BACKGROUND Dedicator of cytokinesis 8(DOCK 8) deficiency,also known as autosomal recessive hyper immunoglobulin E(IgE) syndrome,is a combined immunodeficiency disease that was first recognized in 2009.It is caused by ...BACKGROUND Dedicator of cytokinesis 8(DOCK 8) deficiency,also known as autosomal recessive hyper immunoglobulin E(IgE) syndrome,is a combined immunodeficiency disease that was first recognized in 2009.It is caused by genetic alterations(mutations or deletions) in the DOCK 8 gene and is characterized by multiple allergies,elevated IgE levels,and susceptibility to viral and bacterial infections.Early diagnosis is critical to optimize the success of stem cell transplantation.CASE SUMMARY This study reports the case of a pediatric patient with DOCK 8 deficiency who had negative genetic testing using multiplex primary immunodeficiency(PID) panel and whole-exome sequencing(WES) with a next-generation sequencing method.He presented with chronic diarrhea and was managed as celiac disease based on previous negative workup for immunodeficiency and duodenal biopsy.He developed a generalized vesicular rash which was thought to be dermatitis herpetiformis associated with celiac disease.However,it turned out to be Eczema herpeticum based on positive herpes simplex virus from blood and lesions.The diagnosis was re-evaluated after the child was found to have multiple viral,bacterial,and parasitic co-infections(herpes simplex virus,cytomegalovirus,Epstein-Barr virus,Salmonella,and cryptosporidiosis).Re-evaluation with target gene testing with copy number variation(CNV) analysis and Multiplex Ligation Probe Amplification(MLPA) showed a large homozygous deletion in the DOCK 8 gene,confirming the diagnosis of DOCK 8 deficiency.CONCLUSION Targeted gene testing with CNV analysis might detect deletions that can be missed by WES for diagnosing patients with PID.展开更多
Even when kids dont realize it,teachers listen with their ears and their hearts.So many teachers dedi-cate their lives to education and helping us raise good kids.Some of them go so far above and beyond the call of du...Even when kids dont realize it,teachers listen with their ears and their hearts.So many teachers dedi-cate their lives to education and helping us raise good kids.Some of them go so far above and beyond the call of duty that it makes you wonder if they are really angels in disguise.Stacy Caldwell is one of those teachers.展开更多
To many people,especially women at the Mzuzu Central Hospital(MCH)in the Northern Region of Malawi,Du Shumin is a familiar and respected name.This is because of her expertise in cervical cancer treatment and the many ...To many people,especially women at the Mzuzu Central Hospital(MCH)in the Northern Region of Malawi,Du Shumin is a familiar and respected name.This is because of her expertise in cervical cancer treatment and the many women,some of whom never dreamed of living a normal life again,that Du has helped.展开更多
BACKGROUND Depression is a common psychological disorder often associated with genetic,neurobiological,and psychosocial factors.This condition is characterized by low mood and decreased conscious activity and can lead...BACKGROUND Depression is a common psychological disorder often associated with genetic,neurobiological,and psychosocial factors.This condition is characterized by low mood and decreased conscious activity and can lead to severe consequences such as suicidal thoughts.Respiratory failure,a disorder of pulmonary ventilation and gas exchange,is frequently complicated by depression,aggravating the condition and creating complications in treatment.Patients with both conditions tend to exhibit poor compliance with medical advice,resulting in adverse outcomes such as sleep disorders,arrhythmias,and electrolyte imbalances.Therefore,effective nursing interventions are crucial for improving patient outcomes.While routine nursing care can provide basic support,dedicated nursing,which involves specialized and personalized care by highly trained professionals,may offer additional benefits.AIM To examine the effect of dedicated nursing intervention on medical advice compliance and adverse event incidence in patients with depression complicated by respiratory failure.METHODS A total of 160 patients with depression complicated by respiratory failure admitted to the Second Affiliated Hospital of Soochow University from January to December 2024 were randomly categorized into a control group(n=80)receiving routine nursing care and observation group(n=80)receiving routine nursing combined with dedicated nursing care.The establishment of a specialized nursing team;the development of a personalized nursing plan;and the implementation of comprehensive care strategies targeting emotional support,sleep improvement,pulmonary function enhancement,and adherence to medical advice were included in the dedicated nursing intervention.Emotional state[evaluated using the Self-Rating Depression Scale(SDS)],sleep quality[assessed using the Pittsburgh Sleep Quality Index(PSQI)],hope level[measured using the Herth Hope Scale(HHS)],pulmonary function[comprising forced vital capacity(FVC)and forced expiratory volume in the first second(FEV1)],exercise endurance[6-minute walk distance test(6MWD)],compliance with medical advice,and incidence of adverse events were compared between the two groups.RESULTS No significant differences were observed in SDS,PSQI,HHS,FVC,FEV1,6MWD,or compliance with medical advice between the two groups(P>0.05)before the intervention.However,after the intervention,the control group exhibited significantly lower SDS and PSQI scores;higher HHS scores;greater improvements in FVC,FEV1,and 6MWD;and higher compliance with medical advice compared with the control group(P<0.05).In addition,the incidence of adverse events was significantly lower in the control group(P<0.05).CONCLUSION Dedicated nursing intervention significantly improves emotional state,sleep quality,hope level,pulmonary function,exercise endurance,and compliance with medical advice while reducing adverse events in patients with depression complicated by respiratory failure.Therefore,dedicated nursing appears to be an effective approach to enhance patient outcomes in this population.展开更多
Dear Editor,We aimed to describe the management of the intraoperative injury of the right external iliac artery that occurred during robot-assisted right nephroureterectomy with bladder cuff excision.Surgery was sched...Dear Editor,We aimed to describe the management of the intraoperative injury of the right external iliac artery that occurred during robot-assisted right nephroureterectomy with bladder cuff excision.Surgery was scheduled for suspected urothelial carcinoma of the distal ureter in a 60-year-old woman.The patient involved in the present research signed a dedicated form to consent to the publication of images and/or information about her.Past medical history included Brugada syndrome diagnosed in 2015,and hypercholesterolemia.Past surgical history included one cesarean section only.Family history included ovarian cancer(sister),colorectal cancer(mother),and kidney cancer(father).展开更多
BACKGROUND Total neoadjuvant therapy(TNT)has been proposed as an advancement over standard long-course chemoradiotherapy(LCCRT)for the treatment of locally advanced rectal cancer(LARC).It has been suggested that TNT e...BACKGROUND Total neoadjuvant therapy(TNT)has been proposed as an advancement over standard long-course chemoradiotherapy(LCCRT)for the treatment of locally advanced rectal cancer(LARC).It has been suggested that TNT enhances resect-ability,improves treatment compliance,increases the rate of pathological comp-lete response,and reduces the risk of systemic recurrence.However,concerns have been raised that the prolonged interval to surgery associated with TNT,particularly in regimens such as the Rectal Cancer and Preoperative Induction Therapy Followed by Dedicated Operation(RAPIDO)protocol,may exacerbate fibrosis,leading to more technically challenging resections and poorer surgical outcomes.RAPIDO vs LCCRT.METHODS A single-center,retrospective cohort study was conducted of patients with LARC treated with TNT-RAPIDO or standard LCCRT followed by surgical resection between 2014 and 2024.A total of 99 patients with LARC were analyzed,inclu-ding 29 treated with TNT-RAPIDO and 70 treated with standard LCCRT.Demo-graphics,clinicopathological characteristics and early post-operative outcomes were compared between both groups.RESULTS Both groups were comparable in terms of demographics and clinicopathological characteristics.The median interval from initiation of neoadjuvant therapy to Core Tip:Rectal cancer and preoperative induction therapy followed by dedicated operation has emerged as a total neoadjuvant therapy strategy with improved oncological and functional outcomes.The impact of total neoadjuvant therapy on operative difficulty and short-term surgical outcomes,compared with long-course chemoradiotherapy,remains an area of ongoing debate.This cohort study of 99 patients demonstrated that the Rectal Cancer and Preoperative Induction Therapy Followed by Dedicated Operation(RAPIDO)protocol does not increase surgical difficulty or compromise early surgical outcomes compared with long-course chemoradiotherapy.It may also confer a shorter total stoma duration and a lower permanent stoma rate.randomized controlled trials in the future are warranted to more accurately assess the differences between TNT-RAPIDO and LCCRT in relation to oncological outcomes.展开更多
车载网VANET是一种应用于智能交通系统的新型无线移动自组织网络(mobile ad hoc network,MANET).随着车辆以及移动ad hoc网络技术的发展,车载网已经成为一个新兴的研究领域.针对VANET中车辆行驶的特征,提出一种拓扑相对稳定的车辆分簇算...车载网VANET是一种应用于智能交通系统的新型无线移动自组织网络(mobile ad hoc network,MANET).随着车辆以及移动ad hoc网络技术的发展,车载网已经成为一个新兴的研究领域.针对VANET中车辆行驶的特征,提出一种拓扑相对稳定的车辆分簇算法.在此算法基础上,根据专用短程通信(dedicated short range communication,DSRC)标准中控制信道(control channel,CCH)和服务信道(service channel,SCH)的分配,考虑车辆间的无线通信干扰和不同应用的QoS需求,提出一种基于分簇的多信道混合型MAC协议,簇内通信采用非竞争的TDMA机制,簇间通信采用基于竞争的CSMA?CA机制,相邻簇采用不同的服务信道.模拟实验表明,提出的MAC协议在同时满足实时应用的延迟需求和非实时应用的吞吐量方面,优于现有协议.展开更多
This special issue of the journal is dedicated to the recent research progress on human herpesviruses(HHVs).Human herpesviruses are distributed worldwide,and more than 90%of adults are infected by one or multiple HHVs...This special issue of the journal is dedicated to the recent research progress on human herpesviruses(HHVs).Human herpesviruses are distributed worldwide,and more than 90%of adults are infected by one or multiple HHVs.The HHV family contains three sub-families:the alpha sub-family[herpes simplex virus 1(HSV-1),HSV-2,展开更多
This special issue of the journal is dedicated to the important topic of oncogenic viruses and cancer.It contains seven review articles covering all known oncogenic viruses except for human T-lymphotropic virus type1(...This special issue of the journal is dedicated to the important topic of oncogenic viruses and cancer.It contains seven review articles covering all known oncogenic viruses except for human T-lymphotropic virus type1(HTLV-1).These review articles are contributed by experts on specific viruses and their associated human cancers.Viruses account for about 20%of total human cancer cases.Although many viruses can cause various tumors in animals,only seven of them展开更多
In this paper,we aim to unlock the potential of intelligent reflecting surfaces(IRSs)in cognitive internet of things(loT).Considering that the secondary IoT devices send messages to the secondary access point(SAP)by s...In this paper,we aim to unlock the potential of intelligent reflecting surfaces(IRSs)in cognitive internet of things(loT).Considering that the secondary IoT devices send messages to the secondary access point(SAP)by sharing the spectrum with the primary network,the interference is introduced by the IoT devices to the primary access point(PAP)which profits from the IoT devices by pricing the interference power charged by them.A practical path loss model is adopted such that the IRSs deployed between the IoT devices and SAP serve as diffuse scatterers,but each reflected signal can be aligned with its own desired direction.Moreover,two transmission policies of the secondary network are investigated without/with a successive interference cancellation(SIC)technique.The signal-to-interference plus noise ratio(SINR)balancing is considered to overcome the nearfar effect of the IoT devices so as to allocate the resource fairly among them.We propose a Stackelberg game strategy to characterize the interaction between primary and secondary networks.For the proposed game,the Stackelberg equilibrium is analytically derived to optimally obtain the closed-form solution of the power allocation and interference pricing.Numerical results are demonstrated to validate the performance of the theoretical derivations.展开更多
The study proposes an improved Harris hawks optimization(IHHO) algorithm by integrating the standard Harris hawks optimization(HHO) algorithm and mutation-based search mechanism for developing a high-performance machi...The study proposes an improved Harris hawks optimization(IHHO) algorithm by integrating the standard Harris hawks optimization(HHO) algorithm and mutation-based search mechanism for developing a high-performance machine learning solution for predicting soil compression index. HHO is a newly introduced meta-heuristic optimization algorithm(MOA) used to solve continuous search problems.Compared to the original HHO, the proposed IHHO can evade trapping in local optima, which in turn raises the search capabilities and enhances the search mechanism relying on mutation. Subsequently, a novel meta-heuristic-based soft computing technique called ELM-IHHO was established by integrating IHHO and extreme learning machine(ELM) to estimate soil compression index. A sum of 688 consolidation test data was collected for this purpose from an ongoing dedicated freight corridor railway project. To evaluate the generalization capability of the proposed ELM-IHHO model, a detailed comparison between ELM-IHHO and other well-established MOAs, such as particle swarm optimization,genetic algorithm, and biogeography-based optimization integrated with ELM, was performed. Based on the outcomes, the ELM-IHHO model exhibits superior performance over the other MOAs in predicting soil compression index.展开更多
Internet of things is deemed as the one of the great revolution after the age of Industrial Revolution.With the development of the communication technology,more and more entities are connected to the communication net...Internet of things is deemed as the one of the great revolution after the age of Industrial Revolution.With the development of the communication technology,more and more entities are connected to the communication network and become one of the elements in the network.Over recent decades,in the area of intelligent transportation,pedestrian and transport infrastructure are connected to the communication network to improve the driving safety and traffic efficiency which is known as the ICV(Intelligent Connected Vehicle).This paper summarizes the global ICV progresses in the past decades and the latest activities of ICV in China,and introduces various aspects regarding the recent development of the ICV,including industry development,spectrum and standard,at the same time.展开更多
Recently,the importance of vehicle safety supporting system has been highlighted as autonomous driving and platooning has attracted the researchers.To ensure driving safety,each vehicle must broadcast a basic safety m...Recently,the importance of vehicle safety supporting system has been highlighted as autonomous driving and platooning has attracted the researchers.To ensure driving safety,each vehicle must broadcast a basic safety message(BSM)every 100 ms.However,stable BSM exchange is difficult because of the changing environment and limited bandwidth of vehicular wireless communication.The increasing number of vehicles on the road increases the competition to access wireless networks for BSM exchange;this increases the packet collision rate.An increased packet collision rate impairs the transmission and reception of BSM information,which can easily cause a traffic accident.We propose a solution,the vehicular safety support system(V3S),which exchanges BSMs reliably even when many vehicles are on the road.The V3S uses a clustering scheme to decrease network traffic by reducing the amount of data exchanged between a vehicle and the roadside unit(RSU).In addition,the V3S reduces the collision rate of wireless network packets by broadcasting the vehicle’s BSM in an allocated timeslot using the time division multiple access(TDMA)MAC protocol.The V3S also deals with insufficient bandwidth for dedicated short-range communications(DSRC)by changing DSRC channels according to traffic flow.In evaluating the packet error rate for stable BSM packet delivery,the V3S demonstrates an excellent packet error rate of less than 1%,compared to the 802.11p with its packet error rate of 82%.展开更多
Peroral cholangioscopy is an important tool for diagnosis and treatment of various biliary disorders. Peroral cholangioscopy can be performed by using a dedicated cholangioscope that is advanced through the accessory ...Peroral cholangioscopy is an important tool for diagnosis and treatment of various biliary disorders. Peroral cholangioscopy can be performed by using a dedicated cholangioscope that is advanced through the accessory channel of a duodenoscope, or by direct insertion of a small-diameter endoscope into the bile duct. Direct peroral cholangioscopy refers to insertion of an ultraslim endoscope directly into the bile duct for visualization of the biliary mucosa and lumen. This approach provides a valuable and economic solution for diagnostic and therapeutic applications in the biliary tree. Compared to ductoscopy using a dedicated cholangioscope, the direct approach has several advantages and disadvantages. In this editorial, I discuss the advantages, disadvantages, and possible future developments pertaining to direct peroral cholangioscopy.展开更多
All the original references were provided by the Nobel Laureate Youyou Tu. The publication process involving the discovery of artemisinin was collected and sorted by her first Ph D student, Associate Professor Man-Yua...All the original references were provided by the Nobel Laureate Youyou Tu. The publication process involving the discovery of artemisinin was collected and sorted by her first Ph D student, Associate Professor Man-Yuan Wang. Through the publication of this article, the journal expects to provide a reference to the scientists who dedicated to the research of artemisinin, especially those who are interested in the discovery process of artemisinin.展开更多
Objective: This study aimed to explore the 100-year changes in regulations for the Florence Nightingale Medal.Methods: We used the announcements of the Florence Nightingale Medal awards as the research object to analy...Objective: This study aimed to explore the 100-year changes in regulations for the Florence Nightingale Medal.Methods: We used the announcements of the Florence Nightingale Medal awards as the research object to analyze-via historical and inductive methods-the regulations for receiving the Florence Nightingale Medal.Results: In the award years, the greatest number of winners per award year was 71 and the lowest was 12. The medal was initially exclusively awarded to living people but evolved to include both living and deceased people. The recipients were balanced among all countries. The gender of the winners showed a changing trend from being limited to only females to including both males and females.There was also a shift from emphasis on only dedication of the recipient to equal emphasis on both dedication and innovation.Conclusions: The selection criteria for recipients of the Florence Nightingale Medal evolved from consideration of those showing only dedication to equal consideration of both dedication and innovation.展开更多
Product storage policy, single picking volume and picking routing are the three factors of vital importance that affect the efficiency of a crane to pick goods in automated storage and retrieval systems(AS/RS). Compar...Product storage policy, single picking volume and picking routing are the three factors of vital importance that affect the efficiency of a crane to pick goods in automated storage and retrieval systems(AS/RS). Comparative experiments on picking efficiency were conducted targeting picking operation with order of 1 to 20. Based on dedicated and random storage policies, 4 picking methods of patching-based, S-type, return-type and optimized-type routes were used and compared in the experiments. The results show that either the dedicated policy or the random policy was applied, crane worked most efficiently with optimizedtype route, followed by S-type path, patching-based path, and return-type path. When the number of orders in a single picking is larger(more than 5), the random storage policy is preferable to the dedicated policy.展开更多
This special issue of the journal is dedicated to the recent progress on coronaviruses and covers the topics of viral epidemiology,virus replication and the interactions between the coronaviruses and their hosts.Membe...This special issue of the journal is dedicated to the recent progress on coronaviruses and covers the topics of viral epidemiology,virus replication and the interactions between the coronaviruses and their hosts.Members of the family Coronaviridae infect a wide range of vertebrates and humans.展开更多
This paper presents a halfway signaling exchange shared path protection(HSE-SPP)on the backup route for a fast connection recovery strategy.In the proposed HSE-SPP,a pre-assigned intermediate node on the backup route ...This paper presents a halfway signaling exchange shared path protection(HSE-SPP)on the backup route for a fast connection recovery strategy.In the proposed HSE-SPP,a pre-assigned intermediate node on the backup route is chosen for signaling exchange.When connection fails,source and destination nodes simultaneously generate backup connection setup messages to the pre-assigned intermediate node on the reserved backup route.At the intermediate node,signaling process occurs,and acknowledgment is generated for data transmission to the respective end nodes.Consequently,connection recovery time by applying HSE-SPP becomes very low.Simulations are performed for network parameters and results are verified with existing strategies.The average recovery time(RT),bandwidth blocking probability(BBP),bandwidth provisioning ratio(BPR),and resource overbuild(RO)ratio of HSE-SPP for ARPANET is 13.54 ms,0.18,3.02,0.55,and for dedicated path protection(DPP)are 13.20 ms,0.56,6.30,3.75 and for shared path protection(SPP)22.19 ms,0.22,3.23,0.70 respectively.Similarly,average RT,BBP,BPR and RO of HSE-SPP for COST239 are8.33 ms,0.04,1.64,0.26,and for DPP 4.23,0.47,3.50,2.04,and for SPP 11.81,0.08,1.66,0.27 respectively.Hence,results of the proposed strategy are better in terms of RT,BBP,BPR,and RO ratio.展开更多
文摘BACKGROUND Dedicator of cytokinesis 8(DOCK 8) deficiency,also known as autosomal recessive hyper immunoglobulin E(IgE) syndrome,is a combined immunodeficiency disease that was first recognized in 2009.It is caused by genetic alterations(mutations or deletions) in the DOCK 8 gene and is characterized by multiple allergies,elevated IgE levels,and susceptibility to viral and bacterial infections.Early diagnosis is critical to optimize the success of stem cell transplantation.CASE SUMMARY This study reports the case of a pediatric patient with DOCK 8 deficiency who had negative genetic testing using multiplex primary immunodeficiency(PID) panel and whole-exome sequencing(WES) with a next-generation sequencing method.He presented with chronic diarrhea and was managed as celiac disease based on previous negative workup for immunodeficiency and duodenal biopsy.He developed a generalized vesicular rash which was thought to be dermatitis herpetiformis associated with celiac disease.However,it turned out to be Eczema herpeticum based on positive herpes simplex virus from blood and lesions.The diagnosis was re-evaluated after the child was found to have multiple viral,bacterial,and parasitic co-infections(herpes simplex virus,cytomegalovirus,Epstein-Barr virus,Salmonella,and cryptosporidiosis).Re-evaluation with target gene testing with copy number variation(CNV) analysis and Multiplex Ligation Probe Amplification(MLPA) showed a large homozygous deletion in the DOCK 8 gene,confirming the diagnosis of DOCK 8 deficiency.CONCLUSION Targeted gene testing with CNV analysis might detect deletions that can be missed by WES for diagnosing patients with PID.
文摘Even when kids dont realize it,teachers listen with their ears and their hearts.So many teachers dedi-cate their lives to education and helping us raise good kids.Some of them go so far above and beyond the call of duty that it makes you wonder if they are really angels in disguise.Stacy Caldwell is one of those teachers.
文摘To many people,especially women at the Mzuzu Central Hospital(MCH)in the Northern Region of Malawi,Du Shumin is a familiar and respected name.This is because of her expertise in cervical cancer treatment and the many women,some of whom never dreamed of living a normal life again,that Du has helped.
基金Supported by the Second Nursing Research Project of the Humanities Nursing Professional Committee,No.RW2024PY03the Open Project of Suzhou Key Laboratory of Elderly Smart Nursing and Health Care in 2024.
文摘BACKGROUND Depression is a common psychological disorder often associated with genetic,neurobiological,and psychosocial factors.This condition is characterized by low mood and decreased conscious activity and can lead to severe consequences such as suicidal thoughts.Respiratory failure,a disorder of pulmonary ventilation and gas exchange,is frequently complicated by depression,aggravating the condition and creating complications in treatment.Patients with both conditions tend to exhibit poor compliance with medical advice,resulting in adverse outcomes such as sleep disorders,arrhythmias,and electrolyte imbalances.Therefore,effective nursing interventions are crucial for improving patient outcomes.While routine nursing care can provide basic support,dedicated nursing,which involves specialized and personalized care by highly trained professionals,may offer additional benefits.AIM To examine the effect of dedicated nursing intervention on medical advice compliance and adverse event incidence in patients with depression complicated by respiratory failure.METHODS A total of 160 patients with depression complicated by respiratory failure admitted to the Second Affiliated Hospital of Soochow University from January to December 2024 were randomly categorized into a control group(n=80)receiving routine nursing care and observation group(n=80)receiving routine nursing combined with dedicated nursing care.The establishment of a specialized nursing team;the development of a personalized nursing plan;and the implementation of comprehensive care strategies targeting emotional support,sleep improvement,pulmonary function enhancement,and adherence to medical advice were included in the dedicated nursing intervention.Emotional state[evaluated using the Self-Rating Depression Scale(SDS)],sleep quality[assessed using the Pittsburgh Sleep Quality Index(PSQI)],hope level[measured using the Herth Hope Scale(HHS)],pulmonary function[comprising forced vital capacity(FVC)and forced expiratory volume in the first second(FEV1)],exercise endurance[6-minute walk distance test(6MWD)],compliance with medical advice,and incidence of adverse events were compared between the two groups.RESULTS No significant differences were observed in SDS,PSQI,HHS,FVC,FEV1,6MWD,or compliance with medical advice between the two groups(P>0.05)before the intervention.However,after the intervention,the control group exhibited significantly lower SDS and PSQI scores;higher HHS scores;greater improvements in FVC,FEV1,and 6MWD;and higher compliance with medical advice compared with the control group(P<0.05).In addition,the incidence of adverse events was significantly lower in the control group(P<0.05).CONCLUSION Dedicated nursing intervention significantly improves emotional state,sleep quality,hope level,pulmonary function,exercise endurance,and compliance with medical advice while reducing adverse events in patients with depression complicated by respiratory failure.Therefore,dedicated nursing appears to be an effective approach to enhance patient outcomes in this population.
文摘Dear Editor,We aimed to describe the management of the intraoperative injury of the right external iliac artery that occurred during robot-assisted right nephroureterectomy with bladder cuff excision.Surgery was scheduled for suspected urothelial carcinoma of the distal ureter in a 60-year-old woman.The patient involved in the present research signed a dedicated form to consent to the publication of images and/or information about her.Past medical history included Brugada syndrome diagnosed in 2015,and hypercholesterolemia.Past surgical history included one cesarean section only.Family history included ovarian cancer(sister),colorectal cancer(mother),and kidney cancer(father).
文摘BACKGROUND Total neoadjuvant therapy(TNT)has been proposed as an advancement over standard long-course chemoradiotherapy(LCCRT)for the treatment of locally advanced rectal cancer(LARC).It has been suggested that TNT enhances resect-ability,improves treatment compliance,increases the rate of pathological comp-lete response,and reduces the risk of systemic recurrence.However,concerns have been raised that the prolonged interval to surgery associated with TNT,particularly in regimens such as the Rectal Cancer and Preoperative Induction Therapy Followed by Dedicated Operation(RAPIDO)protocol,may exacerbate fibrosis,leading to more technically challenging resections and poorer surgical outcomes.RAPIDO vs LCCRT.METHODS A single-center,retrospective cohort study was conducted of patients with LARC treated with TNT-RAPIDO or standard LCCRT followed by surgical resection between 2014 and 2024.A total of 99 patients with LARC were analyzed,inclu-ding 29 treated with TNT-RAPIDO and 70 treated with standard LCCRT.Demo-graphics,clinicopathological characteristics and early post-operative outcomes were compared between both groups.RESULTS Both groups were comparable in terms of demographics and clinicopathological characteristics.The median interval from initiation of neoadjuvant therapy to Core Tip:Rectal cancer and preoperative induction therapy followed by dedicated operation has emerged as a total neoadjuvant therapy strategy with improved oncological and functional outcomes.The impact of total neoadjuvant therapy on operative difficulty and short-term surgical outcomes,compared with long-course chemoradiotherapy,remains an area of ongoing debate.This cohort study of 99 patients demonstrated that the Rectal Cancer and Preoperative Induction Therapy Followed by Dedicated Operation(RAPIDO)protocol does not increase surgical difficulty or compromise early surgical outcomes compared with long-course chemoradiotherapy.It may also confer a shorter total stoma duration and a lower permanent stoma rate.randomized controlled trials in the future are warranted to more accurately assess the differences between TNT-RAPIDO and LCCRT in relation to oncological outcomes.
文摘车载网VANET是一种应用于智能交通系统的新型无线移动自组织网络(mobile ad hoc network,MANET).随着车辆以及移动ad hoc网络技术的发展,车载网已经成为一个新兴的研究领域.针对VANET中车辆行驶的特征,提出一种拓扑相对稳定的车辆分簇算法.在此算法基础上,根据专用短程通信(dedicated short range communication,DSRC)标准中控制信道(control channel,CCH)和服务信道(service channel,SCH)的分配,考虑车辆间的无线通信干扰和不同应用的QoS需求,提出一种基于分簇的多信道混合型MAC协议,簇内通信采用非竞争的TDMA机制,簇间通信采用基于竞争的CSMA?CA机制,相邻簇采用不同的服务信道.模拟实验表明,提出的MAC协议在同时满足实时应用的延迟需求和非实时应用的吞吐量方面,优于现有协议.
基金supported by grants from the Natural Science Foundation for Distinguished Young Scholars (81425017)the Ministry of Science and Technology of China (2016YFA0502100)+2 种基金the Key Project of the Natural Science Foundation of China (81230037)the National Institutes of Health (1R01AI116442) to KLthe Natural Science Foundation of China (81620108021) to MHL
文摘This special issue of the journal is dedicated to the recent research progress on human herpesviruses(HHVs).Human herpesviruses are distributed worldwide,and more than 90%of adults are infected by one or multiple HHVs.The HHV family contains three sub-families:the alpha sub-family[herpes simplex virus 1(HSV-1),HSV-2,
基金supported by Nature Science Foundation of China (NSFC 81130082)NIH grants AI097318 and AI091953supported by NIH grants DK094652,DK100257 and CA177337
文摘This special issue of the journal is dedicated to the important topic of oncogenic viruses and cancer.It contains seven review articles covering all known oncogenic viruses except for human T-lymphotropic virus type1(HTLV-1).These review articles are contributed by experts on specific viruses and their associated human cancers.Viruses account for about 20%of total human cancer cases.Although many viruses can cause various tumors in animals,only seven of them
基金This work was supported by the U.K.Engineering and Physical Sciences Research Council under Grants EP/P008402/2 and EP/R001588/1.
文摘In this paper,we aim to unlock the potential of intelligent reflecting surfaces(IRSs)in cognitive internet of things(loT).Considering that the secondary IoT devices send messages to the secondary access point(SAP)by sharing the spectrum with the primary network,the interference is introduced by the IoT devices to the primary access point(PAP)which profits from the IoT devices by pricing the interference power charged by them.A practical path loss model is adopted such that the IRSs deployed between the IoT devices and SAP serve as diffuse scatterers,but each reflected signal can be aligned with its own desired direction.Moreover,two transmission policies of the secondary network are investigated without/with a successive interference cancellation(SIC)technique.The signal-to-interference plus noise ratio(SINR)balancing is considered to overcome the nearfar effect of the IoT devices so as to allocate the resource fairly among them.We propose a Stackelberg game strategy to characterize the interaction between primary and secondary networks.For the proposed game,the Stackelberg equilibrium is analytically derived to optimally obtain the closed-form solution of the power allocation and interference pricing.Numerical results are demonstrated to validate the performance of the theoretical derivations.
文摘The study proposes an improved Harris hawks optimization(IHHO) algorithm by integrating the standard Harris hawks optimization(HHO) algorithm and mutation-based search mechanism for developing a high-performance machine learning solution for predicting soil compression index. HHO is a newly introduced meta-heuristic optimization algorithm(MOA) used to solve continuous search problems.Compared to the original HHO, the proposed IHHO can evade trapping in local optima, which in turn raises the search capabilities and enhances the search mechanism relying on mutation. Subsequently, a novel meta-heuristic-based soft computing technique called ELM-IHHO was established by integrating IHHO and extreme learning machine(ELM) to estimate soil compression index. A sum of 688 consolidation test data was collected for this purpose from an ongoing dedicated freight corridor railway project. To evaluate the generalization capability of the proposed ELM-IHHO model, a detailed comparison between ELM-IHHO and other well-established MOAs, such as particle swarm optimization,genetic algorithm, and biogeography-based optimization integrated with ELM, was performed. Based on the outcomes, the ELM-IHHO model exhibits superior performance over the other MOAs in predicting soil compression index.
文摘Internet of things is deemed as the one of the great revolution after the age of Industrial Revolution.With the development of the communication technology,more and more entities are connected to the communication network and become one of the elements in the network.Over recent decades,in the area of intelligent transportation,pedestrian and transport infrastructure are connected to the communication network to improve the driving safety and traffic efficiency which is known as the ICV(Intelligent Connected Vehicle).This paper summarizes the global ICV progresses in the past decades and the latest activities of ICV in China,and introduces various aspects regarding the recent development of the ICV,including industry development,spectrum and standard,at the same time.
基金This work was supported in part by the Chung-Ang University Research Grants in 2019,and in part by R&D Program for Forest Science Technology(Project No.“2021338C10-2123-CD02)provided by Korea Forest Service(Korea Forestry Promotion Institute).
文摘Recently,the importance of vehicle safety supporting system has been highlighted as autonomous driving and platooning has attracted the researchers.To ensure driving safety,each vehicle must broadcast a basic safety message(BSM)every 100 ms.However,stable BSM exchange is difficult because of the changing environment and limited bandwidth of vehicular wireless communication.The increasing number of vehicles on the road increases the competition to access wireless networks for BSM exchange;this increases the packet collision rate.An increased packet collision rate impairs the transmission and reception of BSM information,which can easily cause a traffic accident.We propose a solution,the vehicular safety support system(V3S),which exchanges BSMs reliably even when many vehicles are on the road.The V3S uses a clustering scheme to decrease network traffic by reducing the amount of data exchanged between a vehicle and the roadside unit(RSU).In addition,the V3S reduces the collision rate of wireless network packets by broadcasting the vehicle’s BSM in an allocated timeslot using the time division multiple access(TDMA)MAC protocol.The V3S also deals with insufficient bandwidth for dedicated short-range communications(DSRC)by changing DSRC channels according to traffic flow.In evaluating the packet error rate for stable BSM packet delivery,the V3S demonstrates an excellent packet error rate of less than 1%,compared to the 802.11p with its packet error rate of 82%.
文摘Peroral cholangioscopy is an important tool for diagnosis and treatment of various biliary disorders. Peroral cholangioscopy can be performed by using a dedicated cholangioscope that is advanced through the accessory channel of a duodenoscope, or by direct insertion of a small-diameter endoscope into the bile duct. Direct peroral cholangioscopy refers to insertion of an ultraslim endoscope directly into the bile duct for visualization of the biliary mucosa and lumen. This approach provides a valuable and economic solution for diagnostic and therapeutic applications in the biliary tree. Compared to ductoscopy using a dedicated cholangioscope, the direct approach has several advantages and disadvantages. In this editorial, I discuss the advantages, disadvantages, and possible future developments pertaining to direct peroral cholangioscopy.
文摘All the original references were provided by the Nobel Laureate Youyou Tu. The publication process involving the discovery of artemisinin was collected and sorted by her first Ph D student, Associate Professor Man-Yuan Wang. Through the publication of this article, the journal expects to provide a reference to the scientists who dedicated to the research of artemisinin, especially those who are interested in the discovery process of artemisinin.
基金supported by the Special Fund of Key Discipline Construction(the characteristic subject of Nursing course)of Shanxi Province in China
文摘Objective: This study aimed to explore the 100-year changes in regulations for the Florence Nightingale Medal.Methods: We used the announcements of the Florence Nightingale Medal awards as the research object to analyze-via historical and inductive methods-the regulations for receiving the Florence Nightingale Medal.Results: In the award years, the greatest number of winners per award year was 71 and the lowest was 12. The medal was initially exclusively awarded to living people but evolved to include both living and deceased people. The recipients were balanced among all countries. The gender of the winners showed a changing trend from being limited to only females to including both males and females.There was also a shift from emphasis on only dedication of the recipient to equal emphasis on both dedication and innovation.Conclusions: The selection criteria for recipients of the Florence Nightingale Medal evolved from consideration of those showing only dedication to equal consideration of both dedication and innovation.
基金Funded by National Social Science Foundation of China(16CGL018)the Soft Science Research Funds for Chengdu Science and Technology Project(2015-RK00-00206-ZF)the National United Engineering Laboratory of Integrated and Intelligent Transportation,Southwest Jiaotong University,China
文摘Product storage policy, single picking volume and picking routing are the three factors of vital importance that affect the efficiency of a crane to pick goods in automated storage and retrieval systems(AS/RS). Comparative experiments on picking efficiency were conducted targeting picking operation with order of 1 to 20. Based on dedicated and random storage policies, 4 picking methods of patching-based, S-type, return-type and optimized-type routes were used and compared in the experiments. The results show that either the dedicated policy or the random policy was applied, crane worked most efficiently with optimizedtype route, followed by S-type path, patching-based path, and return-type path. When the number of orders in a single picking is larger(more than 5), the random storage policy is preferable to the dedicated policy.
文摘This special issue of the journal is dedicated to the recent progress on coronaviruses and covers the topics of viral epidemiology,virus replication and the interactions between the coronaviruses and their hosts.Members of the family Coronaviridae infect a wide range of vertebrates and humans.
文摘This paper presents a halfway signaling exchange shared path protection(HSE-SPP)on the backup route for a fast connection recovery strategy.In the proposed HSE-SPP,a pre-assigned intermediate node on the backup route is chosen for signaling exchange.When connection fails,source and destination nodes simultaneously generate backup connection setup messages to the pre-assigned intermediate node on the reserved backup route.At the intermediate node,signaling process occurs,and acknowledgment is generated for data transmission to the respective end nodes.Consequently,connection recovery time by applying HSE-SPP becomes very low.Simulations are performed for network parameters and results are verified with existing strategies.The average recovery time(RT),bandwidth blocking probability(BBP),bandwidth provisioning ratio(BPR),and resource overbuild(RO)ratio of HSE-SPP for ARPANET is 13.54 ms,0.18,3.02,0.55,and for dedicated path protection(DPP)are 13.20 ms,0.56,6.30,3.75 and for shared path protection(SPP)22.19 ms,0.22,3.23,0.70 respectively.Similarly,average RT,BBP,BPR and RO of HSE-SPP for COST239 are8.33 ms,0.04,1.64,0.26,and for DPP 4.23,0.47,3.50,2.04,and for SPP 11.81,0.08,1.66,0.27 respectively.Hence,results of the proposed strategy are better in terms of RT,BBP,BPR,and RO ratio.
