Enterprises are facing problems such as the dynamic matching of talents and strategies,and the construction of organizational resilience.Based on this,this paper deeply explores the significance of the research on the...Enterprises are facing problems such as the dynamic matching of talents and strategies,and the construction of organizational resilience.Based on this,this paper deeply explores the significance of the research on the“Double Helix”model of strategic human resource management in the VUCA era and the practical construction of the“Double Helix”model:the implementation path of key dimensions,aiming to achieve the coordinated progress of the two through strategies such as improving talent density,forging organizational resilience,and promoting the coordinated integration mechanism of the Double Helix,so as to provide scientific human resource management strategies for enterprises,help enterprises enhance their competitiveness in a complex and changeable environment,and achieve sustainable development.展开更多
This paper presents the characteristics of a double helix capacitance sensor for measurement of the liquid holdup in horizontal oil–water two-phase flow. The finite element method is used to calculate the sensitivity...This paper presents the characteristics of a double helix capacitance sensor for measurement of the liquid holdup in horizontal oil–water two-phase flow. The finite element method is used to calculate the sensitivity field of the sensor in a pipe with 20 mm inner diameter and the effect of sensor geometry on the distribution of sensitivity field is presented. Then, a horizontal oil–water two-phase flow experiment is carried out to measure the response of the double helix capacitance sensor, in which a novel method is proposed to calibrate the liquid holdup based on three pairs of parallel-wire capacitance probes. The performance of the sensor is analyzed in terms of the flow structures detected by mini-conductance array probes.展开更多
Both racemate and enantiomer of a novel double helix,binaphthylcyclooctaterthiophene(BN-COTh),which is a DNA-like molecule constructed by two single helices intertwined with each other via covalent bonds,have been syn...Both racemate and enantiomer of a novel double helix,binaphthylcyclooctaterthiophene(BN-COTh),which is a DNA-like molecule constructed by two single helices intertwined with each other via covalent bonds,have been synthesized with two building blocks,cycloocta-tetrathiophene(COTh) and cyclooctadinaphthyldithiophene(CONT) fused together via Negishi coupling reaction.Another homologue,dinaphthylcyclooctaterthiophene(DN-COTh) has been employed together as a model compound.Besides the synthetic work,BN-COTh and DN-COTh have been investigated by studying their crystal structures,spectroscopic behaviors,chiral resolution and chiral characteristics,including circular dichroism(CD) spectra and optical rotations.In addition,the novel crystal of enantiomer of(R,R,R)-BN-COTh has been explored.The enantiomer molecules packing along b-axis to form a larger and extended assembly packing due to intermolecular interactions between the enantiomer molecules and chloroform molecules in crystal.展开更多
In order to solve the problem of using new nozzle is proposed in fire rescue robot. middle or low water pressure to form fine water mist, a Existing water mist nozzles are basically used for high pressure and in large...In order to solve the problem of using new nozzle is proposed in fire rescue robot. middle or low water pressure to form fine water mist, a Existing water mist nozzles are basically used for high pressure and in large size, complex structure and poor low pressure atomization effect in comparison with requirement of snake-like fire rescue robots. On the basis of comprehensive typical spray noz- zles, a direct spiral double helix converging nozzle （DSDHCN） is proposed, which has the advanta- ges of small volume, light weight, simple structure, and convenient installation. To make the spray nozzle have good performance, and meet the requirements of more efficient fire extinguishing, a nu- merical study is carried out to analyze the internal and external full flow field of nozzle. A gas-liquid two-phase flow is applied to simulate the external full flow field of nozzle with VOF model in fluent software. The simulation results show the real situation of water flow out of the atomization nozzle and the water jet trajectory. Some simulations about middle or low water pressure direct spiral double he- lix converging optimized nozzle have been done in 30bar pressure. The simulation results show that the optimized nozzle structure not only makes the spray droplets have a good cone angle, but also have a sufficient axial velocity,which proves the structure rationality of the proposed optimized nozzle.展开更多
We study the ferroelectricity in a one-dimensional(1D)system composed of a double helix SnIP with absorbing water molecules.Our ab initio calculations reveal two factors that are critical to the electrical polarizatio...We study the ferroelectricity in a one-dimensional(1D)system composed of a double helix SnIP with absorbing water molecules.Our ab initio calculations reveal two factors that are critical to the electrical polarization.The first one is the orientation of polarized water molecules staying in the R2 region of SnIP.The second one is the displacement of I atom which roots from subtle interaction with absorbed water molecules.A reasonable scenario of polarization flipping is proposed in this study.In the scenario,the water molecule is rolling-up with keeping the magnitude of its electrical dipole and changing its direction,meanwhile,the displacement of I atoms is also reversed.Highly tunable polarization can be achieved by applying strain,with 26.5%of polarization enhancement by applying tensile strain,with only 4%degradation is observed with 4%compressive strain.Finally,the direct band gap is also found to be correlated with strain.展开更多
This paper reports a double helix model of charge transfer in DNA molecule. The calculated results show that the transmission characteristics of DNA are not only related to the longitudinal transfer but also to the he...This paper reports a double helix model of charge transfer in DNA molecule. The calculated results show that the transmission characteristics of DNA are not only related to the longitudinal transfer but also to the helicity of molecule. It finds that there are four transmission bands centred at 0.92, 3.07, 7.75 and 8.87eV, also the width and intensity of bands corresponding to the helix direction are less than that of the longitudinal direction. With the increase of hopping energy, transmission bands become wide so that the transmission ability is enhanced.展开更多
For the detection environment of complex walls such as high-rise buildings,a double helix wall climbing robot(DHWCR)with strong adsorption force and good stability is designed and developed,which uses symmetrical prop...For the detection environment of complex walls such as high-rise buildings,a double helix wall climbing robot(DHWCR)with strong adsorption force and good stability is designed and developed,which uses symmetrical propellers to provide adsorption force.The symmetrical driving structure can provide smooth thrust for the DHWCR,so that the robot can be absorbed to the wall surface with different roughness.A left and right control frame with multiple degrees of freedom is designed,which can adjust the fixed position of the brushless propeller motor in the front and back directions,realize the continuous adjustable thrust direction of the robot,and improve the flexibility of the robot movement.Using the front wheel steering mechanism with universal joint,the steering control of the DHWCR is realized by differential control.In the vertical to ground transition,the front and rear brushless motors can provide the pull up and oblique thrust,so that the DHWCR can smoothly transition to the vertical wall.The motion performance and adaptability of the DHWCR in the horizontal ground and vertical wall environment are tested.The results show that the DHWCR can switch motion between the horizontal ground and vertical wall,and can stably adsorb on the vertical wall with flexible attitude control.The DHWCR can move at a fast speed.The speed on the horizontal ground is higher than that on the vertical wall,which verifies the feasibility and reliability of the DHWCR moving stably on the vertical wall.展开更多
Recent theoretical work has predicted the existence of a“dipole spiral”structure in strained freestanding membranes of PbTiO_(3),suggesting a potential route to enhanced electromechanical responses[Phys.Rev.Lett.133...Recent theoretical work has predicted the existence of a“dipole spiral”structure in strained freestanding membranes of PbTiO_(3),suggesting a potential route to enhanced electromechanical responses[Phys.Rev.Lett.133046802(2024)].However,its microscopic nature,energetic landscape,and electronic properties remain largely unexplored from a first-principles perspective.Here,using density functional theory on PbTiO3 under biaxial tensile strain,we identify a novel form of polar order:a chiral,non-collinear ferroelectric double helix.We find that two distinct,intertwined polarization helices are formed by the local Pb-O and Ti-O dipoles,reminiscent of DNA.This topology is stabilized by a collective helical twisting of the encompassing oxygen cages(the polyhedra for both Pb and Ti cations),which gives rise to an electric Dzyaloshinskii–Moriya-like interaction.The resulting structure,which can be conceptualized as a“self-moiré”crystal,exhibits two coupled functionalities.First,it possesses a rotational pseudo-zero-energy mode that underpins a giant piezoelectric response(e_(33)≈16C/m^(2)).Second,the long-period potential reconstructs the electronic band structure,leading to a multi-valley electronic topology at the valence band edge.Our work establishes a physical route to designing complex chiral order that supports both giant electromechanical coupling and multi-valley electronics.展开更多
Traditional Chinese Medicine (TCM) education increasingly faces epistemic dependence underadditive curricula that translate TCM concepts through biomedical standards, producing cognitive compartmentalization and weake...Traditional Chinese Medicine (TCM) education increasingly faces epistemic dependence underadditive curricula that translate TCM concepts through biomedical standards, producing cognitive compartmentalization and weakening theoretical autonomy. This conceptual paper proposesa Double Helix Model for structured co-existence between two epistemic strands: an A-strandgrounded in classical canons and xiang-based pattern thinking, and a B-strand providing scientificand technological instrumentation (systems biology, data science, and AI). Instead of premature fusion, the model stabilizes interaction through explicitly designed“base-pair”mechanisms, includingdigital hermeneutics for classical interpretation, knowledge graphs for structuring tacit knowledge,and dual-track clinical reasoning for comparative diagnosis. A staged five-year roadmap is outlinedto operationalize immersion, translation, and autonomous synthesis in curriculum design.展开更多
Hierarchical self-assembly is a fundamental principle in nature, which gives rise to astonishing supramolecular architectures that are an inspiration for the development of innovative materials in nanotechnolog）a Her...Hierarchical self-assembly is a fundamental principle in nature, which gives rise to astonishing supramolecular architectures that are an inspiration for the development of innovative materials in nanotechnolog）a Here, we present the unique structure of a cone-shaped amphiphilic designer peptide. While tracking its concentration-dependent morphologies, we observed elongated bilayered single tapes at the beginning of the assembly process, which further developed into novel double-helix-like superstructures at high concentrations. This architecture is characterized by a tight intertwisting of two individual helices, resulting in a periodic pitch size over their total lengths of several hundred nanometers. Solution X-ray scattering data revealed a marked 2-layered internal organization. All these characteristics remained unaltered for the investigated period of almost three months. In their collective morphology, the assemblies are integrated into a network with hydrogel characteristics. Such a peptide-based structure holds promise as a building block for next-generation nanostructured biomaterials.展开更多
The unzipping process of double-stranded DNA is analysed using a discrete model at the base level [Chin. Phys. Lett. 22 （2005）1540]. The numerical results are consistent with the experimental observations on the for...The unzipping process of double-stranded DNA is analysed using a discrete model at the base level [Chin. Phys. Lett. 22 （2005）1540]. The numerical results are consistent with the experimental observations on the force-displacement behaviour including the sequence-dependence. We find that the hydrogen bond interaction in a base pair is crucially important to the force-displacement profile.展开更多
Flexible inorganic double helical semiconductors similar to DNA have fueled the demand for efficient materials with innovative structures and excellent properties.The recent discovery of tin phosphide iodide(SnIP),the...Flexible inorganic double helical semiconductors similar to DNA have fueled the demand for efficient materials with innovative structures and excellent properties.The recent discovery of tin phosphide iodide(SnIP),the first carbon-free double helical semiconductor at an atomic level,has opened new avenues of research for semiconducting devices such as thermoelectric and sensor devices,solar cells,and photocatalysis.It has drawn significant academic attention due to its high structural flexibility,band gap in the visible spectrum range,and non-toxic elements.Herein,the recent progress in developing SnIP,including its prestigious structure,versatile and intriguing properties,and synthesis,is summarized.Other analogues of SnIP and SnIP-based hybrid materials and their applications in photocatalysis are also discussed.Finally,the review concludes with a critical summary and future aspects of this new inorganic semiconductor.展开更多
The development of synthetic polymers that mimic the double-stranded helical structure of DNA is a fascinating topic in polymer science.In this study,we designed and synthesized two chiral norbornene monomers containi...The development of synthetic polymers that mimic the double-stranded helical structure of DNA is a fascinating topic in polymer science.In this study,we designed and synthesized two chiral norbornene monomers containing adenine and thymine,which were mixed to form a hydrogen-bonding complementary complex,by which a ring-opening metathesis polymerization(ROMP)was performed.High-resolution transmission electron microscopy(HRTEM)undoubtedly showed the self-assembly of the optically active complementary nucleobasefunctionalized polynorbornenes into a double helix.Computer simulations and a two-dimensional nuclear Overhauser effect spectroscopy(2DNOESY)experiment showed that the doublestranded helical polynorbornene was derived from a copolymer of alternating adenine and thymine units.展开更多
High resolution structural studies of DNA and DNA binding proteins by atomic force microscopy(AFM) require well-bound samples on suitably flat substrates. Adsorbing the DNA onto a positively charged supported lipid bi...High resolution structural studies of DNA and DNA binding proteins by atomic force microscopy(AFM) require well-bound samples on suitably flat substrates. Adsorbing the DNA onto a positively charged supported lipid bilayer has previously been shown to be a potentially effective strategy for structural studies with AFM. Here, using our home-built frequency-modulation AFM(FM-AFM), we show that these bilayer substrates are only maximally effective for high resolution AFM when the samples are short, linear DNA, compared with circular plasmid DNA. We find that, with the former sample, the measured width of the DNA is about 2 nm, the known DNA diameter, and there is a clear height modulation along the length of the DNA with a periodicity of about 3.4 nm, in excellent agreement with the known pitch of the double helix. This sample preparation strategy is expected to enable higher resolution studies of DNA and DNA binding proteins with FM-AFM than that can presently be achieved.展开更多
As a core compulsory course for English majors majoring in teacher education,Literary Theory and Criticism plays an important role in enhancing text understanding,cultivating critical thinking,and shaping correct valu...As a core compulsory course for English majors majoring in teacher education,Literary Theory and Criticism plays an important role in enhancing text understanding,cultivating critical thinking,and shaping correct values in the future development of students.Influenced by traditional teaching ideas,students have many difficulties when learning this course,such as insufficient theoretical understanding,inadequate ability improvement,and not enough investment in course learning.In response to the above issues,this course focuses closely on the fundamental task of“cultivating virtue and nurturing people”,relying on modern information technology and introducing research methods of digital humanities.This course uses“7C”teaching mode under the“three-level integration”,in which“teaching”and“education”are carried out synchronously,and“teacher”and“student”are developed together,in order to greatly enhance students’learning participation and course satisfaction.展开更多
Highly sensitive gas detection plays a crucial role in advanced scientific and technological fields.This paper presents a parts-per-quadrillion(ppq)level ultra-highly sensitive light-induced thermoelectric spectroscop...Highly sensitive gas detection plays a crucial role in advanced scientific and technological fields.This paper presents a parts-per-quadrillion(ppq)level ultra-highly sensitive light-induced thermoelectric spectroscopy(LITES)sensor for the first time.The artificial fish swarm algorithm auto-designed multi-pass cell(MPC)with double helix pattern,and the polymer modified round-head quartz tuning fork(QTF)with low-resonant frequency(f0)were adopted to improve the gas absorption and QTF's detection ability.The obtained MPC,with a long optical path length(OPL)of 25.8 m and a small volume of 165.8 ml,is beneficial for increasing gas absorption while keeping the sensor compact.The novel QTF was structurally optimized to obtain low f0(~9.5 kHz)and modified by polydimethylsiloxane(PDMS)to reduce heat diffusion and enhance vibration amplitude.A strong absorption line of carbon monoxide(CO)located in the mid-infrared region(4.59 pm)was chosen as the target line.The signal-to-noise ratio(SNR)of CO-LITES sensor based on the novel QTF was improved by 10.59 times,reaching the highest level when compared to the commercial QTF.The corresponding minimum detection limit(MDL)was calculated to be 23 ppt.When the integration time of the sensor system was increased to 500 s,the MDL could be improved to 920.7 ppq.Compared to the reported spectroscopy techniques for CO gas detection,the LITES sensor in this study offfers an excellent result in terms of detection sensitivity.展开更多
基金Horizontal Topic of Suzhou Institute of Industrial Technology:Design and Optimization of Digital Salary System for Intelligent Technology Enterprises(Project No.:SIITHT2024006078)。
文摘Enterprises are facing problems such as the dynamic matching of talents and strategies,and the construction of organizational resilience.Based on this,this paper deeply explores the significance of the research on the“Double Helix”model of strategic human resource management in the VUCA era and the practical construction of the“Double Helix”model:the implementation path of key dimensions,aiming to achieve the coordinated progress of the two through strategies such as improving talent density,forging organizational resilience,and promoting the coordinated integration mechanism of the Double Helix,so as to provide scientific human resource management strategies for enterprises,help enterprises enhance their competitiveness in a complex and changeable environment,and achieve sustainable development.
基金Supported by the National Natural Science Foundation of China(50974095,41174109,61104148)the National Science and Technology Major Projects(2011ZX05020-006)
文摘This paper presents the characteristics of a double helix capacitance sensor for measurement of the liquid holdup in horizontal oil–water two-phase flow. The finite element method is used to calculate the sensitivity field of the sensor in a pipe with 20 mm inner diameter and the effect of sensor geometry on the distribution of sensitivity field is presented. Then, a horizontal oil–water two-phase flow experiment is carried out to measure the response of the double helix capacitance sensor, in which a novel method is proposed to calibrate the liquid holdup based on three pairs of parallel-wire capacitance probes. The performance of the sensor is analyzed in terms of the flow structures detected by mini-conductance array probes.
基金supported by the National Natural Science Foundation of China(Nos.21672053 and 21672054)Innovation Scientists and Technicians Troop Construction Projects of Henan Province(C20150011)。
文摘Both racemate and enantiomer of a novel double helix,binaphthylcyclooctaterthiophene(BN-COTh),which is a DNA-like molecule constructed by two single helices intertwined with each other via covalent bonds,have been synthesized with two building blocks,cycloocta-tetrathiophene(COTh) and cyclooctadinaphthyldithiophene(CONT) fused together via Negishi coupling reaction.Another homologue,dinaphthylcyclooctaterthiophene(DN-COTh) has been employed together as a model compound.Besides the synthetic work,BN-COTh and DN-COTh have been investigated by studying their crystal structures,spectroscopic behaviors,chiral resolution and chiral characteristics,including circular dichroism(CD) spectra and optical rotations.In addition,the novel crystal of enantiomer of(R,R,R)-BN-COTh has been explored.The enantiomer molecules packing along b-axis to form a larger and extended assembly packing due to intermolecular interactions between the enantiomer molecules and chloroform molecules in crystal.
基金Supported by the National Natural Science Foundation of China(No.61105086)Self-Planned Task(SKLRS-2010-MS-12)of State Key Laboratory of Robotics and System(HIT)Hubei Province Natural Science Foundation(No.2010CDB03405)
文摘In order to solve the problem of using new nozzle is proposed in fire rescue robot. middle or low water pressure to form fine water mist, a Existing water mist nozzles are basically used for high pressure and in large size, complex structure and poor low pressure atomization effect in comparison with requirement of snake-like fire rescue robots. On the basis of comprehensive typical spray noz- zles, a direct spiral double helix converging nozzle （DSDHCN） is proposed, which has the advanta- ges of small volume, light weight, simple structure, and convenient installation. To make the spray nozzle have good performance, and meet the requirements of more efficient fire extinguishing, a nu- merical study is carried out to analyze the internal and external full flow field of nozzle. A gas-liquid two-phase flow is applied to simulate the external full flow field of nozzle with VOF model in fluent software. The simulation results show the real situation of water flow out of the atomization nozzle and the water jet trajectory. Some simulations about middle or low water pressure direct spiral double he- lix converging optimized nozzle have been done in 30bar pressure. The simulation results show that the optimized nozzle structure not only makes the spray droplets have a good cone angle, but also have a sufficient axial velocity,which proves the structure rationality of the proposed optimized nozzle.
基金the Natural Science Foundation of Jiangsu Province,China(Grant No.BK20210198)the National Natural Science Foundation of China(Grant No.12204095)+1 种基金the Fundamental Research Funds for the Central Universities(Grant No.2242022R10197)the National Natural Science Foundation of China(Grant No.11834002).
文摘We study the ferroelectricity in a one-dimensional(1D)system composed of a double helix SnIP with absorbing water molecules.Our ab initio calculations reveal two factors that are critical to the electrical polarization.The first one is the orientation of polarized water molecules staying in the R2 region of SnIP.The second one is the displacement of I atom which roots from subtle interaction with absorbed water molecules.A reasonable scenario of polarization flipping is proposed in this study.In the scenario,the water molecule is rolling-up with keeping the magnitude of its electrical dipole and changing its direction,meanwhile,the displacement of I atoms is also reversed.Highly tunable polarization can be achieved by applying strain,with 26.5%of polarization enhancement by applying tensile strain,with only 4%degradation is observed with 4%compressive strain.Finally,the direct band gap is also found to be correlated with strain.
基金Project supported by the National Natural Science Foundation of China （Grant No 60571062） and the Natural Science Foundation of Shandong Province, China （Grant No Y2004G09）.
文摘This paper reports a double helix model of charge transfer in DNA molecule. The calculated results show that the transmission characteristics of DNA are not only related to the longitudinal transfer but also to the helicity of molecule. It finds that there are four transmission bands centred at 0.92, 3.07, 7.75 and 8.87eV, also the width and intensity of bands corresponding to the helix direction are less than that of the longitudinal direction. With the increase of hopping energy, transmission bands become wide so that the transmission ability is enhanced.
基金supported by the Key Research Development and Promotion Special Project of Henan Province,under Grant 212102310119 and 212102210358Scientific Research Foundation for High-level Talents of Henan Institute of Technology,under Grant KQ1869+7 种基金2021 Provincial Higher Education Teaching Reform General Project"Research and Practice of Grassroots Teaching Management Construction in Local Application-oriented Universities under the Background of Professional Certification",under Grant SJGY20210520University-Industry Collaborative Education Program,under Grant 202101187010 and 202102120046Innovation and Entrepreneurship Training Program for College Students of Henan Province,under Grant 202211329011Educational and Teaching Reform Research and Practice Project of Henan Institute of Technology,under Grant 2021-YB023 and JJXY-2021005Innovative Education Curriculum Construction Project of Henan Institute of Technology,under Grant CX-2021-0052022 Xinxiang Federation of Social Sciences Research topic,under Grant SKL-2022-254 and SKL-2022-2282022 Annual Research Topic of Henan Federation of Social Sciences,under Grant SKL-2022-26922022 Annual Research Project of Henan Federation of Social Sciences:"Research on Rural Revitalization Strategy of Financial Service Model Innovation in Henan Province",under Grant SKL-2022-2692.
文摘For the detection environment of complex walls such as high-rise buildings,a double helix wall climbing robot(DHWCR)with strong adsorption force and good stability is designed and developed,which uses symmetrical propellers to provide adsorption force.The symmetrical driving structure can provide smooth thrust for the DHWCR,so that the robot can be absorbed to the wall surface with different roughness.A left and right control frame with multiple degrees of freedom is designed,which can adjust the fixed position of the brushless propeller motor in the front and back directions,realize the continuous adjustable thrust direction of the robot,and improve the flexibility of the robot movement.Using the front wheel steering mechanism with universal joint,the steering control of the DHWCR is realized by differential control.In the vertical to ground transition,the front and rear brushless motors can provide the pull up and oblique thrust,so that the DHWCR can smoothly transition to the vertical wall.The motion performance and adaptability of the DHWCR in the horizontal ground and vertical wall environment are tested.The results show that the DHWCR can switch motion between the horizontal ground and vertical wall,and can stably adsorb on the vertical wall with flexible attitude control.The DHWCR can move at a fast speed.The speed on the horizontal ground is higher than that on the vertical wall,which verifies the feasibility and reliability of the DHWCR moving stably on the vertical wall.
基金supported by Zhejiang Provincial Natural Science Foundation of China(Grant No.LR25A040004)。
文摘Recent theoretical work has predicted the existence of a“dipole spiral”structure in strained freestanding membranes of PbTiO_(3),suggesting a potential route to enhanced electromechanical responses[Phys.Rev.Lett.133046802(2024)].However,its microscopic nature,energetic landscape,and electronic properties remain largely unexplored from a first-principles perspective.Here,using density functional theory on PbTiO3 under biaxial tensile strain,we identify a novel form of polar order:a chiral,non-collinear ferroelectric double helix.We find that two distinct,intertwined polarization helices are formed by the local Pb-O and Ti-O dipoles,reminiscent of DNA.This topology is stabilized by a collective helical twisting of the encompassing oxygen cages(the polyhedra for both Pb and Ti cations),which gives rise to an electric Dzyaloshinskii–Moriya-like interaction.The resulting structure,which can be conceptualized as a“self-moiré”crystal,exhibits two coupled functionalities.First,it possesses a rotational pseudo-zero-energy mode that underpins a giant piezoelectric response(e_(33)≈16C/m^(2)).Second,the long-period potential reconstructs the electronic band structure,leading to a multi-valley electronic topology at the valence band edge.Our work establishes a physical route to designing complex chiral order that supports both giant electromechanical coupling and multi-valley electronics.
文摘Traditional Chinese Medicine (TCM) education increasingly faces epistemic dependence underadditive curricula that translate TCM concepts through biomedical standards, producing cognitive compartmentalization and weakening theoretical autonomy. This conceptual paper proposesa Double Helix Model for structured co-existence between two epistemic strands: an A-strandgrounded in classical canons and xiang-based pattern thinking, and a B-strand providing scientificand technological instrumentation (systems biology, data science, and AI). Instead of premature fusion, the model stabilizes interaction through explicitly designed“base-pair”mechanisms, includingdigital hermeneutics for classical interpretation, knowledge graphs for structuring tacit knowledge,and dual-track clinical reasoning for comparative diagnosis. A staged five-year roadmap is outlinedto operationalize immersion, translation, and autonomous synthesis in curriculum design.
文摘Hierarchical self-assembly is a fundamental principle in nature, which gives rise to astonishing supramolecular architectures that are an inspiration for the development of innovative materials in nanotechnolog）a Here, we present the unique structure of a cone-shaped amphiphilic designer peptide. While tracking its concentration-dependent morphologies, we observed elongated bilayered single tapes at the beginning of the assembly process, which further developed into novel double-helix-like superstructures at high concentrations. This architecture is characterized by a tight intertwisting of two individual helices, resulting in a periodic pitch size over their total lengths of several hundred nanometers. Solution X-ray scattering data revealed a marked 2-layered internal organization. All these characteristics remained unaltered for the investigated period of almost three months. In their collective morphology, the assemblies are integrated into a network with hydrogel characteristics. Such a peptide-based structure holds promise as a building block for next-generation nanostructured biomaterials.
基金Supported by the National Natural Science Foundation of China under Grant No 10474109, the 100 Persons Project of Chinese Academy of sciences, the Foundation of Ministry of Personnel of China, and Shanghai Supercomputer Center of China.
文摘The unzipping process of double-stranded DNA is analysed using a discrete model at the base level [Chin. Phys. Lett. 22 （2005）1540]. The numerical results are consistent with the experimental observations on the force-displacement behaviour including the sequence-dependence. We find that the hydrogen bond interaction in a base pair is crucially important to the force-displacement profile.
基金supported by the National Natural Science Foundation of China(No.52072198).
文摘Flexible inorganic double helical semiconductors similar to DNA have fueled the demand for efficient materials with innovative structures and excellent properties.The recent discovery of tin phosphide iodide(SnIP),the first carbon-free double helical semiconductor at an atomic level,has opened new avenues of research for semiconducting devices such as thermoelectric and sensor devices,solar cells,and photocatalysis.It has drawn significant academic attention due to its high structural flexibility,band gap in the visible spectrum range,and non-toxic elements.Herein,the recent progress in developing SnIP,including its prestigious structure,versatile and intriguing properties,and synthesis,is summarized.Other analogues of SnIP and SnIP-based hybrid materials and their applications in photocatalysis are also discussed.Finally,the review concludes with a critical summary and future aspects of this new inorganic semiconductor.
基金The authors thank the National Natural Science Foundation of China(grant no.21971037)the Jiangsu Provincial Natural Science Foundation of China(grant no.BK20170024)for the support of this research project.
文摘The development of synthetic polymers that mimic the double-stranded helical structure of DNA is a fascinating topic in polymer science.In this study,we designed and synthesized two chiral norbornene monomers containing adenine and thymine,which were mixed to form a hydrogen-bonding complementary complex,by which a ring-opening metathesis polymerization(ROMP)was performed.High-resolution transmission electron microscopy(HRTEM)undoubtedly showed the self-assembly of the optically active complementary nucleobasefunctionalized polynorbornenes into a double helix.Computer simulations and a two-dimensional nuclear Overhauser effect spectroscopy(2DNOESY)experiment showed that the doublestranded helical polynorbornene was derived from a copolymer of alternating adenine and thymine units.
基金the National Basic Research Program(973) of China(No.2013CB932801)the National Natural Science Foundation of China(Nos.991129000,11374207,11375253,31370750,21273148 and 11074168)the Fund of Chinese Academy of Sciences(No.KJCX2-EW-N03)
文摘High resolution structural studies of DNA and DNA binding proteins by atomic force microscopy(AFM) require well-bound samples on suitably flat substrates. Adsorbing the DNA onto a positively charged supported lipid bilayer has previously been shown to be a potentially effective strategy for structural studies with AFM. Here, using our home-built frequency-modulation AFM(FM-AFM), we show that these bilayer substrates are only maximally effective for high resolution AFM when the samples are short, linear DNA, compared with circular plasmid DNA. We find that, with the former sample, the measured width of the DNA is about 2 nm, the known DNA diameter, and there is a clear height modulation along the length of the DNA with a periodicity of about 3.4 nm, in excellent agreement with the known pitch of the double helix. This sample preparation strategy is expected to enable higher resolution studies of DNA and DNA binding proteins with FM-AFM than that can presently be achieved.
基金supported by Henan Province Teaching Reform and Practice Project(Project Fund No.135)—Research on the Reform of Literary Theory Courses for English Majors in Universities.
文摘As a core compulsory course for English majors majoring in teacher education,Literary Theory and Criticism plays an important role in enhancing text understanding,cultivating critical thinking,and shaping correct values in the future development of students.Influenced by traditional teaching ideas,students have many difficulties when learning this course,such as insufficient theoretical understanding,inadequate ability improvement,and not enough investment in course learning.In response to the above issues,this course focuses closely on the fundamental task of“cultivating virtue and nurturing people”,relying on modern information technology and introducing research methods of digital humanities.This course uses“7C”teaching mode under the“three-level integration”,in which“teaching”and“education”are carried out synchronously,and“teacher”and“student”are developed together,in order to greatly enhance students’learning participation and course satisfaction.
基金supports from the National Natural Science Foundation of China(Grant no.62335006,62022032,62275065,and 62405078)Key Laboratory of Opto-Electronic Information Acquisition and Manipulation(Anhui University),Ministry of Education(Grant no.OEIAM202202)+1 种基金Fundamental Research Funds for the Central Universities(Grant no.HIT.OCEF.2023011)Heilongjiang Postdoctoral Fund(Grant no.LBHZ23144).
文摘Highly sensitive gas detection plays a crucial role in advanced scientific and technological fields.This paper presents a parts-per-quadrillion(ppq)level ultra-highly sensitive light-induced thermoelectric spectroscopy(LITES)sensor for the first time.The artificial fish swarm algorithm auto-designed multi-pass cell(MPC)with double helix pattern,and the polymer modified round-head quartz tuning fork(QTF)with low-resonant frequency(f0)were adopted to improve the gas absorption and QTF's detection ability.The obtained MPC,with a long optical path length(OPL)of 25.8 m and a small volume of 165.8 ml,is beneficial for increasing gas absorption while keeping the sensor compact.The novel QTF was structurally optimized to obtain low f0(~9.5 kHz)and modified by polydimethylsiloxane(PDMS)to reduce heat diffusion and enhance vibration amplitude.A strong absorption line of carbon monoxide(CO)located in the mid-infrared region(4.59 pm)was chosen as the target line.The signal-to-noise ratio(SNR)of CO-LITES sensor based on the novel QTF was improved by 10.59 times,reaching the highest level when compared to the commercial QTF.The corresponding minimum detection limit(MDL)was calculated to be 23 ppt.When the integration time of the sensor system was increased to 500 s,the MDL could be improved to 920.7 ppq.Compared to the reported spectroscopy techniques for CO gas detection,the LITES sensor in this study offfers an excellent result in terms of detection sensitivity.
