2X networks but also advances the application of DDQN in intelligent transportation systems,offering substantial theoretical significance and practical value.展开更多
At present,energy consumption is one of the main bottlenecks in autonomous mobile robot development.To address the challenge of high energy consumption in path planning for autonomous mobile robots navigating unknown ...At present,energy consumption is one of the main bottlenecks in autonomous mobile robot development.To address the challenge of high energy consumption in path planning for autonomous mobile robots navigating unknown and complex environments,this paper proposes an Attention-Enhanced Dueling Deep Q-Network(ADDueling DQN),which integrates a multi-head attention mechanism and a prioritized experience replay strategy into a Dueling-DQN reinforcement learning framework.A multi-objective reward function,centered on energy efficiency,is designed to comprehensively consider path length,terrain slope,motion smoothness,and obstacle avoidance,enabling optimal low-energy trajectory generation in 3D space from the source.The incorporation of a multihead attention mechanism allows the model to dynamically focus on energy-critical state features—such as slope gradients and obstacle density—thereby significantly improving its ability to recognize and avoid energy-intensive paths.Additionally,the prioritized experience replay mechanism accelerates learning from key decision-making experiences,suppressing inefficient exploration and guiding the policy toward low-energy solutions more rapidly.The effectiveness of the proposed path planning algorithm is validated through simulation experiments conducted in multiple off-road scenarios.Results demonstrate that AD-Dueling DQN consistently achieves the lowest average energy consumption across all tested environments.Moreover,the proposed method exhibits faster convergence and greater training stability compared to baseline algorithms,highlighting its global optimization capability under energy-aware objectives in complex terrains.This study offers an efficient and scalable intelligent control strategy for the development of energy-conscious autonomous navigation systems.展开更多
The rudder mechanism of the X-rudder autonomous underwater cehicle(AUV)is relatively complex,and fault diagnosis capability is an important guarantee for its task execution in complex underwater environments.However,t...The rudder mechanism of the X-rudder autonomous underwater cehicle(AUV)is relatively complex,and fault diagnosis capability is an important guarantee for its task execution in complex underwater environments.However,traditional fault diagnosis methods currently rely on prior knowledge and expert experience,and lack accuracy.In order to improve the autonomy and accuracy of fault diagnosis methods,and overcome the shortcomings of traditional algorithms,this paper proposes an X-steering AUV fault diagnosis model based on the deep reinforcement learning deep Q network(DQN)algorithm,which can learn the relationship between state data and fault types,map raw residual data to corresponding fault patterns,and achieve end-to-end mapping.In addition,to solve the problem of few X-steering fault sample data,Dropout technology is introduced during the model training phase to improve the performance of the DQN algorithm.Experimental results show that the proposed model has improved the convergence speed and comprehensive performance indicators compared to the unimproved DQN algorithm,with precision,recall,F_(1-score),and accuracy reaching up to 100%,98.07%,99.02%,and 98.50% respectively,and the model’s accuracy is higher than other machine learning algorithms like back propagation,support vector machine.展开更多
The increased interest in geothermal energy is evident,along with the exploitation of traditional hydrothermal systems,in the growing research and projects developing around the reuse of already-drilled oil,gas,and ex...The increased interest in geothermal energy is evident,along with the exploitation of traditional hydrothermal systems,in the growing research and projects developing around the reuse of already-drilled oil,gas,and exploration wells.The Republic of Croatia has around 4000 wells,however,due to a long period since most of these wells were drilled and completed,there is uncertainty about how many are available for retrofitting as deep-borehole heat exchangers.Nevertheless,as hydrocarbon production decreases,it is expected that the number of wells available for the revitalization and exploitation of geothermal energy will increase.The revitalization of wells via deep-borehole heat exchangers involves installing a coaxial heat exchanger and circulating the working fluid in a closed system,during which heat is transferred from the surrounding rock medium to the circulating fluid.Since drilled wells are not of uniformdepth and are located in areas with different thermal rock properties and geothermal gradients,an analysis was conducted to determine available thermal energy as a function of well depth,geothermal gradient,and circulating fluid flow rate.Additionally,an economic analysis was performed to determine the benefits of retrofitting existing assets,such as drilled wells,compared to drilling new wells to obtain the same amount of thermal energy.展开更多
Wearable sensors integrated with deep learning techniques have the potential to revolutionize seamless human-machine interfaces for real-time health monitoring,clinical diagnosis,and robotic applications.Nevertheless,...Wearable sensors integrated with deep learning techniques have the potential to revolutionize seamless human-machine interfaces for real-time health monitoring,clinical diagnosis,and robotic applications.Nevertheless,it remains a critical challenge to simultaneously achieve desirable mechanical and electrical performance along with biocompatibility,adhesion,self-healing,and environmental robustness with excellent sensing metrics.Herein,we report a multifunctional,anti-freezing,selfadhesive,and self-healable organogel pressure sensor composed of cobalt nanoparticle encapsulated nitrogen-doped carbon nanotubes(CoN CNT)embedded in a polyvinyl alcohol-gelatin(PVA/GLE)matrix.Fabricated using a binary solvent system of water and ethylene glycol(EG),the CoN CNT/PVA/GLE organogel exhibits excellent flexibility,biocompatibility,and temperature tolerance with remarkable environmental stability.Electrochemical impedance spectroscopy confirms near-stable performance across a broad humidity range(40%-95%RH).Freeze-tolerant conductivity under sub-zero conditions(-20℃)is attributed to the synergistic role of CoN CNT and EG,preserving mobility and network integrity.The Co N CNT/PVA/GLE organogel sensor exhibits high sensitivity of 5.75 k Pa^(-1)in the detection range from 0 to 20 k Pa,ideal for subtle biomechanical motion detection.A smart human-machine interface for English letter recognition using deep learning achieved 98%accuracy.The organogel sensor utility was extended to detect human gestures like finger bending,wrist motion,and throat vibration during speech.展开更多
Nondestructive measurement technology of phenotype can provide substantial phenotypic data support for applications such as seedling breeding,management,and quality testing.The current method of measuring seedling phe...Nondestructive measurement technology of phenotype can provide substantial phenotypic data support for applications such as seedling breeding,management,and quality testing.The current method of measuring seedling phenotypes mainly relies on manual measurement which is inefficient,subjective and destroys samples.Therefore,the paper proposes a nondestructive measurement method for the canopy phenotype of the watermelon plug seedlings based on deep learning.The Azure Kinect was used to shoot canopy color images,depth images,and RGB-D images of the watermelon plug seedlings.The Mask-RCNN network was used to classify,segment,and count the canopy leaves of the watermelon plug seedlings.To reduce the error of leaf area measurement caused by mutual occlusion of leaves,the leaves were repaired by CycleGAN,and the depth images were restored by image processing.Then,the Delaunay triangulation was adopted to measure the leaf area in the leaf point cloud.The YOLOX target detection network was used to identify the growing point position of each seedling on the plug tray.Then the depth differences between the growing point and the upper surface of the plug tray were calculated to obtain plant height.The experiment results show that the nondestructive measurement algorithm proposed in this paper achieves good measurement performance for the watermelon plug seedlings from the 1 true-leaf to 3 true-leaf stages.The average relative error of measurement is 2.33%for the number of true leaves,4.59%for the number of cotyledons,8.37%for the leaf area,and 3.27%for the plant height.The experiment results demonstrate that the proposed algorithm in this paper provides an effective solution for the nondestructive measurement of the canopy phenotype of the plug seedlings.展开更多
Effective partitioning is crucial for enabling parallel restoration of power systems after blackouts.This paper proposes a novel partitioning method based on deep reinforcement learning.First,the partitioning decision...Effective partitioning is crucial for enabling parallel restoration of power systems after blackouts.This paper proposes a novel partitioning method based on deep reinforcement learning.First,the partitioning decision process is formulated as a Markov decision process(MDP)model to maximize the modularity.Corresponding key partitioning constraints on parallel restoration are considered.Second,based on the partitioning objective and constraints,the reward function of the partitioning MDP model is set by adopting a relative deviation normalization scheme to reduce mutual interference between the reward and penalty in the reward function.The soft bonus scaling mechanism is introduced to mitigate overestimation caused by abrupt jumps in the reward.Then,the deep Q network method is applied to solve the partitioning MDP model and generate partitioning schemes.Two experience replay buffers are employed to speed up the training process of the method.Finally,case studies on the IEEE 39-bus test system demonstrate that the proposed method can generate a high-modularity partitioning result that meets all key partitioning constraints,thereby improving the parallelism and reliability of the restoration process.Moreover,simulation results demonstrate that an appropriate discount factor is crucial for ensuring both the convergence speed and the stability of the partitioning training.展开更多
This systematic review aims to comprehensively examine and compare deep learning methods for brain tumor segmentation and classification using MRI and other imaging modalities,focusing on recent trends from 2022 to 20...This systematic review aims to comprehensively examine and compare deep learning methods for brain tumor segmentation and classification using MRI and other imaging modalities,focusing on recent trends from 2022 to 2025.The primary objective is to evaluate methodological advancements,model performance,dataset usage,and existing challenges in developing clinically robust AI systems.We included peer-reviewed journal articles and highimpact conference papers published between 2022 and 2025,written in English,that proposed or evaluated deep learning methods for brain tumor segmentation and/or classification.Excluded were non-open-access publications,books,and non-English articles.A structured search was conducted across Scopus,Google Scholar,Wiley,and Taylor&Francis,with the last search performed in August 2025.Risk of bias was not formally quantified but considered during full-text screening based on dataset diversity,validation methods,and availability of performance metrics.We used narrative synthesis and tabular benchmarking to compare performance metrics(e.g.,accuracy,Dice score)across model types(CNN,Transformer,Hybrid),imaging modalities,and datasets.A total of 49 studies were included(43 journal articles and 6 conference papers).These studies spanned over 9 public datasets(e.g.,BraTS,Figshare,REMBRANDT,MOLAB)and utilized a range of imaging modalities,predominantly MRI.Hybrid models,especially ResViT and UNetFormer,consistently achieved high performance,with classification accuracy exceeding 98%and segmentation Dice scores above 0.90 across multiple studies.Transformers and hybrid architectures showed increasing adoption post2023.Many studies lacked external validation and were evaluated only on a few benchmark datasets,raising concerns about generalizability and dataset bias.Few studies addressed clinical interpretability or uncertainty quantification.Despite promising results,particularly for hybrid deep learning models,widespread clinical adoption remains limited due to lack of validation,interpretability concerns,and real-world deployment barriers.展开更多
Underwater pipeline inspection plays a vital role in the proactive maintenance and management of critical marine infrastructure and subaquatic systems.However,the inspection of underwater pipelines presents a challeng...Underwater pipeline inspection plays a vital role in the proactive maintenance and management of critical marine infrastructure and subaquatic systems.However,the inspection of underwater pipelines presents a challenge due to factors such as light scattering,absorption,restricted visibility,and ambient noise.The advancement of deep learning has introduced powerful techniques for processing large amounts of unstructured and imperfect data collected from underwater environments.This study evaluated the efficacy of the You Only Look Once(YOLO)algorithm,a real-time object detection and localization model based on convolutional neural networks,in identifying and classifying various types of pipeline defects in underwater settings.YOLOv8,the latest evolution in the YOLO family,integrates advanced capabilities,such as anchor-free detection,a cross-stage partial network backbone for efficient feature extraction,and a feature pyramid network+path aggregation network neck for robust multi-scale object detection,which make it particularly well-suited for complex underwater environments.Due to the lack of suitable open-access datasets for underwater pipeline defects,a custom dataset was captured using a remotely operated vehicle in a controlled environment.This application has the following assets available for use.Extensive experimentation demonstrated that YOLOv8 X-Large consistently outperformed other models in terms of pipe defect detection and classification and achieved a strong balance between precision and recall in identifying pipeline cracks,rust,corners,defective welds,flanges,tapes,and holes.This research establishes the baseline performance of YOLOv8 for underwater defect detection and showcases its potential to enhance the reliability and efficiency of pipeline inspection tasks in challenging underwater environments.展开更多
Deep learning-based methods have become alternatives to traditional numerical weather prediction systems,offering faster computation and the ability to utilize large historical datasets.However,the application of deep...Deep learning-based methods have become alternatives to traditional numerical weather prediction systems,offering faster computation and the ability to utilize large historical datasets.However,the application of deep learning to medium-range regional weather forecasting with limited data remains a significant challenge.In this work,three key solutions are proposed:(1)motivated by the need to improve model performance in data-scarce regional forecasting scenarios,the authors innovatively apply semantic segmentation models,to better capture spatiotemporal features and improve prediction accuracy;(2)recognizing the challenge of overfitting and the inability of traditional noise-based data augmentation methods to effectively enhance model robustness,a novel learnable Gaussian noise mechanism is introduced that allows the model to adaptively optimize perturbations for different locations,ensuring more effective learning;and(3)to address the issue of error accumulation in autoregressive prediction,as well as the challenge of learning difficulty and the lack of intermediate data utilization in one-shot prediction,the authors propose a cascade prediction approach that effectively resolves these problems while significantly improving model forecasting performance.The method achieves a competitive result in The East China Regional AI Medium Range Weather Forecasting Competition.Ablation experiments further validate the effectiveness of each component,highlighting their contributions to enhancing prediction performance.展开更多
With the growing advancement of wireless communication technologies,WiFi-based human sensing has gained increasing attention as a non-intrusive and device-free solution.Among the available signal types,Channel State I...With the growing advancement of wireless communication technologies,WiFi-based human sensing has gained increasing attention as a non-intrusive and device-free solution.Among the available signal types,Channel State Information(CSI)offers fine-grained temporal,frequency,and spatial insights into multipath propagation,making it a crucial data source for human-centric sensing.Recently,the integration of deep learning has significantly improved the robustness and automation of feature extraction from CSI in complex environments.This paper provides a comprehensive review of deep learning-enhanced human sensing based on CSI.We first outline mainstream CSI acquisition tools and their hardware specifications,then provide a detailed discussion of preprocessing methods such as denoising,time–frequency transformation,data segmentation,and augmentation.Subsequently,we categorize deep learning approaches according to sensing tasks—namely detection,localization,and recognition—and highlight representative models across application scenarios.Finally,we examine key challenges including domain generalization,multi-user interference,and limited data availability,and we propose future research directions involving lightweight model deployment,multimodal data fusion,and semantic-level sensing.展开更多
Honeycombing Lung(HCL)is a chronic lung condition marked by advanced fibrosis,resulting in enlarged air spaces with thick fibrotic walls,which are visible on Computed Tomography(CT)scans.Differentiating between normal...Honeycombing Lung(HCL)is a chronic lung condition marked by advanced fibrosis,resulting in enlarged air spaces with thick fibrotic walls,which are visible on Computed Tomography(CT)scans.Differentiating between normal lung tissue,honeycombing lungs,and Ground Glass Opacity(GGO)in CT images is often challenging for radiologists and may lead to misinterpretations.Although earlier studies have proposed models to detect and classify HCL,many faced limitations such as high computational demands,lower accuracy,and difficulty distinguishing between HCL and GGO.CT images are highly effective for lung classification due to their high resolution,3D visualization,and sensitivity to tissue density variations.This study introduces Honeycombing Lungs Network(HCL Net),a novel classification algorithm inspired by ResNet50V2 and enhanced to overcome the shortcomings of previous approaches.HCL Net incorporates additional residual blocks,refined preprocessing techniques,and selective parameter tuning to improve classification performance.The dataset,sourced from the University Malaya Medical Centre(UMMC)and verified by expert radiologists,consists of CT images of normal,honeycombing,and GGO lungs.Experimental evaluations across five assessments demonstrated that HCL Net achieved an outstanding classification accuracy of approximately 99.97%.It also recorded strong performance in other metrics,achieving 93%precision,100%sensitivity,89%specificity,and an AUC-ROC score of 97%.Comparative analysis with baseline feature engineering methods confirmed the superior efficacy of HCL Net.The model significantly reduces misclassification,particularly between honeycombing and GGO lungs,enhancing diagnostic precision and reliability in lung image analysis.展开更多
Vehicle Edge Computing(VEC)and Cloud Computing(CC)significantly enhance the processing efficiency of delay-sensitive and computation-intensive applications by offloading compute-intensive tasks from resource-constrain...Vehicle Edge Computing(VEC)and Cloud Computing(CC)significantly enhance the processing efficiency of delay-sensitive and computation-intensive applications by offloading compute-intensive tasks from resource-constrained onboard devices to nearby Roadside Unit(RSU),thereby achieving lower delay and energy consumption.However,due to the limited storage capacity and energy budget of RSUs,it is challenging to meet the demands of the highly dynamic Internet of Vehicles(IoV)environment.Therefore,determining reasonable service caching and computation offloading strategies is crucial.To address this,this paper proposes a joint service caching scheme for cloud-edge collaborative IoV computation offloading.By modeling the dynamic optimization problem using Markov Decision Processes(MDP),the scheme jointly optimizes task delay,energy consumption,load balancing,and privacy entropy to achieve better quality of service.Additionally,a dynamic adaptive multi-objective deep reinforcement learning algorithm is proposed.Each Double Deep Q-Network(DDQN)agent obtains rewards for different objectives based on distinct reward functions and dynamically updates the objective weights by learning the value changes between objectives using Radial Basis Function Networks(RBFN),thereby efficiently approximating the Pareto-optimal decisions for multiple objectives.Extensive experiments demonstrate that the proposed algorithm can better coordinate the three-tier computing resources of cloud,edge,and vehicles.Compared to existing algorithms,the proposed method reduces task delay and energy consumption by 10.64%and 5.1%,respectively.展开更多
An image processing and deep learning method for identifying different types of rock images was proposed.Preprocessing,such as rock image acquisition,gray scaling,Gaussian blurring,and feature dimensionality reduction...An image processing and deep learning method for identifying different types of rock images was proposed.Preprocessing,such as rock image acquisition,gray scaling,Gaussian blurring,and feature dimensionality reduction,was conducted to extract useful feature information and recognize and classify rock images using Tensor Flow-based convolutional neural network(CNN)and Py Qt5.A rock image dataset was established and separated into workouts,confirmation sets,and test sets.The framework was subsequently compiled and trained.The categorization approach was evaluated using image data from the validation and test datasets,and key metrics,such as accuracy,precision,and recall,were analyzed.Finally,the classification model conducted a probabilistic analysis of the measured data to determine the equivalent lithological type for each image.The experimental results indicated that the method combining deep learning,Tensor Flow-based CNN,and Py Qt5 to recognize and classify rock images has an accuracy rate of up to 98.8%,and can be successfully utilized for rock image recognition.The system can be extended to geological exploration,mine engineering,and other rock and mineral resource development to more efficiently and accurately recognize rock samples.Moreover,it can match them with the intelligent support design system to effectively improve the reliability and economy of the support scheme.The system can serve as a reference for supporting the design of other mining and underground space projects.展开更多
The rapid growth of biomedical data,particularly multi-omics data including genomes,transcriptomics,proteomics,metabolomics,and epigenomics,medical research and clinical decision-making confront both new opportunities...The rapid growth of biomedical data,particularly multi-omics data including genomes,transcriptomics,proteomics,metabolomics,and epigenomics,medical research and clinical decision-making confront both new opportunities and obstacles.The huge and diversified nature of these datasets cannot always be managed using traditional data analysis methods.As a consequence,deep learning has emerged as a strong tool for analysing numerous omics data due to its ability to handle complex and non-linear relationships.This paper explores the fundamental concepts of deep learning and how they are used in multi-omics medical data mining.We demonstrate how autoencoders,variational autoencoders,multimodal models,attention mechanisms,transformers,and graph neural networks enable pattern analysis and recognition across all omics data.Deep learning has been found to be effective in illness classification,biomarker identification,gene network learning,and therapeutic efficacy prediction.We also consider critical problems like as data quality,model explainability,whether findings can be repeated,and computational power requirements.We now consider future elements of combining omics with clinical and imaging data,explainable AI,federated learning,and real-time diagnostics.Overall,this study emphasises the need of collaborating across disciplines to advance deep learning-based multi-omics research for precision medicine and comprehending complicated disorders.展开更多
Alzheimer's disease is the most common type of cognitive disorder,and there is an urgent need to develop more effective,targeted and safer therapies for patients with this condition.Deep brain stimulation is an in...Alzheimer's disease is the most common type of cognitive disorder,and there is an urgent need to develop more effective,targeted and safer therapies for patients with this condition.Deep brain stimulation is an invasive surgical treatment that modulates abnormal neural activity by implanting electrodes into specific brain areas followed by electrical stimulation.As an emerging therapeutic approach,deep brain stimulation shows significant promise as a potential new therapy for Alzheimer's disease.Here,we review the potential mechanisms and therapeutic effects of deep brain stimulation in the treatment of Alzheimer's disease based on existing clinical and basic research.In clinical studies,the most commonly targeted sites include the fornix,the nucleus basalis of Meynert,and the ventral capsule/ventral striatum.Basic research has found that the most frequently targeted areas include the fornix,nucleus basalis of Meynert,hippocampus,entorhinal cortex,and rostral intralaminar thalamic nucleus.All of these individual targets exhibit therapeutic potential for patients with Alzheimer's disease and associated mechanisms of action have been investigated.Deep brain stimulation may exert therapeutic effects on Alzheimer's disease through various mechanisms,including reducing the deposition of amyloid-β,activation of the cholinergic system,increasing the levels of neurotrophic factors,enhancing synaptic activity and plasticity,promoting neurogenesis,and improving glucose metabolism.Currently,clinical trials investigating deep brain stimulation for Alzheimer's disease remain insufficient.In the future,it is essential to focus on translating preclinical mechanisms into clinical trials.Furthermore,consecutive follow-up studies are needed to evaluate the long-term safety and efficacy of deep brain stimulation for Alzheimer's disease,including cognitive function,neuropsychiatric symptoms,quality of life and changes in Alzheimer's disease biomarkers.Researchers must also prioritize the initiation of multi-center clinical trials of deep brain stimulation with large sample sizes and target earlier therapeutic windows,such as the prodromal and even the preclinical stages of Alzheimer's disease.Adopting these approaches will permit the efficient exploration of more effective and safer deep brain stimulation therapies for patients with Alzheimer's disease.展开更多
基金This work was funded by BK21 FOUR(Fostering Outstanding Universities for Research)(No.5199990914048)this research was supported by Basic Science Research Program through the National Research Foundation of Korea(NRF)funded by the Ministry of Education(NRF-2020R1I1A3066543)In addition,this work was supported by the Soonchunhyang University Research Fund.
文摘Federated learning(FL)activates distributed on-device computation techniques to model a better algorithm performance with the interaction of local model updates and global model distributions in aggregation averaging processes.However,in large-scale heterogeneous Internet of Things(IoT)cellular networks,massive multi-dimensional model update iterations and resource-constrained computation are challenging aspects to be tackled significantly.This paper introduces the system model of converging softwaredefined networking(SDN)and network functions virtualization(NFV)to enable device/resource abstractions and provide NFV-enabled edge FL(eFL)aggregation servers for advancing automation and controllability.Multi-agent deep Q-networks(MADQNs)target to enforce a self-learning softwarization,optimize resource allocation policies,and advocate computation offloading decisions.With gathered network conditions and resource states,the proposed agent aims to explore various actions for estimating expected longterm rewards in a particular state observation.In exploration phase,optimal actions for joint resource allocation and offloading decisions in different possible states are obtained by maximum Q-value selections.Action-based virtual network functions(VNF)forwarding graph(VNFFG)is orchestrated to map VNFs towards eFL aggregation server with sufficient communication and computation resources in NFV infrastructure(NFVI).The proposed scheme indicates deficient allocation actions,modifies the VNF backup instances,and reallocates the virtual resource for exploitation phase.Deep neural network(DNN)is used as a value function approximator,and epsilongreedy algorithm balances exploration and exploitation.The scheme primarily considers the criticalities of FL model services and congestion states to optimize long-term policy.Simulation results presented the outperformance of the proposed scheme over reference schemes in terms of Quality of Service(QoS)performance metrics,including packet drop ratio,packet drop counts,packet delivery ratio,delay,and throughput.
文摘With the advent of Reinforcement Learning(RL)and its continuous progress,state-of-the-art RL systems have come up for many challenging and real-world tasks.Given the scope of this area,various techniques are found in the literature.One such notable technique,Multiple Deep Q-Network(DQN)based RL systems use multiple DQN-based-entities,which learn together and communicate with each other.The learning has to be distributed wisely among all entities in such a scheme and the inter-entity communication protocol has to be carefully designed.As more complex DQNs come to the fore,the overall complexity of these multi-entity systems has increased many folds leading to issues like difficulty in training,need for high resources,more training time,and difficulty in fine-tuning leading to performance issues.Taking a cue from the parallel processing found in the nature and its efficacy,we propose a lightweight ensemble based approach for solving the core RL tasks.It uses multiple binary action DQNs having shared state and reward.The benefits of the proposed approach are overall simplicity,faster convergence and better performance compared to conventional DQN based approaches.The approach can potentially be extended to any type of DQN by forming its ensemble.Conducting extensive experimentation,promising results are obtained using the proposed ensemble approach on OpenAI Gym tasks,and Atari 2600 games as compared to recent techniques.The proposed approach gives a stateof-the-art score of 500 on the Cartpole-v1 task,259.2 on the LunarLander-v2 task,and state-of-the-art results on four out of five Atari 2600 games.
基金Project ZR2023MF111 supported by Shandong Provincial Natural Science Foundation。
文摘With the advancement of Vehicle-to-Everything(V2X)technology,efficient resource allocation in dynamic vehicular networks has become a critical challenge for achieving optimal performance.Existing methods suffer from high computational complexity and decision latency under high-density traffic and heterogeneous network conditions.To address these challenges,this study presents an innovative framework that combines Graph Neural Networks(GNNs)with a Double Deep Q-Network(DDQN),utilizing dynamic graph structures and reinforcement learning.An adaptive neighbor sampling mechanism is introduced to dynamically select the most relevant neighbors based on interference levels and network topology,thereby improving decision accuracy and efficiency.Meanwhile,the framework models communication links as nodes and interference relationships as edges,effectively capturing the direct impact of interference on resource allocation while reducing computational complexity and preserving critical interaction information.Employing an aggregation mechanism based on the Graph Attention Network(GAT),it dynamically adjusts the neighbor sampling scope and performs attention-weighted aggregation based on node importance,ensuring more efficient and adaptive resource management.This design ensures reliable Vehicle-to-Vehicle(V2V)communication while maintaining high Vehicle-to-Infrastructure(V2I)throughput.The framework retains the global feature learning capabilities of GNNs and supports distributed network deployment,allowing vehicles to extract low-dimensional graph embeddings from local observations for real-time resource decisions.Experimental results demonstrate that the proposed method significantly reduces computational overhead,mitigates latency,and improves resource utilization efficiency in vehicular networks under complex traffic scenarios.This research not only provides a novel solution to resource allocation challenges in V2X networks but also advances the application of DDQN in intelligent transportation systems,offering substantial theoretical significance and practical value.
文摘At present,energy consumption is one of the main bottlenecks in autonomous mobile robot development.To address the challenge of high energy consumption in path planning for autonomous mobile robots navigating unknown and complex environments,this paper proposes an Attention-Enhanced Dueling Deep Q-Network(ADDueling DQN),which integrates a multi-head attention mechanism and a prioritized experience replay strategy into a Dueling-DQN reinforcement learning framework.A multi-objective reward function,centered on energy efficiency,is designed to comprehensively consider path length,terrain slope,motion smoothness,and obstacle avoidance,enabling optimal low-energy trajectory generation in 3D space from the source.The incorporation of a multihead attention mechanism allows the model to dynamically focus on energy-critical state features—such as slope gradients and obstacle density—thereby significantly improving its ability to recognize and avoid energy-intensive paths.Additionally,the prioritized experience replay mechanism accelerates learning from key decision-making experiences,suppressing inefficient exploration and guiding the policy toward low-energy solutions more rapidly.The effectiveness of the proposed path planning algorithm is validated through simulation experiments conducted in multiple off-road scenarios.Results demonstrate that AD-Dueling DQN consistently achieves the lowest average energy consumption across all tested environments.Moreover,the proposed method exhibits faster convergence and greater training stability compared to baseline algorithms,highlighting its global optimization capability under energy-aware objectives in complex terrains.This study offers an efficient and scalable intelligent control strategy for the development of energy-conscious autonomous navigation systems.
基金Supported by the National Natural Science Foundation of China under Grant Nos.52071099,52071104National Key Project of Research and Development Program under Grant No.2021YFC2801300Research Fund from National Key Laboratory of Autonomous Marine Vehicle Technology under Grant No.2023-SXJQR-SYSJJ01.
文摘The rudder mechanism of the X-rudder autonomous underwater cehicle(AUV)is relatively complex,and fault diagnosis capability is an important guarantee for its task execution in complex underwater environments.However,traditional fault diagnosis methods currently rely on prior knowledge and expert experience,and lack accuracy.In order to improve the autonomy and accuracy of fault diagnosis methods,and overcome the shortcomings of traditional algorithms,this paper proposes an X-steering AUV fault diagnosis model based on the deep reinforcement learning deep Q network(DQN)algorithm,which can learn the relationship between state data and fault types,map raw residual data to corresponding fault patterns,and achieve end-to-end mapping.In addition,to solve the problem of few X-steering fault sample data,Dropout technology is introduced during the model training phase to improve the performance of the DQN algorithm.Experimental results show that the proposed model has improved the convergence speed and comprehensive performance indicators compared to the unimproved DQN algorithm,with precision,recall,F_(1-score),and accuracy reaching up to 100%,98.07%,99.02%,and 98.50% respectively,and the model’s accuracy is higher than other machine learning algorithms like back propagation,support vector machine.
文摘The increased interest in geothermal energy is evident,along with the exploitation of traditional hydrothermal systems,in the growing research and projects developing around the reuse of already-drilled oil,gas,and exploration wells.The Republic of Croatia has around 4000 wells,however,due to a long period since most of these wells were drilled and completed,there is uncertainty about how many are available for retrofitting as deep-borehole heat exchangers.Nevertheless,as hydrocarbon production decreases,it is expected that the number of wells available for the revitalization and exploitation of geothermal energy will increase.The revitalization of wells via deep-borehole heat exchangers involves installing a coaxial heat exchanger and circulating the working fluid in a closed system,during which heat is transferred from the surrounding rock medium to the circulating fluid.Since drilled wells are not of uniformdepth and are located in areas with different thermal rock properties and geothermal gradients,an analysis was conducted to determine available thermal energy as a function of well depth,geothermal gradient,and circulating fluid flow rate.Additionally,an economic analysis was performed to determine the benefits of retrofitting existing assets,such as drilled wells,compared to drilling new wells to obtain the same amount of thermal energy.
基金supported by the Basic Science Research Program(2023R1A2C3004336,RS-202300243807)&Regional Leading Research Center(RS-202400405278)through the National Research Foundation of Korea(NRF)grant funded by the Korea Government(MSIT)。
文摘Wearable sensors integrated with deep learning techniques have the potential to revolutionize seamless human-machine interfaces for real-time health monitoring,clinical diagnosis,and robotic applications.Nevertheless,it remains a critical challenge to simultaneously achieve desirable mechanical and electrical performance along with biocompatibility,adhesion,self-healing,and environmental robustness with excellent sensing metrics.Herein,we report a multifunctional,anti-freezing,selfadhesive,and self-healable organogel pressure sensor composed of cobalt nanoparticle encapsulated nitrogen-doped carbon nanotubes(CoN CNT)embedded in a polyvinyl alcohol-gelatin(PVA/GLE)matrix.Fabricated using a binary solvent system of water and ethylene glycol(EG),the CoN CNT/PVA/GLE organogel exhibits excellent flexibility,biocompatibility,and temperature tolerance with remarkable environmental stability.Electrochemical impedance spectroscopy confirms near-stable performance across a broad humidity range(40%-95%RH).Freeze-tolerant conductivity under sub-zero conditions(-20℃)is attributed to the synergistic role of CoN CNT and EG,preserving mobility and network integrity.The Co N CNT/PVA/GLE organogel sensor exhibits high sensitivity of 5.75 k Pa^(-1)in the detection range from 0 to 20 k Pa,ideal for subtle biomechanical motion detection.A smart human-machine interface for English letter recognition using deep learning achieved 98%accuracy.The organogel sensor utility was extended to detect human gestures like finger bending,wrist motion,and throat vibration during speech.
基金funded by the National Key Research and Development Program of China(Grant No.2019YFD1001900)the HZAU-AGIS Cooperation Fund(Grant No.SZYJY2022006).
文摘Nondestructive measurement technology of phenotype can provide substantial phenotypic data support for applications such as seedling breeding,management,and quality testing.The current method of measuring seedling phenotypes mainly relies on manual measurement which is inefficient,subjective and destroys samples.Therefore,the paper proposes a nondestructive measurement method for the canopy phenotype of the watermelon plug seedlings based on deep learning.The Azure Kinect was used to shoot canopy color images,depth images,and RGB-D images of the watermelon plug seedlings.The Mask-RCNN network was used to classify,segment,and count the canopy leaves of the watermelon plug seedlings.To reduce the error of leaf area measurement caused by mutual occlusion of leaves,the leaves were repaired by CycleGAN,and the depth images were restored by image processing.Then,the Delaunay triangulation was adopted to measure the leaf area in the leaf point cloud.The YOLOX target detection network was used to identify the growing point position of each seedling on the plug tray.Then the depth differences between the growing point and the upper surface of the plug tray were calculated to obtain plant height.The experiment results show that the nondestructive measurement algorithm proposed in this paper achieves good measurement performance for the watermelon plug seedlings from the 1 true-leaf to 3 true-leaf stages.The average relative error of measurement is 2.33%for the number of true leaves,4.59%for the number of cotyledons,8.37%for the leaf area,and 3.27%for the plant height.The experiment results demonstrate that the proposed algorithm in this paper provides an effective solution for the nondestructive measurement of the canopy phenotype of the plug seedlings.
基金funded by the Beijing Engineering Research Center of Electric Rail Transportation.
文摘Effective partitioning is crucial for enabling parallel restoration of power systems after blackouts.This paper proposes a novel partitioning method based on deep reinforcement learning.First,the partitioning decision process is formulated as a Markov decision process(MDP)model to maximize the modularity.Corresponding key partitioning constraints on parallel restoration are considered.Second,based on the partitioning objective and constraints,the reward function of the partitioning MDP model is set by adopting a relative deviation normalization scheme to reduce mutual interference between the reward and penalty in the reward function.The soft bonus scaling mechanism is introduced to mitigate overestimation caused by abrupt jumps in the reward.Then,the deep Q network method is applied to solve the partitioning MDP model and generate partitioning schemes.Two experience replay buffers are employed to speed up the training process of the method.Finally,case studies on the IEEE 39-bus test system demonstrate that the proposed method can generate a high-modularity partitioning result that meets all key partitioning constraints,thereby improving the parallelism and reliability of the restoration process.Moreover,simulation results demonstrate that an appropriate discount factor is crucial for ensuring both the convergence speed and the stability of the partitioning training.
文摘This systematic review aims to comprehensively examine and compare deep learning methods for brain tumor segmentation and classification using MRI and other imaging modalities,focusing on recent trends from 2022 to 2025.The primary objective is to evaluate methodological advancements,model performance,dataset usage,and existing challenges in developing clinically robust AI systems.We included peer-reviewed journal articles and highimpact conference papers published between 2022 and 2025,written in English,that proposed or evaluated deep learning methods for brain tumor segmentation and/or classification.Excluded were non-open-access publications,books,and non-English articles.A structured search was conducted across Scopus,Google Scholar,Wiley,and Taylor&Francis,with the last search performed in August 2025.Risk of bias was not formally quantified but considered during full-text screening based on dataset diversity,validation methods,and availability of performance metrics.We used narrative synthesis and tabular benchmarking to compare performance metrics(e.g.,accuracy,Dice score)across model types(CNN,Transformer,Hybrid),imaging modalities,and datasets.A total of 49 studies were included(43 journal articles and 6 conference papers).These studies spanned over 9 public datasets(e.g.,BraTS,Figshare,REMBRANDT,MOLAB)and utilized a range of imaging modalities,predominantly MRI.Hybrid models,especially ResViT and UNetFormer,consistently achieved high performance,with classification accuracy exceeding 98%and segmentation Dice scores above 0.90 across multiple studies.Transformers and hybrid architectures showed increasing adoption post2023.Many studies lacked external validation and were evaluated only on a few benchmark datasets,raising concerns about generalizability and dataset bias.Few studies addressed clinical interpretability or uncertainty quantification.Despite promising results,particularly for hybrid deep learning models,widespread clinical adoption remains limited due to lack of validation,interpretability concerns,and real-world deployment barriers.
文摘Underwater pipeline inspection plays a vital role in the proactive maintenance and management of critical marine infrastructure and subaquatic systems.However,the inspection of underwater pipelines presents a challenge due to factors such as light scattering,absorption,restricted visibility,and ambient noise.The advancement of deep learning has introduced powerful techniques for processing large amounts of unstructured and imperfect data collected from underwater environments.This study evaluated the efficacy of the You Only Look Once(YOLO)algorithm,a real-time object detection and localization model based on convolutional neural networks,in identifying and classifying various types of pipeline defects in underwater settings.YOLOv8,the latest evolution in the YOLO family,integrates advanced capabilities,such as anchor-free detection,a cross-stage partial network backbone for efficient feature extraction,and a feature pyramid network+path aggregation network neck for robust multi-scale object detection,which make it particularly well-suited for complex underwater environments.Due to the lack of suitable open-access datasets for underwater pipeline defects,a custom dataset was captured using a remotely operated vehicle in a controlled environment.This application has the following assets available for use.Extensive experimentation demonstrated that YOLOv8 X-Large consistently outperformed other models in terms of pipe defect detection and classification and achieved a strong balance between precision and recall in identifying pipeline cracks,rust,corners,defective welds,flanges,tapes,and holes.This research establishes the baseline performance of YOLOv8 for underwater defect detection and showcases its potential to enhance the reliability and efficiency of pipeline inspection tasks in challenging underwater environments.
基金supported by the National Natural Science Foundation of China[grant number 62376217]the Young Elite Scientists Sponsorship Program by CAST[grant number 2023QNRC001]the Joint Research Project for Meteorological Capacity Improvement[grant number 24NLTSZ003]。
文摘Deep learning-based methods have become alternatives to traditional numerical weather prediction systems,offering faster computation and the ability to utilize large historical datasets.However,the application of deep learning to medium-range regional weather forecasting with limited data remains a significant challenge.In this work,three key solutions are proposed:(1)motivated by the need to improve model performance in data-scarce regional forecasting scenarios,the authors innovatively apply semantic segmentation models,to better capture spatiotemporal features and improve prediction accuracy;(2)recognizing the challenge of overfitting and the inability of traditional noise-based data augmentation methods to effectively enhance model robustness,a novel learnable Gaussian noise mechanism is introduced that allows the model to adaptively optimize perturbations for different locations,ensuring more effective learning;and(3)to address the issue of error accumulation in autoregressive prediction,as well as the challenge of learning difficulty and the lack of intermediate data utilization in one-shot prediction,the authors propose a cascade prediction approach that effectively resolves these problems while significantly improving model forecasting performance.The method achieves a competitive result in The East China Regional AI Medium Range Weather Forecasting Competition.Ablation experiments further validate the effectiveness of each component,highlighting their contributions to enhancing prediction performance.
基金supported by National Natural Science Foundation of China(NSFC)under grant U23A20310.
文摘With the growing advancement of wireless communication technologies,WiFi-based human sensing has gained increasing attention as a non-intrusive and device-free solution.Among the available signal types,Channel State Information(CSI)offers fine-grained temporal,frequency,and spatial insights into multipath propagation,making it a crucial data source for human-centric sensing.Recently,the integration of deep learning has significantly improved the robustness and automation of feature extraction from CSI in complex environments.This paper provides a comprehensive review of deep learning-enhanced human sensing based on CSI.We first outline mainstream CSI acquisition tools and their hardware specifications,then provide a detailed discussion of preprocessing methods such as denoising,time–frequency transformation,data segmentation,and augmentation.Subsequently,we categorize deep learning approaches according to sensing tasks—namely detection,localization,and recognition—and highlight representative models across application scenarios.Finally,we examine key challenges including domain generalization,multi-user interference,and limited data availability,and we propose future research directions involving lightweight model deployment,multimodal data fusion,and semantic-level sensing.
文摘Honeycombing Lung(HCL)is a chronic lung condition marked by advanced fibrosis,resulting in enlarged air spaces with thick fibrotic walls,which are visible on Computed Tomography(CT)scans.Differentiating between normal lung tissue,honeycombing lungs,and Ground Glass Opacity(GGO)in CT images is often challenging for radiologists and may lead to misinterpretations.Although earlier studies have proposed models to detect and classify HCL,many faced limitations such as high computational demands,lower accuracy,and difficulty distinguishing between HCL and GGO.CT images are highly effective for lung classification due to their high resolution,3D visualization,and sensitivity to tissue density variations.This study introduces Honeycombing Lungs Network(HCL Net),a novel classification algorithm inspired by ResNet50V2 and enhanced to overcome the shortcomings of previous approaches.HCL Net incorporates additional residual blocks,refined preprocessing techniques,and selective parameter tuning to improve classification performance.The dataset,sourced from the University Malaya Medical Centre(UMMC)and verified by expert radiologists,consists of CT images of normal,honeycombing,and GGO lungs.Experimental evaluations across five assessments demonstrated that HCL Net achieved an outstanding classification accuracy of approximately 99.97%.It also recorded strong performance in other metrics,achieving 93%precision,100%sensitivity,89%specificity,and an AUC-ROC score of 97%.Comparative analysis with baseline feature engineering methods confirmed the superior efficacy of HCL Net.The model significantly reduces misclassification,particularly between honeycombing and GGO lungs,enhancing diagnostic precision and reliability in lung image analysis.
基金supported by Key Science and Technology Program of Henan Province,China(Grant Nos.242102210147,242102210027)Fujian Province Young and Middle aged Teacher Education Research Project(Science and Technology Category)(No.JZ240101)(Corresponding author:Dong Yuan).
文摘Vehicle Edge Computing(VEC)and Cloud Computing(CC)significantly enhance the processing efficiency of delay-sensitive and computation-intensive applications by offloading compute-intensive tasks from resource-constrained onboard devices to nearby Roadside Unit(RSU),thereby achieving lower delay and energy consumption.However,due to the limited storage capacity and energy budget of RSUs,it is challenging to meet the demands of the highly dynamic Internet of Vehicles(IoV)environment.Therefore,determining reasonable service caching and computation offloading strategies is crucial.To address this,this paper proposes a joint service caching scheme for cloud-edge collaborative IoV computation offloading.By modeling the dynamic optimization problem using Markov Decision Processes(MDP),the scheme jointly optimizes task delay,energy consumption,load balancing,and privacy entropy to achieve better quality of service.Additionally,a dynamic adaptive multi-objective deep reinforcement learning algorithm is proposed.Each Double Deep Q-Network(DDQN)agent obtains rewards for different objectives based on distinct reward functions and dynamically updates the objective weights by learning the value changes between objectives using Radial Basis Function Networks(RBFN),thereby efficiently approximating the Pareto-optimal decisions for multiple objectives.Extensive experiments demonstrate that the proposed algorithm can better coordinate the three-tier computing resources of cloud,edge,and vehicles.Compared to existing algorithms,the proposed method reduces task delay and energy consumption by 10.64%and 5.1%,respectively.
基金financially supported by the National Science and Technology Major Project——Deep Earth Probe and Mineral Resources Exploration(No.2024ZD1003701)the National Key R&D Program of China(No.2022YFC2905004)。
文摘An image processing and deep learning method for identifying different types of rock images was proposed.Preprocessing,such as rock image acquisition,gray scaling,Gaussian blurring,and feature dimensionality reduction,was conducted to extract useful feature information and recognize and classify rock images using Tensor Flow-based convolutional neural network(CNN)and Py Qt5.A rock image dataset was established and separated into workouts,confirmation sets,and test sets.The framework was subsequently compiled and trained.The categorization approach was evaluated using image data from the validation and test datasets,and key metrics,such as accuracy,precision,and recall,were analyzed.Finally,the classification model conducted a probabilistic analysis of the measured data to determine the equivalent lithological type for each image.The experimental results indicated that the method combining deep learning,Tensor Flow-based CNN,and Py Qt5 to recognize and classify rock images has an accuracy rate of up to 98.8%,and can be successfully utilized for rock image recognition.The system can be extended to geological exploration,mine engineering,and other rock and mineral resource development to more efficiently and accurately recognize rock samples.Moreover,it can match them with the intelligent support design system to effectively improve the reliability and economy of the support scheme.The system can serve as a reference for supporting the design of other mining and underground space projects.
文摘The rapid growth of biomedical data,particularly multi-omics data including genomes,transcriptomics,proteomics,metabolomics,and epigenomics,medical research and clinical decision-making confront both new opportunities and obstacles.The huge and diversified nature of these datasets cannot always be managed using traditional data analysis methods.As a consequence,deep learning has emerged as a strong tool for analysing numerous omics data due to its ability to handle complex and non-linear relationships.This paper explores the fundamental concepts of deep learning and how they are used in multi-omics medical data mining.We demonstrate how autoencoders,variational autoencoders,multimodal models,attention mechanisms,transformers,and graph neural networks enable pattern analysis and recognition across all omics data.Deep learning has been found to be effective in illness classification,biomarker identification,gene network learning,and therapeutic efficacy prediction.We also consider critical problems like as data quality,model explainability,whether findings can be repeated,and computational power requirements.We now consider future elements of combining omics with clinical and imaging data,explainable AI,federated learning,and real-time diagnostics.Overall,this study emphasises the need of collaborating across disciplines to advance deep learning-based multi-omics research for precision medicine and comprehending complicated disorders.
基金supported by the Capital Fund for Health Improvement and Research,No.2022-2-2048(to WZ)the National Natural Science Foundation of China,No.81970992(to WZ)+3 种基金Capital Clinical Characteristic Application Research,No.Z121107001012161(to WZ)the Natural Science Foundation of Beijing,No.7082032(to WZ)the Key Technology R&D Program of Beijing Municipal Education Commission,No.KZ201610025030(to WZ)Project of Scientific and Technological Development of Traditional Chinese Medicine in Beijing,No.JJ2018-48(to WZ)。
文摘Alzheimer's disease is the most common type of cognitive disorder,and there is an urgent need to develop more effective,targeted and safer therapies for patients with this condition.Deep brain stimulation is an invasive surgical treatment that modulates abnormal neural activity by implanting electrodes into specific brain areas followed by electrical stimulation.As an emerging therapeutic approach,deep brain stimulation shows significant promise as a potential new therapy for Alzheimer's disease.Here,we review the potential mechanisms and therapeutic effects of deep brain stimulation in the treatment of Alzheimer's disease based on existing clinical and basic research.In clinical studies,the most commonly targeted sites include the fornix,the nucleus basalis of Meynert,and the ventral capsule/ventral striatum.Basic research has found that the most frequently targeted areas include the fornix,nucleus basalis of Meynert,hippocampus,entorhinal cortex,and rostral intralaminar thalamic nucleus.All of these individual targets exhibit therapeutic potential for patients with Alzheimer's disease and associated mechanisms of action have been investigated.Deep brain stimulation may exert therapeutic effects on Alzheimer's disease through various mechanisms,including reducing the deposition of amyloid-β,activation of the cholinergic system,increasing the levels of neurotrophic factors,enhancing synaptic activity and plasticity,promoting neurogenesis,and improving glucose metabolism.Currently,clinical trials investigating deep brain stimulation for Alzheimer's disease remain insufficient.In the future,it is essential to focus on translating preclinical mechanisms into clinical trials.Furthermore,consecutive follow-up studies are needed to evaluate the long-term safety and efficacy of deep brain stimulation for Alzheimer's disease,including cognitive function,neuropsychiatric symptoms,quality of life and changes in Alzheimer's disease biomarkers.Researchers must also prioritize the initiation of multi-center clinical trials of deep brain stimulation with large sample sizes and target earlier therapeutic windows,such as the prodromal and even the preclinical stages of Alzheimer's disease.Adopting these approaches will permit the efficient exploration of more effective and safer deep brain stimulation therapies for patients with Alzheimer's disease.
