Over the course of millions of years,nature has evolved to ensure survival and presents us with a myriad of functional surfaces and structures that can boast high efficiency,multifunctionality,and sustainability.What ...Over the course of millions of years,nature has evolved to ensure survival and presents us with a myriad of functional surfaces and structures that can boast high efficiency,multifunctionality,and sustainability.What makes these surfaces particularly practical and effective is the intricate micropatterning that enables selective interactions with microstructures.Most of these structures have been realized in the laboratory environment using numerous fabrication techniques by tailoring specific surface properties.Of the available manufacturing methods,additive manufacturing(AM)has created opportunities for fabricating these structures as the complex architectures of the naturally occurring microstructures far exceed the traditional ways.This paper presents a concise overview of the fundamentals of such patterned microstructured surfaces,their fabrication techniques,and diverse applications.A comprehensive evaluation of micro fabrication methods is conducted,delving into their respective strengths and limitations.Greater emphasis is placed on AM processes like inkjet printing and micro digital light projection printing due to the intrinsic advantages of these processes to additively fabricate high resolution structures with high fidelity and precision.The paper explores the various advancements in these processes in relation to their use in microfabrication and also presents the recent trends in applications like the fabrication of microlens arrays,microneedles,and tissue scaffolds.展开更多
The exploration and utilization of marine re-sources demand advanced operational tools.At present,deep-sea vehicles equipped with manipulators serve as the primary platforms for underwater exploration.However,the pres...The exploration and utilization of marine re-sources demand advanced operational tools.At present,deep-sea vehicles equipped with manipulators serve as the primary platforms for underwater exploration.However,the pressure sensors responsible for detecting the subtle gripping forces of these manipulators still face significant technical challenges,primarily due to the extreme hydrostatic pressure,corrosive seawater environment,and stringent mechanical strength re-quirements.A dual-curing,waterproof digital light processing(DLP)resin has been developed to achieve micron-scale printing accuracy,excellent seawater resistance,and mechan-ical properties comparable to those of thermoplastic resins.More importantly,the deep-sea pressure sensor(DSPS)fea-tures a unique printed lattice structure that allows seawater to penetrate and equilibrate the internal and external pressures,effectively mitigating the effects of deep-sea hydrostatic pres-sure.Experimental results demonstrate that the sensor ex-hibits a wide detection range and high sensitivity,with a measured sensitivity of 0.77 kPa^(−1) under 30 MPa hydrostatic pressure and a signal fluctuation below 1.48%.Furthermore,both the sensitivity and detection range of the sensor can be tuned by adjusting the lattice parameters,providing a robust foundation for the advancement of marine resource explora-tion.展开更多
Although natural polymers have been widely used in constructing bone scaffolds,it still remains challenging to fabricate natural polymer-derived bone scaffolds with biomimetic mechanical properties as well as outstand...Although natural polymers have been widely used in constructing bone scaffolds,it still remains challenging to fabricate natural polymer-derived bone scaffolds with biomimetic mechanical properties as well as outstanding osteogenic properties for large-size and weight-bearing bone defects regeneration.Herein,an“organic-inorganic assembly”strategy is developed to construct silk fibroin(SF)-based bone scaffolds with the aforementioned merits.After secondary structure reshuffling,the 3.3-fold increment ofβ-sheet structures in SF hydrogel resulted in a 100-fold improvement of mineral-assembly efficacy via influencing the ion adsorption process and providing templates for mineral growth.Notably,abundant minerals were deposited within the hydrogel and also on the surface,which indicated entire mineral-assembly,which ensured the biomimetic mechanical properties of the digital light processing 3D printed SF hydrogel scaffolds with haversian-mimicking structure.In vitro experiments proved that the assembly between the mineral and SF results in rapid adhesion and enhanced osteogenic differentiation of human bone marrow-derived mesenchymal stem cells.In vivo experiments further proved that the mineral-assembled SF hydrogel scaffold could significantly enhance integration and bone regeneration at the weight-bearing site within one month.This SF-based“organic-inorganic assembly”strategy sheds light on constructing cell-free,growth factor-free and natural polymer-derived bone scaffolds with biomimetic 3D structure,mechanical properties and excellent osteogenic properties.展开更多
基金The National Science Foundation(NSF)through Grants ECCS-2111056 and CMMI-1846863.
文摘Over the course of millions of years,nature has evolved to ensure survival and presents us with a myriad of functional surfaces and structures that can boast high efficiency,multifunctionality,and sustainability.What makes these surfaces particularly practical and effective is the intricate micropatterning that enables selective interactions with microstructures.Most of these structures have been realized in the laboratory environment using numerous fabrication techniques by tailoring specific surface properties.Of the available manufacturing methods,additive manufacturing(AM)has created opportunities for fabricating these structures as the complex architectures of the naturally occurring microstructures far exceed the traditional ways.This paper presents a concise overview of the fundamentals of such patterned microstructured surfaces,their fabrication techniques,and diverse applications.A comprehensive evaluation of micro fabrication methods is conducted,delving into their respective strengths and limitations.Greater emphasis is placed on AM processes like inkjet printing and micro digital light projection printing due to the intrinsic advantages of these processes to additively fabricate high resolution structures with high fidelity and precision.The paper explores the various advancements in these processes in relation to their use in microfabrication and also presents the recent trends in applications like the fabrication of microlens arrays,microneedles,and tissue scaffolds.
基金supported by the National Natural Science Foundation of China(U22A20248,U24A6001,52127803,U24A20228,U22A2075,62174165,52301256,52401257,52201236 and 62204246)the National Key R&D Program of China(2024YFB3814100,2023YFC3603500)+9 种基金the Chinese Academy of Sciences Youth Innovation Promotion Association(2018334)the International Partnership Program of Chinese Academy of Sciences(181GJHZ2024138GC)the Talent Plan of Shanghai Branch,Chinese Academy of Sciences(CASSHB-QNPD-2023022)the Project of Zhejiang Province(2022R52004)the Natural Science Foundation of Zhejiang Province(LMS25F040007)the Natural Science Foundation of Zhejiang Province(LQ23F040004,LQ23F010016)the Ningbo Technology Project(2022A-007-C)the Ningbo Natural Science Foundations(2022J288,2023J049,2024J068 and 2024J241)the Ningbo Key Research and Development Program(2023Z097,2024Z148,2024Z143,2024Z199 and 2024Z171)the Ningbo Science and Technology Bureau(2023J266)。
文摘The exploration and utilization of marine re-sources demand advanced operational tools.At present,deep-sea vehicles equipped with manipulators serve as the primary platforms for underwater exploration.However,the pressure sensors responsible for detecting the subtle gripping forces of these manipulators still face significant technical challenges,primarily due to the extreme hydrostatic pressure,corrosive seawater environment,and stringent mechanical strength re-quirements.A dual-curing,waterproof digital light processing(DLP)resin has been developed to achieve micron-scale printing accuracy,excellent seawater resistance,and mechan-ical properties comparable to those of thermoplastic resins.More importantly,the deep-sea pressure sensor(DSPS)fea-tures a unique printed lattice structure that allows seawater to penetrate and equilibrate the internal and external pressures,effectively mitigating the effects of deep-sea hydrostatic pres-sure.Experimental results demonstrate that the sensor ex-hibits a wide detection range and high sensitivity,with a measured sensitivity of 0.77 kPa^(−1) under 30 MPa hydrostatic pressure and a signal fluctuation below 1.48%.Furthermore,both the sensitivity and detection range of the sensor can be tuned by adjusting the lattice parameters,providing a robust foundation for the advancement of marine resource explora-tion.
基金supported by the National Key Research and Development Program of China(2023YFB3813000)the National Natural Science Foundation of China(T2121004,92268203,32371411).
文摘Although natural polymers have been widely used in constructing bone scaffolds,it still remains challenging to fabricate natural polymer-derived bone scaffolds with biomimetic mechanical properties as well as outstanding osteogenic properties for large-size and weight-bearing bone defects regeneration.Herein,an“organic-inorganic assembly”strategy is developed to construct silk fibroin(SF)-based bone scaffolds with the aforementioned merits.After secondary structure reshuffling,the 3.3-fold increment ofβ-sheet structures in SF hydrogel resulted in a 100-fold improvement of mineral-assembly efficacy via influencing the ion adsorption process and providing templates for mineral growth.Notably,abundant minerals were deposited within the hydrogel and also on the surface,which indicated entire mineral-assembly,which ensured the biomimetic mechanical properties of the digital light processing 3D printed SF hydrogel scaffolds with haversian-mimicking structure.In vitro experiments proved that the assembly between the mineral and SF results in rapid adhesion and enhanced osteogenic differentiation of human bone marrow-derived mesenchymal stem cells.In vivo experiments further proved that the mineral-assembled SF hydrogel scaffold could significantly enhance integration and bone regeneration at the weight-bearing site within one month.This SF-based“organic-inorganic assembly”strategy sheds light on constructing cell-free,growth factor-free and natural polymer-derived bone scaffolds with biomimetic 3D structure,mechanical properties and excellent osteogenic properties.
