Data on lion skull measurements taken were collected and analyzed to determine trends in trophy size as an indicator of population size, and area of origin among the concessioned hunting areas in Zambia for the period...Data on lion skull measurements taken were collected and analyzed to determine trends in trophy size as an indicator of population size, and area of origin among the concessioned hunting areas in Zambia for the period 1967-2000. A comparison of trophy quality was also made with Tanzania and Zimbabwe which were the other two key sources of lion trophies in Africa. It was assumed that a comprehensive analysis of lion trophy sizes obtained from trophy hunting would be used as an indicator of hunting pressure on lion populations in Zambia. This approach was used because trophy size is an index of abundance particularly for species such as lion which are difficult to count using conventional census methods. Record lion trophies from Safari Club International rating were also collected and assessed to compare trophy quality obtained from Zambia and those of Tanzania and Zimbabwe for the same period 1967-2000 (33 years). Results obtained suggested that Zambia’s contribution to the record trophies under Safari Club International did not decline in the intervening period 1967-2000 and could not be used as an effective indicator of lion population in Zambia. At regional level, Zambia had second highest 24%, after Tanzania 56%, while Zimbabwe was third, 20%. It was found that the size of skulls could not be used as an effective indicator of population size as the record trophies did not decline while the population was alleged to have declined on the continent. Other factors, such as genetic, low prey densities, snaring, poisoning and problem animal control needed to be investigated to determine their impact on the lion population status.展开更多
Astrocytes,a major class of glial cells,have emerged as crucial regulators of synaptic function,neuronal homeostasis,and cognitive processes(Cabral-Miranda et al.,2024).These star-shaped cells not only provide structu...Astrocytes,a major class of glial cells,have emerged as crucial regulators of synaptic function,neuronal homeostasis,and cognitive processes(Cabral-Miranda et al.,2024).These star-shaped cells not only provide structural and metabolic support to neurons but also actively participate in modulating synaptic transmission,neurovascular coupling,and inflammatory responses in the brain.展开更多
Acute lung injury(ALl)is characterized by a sudden decline in pulmonary gas exchange function due to various pathological factors,with severe cases progressing to acute respiratory distress syndrome(ARDS).ARDS affects...Acute lung injury(ALl)is characterized by a sudden decline in pulmonary gas exchange function due to various pathological factors,with severe cases progressing to acute respiratory distress syndrome(ARDS).ARDS affects approximately 3million patients annually,accounting for 10% of intensive care unit admissions[1].展开更多
With the rapidly aging human population,age-related cognitive decline and dementia are becoming increasingly prevalent worldwide.Aging is considered the main risk factor for cognitive decline and acts through alterati...With the rapidly aging human population,age-related cognitive decline and dementia are becoming increasingly prevalent worldwide.Aging is considered the main risk factor for cognitive decline and acts through alterations in the composition of the gut microbiota,microbial metabolites,and the functions of astrocytes.The microbiota–gut–brain axis has been the focus of multiple studies and is closely associated with cognitive function.This article provides a comprehensive review of the specific changes that occur in the composition of the gut microbiota and microbial metabolites in older individuals and discusses how the aging of astrocytes and reactive astrocytosis are closely related to age-related cognitive decline and neurodegenerative diseases.This article also summarizes the gut microbiota components that affect astrocyte function,mainly through the vagus nerve,immune responses,circadian rhythms,and microbial metabolites.Finally,this article summarizes the mechanism by which the gut microbiota–astrocyte axis plays a role in Alzheimer’s and Parkinson’s diseases.Our findings have revealed the critical role of the microbiota–astrocyte axis in age-related cognitive decline,aiding in a deeper understanding of potential gut microbiome-based adjuvant therapy strategies for this condition.展开更多
Increasing temperatures and severe droughts threaten forest vitality globally.Prediction of forest response to climate change requires knowledge of the spatiotemporal patterns of monthly or seasonal climatic impacts o...Increasing temperatures and severe droughts threaten forest vitality globally.Prediction of forest response to climate change requires knowledge of the spatiotemporal patterns of monthly or seasonal climatic impacts on the growth of tree species,likely driven by local climatic aridity,climate trends,edaphic conditions,and the climatic adaption of tree species.The ability of tree species to cope with changing climate and the effects of environmental variables on growth trends and growth-climate relationships across diverse bioclimatic regions are still poorly understood for many species.This study investigated radial growth trends,interannual growth variability,and growth-climate sensitivity of two dominant tree species,Pinus tabulaeformis(PT)and Pinus sylvestris var.mongolica(PS),across a broad climatic gradient with a variety of soil properties in temperate Northern China.Using a network of 83 tree ring chronologies(54 for PT and 29 for PS)from 1971 to 2010,we documented that both species maintained constant growth trends at wet sites,while both displayed rapid declines at dry sites.We reported the species-specific drivers of spatial heterogeneity in growth trends,interannual growth variability,and growth-climate relationships.Calculated climatic variables and soil properties were identified as the most critical factors affecting the growth trends and growth-climate relationships.However,climatic variables play more essential roles than soil properties in determining the spatial heterogeneity of the growth-climate relationship.Lower clay content and higher soil nutrient regimes can exacerbate the moisture-related susceptibility of tree growth.Our findings highlight that soil properties emerged as important modulating factors to predict the drought vulnerability of forests in addition to climatic variables.Considering the continued climate warmingdrying trend in the future,both pines will face a more severe growth decline and increase in drought vulnerability at drier sites with lower clayed soil or higher nutrient regimes.展开更多
Background Cognitive decline is a significant concern for stroke survivors,affecting their quality of life and increasing their burden on the healthcare system.DL-3-n butylphthalide(butylphthalide)has shown efficacy i...Background Cognitive decline is a significant concern for stroke survivors,affecting their quality of life and increasing their burden on the healthcare system.DL-3-n butylphthalide(butylphthalide)has shown efficacy in the short-term treatment of various cognitive impairments.This study evaluated the efficacy of butylphthalide in preventing cognitive decline over a 12-month period in patients with ischaemic stroke.Methods This prospective following-up study involved patients newly diagnosed with ischaemic stroke between 1 month and 6 months after stroke onset and not in the acute phase.Patients were assigned to either the butylphthalide or control group.Cognitive function was assessed using the mini-mental state examination(MMSE)at baseline and at the 12-month follow-up.Statistical analyses included t-tests,χ2 tests and multivariate regression analyses.Results Butylphthalide was negatively associated with the MMSE D-value(β=−0.122;95%CI−1.932 to−0.298;p=0.003)and the MMSE D-value percentage(β=−0.117;95%CI−0.057 to−0.011;p=0.004).A multivariate analysis indicated that butylphthalide treatment was negatively associated with both changes in orientation and language score.Additionally,the incidence of cognitive decline was significantly lower in the butylphthalide group(OR,0.612;p=0.020)than the control group.An age of≥60 years and lower educational level were identified as risk factors for lower cognitive score and cognitive decline.Conclusion This study demonstrated that butylphthalide is effective in preventing cognitive decline in patients with ischaemic stroke.These findings have significant implications for clinical practice,suggesting that butylphthalide could be incorporated into standard post-stroke care regimens to improve patient outcomes and reduce the healthcare burden.Additional multicentre double-blind trials are recommended to confirm these results in diverse populations.展开更多
1.Background When searching for the term“muscle power”on Google Scholar,about 3.7 million hits come up in 60 ms,and for the past 3 years,there were approximately 225 yearly peer-reviewed publications dealing with mu...1.Background When searching for the term“muscle power”on Google Scholar,about 3.7 million hits come up in 60 ms,and for the past 3 years,there were approximately 225 yearly peer-reviewed publications dealing with muscle power.Muscle power has been used to assess and predict athletic performance,to determine muscle rehabilitation following injury or disease,to measure functional decline as occurs in aging,and many other topics.展开更多
Rarer dementias are associated with atypical symptoms and younger onset,which result in a higher burden of care.We provide a review of the global literature on longitudinal decline in activities of daily living(ADLs)i...Rarer dementias are associated with atypical symptoms and younger onset,which result in a higher burden of care.We provide a review of the global literature on longitudinal decline in activities of daily living(ADLs)in dementias that account for less than 10%of dementia diagnoses.Published studies were identified through searches conducted in Medical Literature Analysis and Retrieval System Online(MEDLINE),Excerpta Medica Database(Embase),Excerpta Medica Care(Emcare),PsycINFO,and Cumulative Index in Nursing and Allied Health Literature(CINAHL).The search criteria included terms related to‘rarer dementias’,‘activities of daily living’and‘longitudinal or cross-sectional studies’following a predefined protocol registered.Studies were screened,and those that met the criteria were citation searched.Quality assessments were performed,and relevant data were extracted.20 articles were selected,of which 19 focused on dementias within the frontotemporal dementia/primary progressive aphasia spectrum,while one addressed posterior cortical atrophy.Four studies were cross-sectional and 16 studies were longitudinal,with a median duration of 2.2 years.The Disability Assessment for Dementia was used to measure decline in 8 of the 20 studies.The varied sequences of ADL decline reported in the literature reflect variation in diagnostic specificity between studies and within-syndrome heterogeneity.Most studies used Alzheimer’s disease staging scales to measure decline,which cannot capture variant-specific symptoms.To enhance care provision in dementia,ADL scales could be deployed postdiagnosis to aid treatment and planning.This necessitates staging scales that are variant-specific and span the disease course from diagnosis to end of life.展开更多
In January and February of 2025,China's textile and clothing exports totaled 42.88 billion US dollars,marking a 4.5%decrease compared to the same period in the previous year.The primary factors contributing to thi...In January and February of 2025,China's textile and clothing exports totaled 42.88 billion US dollars,marking a 4.5%decrease compared to the same period in the previous year.The primary factors contributing to this decline are as follows:First,China’s textile and clothing exports nearly reached USD 45 billion in January and February of 2024,setting a high base.Second,in order to avoid tariffs imposed by the United States,enterprises generally concentrated their exports at the end of last year and January this year.展开更多
Objective:As the prevalence of chronic diseases among the elderly increases year by year,chronic renal insufficiency caused by hypertension has become a hot issue of concern to society and even the world.Methods:This ...Objective:As the prevalence of chronic diseases among the elderly increases year by year,chronic renal insufficiency caused by hypertension has become a hot issue of concern to society and even the world.Methods:This article conducted a retrospective analysis of 1856 elderly people over 65 years old,with a follow-up time of 6 years.The aim is to compare the decline in estimated glomerular filtration rate(EGFR)between hypertensive and non-hypertensive populations under non-intervention conditions,and to explore the impact of blood pressure on EGFR in the elderly.Results:The incidence of hypertension among the elderly in this region is significantly higher than the national level.The EGFR value of hypertensive patients is significantly lower than that of non-hypertensive people.There is a difference in the percentage decline in EGFR between hypertensive and non-hypertensive populations under non-intervention conditions,with hypertensive patients experiencing a higher rate of EGFR decline.When blood pressure is lower than 120/80 mmHg,the EGFR decline ratio is lower compared to when blood pressure is higher than 120/80 mmHg.Conclusion:Lowering blood pressure can effectively slow down the decline of EGFR,and the prevalence of hypertension should be reduced.展开更多
In the third quarter of 2025,the orders index for textile machinery-compiled by ACIMIT's Economics Department(the Association of Italian Textile Machinery Manufacturers)-recorded a16%decrease compared to the same ...In the third quarter of 2025,the orders index for textile machinery-compiled by ACIMIT's Economics Department(the Association of Italian Textile Machinery Manufacturers)-recorded a16%decrease compared to the same period in 2024.In absolute terms,the index stood at 41.8 points(base year2021=100).The decline reflects negative performances in both the domestic and foreign markets.Specifically,on the domestic market,orders fell by 17%compared to the same quarter of the previous year,with the absolute index value reaching49.9points.展开更多
On July 18th, in the first half of 2025, Rieter recorded an order intake of CHF 355.4 million(first half of 2024: CHF 403.4 million). This corresponds to a decline of around 12% compared to the same period last year. ...On July 18th, in the first half of 2025, Rieter recorded an order intake of CHF 355.4 million(first half of 2024: CHF 403.4 million). This corresponds to a decline of around 12% compared to the same period last year. The expected broader market recovery has led to shifts in investment decisions on the part of customers due to the global trade disputes(particularly US punitive tariffs) and the geopolitical uncertainty.展开更多
Forest ecosystems are critical to ecological stability,yet their functionality is increasingly threatened by the growing frequency of drought,particularly in arid and semi-arid regions.While afforestation enhances for...Forest ecosystems are critical to ecological stability,yet their functionality is increasingly threatened by the growing frequency of drought,particularly in arid and semi-arid regions.While afforestation enhances forest cover in these areas,the capacity of planted forests to adapt to climate change is poorly understood.This study examines the drought resistance and adaptive capacity of planted and naturally growing Schrenk spruce(Picea schrenkiana Fisch.&C.A.Mey.)in the Ili River Basin,Xinjiang,China using tree-ring analysis.The results indicate that natural stands have a stronger correlation with meteorological factors than plantations.Over the past 50 years,significant growth declines occurred during 1995-1997,2007-2009,and 2012-2014,with natural forests showing a greater frequency and severity of declines compared to plantations.Planted stands demonstrated greater resistance to drought,whereas natural forests had higher resilience and recovery.Over time,natural forests have shown declining resistance to drought but increased resilience and recovery.Conversely,plantations showed declines in resistance and recovery but an increased capacity for recovery.Older natural forests are more prone to growth decline,while structurally simpler planted forests show stronger drought resistance.However,following periods of drought,natural forests demonstrated a stronger capacity for recovery.These findings provide valuable insights into the response of P.schrenkiana to climate change and offer support for the sustainable management and conservation of forest ecosystems in the Xinjiang region of China.展开更多
Global climate change has caused range shifts and population declines in various species.However,causal evidence from manipulative studies,particularly for vertebrates,remains scarce.Prolonged temperature increases,a ...Global climate change has caused range shifts and population declines in various species.However,causal evidence from manipulative studies,particularly for vertebrates,remains scarce.Prolonged temperature increases,a direct consequence of climate change,pose significant challenges to species adaptation and survival.We examined the effects of prolonged temperature increases on reproduction,physiology,and behavior adaption in the greater long-tailed hamster using semi-natural enclosures where temperature was manipulated via plastic roofs and windows,creating a greenhouse effect without affecting rainfall.We analyzed data using grouped enclosures(low temperature,LT;high temperature,HT),which showed that prolonged temperature increases led to reduced reproductivity per capita during the breeding season.In addition,prolonged temperature increases reduced night-time activity in founder hamsters during overwintering,increased burrow depth during the breeding season,and raised testicular weights in founder males during the overwintering season.Our study provides experimental evidence that prolonged temperature increases negatively impact population growth of greater long-tailed hamsters by inducing temperature stress and impairing reproductive performance,highlighting the need to address heat stress in wildlife management under climate warming.展开更多
Americans have always been proud of their democratic system. Since the end of World War Ⅱ, the United States has even used its democratic system as a template to “democratize” some other countries. However, in rece...Americans have always been proud of their democratic system. Since the end of World War Ⅱ, the United States has even used its democratic system as a template to “democratize” some other countries. However, in recent years, the domestic democratic chaos in the United States has intensified, causing widespread doubts about the American political system and its democratic model.展开更多
INTRODUCTION With the expansion of the ageing population,cognitive decline has become an increas-ingly pressing challenge.1 As life expectancy increases,its socioeconomic burden is also increasing,highlighting the urg...INTRODUCTION With the expansion of the ageing population,cognitive decline has become an increas-ingly pressing challenge.1 As life expectancy increases,its socioeconomic burden is also increasing,highlighting the urgent need for effective interventions.Numerous studies suggest that specific dietary patterns and nutritional interventions may help mitigate cognitive decline associated with ageing.展开更多
EXCERPTS FROM MAJOR CHINESE MAGAZINES A RIVER REBORN China Newsweek 27 October For decades,the Yangtze River,China’s longest waterway and a vital habitat for aquatic life,suffered severe ecological decline.Overfishin...EXCERPTS FROM MAJOR CHINESE MAGAZINES A RIVER REBORN China Newsweek 27 October For decades,the Yangtze River,China’s longest waterway and a vital habitat for aquatic life,suffered severe ecological decline.Overfishing and human activity depleted its biodiversity,and by the late 2010s,its bio-integrity index had sunk to the lowest level,with almost no fish.展开更多
A decline in tree growth has occurred in numerous regions over recent decades and is associated with enhanced water deficits driven by climate warming.This phenomenon may be more noticeable at lower latitudes with hig...A decline in tree growth has occurred in numerous regions over recent decades and is associated with enhanced water deficits driven by climate warming.This phenomenon may be more noticeable at lower latitudes with higher temperatures.However,the process by which these elevated temperatures alter growth performance is not well understood.In this study,by combining tree-ring data(including 340 increment cores)and remotely sensed vegetation index data,we investigated the long-term growth performance of Pinus sylvestris var.mongolica Litv.(Mongolian pine),an important species for afforestation in northern China,in response to environmental factors in an area of introduction(lower latitude)and its native range(higher latitude).More notable decreases in both tree-ring width index(RWI)and basal area increment at breast height coincided with lower values and larger variations in the satellite-derived vegetation index in the area of introduction.The RWI showed stronger negative correlations with temperature and positive correlations with the self-calibrating Palmer drought severity index during most months in the introduction area.These results indicate that enhanced drought stress caused by elevated temperatures in lower latitudes might be a key factor for the growth decline in Mongolian pine plantations.The negative impact of increased temperatures on tree growth through exacerbating drought stress at lower latitudes with water deficit highlights the need to reduce water stress in forest management in such areas under climate warming-driven aridification.展开更多
BACKGROUND Mild cognitive impairment(MCI)and subjective cognitive decline(SCD)are risk indicators for dementia and require ongoing management.Traditional Korean medicine(TKM)commonly employs acupuncture and herbal med...BACKGROUND Mild cognitive impairment(MCI)and subjective cognitive decline(SCD)are risk indicators for dementia and require ongoing management.Traditional Korean medicine(TKM)commonly employs acupuncture and herbal medicine for cognitive impairment;yet,clinical research on acupotomy is lacking.Although most TKM treatments occur in primary care,the research is largely hospital-based.This registry was established to systematically collect real-world data on the clinical progress,efficacy,and safety of TKM with acupotomy for patients with MCI or SCD in primary care.It is hypothesized that TKM with acupotomy improves cognitive function and is safe for these patients.AIM To establish an MCI or SCD registry of patients receiving TKM,including acupotomy,to analyze its clinical efficacy and safety.METHODS This observational registry study will be conducted across 22 medical institutions;approximately 500 participants will be recruited.Data—sociodemographic information,medication history,height,weight,vital signs,and assessment questionnaires(Montreal Cognitive Assessment-Korean,short form of Korean-Everyday Cognition,Numeric Rating Scale,Korean version of the Insomnia Severity Index)—will be collected at 3-month intervals over a year.This study will also document the TKM treatment administered and any adverse events.Routine TKM procedures will be followed,with acupuncture and acupotomy administered as per protocol;treatments including herbal medicine,Chuna therapy,and moxibustion may be administered at the practitioner’s discretion.RESULTS The registry will capture a wide range of real-world clinical data regarding demographic profiles,treatment processes,and adverse events.This detailed documentation is expected to clarify patient characteristics,evaluate the clinical course,and identify factors that may affect cognitive improvement in patients with MCI and SCD.CONCLUSION This research may provide evidence supporting acupotomy for cognitive impairment in primary care by confirming its efficacy and safety,providing preliminary evidence for TKM-based interventions aimed at improving cognitive function.展开更多
文摘Data on lion skull measurements taken were collected and analyzed to determine trends in trophy size as an indicator of population size, and area of origin among the concessioned hunting areas in Zambia for the period 1967-2000. A comparison of trophy quality was also made with Tanzania and Zimbabwe which were the other two key sources of lion trophies in Africa. It was assumed that a comprehensive analysis of lion trophy sizes obtained from trophy hunting would be used as an indicator of hunting pressure on lion populations in Zambia. This approach was used because trophy size is an index of abundance particularly for species such as lion which are difficult to count using conventional census methods. Record lion trophies from Safari Club International rating were also collected and assessed to compare trophy quality obtained from Zambia and those of Tanzania and Zimbabwe for the same period 1967-2000 (33 years). Results obtained suggested that Zambia’s contribution to the record trophies under Safari Club International did not decline in the intervening period 1967-2000 and could not be used as an effective indicator of lion population in Zambia. At regional level, Zambia had second highest 24%, after Tanzania 56%, while Zimbabwe was third, 20%. It was found that the size of skulls could not be used as an effective indicator of population size as the record trophies did not decline while the population was alleged to have declined on the continent. Other factors, such as genetic, low prey densities, snaring, poisoning and problem animal control needed to be investigated to determine their impact on the lion population status.
文摘Astrocytes,a major class of glial cells,have emerged as crucial regulators of synaptic function,neuronal homeostasis,and cognitive processes(Cabral-Miranda et al.,2024).These star-shaped cells not only provide structural and metabolic support to neurons but also actively participate in modulating synaptic transmission,neurovascular coupling,and inflammatory responses in the brain.
基金supported by the National Natural Science Foun-dation of China(81970011,81970070,82100086,and 82270390)the Natural Science Foundation of Hubei Province(2025AFC006)+2 种基金the research fund from Medical Sci-Tech Innovation Platform of Zhongnan Hospital,Wuhan University(PTXM2025032)the Basic Medicine-Clinical Medicine Transformation Collaborative Fund of Zhongnan Hospital of Wuhan University,the Hubei Province Inno-vation Platform Construction Project(20204201117303072238)the Hubei Provincial Engineering Research Center of Model Animal.
文摘Acute lung injury(ALl)is characterized by a sudden decline in pulmonary gas exchange function due to various pathological factors,with severe cases progressing to acute respiratory distress syndrome(ARDS).ARDS affects approximately 3million patients annually,accounting for 10% of intensive care unit admissions[1].
基金supported by the Haihe Laboratory of Cell Ecosystem Innovation Foundation,No.22HHXBSS00047(to PL)Graduate Science and Technology Innovation Project of Tianjin,No.2022BKY173(to LZ)Tianjin Municipal Science and Technology Bureau Foundation,No.20201194(to PL).
文摘With the rapidly aging human population,age-related cognitive decline and dementia are becoming increasingly prevalent worldwide.Aging is considered the main risk factor for cognitive decline and acts through alterations in the composition of the gut microbiota,microbial metabolites,and the functions of astrocytes.The microbiota–gut–brain axis has been the focus of multiple studies and is closely associated with cognitive function.This article provides a comprehensive review of the specific changes that occur in the composition of the gut microbiota and microbial metabolites in older individuals and discusses how the aging of astrocytes and reactive astrocytosis are closely related to age-related cognitive decline and neurodegenerative diseases.This article also summarizes the gut microbiota components that affect astrocyte function,mainly through the vagus nerve,immune responses,circadian rhythms,and microbial metabolites.Finally,this article summarizes the mechanism by which the gut microbiota–astrocyte axis plays a role in Alzheimer’s and Parkinson’s diseases.Our findings have revealed the critical role of the microbiota–astrocyte axis in age-related cognitive decline,aiding in a deeper understanding of potential gut microbiome-based adjuvant therapy strategies for this condition.
基金funded by the National Key Research and Development Plan of China(No.2022YFE0127900)the National Natural Science Foundation of China(Nos.32071558,32171559)+2 种基金the Natural Science Foundation Key Project of Inner Mongolia Autonomous Region,China(No.2023ZD23)the Hulunbuir Science and Technology Plan Project(No.SF2022001)the Fundamental Research Funds of CAF(CAFYBB2023ZA002).
文摘Increasing temperatures and severe droughts threaten forest vitality globally.Prediction of forest response to climate change requires knowledge of the spatiotemporal patterns of monthly or seasonal climatic impacts on the growth of tree species,likely driven by local climatic aridity,climate trends,edaphic conditions,and the climatic adaption of tree species.The ability of tree species to cope with changing climate and the effects of environmental variables on growth trends and growth-climate relationships across diverse bioclimatic regions are still poorly understood for many species.This study investigated radial growth trends,interannual growth variability,and growth-climate sensitivity of two dominant tree species,Pinus tabulaeformis(PT)and Pinus sylvestris var.mongolica(PS),across a broad climatic gradient with a variety of soil properties in temperate Northern China.Using a network of 83 tree ring chronologies(54 for PT and 29 for PS)from 1971 to 2010,we documented that both species maintained constant growth trends at wet sites,while both displayed rapid declines at dry sites.We reported the species-specific drivers of spatial heterogeneity in growth trends,interannual growth variability,and growth-climate relationships.Calculated climatic variables and soil properties were identified as the most critical factors affecting the growth trends and growth-climate relationships.However,climatic variables play more essential roles than soil properties in determining the spatial heterogeneity of the growth-climate relationship.Lower clay content and higher soil nutrient regimes can exacerbate the moisture-related susceptibility of tree growth.Our findings highlight that soil properties emerged as important modulating factors to predict the drought vulnerability of forests in addition to climatic variables.Considering the continued climate warmingdrying trend in the future,both pines will face a more severe growth decline and increase in drought vulnerability at drier sites with lower clayed soil or higher nutrient regimes.
基金funded by Tianjin Municipal Health Commission(TJWJ2023QN115)。
文摘Background Cognitive decline is a significant concern for stroke survivors,affecting their quality of life and increasing their burden on the healthcare system.DL-3-n butylphthalide(butylphthalide)has shown efficacy in the short-term treatment of various cognitive impairments.This study evaluated the efficacy of butylphthalide in preventing cognitive decline over a 12-month period in patients with ischaemic stroke.Methods This prospective following-up study involved patients newly diagnosed with ischaemic stroke between 1 month and 6 months after stroke onset and not in the acute phase.Patients were assigned to either the butylphthalide or control group.Cognitive function was assessed using the mini-mental state examination(MMSE)at baseline and at the 12-month follow-up.Statistical analyses included t-tests,χ2 tests and multivariate regression analyses.Results Butylphthalide was negatively associated with the MMSE D-value(β=−0.122;95%CI−1.932 to−0.298;p=0.003)and the MMSE D-value percentage(β=−0.117;95%CI−0.057 to−0.011;p=0.004).A multivariate analysis indicated that butylphthalide treatment was negatively associated with both changes in orientation and language score.Additionally,the incidence of cognitive decline was significantly lower in the butylphthalide group(OR,0.612;p=0.020)than the control group.An age of≥60 years and lower educational level were identified as risk factors for lower cognitive score and cognitive decline.Conclusion This study demonstrated that butylphthalide is effective in preventing cognitive decline in patients with ischaemic stroke.These findings have significant implications for clinical practice,suggesting that butylphthalide could be incorporated into standard post-stroke care regimens to improve patient outcomes and reduce the healthcare burden.Additional multicentre double-blind trials are recommended to confirm these results in diverse populations.
文摘1.Background When searching for the term“muscle power”on Google Scholar,about 3.7 million hits come up in 60 ms,and for the past 3 years,there were approximately 225 yearly peer-reviewed publications dealing with muscle power.Muscle power has been used to assess and predict athletic performance,to determine muscle rehabilitation following injury or disease,to measure functional decline as occurs in aging,and many other topics.
基金supported by UKResearch and Innovation(MR/S03546X/1)National BrainAppeal,Economic and Social ResearchCouncil(ES/S010467/1)+4 种基金Wellcome Trust(221915/Z/20/Z),ESRC(ES/W006014/1)Royal National Institute for Deaf People-Dunhill Medical Trust Pauline Ashley(204841/Z/16/Z,PA23)London Hospitals Biomedical Research Centre(221915/Z/20/Z)Bloomsbury and East London Doctoral Training Partnership(ES/P000592/1)National Institute for Health Research.
文摘Rarer dementias are associated with atypical symptoms and younger onset,which result in a higher burden of care.We provide a review of the global literature on longitudinal decline in activities of daily living(ADLs)in dementias that account for less than 10%of dementia diagnoses.Published studies were identified through searches conducted in Medical Literature Analysis and Retrieval System Online(MEDLINE),Excerpta Medica Database(Embase),Excerpta Medica Care(Emcare),PsycINFO,and Cumulative Index in Nursing and Allied Health Literature(CINAHL).The search criteria included terms related to‘rarer dementias’,‘activities of daily living’and‘longitudinal or cross-sectional studies’following a predefined protocol registered.Studies were screened,and those that met the criteria were citation searched.Quality assessments were performed,and relevant data were extracted.20 articles were selected,of which 19 focused on dementias within the frontotemporal dementia/primary progressive aphasia spectrum,while one addressed posterior cortical atrophy.Four studies were cross-sectional and 16 studies were longitudinal,with a median duration of 2.2 years.The Disability Assessment for Dementia was used to measure decline in 8 of the 20 studies.The varied sequences of ADL decline reported in the literature reflect variation in diagnostic specificity between studies and within-syndrome heterogeneity.Most studies used Alzheimer’s disease staging scales to measure decline,which cannot capture variant-specific symptoms.To enhance care provision in dementia,ADL scales could be deployed postdiagnosis to aid treatment and planning.This necessitates staging scales that are variant-specific and span the disease course from diagnosis to end of life.
文摘In January and February of 2025,China's textile and clothing exports totaled 42.88 billion US dollars,marking a 4.5%decrease compared to the same period in the previous year.The primary factors contributing to this decline are as follows:First,China’s textile and clothing exports nearly reached USD 45 billion in January and February of 2024,setting a high base.Second,in order to avoid tariffs imposed by the United States,enterprises generally concentrated their exports at the end of last year and January this year.
基金“Clinical Research on Chronic Disease Screening and Therapeutic Guidance for Elderly People Over 60 Years Old”Kunming Science and Technology Plan Project(Project No.:2017-1-S-15382)。
文摘Objective:As the prevalence of chronic diseases among the elderly increases year by year,chronic renal insufficiency caused by hypertension has become a hot issue of concern to society and even the world.Methods:This article conducted a retrospective analysis of 1856 elderly people over 65 years old,with a follow-up time of 6 years.The aim is to compare the decline in estimated glomerular filtration rate(EGFR)between hypertensive and non-hypertensive populations under non-intervention conditions,and to explore the impact of blood pressure on EGFR in the elderly.Results:The incidence of hypertension among the elderly in this region is significantly higher than the national level.The EGFR value of hypertensive patients is significantly lower than that of non-hypertensive people.There is a difference in the percentage decline in EGFR between hypertensive and non-hypertensive populations under non-intervention conditions,with hypertensive patients experiencing a higher rate of EGFR decline.When blood pressure is lower than 120/80 mmHg,the EGFR decline ratio is lower compared to when blood pressure is higher than 120/80 mmHg.Conclusion:Lowering blood pressure can effectively slow down the decline of EGFR,and the prevalence of hypertension should be reduced.
文摘In the third quarter of 2025,the orders index for textile machinery-compiled by ACIMIT's Economics Department(the Association of Italian Textile Machinery Manufacturers)-recorded a16%decrease compared to the same period in 2024.In absolute terms,the index stood at 41.8 points(base year2021=100).The decline reflects negative performances in both the domestic and foreign markets.Specifically,on the domestic market,orders fell by 17%compared to the same quarter of the previous year,with the absolute index value reaching49.9points.
文摘On July 18th, in the first half of 2025, Rieter recorded an order intake of CHF 355.4 million(first half of 2024: CHF 403.4 million). This corresponds to a decline of around 12% compared to the same period last year. The expected broader market recovery has led to shifts in investment decisions on the part of customers due to the global trade disputes(particularly US punitive tariffs) and the geopolitical uncertainty.
基金supported by the Tianshan Talent Program of Xinjiang(2022TSYCCX0003,2024TSYCCX0041)the National Natural Science Foundation of China(42375054)+1 种基金the Desert Meteorological Science Research Foundation of China(Sqj2021018)the Young Meteorological Talent Program of China Meteorological Administration and Youth Innovation Team of China Meteorological Administration(CMA2023QN08)。
文摘Forest ecosystems are critical to ecological stability,yet their functionality is increasingly threatened by the growing frequency of drought,particularly in arid and semi-arid regions.While afforestation enhances forest cover in these areas,the capacity of planted forests to adapt to climate change is poorly understood.This study examines the drought resistance and adaptive capacity of planted and naturally growing Schrenk spruce(Picea schrenkiana Fisch.&C.A.Mey.)in the Ili River Basin,Xinjiang,China using tree-ring analysis.The results indicate that natural stands have a stronger correlation with meteorological factors than plantations.Over the past 50 years,significant growth declines occurred during 1995-1997,2007-2009,and 2012-2014,with natural forests showing a greater frequency and severity of declines compared to plantations.Planted stands demonstrated greater resistance to drought,whereas natural forests had higher resilience and recovery.Over time,natural forests have shown declining resistance to drought but increased resilience and recovery.Conversely,plantations showed declines in resistance and recovery but an increased capacity for recovery.Older natural forests are more prone to growth decline,while structurally simpler planted forests show stronger drought resistance.However,following periods of drought,natural forests demonstrated a stronger capacity for recovery.These findings provide valuable insights into the response of P.schrenkiana to climate change and offer support for the sustainable management and conservation of forest ecosystems in the Xinjiang region of China.
基金supported by the following grants:Major Program of the National Natural Science Foundation of China(Grant 32090021)Young Scientists Fund of the National Natural Science Foundation of China(Grant 32101259)+1 种基金Young Elite Scientists Sponsorship Program by CAST and ISZS(2020-2022QNRC001,ISZS-YESS Program)Chinese Academy of Science projects(Grant ANSO-CR-KP-2020-08).
文摘Global climate change has caused range shifts and population declines in various species.However,causal evidence from manipulative studies,particularly for vertebrates,remains scarce.Prolonged temperature increases,a direct consequence of climate change,pose significant challenges to species adaptation and survival.We examined the effects of prolonged temperature increases on reproduction,physiology,and behavior adaption in the greater long-tailed hamster using semi-natural enclosures where temperature was manipulated via plastic roofs and windows,creating a greenhouse effect without affecting rainfall.We analyzed data using grouped enclosures(low temperature,LT;high temperature,HT),which showed that prolonged temperature increases led to reduced reproductivity per capita during the breeding season.In addition,prolonged temperature increases reduced night-time activity in founder hamsters during overwintering,increased burrow depth during the breeding season,and raised testicular weights in founder males during the overwintering season.Our study provides experimental evidence that prolonged temperature increases negatively impact population growth of greater long-tailed hamsters by inducing temperature stress and impairing reproductive performance,highlighting the need to address heat stress in wildlife management under climate warming.
文摘Americans have always been proud of their democratic system. Since the end of World War Ⅱ, the United States has even used its democratic system as a template to “democratize” some other countries. However, in recent years, the domestic democratic chaos in the United States has intensified, causing widespread doubts about the American political system and its democratic model.
基金supported by the Shandong Second Medical University Overseas Visiting Scholar Programthe National Medical Research Council of Singapore (grant numbers NMRC/TA/0053/2016 and NMRC/CSA/INV/0009/2022)
文摘INTRODUCTION With the expansion of the ageing population,cognitive decline has become an increas-ingly pressing challenge.1 As life expectancy increases,its socioeconomic burden is also increasing,highlighting the urgent need for effective interventions.Numerous studies suggest that specific dietary patterns and nutritional interventions may help mitigate cognitive decline associated with ageing.
文摘EXCERPTS FROM MAJOR CHINESE MAGAZINES A RIVER REBORN China Newsweek 27 October For decades,the Yangtze River,China’s longest waterway and a vital habitat for aquatic life,suffered severe ecological decline.Overfishing and human activity depleted its biodiversity,and by the late 2010s,its bio-integrity index had sunk to the lowest level,with almost no fish.
基金supported by the National Natural Science Foundation of China(grants number 32220103010,32192431,31722013,32101587,32271571)the National Key R&D Program of China(2020YFA0608100)+1 种基金the Major Program of Institute of Applied Ecology,Chinese Academy of Sciences(IAEMP202201)Liaoning Provincial Science and Technology Major Project(2023JH1/10400001).
文摘A decline in tree growth has occurred in numerous regions over recent decades and is associated with enhanced water deficits driven by climate warming.This phenomenon may be more noticeable at lower latitudes with higher temperatures.However,the process by which these elevated temperatures alter growth performance is not well understood.In this study,by combining tree-ring data(including 340 increment cores)and remotely sensed vegetation index data,we investigated the long-term growth performance of Pinus sylvestris var.mongolica Litv.(Mongolian pine),an important species for afforestation in northern China,in response to environmental factors in an area of introduction(lower latitude)and its native range(higher latitude).More notable decreases in both tree-ring width index(RWI)and basal area increment at breast height coincided with lower values and larger variations in the satellite-derived vegetation index in the area of introduction.The RWI showed stronger negative correlations with temperature and positive correlations with the self-calibrating Palmer drought severity index during most months in the introduction area.These results indicate that enhanced drought stress caused by elevated temperatures in lower latitudes might be a key factor for the growth decline in Mongolian pine plantations.The negative impact of increased temperatures on tree growth through exacerbating drought stress at lower latitudes with water deficit highlights the need to reduce water stress in forest management in such areas under climate warming-driven aridification.
基金Supported by The Korea Health Technology Project through the Korea Health Industry Development Institute,funded by the Ministry of Health and Welfare,Republic of Korea,No.RS-2023-KH138802.
文摘BACKGROUND Mild cognitive impairment(MCI)and subjective cognitive decline(SCD)are risk indicators for dementia and require ongoing management.Traditional Korean medicine(TKM)commonly employs acupuncture and herbal medicine for cognitive impairment;yet,clinical research on acupotomy is lacking.Although most TKM treatments occur in primary care,the research is largely hospital-based.This registry was established to systematically collect real-world data on the clinical progress,efficacy,and safety of TKM with acupotomy for patients with MCI or SCD in primary care.It is hypothesized that TKM with acupotomy improves cognitive function and is safe for these patients.AIM To establish an MCI or SCD registry of patients receiving TKM,including acupotomy,to analyze its clinical efficacy and safety.METHODS This observational registry study will be conducted across 22 medical institutions;approximately 500 participants will be recruited.Data—sociodemographic information,medication history,height,weight,vital signs,and assessment questionnaires(Montreal Cognitive Assessment-Korean,short form of Korean-Everyday Cognition,Numeric Rating Scale,Korean version of the Insomnia Severity Index)—will be collected at 3-month intervals over a year.This study will also document the TKM treatment administered and any adverse events.Routine TKM procedures will be followed,with acupuncture and acupotomy administered as per protocol;treatments including herbal medicine,Chuna therapy,and moxibustion may be administered at the practitioner’s discretion.RESULTS The registry will capture a wide range of real-world clinical data regarding demographic profiles,treatment processes,and adverse events.This detailed documentation is expected to clarify patient characteristics,evaluate the clinical course,and identify factors that may affect cognitive improvement in patients with MCI and SCD.CONCLUSION This research may provide evidence supporting acupotomy for cognitive impairment in primary care by confirming its efficacy and safety,providing preliminary evidence for TKM-based interventions aimed at improving cognitive function.
