DME设备大量应用于航路导航和进近着陆,其工作原理为通过测量机载设备与地面设备之间询问应答脉冲的传播时间而测出飞机到地面台的距离。Selex公司制造的1119A型DME设备为地面设备,相较于传统DME设备,其硬件集成度和数字化程度更高,维...DME设备大量应用于航路导航和进近着陆,其工作原理为通过测量机载设备与地面设备之间询问应答脉冲的传播时间而测出飞机到地面台的距离。Selex公司制造的1119A型DME设备为地面设备,相较于传统DME设备,其硬件集成度和数字化程度更高,维护更复杂。本文深入分析了1119A型DME设备的完整性检测预警(Integrity Test Alert)故障处理流程,通过详细梳理和总结经验,旨在提升导航设备维护中的安全管理能力,提高维修人员对新型设备的故障处理能力,确保在设备出现故障时能够迅速、准确地发现问题并加以解决,进一步巩固和强化整个航空安全建设。展开更多
A biologic drug is a medication produced from or containing components of living organisms.Given the rigorous testing that originator biologics undergo to establish Food and Drug Administration(FDA)Biologics License A...A biologic drug is a medication produced from or containing components of living organisms.Given the rigorous testing that originator biologics undergo to establish Food and Drug Administration(FDA)Biologics License Application(BLA)approval,their subsequent price yields a high burden on healthcare systems(1).Biologics account for 37%of prescription drug spending,despite comprising only 2%of all prescribed medications(2).Biosimilar medicines are designed to have active properties that are“highly similar”to a previously licensed reference product,leading to increased chemistry,manufacturing,and controls(CMC).展开更多
Dear Editor,Diabetic macular edema(DME)is a major cause of visual loss in diabetic patients,which is mainly caused by disruption of the blood-retinal barrier and loss of pericytes and endothelial cells,resulting in th...Dear Editor,Diabetic macular edema(DME)is a major cause of visual loss in diabetic patients,which is mainly caused by disruption of the blood-retinal barrier and loss of pericytes and endothelial cells,resulting in the leakage of plasma and lipids[1].Nowadays,laser photocoagulation,intravitreal injections of anti-vascular endothelial growth factor(anti-VEGF)drugs and dexamethasone implant.展开更多
Exploiting high-performance electrolyte holds the key for realization practical application of rechargeable magnesium batteries(RMBs).Herein,a new non-nucleophilic mononuclear electrolyte was developed and its electro...Exploiting high-performance electrolyte holds the key for realization practical application of rechargeable magnesium batteries(RMBs).Herein,a new non-nucleophilic mononuclear electrolyte was developed and its electrochemical active species was identified as[Mg(DME)_(3)][GaCl_(4)]_(2) through single-crystal X-ray diffraction analysis.The as-synthesized Mg(GaCl_(4))_(2)-IL-DME electrolyte could achieve a high ionic conductivity(9.85 m S cm^(-1)),good anodic stability(2.9 V vs.Mg/Mg^(2+)),and highly reversible Mg plating/stripping.The remarkable electrochemical performance should be attributed to the in-situ formation of Mg^(2+)-conducting Ga_(5)Mg_(2)alloy layer at the Mg/electrolyte interface during electrochemical cycling,which not only efficiently protects the Mg anode from passivation,but also allows for rapid Mg-ion transport.Significantly,the Mg(GaCl_(4))_(2)-IL-DME electrolyte showed excellent compatibility with both conversion and intercalation cathodes.The Mg/S batteries with Mg(Ga Cl_(4))_(2)-IL-DME electrolyte and KB/S cathode showed a high specific capacity of 839 m Ah g^(-1)after 50 cycles at 0.1 C with the Coulombic efficiency of~100%.Moreover,the assembled Mg|Mo_6 S_8 batteries delivered a reversible discharge capacity of 85 m Ah g^(-1)after 120 cycles at 0.2 C.This work provides a universal electrolyte for the realization of high-performance and practical RMBs,especially Mg/S batteries.展开更多
N-Hydroxyapiosporamide(N-hydap),a marine product derived from a sponge-associated fungus,has shown promising inhibitory effects on small cell lung cancer(SCLC).However,there is limited understanding of its metabolic p...N-Hydroxyapiosporamide(N-hydap),a marine product derived from a sponge-associated fungus,has shown promising inhibitory effects on small cell lung cancer(SCLC).However,there is limited understanding of its metabolic pathways and characteristics.This study explored the in vitro metabolic profiles of N-hydap in human recombinant cytochrome P450s(CYPs)and UDP-glucuronosyltransferases(UGTs),as well as human/rat/mice microsomes,and also the pharmacokinetic properties by HPLC-MS/MS.Additionally,the cocktail probe method was used to investigate the potential to create drug-drug interactions(DDIs).N-Hydap was metabolically unstable in various microsomes after 1 h,with about 50%and 70%of it being eliminated by CYPs and UGTs,respectively.UGT1A3 was the main enzyme involved in glucuronidation(over 80%),making glucuronide the primary metabolite.Despite low bioavailability(0.024%),N-hydap exhibited a higher distribution in the lungs(26.26%),accounting for its efficacy against SCLC.Administering N-hydap to mice at normal doses via gavage did not result in significant toxicity.Furthermore,N-hydap was found to affect the catalytic activity of drug metabolic enzymes(DMEs),particularly increasing the activity of UGT1A3,suggesting potential for DDIs.Understanding the metabolic pathways and properties of N-hydap should improve our knowledge of its drug efficacy,toxicity,and potential for DDIs.展开更多
针对当前地面测距机(DME)导航台的作用范围一般为200 n miles左右[3],飞机在航行过程中往往需要经过多个DME导航台,而传统的机载DME设备只能工作在单频率下,这就需要飞行员手动切换对应地面台的频率,从而增加了飞行员工作量的问题。本...针对当前地面测距机(DME)导航台的作用范围一般为200 n miles左右[3],飞机在航行过程中往往需要经过多个DME导航台,而传统的机载DME设备只能工作在单频率下,这就需要飞行员手动切换对应地面台的频率,从而增加了飞行员工作量的问题。本文从实际工程应用出发,通过对机载DME设备工作过程进行分析,提出多台轮询技术,研究并实现直接扫描和自由扫描两种模式情况,该技术可提高航路定位的精准性,减少飞行员工作量。展开更多
为了应对全球气候变暖这一国际性难题,CO_2捕集、利用和封存(Carbon Capture,Utilization and Storage,CCUS)技术应运而生,而石油石化行业作为高碳化行业,将面临更大的挑战。调研了全球石油石化行业在CCUS技术领域研究取得的最新进展,...为了应对全球气候变暖这一国际性难题,CO_2捕集、利用和封存(Carbon Capture,Utilization and Storage,CCUS)技术应运而生,而石油石化行业作为高碳化行业,将面临更大的挑战。调研了全球石油石化行业在CCUS技术领域研究取得的最新进展,列举了我国开展的一系列相关技术研发和示范项目,进一步阐述了该行业所取得的技术成果。提出了一套针对石油石化行业CCUS的技术方案,利用燃气锅炉产生的烟气与天然气进行三重整反应,将产生的合成气用于回注或者合成二甲醚(DME,分离出的CO_2用于驱油),并对这两种利用方式进行了经济性比较。在此基础上,提出了一种环境风险评估方法——定性评估为主的风险矩阵法,制定了风险重要性等级二维矩阵表和风险重要性等级划分标准,并就中国石油石化行业在CCUS技术领域的未来发展提出了几点建议。展开更多
文摘DME设备大量应用于航路导航和进近着陆,其工作原理为通过测量机载设备与地面设备之间询问应答脉冲的传播时间而测出飞机到地面台的距离。Selex公司制造的1119A型DME设备为地面设备,相较于传统DME设备,其硬件集成度和数字化程度更高,维护更复杂。本文深入分析了1119A型DME设备的完整性检测预警(Integrity Test Alert)故障处理流程,通过详细梳理和总结经验,旨在提升导航设备维护中的安全管理能力,提高维修人员对新型设备的故障处理能力,确保在设备出现故障时能够迅速、准确地发现问题并加以解决,进一步巩固和强化整个航空安全建设。
文摘A biologic drug is a medication produced from or containing components of living organisms.Given the rigorous testing that originator biologics undergo to establish Food and Drug Administration(FDA)Biologics License Application(BLA)approval,their subsequent price yields a high burden on healthcare systems(1).Biologics account for 37%of prescription drug spending,despite comprising only 2%of all prescribed medications(2).Biosimilar medicines are designed to have active properties that are“highly similar”to a previously licensed reference product,leading to increased chemistry,manufacturing,and controls(CMC).
基金Supported by National Natural Science Foundation of China(No.82171062No.82301222)Zhejiang Provincial Natural Science Foundation of China(No.LY20H120002).
文摘Dear Editor,Diabetic macular edema(DME)is a major cause of visual loss in diabetic patients,which is mainly caused by disruption of the blood-retinal barrier and loss of pericytes and endothelial cells,resulting in the leakage of plasma and lipids[1].Nowadays,laser photocoagulation,intravitreal injections of anti-vascular endothelial growth factor(anti-VEGF)drugs and dexamethasone implant.
基金financially supported by National Natural Science Foundation of China(21773291,52303130,62205231,61904118,22002102)Natural Science Foundation of the Jiangsu Higher Education Institutions of China(19KJA210005)+1 种基金Postgraduate Research&Practice Innovation Program of Jiangsu Province(SJCX23_1710)Postgraduate Research&Practice Innovation Program of Suzhou University of Science and Technology(CLKYCX23_06)。
文摘Exploiting high-performance electrolyte holds the key for realization practical application of rechargeable magnesium batteries(RMBs).Herein,a new non-nucleophilic mononuclear electrolyte was developed and its electrochemical active species was identified as[Mg(DME)_(3)][GaCl_(4)]_(2) through single-crystal X-ray diffraction analysis.The as-synthesized Mg(GaCl_(4))_(2)-IL-DME electrolyte could achieve a high ionic conductivity(9.85 m S cm^(-1)),good anodic stability(2.9 V vs.Mg/Mg^(2+)),and highly reversible Mg plating/stripping.The remarkable electrochemical performance should be attributed to the in-situ formation of Mg^(2+)-conducting Ga_(5)Mg_(2)alloy layer at the Mg/electrolyte interface during electrochemical cycling,which not only efficiently protects the Mg anode from passivation,but also allows for rapid Mg-ion transport.Significantly,the Mg(GaCl_(4))_(2)-IL-DME electrolyte showed excellent compatibility with both conversion and intercalation cathodes.The Mg/S batteries with Mg(Ga Cl_(4))_(2)-IL-DME electrolyte and KB/S cathode showed a high specific capacity of 839 m Ah g^(-1)after 50 cycles at 0.1 C with the Coulombic efficiency of~100%.Moreover,the assembled Mg|Mo_6 S_8 batteries delivered a reversible discharge capacity of 85 m Ah g^(-1)after 120 cycles at 0.2 C.This work provides a universal electrolyte for the realization of high-performance and practical RMBs,especially Mg/S batteries.
基金supported by the National Natural Science Foundation of China(Nos.82274002,42376124)Marine Economy Development Project of Guangdong Province(GDNRC[2021]52)+1 种基金Hainan Provincial Natural Science Foundation of China(823CXTD393)Key-Area Research and Development Program of Guangdong Province(2023B1111050008)。
文摘N-Hydroxyapiosporamide(N-hydap),a marine product derived from a sponge-associated fungus,has shown promising inhibitory effects on small cell lung cancer(SCLC).However,there is limited understanding of its metabolic pathways and characteristics.This study explored the in vitro metabolic profiles of N-hydap in human recombinant cytochrome P450s(CYPs)and UDP-glucuronosyltransferases(UGTs),as well as human/rat/mice microsomes,and also the pharmacokinetic properties by HPLC-MS/MS.Additionally,the cocktail probe method was used to investigate the potential to create drug-drug interactions(DDIs).N-Hydap was metabolically unstable in various microsomes after 1 h,with about 50%and 70%of it being eliminated by CYPs and UGTs,respectively.UGT1A3 was the main enzyme involved in glucuronidation(over 80%),making glucuronide the primary metabolite.Despite low bioavailability(0.024%),N-hydap exhibited a higher distribution in the lungs(26.26%),accounting for its efficacy against SCLC.Administering N-hydap to mice at normal doses via gavage did not result in significant toxicity.Furthermore,N-hydap was found to affect the catalytic activity of drug metabolic enzymes(DMEs),particularly increasing the activity of UGT1A3,suggesting potential for DDIs.Understanding the metabolic pathways and properties of N-hydap should improve our knowledge of its drug efficacy,toxicity,and potential for DDIs.
文摘针对当前地面测距机(DME)导航台的作用范围一般为200 n miles左右[3],飞机在航行过程中往往需要经过多个DME导航台,而传统的机载DME设备只能工作在单频率下,这就需要飞行员手动切换对应地面台的频率,从而增加了飞行员工作量的问题。本文从实际工程应用出发,通过对机载DME设备工作过程进行分析,提出多台轮询技术,研究并实现直接扫描和自由扫描两种模式情况,该技术可提高航路定位的精准性,减少飞行员工作量。
文摘为了应对全球气候变暖这一国际性难题,CO_2捕集、利用和封存(Carbon Capture,Utilization and Storage,CCUS)技术应运而生,而石油石化行业作为高碳化行业,将面临更大的挑战。调研了全球石油石化行业在CCUS技术领域研究取得的最新进展,列举了我国开展的一系列相关技术研发和示范项目,进一步阐述了该行业所取得的技术成果。提出了一套针对石油石化行业CCUS的技术方案,利用燃气锅炉产生的烟气与天然气进行三重整反应,将产生的合成气用于回注或者合成二甲醚(DME,分离出的CO_2用于驱油),并对这两种利用方式进行了经济性比较。在此基础上,提出了一种环境风险评估方法——定性评估为主的风险矩阵法,制定了风险重要性等级二维矩阵表和风险重要性等级划分标准,并就中国石油石化行业在CCUS技术领域的未来发展提出了几点建议。
