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Recent Progress on Data-Based Optimization for MineralProcessing Plants 被引量:9
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作者 Jinliang Ding Cuie Yang Tianyou Chai 《Engineering》 SCIE EI 2017年第2期183-187,共5页
In the globalized market environment, increasingly significant economic and environmental factors withincomplex industrial plants impose importance on the optimization of global production indices; such opti-mization ... In the globalized market environment, increasingly significant economic and environmental factors withincomplex industrial plants impose importance on the optimization of global production indices; such opti-mization includes improvements in production efficiency, product quality, and yield, along with reductionsof energy and resource usage. This paper briefly overviews recent progress in data-driven hybrid intelli-gence optimization methods and technologies in improving the performance of global production indicesin mineral processing. First, we provide the problem description. Next, we summarize recent progress indata-based optimization for mineral processing plants. This optimization consists of four layers: optimiza-tion of the target values for monthly global production indices, optimization of the target values for dailyglobal production indices, optimization of the target values for operational indices, and automation systemsfor unit processes. We briefly overview recent progress in each of the different layers. Finally, we point outopportunities for future works in data-based optimization for mineral processing plants. 展开更多
关键词 data-based OPTIMIZATION Plant-wide GLOBAL OPTIMIZATION MINERAL processing SURVEY
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Data-based Fault Tolerant Control for Affine Nonlinear Systems Through Particle Swarm Optimized Neural Networks 被引量:18
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作者 Haowei Lin Bo Zhao +1 位作者 Derong Liu Cesare Alippi 《IEEE/CAA Journal of Automatica Sinica》 SCIE EI CSCD 2020年第4期954-964,共11页
In this paper, a data-based fault tolerant control(FTC) scheme is investigated for unknown continuous-time(CT)affine nonlinear systems with actuator faults. First, a neural network(NN) identifier based on particle swa... In this paper, a data-based fault tolerant control(FTC) scheme is investigated for unknown continuous-time(CT)affine nonlinear systems with actuator faults. First, a neural network(NN) identifier based on particle swarm optimization(PSO) is constructed to model the unknown system dynamics. By utilizing the estimated system states, the particle swarm optimized critic neural network(PSOCNN) is employed to solve the Hamilton-Jacobi-Bellman equation(HJBE) more efficiently.Then, a data-based FTC scheme, which consists of the NN identifier and the fault compensator, is proposed to achieve actuator fault tolerance. The stability of the closed-loop system under actuator faults is guaranteed by the Lyapunov stability theorem. Finally, simulations are provided to demonstrate the effectiveness of the developed method. 展开更多
关键词 Adaptive dynamic programming(ADP) critic neural network data-based fault tolerant control(FTC) particle swarm optimization(PSO)
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Data-Based Optimal Tracking of Autonomous Nonlinear Switching Systems 被引量:3
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作者 Xiaofeng Li Lu Dong Changyin Sun 《IEEE/CAA Journal of Automatica Sinica》 SCIE EI CSCD 2021年第1期227-238,共12页
In this paper,a data-based scheme is proposed to solve the optimal tracking problem of autonomous nonlinear switching systems.The system state is forced to track the reference signal by minimizing the performance func... In this paper,a data-based scheme is proposed to solve the optimal tracking problem of autonomous nonlinear switching systems.The system state is forced to track the reference signal by minimizing the performance function.First,the problem is transformed to solve the corresponding Bellman optimality equation in terms of the Q-function(also named as action value function).Then,an iterative algorithm based on adaptive dynamic programming(ADP)is developed to find the optimal solution which is totally based on sampled data.The linear-in-parameter(LIP)neural network is taken as the value function approximator.Considering the presence of approximation error at each iteration step,the generated approximated value function sequence is proved to be boundedness around the exact optimal solution under some verifiable assumptions.Moreover,the effect that the learning process will be terminated after a finite number of iterations is investigated in this paper.A sufficient condition for asymptotically stability of the tracking error is derived.Finally,the effectiveness of the algorithm is demonstrated with three simulation examples. 展开更多
关键词 Adaptive dynamic programming approximation error data-based control Q-LEARNING switching system
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Data-Based Filters for Non-Gaussian Dynamic Systems With Unknown Output Noise Covariance 被引量:1
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作者 Elham Javanfar Mehdi Rahmani 《IEEE/CAA Journal of Automatica Sinica》 SCIE EI CSCD 2024年第4期866-877,共12页
This paper proposes linear and nonlinear filters for a non-Gaussian dynamic system with an unknown nominal covariance of the output noise.The challenge of designing a suitable filter in the presence of an unknown cova... This paper proposes linear and nonlinear filters for a non-Gaussian dynamic system with an unknown nominal covariance of the output noise.The challenge of designing a suitable filter in the presence of an unknown covariance matrix is addressed by focusing on the output data set of the system.Considering that data generated from a Gaussian distribution exhibit ellipsoidal scattering,we first propose the weighted sum of norms(SON)clustering method that prioritizes nearby points,reduces distant point influence,and lowers computational cost.Then,by introducing the weighted maximum likelihood,we propose a semi-definite program(SDP)to detect outliers and reduce their impacts on each cluster.Detecting these weights paves the way to obtain an appropriate covariance of the output noise.Next,two filtering approaches are presented:a cluster-based robust linear filter using the maximum a posterior(MAP)estimation and a clusterbased robust nonlinear filter assuming that output noise distribution stems from some Gaussian noise resources according to the ellipsoidal clusters.At last,simulation results demonstrate the effectiveness of our proposed filtering approaches. 展开更多
关键词 data-based filter maximum likelihood estimation unknown covariance weighted maximum likelihood estimation weighted sum-of-norms clustering
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Linked Data-based Slide Repository: The Episodic Slide Retrieval Using the Episodic Keyword Networks
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作者 Tomohiro Iwasa Yudai Kato +2 位作者 Shun Shiramatsu Tadaehika Ozono Toramatsu Shintani 《Journal of Control Science and Engineering》 2016年第1期36-49,共14页
This paper focuses on developing a system that allows presentation authors to effectively retrieve presentation slides for reuse from a large volume of existing presentation materials. We assume episodic memories of t... This paper focuses on developing a system that allows presentation authors to effectively retrieve presentation slides for reuse from a large volume of existing presentation materials. We assume episodic memories of the authors can be used as contextual keywords in query expressions to efficiently dig out the expected slides for reuse rather than using only the part-of-slide-descriptions-based keyword queries. As a system, a new slide repository is proposed, composed of slide material collections, slide content data and pieces of information from authors' episodic memories related to each slide and presentation together with a slide retrieval application enabling authors to use the episodic memories as part of queries. The result of our experiment shows that the episodic memory-used queries can give more discoverability than the keyword-based queries. Additionally, an improvement model is discussed on the slide retrieval for further slide-finding efficiency by expanding the episodic memories model in the repository taking in the links with the author-and-slide-related data and events having been post on the private and social media sites. 展开更多
关键词 Slide Retrieval Linked data-based Slide Repository Episodic Keyword Networks Linked Data episodic memories social media life event.
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The COVID-19 and the“European Solution”of Data-based Approach to Governance:Public Security or Data Protection?
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作者 刘洋 李益斌 NIU Huizi(Translated) 《The Journal of Human Rights》 2022年第3期483-503,共21页
To cope with the challenges of CoViD-19,europe has adopted relevant measures of a data-based approach to governance,on which scholars have huge differences,and the related researches are conducive to further discussio... To cope with the challenges of CoViD-19,europe has adopted relevant measures of a data-based approach to governance,on which scholars have huge differences,and the related researches are conducive to further discussion on the differences.By sorting out the challenges posed by the pandemic to public security and data protection in europe,we can summarize the“european Solution”of the data-based approach to governance,including legislation,instruments,supervision,international cooperation,and continuity.The“Solution”has curbed the spread of the pandemic to a certain extent.However,due to the influence of the traditional values of the EU,the“Solution”is too idealistic in the balance between public security and data protection,which intensifies the dilemma and causes many problems,such as ambiguous legislation,inadequate effectiveness and security of instruments,an arduous endeavor in inter national cooperation,and imperfect regulations on digital green certificates.Therefore,in a major public health crisis,there is still a long way to go in exploring a balance between public security and data protection. 展开更多
关键词 European solution data-based approach to governance data protection public security
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Optimal Tracking Control for a Class of Unknown Discrete-time Systems with Actuator Saturation via Data-based ADP Algorithm 被引量:4
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作者 SONG Rui-Zhuo XIAO Wen-Dong SUN Chang-Yin 《自动化学报》 EI CSCD 北大核心 2013年第9期1413-1420,共8页
为有致动器浸透和未知动力学的分离时间的系统的一个班的一个新奇最佳的追踪控制方法在这份报纸被建议。计划基于反复的适应动态编程(自动数据处理)算法。以便实现控制计划,一个data-based标识符首先为未知系统动力学被构造。由介绍M网... 为有致动器浸透和未知动力学的分离时间的系统的一个班的一个新奇最佳的追踪控制方法在这份报纸被建议。计划基于反复的适应动态编程(自动数据处理)算法。以便实现控制计划,一个data-based标识符首先为未知系统动力学被构造。由介绍M网络,稳定的控制的明确的公式被完成。以便消除致动器浸透的效果,nonquadratic表演功能被介绍,然后一个反复的自动数据处理算法被建立与集中分析完成最佳的追踪控制解决方案。为实现最佳的控制方法,神经网络被用来建立data-based标识符,计算性能索引功能,近似最佳的控制政策并且分别地解决稳定的控制。模拟例子被提供验证介绍最佳的追踪的控制计划的有效性。 展开更多
关键词 最优跟踪控制 离散时间系统 饱和执行器 DP算法 控制方案 神经网络 性能指标 系统动力学
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A data-based inverse problem-solving method for predicting structural orderings
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作者 Yiwen LI Jianlong CHEN +2 位作者 Guangyan LIU Zhanli LIU Kai ZHANG 《Frontiers of Structural and Civil Engineering》 2025年第1期22-33,共12页
Inverse problem-solving methods have found applications in various fields,such as structural mechanics,acoustics,and non-destructive testing.However,accurately solving inverse problems becomes challenging when observe... Inverse problem-solving methods have found applications in various fields,such as structural mechanics,acoustics,and non-destructive testing.However,accurately solving inverse problems becomes challenging when observed data are incomplete.Fortunately,advancements in computer science have paved the way for data-based methods,enabling the discovery of nonlinear relationships within diverse data sets.In this paper,a step-by-step completion method of displacement information is introduced and a data-driven approach for predicting structural parameters is proposed.The accuracy of the proposed approach is 23.83%higher than that of the Genetic Algorithm,demonstrating the outstanding accuracy and efficiency of the data-driven approach.This work establishes a framework for solving mechanical inverse problems by leveraging a data-based method,and proposes a promising avenue for extending the application of the data-driven approach to structural health monitoring. 展开更多
关键词 mechanical inverse problem displacement information completion digital structural orderings data-based method genetic algorithm
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Data-Based Predictive Control for Networked Nonlinear Systems with Packet Dropout and Measurement Noise 被引量:12
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作者 PANG Zhonghua LIU Guoping +1 位作者 ZHOU Donghua SUN Dehui 《Journal of Systems Science & Complexity》 SCIE EI CSCD 2017年第5期1072-1083,共12页
In this paper, the data-based control problem is investigated for a class of networked nonlinear systems with measurement noise as well as packet dropouts in the feedback and forward channels. The measurement noise an... In this paper, the data-based control problem is investigated for a class of networked nonlinear systems with measurement noise as well as packet dropouts in the feedback and forward channels. The measurement noise and the number of consecutive packet dropouts in both channels are assumed to be random but bounded. A data-based networked predictive control method is proposed, in which a sequence of control increment predictions are calculated in the controller based on the measured output error, and based on the control increment predictions received by the actuator, a proper control action is obtained and applied to the plant according to the real-time number of consecutive packet dropouts at each sampling instant. Then the stability analysis is performed for the networked closedloop system. Finally, the effectiveness of the proposed method is illustrated by a numerical example. 展开更多
关键词 data-based control measurement noise networked control systems (NCSs) packet dropout predictive control
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Sampled-data-based LQ control of stochastic linear continuous-time systems 被引量:1
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作者 姚莉丽 张纪峰 《Science in China(Series F)》 2002年第5期383-396,共14页
Sampled-data (SD) based linear quadratic (LQ) control problem of stochastic linear continuous-time (LCT) systems is discussed. Two types of systems are involved. One is time-invariant and the other is time-varying. In... Sampled-data (SD) based linear quadratic (LQ) control problem of stochastic linear continuous-time (LCT) systems is discussed. Two types of systems are involved. One is time-invariant and the other is time-varying. In addition to stability analysis of the closed-loop systems, the index difference between SD-based LQ control and conventional LQ control is investigated. It is shown that when sample time ?T is small, so is the index difference. In addition, the upper bounds of the differences are also presented, which are O(?T2) and O(?T), respectively. 展开更多
关键词 stochastic system sampled-data-based control time-varying parameter LQ index.
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Data-based intelligent modeling and control for nonlinear systems
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作者 Chaoxu MU Changyin SUN 《Frontiers of Electrical and Electronic Engineering in China》 CSCD 2011年第2期291-299,共9页
With the ever increasing complexity of industrial systems,model-based control has encountered difficulties and is facing problems,while the interest in data-based control has been booming.This paper gives an overview ... With the ever increasing complexity of industrial systems,model-based control has encountered difficulties and is facing problems,while the interest in data-based control has been booming.This paper gives an overview of data-based control,which divides it into two subfields,intelligent modeling and direct controller design.In the two subfields,some important methods concerning data-based control are intensively investigated.Within the framework of data-based modeling,main modeling technologies and control strategies are discussed,and then fundamental concepts and various algorithms are presented for the design of a data-based controller.Finally,some remaining challenges are suggested. 展开更多
关键词 offline and online data intelligent modeling data-based control PERSPECTIVE
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外篇:日本的漫画发展逻辑——日本同人志、Data-base消费论对独立漫画的启示
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作者 张彧暋 《明日风尚》 2012年第1期173-173,共1页
在漫画市场极度发达的日本,与动漫画相关的书本大致分为两类,一种是"商业志",就是一般在市场流通、在书店能够买得到的、通常有国际书号的出版物,另一种是"同人志",泛指一些同好们按照版权原作,进行二次创作,自费出... 在漫画市场极度发达的日本,与动漫画相关的书本大致分为两类,一种是"商业志",就是一般在市场流通、在书店能够买得到的、通常有国际书号的出版物,另一种是"同人志",泛指一些同好们按照版权原作,进行二次创作,自费出版,在同人志贩卖会交易的作品。因此,日本的分类与概念,重点不在销售量以及销售量决定的主流或非主流,反而是销售渠道;无关"商业市场逻辑"与"独立文化"的对立,反而是消费模式的变迁。在日本语境,"独立漫画"勉强可翻译成"次文化漫画"(sabu-karu komikkuサブカルミック),其实也是商业出版。所以备受漫画学者关注的是第二种现象,同人志的出现。 展开更多
关键词 data-base 商业志 二次创作 外篇 销售渠道 消费模式 发展逻辑 东浩 市场逻辑 交换活动
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Dynamic prediction of building subsidence deformation with data-based mechanistic self-memory model 被引量:5
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作者 WANG Wei SU JingYu +2 位作者 HOU BenWei TIAN Jie MA DongHui 《Chinese Science Bulletin》 SCIE CAS 2012年第26期3430-3435,共6页
This paper describes a building subsidence deformation prediction model with the self-memorization principle.According to the non-linear specificity and monotonic growth characteristics of the time series of building ... This paper describes a building subsidence deformation prediction model with the self-memorization principle.According to the non-linear specificity and monotonic growth characteristics of the time series of building subsidence deformation,a data-based mechanistic self-memory model considering randomness and dynamic features of building subsidence deformation is established based on the dynamic data retrieved method and the self-memorization equation.This model first deduces the differential equation of the building subsidence deformation system using the dynamic retrieved method,which treats the monitored time series data as particular solutions of the nonlinear dynamic system.Then,the differential equation is evolved into a difference-integral equation by the self-memory function to establish the self-memory model of dynamic system for predicting nonlinear building subsidence deformation.As the memory coefficients of the proposed model are calculated with historical data,which contain useful information for the prediction and overcome the shortcomings of the average prediction,the model can predict extreme values of a system and provide higher fitting precision and prediction accuracy than deterministic or random statistical prediction methods.The model was applied to subsidence deformation prediction of a building in Xi'an.It was shown that the model is valid and feasible in predicting building subsidence deformation with good accuracy. 展开更多
关键词 建筑物沉降 记忆模型 沉降变形 动态预测 机械 基础 非线性动态系统 时间序列数据
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多组学拓展骨质疏松症的新治疗靶点:亚洲、欧洲项目组数据分析
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作者 陈勇喜 《中国组织工程研究》 北大核心 2026年第24期6382-6389,共8页
背景:随着中国老龄化进程的加快,骨质疏松症患者也逐渐增多,而全基因组关联研究和单细胞转录测序的发展使得研究者们可通过将各组学研究数据相结合以发现更多与骨质疏松症相关的基因。目的:通过整合亚洲、欧洲人群的全基因组关联研究和... 背景:随着中国老龄化进程的加快,骨质疏松症患者也逐渐增多,而全基因组关联研究和单细胞转录测序的发展使得研究者们可通过将各组学研究数据相结合以发现更多与骨质疏松症相关的基因。目的:通过整合亚洲、欧洲人群的全基因组关联研究和转录组学,基于汇总统计数据的孟德尔随机化拓展骨质疏松症新的治疗靶点。方法:通过整合来自多个组织(血液、肌肉-骨骼)的顺式表达数量性状位点和蛋白质数量性状位点数据集(基因-组织表达项目组V.8选取了人类血液与骨骼-肌肉两种组织的表达数量性状位点数据集,基因-组织表达项目组是研究基因表达在不同组织/器官中变异及其与遗传调控关系的大型国际合作项目)及骨质疏松症全基因组关联研究数据(FinnGen数据库2021年发布的关于欧洲人种骨质疏松症的全基因组关联研究数据,FinnGen是芬兰的一个大型基因组研究项目);从日本生物银行数据库获取的2020年发布关于东亚人群的大规模全基因组关联研究,是日本主导的大规模人群队列研究项目,使用基于汇总统计数据的孟德尔随机化方法来鉴定骨质疏松症的相关基因,并使用共定位分析、单细胞测序及富集分析对已鉴定出的相关基因做进一步分析。所有数据均来自于已发表的研究或公开可用的数据,均已提供伦理审批书和知情同意书。结果与结论:①基于汇总统计数据的孟德尔随机化分析一共确定了64个(去除重复基因后)与骨质疏松症显著相关的基因,其中人类白细胞抗原(HLA)等位基因HLA-DQA1、HLA-DQA2、HLA-DQB1、HLA-DQB2和HLA-DRB5在2个结局数据集中得到了相互验证,具有显著相关性;②进一步的共定位分析表明,HLA-DQA2、HLA-DQB1具有共定位的证据(后验概率PPH4>0.8);③蛋白质数量性状位点分析结果表明,血浆中高水平的HLA-DQA2与骨质疏松症风险降低相关;④在单细胞测序分析方面,在骨质疏松症的免疫微环境中,树突状细胞、B细胞、巨噬细胞和中性粒细胞丰度较其他细胞群明显升高;⑤富集分析结果表明,鉴定出的基因在组织相容性复合物Ⅱ分子抗原呈递途径富集;⑥此次研究通过生物信息学结合亚洲、欧洲人群的全基因组关联数据,初步确定了几个以前尚未报道过的与骨质疏松症相关的基因,研究者们可在临床试验中进一步探索上述基因作为骨质疏松症新的治疗途径的潜力。 展开更多
关键词 全基因组关联研究 单细胞测序 骨质疏松症 基于汇总数据的孟德尔随机化
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大数据背景下研究性教学模式的探究与实践——以“食品营养学”为例
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作者 李宁 李天歌 +4 位作者 宋莲军 高晓平 李倩 乔明武 黄现青 《农产品加工》 2026年第1期135-138,共4页
探讨了大数据背景下研究性教学模式在“食品营养学”课程中的应用与实践。首先,分析了传统教学模式存在的问题,如教学理念落后、教学资源配置不足等。随后,介绍了大数据技术在教育领域的广泛应用及其对营养健康领域带来的变革,为研究性... 探讨了大数据背景下研究性教学模式在“食品营养学”课程中的应用与实践。首先,分析了传统教学模式存在的问题,如教学理念落后、教学资源配置不足等。随后,介绍了大数据技术在教育领域的广泛应用及其对营养健康领域带来的变革,为研究性教学模式的引入提供了背景支持。在“食品营养学”课程中,通过采用研究性教学模式,激发学生的学习兴趣,培养其主动学习和综合分析能力。具体实施方式包括确定研究性学习问题、学生分组选题、查阅资料、学习讨论、信息梳理、分析简答问题、撰写论文及制作PPT进行答辩等。同时,借助大数据技术,实现了对学生学习过程的精准跟踪和反馈,优化了教学效果。最后,总结了研究性教学模式在“食品营养学”课程中的实践成果,包括学生创新能力的提升、学习成绩的提高及教师教学能力的增强等。 展开更多
关键词 大数据 研究性教学 教学模式 食品营养学
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基于可信执行环境的层次角色基分级加密方案
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作者 赵佳 王妍淳 +1 位作者 马洪亮 李琪 《信息网络安全》 北大核心 2026年第2期315-324,共10页
文章提出一种基于可信执行环境的层次角色基分级加密方案,以解决现有加密技术在数据敏感性保护和运行时的安全问题。该方案结合了层次角色基加密技术和可信计算,根据数据敏感性选择不同层次的角色公钥进行加密,实现对数据访问权限和敏... 文章提出一种基于可信执行环境的层次角色基分级加密方案,以解决现有加密技术在数据敏感性保护和运行时的安全问题。该方案结合了层次角色基加密技术和可信计算,根据数据敏感性选择不同层次的角色公钥进行加密,实现对数据访问权限和敏感性要求的动态匹配。对于一般性数据,采用深层节点的角色密钥进行加密;对于高度敏感数据,使用靠近根节点的浅层节点的角色密钥进行加密。此外,该方案将加密操作和密钥管理操作置于可信执行环境中,可有效防止加密密钥和敏感数据被窃取或篡改,弥补了传统加密方案在系统运行时防护能力差的不足。同时,该方案结合可信执行环境的硬件隔离特性和层次角色基加密技术,不仅提升了系统的抗攻击能力,还实现了更精细的权限管理。实验结果表明,该方案在保证数据安全的同时具有较高的计算效率。 展开更多
关键词 数据加密 身份基加密 可信执行环境 Intel SGX
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基于中医古籍循证与数据挖掘的胸痹用药规律研究
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作者 孙敏 张华敏 +3 位作者 佟琳 张淼 曲苗 张磊 《中国中医基础医学杂志》 2026年第2期390-394,共5页
目的运用中医古籍循证评价与数据挖掘方法对古医籍中治疗胸痹的方剂进行系统评价和挖掘分析。方法对筛选后的治疗胸痹的中医古籍方药证据应用《中医古籍证据评价分级量表》进行评价及分级,对高等级证据应用“古今医案云平台”进行药物... 目的运用中医古籍循证评价与数据挖掘方法对古医籍中治疗胸痹的方剂进行系统评价和挖掘分析。方法对筛选后的治疗胸痹的中医古籍方药证据应用《中医古籍证据评价分级量表》进行评价及分级,对高等级证据应用“古今医案云平台”进行药物使用频次、功效类别、性味归经等分析,并进行关联规则分析与聚类分析。结果最终纳入155条治疗胸痹的中医古籍证据,评价得出人参汤、茯苓杏仁甘草汤、栝蒌薤白半夏汤等31个方剂为高等级证据,数据挖掘分析结果显示古籍中治疗胸痹的高等级证据中药物功效以散寒止痛、补火助阳、温通经脉为主;温性药物使用最多;药味以辛为主;药物归经以脾经为主。关联规则分析显示肉桂是治疗胸痹心痛的常用药物,“人参-肉桂”为治疗胸痹最常用的药对;聚类分析共得到4个核心组方,分别体现了不同的治疗思路。结论本研究借助中医古籍循证评价与数据挖掘方法对古医籍中治疗胸痹的方药证据进行质量评价与深度挖掘分析,所得结果不仅能为中医临床治疗胸痹提供更为可靠的古籍依据,更能为中医临床决策的制定提供充分的古籍证据支撑。 展开更多
关键词 中医古籍 循证 数据挖掘 胸痹 用药规律
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DYRK2:基于东亚和欧洲人群揭示类风湿关节炎合并骨质疏松症的治疗新靶点
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作者 吴治林 何秦 +4 位作者 王枰稀 石现 袁松 张骏 王浩 《中国组织工程研究》 北大核心 2026年第6期1569-1579,共11页
背景:研究表明,类风湿关节炎与骨质疏松症呈正相关趋势,但因果关系和相关机制仍未得到证实。随着计算机科学和生命科学的交叉融合,基于全基因组关联研究数据和转录组测序数据进行孟德尔随机化和生信分析,可以评估两疾病间的因果关系、... 背景:研究表明,类风湿关节炎与骨质疏松症呈正相关趋势,但因果关系和相关机制仍未得到证实。随着计算机科学和生命科学的交叉融合,基于全基因组关联研究数据和转录组测序数据进行孟德尔随机化和生信分析,可以评估两疾病间的因果关系、探索相关机制以及挖掘治疗靶点,这将利于类风湿关节炎合并骨质疏松症的精准治疗。目的:采用双样本孟德尔随机化分析类风湿关节炎和骨质疏松症间的因果关系,同时基于汇总数据的孟德尔随机化分析和生信分析挖掘潜在共病靶点和靶向药物,旨在为类风湿关节炎合并骨质疏松症的机制探索和精准治疗提供理论依据。方法:①从基于亚洲人群和欧洲人群的GWAS Catalog、IEU Open GWAS、FinnGen以及eQTLGen数据库下载类风湿关节炎、骨质疏松症和顺式表达数量性状位点的全基因组关联研究数据,用于双样本孟德尔随机化和基于汇总数据的孟德尔随机化分析。②从GEO数据库下载类风湿关节炎的转录组测序数据(GSE93272和GSE15573),用于生物信息学分析。③以逆方差加权法作为主要分析方法,进行类风湿关节炎和骨质疏松症之间的正向和反向双样本孟德尔随机化分析,并用MR Egger法、简单模式法、加权中位数法和加权模式法对结果加以佐证。④基于汇总数据的孟德尔随机化分析鉴定与类风湿关节炎和骨质疏松症相关的基因,并基于交叉分析挖掘出类风湿关节炎和骨质疏松症共病靶点。同时,基于生信分析和细胞实验验证共病靶点的生物学功能。⑤此外,基于DYRK2构建类风湿关节炎风险预测诺莫图,通过受试者特征曲线、矫正曲线和决策曲线验证预测性能。最后,基于Enrichr数据库挖掘靶点潜在药物并进行分子对接。结果与结论:①正向孟德尔随机化分析结果显示,除外GCST90044540和GCST90086118无统计学意义,其他所有结果均表明类风湿关节炎和骨质疏松症间存在显著因果关系,并且呈正相关。②反向孟德尔随机化分析结果提示,骨质疏松症和类风湿关节炎间未见显著因果关系。③基于汇总数据的孟德尔随机化分析共鉴定出412和344个与类风湿关节炎和骨质疏松症正相关的基因,421和347个负相关基因。基于交叉分析得到26个共病基因。其中,DYRK2是潜在治疗靶点,后续生信分析和细胞实验证实DYRK2在类风湿关节炎和骨质疏松症的进展过程中发挥重要作用。④此外,构建的诺莫图具有出色的预测性能。最后,挖掘出4个DYRK2的潜在靶向药物(Undecanoic Acid、Metyrapone、JNJ-38877605和ACA),分子对接也证明具有可靠的靶向能力。⑤总之,基于亚洲人群和欧洲人群的全基因组关联研究数据证明了类风湿关节炎和骨质疏松症在遗传学层面存在着因果关系,DYRK2是潜在治疗靶点,有4种小分子是潜在靶向药物。 展开更多
关键词 类风湿关节炎 骨质疏松症 孟德尔随机化 基于汇总数据的孟德尔随机化 共病基因 DYRK2
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知识图谱赋能项目化实验教学实践——以数据仓库课程为例
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作者 张海 陈仲委 胡浩亮 《浙江万里学院学报》 2026年第1期87-95,共9页
在“新工科”建设与大数据技术迅猛发展的背景下,传统数据仓库课程实验教学普遍存在知识碎片化、项目实践不足等问题。文章提出一种融合知识图谱与项目驱动理念的实验教学模式,通过构建课程知识图谱,实现教学任务、知识点与能力目标的... 在“新工科”建设与大数据技术迅猛发展的背景下,传统数据仓库课程实验教学普遍存在知识碎片化、项目实践不足等问题。文章提出一种融合知识图谱与项目驱动理念的实验教学模式,通过构建课程知识图谱,实现教学任务、知识点与能力目标的精准映射,并采用“验证性—综合性—实战性”递进式路径组织教学内容。浙江某学院2023级数据科学与大数据技术专业的教学实践表明,该模式显著提升了学生的知识整合能力、工程实践能力与团队协作能力,同时增强了学习主动性与创新意识,具有良好的推广与应用价值。 展开更多
关键词 知识图谱 项目化教学 实验教学 数据仓库 教学改革
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基于对接职业教育智慧大脑院校数据中台的实施路径——以重庆青年职业技术学院为例
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作者 王博 王建中 黎邦银 《现代信息科技》 2026年第2期139-144,共6页
为了实施国家教育数字化战略行动,落实职业院校对接职业教育智慧大脑院校数据中台建设要求,文章分析对接任务的10个数据子集中的98张表,梳理并制定本校数据标准,实现了数据汇聚、存储、运算、开发、服务、可视化分析、质量安全管控一体... 为了实施国家教育数字化战略行动,落实职业院校对接职业教育智慧大脑院校数据中台建设要求,文章分析对接任务的10个数据子集中的98张表,梳理并制定本校数据标准,实现了数据汇聚、存储、运算、开发、服务、可视化分析、质量安全管控一体化,利用CampusCube数据基座,方便快捷地实现了数据的全量推送和增量推送,快速高效对接职业教育数据中台,降低了开发和维护成本,为智慧校园建设提供了参考。 展开更多
关键词 数据中台 智慧大脑 数据中心 数据基座
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