Background:The present study aimed to develop a film-forming spray containing an epigallocatechin-3-gallate:Dexolve complex(FFS-EGCG:Dexolve)for site-specific treatment of throat cancer using newer excipients.Methods:...Background:The present study aimed to develop a film-forming spray containing an epigallocatechin-3-gallate:Dexolve complex(FFS-EGCG:Dexolve)for site-specific treatment of throat cancer using newer excipients.Methods:EGCG was used to treat throat cancer.The permeability of EGCG was improved by amalgamating with Kleptose/Dexolve.The screened complex was loaded into a film-forming spray solution.Quality by design(QbD)was utilized to develop FFS-EGCG:Dexolve,including HPMC E5 and Lycoat.A risk estimation matrix(REM)was utilized to scrutinize critical quality attributes(CQAs)and critical material attributes(CMAs),and a correlation was developed via a Box–Behnken design(BBD).FFS-EGCG:Dexolve was characterized for its in vitro and ex vivo characteristics.Results:EGCG:Dexolve(1:3)had excellent physical properties and 90.83±0.07%permeability.Through an REM,the film formation time and%EGCG released were screened as CQAs,whereas the amounts of HPMC E5,Lycoat,and Dexolve were chosen as CMAs.The amounts of HPMC E5,Lycoat,and Dexolve were considered crucial for designing FFS-EGCG:Dexolve,as determined by the BBD.FFS-EGCG:Dexolve formed instant films,covered a relatively large surface area,and had a long residence time,and controlled EGCG release was achieved for>6 h.The optimal batch comprising HPMC E5(11.98 mg),Lycoat(10.09 mg),and Dexolve(163.5 mg)had excellent spray characteristics,formed a film in 82 s,and released 85.39%EGCG in a controlled manner.Conclusion:A novel FFS-EGCG:Dexolve complex was developed to explore the novel excipients Lycoat,HPMC E5,and Dexolve.The throat-targeted film-forming spray developed a film quickly and released>85%EGCG in 6 h.The novel FFS-EGCG:Dexolve complex was formulated for site specificity and intelligent technologies to achieve better therapeutic efficacy.Patient-centric formulations have excellent industrial and social impacts.展开更多
This paper offers preliminary work on system dynamics and Data mining tools. It tries to understand the dynamics of carrying out large-scale events, such as Hajj. The study looks at a large, recurring problem as a var...This paper offers preliminary work on system dynamics and Data mining tools. It tries to understand the dynamics of carrying out large-scale events, such as Hajj. The study looks at a large, recurring problem as a variable to consider, such as how the flow of people changes over time as well as how location interacts with placement. The predicted data is analyzed using Vensim PLE 32 modeling software, GIS Arc Map 10.2.1, and AnyLogic 7.3.1 software regarding the potential placement of temporal service points, taking into consideration the three dynamic constraints and behavioral aspects: a large population, limitation in time, and space. This research proposes appropriate data analyses to ensure the optimal positioning of the service points with limited time and space for large-scale events. The conceptual framework would be the output of this study. Knowledge may be added to the insights based on the technique.展开更多
文摘Background:The present study aimed to develop a film-forming spray containing an epigallocatechin-3-gallate:Dexolve complex(FFS-EGCG:Dexolve)for site-specific treatment of throat cancer using newer excipients.Methods:EGCG was used to treat throat cancer.The permeability of EGCG was improved by amalgamating with Kleptose/Dexolve.The screened complex was loaded into a film-forming spray solution.Quality by design(QbD)was utilized to develop FFS-EGCG:Dexolve,including HPMC E5 and Lycoat.A risk estimation matrix(REM)was utilized to scrutinize critical quality attributes(CQAs)and critical material attributes(CMAs),and a correlation was developed via a Box–Behnken design(BBD).FFS-EGCG:Dexolve was characterized for its in vitro and ex vivo characteristics.Results:EGCG:Dexolve(1:3)had excellent physical properties and 90.83±0.07%permeability.Through an REM,the film formation time and%EGCG released were screened as CQAs,whereas the amounts of HPMC E5,Lycoat,and Dexolve were chosen as CMAs.The amounts of HPMC E5,Lycoat,and Dexolve were considered crucial for designing FFS-EGCG:Dexolve,as determined by the BBD.FFS-EGCG:Dexolve formed instant films,covered a relatively large surface area,and had a long residence time,and controlled EGCG release was achieved for>6 h.The optimal batch comprising HPMC E5(11.98 mg),Lycoat(10.09 mg),and Dexolve(163.5 mg)had excellent spray characteristics,formed a film in 82 s,and released 85.39%EGCG in a controlled manner.Conclusion:A novel FFS-EGCG:Dexolve complex was developed to explore the novel excipients Lycoat,HPMC E5,and Dexolve.The throat-targeted film-forming spray developed a film quickly and released>85%EGCG in 6 h.The novel FFS-EGCG:Dexolve complex was formulated for site specificity and intelligent technologies to achieve better therapeutic efficacy.Patient-centric formulations have excellent industrial and social impacts.
文摘This paper offers preliminary work on system dynamics and Data mining tools. It tries to understand the dynamics of carrying out large-scale events, such as Hajj. The study looks at a large, recurring problem as a variable to consider, such as how the flow of people changes over time as well as how location interacts with placement. The predicted data is analyzed using Vensim PLE 32 modeling software, GIS Arc Map 10.2.1, and AnyLogic 7.3.1 software regarding the potential placement of temporal service points, taking into consideration the three dynamic constraints and behavioral aspects: a large population, limitation in time, and space. This research proposes appropriate data analyses to ensure the optimal positioning of the service points with limited time and space for large-scale events. The conceptual framework would be the output of this study. Knowledge may be added to the insights based on the technique.
