Drought is an important disaster factor disturbing the stability of the ecosystem in the middle reaches of the Yellow River(YRM).In this study,the spatiotemporal distribution of drought in the YRM from 2000 to 2021 wa...Drought is an important disaster factor disturbing the stability of the ecosystem in the middle reaches of the Yellow River(YRM).In this study,the spatiotemporal distribution of drought in the YRM from 2000 to 2021 was quantitatively investigated by constructing the TVPDI(Temperature-VegetationPrecipitation Dryness Index),and its driving mechanism was explored.The results show that:(1)a significant decreasing trend was observed in the regional annual TVPDI of the YRM,while the autumn TVPDI index showed an increasing trend during 2000-2021.(2)Plants are more susceptible to drought during the growing season.(3)Drought in YRM showed significant spatial heterogeneity,and the high gully area in the Loess Plateau and the earth-rocky mountain areas were less affected by drought than other regions.(4)The Structural Equation Model(SEM)indicated that regional soil moisture and vegetation coverage have a direct influence on regional TVPDI variation.This study has explored the regional differences of drought in different seasons and landforms in the YRM,providing a basis for carrying out targeted seasonal ecological management and refining regional environmental governance,as well as a reference for formulating differentiated ecological restoration and water resource allocation strategies according to local conditions.展开更多
OBJECTIVE:To investigate the role of toll-like receptor 4(TLR4)/mutant myeloid differentiation primary response 88(MyD88)/nuclear factor kappa-B(NF-κB)signaling pathway-mediated inflammation in diabetes mellitus with...OBJECTIVE:To investigate the role of toll-like receptor 4(TLR4)/mutant myeloid differentiation primary response 88(MyD88)/nuclear factor kappa-B(NF-κB)signaling pathway-mediated inflammation in diabetes mellitus with Northwest dryness syndrome.METHODS:Rats were randomly divided into the normal control,type 2 diabetes(T2DM)model,Northwest dryness syndrome+T2DM(Northwest dryness),and simple internal dampness+T2DM(internal dampness)groups.Enzyme-linked immunosorbent assay was used to detect biochemical indexes and inflammatory factors.The histopathological observation was performed.Quantitative real-time polymerase chain reaction and Western blot analysis were used to detect the mRNA and protein expression levels,respectively.RESULTS:Compared with the T2DM group,the glycosylated hemoglobin A1c,insulin,glucose tolerance,the homeostasis model assessment of insulin resistance,tumor necrosis factor-α,interleukin 1β,interleukin 16,malondialdehyde,blood lipid,alanine aminotransferase,and aspartate aminotransferase were significantly elevated in the internal dampness group.Their levels were significantly elevated in the Northwest dryness group than in the T2DM and internal dampness groups.The superoxide dismutase,glutathione peroxidase,liver glycogen,and organ-to-weight ratio were significantly declined in the internal dampness group and the Northwest dryness group than in the T2DM group.However,these levels were elevated in the Northwest dryness group than in the internal dampness group.Moreover,the mRNA expression levels of interferon regulatory factor 5 and NF-κB p65,and the protein expression levels of TLR4,MyD88,and NF-κB were significantly higher in the internal dampness and the Northwest dryness groups than the T2DM group.Additionally,the mRNA and protein levels were significantly higher in the Northwest dryness group than in the internal dampness group.CONCLUSION:Northwest dryness syndrome-mediated TLR4/MyD88/NF-κB pathway and chronic inflammation might be associated with the occurrence and development of T2DM.展开更多
Spatio-temporal dynamic monitoring of soil moisture is highly important to management of agricultural and vegetation eco-systems.The temperature-vegetation dryness index based on the triangle or trapezoid method has b...Spatio-temporal dynamic monitoring of soil moisture is highly important to management of agricultural and vegetation eco-systems.The temperature-vegetation dryness index based on the triangle or trapezoid method has been used widely in previous studies.However,most existing studies simply used linear regression to construct empirical models to fit the edges of the feature space.This requires extensive data from a vast study area,and may lead to subjective results.In this study,a Modified Temperature-Vegetation Dryness Index(MTVDI)was used to monitor surface soil moisture status using MODIS(Moderate-resolution Imaging Spectroradiometer)remote sensing data,in which the dry edge conditions were determined at the pixel scale based on surface energy balance.The MTVDI was validated by field measurements at 30 sites for 10 d and compared with the Temperature-Vegetation Dryness Index(TVDI).The results showed that the R^(2) for MTVDI and soil moisture obviously improved(0.45 for TVDI,0.69 for MTVDI).As for spatial changes,MTVDI can also better reflect the actual soil moisture condition than TVDI.As a result,MTVDI can be considered an effective method to monitor the spatio-temporal changes in surface soil moisture on a regional scale.展开更多
Moderate resolution imaging spectroradiometer （MODIS） data are very suitable for vast extent, long term and dynamic drought monitoring for its high temporal resolution, high spectral resolution and moderate spatial ...Moderate resolution imaging spectroradiometer （MODIS） data are very suitable for vast extent, long term and dynamic drought monitoring for its high temporal resolution, high spectral resolution and moderate spatial resolution. The composite Enhanced Vegetation Index （EVI） and composite land surface temperature （Ts） obtained from MODIS data MOD11A2 and MOD13A2 were used to construct the EVI-Ts space. And Temperature Vegetation Dryness Index （TVDI） was calculated to evaluate the agriculture drought in Guangxi province, China in October of 2006. The results showed that the drought area in Guangxi was evidently increasing and continuously deteriorating from the middle of September to the middle of November. The TVDI, coming from the EVI-Ts space, could effectively indicate the spatial distribution and temporal evolution of drought, so that it could provide a strong technical support for the forecasting agricultural drought in south China.展开更多
Linear regression,climate trend rate,integral humidity indicator and dry-wet index were adopted to analyze the precipitation change,drought or waterlogging frequency and occurrence period in Benxi of Liaoning.The resu...Linear regression,climate trend rate,integral humidity indicator and dry-wet index were adopted to analyze the precipitation change,drought or waterlogging frequency and occurrence period in Benxi of Liaoning.The results showed that in recent 55 years,the tendency rate of annual precipitation in Benxi was-30.749 mm/10 a,reducing 165 mm in trend;the precipitation tendency rate during the growing season of plants was-31.371/10 a,reducing 173 mm in trend.The climate type was changed from light flood 20 a ago to wet type.The satisfaction of agriculture-required water was above 150% and annual average precipitation surplus was 290 mm.Benxi was hit by the medium floods to heavy floods in 10 years,about once in five years.The occurrence period of mild drought was 5 a,about once in ten years.The drought in spring below the medium degree occurred twice in a decade while the waterlogging above the medium degree occurred once in a decade.The waterlogging in summer above the medium degree occurred once in two years.The waterlogging in autumn above the medium degree occurred twice in a decade while the drought below the medium degree occurred four times in a decade.The occurrence frequency of heavy waterlogging in July and August was 54.5%.May and September were the period of time with a strikingly higher prevalence in drought.展开更多
The Chikugo Model is used to estimate radiative dryness indexes (RDI) and net primary productivity (NPP) of vegetation zones in China by calculating cli-matic parameters. That provides the water-heat equilibrium condi...The Chikugo Model is used to estimate radiative dryness indexes (RDI) and net primary productivity (NPP) of vegetation zones in China by calculating cli-matic parameters. That provides the water-heat equilibrium condition, potential primary production for natural vegetation in various vegetation zones, and their geographical distribution pattern. That could be used as the basis for study the effect of global climate change on ecosystems.展开更多
Using Moderate Resolution Imaging Spectroradiometer(MODIS) data from the dry season during 2010–2012 over the whole Yunnan Province, an improved temperature vegetation dryness index(iTVDI), in which a parabolic dry-e...Using Moderate Resolution Imaging Spectroradiometer(MODIS) data from the dry season during 2010–2012 over the whole Yunnan Province, an improved temperature vegetation dryness index(iTVDI), in which a parabolic dry-edge equation replaces the traditional linear dry-edge equation, was developed, to reveal the regional drought regime in the dry season. After calculating the correlation coefficient, root-mean-square error, and standard deviation between the iTVDI and observed topsoil moisture at 10 and 20 cm for seven sites, the effectiveness of the new index in depicting topsoil moisture conditions was verified. The drought area indicated by iTVDI mapping was then compared with the drought-affected area reported by the local government. The results indicated that the iTVDI can monitor drought more accurately than the traditional TVDI during the dry season in Yunnan Province. Using iTVDI facilitates drought warning and irrigation scheduling, and the expectation is that this new index can be broadly applied in other areas.展开更多
Objective:To study on Prof. GAO Zhong-ying’s drug selection law for treatment of chronic gastritis with data mining technique. Methods: The 407 medical records of chronic gastritis treated by Prof. GAO Zhong-ying wer...Objective:To study on Prof. GAO Zhong-ying’s drug selection law for treatment of chronic gastritis with data mining technique. Methods: The 407 medical records of chronic gastritis treated by Prof. GAO Zhong-ying were collected and the study on these drugs in the recipes was carried out with data mining method. Among them, the recipe composed of one drug was studied with frequency statistical method, correlativity between drug pairs with improved mutual information, correlativity among multi-drugs with complex system entropy cluster technique. Results: In treatment of chronic gastritis by Prof. GAO Zhong-ying there were 30 drugs with a higher use frequency of over 38 times, 94 commonly-used drug pairs with correlation coefficient of over 0.05, 11 commonly-used drug core combinations. Conclusion: The results attained with data mining technique for studying experience of famous and old TCM physicians conform to the clinical practice and the method is of an important significance for summarization of famous and old TCM physicians’ experiences.展开更多
OBJECTIVE: To reveal the effects on expression of airway mucus-associated proteins in rats with chronic obstructive pulmonary disease(COPD) and a cold-dryness symptom pattern induced by elastase and smoking.METHODS: T...OBJECTIVE: To reveal the effects on expression of airway mucus-associated proteins in rats with chronic obstructive pulmonary disease(COPD) and a cold-dryness symptom pattern induced by elastase and smoking.METHODS: The COPD model was established with an elastase dose into the trachea combined with exposure to smoking; the COPD model cold-dryness symptom pattern was further developed by exposure to a cold, dry environment. After 90 days,pathologic lung sections, inflammatory cytokine levels(measured by enzyme linked immunosorbent assay), m RNA and protein expression of mucus-associated proteins and aquaporins(measured by real-time polymerase chain reaction and western blots) were examined.RESULTS: Cytokines interleukin-6(IL-6), interleukin-8(IL-8), and tumor necrosis factor-α(TNF-α) in the COPD and the cold-dryness symptom pattern COPD groups were all significantly higher than in controls(each P < 0.01). IL-6 and IL-8 levels were higher in the cold-dryness symptom pattern COPD group than in the COPD group(each P < 0.05). The AQP5 m RNA expression in the cold-dryness symptom pattern COPD and COPD groups was lower than in the control group(P < 0.01), and that in the cold-dryness symptom pattern COPD group was lower than the COPD group(P < 0.05). The expression of MUC5 AC and MUC5 B m RNAs in the cold-dryness symptom pattern COPD group and COPD group was higher than in the control group(each P < 0.01), and that in the cold-dryness symptom pattern COPD group was higher than the COPD group(P < 0.01, and P < 0.05, respectively).The ratio of MUC5 AC m RNA/MUC5 B m RNA was COPD group < the cold-dryness symptom pattern COPD group < the control group. AQP4 and AQP5 protein expression in the cold-dryness symptom pattern COPD group was lower than that in the COPD group which was lower again than in the control group. MUC5 AC and MUC5 B expression in the cold-dryness symptom pattern COPD group was higher than in the COPD group and higher again than in the control group.CONCLUSION: Cold-dryness affects the expression of mucus-associated protein m RNA and its corresponding proteins, reducing the secretion of aquaporins and increasing the secretion of mucins. Imbalance in aquaporins and mucins can affect the function of mucus, increasing airway obstruction.展开更多
OBJECTIVE:To investigate the relationship between gene polymorphism of peroxisome proliferator-activated receptor(PPAR) and susceptibility to northwest dryness syndrome(NDS).METHODS:The polymorphisms of 11 PPARl51, r...OBJECTIVE:To investigate the relationship between gene polymorphism of peroxisome proliferator-activated receptor(PPAR) and susceptibility to northwest dryness syndrome(NDS).METHODS:The polymorphisms of 11 PPARl51, rs13γ7 gene oci rs10510418, rs1263353640,rs17036188, rs2921190, rs4135247, rs4135275,rs4135283, rs6768587, rs709156, and rs7615916 were detected in 249 patients with NDS and 260 patients with non-NDS(control group) by using Snapshot single-nucleotide polymorphism typing technology.RESULTS:All locus detections were in accordance with Hardy-Weinberg equilibrium test.Compared with the control group, rs2921190 genotype frequency showed statistical difference in the NDS group(P < 0.05).Two-two comparison result showed that CC genotype frequency in the NDS group was higher than that in the control group.CT and TT genotype distribution frequencies showed differences between the two groups.The rare allele frequency in the NDS group was lower than that of the control group(P < 0.01).Multi-factor logistic regression analysis showed that the age and genotype entered the regression equation.The subjects in the age bracket 30-55 and 45-45 were1.796 and 1.561 times likely, respectively, than those in other age brackets to contract NDS,.The patients with CC genotype was only 0.524 times likely than those with CT/TT genotype to suffer from NDS.CONCLUSION:PPARsm was correlated γw gene rs2921190 polymorphiith the susceptibility to NDS.展开更多
Using indexes of dryness and wetness in historical record over the recent recent years and rainfall data over the tatest century, the work involves itself with the study of climatological evolution of dryness and wetn...Using indexes of dryness and wetness in historical record over the recent recent years and rainfall data over the tatest century, the work involves itself with the study of climatological evolution of dryness and wetness. periodic variations of climate and interannual laws of variation. The discussion also covers the subjects of effects of El Nino. sunspot, predictors of general circulation on climatic variation of dryness and wetness. There arc main conclusions as follows: (1) The main cyclic variations of climate are 40 and 11 years in Kunming. the former being subject to that of El Nino and the latter to that of sunspots. They are two principal factors for periodic variations of dryness and wetness in Kunming. (2) A close relationship exists between interannual variations and general circulation factors for Kunming. The comprehensive influence as imposed by ENSO and allocations of W.C.E. patterns of circulation in the westerly are ma.tor weather and climate causes for the interannual variations of precipitation in Kunming.展开更多
Precipitation data from 86 observing Stations for the past four decades (from the first operational use to 1994) are used to study and discuss the character of annually mean distribution in Guangdong. Grades of drynes...Precipitation data from 86 observing Stations for the past four decades (from the first operational use to 1994) are used to study and discuss the character of annually mean distribution in Guangdong. Grades of dryness and wetness on a year-to-year basis are determined and preliminary features of dryness and wetness are discussed for the whole of the province and individual regions according to a 5-grade standard of division. The result has shown that there is on an average a rainfall of 1748 mm per year across the province, with four major centers of maxima (of annual rainfall over 2000 mm) at Enping, Qingyuan, Haifeng and Longmen. For the mean across the province, the years 1959. 1 961. 1973.1975, 1991 are anomalously wet and the years 1956, 1963, 1977 and 1991 are anomalously dry. of them, 1973 is the unusually wet year (with the absolute value of precipitation anomaly over twice as large as the standard deviation) and 1956 and 1963 are the usual dry years. For the occurrence frequency of unusually wetness and dryness over individual river valleys in the province, there are more years of dryness in the valleys of the Xijiang and Dongjiang Rivers. More years of wetness in that of the Jianjiang River, and only years of wetness instead of years of dryness in the valleys of Beijiang and Hanjiang Rivers.展开更多
Dryness and wetness variations on different time scales in Shanghai were analyzed using the Standardized Precipitation Index （SPI） based on monthly precipitation data for 1873-2005. The SPI on scales of 3, 6, 12 and...Dryness and wetness variations on different time scales in Shanghai were analyzed using the Standardized Precipitation Index （SPI） based on monthly precipitation data for 1873-2005. The SPI on scales of 3, 6, 12 and 24 months has been calculated. The SPI on 3, 6, 12 and 24 months present 4 wet periods prevailed during 1873-1885, 1904-1923, 1938-1960 and 1983-2005, and 3 dry episodes during 1886-1903, 1924-1937 and 1961-1982. Significant periods of higher wavelet power in the SPI-24 months occurred on the time scales of 2-7-year band in around 1880-1890, 1910-1950 and 1970-1990, and at 8-15-year band in 1920-1960 and 1965-2000 respectively. Periodicities in the SOl and ENSO indices are similar to those in SPI-24 months with little difference, namely, in the SPI-24 months, there are significant periods at the 2-7- and 8-15-year bands during 1930-1940. The periodicity components in individual SPI-24 months, SOl and ENSO indices are more complicated, showing the wetness and dryness variability in Shanghai is controlled by more than one physical factors. The research results indicate that the Shanghai area has experienced dryness and wetness variability on different time scales during the past 133 years.展开更多
The Enhanced Geothermal System(EGS) is a recognized geothermal exploitation system for hot dry rock(HDR), which is a rich resource in China. In this study, a numerical simulation method is used to study the effects of...The Enhanced Geothermal System(EGS) is a recognized geothermal exploitation system for hot dry rock(HDR), which is a rich resource in China. In this study, a numerical simulation method is used to study the effects of geothermal fluid dryness and non-condensable gas content on the specific enthalpy of geothermal fluid. Combined with the organic Rankine cycle(ORC), a numerical model is established to ascertain the difference in power generation caused by geothermal fluid dryness and non-condensable gas content. The results show that the specific enthalpy of geothermal fluid increases with the increase of geothermal fluid temperature and geothermal fluid dryness. If the dryness of geothermal fluid is ignored, the estimation error will be large for geothermal fluid enthalpy. Ignoring non condensable gas will increase the estimation of geothermal fluid enthalpy, so the existence of the non-condensable gas tends to reduce the installed capacity of a geothermal power plant. Additionally, both mass flow of the working medium and net power output of the ORC power generation system are increased with increasing dryness of geothermal fluid, however there is some impact of geothermal fluid dryness on thermal efficiency.展开更多
The aim of this study was to compare serum 17β-estradiol of menopausal women with/without Oral Dryness (OD) feeling, and evaluate the re-lationship between serum 17β-estradiol and severity of OD feeling. A case-cont...The aim of this study was to compare serum 17β-estradiol of menopausal women with/without Oral Dryness (OD) feeling, and evaluate the re-lationship between serum 17β-estradiol and severity of OD feeling. A case-control study was carried out on 70 selected menopausal women aged 40 - 77 years with or without OD feeling (35 as case, 35 as control) conducted at the Clinic of Oral Medicine, Tehran University of Medical Sciences. Xerostomia inventory (XI) score was used as an index of OD feeling severity. The serum 17β-estradiol concentration was measured by an enzyme immunoassay kit (ELISA). Statistical analysis of Student’s t-test and Spearman correlation coefficient was used. The mean serum concentration of 17β-estradiol was significantly lower in case than control. There was a significant negative correlation between XI score and concentration of 17β-estradiol in menopausal women (r = –0.311, P = 0.004). It seems that there is a negatively slight correlation between OD feeling severity and serum 17β-estradiol in menopausal women.展开更多
As a syndrome with tapping incision blocked partly or entirely during latex exploiting in rubber tree （Hevea brasiliensis ）, ＂Tapping panel dryness （TPD）＂ causes great yield losses, thereby becoming the most imp...As a syndrome with tapping incision blocked partly or entirely during latex exploiting in rubber tree （Hevea brasiliensis ）, ＂Tapping panel dryness （TPD）＂ causes great yield losses, thereby becoming the most important factor limiting rubber production. On the basis of an EST down-regulated in TPD-affected rubber trees, a 903 bp cDNA denoted HbPIP2;2 was isolated from the bark tissue with a combination of in silico cloning and RT-PCR. The cDNA contains an 867 hp ORF, 13 bp 5＇UTR and 23 bp 3＇ UTR. Sequence analysis indicated that HbPIP2;2 encodes 288 amino acids with a theoretical molecular weight （Mw） of 30. 71 kDa and isolectric point （Pi） of 8.20. Bioinformatics analysis suggested that the deduced protein is predicted to have six transmembrane helices located to the plasma membrane and harbor one conserved MIP domain that can be grouped into plasma membrane intrinsic proteins （PIPs） of aquaporin （AQP） family. Homolo- gy search revealed that the protein shares a similarity of more than 90% with the homologues in Ricinus communis, Popttlus trichocarpa, Juglans regia and Theobro- ma cacao, suooorting a hie.hly conserved evolution. This study provided basis for further uncovering the regulatory role of AOPs in TPD occurrence.展开更多
[Objective]To address the role of aquaporins（AQPs）in the occurrence of Tapping Panel Dryness（TPD）,a phenomenon with tapping incision blocked partly or entirely during latex exploiting in the rubber tree（Hevea bra...[Objective]To address the role of aquaporins（AQPs）in the occurrence of Tapping Panel Dryness（TPD）,a phenomenon with tapping incision blocked partly or entirely during latex exploiting in the rubber tree（Hevea brasiliensis）that causes great losses on rubber production,a tonoplast aquaporin gene associated with TPD occurence was cloned and analyzed.[Method]Based on an EST down-regulated in TPD-affected rubber trees,a 774 bp cDNA designated HbTIP1 was isolated from the bark tissue of Hevea brasiliensis with a combination of in silico cloning and RT-PCR.And the gene structure and sequence characteristics were analyzed using bioinformatics tools.[Result]The cDNA includes a 759 bp ORF,8 bp 5’UTR and 7 bp 3’UTR.Sequence analysis indicated that HbTIP1putatively encodes 252 amino acids with a theoretical molecular weight（Mw）of 25.88 kDa and isolectric point（pI）of 4.96.Bioinformatics analysis suggested that the deduced protein is predicted to have six transmembrane helices located to the vacuolar membrane and to harbor one conserved MIP domain that can be grouped into the tonoplast intrinsic proteins（TIPs）of aquaporin family.Homology search revealed that the protein shares a similarity of more than 90%with the homologues in Theobroma cacao,Prunus persica,Citrus sinensis and Ricinus communis,supporting a highly conserved evolution.[Conclusion]This study provided basis for further revealing the regulatory role of AQPs in the TPD occurrence.展开更多
The temperature-vegetation index space coupled with information of surface temperature and vegetation, is an important method to realize soil moisture estimation and agricultural drought monitoring. In order to estima...The temperature-vegetation index space coupled with information of surface temperature and vegetation, is an important method to realize soil moisture estimation and agricultural drought monitoring. In order to estimate the soil moisture in the study area, we collected soil relative humidity of Agricultural meteorological station and downloaded Moderate Resolution Imaging Spectrometer (MODIS) image data. Then, the temperature vegetation dryness index was calculated based on the MODIS Normalized difference vegetation index (NDVI) and land surface temperature (LST). A correlation analysis of TVDI and soil relative humidity at depth of 10 cm was carried out and an empirical model of moisture estimation was established. Finally, another set of data was used to validate the accuracy of model. The results show that the TVDI method can be used to achieve the soil moisture in the study area. The empirical model has certain universality in the study area, and obtains a high accuracy of soil moisture estimation with an R2 of 0.374 and RMSE of 11.73%.展开更多
Temperature sensitivity of soil respiration (Q10) is a critical parameter in carbon cycle models with important implications for climate-carbon feedbacks in the 21st century. The common assumption of a constant Q10, u...Temperature sensitivity of soil respiration (Q10) is a critical parameter in carbon cycle models with important implications for climate-carbon feedbacks in the 21st century. The common assumption of a constant Q10, usually with a value of 2.0, was shown to be invalid by a previous model-data fusion study that reported biome-specific values of this parameter. We extend the previous analysis by demonstrating that these biome-level values of Q10 also are a function of dryness (R2 = 0.54). When tundra and cultivated lands are excluded, the correlation is much stronger (R2 = 0.92). Therefore dryness is the primary driver for variability in respiration-temperature sensitivity in forest and grassland ecosystems. This finding has important implications for the response of the terrestrial carbon cycle to climate change, as it implies that the increasing dryness would potentially accelerate the respiration temperature sensitivity feedback.展开更多
In the study, we report the comparative efficacy of the sodium hyaluronate gel vaginal application and promestriene cream which were tested to treat the gynecological symptoms of people who suffered from vaginal dryne...In the study, we report the comparative efficacy of the sodium hyaluronate gel vaginal application and promestriene cream which were tested to treat the gynecological symptoms of people who suffered from vaginal dryness. Method: 35 patients applied sodium hyaluronate vaginal gel one time a day for a period of two times a week during three weeks and other 33 patients using promestriene cream applied it every day for a period of three weeks also. Results: No significant difference was observed between vaginal application of sodium hyaluronate gel and promestriene cream, regarding both, as regarding the dryness of the intimate mucosa (p = 0.786), the attribute of moisturizing properties to the intimate mucosa (p = 0.142), the comfort sensation (p = 0.528), and no significant difference was observed regarding the fragrance of the product (p = 0.088). Conclusion: The similar results between vaginal application of both products support the use of sodium hyaluronate vaginal gel (Lubrinat®) in the initial approach of symptoms of vaginal dryness.展开更多
基金supported by the National Natural Science Foundation of China(Grant No.41601317)"14th Five Year Plan"For Education Sciences Planning of Shanxi Province(Grant No.SZH-230067)Ideological and Political Courses at Shanxi Normal University(2023KCSZ-15)。
文摘Drought is an important disaster factor disturbing the stability of the ecosystem in the middle reaches of the Yellow River(YRM).In this study,the spatiotemporal distribution of drought in the YRM from 2000 to 2021 was quantitatively investigated by constructing the TVPDI(Temperature-VegetationPrecipitation Dryness Index),and its driving mechanism was explored.The results show that:(1)a significant decreasing trend was observed in the regional annual TVPDI of the YRM,while the autumn TVPDI index showed an increasing trend during 2000-2021.(2)Plants are more susceptible to drought during the growing season.(3)Drought in YRM showed significant spatial heterogeneity,and the high gully area in the Loess Plateau and the earth-rocky mountain areas were less affected by drought than other regions.(4)The Structural Equation Model(SEM)indicated that regional soil moisture and vegetation coverage have a direct influence on regional TVPDI variation.This study has explored the regional differences of drought in different seasons and landforms in the YRM,providing a basis for carrying out targeted seasonal ecological management and refining regional environmental governance,as well as a reference for formulating differentiated ecological restoration and water resource allocation strategies according to local conditions.
基金the State Key Laboratory of Pathogenesis,Prevention and Treatment of High Incidence Diseases in Central Asia-funded Project:Correlation Study on Chronic Inflammation Mediated by Tolllike Receptor 4/Mutant Myeloid Differentiation Primary Response 88/Nuclear Factor Kappa-B Signaling Pathway(No.SKL-HIDCA-2021-ZY5)。
文摘OBJECTIVE:To investigate the role of toll-like receptor 4(TLR4)/mutant myeloid differentiation primary response 88(MyD88)/nuclear factor kappa-B(NF-κB)signaling pathway-mediated inflammation in diabetes mellitus with Northwest dryness syndrome.METHODS:Rats were randomly divided into the normal control,type 2 diabetes(T2DM)model,Northwest dryness syndrome+T2DM(Northwest dryness),and simple internal dampness+T2DM(internal dampness)groups.Enzyme-linked immunosorbent assay was used to detect biochemical indexes and inflammatory factors.The histopathological observation was performed.Quantitative real-time polymerase chain reaction and Western blot analysis were used to detect the mRNA and protein expression levels,respectively.RESULTS:Compared with the T2DM group,the glycosylated hemoglobin A1c,insulin,glucose tolerance,the homeostasis model assessment of insulin resistance,tumor necrosis factor-α,interleukin 1β,interleukin 16,malondialdehyde,blood lipid,alanine aminotransferase,and aspartate aminotransferase were significantly elevated in the internal dampness group.Their levels were significantly elevated in the Northwest dryness group than in the T2DM and internal dampness groups.The superoxide dismutase,glutathione peroxidase,liver glycogen,and organ-to-weight ratio were significantly declined in the internal dampness group and the Northwest dryness group than in the T2DM group.However,these levels were elevated in the Northwest dryness group than in the internal dampness group.Moreover,the mRNA expression levels of interferon regulatory factor 5 and NF-κB p65,and the protein expression levels of TLR4,MyD88,and NF-κB were significantly higher in the internal dampness and the Northwest dryness groups than the T2DM group.Additionally,the mRNA and protein levels were significantly higher in the Northwest dryness group than in the internal dampness group.CONCLUSION:Northwest dryness syndrome-mediated TLR4/MyD88/NF-κB pathway and chronic inflammation might be associated with the occurrence and development of T2DM.
基金Under the auspices of the National Natural Science Foundation of China(No.41801180)the Natural Science Basic Research Plan in Shaanxi Province of China(No.2020JQ415,2019JQ-767)。
文摘Spatio-temporal dynamic monitoring of soil moisture is highly important to management of agricultural and vegetation eco-systems.The temperature-vegetation dryness index based on the triangle or trapezoid method has been used widely in previous studies.However,most existing studies simply used linear regression to construct empirical models to fit the edges of the feature space.This requires extensive data from a vast study area,and may lead to subjective results.In this study,a Modified Temperature-Vegetation Dryness Index(MTVDI)was used to monitor surface soil moisture status using MODIS(Moderate-resolution Imaging Spectroradiometer)remote sensing data,in which the dry edge conditions were determined at the pixel scale based on surface energy balance.The MTVDI was validated by field measurements at 30 sites for 10 d and compared with the Temperature-Vegetation Dryness Index(TVDI).The results showed that the R^(2) for MTVDI and soil moisture obviously improved(0.45 for TVDI,0.69 for MTVDI).As for spatial changes,MTVDI can also better reflect the actual soil moisture condition than TVDI.As a result,MTVDI can be considered an effective method to monitor the spatio-temporal changes in surface soil moisture on a regional scale.
基金the National Natural Science Foundation of China (40461001)
文摘Moderate resolution imaging spectroradiometer （MODIS） data are very suitable for vast extent, long term and dynamic drought monitoring for its high temporal resolution, high spectral resolution and moderate spatial resolution. The composite Enhanced Vegetation Index （EVI） and composite land surface temperature （Ts） obtained from MODIS data MOD11A2 and MOD13A2 were used to construct the EVI-Ts space. And Temperature Vegetation Dryness Index （TVDI） was calculated to evaluate the agriculture drought in Guangxi province, China in October of 2006. The results showed that the drought area in Guangxi was evidently increasing and continuously deteriorating from the middle of September to the middle of November. The TVDI, coming from the EVI-Ts space, could effectively indicate the spatial distribution and temporal evolution of drought, so that it could provide a strong technical support for the forecasting agricultural drought in south China.
文摘Linear regression,climate trend rate,integral humidity indicator and dry-wet index were adopted to analyze the precipitation change,drought or waterlogging frequency and occurrence period in Benxi of Liaoning.The results showed that in recent 55 years,the tendency rate of annual precipitation in Benxi was-30.749 mm/10 a,reducing 165 mm in trend;the precipitation tendency rate during the growing season of plants was-31.371/10 a,reducing 173 mm in trend.The climate type was changed from light flood 20 a ago to wet type.The satisfaction of agriculture-required water was above 150% and annual average precipitation surplus was 290 mm.Benxi was hit by the medium floods to heavy floods in 10 years,about once in five years.The occurrence period of mild drought was 5 a,about once in ten years.The drought in spring below the medium degree occurred twice in a decade while the waterlogging above the medium degree occurred once in a decade.The waterlogging in summer above the medium degree occurred once in two years.The waterlogging in autumn above the medium degree occurred twice in a decade while the drought below the medium degree occurred four times in a decade.The occurrence frequency of heavy waterlogging in July and August was 54.5%.May and September were the period of time with a strikingly higher prevalence in drought.
文摘The Chikugo Model is used to estimate radiative dryness indexes (RDI) and net primary productivity (NPP) of vegetation zones in China by calculating cli-matic parameters. That provides the water-heat equilibrium condition, potential primary production for natural vegetation in various vegetation zones, and their geographical distribution pattern. That could be used as the basis for study the effect of global climate change on ecosystems.
基金supported by the National Key Research and Development Program of China (2016YFA0601601)National Natural Science Foundation of China (Grants Nos. U1502233,41405001)+1 种基金the Jiangsu Collaborative Innovation Center for Climate ChangePh.D. Programs Foundation of Ministry of Education of China (20135301120010)
文摘Using Moderate Resolution Imaging Spectroradiometer(MODIS) data from the dry season during 2010–2012 over the whole Yunnan Province, an improved temperature vegetation dryness index(iTVDI), in which a parabolic dry-edge equation replaces the traditional linear dry-edge equation, was developed, to reveal the regional drought regime in the dry season. After calculating the correlation coefficient, root-mean-square error, and standard deviation between the iTVDI and observed topsoil moisture at 10 and 20 cm for seven sites, the effectiveness of the new index in depicting topsoil moisture conditions was verified. The drought area indicated by iTVDI mapping was then compared with the drought-affected area reported by the local government. The results indicated that the iTVDI can monitor drought more accurately than the traditional TVDI during the dry season in Yunnan Province. Using iTVDI facilitates drought warning and irrigation scheduling, and the expectation is that this new index can be broadly applied in other areas.
文摘Objective:To study on Prof. GAO Zhong-ying’s drug selection law for treatment of chronic gastritis with data mining technique. Methods: The 407 medical records of chronic gastritis treated by Prof. GAO Zhong-ying were collected and the study on these drugs in the recipes was carried out with data mining method. Among them, the recipe composed of one drug was studied with frequency statistical method, correlativity between drug pairs with improved mutual information, correlativity among multi-drugs with complex system entropy cluster technique. Results: In treatment of chronic gastritis by Prof. GAO Zhong-ying there were 30 drugs with a higher use frequency of over 38 times, 94 commonly-used drug pairs with correlation coefficient of over 0.05, 11 commonly-used drug core combinations. Conclusion: The results attained with data mining technique for studying experience of famous and old TCM physicians conform to the clinical practice and the method is of an important significance for summarization of famous and old TCM physicians’ experiences.
基金Supported by China Postdoctoral Science Foundation:Research of Abnormal Savda Syndrome of COPD Based on the Anaysis of Mucin and Aquaporin(No.2014M562532XB)
文摘OBJECTIVE: To reveal the effects on expression of airway mucus-associated proteins in rats with chronic obstructive pulmonary disease(COPD) and a cold-dryness symptom pattern induced by elastase and smoking.METHODS: The COPD model was established with an elastase dose into the trachea combined with exposure to smoking; the COPD model cold-dryness symptom pattern was further developed by exposure to a cold, dry environment. After 90 days,pathologic lung sections, inflammatory cytokine levels(measured by enzyme linked immunosorbent assay), m RNA and protein expression of mucus-associated proteins and aquaporins(measured by real-time polymerase chain reaction and western blots) were examined.RESULTS: Cytokines interleukin-6(IL-6), interleukin-8(IL-8), and tumor necrosis factor-α(TNF-α) in the COPD and the cold-dryness symptom pattern COPD groups were all significantly higher than in controls(each P < 0.01). IL-6 and IL-8 levels were higher in the cold-dryness symptom pattern COPD group than in the COPD group(each P < 0.05). The AQP5 m RNA expression in the cold-dryness symptom pattern COPD and COPD groups was lower than in the control group(P < 0.01), and that in the cold-dryness symptom pattern COPD group was lower than the COPD group(P < 0.05). The expression of MUC5 AC and MUC5 B m RNAs in the cold-dryness symptom pattern COPD group and COPD group was higher than in the control group(each P < 0.01), and that in the cold-dryness symptom pattern COPD group was higher than the COPD group(P < 0.01, and P < 0.05, respectively).The ratio of MUC5 AC m RNA/MUC5 B m RNA was COPD group < the cold-dryness symptom pattern COPD group < the control group. AQP4 and AQP5 protein expression in the cold-dryness symptom pattern COPD group was lower than that in the COPD group which was lower again than in the control group. MUC5 AC and MUC5 B expression in the cold-dryness symptom pattern COPD group was higher than in the COPD group and higher again than in the control group.CONCLUSION: Cold-dryness affects the expression of mucus-associated protein m RNA and its corresponding proteins, reducing the secretion of aquaporins and increasing the secretion of mucins. Imbalance in aquaporins and mucins can affect the function of mucus, increasing airway obstruction.
基金Supported by Project of National Natural Science Foundation of China(2013,On the Correlation Between the Northwest Dryness Syndrome and Metabolic Syndrome and It's Relationship with PPARs Gene,No.81260518)
文摘OBJECTIVE:To investigate the relationship between gene polymorphism of peroxisome proliferator-activated receptor(PPAR) and susceptibility to northwest dryness syndrome(NDS).METHODS:The polymorphisms of 11 PPARl51, rs13γ7 gene oci rs10510418, rs1263353640,rs17036188, rs2921190, rs4135247, rs4135275,rs4135283, rs6768587, rs709156, and rs7615916 were detected in 249 patients with NDS and 260 patients with non-NDS(control group) by using Snapshot single-nucleotide polymorphism typing technology.RESULTS:All locus detections were in accordance with Hardy-Weinberg equilibrium test.Compared with the control group, rs2921190 genotype frequency showed statistical difference in the NDS group(P < 0.05).Two-two comparison result showed that CC genotype frequency in the NDS group was higher than that in the control group.CT and TT genotype distribution frequencies showed differences between the two groups.The rare allele frequency in the NDS group was lower than that of the control group(P < 0.01).Multi-factor logistic regression analysis showed that the age and genotype entered the regression equation.The subjects in the age bracket 30-55 and 45-45 were1.796 and 1.561 times likely, respectively, than those in other age brackets to contract NDS,.The patients with CC genotype was only 0.524 times likely than those with CT/TT genotype to suffer from NDS.CONCLUSION:PPARsm was correlated γw gene rs2921190 polymorphiith the susceptibility to NDS.
文摘Using indexes of dryness and wetness in historical record over the recent recent years and rainfall data over the tatest century, the work involves itself with the study of climatological evolution of dryness and wetness. periodic variations of climate and interannual laws of variation. The discussion also covers the subjects of effects of El Nino. sunspot, predictors of general circulation on climatic variation of dryness and wetness. There arc main conclusions as follows: (1) The main cyclic variations of climate are 40 and 11 years in Kunming. the former being subject to that of El Nino and the latter to that of sunspots. They are two principal factors for periodic variations of dryness and wetness in Kunming. (2) A close relationship exists between interannual variations and general circulation factors for Kunming. The comprehensive influence as imposed by ENSO and allocations of W.C.E. patterns of circulation in the westerly are ma.tor weather and climate causes for the interannual variations of precipitation in Kunming.
文摘Precipitation data from 86 observing Stations for the past four decades (from the first operational use to 1994) are used to study and discuss the character of annually mean distribution in Guangdong. Grades of dryness and wetness on a year-to-year basis are determined and preliminary features of dryness and wetness are discussed for the whole of the province and individual regions according to a 5-grade standard of division. The result has shown that there is on an average a rainfall of 1748 mm per year across the province, with four major centers of maxima (of annual rainfall over 2000 mm) at Enping, Qingyuan, Haifeng and Longmen. For the mean across the province, the years 1959. 1 961. 1973.1975, 1991 are anomalously wet and the years 1956, 1963, 1977 and 1991 are anomalously dry. of them, 1973 is the unusually wet year (with the absolute value of precipitation anomaly over twice as large as the standard deviation) and 1956 and 1963 are the usual dry years. For the occurrence frequency of unusually wetness and dryness over individual river valleys in the province, there are more years of dryness in the valleys of the Xijiang and Dongjiang Rivers. More years of wetness in that of the Jianjiang River, and only years of wetness instead of years of dryness in the valleys of Beijiang and Hanjiang Rivers.
基金Frontier Project of Nanjing Institute of Geography and Limnology,CAS, No.CXNIGLAS200814National Forestry Science and Technique Foundation during the 11th Five-Year Plan Period,No.2006BAD03A1601+1 种基金Project of Huaihe River Basin,No.HRM200708National Climate Center,China Meteorological Administration, No.CCSF2007-35
文摘Dryness and wetness variations on different time scales in Shanghai were analyzed using the Standardized Precipitation Index （SPI） based on monthly precipitation data for 1873-2005. The SPI on scales of 3, 6, 12 and 24 months has been calculated. The SPI on 3, 6, 12 and 24 months present 4 wet periods prevailed during 1873-1885, 1904-1923, 1938-1960 and 1983-2005, and 3 dry episodes during 1886-1903, 1924-1937 and 1961-1982. Significant periods of higher wavelet power in the SPI-24 months occurred on the time scales of 2-7-year band in around 1880-1890, 1910-1950 and 1970-1990, and at 8-15-year band in 1920-1960 and 1965-2000 respectively. Periodicities in the SOl and ENSO indices are similar to those in SPI-24 months with little difference, namely, in the SPI-24 months, there are significant periods at the 2-7- and 8-15-year bands during 1930-1940. The periodicity components in individual SPI-24 months, SOl and ENSO indices are more complicated, showing the wetness and dryness variability in Shanghai is controlled by more than one physical factors. The research results indicate that the Shanghai area has experienced dryness and wetness variability on different time scales during the past 133 years.
基金support provided by the National Key Research and Development Program of China(Grant No.2018YFB1501805)the National Natural Science Foundation of China(Grant No.52176183)。
文摘The Enhanced Geothermal System(EGS) is a recognized geothermal exploitation system for hot dry rock(HDR), which is a rich resource in China. In this study, a numerical simulation method is used to study the effects of geothermal fluid dryness and non-condensable gas content on the specific enthalpy of geothermal fluid. Combined with the organic Rankine cycle(ORC), a numerical model is established to ascertain the difference in power generation caused by geothermal fluid dryness and non-condensable gas content. The results show that the specific enthalpy of geothermal fluid increases with the increase of geothermal fluid temperature and geothermal fluid dryness. If the dryness of geothermal fluid is ignored, the estimation error will be large for geothermal fluid enthalpy. Ignoring non condensable gas will increase the estimation of geothermal fluid enthalpy, so the existence of the non-condensable gas tends to reduce the installed capacity of a geothermal power plant. Additionally, both mass flow of the working medium and net power output of the ORC power generation system are increased with increasing dryness of geothermal fluid, however there is some impact of geothermal fluid dryness on thermal efficiency.
文摘The aim of this study was to compare serum 17β-estradiol of menopausal women with/without Oral Dryness (OD) feeling, and evaluate the re-lationship between serum 17β-estradiol and severity of OD feeling. A case-control study was carried out on 70 selected menopausal women aged 40 - 77 years with or without OD feeling (35 as case, 35 as control) conducted at the Clinic of Oral Medicine, Tehran University of Medical Sciences. Xerostomia inventory (XI) score was used as an index of OD feeling severity. The serum 17β-estradiol concentration was measured by an enzyme immunoassay kit (ELISA). Statistical analysis of Student’s t-test and Spearman correlation coefficient was used. The mean serum concentration of 17β-estradiol was significantly lower in case than control. There was a significant negative correlation between XI score and concentration of 17β-estradiol in menopausal women (r = –0.311, P = 0.004). It seems that there is a negatively slight correlation between OD feeling severity and serum 17β-estradiol in menopausal women.
基金Supported by National Natural Science Foundation of China(31371556)Natural Science Foundation of Hainan Province(312026)Fundamental Research Fund for the Rubber Research Institute in Chinese Academy of Tropical Agricultural Sciences(1630022011014)
文摘As a syndrome with tapping incision blocked partly or entirely during latex exploiting in rubber tree （Hevea brasiliensis ）, ＂Tapping panel dryness （TPD）＂ causes great yield losses, thereby becoming the most important factor limiting rubber production. On the basis of an EST down-regulated in TPD-affected rubber trees, a 903 bp cDNA denoted HbPIP2;2 was isolated from the bark tissue with a combination of in silico cloning and RT-PCR. The cDNA contains an 867 hp ORF, 13 bp 5＇UTR and 23 bp 3＇ UTR. Sequence analysis indicated that HbPIP2;2 encodes 288 amino acids with a theoretical molecular weight （Mw） of 30. 71 kDa and isolectric point （Pi） of 8.20. Bioinformatics analysis suggested that the deduced protein is predicted to have six transmembrane helices located to the plasma membrane and harbor one conserved MIP domain that can be grouped into plasma membrane intrinsic proteins （PIPs） of aquaporin （AQP） family. Homolo- gy search revealed that the protein shares a similarity of more than 90% with the homologues in Ricinus communis, Popttlus trichocarpa, Juglans regia and Theobro- ma cacao, suooorting a hie.hly conserved evolution. This study provided basis for further uncovering the regulatory role of AOPs in TPD occurrence.
基金Supported by National Natural Science Foundation of China(31371556)Natural Science Foundation of Hainan Province(312026)Fundamental Research Fund for the Rubber Research Institute in Chinese Academy of Tropical Agricultural Sciences(1630022011014)
文摘[Objective]To address the role of aquaporins（AQPs）in the occurrence of Tapping Panel Dryness（TPD）,a phenomenon with tapping incision blocked partly or entirely during latex exploiting in the rubber tree（Hevea brasiliensis）that causes great losses on rubber production,a tonoplast aquaporin gene associated with TPD occurence was cloned and analyzed.[Method]Based on an EST down-regulated in TPD-affected rubber trees,a 774 bp cDNA designated HbTIP1 was isolated from the bark tissue of Hevea brasiliensis with a combination of in silico cloning and RT-PCR.And the gene structure and sequence characteristics were analyzed using bioinformatics tools.[Result]The cDNA includes a 759 bp ORF,8 bp 5’UTR and 7 bp 3’UTR.Sequence analysis indicated that HbTIP1putatively encodes 252 amino acids with a theoretical molecular weight（Mw）of 25.88 kDa and isolectric point（pI）of 4.96.Bioinformatics analysis suggested that the deduced protein is predicted to have six transmembrane helices located to the vacuolar membrane and to harbor one conserved MIP domain that can be grouped into the tonoplast intrinsic proteins（TIPs）of aquaporin family.Homology search revealed that the protein shares a similarity of more than 90%with the homologues in Theobroma cacao,Prunus persica,Citrus sinensis and Ricinus communis,supporting a highly conserved evolution.[Conclusion]This study provided basis for further revealing the regulatory role of AQPs in the TPD occurrence.
文摘The temperature-vegetation index space coupled with information of surface temperature and vegetation, is an important method to realize soil moisture estimation and agricultural drought monitoring. In order to estimate the soil moisture in the study area, we collected soil relative humidity of Agricultural meteorological station and downloaded Moderate Resolution Imaging Spectrometer (MODIS) image data. Then, the temperature vegetation dryness index was calculated based on the MODIS Normalized difference vegetation index (NDVI) and land surface temperature (LST). A correlation analysis of TVDI and soil relative humidity at depth of 10 cm was carried out and an empirical model of moisture estimation was established. Finally, another set of data was used to validate the accuracy of model. The results show that the TVDI method can be used to achieve the soil moisture in the study area. The empirical model has certain universality in the study area, and obtains a high accuracy of soil moisture estimation with an R2 of 0.374 and RMSE of 11.73%.
文摘Temperature sensitivity of soil respiration (Q10) is a critical parameter in carbon cycle models with important implications for climate-carbon feedbacks in the 21st century. The common assumption of a constant Q10, usually with a value of 2.0, was shown to be invalid by a previous model-data fusion study that reported biome-specific values of this parameter. We extend the previous analysis by demonstrating that these biome-level values of Q10 also are a function of dryness (R2 = 0.54). When tundra and cultivated lands are excluded, the correlation is much stronger (R2 = 0.92). Therefore dryness is the primary driver for variability in respiration-temperature sensitivity in forest and grassland ecosystems. This finding has important implications for the response of the terrestrial carbon cycle to climate change, as it implies that the increasing dryness would potentially accelerate the respiration temperature sensitivity feedback.
文摘In the study, we report the comparative efficacy of the sodium hyaluronate gel vaginal application and promestriene cream which were tested to treat the gynecological symptoms of people who suffered from vaginal dryness. Method: 35 patients applied sodium hyaluronate vaginal gel one time a day for a period of two times a week during three weeks and other 33 patients using promestriene cream applied it every day for a period of three weeks also. Results: No significant difference was observed between vaginal application of sodium hyaluronate gel and promestriene cream, regarding both, as regarding the dryness of the intimate mucosa (p = 0.786), the attribute of moisturizing properties to the intimate mucosa (p = 0.142), the comfort sensation (p = 0.528), and no significant difference was observed regarding the fragrance of the product (p = 0.088). Conclusion: The similar results between vaginal application of both products support the use of sodium hyaluronate vaginal gel (Lubrinat®) in the initial approach of symptoms of vaginal dryness.
