Forbush decreases are depressions in the galactic cosmic rays (GCRs) that are caused primarily by modulations of interplanetary coronal mass ejections (ICMEs) but also occasionally by stream/corotating interaction reg...Forbush decreases are depressions in the galactic cosmic rays (GCRs) that are caused primarily by modulations of interplanetary coronal mass ejections (ICMEs) but also occasionally by stream/corotating interaction regions (SIRs/CIRs). Forbush decreases have been studied extensively using neutron monitors at Earth;recently, for the first time, they have been measured on the surface of another planet, Mars, by the Radiation Assessment Detector (RAD) on board the Mars Science Laboratory’s (MSL) rover Curiosity. The modulation of GCR particles by heliospheric transients in space is energy-dependent;afterwards, these particles interact with the Martian atmosphere, the interaction process depending on particle type and energy. In order to use ground-measured Forbush decreases to study the space weather environment near Mars, it is important to understand and quantify the energy-dependent modulation of the GCR particles by not only the pass-by heliospheric disturbances but also by the Martian atmosphere. Accordingly, this study presents a model that quantifies both at the Martian surface and in the interplanetary space near Mars the amplitudes of Forbush decreases at Mars during the pass-by of an ICME/SIR by combining the heliospheric modulation of GCRs with the atmospheric modification of such modulated GCR spectra. The modeled results are in good agreement with measurements of Forbush decreases caused by ICMEs/SIRs based on data collected by MSL on the surface of Mars and by the Mars Atmosphere and Volatile EvolutioN (MAVEN) spacecraft in orbit. Our model and these findings support the validity of both the Forbush decrease description and Martian atmospheric transport models.展开更多
The objective of this research is to investigate the effects of cosmic ray Forbush Decreases (FDs) exceeding 7% in magnitude, occurring between 1985 and 2016, on upper atmospheric pressure and temperature at Abha and ...The objective of this research is to investigate the effects of cosmic ray Forbush Decreases (FDs) exceeding 7% in magnitude, occurring between 1985 and 2016, on upper atmospheric pressure and temperature at Abha and Tabouk. Employing the super epoch analysis method, the study concentrated on altitudes of 5 km and 10 km, uncovering significant variations. Seasonal and synoptic-scale variations were considered and excluded when necessary across eight 9-day periods. Both locations showed considerable fluctuations in pressure and temperature before and after the events. At 5 km altitude (21 events), Abha experienced more pressure increases both before (9 vs. 7) and after (12 vs. 11) the events compared to Tabouk. For temperature, Abha recorded more increases before the events (5 vs. 1), while Tabouk showed more decreases (19 vs. 15). Post-event, Tabouk had more temperature increases (13 vs. 10). At 10 km altitude (20 events), both regions experienced more decreases than increases in pressure and temperature before the events and more increases afterward. Notably, Abha experienced more pressure increases both 4 days before (9 vs. 7) and after the events (12 vs. 11) than Tabouk. For temperature, Abha recorded more increases before the events (5 vs. 1), while Tabouk showed more decreases (19 vs. 15). Post-event, Tabouk had more temperature increases (13 vs. 10). These findings underscore both similarities and differences in atmospheric responses to FDs between Abha and Tabouk. Both locations exhibited cooling trends before and warming trends after the events, with Tabouk demonstrating a more pronounced warming trend post-event. These results enhance our understanding of the atmospheric dynamics linked to FDs and assist in predicting weather patterns associated with these phenomena.展开更多
A cosmic-ray muon telescope the telescope was built in the Zhongshan has been collecting data since the end Station of Antarctica. The telescope of 2014, which was shortly after is the first observation device to be b...A cosmic-ray muon telescope the telescope was built in the Zhongshan has been collecting data since the end Station of Antarctica. The telescope of 2014, which was shortly after is the first observation device to be built by Chinese scientists in Antarctica. The pressure change is very strong in Zhongshan station. The count rate of the pressure correction results shows that the large variations in the count rate are likely caused by pressure fluctuations. During the period from 18 June to 22 June 2015, four halo coronal mass ejections （CMEs） were ejected from the Sun. These CMEs initiated a series of Forbush decreases （FD） when they reached the Earth. We conducted a comprehensive study of the intensity fluctuations of galactic cosmic rays recorded during FDs. The intensity fluctuations used in this study were collected by cosmic ray detectors of multiple stations （Zhongshan, McMurdo, South Polar, and Nagoya）, and the solar wind measurements were collected by ACE and WIND. The profile of the FD of 22 June demonstrated a four-step decrease. The traditional one- or two-step FD classification method does not adequately explain the FD profile results. The interaction between the faster CME that occurred on 21 June 2015 and the two slow CMEs of the earlier few days should be considered. The cosmic ray intensities of the South Pole, McMurdo, and Zhongshan stations have similar hourly variations, whereas the galactic cosmic rays recorded between polar and non-polar locations are distinct. The FD pre-increase of 22 June 2015 for the Nagoya ninon telescope （non-polar location） lags those of the McMurdo and Zhongshan stations （polar locations） by 1 h. The FD onset of 22 June 2015 for the Nagoya muon telescope lags those of the polar locations by 1 h.展开更多
The honey badger algorithm(HBA),as a new swarm intelligence(SI)optimization algorithm,has shown certain effectiveness in its applications.Aiming at the problems of unsatisfactory initial population distribution of HBA...The honey badger algorithm(HBA),as a new swarm intelligence(SI)optimization algorithm,has shown certain effectiveness in its applications.Aiming at the problems of unsatisfactory initial population distribution of HBA,poor ability to avoid local optimum,and slow convergence speed,this paper proposes a multi-strategy improved HBA based on periodical mutation and t-distribution perturbation,called MHBA.Firstly,a good point set population initialization is introduced to get a uniform initial population.Secondly,periodic mutation and t-distribution perturbation are successively used to improve the algorithm’s ability to avoid local optimum.Finally,the density factor is improved for balancing exploration and exploitation.By comparing MHBA with HBA and 7 other SIs on 6 benchmark functions,it is evident that the performance of MHBA is far superior to HBA.In addition,by applying MHBA to robot path planning,MHBA can identify the shortest path more quickly and consistently compared with competitors.展开更多
Cellular senescence and its senescence-associated secretory phenotype(SASP)represent a pivotal role in the development of skeletal diseases.Targeted elimination or rejuvenation of senescent cells has shown potential a...Cellular senescence and its senescence-associated secretory phenotype(SASP)represent a pivotal role in the development of skeletal diseases.Targeted elimination or rejuvenation of senescent cells has shown potential as a therapeutic strategy to reverse age-related skeletal senescence and promote bone regeneration.Meanwhile,other age-related mechanisms,involving altered cellular functions,impaired intercellular crosstalk,disturbed tissue microenvironment,and decreased regenerative capacity,synergistically contribute to the pathogenesis.In this review,we outline the cellular senescence and other age-related mechanisms in developing skeletal diseases,including osteoporosis,intervertebral disc degeneration,osteoarthritis,rheumatoid arthritis,bone tumors and ankylosing spondylitis,with the aim of comprehensively understanding their detrimental effects on the aged skeleton and screening the potential targets for anti-aging therapy within the skeletal system.展开更多
Soil microbial communities and grassland ecosystem processes are increasingly confronted with multiple global change factors(GCFs).There is still a lack of research on how these multiple GCFs interact and impact soil ...Soil microbial communities and grassland ecosystem processes are increasingly confronted with multiple global change factors(GCFs).There is still a lack of research on how these multiple GCFs interact and impact soil microbial communities and their functions.To address this gap,we conducted a simulation experiment to examine the individual and interactive effects of the four most critical and prevalent GCFs,elevated carbon dioxide concentration(eCO_(2)),elevated temperature(eT),decreased precipitation(dP),and elevated nitrogen(N)deposition(eN).This study focused on their effects on soil physicochemical properties,bacterial and fungal communities,and extracellular enzyme activities(EEAs)related to carbon(C),N,and phosphorus(P)cycles in a temperate grassland.Results showed that eCO_(2),eN,and dP tended to increase EEAs,while having neutral effects on microbial diversity and community composition.On the other hand,eT resulted in decreases in soil pH,total C,total N,EEAs,and microbial diversity,but increases in plant biomass,total P,microbial richness,and network complexity and stability.This shift in the nutrient limitation from P to N under warming conditions resulted in decoupling of nutrients.Neutral or slightly negative relationships were found between enzyme activities and microbial richness,diversity,and dominant species,and the responses of microbial communities and ecological functions were asynchronous under GCFs.Importantly,our results revealed significant higher-order interactions among GCFs and found that they had notable effects on soil physicochemical properties as well as on microbial communities and ecological functions.These findings provide valuable insights and suggestions for ecological adaptations to future global changes.展开更多
In the context of the prevalent winter air quality issues in China marked by declining PM_(2.5)and rising O_(3),this study employed amodified WRF-Chem model to examine the aerosol radiation interaction(ARI),heterogene...In the context of the prevalent winter air quality issues in China marked by declining PM_(2.5)and rising O_(3),this study employed amodified WRF-Chem model to examine the aerosol radiation interaction(ARI),heterogeneous chemistry(AHC),and their combined impact(ALL)on the variations in O_(3)and PM_(2.5)during the 2014–2020 in eastern China.Our analysis confirmed that ARI curtailed O_(3)while elevating PM_(2.5).AHC reduced O_(3)through heterogeneous absorption of NOx and hydroxideswhile notably fostering fine-grained sulfate,resulting in a PM_(2.5)increase.Emission reductions mitigated the inhibitory impact of ARI on meteorological fields and photolysis rates.Emission reduction individually without aerosol feedback led to a 5.43 ppb O_(3)increase and a 22.89μg/m^(3)PM_(2.5)decrease.ARI and AHC amplified the emission-reduction-induced(ERI)O_(3)rise by 1.83 and 0.31 ppb,respectively.The response of ARI to emission diminution brought about a modest PM_(2.5)increase of 0.31μg/m^(3).Conversely,AHC,acting as the primary contributor,caused a noteworthy PM_(2.5)decrease of 4.60μg/m^(3).As efforts concentrate on reducing PM_(2.5),the promotion of ARI on PM_(2.5)counterbalanced the efficacy of emission reduction and the AHC-induced strengthening of PM_(2.5)decrease.The ALL magnified the ERI O_(3)increase by 38.9%and PM_(2.5)decrease by 18.7%.Sensitivity experiments with different degrees of emission reduction demonstrated a consistent linear relationship between the ALL-induced enhancement of O_(3)increase and PM_(2.5)decrease to the ERI PM_(2.5)decline.Our investigation revealed the complex connection between emissions and aerosol feedback in influencing air quality.展开更多
Objectives:Short video addiction has emerged as a significant public health issue in recent years,with a growing trend toward severity.However,research on the causes and impacts of short video addiction remains limite...Objectives:Short video addiction has emerged as a significant public health issue in recent years,with a growing trend toward severity.However,research on the causes and impacts of short video addiction remains limited,and understanding of the variable“TikTok brain”is still in its infancy.Therefore,based on the Stimulus-Organism-Behavior-Consequence(SOBC)framework,we proposed six research hypotheses and constructed a model to explore the relationships between short video usage intensity,TikTok brain,short video addiction,and decreased attention control.Methods:Given that students are considered a high-risk group for excessive short video use,we collected 1086 valid participants from Chinese student users,including 609 males(56.1%)and 477 females(43.9%),with an average participant age of 19.84 years,to test the hypotheses.Results:(1)Short video usage intensity was positively related to short video addiction,TikTok brain,and decreased attention control;(2)TikTok brain was positively related to short video addiction and decreased attention control;and(3)Short video addiction was positively related to decreased attention control.Conclusions:These findings suggest that although excessive use of short video applications brings negative consequences,users still spend significant amounts of time on these platforms,indicating a need for strict self-regulation of usage time.展开更多
The discontinuation of denosumab[antibody targeting receptor activator of nuclear factor kappa B ligand(RANKL)]therapy may increase the risk of multiple vertebral fractures;however,the underlying pathophysiology is la...The discontinuation of denosumab[antibody targeting receptor activator of nuclear factor kappa B ligand(RANKL)]therapy may increase the risk of multiple vertebral fractures;however,the underlying pathophysiology is largely unknown.In patients who underwent discontinuation after multiple injections of denosumab,the levels of tartrate-resistant acid phosphatase 5b increased compared to pretreatment levels,indicating a phenomenon known as“overshoot.”The rate of decrease in bone mineral density during the withdrawal period was higher than the rate of decrease associated with aging,suggesting that the physiological bone metabolism had broken down.Overshoot and significant bone loss were also observed in mice receiving continuous administration of anti-RANKL antibody after treatment was interrupted,resembling the original pathology.In mice long out of overshoot,bone resorption recovered,but osteoblast numbers and bone formation remained markedly reduced.The bone marrow exhibited a significant reduction in stem cell(SC)antigen 1-and platelet-derived growth factor receptor alpha-expressing osteoblast progenitors(PαS cells)and alkaline phosphatase-positive early osteoblasts.Just before the overshoot phase,the osteoclast precursor cell population expands and RANKL-bearing extracellular vesicles(EVs)became abundant in the serum,leading to robust osteoclastogenesis after cessation of anti-RANKL treatment.Thus,accelerated bone resorption due to the accumulation of RANKLbearing EVs and long-term suppression of bone formation uncoupled from bone resorption leads to the severe bone loss characteristic of denosumab discontinuation.展开更多
Weight loss,whether resulting from disease-related conditions or intentional interventions,has been increasingly recognized as a significant risk factor for compromised skeletal integrity.While moderate weight reducti...Weight loss,whether resulting from disease-related conditions or intentional interventions,has been increasingly recognized as a significant risk factor for compromised skeletal integrity.While moderate weight reduction may yield metabolic benefits,rapid or sustained weight loss is frequently associated with decreased bone mineral density,deterioration of bone microarchitecture,and heightened fracture risk.The mechanisms underlying weight loss–induced bone loss are complex and multifactorial.Emerging evidence highlights a range of contributing factors,including reduced mechanical loading,increased bone marrow adiposity,hormonal and endocrine alterations,nutritional deficiencies,and disruptions in energy metabolism.These mechanisms are intricately interconnected,ultimately impairing bone remodeling and homeostatic balance.In this review,we provide a comprehensive analysis of the current literature on the mechanistic pathways,clinical consequences,and therapeutic strategies related to weight loss–induced bone loss.We further differentiate the skeletal effects of disease-associated versus interventioninduced weight loss,with a focus on their distinct molecular underpinnings.Our goal is to offer novel insights into the optimization of bone health management in the context of weight loss,guided by a translational medicine perspective.展开更多
Nonlinear transforms have significantly advanced learned image compression(LIC),particularly using residual blocks.This transform enhances the nonlinear expression ability and obtain compact feature representation by ...Nonlinear transforms have significantly advanced learned image compression(LIC),particularly using residual blocks.This transform enhances the nonlinear expression ability and obtain compact feature representation by enlarging the receptive field,which indicates how the convolution process extracts features in a high dimensional feature space.However,its functionality is restricted to the spatial dimension and network depth,limiting further improvements in network performance due to insufficient information interaction and representation.Crucially,the potential of high dimensional feature space in the channel dimension and the exploration of network width/resolution remain largely untapped.In this paper,we consider nonlinear transforms from the perspective of feature space,defining high-dimensional feature spaces in different dimensions and investigating the specific effects.Firstly,we introduce the dimension increasing and decreasing transforms in both channel and spatial dimensions to obtain high dimensional feature space and achieve better feature extraction.Secondly,we design a channel-spatial fusion residual transform(CSR),which incorporates multi-dimensional transforms for a more effective representation.Furthermore,we simplify the proposed fusion transform to obtain a slim architecture(CSR-sm),balancing network complexity and compression performance.Finally,we build the overall network with stacked CSR transforms to achieve better compression and reconstruction.Experimental results demonstrate that the proposed method can achieve superior ratedistortion performance compared to the existing LIC methods and traditional codecs.Specifically,our proposed method achieves 9.38%BD-rate reduction over VVC on Kodak dataset.展开更多
In order to solve the multiple power extreme value point problem caused by system frequency splitting during wireless energy transmission at short distances a transmission model of the system is established.With the c...In order to solve the multiple power extreme value point problem caused by system frequency splitting during wireless energy transmission at short distances a transmission model of the system is established.With the comprehensive consideration of the resonance frequency load parameters and the coupling between coils the internal factors of frequency splitting and boundary conditions are discussed.The results show that under the condition of the fixed load the higher the natural resonance frequency the easier the frequency splitting. As the frequency splitting occurs the frequency of the maximum power transfer is no longer with the natural resonance frequency which can make the system unstable and the transfer power more difficult to control. Therefore a decreasing-frequency method is proposed to avoid the system frequency splitting. And decreasing the system resonance frequency can make the system successfully withdraw the frequency splitting area at a short-distance range.Under the fixed load condition the transmission power of the system can be increased by 400% and the transmission efficiency is reduced by only 14% which greatly improves the transmission performance of the system.展开更多
AIM： To investigate the effects of long-term albumin administration on survival, recurrence of ascites and onset of other complications. METHODS： One hundred consecutive patients admitted for first-onset ascites wer...AIM： To investigate the effects of long-term albumin administration on survival, recurrence of ascites and onset of other complications. METHODS： One hundred consecutive patients admitted for first-onset ascites were randomized to receive diuretics plus human albumin 25 g/wk in the first year and 25 g every two wk thereafter （group 1） or diuretics alone （group 2）. The primary endpoint was survival without liver transplantation. Secondary endpoints were recurrence of ascites and occurrence of other complications. RESULTS： Median follow-up was 84 （2-120） mo. Albu- min-treated patients had significantly greater cumulative survival rate （Breslow test= 7.05, P= 0.0078） and lower probability of ascites recurrence （51% versus 94%, P〈0.0001）. Chronic albumin infusion resulted in a mean increase in survival of 16 mo. CONCLUSION： Long-term albumin administration after first-onset ascites significantly improves patients＇ survival and decreases the risk of ascites recurrence.展开更多
In full waveform inversion （FWI）, Hessian information of the misfit function is of vital importance for accelerating the convergence of the inversion; however, it usually is not feasible to directly calculate the He...In full waveform inversion （FWI）, Hessian information of the misfit function is of vital importance for accelerating the convergence of the inversion; however, it usually is not feasible to directly calculate the Hessian matrix and its inverse. Although the limited memory Broyden-Fletcher-Goldfarb-Shanno （L-BFGS） or Hessian-free inexact Newton （HFN） methods are able to use approximate Hessian information, the information they collect is limited. The two methods can be interlaced because they are able to provide Hessian information for each other; however, the performance of the hybrid iterative method is dependent on the effective switch between the two methods. We have designed a new scheme to realize the dynamic switch between the two methods based on the decrease ratio （DR） of the misfit function （objective function）, and we propose a modified hybrid iterative optimization method. In the new scheme, we compare the DR of the two methods for a given computational cost, and choose the method with a faster DR. Using these steps, the modified method always implements the most efficient method. The results of Marmousi and overthrust model testings indicate that the convergence with our modified method is significantly faster than that in the L-BFGS method with no loss of inversion quality. Moreover, our modified outperforms the enriched method by a little speedup of the convergence. It also exhibits better efficiency than the HFN method.展开更多
In this paper the computer code of AUTOUGH2 is used to carry out numerical simulation study on the Wuqing geothermal reservoir for evaluating reservoir performance upon different exploitation schemes.The simulating ca...In this paper the computer code of AUTOUGH2 is used to carry out numerical simulation study on the Wuqing geothermal reservoir for evaluating reservoir performance upon different exploitation schemes.The simulating calculation and analysis of two main cases,production without reinjection and production with reinjection,were carried out to illuminate and compare the temperature and pressure profiles with distance and time.The water level or pressure will decrease with the time of production,and the reinjection will cause the cooling effect of reinjection on the production zone.展开更多
Based on the summer precipitation data from 53 stations in Liaoning Province and sea surface temperature(SST) data of Hadley Center in 1961-2009,the decadal variation of the relationship between summer precipitation a...Based on the summer precipitation data from 53 stations in Liaoning Province and sea surface temperature(SST) data of Hadley Center in 1961-2009,the decadal variation of the relationship between summer precipitation and SST over Nino3 oceanic regions in the previous autumn was studied.The results showed that their correlation was decreased obviously in recent 30 years.In 1961-1974,summer rainfall could be forecasted according to the SST anomaly over Nino3 oceanic regions in the previous autumn,and there were above 25 stations with the sign accuracy of over 66.7%.However,there were only five stations with the same accuracy during 1980-2009.From 1961 to 1974,25 stations showed block distribution in the central and northeastern Liaoning,but the distribution of five stations was spotty in 1980-2009.Before the middle and latter half of the 1970s,Liaoning had more(less) summer rainfall when SST over the equatorial central and eastern Pacific was higher(lower) in the previous autumn.However,it was difficult to build indicative relationship above since 1980s.展开更多
Because of the low convergence accuracy of the basic Harris Hawks algorithm,which quickly falls into the local optimal,a Harris Hawks algorithm combining tuna swarm algorithm and differential mutation strategy(TDHHO)i...Because of the low convergence accuracy of the basic Harris Hawks algorithm,which quickly falls into the local optimal,a Harris Hawks algorithm combining tuna swarm algorithm and differential mutation strategy(TDHHO)is proposed.The escape energy factor of nonlinear periodic energy decline balances the ability of global exploration and regional development.The parabolic foraging approach of the tuna swarm algorithm is introduced to enhance the global exploration ability of the algorithm and accelerate the convergence speed.The difference variation strategy is used to mutate the individual position and calculate the fitness,and the fitness of the original individual position is compared.The greedy technique is used to select the one with better fitness of the objective function,which increases the diversity of the population and improves the possibility of the algorithm jumping out of the local extreme value.The test function tests the TDHHO algorithm,and compared with other optimization algorithms,the experimental results show that the convergence speed and optimization accuracy of the improved Harris Hawks are improved.Finally,the enhanced Harris Hawks algorithm is applied to engineering optimization and wireless sensor networks(WSN)coverage optimization problems,and the feasibility of the TDHHO algorithm in practical application is further verified.展开更多
基金supported by the Strategic Priority Program of the Chinese Academy of Sciences (Grant No.XDB41000000 and XDA15017300)the Key Research Program of the Chinese Academy of Sciences (Grant No.XDPB11 and QYZDBSSW-DQC015)+3 种基金the CNSA pre-research Project on Civil Aerospace Technologies (Grant No.D020104)National Natural Science Foundation of China (Grant No.41842037)the German Aerospace Center (DLR) and DLR’s Space Administration grants 50QM0501, 50QM1201 and 50QM1701support by the Croatian Science Foundation under the project 7549 (MSOC) and EUH2020 grant agreement No 824135 (project SOLARNET)
文摘Forbush decreases are depressions in the galactic cosmic rays (GCRs) that are caused primarily by modulations of interplanetary coronal mass ejections (ICMEs) but also occasionally by stream/corotating interaction regions (SIRs/CIRs). Forbush decreases have been studied extensively using neutron monitors at Earth;recently, for the first time, they have been measured on the surface of another planet, Mars, by the Radiation Assessment Detector (RAD) on board the Mars Science Laboratory’s (MSL) rover Curiosity. The modulation of GCR particles by heliospheric transients in space is energy-dependent;afterwards, these particles interact with the Martian atmosphere, the interaction process depending on particle type and energy. In order to use ground-measured Forbush decreases to study the space weather environment near Mars, it is important to understand and quantify the energy-dependent modulation of the GCR particles by not only the pass-by heliospheric disturbances but also by the Martian atmosphere. Accordingly, this study presents a model that quantifies both at the Martian surface and in the interplanetary space near Mars the amplitudes of Forbush decreases at Mars during the pass-by of an ICME/SIR by combining the heliospheric modulation of GCRs with the atmospheric modification of such modulated GCR spectra. The modeled results are in good agreement with measurements of Forbush decreases caused by ICMEs/SIRs based on data collected by MSL on the surface of Mars and by the Mars Atmosphere and Volatile EvolutioN (MAVEN) spacecraft in orbit. Our model and these findings support the validity of both the Forbush decrease description and Martian atmospheric transport models.
文摘The objective of this research is to investigate the effects of cosmic ray Forbush Decreases (FDs) exceeding 7% in magnitude, occurring between 1985 and 2016, on upper atmospheric pressure and temperature at Abha and Tabouk. Employing the super epoch analysis method, the study concentrated on altitudes of 5 km and 10 km, uncovering significant variations. Seasonal and synoptic-scale variations were considered and excluded when necessary across eight 9-day periods. Both locations showed considerable fluctuations in pressure and temperature before and after the events. At 5 km altitude (21 events), Abha experienced more pressure increases both before (9 vs. 7) and after (12 vs. 11) the events compared to Tabouk. For temperature, Abha recorded more increases before the events (5 vs. 1), while Tabouk showed more decreases (19 vs. 15). Post-event, Tabouk had more temperature increases (13 vs. 10). At 10 km altitude (20 events), both regions experienced more decreases than increases in pressure and temperature before the events and more increases afterward. Notably, Abha experienced more pressure increases both 4 days before (9 vs. 7) and after the events (12 vs. 11) than Tabouk. For temperature, Abha recorded more increases before the events (5 vs. 1), while Tabouk showed more decreases (19 vs. 15). Post-event, Tabouk had more temperature increases (13 vs. 10). These findings underscore both similarities and differences in atmospheric responses to FDs between Abha and Tabouk. Both locations exhibited cooling trends before and warming trends after the events, with Tabouk demonstrating a more pronounced warming trend post-event. These results enhance our understanding of the atmospheric dynamics linked to FDs and assist in predicting weather patterns associated with these phenomena.
文摘A cosmic-ray muon telescope the telescope was built in the Zhongshan has been collecting data since the end Station of Antarctica. The telescope of 2014, which was shortly after is the first observation device to be built by Chinese scientists in Antarctica. The pressure change is very strong in Zhongshan station. The count rate of the pressure correction results shows that the large variations in the count rate are likely caused by pressure fluctuations. During the period from 18 June to 22 June 2015, four halo coronal mass ejections （CMEs） were ejected from the Sun. These CMEs initiated a series of Forbush decreases （FD） when they reached the Earth. We conducted a comprehensive study of the intensity fluctuations of galactic cosmic rays recorded during FDs. The intensity fluctuations used in this study were collected by cosmic ray detectors of multiple stations （Zhongshan, McMurdo, South Polar, and Nagoya）, and the solar wind measurements were collected by ACE and WIND. The profile of the FD of 22 June demonstrated a four-step decrease. The traditional one- or two-step FD classification method does not adequately explain the FD profile results. The interaction between the faster CME that occurred on 21 June 2015 and the two slow CMEs of the earlier few days should be considered. The cosmic ray intensities of the South Pole, McMurdo, and Zhongshan stations have similar hourly variations, whereas the galactic cosmic rays recorded between polar and non-polar locations are distinct. The FD pre-increase of 22 June 2015 for the Nagoya ninon telescope （non-polar location） lags those of the McMurdo and Zhongshan stations （polar locations） by 1 h. The FD onset of 22 June 2015 for the Nagoya muon telescope lags those of the polar locations by 1 h.
基金Supported by the National Key Research and Development Program of China(No.2022ZD0119001)。
文摘The honey badger algorithm(HBA),as a new swarm intelligence(SI)optimization algorithm,has shown certain effectiveness in its applications.Aiming at the problems of unsatisfactory initial population distribution of HBA,poor ability to avoid local optimum,and slow convergence speed,this paper proposes a multi-strategy improved HBA based on periodical mutation and t-distribution perturbation,called MHBA.Firstly,a good point set population initialization is introduced to get a uniform initial population.Secondly,periodic mutation and t-distribution perturbation are successively used to improve the algorithm’s ability to avoid local optimum.Finally,the density factor is improved for balancing exploration and exploitation.By comparing MHBA with HBA and 7 other SIs on 6 benchmark functions,it is evident that the performance of MHBA is far superior to HBA.In addition,by applying MHBA to robot path planning,MHBA can identify the shortest path more quickly and consistently compared with competitors.
基金supported by the National Natural Science Foundation of China(82172468,82372436)Outstanding Youth Fund of Jiangsu Province(BK2024047)+1 种基金China Postdoctoral Science Foundation(2023T160553)Postgraduate Research&Practice Innovation Program of Jiangsu Province(SJCX22-1819).
文摘Cellular senescence and its senescence-associated secretory phenotype(SASP)represent a pivotal role in the development of skeletal diseases.Targeted elimination or rejuvenation of senescent cells has shown potential as a therapeutic strategy to reverse age-related skeletal senescence and promote bone regeneration.Meanwhile,other age-related mechanisms,involving altered cellular functions,impaired intercellular crosstalk,disturbed tissue microenvironment,and decreased regenerative capacity,synergistically contribute to the pathogenesis.In this review,we outline the cellular senescence and other age-related mechanisms in developing skeletal diseases,including osteoporosis,intervertebral disc degeneration,osteoarthritis,rheumatoid arthritis,bone tumors and ankylosing spondylitis,with the aim of comprehensively understanding their detrimental effects on the aged skeleton and screening the potential targets for anti-aging therapy within the skeletal system.
基金supported by the National Natural Science Foundation of China(No.52470174)the Joint Research Project on Ecological Protection and High-Quality Development in the Yellow River Basin,China(No.2022-YRUC-01-050209-01).
文摘Soil microbial communities and grassland ecosystem processes are increasingly confronted with multiple global change factors(GCFs).There is still a lack of research on how these multiple GCFs interact and impact soil microbial communities and their functions.To address this gap,we conducted a simulation experiment to examine the individual and interactive effects of the four most critical and prevalent GCFs,elevated carbon dioxide concentration(eCO_(2)),elevated temperature(eT),decreased precipitation(dP),and elevated nitrogen(N)deposition(eN).This study focused on their effects on soil physicochemical properties,bacterial and fungal communities,and extracellular enzyme activities(EEAs)related to carbon(C),N,and phosphorus(P)cycles in a temperate grassland.Results showed that eCO_(2),eN,and dP tended to increase EEAs,while having neutral effects on microbial diversity and community composition.On the other hand,eT resulted in decreases in soil pH,total C,total N,EEAs,and microbial diversity,but increases in plant biomass,total P,microbial richness,and network complexity and stability.This shift in the nutrient limitation from P to N under warming conditions resulted in decoupling of nutrients.Neutral or slightly negative relationships were found between enzyme activities and microbial richness,diversity,and dominant species,and the responses of microbial communities and ecological functions were asynchronous under GCFs.Importantly,our results revealed significant higher-order interactions among GCFs and found that they had notable effects on soil physicochemical properties as well as on microbial communities and ecological functions.These findings provide valuable insights and suggestions for ecological adaptations to future global changes.
基金supported by the National Natural Science Foundation of China(No.42077192)the National Key Basic Research&Development Program of China(No.2020YFA0607802).
文摘In the context of the prevalent winter air quality issues in China marked by declining PM_(2.5)and rising O_(3),this study employed amodified WRF-Chem model to examine the aerosol radiation interaction(ARI),heterogeneous chemistry(AHC),and their combined impact(ALL)on the variations in O_(3)and PM_(2.5)during the 2014–2020 in eastern China.Our analysis confirmed that ARI curtailed O_(3)while elevating PM_(2.5).AHC reduced O_(3)through heterogeneous absorption of NOx and hydroxideswhile notably fostering fine-grained sulfate,resulting in a PM_(2.5)increase.Emission reductions mitigated the inhibitory impact of ARI on meteorological fields and photolysis rates.Emission reduction individually without aerosol feedback led to a 5.43 ppb O_(3)increase and a 22.89μg/m^(3)PM_(2.5)decrease.ARI and AHC amplified the emission-reduction-induced(ERI)O_(3)rise by 1.83 and 0.31 ppb,respectively.The response of ARI to emission diminution brought about a modest PM_(2.5)increase of 0.31μg/m^(3).Conversely,AHC,acting as the primary contributor,caused a noteworthy PM_(2.5)decrease of 4.60μg/m^(3).As efforts concentrate on reducing PM_(2.5),the promotion of ARI on PM_(2.5)counterbalanced the efficacy of emission reduction and the AHC-induced strengthening of PM_(2.5)decrease.The ALL magnified the ERI O_(3)increase by 38.9%and PM_(2.5)decrease by 18.7%.Sensitivity experiments with different degrees of emission reduction demonstrated a consistent linear relationship between the ALL-induced enhancement of O_(3)increase and PM_(2.5)decrease to the ERI PM_(2.5)decline.Our investigation revealed the complex connection between emissions and aerosol feedback in influencing air quality.
基金supported by the International Joint Research Project of Huiyan International College,Faculty of Education,Beijing Normal University(Grant Number:ICER202102).
文摘Objectives:Short video addiction has emerged as a significant public health issue in recent years,with a growing trend toward severity.However,research on the causes and impacts of short video addiction remains limited,and understanding of the variable“TikTok brain”is still in its infancy.Therefore,based on the Stimulus-Organism-Behavior-Consequence(SOBC)framework,we proposed six research hypotheses and constructed a model to explore the relationships between short video usage intensity,TikTok brain,short video addiction,and decreased attention control.Methods:Given that students are considered a high-risk group for excessive short video use,we collected 1086 valid participants from Chinese student users,including 609 males(56.1%)and 477 females(43.9%),with an average participant age of 19.84 years,to test the hypotheses.Results:(1)Short video usage intensity was positively related to short video addiction,TikTok brain,and decreased attention control;(2)TikTok brain was positively related to short video addiction and decreased attention control;and(3)Short video addiction was positively related to decreased attention control.Conclusions:These findings suggest that although excessive use of short video applications brings negative consequences,users still spend significant amounts of time on these platforms,indicating a need for strict self-regulation of usage time.
文摘The discontinuation of denosumab[antibody targeting receptor activator of nuclear factor kappa B ligand(RANKL)]therapy may increase the risk of multiple vertebral fractures;however,the underlying pathophysiology is largely unknown.In patients who underwent discontinuation after multiple injections of denosumab,the levels of tartrate-resistant acid phosphatase 5b increased compared to pretreatment levels,indicating a phenomenon known as“overshoot.”The rate of decrease in bone mineral density during the withdrawal period was higher than the rate of decrease associated with aging,suggesting that the physiological bone metabolism had broken down.Overshoot and significant bone loss were also observed in mice receiving continuous administration of anti-RANKL antibody after treatment was interrupted,resembling the original pathology.In mice long out of overshoot,bone resorption recovered,but osteoblast numbers and bone formation remained markedly reduced.The bone marrow exhibited a significant reduction in stem cell(SC)antigen 1-and platelet-derived growth factor receptor alpha-expressing osteoblast progenitors(PαS cells)and alkaline phosphatase-positive early osteoblasts.Just before the overshoot phase,the osteoclast precursor cell population expands and RANKL-bearing extracellular vesicles(EVs)became abundant in the serum,leading to robust osteoclastogenesis after cessation of anti-RANKL treatment.Thus,accelerated bone resorption due to the accumulation of RANKLbearing EVs and long-term suppression of bone formation uncoupled from bone resorption leads to the severe bone loss characteristic of denosumab discontinuation.
文摘Weight loss,whether resulting from disease-related conditions or intentional interventions,has been increasingly recognized as a significant risk factor for compromised skeletal integrity.While moderate weight reduction may yield metabolic benefits,rapid or sustained weight loss is frequently associated with decreased bone mineral density,deterioration of bone microarchitecture,and heightened fracture risk.The mechanisms underlying weight loss–induced bone loss are complex and multifactorial.Emerging evidence highlights a range of contributing factors,including reduced mechanical loading,increased bone marrow adiposity,hormonal and endocrine alterations,nutritional deficiencies,and disruptions in energy metabolism.These mechanisms are intricately interconnected,ultimately impairing bone remodeling and homeostatic balance.In this review,we provide a comprehensive analysis of the current literature on the mechanistic pathways,clinical consequences,and therapeutic strategies related to weight loss–induced bone loss.We further differentiate the skeletal effects of disease-associated versus interventioninduced weight loss,with a focus on their distinct molecular underpinnings.Our goal is to offer novel insights into the optimization of bone health management in the context of weight loss,guided by a translational medicine perspective.
基金supported by the Key Program of the National Natural Science Foundation of China(Grant No.62031013)Guangdong Province Key Construction Discipline Scientific Research Capacity Improvement Project(Grant No.2022ZDJS117).
文摘Nonlinear transforms have significantly advanced learned image compression(LIC),particularly using residual blocks.This transform enhances the nonlinear expression ability and obtain compact feature representation by enlarging the receptive field,which indicates how the convolution process extracts features in a high dimensional feature space.However,its functionality is restricted to the spatial dimension and network depth,limiting further improvements in network performance due to insufficient information interaction and representation.Crucially,the potential of high dimensional feature space in the channel dimension and the exploration of network width/resolution remain largely untapped.In this paper,we consider nonlinear transforms from the perspective of feature space,defining high-dimensional feature spaces in different dimensions and investigating the specific effects.Firstly,we introduce the dimension increasing and decreasing transforms in both channel and spatial dimensions to obtain high dimensional feature space and achieve better feature extraction.Secondly,we design a channel-spatial fusion residual transform(CSR),which incorporates multi-dimensional transforms for a more effective representation.Furthermore,we simplify the proposed fusion transform to obtain a slim architecture(CSR-sm),balancing network complexity and compression performance.Finally,we build the overall network with stacked CSR transforms to achieve better compression and reconstruction.Experimental results demonstrate that the proposed method can achieve superior ratedistortion performance compared to the existing LIC methods and traditional codecs.Specifically,our proposed method achieves 9.38%BD-rate reduction over VVC on Kodak dataset.
基金Scholarship Award for Excellent Doctoral Student granted by Ministry of Education of Chinathe Scientific Innovation Research of College Graduates in Jiangsu Province(No.CXZZ11-0150)+1 种基金the National Natural Science Foundation of China(No.51177011)the National High Technology Research and Development Program of China(863 Program)(No.2012AA050210)
文摘In order to solve the multiple power extreme value point problem caused by system frequency splitting during wireless energy transmission at short distances a transmission model of the system is established.With the comprehensive consideration of the resonance frequency load parameters and the coupling between coils the internal factors of frequency splitting and boundary conditions are discussed.The results show that under the condition of the fixed load the higher the natural resonance frequency the easier the frequency splitting. As the frequency splitting occurs the frequency of the maximum power transfer is no longer with the natural resonance frequency which can make the system unstable and the transfer power more difficult to control. Therefore a decreasing-frequency method is proposed to avoid the system frequency splitting. And decreasing the system resonance frequency can make the system successfully withdraw the frequency splitting area at a short-distance range.Under the fixed load condition the transmission power of the system can be increased by 400% and the transmission efficiency is reduced by only 14% which greatly improves the transmission performance of the system.
基金New Century Excellent Talents in University of China (NCET-06-0879)the National Natural Science Foundation of China (50971102)+2 种基金NPU Foundation for Fundamental Research (NPU-FFR-JC200808)the Fund of the State Key Laboratory of Solidification Processing (NPU) (16-TZ-2007 and 39-QZ-2009)the Programme of Introducing Talents of Discipline to Universities (08040)
基金Supported by grants from the Italian Ministry of Education, University and Research and the University of Florence, Italy
文摘AIM： To investigate the effects of long-term albumin administration on survival, recurrence of ascites and onset of other complications. METHODS： One hundred consecutive patients admitted for first-onset ascites were randomized to receive diuretics plus human albumin 25 g/wk in the first year and 25 g every two wk thereafter （group 1） or diuretics alone （group 2）. The primary endpoint was survival without liver transplantation. Secondary endpoints were recurrence of ascites and occurrence of other complications. RESULTS： Median follow-up was 84 （2-120） mo. Albu- min-treated patients had significantly greater cumulative survival rate （Breslow test= 7.05, P= 0.0078） and lower probability of ascites recurrence （51% versus 94%, P〈0.0001）. Chronic albumin infusion resulted in a mean increase in survival of 16 mo. CONCLUSION： Long-term albumin administration after first-onset ascites significantly improves patients＇ survival and decreases the risk of ascites recurrence.
基金financially supported by the National Important and Special Project on Science and Technology(2011ZX05005-005-007HZ)the National Natural Science Foundation of China(No.41274116)
文摘In full waveform inversion （FWI）, Hessian information of the misfit function is of vital importance for accelerating the convergence of the inversion; however, it usually is not feasible to directly calculate the Hessian matrix and its inverse. Although the limited memory Broyden-Fletcher-Goldfarb-Shanno （L-BFGS） or Hessian-free inexact Newton （HFN） methods are able to use approximate Hessian information, the information they collect is limited. The two methods can be interlaced because they are able to provide Hessian information for each other; however, the performance of the hybrid iterative method is dependent on the effective switch between the two methods. We have designed a new scheme to realize the dynamic switch between the two methods based on the decrease ratio （DR） of the misfit function （objective function）, and we propose a modified hybrid iterative optimization method. In the new scheme, we compare the DR of the two methods for a given computational cost, and choose the method with a faster DR. Using these steps, the modified method always implements the most efficient method. The results of Marmousi and overthrust model testings indicate that the convergence with our modified method is significantly faster than that in the L-BFGS method with no loss of inversion quality. Moreover, our modified outperforms the enriched method by a little speedup of the convergence. It also exhibits better efficiency than the HFN method.
文摘In this paper the computer code of AUTOUGH2 is used to carry out numerical simulation study on the Wuqing geothermal reservoir for evaluating reservoir performance upon different exploitation schemes.The simulating calculation and analysis of two main cases,production without reinjection and production with reinjection,were carried out to illuminate and compare the temperature and pressure profiles with distance and time.The water level or pressure will decrease with the time of production,and the reinjection will cause the cooling effect of reinjection on the production zone.
文摘Based on the summer precipitation data from 53 stations in Liaoning Province and sea surface temperature(SST) data of Hadley Center in 1961-2009,the decadal variation of the relationship between summer precipitation and SST over Nino3 oceanic regions in the previous autumn was studied.The results showed that their correlation was decreased obviously in recent 30 years.In 1961-1974,summer rainfall could be forecasted according to the SST anomaly over Nino3 oceanic regions in the previous autumn,and there were above 25 stations with the sign accuracy of over 66.7%.However,there were only five stations with the same accuracy during 1980-2009.From 1961 to 1974,25 stations showed block distribution in the central and northeastern Liaoning,but the distribution of five stations was spotty in 1980-2009.Before the middle and latter half of the 1970s,Liaoning had more(less) summer rainfall when SST over the equatorial central and eastern Pacific was higher(lower) in the previous autumn.However,it was difficult to build indicative relationship above since 1980s.
基金Supported by Key Laboratory of Space Active Opto-Electronics Technology of Chinese Academy of Sciences(2021ZDKF4)Shanghai Science and Technology Innovation Action Plan(21S31904200,22S31903700)。
文摘Because of the low convergence accuracy of the basic Harris Hawks algorithm,which quickly falls into the local optimal,a Harris Hawks algorithm combining tuna swarm algorithm and differential mutation strategy(TDHHO)is proposed.The escape energy factor of nonlinear periodic energy decline balances the ability of global exploration and regional development.The parabolic foraging approach of the tuna swarm algorithm is introduced to enhance the global exploration ability of the algorithm and accelerate the convergence speed.The difference variation strategy is used to mutate the individual position and calculate the fitness,and the fitness of the original individual position is compared.The greedy technique is used to select the one with better fitness of the objective function,which increases the diversity of the population and improves the possibility of the algorithm jumping out of the local extreme value.The test function tests the TDHHO algorithm,and compared with other optimization algorithms,the experimental results show that the convergence speed and optimization accuracy of the improved Harris Hawks are improved.Finally,the enhanced Harris Hawks algorithm is applied to engineering optimization and wireless sensor networks(WSN)coverage optimization problems,and the feasibility of the TDHHO algorithm in practical application is further verified.
