This work presents a study of the Paleogene sandstones of the Manika plateau in Kolwezi, DR Congo. These sandstones belong to the “Grès polymorphes” group, which together with the overlying “Sables ocre” make...This work presents a study of the Paleogene sandstones of the Manika plateau in Kolwezi, DR Congo. These sandstones belong to the “Grès polymorphes” group, which together with the overlying “Sables ocre” makes up the Kalahari Supergroup. Sedimentological and geochemical analyses have enabled us to characterize these sandstones and determine their origin, the conditions of their formation and the tectonic context in which they were developed. The results show that the sandstones are quartz arenites with a high level of mineralogical, textural and chemical maturity. They are recycled sandstones, formed in an intracratonic sedimentary basin, in the context of a passive continental margin, after a long fluvial transport of sediments. These sandstones initially come from intense alteration of magmatic rocks with felsic composition, mainly tonalite-trondhjemite-granodiorite (TTG) complexes, in hot, humid palaeoclimatic conditions and oxidizing environments.展开更多
The Makiso municipality is located in an urban area influenced by a very high rate of land occupation by houses. This land use has an impact on the quality of the groundwater exploited by wells and springs. This groun...The Makiso municipality is located in an urban area influenced by a very high rate of land occupation by houses. This land use has an impact on the quality of the groundwater exploited by wells and springs. This groundwater helps to make up for the deficit caused by the lack of a water distribution network. It is also threatened by pollution from human activities. In order to protect the groundwater in Makiso municipality from pollution, the study of the intrinsic vulnerability assessment in the aquifers was carried out by applying the DRASTIC method and the Geographic Information System (GIS). The results obtained using this method were grouped into two degrees of vulnerability (medium and high), with variations in DRASTIC indices of [141 - 145] for the medium degree and [146 - 175] for the high degree. The high vulnerability class is the most dominant, with a percentage of 96.5% of the study area. The medium vulnerability class, which represents 3.5% of the area of the Makiso municipality, is mainly located in the western (medical plateau district), central (Lualaba district) and southern (commercial district) sectors in the form of isolated pockets. A comparison of the nitrate distribution map with the final vulnerability map shows that the areas defined as highly vulnerable by the DRASTIC method and the areas with high nitrate concentrations (above 0.11 mg/l) are in agreement. On the other hand, there are other areas with low nitrate concentrations (below 0.05 mg/l) which correspond to the high vulnerability indices.展开更多
Background: Continuous spinal anesthesia (CSA) is an underused technique in modern anesthesia practice. Compared with other techniques of neuraxial anesthesia, CSA allows incremental dosing of an intrathecal local ane...Background: Continuous spinal anesthesia (CSA) is an underused technique in modern anesthesia practice. Compared with other techniques of neuraxial anesthesia, CSA allows incremental dosing of an intrathecal local anesthetic for an indefinite duration, whereas traditional single-shot spinal anesthesia (SSA) usually involves larger doses, a finite, unpredictable duration, and greater potential for detrimental hemodynamic effects including hypotension, and epidural anesthesia via a catheter may produce lesser motor block and suboptimal anesthesia in sacral nerve root distributions. It is indicated in elderly patients undergoing lower limbs and sub umbilical surgery. Aim: This work aims to highlight the advantages of CSA on hemodynamic stability and as an alternative to heavy anesthetic procedures in already fragile patients. Case presentation: Our cases were two elderly patients, both of them with past stories of cardiac diseases. Both of them were undergoing amputation indicated for wet gangrene on lower limbs. They had unstable hemodynamics states due to inflammatory state. They were all rated ASA 3. CSA was performed with low doses of local anesthetics and maintenance by reinjections of mixture with the same doses. The interventions took place without major incidents and all patients survived. Conclusion: CSA is an underused technique in modern anesthesia. However, there is renewed interest due to the quality of the blocs and the hemodynamics stability. We report a case series of 2 elderly patients with past stories of cardiac diseases undergoing amputation for dry gangrene that had been operated under CSA.展开更多
Malaria,for its high prevalence and morbidity,is one of the major tropical parasitic diseases,particularly in DR Congo.Its therapy not only uses modem antimalarials,for which many Resistance problems are encountered,b...Malaria,for its high prevalence and morbidity,is one of the major tropical parasitic diseases,particularly in DR Congo.Its therapy not only uses modem antimalarials,for which many Resistance problems are encountered,but also medicinal plants which are promising sources for new and effective antimalarials.This study was conducted展开更多
In the Democratic Republic of Congo,the Kafubu River has received,for several decades,mining waste from GECAMINE Kipushi and Lubumbashi as well as those from the CHEMAF plant.Given this situation,we wanted to verify t...In the Democratic Republic of Congo,the Kafubu River has received,for several decades,mining waste from GECAMINE Kipushi and Lubumbashi as well as those from the CHEMAF plant.Given this situation,we wanted to verify the degree of contamination of fish in the Kafubu River with TME(Trace Metal Elements).In doing so,fish samples from this river,downstream of mining activities,as well as samples of reference fish from upstream of any mining activity from the sources of the Panda and Kasungwe rivers and that of the Congo River were analyzed with Inductively Couple Plasma Mass Spectrometry(ICP-MS)and Inductively Couple Plasma Optical Emission Spectroscopy(ICP-OES).Statistical analysis,using the Wilcoxon test,of the results obtained as well as the comparison of these with the thresholds of the WHO(World Health Organization),FAO(Food and Agriculture Organization)and the EU(European Union)revealed that the fish of the Kafubu River are contaminated with As,Cd,Co,Cu,Mn,Ni,Pb,Se and Zn.Thus,it was concluded that the fish of the Kafubu River were not fit for human consumption.In addition,because of the very high level of bioaccumulation of these TMEs in the fish of the Kafubu River,the latter have been described as poisonous for the consuming population.The main principle that emerges from this study is that fish from an ecosystem polluted by mining waste are not fit for human consumption.The results of this study will be brought to the attention of Decision-makers in the Haut-Katanga Province so that rigorous measures can be taken to prohibit metallurgical plants from dumping their mining waste into aquatic ecosystems.展开更多
African Cassava mosaic disease (ACMD) is the most severe and widespread disease caused by viruses limiting production of the crop in sub-Saharan Africa. The objective of the present study was to evaluate CMD incidence...African Cassava mosaic disease (ACMD) is the most severe and widespread disease caused by viruses limiting production of the crop in sub-Saharan Africa. The objective of the present study was to evaluate CMD incidence, severity, and gravity under different agro-environmental conditions. A total of 222 fields were surveyed in 23 different locations. All the farmers grow only local cassava varieties without applications of fertilizers. Overall, mean CMD incidences for all sites surveyed were 58.2% and 51.7%, in 2009 and 2010, respectively. Disease severity ranged from 2.4 to 3.1 on a scale of 1 to 5. Mean disease gravity varied from 29.7% to 62%, in 2010, and 2009, respectively. Detailed analysis of agronomic and environmental revealed no significant association between cassava stand locations, age, land topography and the development of CMD. Likewise intercropping practices and field topping did not affect the development of CMD in all the fields surveyed. There were significant differences in the number of white flies (Bemisia tabaci) per plant in 2009 and 2010, but no significant correlations between the number of B. tabaci per plant and CMD incidence, severity, and gravity was found. In most fields, CMD appears to originate mostly from unhealthy cassava cuttings used for planting.展开更多
Background: For countries with limited resources such as the Democratic Republic of the Congo (DRC), the diagnosis of Multidrug-resistant tuberculosis (MDR-TB) is still insufficient. The MDR-TB identification is done ...Background: For countries with limited resources such as the Democratic Republic of the Congo (DRC), the diagnosis of Multidrug-resistant tuberculosis (MDR-TB) is still insufficient. The MDR-TB identification is done primarily among at-risk groups. The knowledge of the true extent of the MDR-TB remains a major challenge. This study tries to determine the proportion of MDR-TB in each group of presumptive MDR-TB patients and to identify some associated factors. Methods: This is an analysis of the DRC surveillance between 2007 and 2016. The proportions were expressed in Percentage. The logistic regression permits to identify the associated factors with the RR-/MDR-TB with adjusted Odds-ratio and 95% CI. Significance defined as p ≤ 0.05. Results: Overall, 83% (5407/6512) of the MDR-TB presumptive cases had each a TB test. 86.5% (4676/5407) had each a culture and drug sensitive testing (DST) on solid medium, and 24.3% (1312/5407) had performed an Xpert MTB/RIF test. The proportion of those with at least one first-line drug resistance was 59.3% [95% CI 57.2 - 61.4] among which 50.1%, [95% CI 47.9 - 52.3] for the isoniazid, 45.6% [95% CI 43.4 - 47.8] for the rifampicin, 49.9% [95% CI 47.8 - 52.1] for ethambutol and 35.8% [95% CI 33.7 - 37.9] for streptomycin. The confirmation of MDR-TB was 42.8% [95% CI 38.4 - 47.8]. Combining both tests, the proportion of RR-/MDR-TB was 49.6% [95% CI 47.9 - 51.4] for all presumptives. This proportion was 60.0% for failures, 40.7% for relapses and 34.7% for defaulters. Associated factors with the diagnosis of MDR-TB were: aged less than 35 years;prior treatment failure;defaulters;the delay between the collection of sputum and the test completion. Conclusion: The proportion of RR-/MDR-TB among the presumptives has been higher than those estimated generally. The National tuberculosis programme (NTP) should improve patient follow-up to reduce TB treatment failures and defaulting. Moreover, while increasing the use of molecular tests, they should reduce sample delivery times when they use culture and DST concomitantly.展开更多
The responses of eight genetically improved and eight local cassava varieties to cassava mosaic disease (CMD) were evaluated under field conditions at two sites, in Eastern Kasa?, region of the DR-Congo). The varietie...The responses of eight genetically improved and eight local cassava varieties to cassava mosaic disease (CMD) were evaluated under field conditions at two sites, in Eastern Kasa?, region of the DR-Congo). The varieties were planted using randomized complete block design with three replications. The rate of cuttings sprouted varied significantly from variety to variety and from location to location. Local varieties were severely infected than improved varieties throughout the trial period. In general, the level of CMD incidence for genetically improved varieties was below 15% while it reached 100% for the local cassava varieties six months after planting (MAP). This trend was also observed for the CMD severity and gravity. The mean scores for CMD severity were 2 and 3.6 for genetically improved and local varieties, respectively at 6 MAP. CMD gravity for improved varieties was below 21% for genetically improved varieties and exceeded 85% for local varieties at the end of trials. Area Under the Severity index Progress Curve (AUSiPC) and Area Under Disease Progress Curve (AUDPC) estimates confirmed that improved varieties were moderately infested comparatively to local varieties. Molecular analysis is being conducted to determine the genetic variability and complexity of the cassava mosaic virus strains involved.展开更多
Maize production in tropical Africa is often negatively affected by drought. The main objectives of the present study were to 1) analyze the impact of water stress on the agro-morphological performance of two varietie...Maize production in tropical Africa is often negatively affected by drought. The main objectives of the present study were to 1) analyze the impact of water stress on the agro-morphological performance of two varieties of Quality Protein Maize (QPM) compared to two normal maize varieties and 2) assess their adaptive response in contrasting water environments. Agro-morphological responses to water deficiency of maize (Zea mays L.) were assessed in controlled experiments using four maize varieties, two normal maize (Zm725 and Mus1) and two quality protein maize (Mudishi1 and Mudishi3) varieties. They were subjected to three water regimes (100%, 60%, 30% water retention capacity) at the beginning of the bloom stage, using a Fischer block design with four replications. Significant differences (p < 0.05) among varieties, water regimes and their interactions for plant growth and production parameters were observed. Reduction of water supply to plants caused changes in aerial and underground plant growth. Plant stem height, foliar expansion, and root system development characterizing vegetative growth showed variation in varietal response to water regimes. Mus1 (normal maize variety) was the best adapted to variations in water regimes because they developed an important root volume to adapt to the effects of water deficit while maintaining their morphological and productive characteristics.展开更多
Arsenic,barium,bismuth,cadmium,cesium,chromium,cobalt,copper,iron,lead,manganese,molybdenum,nickel,strontium,thallium,tungsten,uranium,vanadium,and zinc concentrations were investigated in forty-two groundwater sample...Arsenic,barium,bismuth,cadmium,cesium,chromium,cobalt,copper,iron,lead,manganese,molybdenum,nickel,strontium,thallium,tungsten,uranium,vanadium,and zinc concentrations were investigated in forty-two groundwater samples,twenty-four surface water and six surface sediment samples in Kinsevere industrial zone and its surroundings in February and march 2017,January,February and March 2018 to evaluate the potential human health risk.Chemical analyses were carried out by using ICP-SF-MS(Inductively Coupled Plasma-Sector Field Mass Spectrometry,Thermo Scientific Element II).The trace metals were detected at various concentrations in all the analyzed samples.Pb,Mn and Fe concentrations exceeded the European Union acceptable maximum limits for water intended for human consumption in 4.76%,28.57%and 61.90%of the groundwater samples,respectively and in 0%,50%and 100%of the surface water samples,respectively.As,Cr,Cu and Ni concentrations exceeded the recommended lower sediment quality guideline values in 33.33%,50%,83.33%and 83.33%of the surface sediment samples,respectively.All those elevated trace metal concentrations in the groundwater,surface water and sediments represent a risk for the health of local population as well as for aquatic organisms.展开更多
<strong>Background: </strong>Happy hypoxia is a new feature found in COVID-19 patients. It consists of the presence of severe hypoxemia but normal breathing rate. Failure to identify this hypoxia may have ...<strong>Background: </strong>Happy hypoxia is a new feature found in COVID-19 patients. It consists of the presence of severe hypoxemia but normal breathing rate. Failure to identify this hypoxia may have negative consequences on the survival of the patient. The objective of the present study was to measure the frequency of patients with happy hypoxia and to evaluate their survival at the Kinshasa University Hospital (KUH). <strong>Methods: </strong>This was a historical cohort of 141 hospitalized patients with COVID-19 at KUH from March 23 to June 15, 2020. Happy hypoxia was defined as oxygen saturation below 90% without dyspnea. Socio-demographic data, co-morbidities, follow up time of hospitalization and outcomes were studied. Survival was assessed using the Kaplan Meier curve. <strong>Results:</strong> Out of 141 hospitalized patients with COVID-19, 79 (56%) patients were at the severe or critical stage and 9 (6.4%) had a happy hypoxia on admission. Patients who had happy hypoxia on admission were generally older than 60 years of age (55.6%) (p = 0.023). Comparison of survival curves, based on the presence or absence of happy hypoxia, shows a statistically significant difference (p = 0.001). The presence of happy hypoxia reduces survival. <strong>Conclusion:</strong> The frequency of happy hypoxia among COVID-19 patients was low. Survival was reduced in patients with happy hypoxia. Prehospital pulse oximetry could serve as an early warning signal for the detection of happy hypoxemia in COVID-19 patients.展开更多
Prunus africana is a species of great economic, medicinal and ecological importance. Due to its multiple uses, unsustainable exploitation methods and low regeneration capacity in tropical rainforests, this species is ...Prunus africana is a species of great economic, medicinal and ecological importance. Due to its multiple uses, unsustainable exploitation methods and low regeneration capacity in tropical rainforests, this species is threatened with extinction. Present and exploited in the eastern part of DR Congo, knowledge of the dynamics of post-bark regeneration of Prunus africana remains fragmentary and poorly known. In North Kivu province, this species thrives in both afromontane forest and lowland tropical rainforest habitats. In order to contribute to the rational and sustainable exploitation of Prunus africana in this province, this paper was carried out with the objective of contributing to the knowledge of the dynamics of the regeneration of post-harvest bark of Prunus africana in two exploitation sites (low and high altitude). To achieve this objective, the inventory was conducted on 16 plots of 25 hectares each, with 8 plots per site. Dendrometric parameters (diameter at breast height (DBH), total tree height) and tree growth and regeneration parameters, i.e., stem bark thickness of the unharvested and harvested portions of the trees (bark reconstitution) were measured. A total of 716 barked stems of Prunus africana in 2016 in 25 hectares constituted the study sample. Results show that sites do not influence diameter at breast height of P. africana trees (p > 0.05) or total tree height. The bark diameter of harvested trees and the bark diameter of unharvested trees varied significantly by site (p 0.05). In contrast, the annual growth rate of bark differed with altitude;the highest rate was observed in trees growing at high altitude (2.97 ± 0.9 mm/yr) compared to 2.23 ± 0.74 mm/yr at low altitude. In view of these results, this study indicates that a half-rotation of 7 years could allow an effective reconstitution of the bark of Prunus africana at the second passage on the remaining side of the same stem.展开更多
Cassava bacterial blight (CBB) caused by Xanthomonas axonopodis pv. manihotis has been reported in several African countries since 1970. Knowledge of the virulence and diversity of Xanthomonas axonopodis pv. manihotis...Cassava bacterial blight (CBB) caused by Xanthomonas axonopodis pv. manihotis has been reported in several African countries since 1970. Knowledge of the virulence and diversity of Xanthomonas axonopodis pv. manihotis strains is important for an integrated control of CBB. The main objective of the present study was to characterize strains of Xanthomonas axonopodis collected from various regions in the DR-Congo. There was variability among strains for shape (form), contour (margin) and elevation. Bacterial cell size for the strains analyzed varied from 24.1 μm × 11.3 μm to 11.4 μm × 4.2 μm. All the Xanthomonas axonopodis pv. manihotis strains but one was motile. Two distinctive groups were identified based on radial growth of their colonies. The first group grows faster (7.8-10.5 mm/d) compared to the second group (4.8-6.9 mm/d). Five strains (Gandajika, Inera/Stat, Kansasa, Mulumba and Musakatshi) were classified as virulent with a damage rating ≤ 1 and four were aggressive (Luputa, M'vuazi, Boketa and Kiyaka) with a damage rating > 1. Significant differences were also observed among strains for disease onset, incidence and plant mortality. The highest incidence (33%) of bacterial blight 21 days after infestation (DAI) resulted from the Boketa strain inoculation and the lowest (0 % disease incidence) from INERA/STAT and Musakatshi strains. There was no clear association between geographic origin of the strains and their aggressiveness.展开更多
Setting: Provincial General Reference Hospital of Bukavu, General Reference Hospital of Panzi, General Reference Hospital of Ciriri, General Reference Hospital of Nyatende and Biopharm Hospital Center. Objective: Cont...Setting: Provincial General Reference Hospital of Bukavu, General Reference Hospital of Panzi, General Reference Hospital of Ciriri, General Reference Hospital of Nyatende and Biopharm Hospital Center. Objective: Contribute to the improvement of the anesthetic ECP of patients benefiting from MVA for incomplete abortion, Describe the methodology used for adoption of the dosage formula in Anesthesia for MVA, present the mathematical demonstration leading to the dosage formula in anesthesia for MVA. Materials and Methods: Our study was descriptive by mathematical demonstration of obtaining the equilibrium constant of the dosage formula of bipuvacaine 0.1% and Fentanyl 50 µg% adapted to the weight and specific size of patients treated anesthetically in MVA cases for incomplete abortion. We also carried out an operational research by first determining the interval where our equilibrium constant is included and secondly by means of the ends of the intervals found correlated to the ends of intervals of possible weights and sizes in the being normal human female of childbearing age to arrive at the real numerical value of the equilibrium constant of the BUKAVU Dosage Formula in the case of anesthesia for MVA during the management of incomplete abortions. Results: TWO-STAGE OPERATIONAL RESEARCH: • Determination of the interval where the equilibrium constant x = −0.95 x x by crossing the means between the extremes of volumes of anesthetic drugs giving a satisfactory sensory block without hemodynamic disturbance and the extremes of normal weight and height for women of childbearing age. We ended up with X = 0.37. Conclusion: At the end of our study which had the general objectives of contributing to the improvement of the anesthetic PEC of patients receiving MVA for incomplete abortion and specific objectives of describing the methodology used for adoption of the dosage formula in Anesthesia for MVA and present the mathematical demonstration which resulted in the dosage formula in nesthesia for MVA, it appears that the dosage formula of Bukavu, in case of intrathecal spinal analgesia of MVA for incomplete abortion provides precision on the specificity of the doses of bipuvacaine hypobarre 0.1% and Fentanyl 50 µg% reported to each patient according to her weight and height. Its application could therefore reduce morbidity and mortality and improve patient-practitioner comfort in the event of MVA for incomplete abortion following the dosage precision it provides.展开更多
Pharmaceutical counterfeiting is a health scourge responsible for several cases of morbidity and mortality. Counterfeit medicines cause therapeutic failure, emergence of resistance in the treatment of infections. This...Pharmaceutical counterfeiting is a health scourge responsible for several cases of morbidity and mortality. Counterfeit medicines cause therapeutic failure, emergence of resistance in the treatment of infections. This study was conducted in order to identify counterfeit and authentic medicines in circulation in Lubumbashi. The study included artemether and artesunate for oral administration. A careful visual inspection of medicine, investigation of authenticity of pharmaceutical products from manufacturers and pharmaceutical regulatory authorities and determination of content were used as study parameters. 52 samples: 37 artemether and 15 of artésunate were collected. 7 samples (13%) have proven to be counterfeit. Artemether was the most counterfeit (71%) and 29% for artesunate. 6 (12%) samples were substandard according to the international pharmacopoeia in terms of content of active ingredient. Sixty-seven percent of non-compliance concerned counterfeit medicines. The proportion of non-compliance is highest among counterfeit medicines (71.43% vs 2.22%;p = 0.000004). It is obvious that strengthening the capacity of the drug regulatory authority of the DRC reduces the influx of counterfeit drug and substandard.展开更多
Mutation breeding in crop plants is an effective approach in improvement of crop having narrow genetic base such as soybean. The main objective of the present study is to determine the effect of different doses of gam...Mutation breeding in crop plants is an effective approach in improvement of crop having narrow genetic base such as soybean. The main objective of the present study is to determine the effect of different doses of gamma irradiation on different morpho-agronomic characteristics. Agronomic traits that were analyzed included;grain yield, number of pods/plant, number of seeds/plant and weight of 100 seeds and numbers of days to 50% flowering. Morphometric characterization of the descriptive data included plant height, stem diameter, number of leaves/plant, leaflet length, leaflet width, number of ramifications/plant, and pod length and width at 3 lodge stage. The results of the present study revealed that the two gamma irradiation doses used (0.2 kGy and 0.4 kGy) decreased significantly most of agronomic and morphological traits evaluated in M1 populations. Different effects of 0.2 kGy and 0.4 kGy irradiation were observed in M2 populations with significant increase of grain yields and yield components in all the three soybean varieties. In general, a significant decrease or no changes of morphological traits were observed for the two irradiation doses in M2 populations. The levels of changes varied among varieties. Potential high yielding mutants were identified in progenies of irradiated seeds.展开更多
文摘This work presents a study of the Paleogene sandstones of the Manika plateau in Kolwezi, DR Congo. These sandstones belong to the “Grès polymorphes” group, which together with the overlying “Sables ocre” makes up the Kalahari Supergroup. Sedimentological and geochemical analyses have enabled us to characterize these sandstones and determine their origin, the conditions of their formation and the tectonic context in which they were developed. The results show that the sandstones are quartz arenites with a high level of mineralogical, textural and chemical maturity. They are recycled sandstones, formed in an intracratonic sedimentary basin, in the context of a passive continental margin, after a long fluvial transport of sediments. These sandstones initially come from intense alteration of magmatic rocks with felsic composition, mainly tonalite-trondhjemite-granodiorite (TTG) complexes, in hot, humid palaeoclimatic conditions and oxidizing environments.
文摘The Makiso municipality is located in an urban area influenced by a very high rate of land occupation by houses. This land use has an impact on the quality of the groundwater exploited by wells and springs. This groundwater helps to make up for the deficit caused by the lack of a water distribution network. It is also threatened by pollution from human activities. In order to protect the groundwater in Makiso municipality from pollution, the study of the intrinsic vulnerability assessment in the aquifers was carried out by applying the DRASTIC method and the Geographic Information System (GIS). The results obtained using this method were grouped into two degrees of vulnerability (medium and high), with variations in DRASTIC indices of [141 - 145] for the medium degree and [146 - 175] for the high degree. The high vulnerability class is the most dominant, with a percentage of 96.5% of the study area. The medium vulnerability class, which represents 3.5% of the area of the Makiso municipality, is mainly located in the western (medical plateau district), central (Lualaba district) and southern (commercial district) sectors in the form of isolated pockets. A comparison of the nitrate distribution map with the final vulnerability map shows that the areas defined as highly vulnerable by the DRASTIC method and the areas with high nitrate concentrations (above 0.11 mg/l) are in agreement. On the other hand, there are other areas with low nitrate concentrations (below 0.05 mg/l) which correspond to the high vulnerability indices.
文摘Background: Continuous spinal anesthesia (CSA) is an underused technique in modern anesthesia practice. Compared with other techniques of neuraxial anesthesia, CSA allows incremental dosing of an intrathecal local anesthetic for an indefinite duration, whereas traditional single-shot spinal anesthesia (SSA) usually involves larger doses, a finite, unpredictable duration, and greater potential for detrimental hemodynamic effects including hypotension, and epidural anesthesia via a catheter may produce lesser motor block and suboptimal anesthesia in sacral nerve root distributions. It is indicated in elderly patients undergoing lower limbs and sub umbilical surgery. Aim: This work aims to highlight the advantages of CSA on hemodynamic stability and as an alternative to heavy anesthetic procedures in already fragile patients. Case presentation: Our cases were two elderly patients, both of them with past stories of cardiac diseases. Both of them were undergoing amputation indicated for wet gangrene on lower limbs. They had unstable hemodynamics states due to inflammatory state. They were all rated ASA 3. CSA was performed with low doses of local anesthetics and maintenance by reinjections of mixture with the same doses. The interventions took place without major incidents and all patients survived. Conclusion: CSA is an underused technique in modern anesthesia. However, there is renewed interest due to the quality of the blocs and the hemodynamics stability. We report a case series of 2 elderly patients with past stories of cardiac diseases undergoing amputation for dry gangrene that had been operated under CSA.
文摘Malaria,for its high prevalence and morbidity,is one of the major tropical parasitic diseases,particularly in DR Congo.Its therapy not only uses modem antimalarials,for which many Resistance problems are encountered,but also medicinal plants which are promising sources for new and effective antimalarials.This study was conducted
文摘In the Democratic Republic of Congo,the Kafubu River has received,for several decades,mining waste from GECAMINE Kipushi and Lubumbashi as well as those from the CHEMAF plant.Given this situation,we wanted to verify the degree of contamination of fish in the Kafubu River with TME(Trace Metal Elements).In doing so,fish samples from this river,downstream of mining activities,as well as samples of reference fish from upstream of any mining activity from the sources of the Panda and Kasungwe rivers and that of the Congo River were analyzed with Inductively Couple Plasma Mass Spectrometry(ICP-MS)and Inductively Couple Plasma Optical Emission Spectroscopy(ICP-OES).Statistical analysis,using the Wilcoxon test,of the results obtained as well as the comparison of these with the thresholds of the WHO(World Health Organization),FAO(Food and Agriculture Organization)and the EU(European Union)revealed that the fish of the Kafubu River are contaminated with As,Cd,Co,Cu,Mn,Ni,Pb,Se and Zn.Thus,it was concluded that the fish of the Kafubu River were not fit for human consumption.In addition,because of the very high level of bioaccumulation of these TMEs in the fish of the Kafubu River,the latter have been described as poisonous for the consuming population.The main principle that emerges from this study is that fish from an ecosystem polluted by mining waste are not fit for human consumption.The results of this study will be brought to the attention of Decision-makers in the Haut-Katanga Province so that rigorous measures can be taken to prohibit metallurgical plants from dumping their mining waste into aquatic ecosystems.
文摘African Cassava mosaic disease (ACMD) is the most severe and widespread disease caused by viruses limiting production of the crop in sub-Saharan Africa. The objective of the present study was to evaluate CMD incidence, severity, and gravity under different agro-environmental conditions. A total of 222 fields were surveyed in 23 different locations. All the farmers grow only local cassava varieties without applications of fertilizers. Overall, mean CMD incidences for all sites surveyed were 58.2% and 51.7%, in 2009 and 2010, respectively. Disease severity ranged from 2.4 to 3.1 on a scale of 1 to 5. Mean disease gravity varied from 29.7% to 62%, in 2010, and 2009, respectively. Detailed analysis of agronomic and environmental revealed no significant association between cassava stand locations, age, land topography and the development of CMD. Likewise intercropping practices and field topping did not affect the development of CMD in all the fields surveyed. There were significant differences in the number of white flies (Bemisia tabaci) per plant in 2009 and 2010, but no significant correlations between the number of B. tabaci per plant and CMD incidence, severity, and gravity was found. In most fields, CMD appears to originate mostly from unhealthy cassava cuttings used for planting.
文摘Background: For countries with limited resources such as the Democratic Republic of the Congo (DRC), the diagnosis of Multidrug-resistant tuberculosis (MDR-TB) is still insufficient. The MDR-TB identification is done primarily among at-risk groups. The knowledge of the true extent of the MDR-TB remains a major challenge. This study tries to determine the proportion of MDR-TB in each group of presumptive MDR-TB patients and to identify some associated factors. Methods: This is an analysis of the DRC surveillance between 2007 and 2016. The proportions were expressed in Percentage. The logistic regression permits to identify the associated factors with the RR-/MDR-TB with adjusted Odds-ratio and 95% CI. Significance defined as p ≤ 0.05. Results: Overall, 83% (5407/6512) of the MDR-TB presumptive cases had each a TB test. 86.5% (4676/5407) had each a culture and drug sensitive testing (DST) on solid medium, and 24.3% (1312/5407) had performed an Xpert MTB/RIF test. The proportion of those with at least one first-line drug resistance was 59.3% [95% CI 57.2 - 61.4] among which 50.1%, [95% CI 47.9 - 52.3] for the isoniazid, 45.6% [95% CI 43.4 - 47.8] for the rifampicin, 49.9% [95% CI 47.8 - 52.1] for ethambutol and 35.8% [95% CI 33.7 - 37.9] for streptomycin. The confirmation of MDR-TB was 42.8% [95% CI 38.4 - 47.8]. Combining both tests, the proportion of RR-/MDR-TB was 49.6% [95% CI 47.9 - 51.4] for all presumptives. This proportion was 60.0% for failures, 40.7% for relapses and 34.7% for defaulters. Associated factors with the diagnosis of MDR-TB were: aged less than 35 years;prior treatment failure;defaulters;the delay between the collection of sputum and the test completion. Conclusion: The proportion of RR-/MDR-TB among the presumptives has been higher than those estimated generally. The National tuberculosis programme (NTP) should improve patient follow-up to reduce TB treatment failures and defaulting. Moreover, while increasing the use of molecular tests, they should reduce sample delivery times when they use culture and DST concomitantly.
文摘The responses of eight genetically improved and eight local cassava varieties to cassava mosaic disease (CMD) were evaluated under field conditions at two sites, in Eastern Kasa?, region of the DR-Congo). The varieties were planted using randomized complete block design with three replications. The rate of cuttings sprouted varied significantly from variety to variety and from location to location. Local varieties were severely infected than improved varieties throughout the trial period. In general, the level of CMD incidence for genetically improved varieties was below 15% while it reached 100% for the local cassava varieties six months after planting (MAP). This trend was also observed for the CMD severity and gravity. The mean scores for CMD severity were 2 and 3.6 for genetically improved and local varieties, respectively at 6 MAP. CMD gravity for improved varieties was below 21% for genetically improved varieties and exceeded 85% for local varieties at the end of trials. Area Under the Severity index Progress Curve (AUSiPC) and Area Under Disease Progress Curve (AUDPC) estimates confirmed that improved varieties were moderately infested comparatively to local varieties. Molecular analysis is being conducted to determine the genetic variability and complexity of the cassava mosaic virus strains involved.
文摘Maize production in tropical Africa is often negatively affected by drought. The main objectives of the present study were to 1) analyze the impact of water stress on the agro-morphological performance of two varieties of Quality Protein Maize (QPM) compared to two normal maize varieties and 2) assess their adaptive response in contrasting water environments. Agro-morphological responses to water deficiency of maize (Zea mays L.) were assessed in controlled experiments using four maize varieties, two normal maize (Zm725 and Mus1) and two quality protein maize (Mudishi1 and Mudishi3) varieties. They were subjected to three water regimes (100%, 60%, 30% water retention capacity) at the beginning of the bloom stage, using a Fischer block design with four replications. Significant differences (p < 0.05) among varieties, water regimes and their interactions for plant growth and production parameters were observed. Reduction of water supply to plants caused changes in aerial and underground plant growth. Plant stem height, foliar expansion, and root system development characterizing vegetative growth showed variation in varietal response to water regimes. Mus1 (normal maize variety) was the best adapted to variations in water regimes because they developed an important root volume to adapt to the effects of water deficit while maintaining their morphological and productive characteristics.
基金This study was carried out in the framework of the research project entitled“Assessing and Mapping the Environmental and Health Impacts of Abandoned and Ongoing Mining Activities in Lubumbashi and Its Neighborhood,Democratic Republic of Congo”with UNESCO-Sida Project funds(Contract No.4500309530).
文摘Arsenic,barium,bismuth,cadmium,cesium,chromium,cobalt,copper,iron,lead,manganese,molybdenum,nickel,strontium,thallium,tungsten,uranium,vanadium,and zinc concentrations were investigated in forty-two groundwater samples,twenty-four surface water and six surface sediment samples in Kinsevere industrial zone and its surroundings in February and march 2017,January,February and March 2018 to evaluate the potential human health risk.Chemical analyses were carried out by using ICP-SF-MS(Inductively Coupled Plasma-Sector Field Mass Spectrometry,Thermo Scientific Element II).The trace metals were detected at various concentrations in all the analyzed samples.Pb,Mn and Fe concentrations exceeded the European Union acceptable maximum limits for water intended for human consumption in 4.76%,28.57%and 61.90%of the groundwater samples,respectively and in 0%,50%and 100%of the surface water samples,respectively.As,Cr,Cu and Ni concentrations exceeded the recommended lower sediment quality guideline values in 33.33%,50%,83.33%and 83.33%of the surface sediment samples,respectively.All those elevated trace metal concentrations in the groundwater,surface water and sediments represent a risk for the health of local population as well as for aquatic organisms.
文摘<strong>Background: </strong>Happy hypoxia is a new feature found in COVID-19 patients. It consists of the presence of severe hypoxemia but normal breathing rate. Failure to identify this hypoxia may have negative consequences on the survival of the patient. The objective of the present study was to measure the frequency of patients with happy hypoxia and to evaluate their survival at the Kinshasa University Hospital (KUH). <strong>Methods: </strong>This was a historical cohort of 141 hospitalized patients with COVID-19 at KUH from March 23 to June 15, 2020. Happy hypoxia was defined as oxygen saturation below 90% without dyspnea. Socio-demographic data, co-morbidities, follow up time of hospitalization and outcomes were studied. Survival was assessed using the Kaplan Meier curve. <strong>Results:</strong> Out of 141 hospitalized patients with COVID-19, 79 (56%) patients were at the severe or critical stage and 9 (6.4%) had a happy hypoxia on admission. Patients who had happy hypoxia on admission were generally older than 60 years of age (55.6%) (p = 0.023). Comparison of survival curves, based on the presence or absence of happy hypoxia, shows a statistically significant difference (p = 0.001). The presence of happy hypoxia reduces survival. <strong>Conclusion:</strong> The frequency of happy hypoxia among COVID-19 patients was low. Survival was reduced in patients with happy hypoxia. Prehospital pulse oximetry could serve as an early warning signal for the detection of happy hypoxemia in COVID-19 patients.
文摘Prunus africana is a species of great economic, medicinal and ecological importance. Due to its multiple uses, unsustainable exploitation methods and low regeneration capacity in tropical rainforests, this species is threatened with extinction. Present and exploited in the eastern part of DR Congo, knowledge of the dynamics of post-bark regeneration of Prunus africana remains fragmentary and poorly known. In North Kivu province, this species thrives in both afromontane forest and lowland tropical rainforest habitats. In order to contribute to the rational and sustainable exploitation of Prunus africana in this province, this paper was carried out with the objective of contributing to the knowledge of the dynamics of the regeneration of post-harvest bark of Prunus africana in two exploitation sites (low and high altitude). To achieve this objective, the inventory was conducted on 16 plots of 25 hectares each, with 8 plots per site. Dendrometric parameters (diameter at breast height (DBH), total tree height) and tree growth and regeneration parameters, i.e., stem bark thickness of the unharvested and harvested portions of the trees (bark reconstitution) were measured. A total of 716 barked stems of Prunus africana in 2016 in 25 hectares constituted the study sample. Results show that sites do not influence diameter at breast height of P. africana trees (p > 0.05) or total tree height. The bark diameter of harvested trees and the bark diameter of unharvested trees varied significantly by site (p 0.05). In contrast, the annual growth rate of bark differed with altitude;the highest rate was observed in trees growing at high altitude (2.97 ± 0.9 mm/yr) compared to 2.23 ± 0.74 mm/yr at low altitude. In view of these results, this study indicates that a half-rotation of 7 years could allow an effective reconstitution of the bark of Prunus africana at the second passage on the remaining side of the same stem.
文摘Cassava bacterial blight (CBB) caused by Xanthomonas axonopodis pv. manihotis has been reported in several African countries since 1970. Knowledge of the virulence and diversity of Xanthomonas axonopodis pv. manihotis strains is important for an integrated control of CBB. The main objective of the present study was to characterize strains of Xanthomonas axonopodis collected from various regions in the DR-Congo. There was variability among strains for shape (form), contour (margin) and elevation. Bacterial cell size for the strains analyzed varied from 24.1 μm × 11.3 μm to 11.4 μm × 4.2 μm. All the Xanthomonas axonopodis pv. manihotis strains but one was motile. Two distinctive groups were identified based on radial growth of their colonies. The first group grows faster (7.8-10.5 mm/d) compared to the second group (4.8-6.9 mm/d). Five strains (Gandajika, Inera/Stat, Kansasa, Mulumba and Musakatshi) were classified as virulent with a damage rating ≤ 1 and four were aggressive (Luputa, M'vuazi, Boketa and Kiyaka) with a damage rating > 1. Significant differences were also observed among strains for disease onset, incidence and plant mortality. The highest incidence (33%) of bacterial blight 21 days after infestation (DAI) resulted from the Boketa strain inoculation and the lowest (0 % disease incidence) from INERA/STAT and Musakatshi strains. There was no clear association between geographic origin of the strains and their aggressiveness.
文摘Setting: Provincial General Reference Hospital of Bukavu, General Reference Hospital of Panzi, General Reference Hospital of Ciriri, General Reference Hospital of Nyatende and Biopharm Hospital Center. Objective: Contribute to the improvement of the anesthetic ECP of patients benefiting from MVA for incomplete abortion, Describe the methodology used for adoption of the dosage formula in Anesthesia for MVA, present the mathematical demonstration leading to the dosage formula in anesthesia for MVA. Materials and Methods: Our study was descriptive by mathematical demonstration of obtaining the equilibrium constant of the dosage formula of bipuvacaine 0.1% and Fentanyl 50 µg% adapted to the weight and specific size of patients treated anesthetically in MVA cases for incomplete abortion. We also carried out an operational research by first determining the interval where our equilibrium constant is included and secondly by means of the ends of the intervals found correlated to the ends of intervals of possible weights and sizes in the being normal human female of childbearing age to arrive at the real numerical value of the equilibrium constant of the BUKAVU Dosage Formula in the case of anesthesia for MVA during the management of incomplete abortions. Results: TWO-STAGE OPERATIONAL RESEARCH: • Determination of the interval where the equilibrium constant x = −0.95 x x by crossing the means between the extremes of volumes of anesthetic drugs giving a satisfactory sensory block without hemodynamic disturbance and the extremes of normal weight and height for women of childbearing age. We ended up with X = 0.37. Conclusion: At the end of our study which had the general objectives of contributing to the improvement of the anesthetic PEC of patients receiving MVA for incomplete abortion and specific objectives of describing the methodology used for adoption of the dosage formula in Anesthesia for MVA and present the mathematical demonstration which resulted in the dosage formula in nesthesia for MVA, it appears that the dosage formula of Bukavu, in case of intrathecal spinal analgesia of MVA for incomplete abortion provides precision on the specificity of the doses of bipuvacaine hypobarre 0.1% and Fentanyl 50 µg% reported to each patient according to her weight and height. Its application could therefore reduce morbidity and mortality and improve patient-practitioner comfort in the event of MVA for incomplete abortion following the dosage precision it provides.
文摘Pharmaceutical counterfeiting is a health scourge responsible for several cases of morbidity and mortality. Counterfeit medicines cause therapeutic failure, emergence of resistance in the treatment of infections. This study was conducted in order to identify counterfeit and authentic medicines in circulation in Lubumbashi. The study included artemether and artesunate for oral administration. A careful visual inspection of medicine, investigation of authenticity of pharmaceutical products from manufacturers and pharmaceutical regulatory authorities and determination of content were used as study parameters. 52 samples: 37 artemether and 15 of artésunate were collected. 7 samples (13%) have proven to be counterfeit. Artemether was the most counterfeit (71%) and 29% for artesunate. 6 (12%) samples were substandard according to the international pharmacopoeia in terms of content of active ingredient. Sixty-seven percent of non-compliance concerned counterfeit medicines. The proportion of non-compliance is highest among counterfeit medicines (71.43% vs 2.22%;p = 0.000004). It is obvious that strengthening the capacity of the drug regulatory authority of the DRC reduces the influx of counterfeit drug and substandard.
文摘Mutation breeding in crop plants is an effective approach in improvement of crop having narrow genetic base such as soybean. The main objective of the present study is to determine the effect of different doses of gamma irradiation on different morpho-agronomic characteristics. Agronomic traits that were analyzed included;grain yield, number of pods/plant, number of seeds/plant and weight of 100 seeds and numbers of days to 50% flowering. Morphometric characterization of the descriptive data included plant height, stem diameter, number of leaves/plant, leaflet length, leaflet width, number of ramifications/plant, and pod length and width at 3 lodge stage. The results of the present study revealed that the two gamma irradiation doses used (0.2 kGy and 0.4 kGy) decreased significantly most of agronomic and morphological traits evaluated in M1 populations. Different effects of 0.2 kGy and 0.4 kGy irradiation were observed in M2 populations with significant increase of grain yields and yield components in all the three soybean varieties. In general, a significant decrease or no changes of morphological traits were observed for the two irradiation doses in M2 populations. The levels of changes varied among varieties. Potential high yielding mutants were identified in progenies of irradiated seeds.
