Considering the pivotal role of single-wavelength anomalous diffraction(SAD) in macromolecular crystallography,our objective was to introduce DSAS,a novel program designed for efficient anomalous scattering substructu...Considering the pivotal role of single-wavelength anomalous diffraction(SAD) in macromolecular crystallography,our objective was to introduce DSAS,a novel program designed for efficient anomalous scattering substructure determination.DSAS stands out with its core components:a modified phase-retrieval algorithm and automated parameter tuning.The software boasts an intuitive graphical user interface(GUI),facilitating seamless input of essential data and real-time monitoring.Extensive testing on DSAS has involved diverse datasets,encompassing proteins,nucleic acids,and various anomalous scatters such as sulfur(S),selenium(Se),metals,and halogens.The results confirm DSAS’s exceptional performance in accurately determining heavy atom positions,making it a highly effective tool in the field.展开更多
This study explains the multi-decadal shoreline changes along the coast of Kanyakumari from 1980 to2020.The shorelines are extracted from the Landsat images to estimate the shoreline dynamics and future predictions us...This study explains the multi-decadal shoreline changes along the coast of Kanyakumari from 1980 to2020.The shorelines are extracted from the Landsat images to estimate the shoreline dynamics and future predictions using Digital Shoreline Analysis System(DSAS).By the estimation of End Point Rate(EPR)and Linear Regression Rate(LRR),it is quantified that the maximum erosion is 5.01 m/yr(EPR)and 6.13 m/yr(LRR)consistently with the maximum accretion of 3.77 m/yr(EPR)and 3.11 m/yr(LRR)along the entire coastal stretch of 77 km.The future shoreline predicted using the Kalman filter forecasted that Inayam,Periyakattuthurai and Kodimunai are highly prone to erosion with a shift of 170 m,157 m and 145 m by 2030 and 194 m,182 m and 165 m by 2040 towards the land.Also,the western coast is highly prone to erosion and it is predicted that certain villages are prone to loss of economy and livelihood.The outcome of this study may guide the coastal researchers to understand the evolution and decisionmakers to evolve with alternative sustainable management plans in the future.展开更多
One of the pathways to attain NET ZERO is CO_(2)injection into deep saline aquifers(DSAs),which alters the saturation and pore pressure of the reservoir rocks,hence the effective stress,sʹ.This,in turn,would change th...One of the pathways to attain NET ZERO is CO_(2)injection into deep saline aquifers(DSAs),which alters the saturation and pore pressure of the reservoir rocks,hence the effective stress,sʹ.This,in turn,would change their geomechanical(i.e.peak deviatoric stress,elastic modulus,Poisson's ratio)and petrophysical(porosity and permeability)properties.Such a situation might trigger geo-hazards,like induced seismicity,ground deformation,caprock failure.Hence,reducing the risk of such hazards necessitates quantifying the spatial and temporal changes in sʹ,under specific CO_(2)and/or brine saturation,designated as S_(CO2)and S_(b),respectively,and resultant pore pressure.With this in view,a conceptual model depicting the reservoir,demarcated by five zones based on variations in saturation,pore-pressure,temperature,etc.,and the corresponding effective stress equations have been proposed based on the available literature.Furthermore,a critical review of literature has been carried out to decipher the limitations and contradictions associated with the findings from(i)laboratory studies to estimate S_(CO2)employing pwave velocity and electrical resistivity,(ii)analytical and numerical approaches for estimating the variation of pore-pressure in the reservoir rocks,and(iii)laboratory studies on variation in geomechanical and petrophysical properties under the conditions representative of the above-mentioned zones of the conceptual model.The authors consider that extensive experiments should be conducted on the rocks from different sources and tested under various conditions of the CO_(2)injection to validate the proposed model for the execution of risk-free CO_(2)storage in DSAs.展开更多
目的:探讨颅内静脉窦血栓形成合并脑出血的临床特点及诊疗过程。方法:选取2024年10月青岛大学附属医院收治的颅内静脉窦血栓形成患者1例,回顾分析临床、实验室资料,并复习既往相关文献。结果:32岁女性患者因“头痛3天,意识障碍1天”入院...目的:探讨颅内静脉窦血栓形成合并脑出血的临床特点及诊疗过程。方法:选取2024年10月青岛大学附属医院收治的颅内静脉窦血栓形成患者1例,回顾分析临床、实验室资料,并复习既往相关文献。结果:32岁女性患者因“头痛3天,意识障碍1天”入院,急诊行数字血管造影(DSA)取栓治疗,患者合并脑出血,后续颅内压增高,行颅内血肿清除术 + 去骨瓣减压术。患者病情好转后3个月行颅骨修补术 + 腰大池引流术,复查相关影像学检测示颅内静脉窦血栓消失。结论:服用性激素类药物育龄期妇女,出现头痛、意识障碍、癫痫等临床表现,需要警惕颅内静脉窦血栓形成可能。在治疗过程中,患者可能有梗死后出血情况发生,需密切关注症状体征的变化,及时针对引起病情变化的病因予以治疗。Objective: To investigate the clinical features, diagnosis, and treatment of cerebral venous sinus thrombosis (CVST) complicated with cerebral hemorrhage. Methods: A patient with cerebral venous sinus thrombosis admitted to the Affiliated Hospital of Qingdao University in October 2024 was selected. The clinical and laboratory data were retrospectively analyzed, and the previous relevant literature was reviewed. Results: A 32-year-old female patient was admitted to the hospital due to a headache for 3 days and disturbance of consciousness for 1 day. Emergency digital subtraction angiography (DSA) thrombectomy was performed for the patient with cerebral hemorrhage, and the subsequent increased intracranial pressure was treated with intracranial hematoma evacuation and decompressive craniectomy. Cranioplasty and lumbar drainage were performed 3 months after the patient’s condition improved, and the relevant imaging examination showed that the cerebral venous sinus thrombosis had disappeared. Conclusion: Women of childbearing age who take sex hormone drugs and have clinical manifestations such as headache, disturbance of consciousness, and epilepsy should be alert to the possibility of cerebral venous sinus thrombosis. During the treatment, patients may have post-infarction hemorrhage, so it is necessary to pay close attention to the changes in symptoms and signs and treat the causes of the changes in the condition in time.展开更多
基金Project supported by the National Natural Science Foundation of China(Grant Nos.32371280 and T2350011)。
文摘Considering the pivotal role of single-wavelength anomalous diffraction(SAD) in macromolecular crystallography,our objective was to introduce DSAS,a novel program designed for efficient anomalous scattering substructure determination.DSAS stands out with its core components:a modified phase-retrieval algorithm and automated parameter tuning.The software boasts an intuitive graphical user interface(GUI),facilitating seamless input of essential data and real-time monitoring.Extensive testing on DSAS has involved diverse datasets,encompassing proteins,nucleic acids,and various anomalous scatters such as sulfur(S),selenium(Se),metals,and halogens.The results confirm DSAS’s exceptional performance in accurately determining heavy atom positions,making it a highly effective tool in the field.
文摘This study explains the multi-decadal shoreline changes along the coast of Kanyakumari from 1980 to2020.The shorelines are extracted from the Landsat images to estimate the shoreline dynamics and future predictions using Digital Shoreline Analysis System(DSAS).By the estimation of End Point Rate(EPR)and Linear Regression Rate(LRR),it is quantified that the maximum erosion is 5.01 m/yr(EPR)and 6.13 m/yr(LRR)consistently with the maximum accretion of 3.77 m/yr(EPR)and 3.11 m/yr(LRR)along the entire coastal stretch of 77 km.The future shoreline predicted using the Kalman filter forecasted that Inayam,Periyakattuthurai and Kodimunai are highly prone to erosion with a shift of 170 m,157 m and 145 m by 2030 and 194 m,182 m and 165 m by 2040 towards the land.Also,the western coast is highly prone to erosion and it is predicted that certain villages are prone to loss of economy and livelihood.The outcome of this study may guide the coastal researchers to understand the evolution and decisionmakers to evolve with alternative sustainable management plans in the future.
基金The authors would like to acknowledge the grant of fellowship(DST/TMD/EWO/2K21/ACT/2021/02(G))under Project SHARP,received from the Department of Science and Technology,Government of India.
文摘One of the pathways to attain NET ZERO is CO_(2)injection into deep saline aquifers(DSAs),which alters the saturation and pore pressure of the reservoir rocks,hence the effective stress,sʹ.This,in turn,would change their geomechanical(i.e.peak deviatoric stress,elastic modulus,Poisson's ratio)and petrophysical(porosity and permeability)properties.Such a situation might trigger geo-hazards,like induced seismicity,ground deformation,caprock failure.Hence,reducing the risk of such hazards necessitates quantifying the spatial and temporal changes in sʹ,under specific CO_(2)and/or brine saturation,designated as S_(CO2)and S_(b),respectively,and resultant pore pressure.With this in view,a conceptual model depicting the reservoir,demarcated by five zones based on variations in saturation,pore-pressure,temperature,etc.,and the corresponding effective stress equations have been proposed based on the available literature.Furthermore,a critical review of literature has been carried out to decipher the limitations and contradictions associated with the findings from(i)laboratory studies to estimate S_(CO2)employing pwave velocity and electrical resistivity,(ii)analytical and numerical approaches for estimating the variation of pore-pressure in the reservoir rocks,and(iii)laboratory studies on variation in geomechanical and petrophysical properties under the conditions representative of the above-mentioned zones of the conceptual model.The authors consider that extensive experiments should be conducted on the rocks from different sources and tested under various conditions of the CO_(2)injection to validate the proposed model for the execution of risk-free CO_(2)storage in DSAs.
文摘目的:探讨颅内静脉窦血栓形成合并脑出血的临床特点及诊疗过程。方法:选取2024年10月青岛大学附属医院收治的颅内静脉窦血栓形成患者1例,回顾分析临床、实验室资料,并复习既往相关文献。结果:32岁女性患者因“头痛3天,意识障碍1天”入院,急诊行数字血管造影(DSA)取栓治疗,患者合并脑出血,后续颅内压增高,行颅内血肿清除术 + 去骨瓣减压术。患者病情好转后3个月行颅骨修补术 + 腰大池引流术,复查相关影像学检测示颅内静脉窦血栓消失。结论:服用性激素类药物育龄期妇女,出现头痛、意识障碍、癫痫等临床表现,需要警惕颅内静脉窦血栓形成可能。在治疗过程中,患者可能有梗死后出血情况发生,需密切关注症状体征的变化,及时针对引起病情变化的病因予以治疗。Objective: To investigate the clinical features, diagnosis, and treatment of cerebral venous sinus thrombosis (CVST) complicated with cerebral hemorrhage. Methods: A patient with cerebral venous sinus thrombosis admitted to the Affiliated Hospital of Qingdao University in October 2024 was selected. The clinical and laboratory data were retrospectively analyzed, and the previous relevant literature was reviewed. Results: A 32-year-old female patient was admitted to the hospital due to a headache for 3 days and disturbance of consciousness for 1 day. Emergency digital subtraction angiography (DSA) thrombectomy was performed for the patient with cerebral hemorrhage, and the subsequent increased intracranial pressure was treated with intracranial hematoma evacuation and decompressive craniectomy. Cranioplasty and lumbar drainage were performed 3 months after the patient’s condition improved, and the relevant imaging examination showed that the cerebral venous sinus thrombosis had disappeared. Conclusion: Women of childbearing age who take sex hormone drugs and have clinical manifestations such as headache, disturbance of consciousness, and epilepsy should be alert to the possibility of cerebral venous sinus thrombosis. During the treatment, patients may have post-infarction hemorrhage, so it is necessary to pay close attention to the changes in symptoms and signs and treat the causes of the changes in the condition in time.
