目的:探讨微创全瓷贴面配合数字化微笑设计(Digital smile design,DSD)技术修复前牙切缘切角缺损的美学效果。方法:选取2019年1月-2022年1月笔者医院接诊的78例前牙切缘切角缺损患者为研究对象,采用区组随机化法分为观察组(116颗患牙)...目的:探讨微创全瓷贴面配合数字化微笑设计(Digital smile design,DSD)技术修复前牙切缘切角缺损的美学效果。方法:选取2019年1月-2022年1月笔者医院接诊的78例前牙切缘切角缺损患者为研究对象,采用区组随机化法分为观察组(116颗患牙)和对照组(120颗患牙),每组39例。对照组采用微创全瓷贴面修复,观察组给予微创全瓷贴面联合DSD技术进行修复。比较两组患者治疗6个月后的满意度、美学效果[美国公共卫生署评估标准(United states public health service,USPHS)],对比治疗前后两组患者的红色美学指数、牙周健康指数[牙龈指数(Gingival index,GI)、牙菌斑指数(Plaque index,PLI)、龈沟出血指数(Sulcus bleeding index,SBI)]的变化。结果:治疗6个月后,两组美学效果各维度评级有显著差异,观察组治疗满意率、红色美学指数评分均显著高于对照组(P<0.05);治疗6个月后,两组GI、PLI、SBI均明显降低,且观察组显著低于对照组(P<0.05)。结论:微创全瓷贴面联合DSD技术修复前牙切缘切角缺损可有效改善牙齿美学效果,提高患者治疗满意度,适合临床推广。展开更多
生猪种业是国家战略性、基础性核心产业,其为养猪业的长期稳定发展提供了重要支撑。具有XX染色体型的性别发育异常(Disorder of Sex Development with XX karyotype,XX-DSD)的间性猪,其生殖系统异常发育,严重制约了种猪的高效生产,影响...生猪种业是国家战略性、基础性核心产业,其为养猪业的长期稳定发展提供了重要支撑。具有XX染色体型的性别发育异常(Disorder of Sex Development with XX karyotype,XX-DSD)的间性猪,其生殖系统异常发育,严重制约了种猪的高效生产,影响了生猪养殖的经济效益。建立间性猪的精准分子诊断技术能确保引种优化和种猪遗传改良,为人类性别发育异常提供动物模型,助力农用猪和医用猪的高质量发展。本文综述了人类及其他模式动物XX-DSD的分类、调控因素和候选基因变异,重点阐述了间性猪的分类、表征、遗传力和分子遗传研究,以期为间性猪的遗传诊断提供重要的理论参考。展开更多
Ovotesticular disorder of sex development (OT-DSD) is a condition in which, both testicular tissue and ovarian tissue are co-existent in the same gonad (ovotestis) or independently in separate gonads characterizing th...Ovotesticular disorder of sex development (OT-DSD) is a condition in which, both testicular tissue and ovarian tissue are co-existent in the same gonad (ovotestis) or independently in separate gonads characterizing the anatomical form of lateral ovotestis. Here, in this study, we report a case of lateral ovotestis associated with a chimera, Chi 46,XX/46,XY. He presented for fertility assessment and karyotyping because of DSD characterized by gynecomastia associated with hypospadias;Karyotyping of peripheral blood revealed a 46,XX/46,XY chimeric condition confirmed by SNP array analysis. After surgical exploration, an hemi-uterus with its tube and gonad was found and remove. Histology revealed ovarian tissue with follicules at different stage while semen analysis revealed a severe oligoastheno teratozoospermia. A gonad was palpable on the right hemiscrotum and ultrasound showed a testis structure. The patient clamed conservation of its testicle and requested bilateral mastectomy. A multidisciplinary approach was warranted to establish this rare entity’s diagnosis and its management. In the case of gonad preservation, the risk of gonadoblastom is to be discussed and follow up recommended.展开更多
文摘目的:探讨微创全瓷贴面配合数字化微笑设计(Digital smile design,DSD)技术修复前牙切缘切角缺损的美学效果。方法:选取2019年1月-2022年1月笔者医院接诊的78例前牙切缘切角缺损患者为研究对象,采用区组随机化法分为观察组(116颗患牙)和对照组(120颗患牙),每组39例。对照组采用微创全瓷贴面修复,观察组给予微创全瓷贴面联合DSD技术进行修复。比较两组患者治疗6个月后的满意度、美学效果[美国公共卫生署评估标准(United states public health service,USPHS)],对比治疗前后两组患者的红色美学指数、牙周健康指数[牙龈指数(Gingival index,GI)、牙菌斑指数(Plaque index,PLI)、龈沟出血指数(Sulcus bleeding index,SBI)]的变化。结果:治疗6个月后,两组美学效果各维度评级有显著差异,观察组治疗满意率、红色美学指数评分均显著高于对照组(P<0.05);治疗6个月后,两组GI、PLI、SBI均明显降低,且观察组显著低于对照组(P<0.05)。结论:微创全瓷贴面联合DSD技术修复前牙切缘切角缺损可有效改善牙齿美学效果,提高患者治疗满意度,适合临床推广。
文摘生猪种业是国家战略性、基础性核心产业,其为养猪业的长期稳定发展提供了重要支撑。具有XX染色体型的性别发育异常(Disorder of Sex Development with XX karyotype,XX-DSD)的间性猪,其生殖系统异常发育,严重制约了种猪的高效生产,影响了生猪养殖的经济效益。建立间性猪的精准分子诊断技术能确保引种优化和种猪遗传改良,为人类性别发育异常提供动物模型,助力农用猪和医用猪的高质量发展。本文综述了人类及其他模式动物XX-DSD的分类、调控因素和候选基因变异,重点阐述了间性猪的分类、表征、遗传力和分子遗传研究,以期为间性猪的遗传诊断提供重要的理论参考。
文摘Ovotesticular disorder of sex development (OT-DSD) is a condition in which, both testicular tissue and ovarian tissue are co-existent in the same gonad (ovotestis) or independently in separate gonads characterizing the anatomical form of lateral ovotestis. Here, in this study, we report a case of lateral ovotestis associated with a chimera, Chi 46,XX/46,XY. He presented for fertility assessment and karyotyping because of DSD characterized by gynecomastia associated with hypospadias;Karyotyping of peripheral blood revealed a 46,XX/46,XY chimeric condition confirmed by SNP array analysis. After surgical exploration, an hemi-uterus with its tube and gonad was found and remove. Histology revealed ovarian tissue with follicules at different stage while semen analysis revealed a severe oligoastheno teratozoospermia. A gonad was palpable on the right hemiscrotum and ultrasound showed a testis structure. The patient clamed conservation of its testicle and requested bilateral mastectomy. A multidisciplinary approach was warranted to establish this rare entity’s diagnosis and its management. In the case of gonad preservation, the risk of gonadoblastom is to be discussed and follow up recommended.
